pubmed-sentences-benchmark  

PubMed:7605990 JSONTXT 10 Projects

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Id Subject Object Predicate Lexical cue
S1 0-147 Sentence denotes Positive and negative regulation of granulocyte-macrophage colony-stimulating factor promoter activity by AML1-related transcription factor, PEBP2.
S2 148-374 Sentence denotes The granulocyte-macrophage colony-stimulating factor (GM-CSF) gene promoter contains a consensus sequence for the polyomavirus enhancer binding-protein 2 (PEBP2) transcription factor, which consists of alpha and beta subunits.
S3 375-453 Sentence denotes There are at least two genes, alpha A and alpha B, encoding the alpha subunit.
S4 454-573 Sentence denotes alpha B is the mouse homologue of human AML1 gene detected at the breakpoints of t(8;21) and t(3;21) myeloid leukemias.
S5 574-718 Sentence denotes We examined alpha A1 (an alpha A-gene product) and alpha B1 and alpha B2 (two alpha B-encoded isomers) for their effects on the GM-CSF promoter.
S6 719-821 Sentence denotes PEBP2 alpha A1, alpha B1, and alpha B2 proteins bound the PEBP2 site within the mouse GM-CSF promoter.
S7 822-1029 Sentence denotes PEBP2 alpha A1 and alpha B1 enhanced the expression of the GM-CSF promoter-driven reporter plasmid in unstimulated and 12-O-tetradecanoylphorbol 13-acetate/phytohemagglutinin-stimulated human Jurkat T cells.
S8 1030-1092 Sentence denotes In contrast, the promoter activity was suppressed by alpha B2.
S9 1093-1216 Sentence denotes Coexpression of alpha B1 and alpha B2 showed that the promoter activity could be determined by the alpha B1/alpha B2 ratio.
S10 1217-1331 Sentence denotes Jurkat cell extract contained PEBP2 site-binding protein(s) that cross-reacted with antimouse alpha A1 antibodies.
S11 1332-1451 Sentence denotes Northern blot analysis indicated the expression of human PEBP2 alpha A, alpha B (AML1), and beta genes in Jurkat cells.
S12 1452-1708 Sentence denotes Although further studies are required to determine the precise role of PEBP2 in the GM-CSF promoter activity, the present findings suggested the importance of the relative ratio of different PEBP2 isoforms in regulating the levels of the promoter activity.