pubmed-sentences-benchmark  

PubMed:7594489 JSONTXT 10 Projects

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Id Subject Object Predicate Lexical cue
S1 0-203 Sentence denotes Triggering of complement receptors CR1 (CD35) and CR3 (CD11b/CD18) induces nuclear translocation of NF-kappa B (p50/p65) in human monocytes and enhances viral replication in HIV-infected monocytic cells.
S2 204-297 Sentence denotes Monocyte/macrophages may harbor HIV in a nonproductive fashion for prolonged periods of time.
S3 298-416 Sentence denotes Viral gene expression may be reactivated by stimulation of the cells with LPS or cytokines such as TNF-alpha in vitro.
S4 417-630 Sentence denotes The effect of LPS and TNF-alpha is mediated by their ability to induce nuclear translocation of the DNA-binding heterodimer NF-kappa B (p50/p65), which binds to a specific sequence in the HIV-long terminal repeat.
S5 631-799 Sentence denotes The present study demonstrates that triggering of complement receptors CR1 (CD35) and CR3 (CD11b/CD18) enhances viral replication in HIV-infected human monocytic cells.
S6 800-1014 Sentence denotes Monocytic cell lines and normal peripheral blood monocytes were infected with HIV-1 in vitro and cultured in the presence or absence of F(ab')2 fragments of monoclonal anti-CR1 or anti-CR3 Abs or with C3 fragments.
S7 1015-1223 Sentence denotes Stimulation of CR1 or CR3 induces a two- to fourfold increase in the amount of cell-associated and released p24 Ag in cell cultures that was equivalent to that observed in control cultures triggered with LPS.
S8 1224-1349 Sentence denotes We further observed that stimulation of CR1 or CR3 induces the nuclear translocation of NF-kappa B p50/p65 in infected cells.
S9 1350-1510 Sentence denotes Translocation of NF-kappa B p50/p65 was also observed following stimulation of CR1 or CR3 of uninfected peripheral blood monocytes from HIV-seronegative donors.
S10 1511-1619 Sentence denotes The amount of protein translocated was similar to that observed when cells were stimulated with rhTNF-alpha.
S11 1620-1732 Sentence denotes TNF-alpha did not mediate the translocation of NF-kappa B p50/p65 induced by triggering of complement receptors.
S12 1733-2033 Sentence denotes Taken together, these observations suggest that HIV gene expression may be activated in infected monocytes through interaction of the cells with complement-opsonized particles and that enhanced viral replication is associated with C3 receptor-mediated nuclear translocation of the NF-kappa B complex.