| Id |
Subject |
Object |
Predicate |
Lexical cue |
| S1 |
0-127 |
Sentence |
denotes |
Vitamin E therapy of acute CCl4-induced hepatic injury in mice is associated with inhibition of nuclear factor kappa B binding. |
| S2 |
128-279 |
Sentence |
denotes |
Oxidative stress, with reactive oxygen intermediate formation, may represent a common mechanism by which liver injury is induced by diverse etiologies. |
| S3 |
280-440 |
Sentence |
denotes |
Oxidative stress enhances nuclear factor kappa B (NF-kappa B) activity, and NF-kappa B activity has been shown to enhance the expression of cytotoxic cytokines. |
| S4 |
441-572 |
Sentence |
denotes |
Acute hepatic injury caused by reactive oxygen intermediate production was induced by an intraperitoneal injection of CCl4 in mice. |
| S5 |
573-703 |
Sentence |
denotes |
This injury was significantly inhibited by intravenous pretreatment of the mice with a water-soluble emulsion of alpha-tocopherol. |
| S6 |
704-843 |
Sentence |
denotes |
Alpha-tocopherol treatment of the mice given the CCl4 also reduced the NF-kappa B binding to levels approaching those found in normal mice. |
| S7 |
844-1023 |
Sentence |
denotes |
In vitro treatment of a monocyte/macrophage cell line with CCl4 led to enhanced NF-kappa B binding and an increase in tumor necrosis factor-alpha (TNF-alpha) messenger RNA levels. |
| S8 |
1024-1190 |
Sentence |
denotes |
Liver specimens taken from patients with acute fulminant hepatitis had markedly increased NF-kappa B binding activity in comparison with the binding of normal livers. |
| S9 |
1191-1345 |
Sentence |
denotes |
These data demonstrate that abolishing acute hepatic injury with alpha-tocopherol, a free radical scavenger, also eliminated increased NF-kappa B binding. |
| S10 |
1346-1546 |
Sentence |
denotes |
It is tempting to speculate that enhanced NF-kappa B expression caused by free radical production/oxidative stress may modulate liver injury, perhaps through an effect on cytotoxic cytokine synthesis. |
