| Id |
Subject |
Object |
Predicate |
Lexical cue |
| S1 |
0-62 |
Sentence |
denotes |
HMG-I binds to GATA motifs: implications for an HPFH syndrome. |
| S2 |
63-152 |
Sentence |
denotes |
We have examined binding of the nuclear protein HMG-I to the human gamma-globin promoter. |
| S3 |
153-321 |
Sentence |
denotes |
We find that HMG-I binds preferentially to the more 3' of a pair of GATA motifs in the gamma-globin promoter; this paired motif is bound by the erythroid factor GATA-1. |
| S4 |
322-587 |
Sentence |
denotes |
A naturally occurring mutation (-175 T-C) in the area bound by HMG-I results in overexpression of gamma-globin in adult red blood cells (HPFH) and up-regulation of the gamma-globin promoter in in vitro expression assays; HMG-I does not bind to this mutant sequence. |
| S5 |
588-686 |
Sentence |
denotes |
A survey of GATA motifs from other globin cis-elements demonstrates HMG-I binding to most of them. |
| S6 |
687-858 |
Sentence |
denotes |
These findings implicate HMG-I in the HPFH phenotype; we speculate that it may participate in the formation of multiprotein complexes that regulate globin gene expression. |
