pubmed-sentences-benchmark  

PubMed:7518838 JSONTXT 10 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function

Id Subject Object Predicate Lexical cue
S1 0-102 Sentence denotes Alpha-tocopherol inhibits agonist-induced monocytic cell adhesion to cultured human endothelial cells.
S2 103-252 Sentence denotes Antioxidants have been proposed to be anti-atherosclerotic agents; however, the mechanisms underlying their beneficial effects are poorly understood.
S3 253-430 Sentence denotes We have examined the effect of alpha-tocopherol (alpha-tcp) on one cellular event in atherosclerotic plaque development, monocyte adhesion to stimulated endothelial cells (ECs).
S4 431-616 Sentence denotes Human umbilical vein ECs were pretreated with alpha-tcp before stimulation with known agonists of monocyte adhesion: IL-1 (10 ng/ml), LPS (10 ng/ml), thrombin (30 U/ml), or PMA (10 nM).
S5 617-755 Sentence denotes Agonist-induced monocytic cell adhesion, but not basal adhesion, was inhibited in a time- and concentration-dependent manner by alpha-tcp.
S6 756-820 Sentence denotes The IC50 of alpha-tcp on an IL-1-induced response was 45 microM.
S7 821-1073 Sentence denotes The inhibition correlated with a decrease in steady state levels of E-selectin mRNA and cell surface expression of E-selectin which is consistent with the ability of a monoclonal antibody to E-selectin to inhibit monocytic cell adhesion in this system.
S8 1074-1242 Sentence denotes Probucol (50 microM) and N-acetylcysteine (20 mM) also inhibited agonist-induced monocytic cell adhesion; whereas, several other antioxidants had no significant effect.
S9 1243-1392 Sentence denotes Protein kinase C (PKC) does not appear to play a role in the alpha-tcp effect since no suppression of phosphorylation of PKC substrates was observed.
S10 1393-1522 Sentence denotes Activation of the transcription factor NF-kappa B is reported to be necessary but not sufficient for E-selectin expression in EC.
S11 1523-1676 Sentence denotes Electrophoretic mobility shift assays failed to show an alpha-tcp-induced decrease in activation of this transcription factor after cytokine stimulation.
S12 1677-1862 Sentence denotes It has been hypothesized that alpha-tcp acts as an anti-atherosclerotic molecule by inhibiting generation of oxidized LDL--a putative triggering molecule in the atherosclerotic process.
S13 1863-1937 Sentence denotes Our results point to a novel alternative mechanism of action of alpha-tcp.