| Id |
Subject |
Object |
Predicate |
Lexical cue |
| S1 |
0-94 |
Sentence |
denotes |
Interleukin-7 can induce the activation of Jak 1, Jak 3 and STAT 5 proteins in murine T cells. |
| S2 |
95-302 |
Sentence |
denotes |
The activation of Janus protein tyrosine kinases (Jak) and STAT (signal transducer and activator of transcription) proteins has recently been linked to the signal transduction mechanism of several cytokines. |
| S3 |
303-501 |
Sentence |
denotes |
IL-7 was observed to induce a rapid and dose-dependent tyrosine phosphorylation of Jak 1 and Jak 3 and concomitantly, the tyrosine phosphorylation and DNA binding activity of multiple STAT proteins. |
| S4 |
502-628 |
Sentence |
denotes |
The STAT proteins utilized by IL-7 were identical to those induced by IL-2 and could be identified as various STAT 5 isoforms. |
| S5 |
629-858 |
Sentence |
denotes |
Moreover, the induction of both Jak 1 and 3, and STAT 5 activity strongly correlated with the growth-promoting effects of IL-7, suggesting that this signal transduction mechanism may play a key role in IL-7-induced proliferation. |
