pubmed-sentences-benchmark  

PubMed:2105946 JSONTXT 30 Projects

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Id Subject Object Predicate Lexical cue
S1 0-137 Sentence denotes Transcriptional and post-transcriptional regulation of c-jun expression during monocytic differentiation of human myeloid leukemic cells.
S2 138-370 Sentence denotes AP-1, the polypeptide product of c-jun, recognizes and binds to specific DNA sequences and stimulates transcription of genes responsive to certain growth factors and phorbol esters such as 12-O-tetradecanoylphorbol-13-acetate (TPA).
S3 371-492 Sentence denotes We studied the effects of TPA on the regulation of c-jun gene expression in HL-60 cells during monocytic differentiation.
S4 493-673 Sentence denotes Low levels of c-jun transcripts were detectable in untreated HL-60 leukemic cells, increased significantly by 6 h, and reached near maximal levels by 24 h of exposure to 32 nM TPA.
S5 674-781 Sentence denotes Similar kinetics of c-jun induction by TPA were observed in human U-937 and THP-1 monocytic leukemia cells.
S6 782-919 Sentence denotes Similar findings were obtained with bryostatin 1 (10 nM), another activator of protein kinase C and inducer of monocytic differentiation.
S7 920-1081 Sentence denotes Furthermore, 1,25-dihydroxyvitamin D3 (0.5 microM), a structurally distinct agent which also induces HL-60 monocytic differentiation, increased c-jun expression.
S8 1082-1200 Sentence denotes TPA treatment of HL-60 cells in the presence of cycloheximide was associated with superinduction of c-jun transcripts.
S9 1201-1356 Sentence denotes Run-on analysis demonstrated detectable levels of c-jun gene transcription in untreated HL-60 cells, and that exposure to TPA increases this rate 3.3-fold.
S10 1357-1464 Sentence denotes Treatment of HL-60 cells with both TPA and cycloheximide had no effect on the rates of c-jun transcription.
S11 1465-1568 Sentence denotes The half-life of c-jun RNA as determined by treating HL-60 cells with TPA and actinomycin D was 30 min.
S12 1569-1700 Sentence denotes In contrast, the half-life of c-jun RNA in TPA-treated HL-60 cells exposed to cycloheximide and actinomycin D was greater than 2 h.
S13 1701-1883 Sentence denotes These findings suggested that the increase in c-jun RNA observed during TPA-induced monocytic differentiation is mediated by both transcriptional and post-transcriptional mechanisms.