| Id |
Subject |
Object |
Predicate |
Lexical cue |
| S1 |
0-95 |
Sentence |
denotes |
The actions of cyclosporin A and FK506 suggest a novel step in the activation of T lymphocytes. |
| S2 |
96-256 |
Sentence |
denotes |
Cyclosporin A and FK506 are immunosuppressive compounds that have similar inhibitory effects on the expression of several lymphokines produced by T lymphocytes. |
| S3 |
257-443 |
Sentence |
denotes |
Despite their similar effects the drugs bind to two different cytosolic protein, cyclophilin and FKBP respectively, which raises the possibility that they have different modes of action. |
| S4 |
444-735 |
Sentence |
denotes |
Using constructs in which mRNA production controlled by a specific transcription factor could be readily measured we found that both cyclosporin A and FK506 completely inhibited transcription activated by NF-AT, NFIL2 A, NFIL2 B and partially inhibited transcription activated by NF kappa B. |
| S5 |
736-842 |
Sentence |
denotes |
Cyclosporin A and FK506 inhibited only transcriptional activation that was dependent on Ca2+ mobilization. |
| S6 |
843-1044 |
Sentence |
denotes |
However, cyclosporin A and FK506 did not inhibit Ca2+ mobilization dependent expression of c-fos mRNA indicating that only a subset of signalling pathways regulated by Ca2+ is sensitive to these drugs. |
| S7 |
1045-1330 |
Sentence |
denotes |
Furthermore, we did not observe any qualitative differences between the effect of cyclosporin A and FK506 on six different transcription factors which suggests that these drugs may interfere with the activity of a novel Ca2+ dependent step that regulates several transcription factors. |
