| Id |
Subject |
Object |
Predicate |
Lexical cue |
| S1 |
0-112 |
Sentence |
denotes |
PPARgamma activation induces the expression of the adipocyte fatty acid binding protein gene in human monocytes. |
| S2 |
113-346 |
Sentence |
denotes |
The peroxisome-proliferator activated receptor gamma (PPARgamma), a member of the nuclear receptor superfamily of ligand activated transcription factors, plays a key role in the anti-diabetic actions of the thiazolidinediones (TZDs). |
| S3 |
347-533 |
Sentence |
denotes |
PPARgamma induces the expression of many genes involved in lipid anabolism, including the adipocyte fatty acid binding protein (aP2), and is a key regulator of adipocyte differentiation. |
| S4 |
534-640 |
Sentence |
denotes |
PPARgamma is also expressed in hematopoietic cells and is up-regulated in activated monocytes/macrophages. |
| S5 |
641-795 |
Sentence |
denotes |
Activation of PPARgamma may play a role in the induction of differentiation of macrophages to foam cells that are associated with atherosclerotic lesions. |
| S6 |
796-978 |
Sentence |
denotes |
We report that both natural and synthetic PPARgamma agonists induce time- and dose-dependent increases in aP2 mRNA in both primary human monocytes and the monocytic cell line, THP-1. |
| S7 |
979-1136 |
Sentence |
denotes |
These data suggest that PPARgamma activation may play a role in monocyte differentiation and function analogous to its well-characterized role in adipocytes. |
