| Id |
Subject |
Object |
Predicate |
Lexical cue |
| S1 |
0-115 |
Sentence |
denotes |
CBP/p300 integrates Raf/Rac-signaling pathways in the transcriptional induction of NF-ATc during T cell activation. |
| S2 |
116-230 |
Sentence |
denotes |
NF-ATc, an inducibly expressed transcription factor, controls gene expression in T lymphocytes and cardiomyocytes. |
| S3 |
231-393 |
Sentence |
denotes |
We show here that the transcriptional co-activators CBP/p300 bind to and control the activity of the inducible N-terminal transactivation domain of NF-ATc, TAD-A. |
| S4 |
394-562 |
Sentence |
denotes |
Similar to the N terminal transactivation domain of c-Jun, TAD-A is inducibly phosphorylated, but this phosphorylation is dispensable for the interaction with CBP/p300. |
| S5 |
563-776 |
Sentence |
denotes |
Constitutive active versions of c-Raf and Rac synergistically enhance the CBP/p300-mediated increase of TAD-A activity, indicating the important role CBP/p300 plays in the integration of T cell activation signals. |
| S6 |
777-990 |
Sentence |
denotes |
Since a mutation of CBP abolishing HAT activity is almost as active as wild-type CBP in T cells, functions of CBP/p300 other than histone acetylation appear to control the NF-AT-dependent transcription in T cells. |
