PubMed:10358178 JSONTXT 8 Projects

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Id Subject Object Predicate Lexical cue
S1 0-101 Sentence denotes Multiple NF-ATc isoforms with individual transcriptional properties are synthesized in T lymphocytes.
S2 102-250 Sentence denotes The transcription factor NF-ATc that controls gene expression in T lymphocytes and embryonic cardiac cells is expressed in three prominent isoforms.
S3 251-434 Sentence denotes This is due to alternative splice/polyadenylation events that lead to the predominant synthesis of two long isoforms in naive T cells and a shorter NF-ATc isoform in effector T cells.
S4 435-618 Sentence denotes Whereas the previously described isoform NF-ATc/A contains a relatively short C terminus, the longer isoforms, B and C, span extra C-terminal peptides of 128 and 246 aa, respectively.
S5 619-837 Sentence denotes We show here that in addition to the strong N-terminal trans-activation domain, TAD-A, which is common to all three NF-ATc isoforms, NF-ATc/C contains a second trans-activation domain, TAD-B, in its C-terminal peptide.
S6 838-1061 Sentence denotes Various stimuli of T cells that induce the activity of TAD-A also enhance the activity of TAD-B, but, unlike TAD-A, TAD-B remains unphosphorylated by protein from 12-O-tetradecanoyl 12-phorbol 13-acetate-stimulated T cells.
S7 1062-1157 Sentence denotes The shorter C-terminal peptide of isoform NF-ATc/B exerts a suppressive transcriptional effect.
S8 1158-1315 Sentence denotes These properties of NF-ATc/B and -C might be of importance for gene regulation in naive T lymphocytes in which NF-ATc/B and -C are predominantly synthesized.