Id |
Subject |
Object |
Predicate |
Lexical cue |
S1 |
0-101 |
Sentence |
denotes |
Multiple NF-ATc isoforms with individual transcriptional properties are synthesized in T lymphocytes. |
S2 |
102-250 |
Sentence |
denotes |
The transcription factor NF-ATc that controls gene expression in T lymphocytes and embryonic cardiac cells is expressed in three prominent isoforms. |
S3 |
251-434 |
Sentence |
denotes |
This is due to alternative splice/polyadenylation events that lead to the predominant synthesis of two long isoforms in naive T cells and a shorter NF-ATc isoform in effector T cells. |
S4 |
435-618 |
Sentence |
denotes |
Whereas the previously described isoform NF-ATc/A contains a relatively short C terminus, the longer isoforms, B and C, span extra C-terminal peptides of 128 and 246 aa, respectively. |
S5 |
619-837 |
Sentence |
denotes |
We show here that in addition to the strong N-terminal trans-activation domain, TAD-A, which is common to all three NF-ATc isoforms, NF-ATc/C contains a second trans-activation domain, TAD-B, in its C-terminal peptide. |
S6 |
838-1061 |
Sentence |
denotes |
Various stimuli of T cells that induce the activity of TAD-A also enhance the activity of TAD-B, but, unlike TAD-A, TAD-B remains unphosphorylated by protein from 12-O-tetradecanoyl 12-phorbol 13-acetate-stimulated T cells. |
S7 |
1062-1157 |
Sentence |
denotes |
The shorter C-terminal peptide of isoform NF-ATc/B exerts a suppressive transcriptional effect. |
S8 |
1158-1315 |
Sentence |
denotes |
These properties of NF-ATc/B and -C might be of importance for gene regulation in naive T lymphocytes in which NF-ATc/B and -C are predominantly synthesized. |