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PubMed:10208461 JSONTXT 10 Projects

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Id Subject Object Predicate Lexical cue
S1 0-279 Sentence denotes Bcl-6 expression in reactive follicular hyperplasia, follicular lymphoma, and angioimmunoblastic T-cell lymphoma with hyperplastic germinal centers: heterogeneity of intrafollicular T-cells and their altered distribution in the pathogenesis of angioimmunoblastic T-cell lymphoma.
S2 280-397 Sentence denotes BACKGROUND: The Bcl-6 gene product, a nuclear phosphoprotein, is expressed independently of Bcl-6 gene rearrangement.
S3 398-539 Sentence denotes In lymph nodes, expression of Bcl-6 protein is restricted to germinal center (GC) B-cells and 10% to 15% of CD3/CD4+ intrafollicular T cells.
S4 540-628 Sentence denotes Interfollicular cells are negative for Bcl-6 protein, except for rare CD3+/CD4+ T cells.
S5 629-893 Sentence denotes Recently, we reported cases of angioimmunoblastic T-cell lymphoma (AITL) with hyperplastic GCs (AITL/GC), and observed that borders of enlarged GCs were ill defined, with features suggestive of an outward migration of GC cells to surrounding interfollicular zones.
S6 894-1043 Sentence denotes This prompted a study of follicular borders with Bcl-6 staining in reactive follicular hyperplasias and follicular lymphomas to compare with AITL/GC.
S7 1044-1138 Sentence denotes MATERIALS AND METHODS: Formalin-fixed paraffin sections were used for immunostaining of Bcl-6.
S8 1139-1315 Sentence denotes Six cases of AITL/GC, 12 nonspecific reactive follicular hyperplasia (FH), 7 HIV adenopathy, 10 follicular lymphoma (FL), and 8 typical AITL (ie, AITL without GC) were studied.
S9 1316-1406 Sentence denotes Double staining for Bcl-6/CD20, Bcl-6/CD3, and Bcl-6/CD57 was performed in selected cases.
S10 1407-1594 Sentence denotes RESULTS: In FH and HIV adenopathy, staining for Bcl-6 revealed densely populated GCs with well-defined and regular GC borders, whereas Bcl-6+ cells were rare in the interfollicular areas.
S11 1595-1758 Sentence denotes An occasional GC with an ill-defined border was invariably surrounded by a broad mantle zone; those with indistinct mantle zones had well-defined, regular borders.
S12 1759-1886 Sentence denotes In FL, follicles were densely populated, and their borders were irregular, with some Bcl-6+ cells in the interfollicular zones.
S13 1887-2033 Sentence denotes In AITL/GC, GCs were less dense, GC borders were ill defined and irregular, and the number of interfollicular Bcl-6+ cells was markedly increased.
S14 2034-2146 Sentence denotes Double staining revealed that these interfollicular Bcl-6+ cells in AITL/GC were Bcl6+/CD3+/CD20-/CD57- T cells.
S15 2147-2245 Sentence denotes Moreover, CD3+ intrafollicular T cells were depleted in AITL/GC, whereas they were abundant in FH.
S16 2246-2333 Sentence denotes Intrafollicular CD57+ cells did not stain for Bcl-6, and were also depleted in AITL/GC.
S17 2334-2435 Sentence denotes In typical AITL, some neoplastic cells were positive for Bcl-6, showing variable degrees of staining.
S18 2436-2606 Sentence denotes CONCLUSIONS: (1) GCs of AITL/GC differed from those of other reactive follicular hyperplasias and follicular lymphomas, and staining for Bcl-6 was useful to discern them.
S19 2607-2847 Sentence denotes (2) Intrafollicular CD3+ T cells, many of which were also positive for Bcl-6, were markedly depleted in AITL/GC, with increased interfollicular Bcl-6+/CD3+ cells, suggesting an outward migration of intrafollicular T cells in this condition.
S20 2848-2986 Sentence denotes (3) Interfollicular Bcl-6+/CD3+ cells in AITL/GC were too numerous to be accounted for by migration alone, suggesting local proliferation.
S21 2987-3110 Sentence denotes (4) Intrafollicular CD57+ cells were negative for Bcl-6, indicating heterogeneity of the intrafollicular T-cell population.
S22 3111-3223 Sentence denotes (5) Some neoplastic cells in AITL stained for Bcl-6, suggesting up-regulation of Bcl-6 expression in this tumor.