pubmed-sentences-benchmark  

PubMed:10079106 JSONTXT 14 Projects

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Id Subject Object Predicate Lexical cue
S1 0-139 Sentence denotes Selective activation and functional significance of p38alpha mitogen-activated protein kinase in lipopolysaccharide-stimulated neutrophils.
S2 140-290 Sentence denotes Activation of leukocytes by proinflammatory stimuli selectively initiates intracellular signal transduction via sequential phosphorylation of kinases.
S3 291-554 Sentence denotes Lipopolysaccharide (LPS) stimulation of human neutrophils is known to result in activation of p38 mitogen-activated protein kinase (MAPk); however, the upstream activator(s) of p38 MAPk is unknown, and consequences of p38 MAPk activation remain largely undefined.
S4 555-764 Sentence denotes We investigated the MAPk kinase (MKK) that activates p38 MAPk in response to LPS, the p38 MAPk isoforms that are activated as part of this pathway, and the functional responses affected by p38 MAPk activation.
S5 765-922 Sentence denotes Although MKK3, MKK4, and MKK6 all activated p38 MAPk in experimental models, only MKK3 was found to activate recombinant p38 MAPk in LPS-treated neutrophils.
S6 923-1009 Sentence denotes Of p38 MAPk isoforms studied, only p38alpha and p38delta were detected in neutrophils.
S7 1010-1057 Sentence denotes LPS stimulation selectively activated p38alpha.
S8 1058-1229 Sentence denotes Specific inhibitors of p38alpha MAPk blocked LPS-induced adhesion, nuclear factor-kappa B (NF-kappaB) activation, and synthesis of tumor necrosis factor-alpha (TNF-alpha).
S9 1230-1365 Sentence denotes Inhibition of p38alpha MAPk resulted in a transient decrease in TNF-alpha mRNA accumulation but persistent loss of TNF-alpha synthesis.
S10 1366-1640 Sentence denotes These findings support a pathway by which LPS stimulation of neutrophils results in activation of MKK3, which in turn activates p38alpha MAPk, ultimately regulating adhesion, NF-kappaB activation, enhanced gene expression of TNF-alpha, and regulation of TNF-alpha synthesis.