| Id |
Subject |
Object |
Predicate |
Lexical cue |
| S1 |
0-103 |
Sentence |
denotes |
Nuclear factor-kappa B activity in T cells from patients with rheumatic diseases: a preliminary report. |
| S2 |
104-282 |
Sentence |
denotes |
OBJECTIVE: The NF-kappa B/Rel family of transcription factors regulates the expression of many genes involved in the immune or inflammatory response at the transcriptional level. |
| S3 |
283-421 |
Sentence |
denotes |
The aim of this study was to determine whether distinctive patterns of NF-kappa B activation are seen in different forms of joint disease. |
| S4 |
422-692 |
Sentence |
denotes |
METHODS: The DNA binding activity of these nucleoproteins was examined in purified synovial and peripheral T cells from patients with various chronic rheumatic diseases (12: four with rheumatoid arthritis; five with spondyloarthropathies; and three with osteoarthritis). |
| S5 |
693-971 |
Sentence |
denotes |
RESULTS: Electrophoretic mobility shift assays disclosed two specific complexes bound to a NF-kappa B specific 32P-labelled oligonucleotide in nucleoproteins extracted from purified T cells isolated from synovial fluid and peripheral blood of patients with rheumatoid arthritis. |
| S6 |
972-1043 |
Sentence |
denotes |
The complexes consisted of p50/p50 homodimers and p50/p65 heterodimers. |
| S7 |
1044-1144 |
Sentence |
denotes |
Increased NF-kappa B binding to DNA in synovial T cells was observed relative to peripheral T cells. |
| S8 |
1145-1263 |
Sentence |
denotes |
In non-rheumatoid arthritis, binding of NF-kappa B in synovial T cells was exclusively mediated by p50/p50 homodimers. |
| S9 |
1264-1419 |
Sentence |
denotes |
CONCLUSION: Overall, the results suggest that NF-kappa B may play a central part in the activation of infiltrating T cells in chronic rheumatoid arthritis. |
| S10 |
1420-1620 |
Sentence |
denotes |
The activation of this nuclear factor is qualitatively different in rheumatoid synovial T cells to that in other forms of non-rheumatoid arthritis (for example, osteoarthritis, spondyloarthropathies). |
