
PMC:3586680 / 89-1077 21 Projects
Annnotations
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T177 | 0-5 | NN | denotes | Tumor |
T178 | 6-16 | NN | denotes | suppressor |
T179 | 17-20 | NN | denotes | p53 |
T180 | 21-24 | VB | denotes | are |
T181 | 25-35 | RB | denotes | frequently |
T182 | 36-43 | VB | denotes | mutated |
T183 | 44-46 | IN | denotes | in |
T184 | 47-60 | NN | denotes | glioblastomas |
T185 | 61-62 | -LRB- | denotes | ( |
T186 | 62-66 | NN | denotes | GBMs |
T187 | 66-67 | -RRB- | denotes | ) |
T188 | 68-71 | CC | denotes | and |
T189 | 72-79 | VB | denotes | appears |
T190 | 80-82 | TO | denotes | to |
T191 | 83-93 | VB | denotes | contribute |
T192 | 93-94 | -COMMA- | denotes | , |
T193 | 95-97 | IN | denotes | in |
T194 | 98-102 | NN | denotes | part |
T195 | 102-103 | -COMMA- | denotes | , |
T196 | 104-106 | TO | denotes | to |
T197 | 107-117 | NN | denotes | resistance |
T198 | 118-120 | TO | denotes | to |
T199 | 121-133 | NN | denotes | temozolomide |
T200 | 134-135 | -LRB- | denotes | ( |
T201 | 135-138 | NN | denotes | TMZ |
T202 | 138-139 | -RRB- | denotes | ) |
T203 | 140-143 | CC | denotes | and |
T204 | 144-155 | JJ | denotes | therapeutic |
T205 | 156-161 | NN | denotes | drugs |
T206 | 163-165 | JJ | denotes | WW |
T207 | 166-183 | JJ | denotes | domain-containing |
T208 | 184-198 | NN | denotes | oxidoreductase |
T209 | 199-203 | NN | denotes | WWOX |
T210 | 204-205 | -LRB- | denotes | ( |
T211 | 205-208 | NN | denotes | FOR |
T212 | 209-211 | CC | denotes | or |
T213 | 212-216 | NN | denotes | WOX1 |
T214 | 216-217 | -RRB- | denotes | ) |
T215 | 218-220 | VB | denotes | is |
T216 | 221-222 | DT | denotes | a |
T217 | 223-235 | JJ | denotes | proapoptotic |
T218 | 236-243 | NN | denotes | protein |
T219 | 244-247 | CC | denotes | and |
T220 | 248-250 | VB | denotes | is |
T221 | 251-261 | VB | denotes | considered |
T222 | 262-264 | IN | denotes | as |
T223 | 265-266 | DT | denotes | a |
T224 | 267-272 | NN | denotes | tumor |
T225 | 273-283 | NN | denotes | suppressor |
T226 | 285-289 | NN | denotes | Loss |
T227 | 290-292 | IN | denotes | of |
T228 | 293-297 | NN | denotes | WWOX |
T229 | 298-302 | NN | denotes | gene |
T230 | 303-313 | NN | denotes | expression |
T231 | 314-316 | VB | denotes | is |
T232 | 317-327 | RB | denotes | frequently |
T233 | 328-332 | VB | denotes | seen |
T234 | 333-335 | IN | denotes | in |
T235 | 336-345 | JJ | denotes | malignant |
T236 | 346-352 | NN | denotes | cancer |
T237 | 353-358 | NN | denotes | cells |
T238 | 359-362 | JJ | denotes | due |
T239 | 363-365 | TO | denotes | to |
T240 | 366-374 | NN | denotes | promoter |
T241 | 375-391 | NN | denotes | hypermethylation |
T242 | 391-392 | -COMMA- | denotes | , |
T243 | 393-400 | JJ | denotes | genetic |
T244 | 401-412 | NN | denotes | alterations |
T245 | 412-413 | -COMMA- | denotes | , |
T246 | 414-417 | CC | denotes | and |
T247 | 418-431 | JJ | denotes | translational |
T248 | 432-440 | NN | denotes | blockade |
T249 | 442-454 | RB | denotes | Intriguingly |
T250 | 454-455 | -COMMA- | denotes | , |
T251 | 456-463 | JJ | denotes | ectopic |
T252 | 464-474 | NN | denotes | expression |
T253 | 475-477 | IN | denotes | of |
T254 | 478-482 | JJ | denotes | wild |
T255 | 483-487 | NN | denotes | type |
T256 | 488-492 | NN | denotes | WWOX |
T257 | 493-507 | RB | denotes | preferentially |
T258 | 508-515 | VB | denotes | induces |
T259 | 516-525 | NN | denotes | apoptosis |
T260 | 526-528 | IN | denotes | in |
T261 | 529-534 | JJ | denotes | human |
T262 | 535-547 | NN | denotes | glioblastoma |
T263 | 548-553 | NN | denotes | cells |
T264 | 554-563 | VB | denotes | harboring |
T265 | 564-570 | JJ | denotes | mutant |
T266 | 571-574 | NN | denotes | p53 |
T267 | 576-580 | NN | denotes | WWOX |
T268 | 581-583 | VB | denotes | is |
T269 | 584-589 | VB | denotes | known |
T270 | 590-592 | TO | denotes | to |
T271 | 593-603 | RB | denotes | physically |
T272 | 604-608 | VB | denotes | bind |
T273 | 609-612 | CC | denotes | and |
T274 | 613-622 | VB | denotes | stabilize |
T275 | 623-627 | JJ | denotes | wild |
T276 | 628-632 | NN | denotes | type |
T277 | 633-636 | NN | denotes | p53 |
T278 | 638-642 | RB | denotes | Here |
T279 | 642-643 | -COMMA- | denotes | , |
T280 | 644-646 | PRP | denotes | we |
T281 | 647-654 | VB | denotes | provide |
T282 | 655-657 | DT | denotes | an |
T283 | 658-666 | NN | denotes | overview |
T284 | 667-670 | IN | denotes | for |
T285 | 671-674 | DT | denotes | the |
T286 | 675-682 | VB | denotes | updated |
T287 | 683-692 | NN | denotes | knowledge |
T288 | 693-695 | IN | denotes | in |
T289 | 696-699 | NN | denotes | p53 |
T290 | 700-703 | CC | denotes | and |
T291 | 704-708 | NN | denotes | WWOX |
T292 | 708-709 | -COMMA- | denotes | , |
T293 | 710-713 | CC | denotes | and |
T294 | 714-723 | VB | denotes | postulate |
T295 | 724-733 | JJ | denotes | potential |
T296 | 734-743 | NN | denotes | scenarios |
T297 | 744-748 | IN | denotes | that |
T298 | 749-753 | JJ | denotes | wild |
T299 | 754-758 | NN | denotes | type |
T300 | 759-762 | CC | denotes | and |
T301 | 763-769 | JJ | denotes | mutant |
T302 | 770-773 | NN | denotes | p53 |
T303 | 773-774 | -COMMA- | denotes | , |
T304 | 775-777 | CC | denotes | or |
T305 | 778-786 | NN | denotes | isoforms |
T306 | 786-787 | -COMMA- | denotes | , |
T307 | 788-796 | VB | denotes | modulate |
T308 | 797-800 | DT | denotes | the |
T309 | 801-810 | JJ | denotes | apoptotic |
T310 | 811-819 | NN | denotes | function |
T311 | 820-822 | IN | denotes | of |
T312 | 823-827 | NN | denotes | WWOX |
T313 | 829-831 | PRP | denotes | We |
T314 | 832-839 | VB | denotes | propose |
T315 | 840-844 | IN | denotes | that |
T316 | 845-855 | VB | denotes | triggering |
T317 | 856-860 | NN | denotes | WWOX |
T318 | 861-871 | NN | denotes | activation |
T319 | 872-874 | IN | denotes | by |
T320 | 875-886 | JJ | denotes | therapeutic |
T321 | 887-892 | NN | denotes | drugs |
T322 | 893-898 | IN | denotes | under |
T323 | 899-902 | NN | denotes | p53 |
T324 | 903-913 | JJ | denotes | functional |
T325 | 914-924 | NN | denotes | deficiency |
T326 | 925-927 | VB | denotes | is |
T327 | 928-934 | VB | denotes | needed |
T328 | 935-937 | TO | denotes | to |
T329 | 938-946 | VB | denotes | overcome |
T330 | 947-950 | NN | denotes | TMZ |
T331 | 951-961 | NN | denotes | resistance |
T332 | 962-965 | CC | denotes | and |
T333 | 966-972 | VB | denotes | induce |
T334 | 973-976 | NN | denotes | GBM |
T335 | 977-981 | NN | denotes | cell |
T336 | 982-987 | NN | denotes | death |
R100 | T237 | T234 | arg2Of | cells,in |
R101 | T237 | T235 | arg1Of | cells,malignant |
R102 | T237 | T236 | arg1Of | cells,cancer |
R103 | T237 | T238 | arg1Of | cells,due |
R104 | T241 | T240 | arg1Of | hypermethylation,promoter |
R105 | T241 | T242 | arg1Of | hypermethylation,"," |
R106 | T242 | T246 | arg1Of | ",",and |
R107 | T244 | T242 | arg2Of | alterations,"," |
R108 | T244 | T243 | arg1Of | alterations,genetic |
R109 | T246 | T239 | arg2Of | and,to |
R110 | T246 | T245 | arg1Of | and,"," |
R111 | T248 | T246 | arg2Of | blockade,and |
R112 | T248 | T247 | arg1Of | blockade,translational |
R113 | T252 | T251 | arg1Of | expression,ectopic |
R114 | T252 | T253 | arg1Of | expression,of |
R115 | T252 | T258 | arg1Of | expression,induces |
R116 | T256 | T253 | arg2Of | WWOX,of |
R117 | T256 | T254 | arg1Of | WWOX,wild |
R118 | T256 | T255 | arg1Of | WWOX,type |
R119 | T258 | T249 | arg1Of | induces,Intriguingly |
R120 | T258 | T250 | arg1Of | induces,"," |
R121 | T258 | T257 | arg1Of | induces,preferentially |
R122 | T258 | T260 | arg1Of | induces,in |
R123 | T259 | T258 | arg2Of | apoptosis,induces |
R124 | T263 | T260 | arg2Of | cells,in |
R125 | T263 | T261 | arg1Of | cells,human |
R126 | T263 | T262 | arg1Of | cells,glioblastoma |
R127 | T263 | T264 | arg1Of | cells,harboring |
R128 | T266 | T264 | arg2Of | p53,harboring |
R129 | T266 | T265 | arg1Of | p53,mutant |
R130 | T267 | T268 | arg1Of | WWOX,is |
R131 | T267 | T269 | arg2Of | WWOX,known |
R132 | T267 | T272 | arg1Of | WWOX,bind |
R133 | T267 | T274 | arg1Of | WWOX,stabilize |
R134 | T269 | T268 | arg2Of | known,is |
R135 | T272 | T273 | arg1Of | bind,and |
R136 | T273 | T269 | arg3Of | and,known |
R137 | T273 | T270 | arg1Of | and,to |
R138 | T273 | T271 | arg1Of | and,physically |
R139 | T274 | T273 | arg2Of | stabilize,and |
R140 | T277 | T272 | arg2Of | p53,bind |
R141 | T277 | T274 | arg2Of | p53,stabilize |
R142 | T277 | T275 | arg1Of | p53,wild |
R143 | T277 | T276 | arg1Of | p53,type |
R144 | T280 | T281 | arg1Of | we,provide |
R145 | T280 | T294 | arg1Of | we,postulate |
R146 | T281 | T293 | arg1Of | provide,and |
R147 | T283 | T281 | arg2Of | overview,provide |
R148 | T283 | T282 | arg1Of | overview,an |
R149 | T283 | T284 | arg1Of | overview,for |
R150 | T287 | T284 | arg2Of | knowledge,for |
R151 | T287 | T285 | arg1Of | knowledge,the |
R152 | T287 | T286 | arg2Of | knowledge,updated |
R153 | T287 | T288 | arg1Of | knowledge,in |
R154 | T289 | T290 | arg1Of | p53,and |
R155 | T290 | T288 | arg2Of | and,in |
R156 | T291 | T290 | arg2Of | WWOX,and |
R157 | T293 | T278 | arg1Of | and,Here |
R158 | T293 | T279 | arg1Of | and,"," |
R159 | T293 | T292 | arg1Of | and,"," |
R160 | T294 | T293 | arg2Of | postulate,and |
R161 | T296 | T294 | arg2Of | scenarios,postulate |
R162 | T296 | T295 | arg1Of | scenarios,potential |
R163 | T296 | T297 | arg1Of | scenarios,that |
R164 | T299 | T298 | arg1Of | type,wild |
R165 | T299 | T300 | arg1Of | type,and |
R166 | T300 | T304 | arg1Of | and,or |
R167 | T302 | T300 | arg2Of | p53,and |
R168 | T302 | T301 | arg1Of | p53,mutant |
R169 | T304 | T303 | arg1Of | or,"," |
R170 | T304 | T307 | arg1Of | or,modulate |
R171 | T305 | T304 | arg2Of | isoforms,or |
R172 | T307 | T297 | arg2Of | modulate,that |
R173 | T307 | T306 | arg1Of | modulate,"," |
R174 | T310 | T307 | arg2Of | function,modulate |
R175 | T310 | T308 | arg1Of | function,the |
R176 | T310 | T309 | arg1Of | function,apoptotic |
R177 | T310 | T311 | arg1Of | function,of |
R178 | T312 | T311 | arg2Of | WWOX,of |
R179 | T313 | T314 | arg1Of | We,propose |
R180 | T318 | T316 | arg1Of | activation,triggering |
R181 | T318 | T317 | arg1Of | activation,WWOX |
R182 | T318 | T319 | arg1Of | activation,by |
R183 | T318 | T322 | arg1Of | activation,under |
R184 | T318 | T326 | arg1Of | activation,is |
R185 | T318 | T327 | arg2Of | activation,needed |
R186 | T321 | T319 | arg2Of | drugs,by |
R187 | T321 | T320 | arg1Of | drugs,therapeutic |
R188 | T325 | T322 | arg2Of | deficiency,under |
R189 | T325 | T323 | arg1Of | deficiency,p53 |
R190 | T325 | T324 | arg1Of | deficiency,functional |
R191 | T327 | T314 | arg2Of | needed,propose |
R192 | T327 | T315 | arg1Of | needed,that |
R193 | T327 | T326 | arg2Of | needed,is |
R194 | T327 | T328 | modOf | needed,to |
R195 | T329 | T332 | arg1Of | overcome,and |
R196 | T331 | T329 | arg2Of | resistance,overcome |
R197 | T331 | T330 | arg1Of | resistance,TMZ |
R198 | T332 | T328 | arg1Of | and,to |
R199 | T333 | T332 | arg2Of | induce,and |
R200 | T336 | T333 | arg2Of | death,induce |
R201 | T336 | T334 | arg1Of | death,GBM |
R202 | T336 | T335 | arg1Of | death,cell |
R38 | T179 | T177 | arg1Of | p53,Tumor |
R39 | T179 | T178 | arg1Of | p53,suppressor |
R40 | T179 | T180 | arg1Of | p53,are |
R41 | T179 | T182 | arg2Of | p53,mutated |
R42 | T179 | T189 | arg1Of | p53,appears |
R43 | T179 | T191 | arg1Of | p53,contribute |
R44 | T182 | T180 | arg2Of | mutated,are |
R45 | T182 | T181 | arg1Of | mutated,frequently |
R46 | T182 | T183 | arg1Of | mutated,in |
R47 | T182 | T188 | arg1Of | mutated,and |
R48 | T184 | T183 | arg2Of | glioblastomas,in |
R49 | T184 | T185 | arg1Of | glioblastomas,( |
R50 | T186 | T185 | arg2Of | GBMs,( |
R51 | T187 | T185 | arg3Of | ),( |
R52 | T189 | T188 | arg2Of | appears,and |
R53 | T191 | T189 | arg2Of | contribute,appears |
R54 | T191 | T190 | arg1Of | contribute,to |
R55 | T191 | T192 | arg1Of | contribute,"," |
R56 | T191 | T193 | arg1Of | contribute,in |
R57 | T191 | T195 | arg1Of | contribute,"," |
R58 | T191 | T196 | arg1Of | contribute,to |
R59 | T194 | T193 | arg2Of | part,in |
R60 | T197 | T198 | arg1Of | resistance,to |
R61 | T197 | T203 | arg1Of | resistance,and |
R62 | T199 | T198 | arg2Of | temozolomide,to |
R63 | T199 | T200 | arg1Of | temozolomide,( |
R64 | T201 | T200 | arg2Of | TMZ,( |
R65 | T202 | T200 | arg3Of | ),( |
R66 | T203 | T196 | arg2Of | and,to |
R67 | T205 | T203 | arg2Of | drugs,and |
R68 | T205 | T204 | arg1Of | drugs,therapeutic |
R69 | T209 | T206 | arg1Of | WWOX,WW |
R70 | T209 | T207 | arg1Of | WWOX,domain-containing |
R71 | T209 | T208 | arg1Of | WWOX,oxidoreductase |
R72 | T209 | T210 | arg1Of | WWOX,( |
R73 | T209 | T215 | arg1Of | WWOX,is |
R74 | T209 | T220 | arg1Of | WWOX,is |
R75 | T209 | T221 | arg2Of | WWOX,considered |
R76 | T211 | T212 | arg1Of | FOR,or |
R77 | T212 | T210 | arg2Of | or,( |
R78 | T213 | T212 | arg2Of | WOX1,or |
R79 | T214 | T210 | arg3Of | ),( |
R80 | T215 | T219 | arg1Of | is,and |
R81 | T218 | T215 | arg2Of | protein,is |
R82 | T218 | T216 | arg1Of | protein,a |
R83 | T218 | T217 | arg1Of | protein,proapoptotic |
R84 | T221 | T219 | arg2Of | considered,and |
R85 | T221 | T220 | arg2Of | considered,is |
R86 | T221 | T222 | arg1Of | considered,as |
R87 | T225 | T222 | arg2Of | suppressor,as |
R88 | T225 | T223 | arg1Of | suppressor,a |
R89 | T225 | T224 | arg1Of | suppressor,tumor |
R90 | T226 | T227 | arg1Of | Loss,of |
R91 | T226 | T231 | arg1Of | Loss,is |
R92 | T226 | T233 | arg2Of | Loss,seen |
R93 | T230 | T227 | arg2Of | expression,of |
R94 | T230 | T228 | arg1Of | expression,WWOX |
R95 | T230 | T229 | arg1Of | expression,gene |
R96 | T233 | T231 | arg2Of | seen,is |
R97 | T233 | T232 | arg1Of | seen,frequently |
R98 | T233 | T234 | arg1Of | seen,in |
R99 | T233 | T239 | arg1Of | seen,to |