Id |
Subject |
Object |
Predicate |
Lexical cue |
T8540 |
33-36 |
NN |
denotes |
p53 |
T8541 |
37-44 |
NN |
denotes |
mutants |
T8542 |
45-48 |
VB |
denotes |
are |
T8543 |
49-59 |
VB |
denotes |
considered |
T8544 |
60-62 |
IN |
denotes |
as |
T8545 |
63-74 |
JJ |
denotes |
unfavorable |
T8546 |
75-82 |
NN |
denotes |
factors |
T8547 |
83-86 |
IN |
denotes |
for |
T8548 |
87-90 |
DT |
denotes |
the |
T8549 |
91-104 |
NN |
denotes |
effectiveness |
T8550 |
105-107 |
IN |
denotes |
in |
T8551 |
108-120 |
NN |
denotes |
radiotherapy |
T8552 |
121-124 |
CC |
denotes |
and |
T8553 |
125-128 |
NN |
denotes |
TMZ |
T8554 |
129-138 |
NN |
denotes |
treatment |
T8555 |
139-141 |
IN |
denotes |
in |
T8556 |
142-148 |
NN |
denotes |
glioma |
T8557 |
149-154 |
NN |
denotes |
cells |
T8558 |
155-156 |
-LRB- |
denotes |
( |
T8559 |
156-163 |
NN |
denotes |
Gjerset |
T8560 |
164-166 |
FW |
denotes |
et |
T8561 |
167-170 |
FW |
denotes |
al. |
T8562 |
170-171 |
-COMMA- |
denotes |
, |
T8563 |
172-176 |
CD |
denotes |
1995 |
T8564 |
176-177 |
-COLON- |
denotes |
; |
T8565 |
178-184 |
NNP |
denotes |
Hirose |
T8566 |
185-187 |
FW |
denotes |
et |
T8567 |
188-191 |
FW |
denotes |
al. |
T8568 |
191-192 |
-COMMA- |
denotes |
, |
T8569 |
193-197 |
CD |
denotes |
2001 |
T8570 |
197-198 |
-COLON- |
denotes |
; |
T8571 |
199-208 |
NNP |
denotes |
Squatrito |
T8572 |
209-211 |
FW |
denotes |
et |
T8573 |
212-215 |
FW |
denotes |
al. |
T8574 |
215-216 |
-COMMA- |
denotes |
, |
T8575 |
217-221 |
CD |
denotes |
2010 |
T8576 |
221-222 |
-COLON- |
denotes |
; |
T8577 |
223-229 |
NNP |
denotes |
Blough |
T8578 |
230-232 |
FW |
denotes |
et |
T8579 |
233-236 |
FW |
denotes |
al. |
T8580 |
236-237 |
-COMMA- |
denotes |
, |
T8581 |
238-242 |
CD |
denotes |
2011 |
T8582 |
242-243 |
-RRB- |
denotes |
) |
T8583 |
245-249 |
NN |
denotes |
Loss |
T8584 |
250-252 |
IN |
denotes |
of |
T8585 |
253-263 |
JJ |
denotes |
functional |
T8586 |
264-267 |
NN |
denotes |
p53 |
T8587 |
268-275 |
VB |
denotes |
confers |
T8588 |
276-287 |
NN |
denotes |
sensitivity |
T8589 |
288-290 |
TO |
denotes |
to |
T8590 |
291-294 |
NN |
denotes |
TMZ |
T8591 |
295-297 |
IN |
denotes |
in |
T8592 |
298-304 |
NN |
denotes |
glioma |
T8593 |
305-310 |
NN |
denotes |
cells |
T8594 |
310-311 |
-COMMA- |
denotes |
, |
T8595 |
312-319 |
IN |
denotes |
whereas |
T8596 |
320-324 |
JJ |
denotes |
wild |
T8597 |
325-329 |
NN |
denotes |
type |
T8598 |
330-333 |
NN |
denotes |
p53 |
T8599 |
334-343 |
VB |
denotes |
increases |
T8600 |
344-347 |
DT |
denotes |
the |
T8601 |
348-351 |
NN |
denotes |
TMZ |
T8602 |
352-362 |
NN |
denotes |
resistance |
T8603 |
363-364 |
-LRB- |
denotes |
( |
T8604 |
364-370 |
NNP |
denotes |
Blough |
T8605 |
371-373 |
FW |
denotes |
et |
T8606 |
374-377 |
FW |
denotes |
al. |
T8607 |
377-378 |
-COMMA- |
denotes |
, |
T8608 |
379-383 |
CD |
denotes |
2011 |
T8609 |
383-384 |
-RRB- |
denotes |
) |
T8610 |
384-387 |
NN |
denotes |
. p |
T8611 |
387-394 |
NN |
denotes |
53 muta |
T8612 |
394-400 |
VB |
denotes |
nts re |
T8613 |
400-403 |
NN |
denotes |
duc |
T8614 |
403-414 |
NN |
denotes |
e TMZ sensi |
T8615 |
414-416 |
IN |
denotes |
ti |
T8616 |
416-423 |
NN |
denotes |
vity in |
T8617 |
424-425 |
-LRB- |
denotes |
g |
T8618 |
425-431 |
NNP |
denotes |
liomas |
T8619 |
432-434 |
FW |
denotes |
(B |
T8620 |
434-437 |
FW |
denotes |
lou |
T8621 |
437-438 |
-COMMA- |
denotes |
g |
T8622 |
438-442 |
CD |
denotes |
h et |
T8623 |
443-444 |
-RRB- |
denotes |
a |
T8624 |
455-462 |
VB |
denotes |
Altered |
T8625 |
463-467 |
NN |
denotes |
WWOX |
T8626 |
468-478 |
NN |
denotes |
expression |
T8627 |
479-481 |
VB |
denotes |
is |
T8628 |
482-487 |
VB |
denotes |
shown |
T8629 |
488-490 |
IN |
denotes |
in |
T8630 |
491-495 |
NN |
denotes |
GBMs |
T8631 |
495-496 |
-COMMA- |
denotes |
, |
T8632 |
497-499 |
IN |
denotes |
in |
T8633 |
500-505 |
WDT |
denotes |
which |
T8634 |
506-520 |
NN |
denotes |
downregulation |
T8635 |
521-523 |
IN |
denotes |
of |
T8636 |
524-528 |
NN |
denotes |
WWOX |
T8637 |
529-531 |
VB |
denotes |
is |
T8638 |
532-542 |
VB |
denotes |
associated |
T8639 |
543-547 |
IN |
denotes |
with |
T8640 |
548-552 |
NN |
denotes |
loss |
T8641 |
553-555 |
IN |
denotes |
of |
T8642 |
556-570 |
NN |
denotes |
heterozygosity |
T8643 |
571-574 |
CC |
denotes |
and |
T8644 |
575-583 |
NN |
denotes |
promoter |
T8645 |
584-595 |
NN |
denotes |
methylation |
T8646 |
596-597 |
-LRB- |
denotes |
( |
T8647 |
597-602 |
NNP |
denotes |
Kosla |
T8648 |
603-605 |
FW |
denotes |
et |
T8649 |
606-609 |
FW |
denotes |
al. |
T8650 |
609-610 |
-COMMA- |
denotes |
, |
T8651 |
611-615 |
CD |
denotes |
2011 |
T8652 |
615-616 |
-RRB- |
denotes |
) |
T8653 |
618-626 |
RB |
denotes |
Recently |
T8654 |
626-627 |
-COMMA- |
denotes |
, |
T8655 |
628-630 |
PRP |
denotes |
we |
T8656 |
631-643 |
VB |
denotes |
demonstrated |
T8657 |
644-648 |
IN |
denotes |
that |
T8658 |
649-662 |
VB |
denotes |
overexpressed |
T8659 |
663-667 |
NN |
denotes |
WWOX |
T8660 |
668-675 |
VB |
denotes |
induces |
T8661 |
676-685 |
NN |
denotes |
apoptosis |
T8662 |
686-688 |
IN |
denotes |
of |
T8663 |
689-701 |
NN |
denotes |
glioblastoma |
T8664 |
702-709 |
NN |
denotes |
U373-MG |
T8665 |
710-715 |
NN |
denotes |
cells |
T8666 |
716-725 |
VB |
denotes |
harboring |
T8667 |
726-732 |
JJ |
denotes |
mutant |
T8668 |
733-736 |
NN |
denotes |
p53 |
T8669 |
737-739 |
IN |
denotes |
by |
T8670 |
740-747 |
VB |
denotes |
causing |
T8671 |
748-758 |
NN |
denotes |
hypoploidy |
T8672 |
759-762 |
CC |
denotes |
and |
T8673 |
763-766 |
NN |
denotes |
DNA |
T8674 |
767-780 |
NN |
denotes |
fragmentation |
T8675 |
781-782 |
-LRB- |
denotes |
( |
T8676 |
782-788 |
NNP |
denotes |
Chiang |
T8677 |
789-791 |
FW |
denotes |
et |
T8678 |
792-795 |
FW |
denotes |
al. |
T8679 |
795-796 |
-COMMA- |
denotes |
, |
T8680 |
797-801 |
CD |
denotes |
2012 |
T8681 |
801-802 |
-RRB- |
denotes |
) |
T8682 |
804-811 |
RB |
denotes |
However |
T8683 |
811-812 |
-COMMA- |
denotes |
, |
T8684 |
813-820 |
JJ |
denotes |
ectopic |
T8685 |
821-825 |
NN |
denotes |
WWOX |
T8686 |
826-829 |
VB |
denotes |
has |
T8687 |
830-832 |
DT |
denotes |
no |
T8688 |
833-839 |
NN |
denotes |
effect |
T8689 |
840-844 |
IN |
denotes |
with |
T8690 |
845-851 |
NN |
denotes |
U87-MG |
T8691 |
852-862 |
VB |
denotes |
expressing |
T8692 |
863-867 |
JJ |
denotes |
wild |
T8693 |
868-872 |
NN |
denotes |
type |
T8694 |
873-876 |
NN |
denotes |
p53 |
T8695 |
878-884 |
IN |
denotes |
Unlike |
T8696 |
885-888 |
NN |
denotes |
TMZ |
T8697 |
888-889 |
-COMMA- |
denotes |
, |
T8698 |
890-894 |
NN |
denotes |
WWOX |
T8699 |
895-902 |
VB |
denotes |
induces |
T8700 |
903-912 |
NN |
denotes |
apoptosis |
T8701 |
913-915 |
IN |
denotes |
of |
T8702 |
916-923 |
NN |
denotes |
U373-MG |
T8703 |
924-929 |
NN |
denotes |
cells |
T8704 |
930-933 |
IN |
denotes |
via |
T8705 |
934-935 |
DT |
denotes |
a |
T8706 |
936-960 |
JJ |
denotes |
mitochondria-independent |
T8707 |
961-964 |
CC |
denotes |
and |
T8708 |
965-986 |
JJ |
denotes |
caspase-3-independent |
T8709 |
987-994 |
NN |
denotes |
pathway |
T8710 |
995-996 |
-LRB- |
denotes |
( |
T8711 |
996-1002 |
NNP |
denotes |
Chiang |
T8712 |
1003-1005 |
FW |
denotes |
et |
T8713 |
1006-1009 |
FW |
denotes |
al. |
T8714 |
1009-1010 |
-COMMA- |
denotes |
, |
T8715 |
1011-1015 |
CD |
denotes |
2012 |
T8716 |
1015-1016 |
-RRB- |
denotes |
) |
T8717 |
1018-1023 |
IN |
denotes |
While |
T8718 |
1024-1027 |
DT |
denotes |
the |
T8719 |
1028-1038 |
VB |
denotes |
underlying |
T8720 |
1039-1049 |
NN |
denotes |
mechanisms |
T8721 |
1050-1053 |
VB |
denotes |
are |
T8722 |
1054-1061 |
JJ |
denotes |
unknown |
T8723 |
1061-1062 |
-COMMA- |
denotes |
, |
T8724 |
1063-1065 |
PRP |
denotes |
it |
T8725 |
1066-1068 |
VB |
denotes |
is |
T8726 |
1069-1079 |
JJ |
denotes |
reasonable |
T8727 |
1080-1082 |
TO |
denotes |
to |
T8728 |
1083-1089 |
VB |
denotes |
assume |
T8729 |
1090-1094 |
IN |
denotes |
that |
T8730 |
1095-1098 |
DT |
denotes |
the |
T8731 |
1099-1107 |
NN |
denotes |
survival |
T8732 |
1108-1110 |
IN |
denotes |
of |
T8733 |
1111-1116 |
JJ |
denotes |
human |
T8734 |
1117-1129 |
NN |
denotes |
glioblastoma |
T8735 |
1130-1135 |
NN |
denotes |
cells |
T8736 |
1136-1143 |
VB |
denotes |
depends |
T8737 |
1144-1148 |
IN |
denotes |
upon |
T8738 |
1149-1161 |
NN |
denotes |
interactions |
T8739 |
1162-1169 |
IN |
denotes |
between |
T8740 |
1170-1173 |
DT |
denotes |
the |
T8741 |
1174-1190 |
NN |
denotes |
gain-of-function |
T8742 |
1191-1193 |
IN |
denotes |
of |
T8743 |
1194-1197 |
NN |
denotes |
p53 |
T8744 |
1198-1205 |
NN |
denotes |
mutants |
T8745 |
1206-1209 |
CC |
denotes |
and |
T8746 |
1210-1214 |
NN |
denotes |
WWOX |
T8747 |
1216-1225 |
VB |
denotes |
Activated |
T8748 |
1226-1230 |
NN |
denotes |
WWOX |
T8749 |
1231-1236 |
VB |
denotes |
binds |
T8750 |
1237-1241 |
JJ |
denotes |
wild |
T8751 |
1242-1246 |
NN |
denotes |
type |
T8752 |
1247-1250 |
NN |
denotes |
p53 |
T8753 |
1251-1255 |
IN |
denotes |
with |
T8754 |
1256-1261 |
NN |
denotes |
Ser46 |
T8755 |
1262-1277 |
NN |
denotes |
phosphorylation |
T8756 |
1278-1279 |
-LRB- |
denotes |
( |
T8757 |
1279-1284 |
NNP |
denotes |
Chang |
T8758 |
1285-1287 |
FW |
denotes |
et |
T8759 |
1288-1291 |
FW |
denotes |
al. |
T8760 |
1291-1292 |
-COMMA- |
denotes |
, |
T8761 |
1293-1298 |
NN |
denotes |
2005b |
T8762 |
1298-1299 |
-RRB- |
denotes |
) |
T8763 |
1301-1303 |
NN |
denotes |
UV |
T8764 |
1304-1315 |
NN |
denotes |
irradiation |
T8765 |
1316-1324 |
VB |
denotes |
enhances |
T8766 |
1325-1328 |
DT |
denotes |
the |
T8767 |
1329-1336 |
NN |
denotes |
binding |
T8768 |
1337-1349 |
NN |
denotes |
interactions |
T8769 |
1351-1358 |
IN |
denotes |
Despite |
T8770 |
1359-1362 |
DT |
denotes |
the |
T8771 |
1363-1371 |
NN |
denotes |
presence |
T8772 |
1372-1374 |
IN |
denotes |
of |
T8773 |
1375-1380 |
NN |
denotes |
Ser46 |
T8774 |
1381-1383 |
IN |
denotes |
in |
T8775 |
1384-1390 |
NN |
denotes |
Δ40p53 |
T8776 |
1390-1391 |
-COMMA- |
denotes |
, |
T8777 |
1392-1399 |
NN |
denotes |
binding |
T8778 |
1400-1402 |
IN |
denotes |
of |
T8779 |
1403-1407 |
DT |
denotes |
this |
T8780 |
1408-1415 |
NN |
denotes |
protein |
T8781 |
1416-1420 |
IN |
denotes |
with |
T8782 |
1421-1425 |
NN |
denotes |
WWOX |
T8783 |
1426-1433 |
VB |
denotes |
remains |
T8784 |
1434-1436 |
TO |
denotes |
to |
T8785 |
1437-1439 |
VB |
denotes |
be |
T8786 |
1440-1450 |
VB |
denotes |
determined |
T8787 |
1452-1454 |
PRP |
denotes |
We |
T8788 |
1455-1464 |
VB |
denotes |
postulate |
T8789 |
1465-1469 |
IN |
denotes |
that |
T8790 |
1470-1472 |
IN |
denotes |
in |
T8791 |
1473-1476 |
NN |
denotes |
GBM |
T8792 |
1477-1482 |
NN |
denotes |
cells |
T8793 |
1482-1483 |
-COMMA- |
denotes |
, |
T8794 |
1484-1488 |
DT |
denotes |
both |
T8795 |
1489-1493 |
JJ |
denotes |
wild |
T8796 |
1494-1498 |
NN |
denotes |
type |
T8797 |
1499-1502 |
NN |
denotes |
p53 |
T8798 |
1503-1506 |
CC |
denotes |
and |
T8799 |
1507-1514 |
JJ |
denotes |
ectopic |
T8800 |
1515-1519 |
NN |
denotes |
WWOX |
T8801 |
1520-1528 |
NN |
denotes |
proteins |
T8802 |
1529-1535 |
VB |
denotes |
appear |
T8803 |
1536-1538 |
TO |
denotes |
to |
T8804 |
1539-1543 |
VB |
denotes |
have |
T8805 |
1544-1545 |
DT |
denotes |
a |
T8806 |
1546-1556 |
JJ |
denotes |
functional |
T8807 |
1557-1567 |
NN |
denotes |
antagonism |
T8808 |
1567-1568 |
-COMMA- |
denotes |
, |
T8809 |
1569-1576 |
RB |
denotes |
thereby |
T8810 |
1577-1587 |
VB |
denotes |
nullifying |
T8811 |
1588-1592 |
DT |
denotes |
each |
T8812 |
1593-1600 |
NN |
denotes |
other’s |
T8813 |
1601-1609 |
VB |
denotes |
function |
T8814 |
1610-1612 |
IN |
denotes |
in |
T8815 |
1613-1621 |
VB |
denotes |
inducing |
T8816 |
1622-1631 |
NN |
denotes |
apoptosis |
T8817 |
1632-1633 |
-LRB- |
denotes |
( |
T8818 |
1633-1639 |
NN |
denotes |
Figure |
T8819 |
1640-1641 |
CD |
denotes |
2 |
T8820 |
1641-1642 |
-RRB- |
denotes |
) |
T8821 |
1644-1650 |
JJ |
denotes |
Mutant |
T8822 |
1651-1654 |
NN |
denotes |
p53 |
T8823 |
1655-1663 |
NN |
denotes |
proteins |
T8824 |
1664-1667 |
MD |
denotes |
can |
T8825 |
1667-1670 |
RB |
denotes |
not |
T8826 |
1671-1675 |
VB |
denotes |
bind |
T8827 |
1676-1683 |
JJ |
denotes |
ectopic |
T8828 |
1684-1688 |
NN |
denotes |
WWOX |
T8829 |
1689-1691 |
IN |
denotes |
in |
T8830 |
1692-1695 |
NN |
denotes |
GBM |
T8831 |
1696-1701 |
NN |
denotes |
cells |
T8832 |
1701-1702 |
-COMMA- |
denotes |
, |
T8833 |
1703-1706 |
CC |
denotes |
and |
T8834 |
1707-1711 |
NN |
denotes |
WWOX |
T8835 |
1712-1714 |
VB |
denotes |
is |
T8836 |
1715-1719 |
JJ |
denotes |
able |
T8837 |
1720-1722 |
TO |
denotes |
to |
T8838 |
1723-1729 |
VB |
denotes |
induce |
T8839 |
1730-1739 |
NN |
denotes |
apoptosis |
T8840 |
1741-1748 |
IN |
denotes |
Whether |
T8841 |
1749-1753 |
NN |
denotes |
WWOX |
T8842 |
1754-1760 |
VB |
denotes |
causes |
T8843 |
1761-1770 |
NN |
denotes |
apoptosis |
T8844 |
1771-1773 |
IN |
denotes |
in |
T8845 |
1774-1777 |
NN |
denotes |
GBM |
T8846 |
1778-1788 |
VB |
denotes |
expressing |
T8847 |
1789-1792 |
NN |
denotes |
p53 |
T8848 |
1793-1801 |
NN |
denotes |
isoforms |
T8849 |
1802-1804 |
VB |
denotes |
is |
T8850 |
1805-1812 |
JJ |
denotes |
unknown |
T8851 |
1813-1816 |
CC |
denotes |
and |
T8852 |
1817-1824 |
VB |
denotes |
remains |
T8853 |
1825-1827 |
TO |
denotes |
to |
T8854 |
1828-1830 |
VB |
denotes |
be |
T8855 |
1831-1842 |
VB |
denotes |
established |
R5812 |
T8541 |
T8540 |
arg1Of |
mutants,p53 |
R5813 |
T8541 |
T8542 |
arg1Of |
mutants,are |
R5814 |
T8541 |
T8543 |
arg2Of |
mutants,considered |
R5815 |
T8543 |
T8542 |
arg2Of |
considered,are |
R5816 |
T8543 |
T8544 |
arg1Of |
considered,as |
R5817 |
T8543 |
T8555 |
arg1Of |
considered,in |
R5818 |
T8546 |
T8544 |
arg2Of |
factors,as |
R5819 |
T8546 |
T8545 |
arg1Of |
factors,unfavorable |
R5820 |
T8546 |
T8547 |
arg1Of |
factors,for |
R5821 |
T8549 |
T8547 |
arg2Of |
effectiveness,for |
R5822 |
T8549 |
T8548 |
arg1Of |
effectiveness,the |
R5823 |
T8549 |
T8550 |
arg1Of |
effectiveness,in |
R5824 |
T8551 |
T8552 |
arg1Of |
radiotherapy,and |
R5825 |
T8553 |
T8552 |
arg2Of |
TMZ,and |
R5826 |
T8554 |
T8550 |
arg2Of |
treatment,in |
R5827 |
T8554 |
T8551 |
arg1Of |
treatment,radiotherapy |
R5828 |
T8554 |
T8553 |
arg1Of |
treatment,TMZ |
R5829 |
T8557 |
T8555 |
arg2Of |
cells,in |
R5830 |
T8557 |
T8556 |
arg1Of |
cells,glioma |
R5831 |
T8557 |
T8558 |
arg1Of |
cells,( |
R5832 |
T8559 |
T8560 |
arg1Of |
Gjerset,et |
R5833 |
T8559 |
T8561 |
arg1Of |
Gjerset,al. |
R5834 |
T8559 |
T8562 |
arg1Of |
Gjerset,"," |
R5835 |
T8562 |
T8558 |
arg2Of |
",",( |
R5836 |
T8562 |
T8564 |
arg1Of |
",",; |
R5837 |
T8562 |
T8570 |
arg1Of |
",",; |
R5838 |
T8563 |
T8562 |
arg2Of |
1995,"," |
R5839 |
T8565 |
T8564 |
arg2Of |
Hirose,; |
R5840 |
T8565 |
T8566 |
arg1Of |
Hirose,et |
R5841 |
T8565 |
T8567 |
arg1Of |
Hirose,al. |
R5842 |
T8565 |
T8568 |
arg1Of |
Hirose,"," |
R5843 |
T8569 |
T8568 |
arg2Of |
2001,"," |
R5844 |
T8571 |
T8570 |
arg2Of |
Squatrito,; |
R5845 |
T8571 |
T8572 |
arg1Of |
Squatrito,et |
R5846 |
T8571 |
T8573 |
arg1Of |
Squatrito,al. |
R5847 |
T8571 |
T8574 |
arg1Of |
Squatrito,"," |
R5848 |
T8571 |
T8576 |
arg1Of |
Squatrito,; |
R5849 |
T8575 |
T8574 |
arg2Of |
2010,"," |
R5850 |
T8577 |
T8576 |
arg2Of |
Blough,; |
R5851 |
T8577 |
T8578 |
arg1Of |
Blough,et |
R5852 |
T8577 |
T8579 |
arg1Of |
Blough,al. |
R5853 |
T8577 |
T8580 |
arg1Of |
Blough,"," |
R5854 |
T8581 |
T8580 |
arg2Of |
2011,"," |
R5855 |
T8582 |
T8558 |
arg3Of |
),( |
R5856 |
T8583 |
T8584 |
arg1Of |
Loss,of |
R5857 |
T8583 |
T8587 |
arg1Of |
Loss,confers |
R5858 |
T8586 |
T8584 |
arg2Of |
p53,of |
R5859 |
T8586 |
T8585 |
arg1Of |
p53,functional |
R5860 |
T8587 |
T8589 |
arg1Of |
confers,to |
R5861 |
T8587 |
T8591 |
arg1Of |
confers,in |
R5862 |
T8587 |
T8595 |
arg1Of |
confers,whereas |
R5863 |
T8588 |
T8587 |
arg2Of |
sensitivity,confers |
R5864 |
T8590 |
T8589 |
arg2Of |
TMZ,to |
R5865 |
T8593 |
T8591 |
arg2Of |
cells,in |
R5866 |
T8593 |
T8592 |
arg1Of |
cells,glioma |
R5867 |
T8595 |
T8594 |
arg1Of |
whereas,"," |
R5868 |
T8598 |
T8596 |
arg1Of |
p53,wild |
R5869 |
T8598 |
T8597 |
arg1Of |
p53,type |
R5870 |
T8598 |
T8599 |
arg1Of |
p53,increases |
R5871 |
T8599 |
T8595 |
arg2Of |
increases,whereas |
R5872 |
T8602 |
T8599 |
arg2Of |
resistance,increases |
R5873 |
T8602 |
T8600 |
arg1Of |
resistance,the |
R5874 |
T8602 |
T8601 |
arg1Of |
resistance,TMZ |
R5875 |
T8602 |
T8603 |
arg1Of |
resistance,( |
R5876 |
T8602 |
T8612 |
arg2Of |
resistance,nts re |
R5877 |
T8602 |
T8615 |
arg1Of |
resistance,ti |
R5878 |
T8604 |
T8603 |
arg2Of |
Blough,( |
R5879 |
T8604 |
T8605 |
arg1Of |
Blough,et |
R5880 |
T8604 |
T8606 |
arg1Of |
Blough,al. |
R5881 |
T8604 |
T8607 |
arg1Of |
Blough,"," |
R5882 |
T8608 |
T8607 |
arg2Of |
2011,"," |
R5883 |
T8609 |
T8603 |
arg3Of |
),( |
R5884 |
T8611 |
T8610 |
arg1Of |
53 muta,. p |
R5885 |
T8611 |
T8612 |
arg1Of |
53 muta,nts re |
R5886 |
T8614 |
T8612 |
arg3Of |
e TMZ sensi,nts re |
R5887 |
T8614 |
T8613 |
arg1Of |
e TMZ sensi,duc |
R5888 |
T8616 |
T8615 |
arg2Of |
vity in,ti |
R5889 |
T8616 |
T8617 |
arg1Of |
vity in,g |
R5890 |
T8618 |
T8617 |
arg2Of |
liomas,g |
R5891 |
T8618 |
T8619 |
arg1Of |
liomas,(B |
R5892 |
T8618 |
T8620 |
arg1Of |
liomas,lou |
R5893 |
T8618 |
T8621 |
arg1Of |
liomas,g |
R5894 |
T8622 |
T8621 |
arg2Of |
h et,g |
R5895 |
T8623 |
T8617 |
arg3Of |
a,g |
R5896 |
T8626 |
T8624 |
arg2Of |
expression,Altered |
R5897 |
T8626 |
T8625 |
arg1Of |
expression,WWOX |
R5898 |
T8626 |
T8627 |
arg1Of |
expression,is |
R5899 |
T8626 |
T8628 |
arg2Of |
expression,shown |
R5900 |
T8628 |
T8627 |
arg2Of |
shown,is |
R5901 |
T8628 |
T8629 |
arg1Of |
shown,in |
R5902 |
T8630 |
T8629 |
arg2Of |
GBMs,in |
R5903 |
T8630 |
T8632 |
arg2Of |
GBMs,in |
R5904 |
T8630 |
T8633 |
arg1Of |
GBMs,which |
R5905 |
T8634 |
T8635 |
arg1Of |
downregulation,of |
R5906 |
T8634 |
T8637 |
arg1Of |
downregulation,is |
R5907 |
T8634 |
T8638 |
arg2Of |
downregulation,associated |
R5908 |
T8636 |
T8635 |
arg2Of |
WWOX,of |
R5909 |
T8638 |
T8631 |
arg1Of |
associated,"," |
R5910 |
T8638 |
T8632 |
arg1Of |
associated,in |
R5911 |
T8638 |
T8637 |
arg2Of |
associated,is |
R5912 |
T8638 |
T8639 |
arg1Of |
associated,with |
R5913 |
T8640 |
T8639 |
arg2Of |
loss,with |
R5914 |
T8640 |
T8641 |
arg1Of |
loss,of |
R5915 |
T8642 |
T8643 |
arg1Of |
heterozygosity,and |
R5916 |
T8644 |
T8643 |
arg2Of |
promoter,and |
R5917 |
T8645 |
T8641 |
arg2Of |
methylation,of |
R5918 |
T8645 |
T8642 |
arg1Of |
methylation,heterozygosity |
R5919 |
T8645 |
T8644 |
arg1Of |
methylation,promoter |
R5920 |
T8645 |
T8646 |
arg1Of |
methylation,( |
R5921 |
T8647 |
T8646 |
arg2Of |
Kosla,( |
R5922 |
T8647 |
T8648 |
arg1Of |
Kosla,et |
R5923 |
T8647 |
T8649 |
arg1Of |
Kosla,al. |
R5924 |
T8647 |
T8650 |
arg1Of |
Kosla,"," |
R5925 |
T8651 |
T8650 |
arg2Of |
2011,"," |
R5926 |
T8652 |
T8646 |
arg3Of |
),( |
R5927 |
T8655 |
T8656 |
arg1Of |
we,demonstrated |
R5928 |
T8656 |
T8653 |
arg1Of |
demonstrated,Recently |
R5929 |
T8656 |
T8654 |
arg1Of |
demonstrated,"," |
R5930 |
T8659 |
T8658 |
arg2Of |
WWOX,overexpressed |
R5931 |
T8659 |
T8660 |
arg1Of |
WWOX,induces |
R5932 |
T8659 |
T8670 |
arg1Of |
WWOX,causing |
R5933 |
T8660 |
T8656 |
arg2Of |
induces,demonstrated |
R5934 |
T8660 |
T8657 |
arg1Of |
induces,that |
R5935 |
T8660 |
T8669 |
arg1Of |
induces,by |
R5936 |
T8661 |
T8660 |
arg2Of |
apoptosis,induces |
R5937 |
T8661 |
T8662 |
arg1Of |
apoptosis,of |
R5938 |
T8665 |
T8662 |
arg2Of |
cells,of |
R5939 |
T8665 |
T8663 |
arg1Of |
cells,glioblastoma |
R5940 |
T8665 |
T8664 |
arg1Of |
cells,U373-MG |
R5941 |
T8665 |
T8666 |
arg1Of |
cells,harboring |
R5942 |
T8668 |
T8666 |
arg2Of |
p53,harboring |
R5943 |
T8668 |
T8667 |
arg1Of |
p53,mutant |
R5944 |
T8670 |
T8669 |
arg2Of |
causing,by |
R5945 |
T8670 |
T8675 |
arg1Of |
causing,( |
R5946 |
T8671 |
T8672 |
arg1Of |
hypoploidy,and |
R5947 |
T8672 |
T8670 |
arg2Of |
and,causing |
R5948 |
T8674 |
T8672 |
arg2Of |
fragmentation,and |
R5949 |
T8674 |
T8673 |
arg1Of |
fragmentation,DNA |
R5950 |
T8676 |
T8675 |
arg2Of |
Chiang,( |
R5951 |
T8676 |
T8677 |
arg1Of |
Chiang,et |
R5952 |
T8676 |
T8678 |
arg1Of |
Chiang,al. |
R5953 |
T8676 |
T8679 |
arg1Of |
Chiang,"," |
R5954 |
T8680 |
T8679 |
arg2Of |
2012,"," |
R5955 |
T8681 |
T8675 |
arg3Of |
),( |
R5956 |
T8685 |
T8684 |
arg1Of |
WWOX,ectopic |
R5957 |
T8685 |
T8686 |
arg1Of |
WWOX,has |
R5958 |
T8686 |
T8682 |
arg1Of |
has,However |
R5959 |
T8686 |
T8683 |
arg1Of |
has,"," |
R5960 |
T8688 |
T8686 |
arg2Of |
effect,has |
R5961 |
T8688 |
T8687 |
arg1Of |
effect,no |
R5962 |
T8688 |
T8689 |
arg1Of |
effect,with |
R5963 |
T8690 |
T8689 |
arg2Of |
U87-MG,with |
R5964 |
T8690 |
T8691 |
arg1Of |
U87-MG,expressing |
R5965 |
T8694 |
T8691 |
arg2Of |
p53,expressing |
R5966 |
T8694 |
T8692 |
arg1Of |
p53,wild |
R5967 |
T8694 |
T8693 |
arg1Of |
p53,type |
R5968 |
T8696 |
T8695 |
arg2Of |
TMZ,Unlike |
R5969 |
T8698 |
T8699 |
arg1Of |
WWOX,induces |
R5970 |
T8699 |
T8695 |
arg1Of |
induces,Unlike |
R5971 |
T8699 |
T8697 |
arg1Of |
induces,"," |
R5972 |
T8699 |
T8704 |
arg1Of |
induces,via |
R5973 |
T8700 |
T8699 |
arg2Of |
apoptosis,induces |
R5974 |
T8700 |
T8701 |
arg1Of |
apoptosis,of |
R5975 |
T8703 |
T8701 |
arg2Of |
cells,of |
R5976 |
T8703 |
T8702 |
arg1Of |
cells,U373-MG |
R5977 |
T8706 |
T8707 |
arg1Of |
mitochondria-independent,and |
R5978 |
T8708 |
T8707 |
arg2Of |
caspase-3-independent,and |
R5979 |
T8709 |
T8704 |
arg2Of |
pathway,via |
R5980 |
T8709 |
T8705 |
arg1Of |
pathway,a |
R5981 |
T8709 |
T8706 |
arg1Of |
pathway,mitochondria-independent |
R5982 |
T8709 |
T8708 |
arg1Of |
pathway,caspase-3-independent |
R5983 |
T8709 |
T8710 |
arg1Of |
pathway,( |
R5984 |
T8711 |
T8710 |
arg2Of |
Chiang,( |
R5985 |
T8711 |
T8712 |
arg1Of |
Chiang,et |
R5986 |
T8711 |
T8713 |
arg1Of |
Chiang,al. |
R5987 |
T8711 |
T8714 |
arg1Of |
Chiang,"," |
R5988 |
T8715 |
T8714 |
arg2Of |
2012,"," |
R5989 |
T8716 |
T8710 |
arg3Of |
),( |
R5990 |
T8720 |
T8718 |
arg1Of |
mechanisms,the |
R5991 |
T8720 |
T8719 |
arg1Of |
mechanisms,underlying |
R5992 |
T8720 |
T8721 |
arg1Of |
mechanisms,are |
R5993 |
T8720 |
T8722 |
arg1Of |
mechanisms,unknown |
R5994 |
T8721 |
T8717 |
arg2Of |
are,While |
R5995 |
T8722 |
T8721 |
arg2Of |
unknown,are |
R5996 |
T8725 |
T8717 |
arg1Of |
is,While |
R5997 |
T8725 |
T8723 |
arg1Of |
is,"," |
R5998 |
T8726 |
T8725 |
arg2Of |
reasonable,is |
R5999 |
T8728 |
T8724 |
arg1Of |
assume,it |
R6000 |
T8728 |
T8725 |
arg1Of |
assume,is |
R6001 |
T8728 |
T8726 |
arg1Of |
assume,reasonable |
R6002 |
T8728 |
T8727 |
arg1Of |
assume,to |
R6003 |
T8731 |
T8730 |
arg1Of |
survival,the |
R6004 |
T8731 |
T8732 |
arg1Of |
survival,of |
R6005 |
T8731 |
T8736 |
arg1Of |
survival,depends |
R6006 |
T8735 |
T8732 |
arg2Of |
cells,of |
R6007 |
T8735 |
T8733 |
arg1Of |
cells,human |
R6008 |
T8735 |
T8734 |
arg1Of |
cells,glioblastoma |
R6009 |
T8736 |
T8728 |
arg2Of |
depends,assume |
R6010 |
T8736 |
T8729 |
arg1Of |
depends,that |
R6011 |
T8736 |
T8737 |
arg1Of |
depends,upon |
R6012 |
T8738 |
T8737 |
arg2Of |
interactions,upon |
R6013 |
T8738 |
T8739 |
arg1Of |
interactions,between |
R6014 |
T8741 |
T8739 |
arg2Of |
gain-of-function,between |
R6015 |
T8741 |
T8740 |
arg1Of |
gain-of-function,the |
R6016 |
T8741 |
T8742 |
arg1Of |
gain-of-function,of |
R6017 |
T8744 |
T8743 |
arg1Of |
mutants,p53 |
R6018 |
T8744 |
T8745 |
arg1Of |
mutants,and |
R6019 |
T8745 |
T8742 |
arg2Of |
and,of |
R6020 |
T8746 |
T8745 |
arg2Of |
WWOX,and |
R6021 |
T8748 |
T8747 |
arg2Of |
WWOX,Activated |
R6022 |
T8748 |
T8749 |
arg1Of |
WWOX,binds |
R6023 |
T8749 |
T8756 |
arg1Of |
binds,( |
R6024 |
T8752 |
T8749 |
arg2Of |
p53,binds |
R6025 |
T8752 |
T8750 |
arg1Of |
p53,wild |
R6026 |
T8752 |
T8751 |
arg1Of |
p53,type |
R6027 |
T8752 |
T8753 |
arg1Of |
p53,with |
R6028 |
T8755 |
T8753 |
arg2Of |
phosphorylation,with |
R6029 |
T8755 |
T8754 |
arg1Of |
phosphorylation,Ser46 |
R6030 |
T8757 |
T8756 |
arg2Of |
Chang,( |
R6031 |
T8757 |
T8758 |
arg1Of |
Chang,et |
R6032 |
T8757 |
T8759 |
arg1Of |
Chang,al. |
R6033 |
T8757 |
T8760 |
arg1Of |
Chang,"," |
R6034 |
T8761 |
T8760 |
arg2Of |
2005b,"," |
R6035 |
T8762 |
T8756 |
arg3Of |
),( |
R6036 |
T8764 |
T8763 |
arg1Of |
irradiation,UV |
R6037 |
T8764 |
T8765 |
arg1Of |
irradiation,enhances |
R6038 |
T8768 |
T8765 |
arg2Of |
interactions,enhances |
R6039 |
T8768 |
T8766 |
arg1Of |
interactions,the |
R6040 |
T8768 |
T8767 |
arg1Of |
interactions,binding |
R6041 |
T8771 |
T8769 |
arg2Of |
presence,Despite |
R6042 |
T8771 |
T8770 |
arg1Of |
presence,the |
R6043 |
T8771 |
T8772 |
arg1Of |
presence,of |
R6044 |
T8771 |
T8774 |
arg1Of |
presence,in |
R6045 |
T8773 |
T8772 |
arg2Of |
Ser46,of |
R6046 |
T8775 |
T8774 |
arg2Of |
Δ40p53,in |
R6047 |
T8777 |
T8778 |
arg1Of |
binding,of |
R6048 |
T8777 |
T8783 |
arg1Of |
binding,remains |
R6049 |
T8777 |
T8785 |
arg1Of |
binding,be |
R6050 |
T8777 |
T8786 |
arg2Of |
binding,determined |
R6051 |
T8780 |
T8778 |
arg2Of |
protein,of |
R6052 |
T8780 |
T8779 |
arg1Of |
protein,this |
R6053 |
T8780 |
T8781 |
arg1Of |
protein,with |
R6054 |
T8782 |
T8781 |
arg2Of |
WWOX,with |
R6055 |
T8783 |
T8769 |
arg1Of |
remains,Despite |
R6056 |
T8783 |
T8776 |
arg1Of |
remains,"," |
R6057 |
T8786 |
T8783 |
arg2Of |
determined,remains |
R6058 |
T8786 |
T8784 |
arg1Of |
determined,to |
R6059 |
T8786 |
T8785 |
arg2Of |
determined,be |
R6060 |
T8787 |
T8788 |
arg1Of |
We,postulate |
R6061 |
T8792 |
T8790 |
arg2Of |
cells,in |
R6062 |
T8792 |
T8791 |
arg1Of |
cells,GBM |
R6063 |
T8801 |
T8794 |
arg1Of |
proteins,both |
R6064 |
T8801 |
T8795 |
arg1Of |
proteins,wild |
R6065 |
T8801 |
T8796 |
arg1Of |
proteins,type |
R6066 |
T8801 |
T8797 |
arg1Of |
proteins,p53 |
R6067 |
T8801 |
T8798 |
arg1Of |
proteins,and |
R6068 |
T8801 |
T8799 |
arg1Of |
proteins,ectopic |
R6069 |
T8801 |
T8800 |
arg1Of |
proteins,WWOX |
R6070 |
T8801 |
T8802 |
arg1Of |
proteins,appear |
R6071 |
T8801 |
T8804 |
arg1Of |
proteins,have |
R6072 |
T8801 |
T8810 |
arg1Of |
proteins,nullifying |
R6073 |
T8802 |
T8788 |
arg2Of |
appear,postulate |
R6074 |
T8802 |
T8789 |
arg1Of |
appear,that |
R6075 |
T8802 |
T8790 |
arg1Of |
appear,in |
R6076 |
T8802 |
T8793 |
arg1Of |
appear,"," |
R6077 |
T8804 |
T8802 |
arg2Of |
have,appear |
R6078 |
T8804 |
T8803 |
arg1Of |
have,to |
R6079 |
T8804 |
T8808 |
arg1Of |
have,"," |
R6080 |
T8807 |
T8804 |
arg2Of |
antagonism,have |
R6081 |
T8807 |
T8805 |
arg1Of |
antagonism,a |
R6082 |
T8807 |
T8806 |
arg1Of |
antagonism,functional |
R6083 |
T8810 |
T8804 |
arg3Of |
nullifying,have |
R6084 |
T8810 |
T8809 |
arg1Of |
nullifying,thereby |
R6085 |
T8812 |
T8811 |
arg1Of |
other’s,each |
R6086 |
T8812 |
T8813 |
arg1Of |
other’s,function |
R6087 |
T8812 |
T8815 |
arg1Of |
other’s,inducing |
R6088 |
T8813 |
T8810 |
arg2Of |
function,nullifying |
R6089 |
T8813 |
T8814 |
arg1Of |
function,in |
R6090 |
T8815 |
T8814 |
arg2Of |
inducing,in |
R6091 |
T8816 |
T8815 |
arg2Of |
apoptosis,inducing |
R6092 |
T8816 |
T8817 |
arg1Of |
apoptosis,( |
R6093 |
T8818 |
T8817 |
arg2Of |
Figure,( |
R6094 |
T8818 |
T8819 |
arg1Of |
Figure,2 |
R6095 |
T8820 |
T8817 |
arg3Of |
),( |
R6096 |
T8823 |
T8821 |
arg1Of |
proteins,Mutant |
R6097 |
T8823 |
T8822 |
arg1Of |
proteins,p53 |
R6098 |
T8823 |
T8824 |
arg1Of |
proteins,can |
R6099 |
T8823 |
T8826 |
arg1Of |
proteins,bind |
R6100 |
T8826 |
T8824 |
arg2Of |
bind,can |
R6101 |
T8826 |
T8825 |
arg1Of |
bind,not |
R6102 |
T8826 |
T8829 |
arg1Of |
bind,in |
R6103 |
T8826 |
T8833 |
arg1Of |
bind,and |
R6104 |
T8828 |
T8826 |
arg2Of |
WWOX,bind |
R6105 |
T8828 |
T8827 |
arg1Of |
WWOX,ectopic |
R6106 |
T8831 |
T8829 |
arg2Of |
cells,in |
R6107 |
T8831 |
T8830 |
arg1Of |
cells,GBM |
R6108 |
T8833 |
T8832 |
arg1Of |
and,"," |
R6109 |
T8834 |
T8835 |
arg1Of |
WWOX,is |
R6110 |
T8834 |
T8836 |
arg1Of |
WWOX,able |
R6111 |
T8834 |
T8838 |
arg1Of |
WWOX,induce |
R6112 |
T8835 |
T8833 |
arg2Of |
is,and |
R6113 |
T8836 |
T8835 |
arg2Of |
able,is |
R6114 |
T8838 |
T8836 |
arg2Of |
induce,able |
R6115 |
T8838 |
T8837 |
arg1Of |
induce,to |
R6116 |
T8839 |
T8838 |
arg2Of |
apoptosis,induce |
R6117 |
T8841 |
T8842 |
arg1Of |
WWOX,causes |
R6118 |
T8842 |
T8840 |
arg1Of |
causes,Whether |
R6119 |
T8842 |
T8844 |
arg1Of |
causes,in |
R6120 |
T8842 |
T8849 |
arg1Of |
causes,is |
R6121 |
T8842 |
T8850 |
arg1Of |
causes,unknown |
R6122 |
T8842 |
T8852 |
arg1Of |
causes,remains |
R6123 |
T8842 |
T8854 |
arg1Of |
causes,be |
R6124 |
T8842 |
T8855 |
arg2Of |
causes,established |
R6125 |
T8843 |
T8842 |
arg2Of |
apoptosis,causes |
R6126 |
T8848 |
T8844 |
arg2Of |
isoforms,in |
R6127 |
T8848 |
T8845 |
arg1Of |
isoforms,GBM |
R6128 |
T8848 |
T8846 |
arg1Of |
isoforms,expressing |
R6129 |
T8848 |
T8847 |
arg1Of |
isoforms,p53 |
R6130 |
T8849 |
T8851 |
arg1Of |
is,and |
R6131 |
T8850 |
T8849 |
arg2Of |
unknown,is |
R6132 |
T8852 |
T8851 |
arg2Of |
remains,and |
R6133 |
T8855 |
T8852 |
arg2Of |
established,remains |
R6134 |
T8855 |
T8853 |
arg1Of |
established,to |
R6135 |
T8855 |
T8854 |
arg2Of |
established,be |