| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T952 |
13-19 |
JJ |
denotes |
Cystic |
| T953 |
20-28 |
NN |
denotes |
fibrosis |
| T954 |
29-31 |
VB |
denotes |
is |
| T955 |
32-34 |
DT |
denotes |
an |
| T956 |
35-44 |
JJ |
denotes |
autosomal |
| T957 |
45-54 |
JJ |
denotes |
recessive |
| T958 |
55-62 |
NN |
denotes |
disease |
| T959 |
63-69 |
VB |
denotes |
caused |
| T960 |
70-72 |
IN |
denotes |
by |
| T961 |
73-82 |
NN |
denotes |
mutations |
| T962 |
83-85 |
IN |
denotes |
in |
| T963 |
86-89 |
DT |
denotes |
the |
| T964 |
90-96 |
JJ |
denotes |
cystic |
| T965 |
97-105 |
NN |
denotes |
fibrosis |
| T966 |
106-119 |
JJ |
denotes |
transmembrane |
| T967 |
120-131 |
NN |
denotes |
conductance |
| T968 |
132-141 |
NN |
denotes |
regulator |
| T969 |
142-143 |
-LRB- |
denotes |
( |
| T970 |
143-147 |
NN |
denotes |
CFTR |
| T971 |
147-148 |
-RRB- |
denotes |
) |
| T972 |
148-149 |
-COMMA- |
denotes |
, |
| T973 |
150-155 |
WDT |
denotes |
which |
| T974 |
156-165 |
VB |
denotes |
functions |
| T975 |
166-168 |
IN |
denotes |
as |
| T976 |
169-170 |
DT |
denotes |
a |
| T977 |
171-179 |
NN |
denotes |
chloride |
| T978 |
180-183 |
NN |
denotes |
ion |
| T979 |
184-191 |
NN |
denotes |
channel |
| T980 |
193-195 |
NN |
denotes |
CF |
| T981 |
196-203 |
VB |
denotes |
remains |
| T982 |
204-207 |
CD |
denotes |
one |
| T983 |
208-210 |
IN |
denotes |
of |
| T984 |
211-214 |
DT |
denotes |
the |
| T985 |
215-219 |
RB |
denotes |
most |
| T986 |
220-226 |
JJ |
denotes |
common |
| T987 |
227-233 |
JJ |
denotes |
lethal |
| T988 |
234-241 |
JJ |
denotes |
genetic |
| T989 |
242-250 |
NN |
denotes |
diseases |
| T990 |
251-253 |
IN |
denotes |
in |
| T991 |
254-265 |
NN |
denotes |
populations |
| T992 |
266-268 |
IN |
denotes |
of |
| T993 |
269-277 |
JJ |
denotes |
European |
| T994 |
278-285 |
NN |
denotes |
descent |
| T995 |
286-290 |
IN |
denotes |
with |
| T996 |
291-294 |
DT |
denotes |
the |
| T997 |
295-302 |
JJ |
denotes |
current |
| T998 |
303-310 |
JJ |
denotes |
average |
| T999 |
311-319 |
NN |
denotes |
lifespan |
| T1000 |
320-322 |
IN |
denotes |
of |
| T1001 |
323-325 |
NN |
denotes |
CF |
| T1002 |
326-334 |
NN |
denotes |
patients |
| T1003 |
335-348 |
RB |
denotes |
approximately |
| T1004 |
349-351 |
CD |
denotes |
40 |
| T1005 |
352-357 |
NN |
denotes |
years |
| T1006 |
358-360 |
IN |
denotes |
of |
| T1007 |
361-364 |
NN |
denotes |
age |
| T1008 |
365-366 |
-LRB- |
denotes |
[ |
| T1009 |
366-367 |
CD |
denotes |
1 |
| T1010 |
367-368 |
-RRB- |
denotes |
] |
| T1011 |
368-369 |
-COMMA- |
denotes |
, |
| T1012 |
370-371 |
-LRB- |
denotes |
[ |
| T1013 |
371-372 |
CD |
denotes |
2 |
| T1014 |
372-373 |
-RRB- |
denotes |
] |
| T1015 |
375-384 |
JJ |
denotes |
Recurrent |
| T1016 |
385-397 |
JJ |
denotes |
inflammatory |
| T1017 |
398-407 |
JJ |
denotes |
pulmonary |
| T1018 |
408-420 |
NN |
denotes |
exacerbation |
| T1019 |
421-423 |
VB |
denotes |
is |
| T1020 |
424-427 |
DT |
denotes |
the |
| T1021 |
428-435 |
JJ |
denotes |
primary |
| T1022 |
436-441 |
NN |
denotes |
cause |
| T1023 |
442-444 |
IN |
denotes |
of |
| T1024 |
445-449 |
NN |
denotes |
lung |
| T1025 |
450-457 |
NN |
denotes |
disease |
| T1026 |
458-469 |
NN |
denotes |
progression |
| T1027 |
470-473 |
CC |
denotes |
and |
| T1028 |
474-484 |
RB |
denotes |
ultimately |
| T1029 |
484-485 |
-COMMA- |
denotes |
, |
| T1030 |
486-491 |
NN |
denotes |
death |
| T1031 |
492-494 |
IN |
denotes |
in |
| T1032 |
495-497 |
NN |
denotes |
CF |
| T1033 |
499-509 |
VB |
denotes |
Controlled |
| T1034 |
510-522 |
NN |
denotes |
inflammation |
| T1035 |
523-525 |
VB |
denotes |
is |
| T1036 |
526-535 |
JJ |
denotes |
important |
| T1037 |
536-539 |
IN |
denotes |
for |
| T1038 |
540-548 |
VB |
denotes |
fighting |
| T1039 |
549-558 |
NN |
denotes |
infection |
| T1040 |
558-559 |
-COMMA- |
denotes |
, |
| T1041 |
560-563 |
CC |
denotes |
but |
| T1042 |
564-566 |
IN |
denotes |
in |
| T1043 |
567-573 |
NN |
denotes |
excess |
| T1044 |
573-574 |
-COMMA- |
denotes |
, |
| T1045 |
575-577 |
PRP |
denotes |
it |
| T1046 |
578-585 |
VB |
denotes |
becomes |
| T1047 |
586-597 |
JJ |
denotes |
destructive |
| T1048 |
598-600 |
TO |
denotes |
to |
| T1049 |
601-605 |
NN |
denotes |
host |
| T1050 |
606-611 |
NN |
denotes |
cells |
| T1051 |
612-615 |
CC |
denotes |
and |
| T1052 |
616-618 |
TO |
denotes |
to |
| T1053 |
619-622 |
DT |
denotes |
the |
| T1054 |
623-635 |
NN |
denotes |
architecture |
| T1055 |
636-638 |
IN |
denotes |
of |
| T1056 |
639-642 |
DT |
denotes |
the |
| T1057 |
643-648 |
NN |
denotes |
lungs |
| T1058 |
649-650 |
-LRB- |
denotes |
[ |
| T1059 |
650-651 |
CD |
denotes |
2 |
| T1060 |
651-652 |
-RRB- |
denotes |
] |
| T1061 |
652-653 |
-COMMA- |
denotes |
, |
| T1062 |
654-655 |
-LRB- |
denotes |
[ |
| T1063 |
655-656 |
CD |
denotes |
3 |
| T1064 |
656-657 |
-RRB- |
denotes |
] |
| T1065 |
659-661 |
IN |
denotes |
In |
| T1066 |
662-664 |
NN |
denotes |
CF |
| T1067 |
664-665 |
-COMMA- |
denotes |
, |
| T1068 |
666-672 |
NN |
denotes |
airway |
| T1069 |
673-683 |
JJ |
denotes |
epithelial |
| T1070 |
684-689 |
NN |
denotes |
cells |
| T1071 |
690-694 |
VB |
denotes |
have |
| T1072 |
695-699 |
VB |
denotes |
been |
| T1073 |
700-705 |
VB |
denotes |
shown |
| T1074 |
706-708 |
TO |
denotes |
to |
| T1075 |
709-716 |
VB |
denotes |
produce |
| T1076 |
717-719 |
DT |
denotes |
an |
| T1077 |
720-731 |
JJ |
denotes |
exaggerated |
| T1078 |
732-748 |
JJ |
denotes |
pro-inflammatory |
| T1079 |
749-757 |
NN |
denotes |
cytokine |
| T1080 |
758-766 |
NN |
denotes |
response |
| T1081 |
767-769 |
TO |
denotes |
to |
| T1082 |
770-781 |
NN |
denotes |
stimulation |
| T1083 |
782-783 |
-LRB- |
denotes |
[ |
| T1084 |
783-784 |
CD |
denotes |
4 |
| T1085 |
784-785 |
-RRB- |
denotes |
] |
| T1086 |
785-786 |
-COMMA- |
denotes |
, |
| T1087 |
787-788 |
-LRB- |
denotes |
[ |
| T1088 |
788-789 |
CD |
denotes |
5 |
| T1089 |
789-790 |
-RRB- |
denotes |
] |
| T1090 |
792-794 |
PRP |
denotes |
It |
| T1091 |
795-797 |
VB |
denotes |
is |
| T1092 |
798-805 |
JJ |
denotes |
unclear |
| T1093 |
806-813 |
IN |
denotes |
whether |
| T1094 |
814-818 |
DT |
denotes |
this |
| T1095 |
819-829 |
VB |
denotes |
heightened |
| T1096 |
830-842 |
JJ |
denotes |
inflammatory |
| T1097 |
843-851 |
NN |
denotes |
response |
| T1098 |
852-854 |
VB |
denotes |
is |
| T1099 |
855-864 |
JJ |
denotes |
intrinsic |
| T1100 |
865-867 |
TO |
denotes |
to |
| T1101 |
868-873 |
NN |
denotes |
cells |
| T1102 |
874-881 |
VB |
denotes |
lacking |
| T1103 |
882-886 |
NN |
denotes |
CFTR |
| T1104 |
887-889 |
CC |
denotes |
or |
| T1105 |
890-897 |
IN |
denotes |
whether |
| T1106 |
898-900 |
PRP |
denotes |
it |
| T1107 |
901-903 |
VB |
denotes |
is |
| T1108 |
904-905 |
DT |
denotes |
a |
| T1109 |
906-912 |
NN |
denotes |
result |
| T1110 |
913-915 |
IN |
denotes |
of |
| T1111 |
916-923 |
JJ |
denotes |
chronic |
| T1112 |
924-937 |
JJ |
denotes |
polymicrobial |
| T1113 |
938-947 |
NN |
denotes |
infection |
| T1114 |
948-949 |
-LRB- |
denotes |
[ |
| T1115 |
949-950 |
CD |
denotes |
6 |
| T1116 |
950-951 |
-RRB- |
denotes |
] |
| T1117 |
951-952 |
-COMMA- |
denotes |
, |
| T1118 |
953-954 |
-LRB- |
denotes |
[ |
| T1119 |
954-955 |
CD |
denotes |
7 |
| T1120 |
955-956 |
-RRB- |
denotes |
] |
| T1121 |
958-968 |
RB |
denotes |
Regardless |
| T1122 |
969-971 |
IN |
denotes |
of |
| T1123 |
972-976 |
DT |
denotes |
this |
| T1124 |
977-988 |
NN |
denotes |
controversy |
| T1125 |
988-989 |
-COMMA- |
denotes |
, |
| T1126 |
990-1001 |
VB |
denotes |
identifying |
| T1127 |
1002-1005 |
CC |
denotes |
and |
| T1128 |
1006-1015 |
VB |
denotes |
targeting |
| T1129 |
1016-1024 |
JJ |
denotes |
relevant |
| T1130 |
1025-1037 |
JJ |
denotes |
inflammatory |
| T1131 |
1038-1047 |
NN |
denotes |
mediators |
| T1132 |
1048-1050 |
VB |
denotes |
is |
| T1133 |
1051-1052 |
DT |
denotes |
a |
| T1134 |
1053-1061 |
JJ |
denotes |
critical |
| T1135 |
1062-1066 |
NN |
denotes |
step |
| T1136 |
1067-1069 |
IN |
denotes |
in |
| T1137 |
1070-1080 |
VB |
denotes |
developing |
| T1138 |
1081-1085 |
RB |
denotes |
more |
| T1139 |
1086-1094 |
JJ |
denotes |
specific |
| T1140 |
1095-1106 |
JJ |
denotes |
therapeutic |
| T1141 |
1107-1117 |
NN |
denotes |
approaches |
| T1142 |
1118-1120 |
TO |
denotes |
to |
| T1143 |
1121-1128 |
VB |
denotes |
control |
| T1144 |
1129-1141 |
NN |
denotes |
inflammation |
| T1145 |
1142-1145 |
CC |
denotes |
and |
| T1146 |
1146-1153 |
VB |
denotes |
improve |
| T1147 |
1154-1160 |
NN |
denotes |
health |
| T1148 |
1161-1169 |
NN |
denotes |
outcomes |
| T1149 |
1170-1172 |
IN |
denotes |
in |
| T1150 |
1173-1175 |
NN |
denotes |
CF |
| T1151 |
1176-1177 |
-LRB- |
denotes |
[ |
| T1152 |
1177-1178 |
CD |
denotes |
8 |
| T1153 |
1178-1179 |
-RRB- |
denotes |
] |
| T1154 |
1181-1194 |
NN |
denotes |
Interleukin-1 |
| T1155 |
1195-1199 |
NN |
denotes |
beta |
| T1156 |
1200-1201 |
-LRB- |
denotes |
( |
| T1157 |
1201-1206 |
NN |
denotes |
IL-1β |
| T1158 |
1206-1207 |
-RRB- |
denotes |
) |
| T1159 |
1208-1210 |
VB |
denotes |
is |
| T1160 |
1211-1212 |
DT |
denotes |
a |
| T1161 |
1213-1218 |
JJ |
denotes |
major |
| T1162 |
1219-1231 |
JJ |
denotes |
inflammatory |
| T1163 |
1232-1240 |
NN |
denotes |
mediator |
| T1164 |
1242-1245 |
PRP-DOLLAR- |
denotes |
Its |
| T1165 |
1246-1259 |
JJ |
denotes |
physiological |
| T1166 |
1260-1267 |
NN |
denotes |
effects |
| T1167 |
1268-1271 |
VB |
denotes |
are |
| T1168 |
1272-1279 |
JJ |
denotes |
diverse |
| T1169 |
1280-1283 |
CC |
denotes |
and |
| T1170 |
1284-1295 |
RB |
denotes |
potentially |
| T1171 |
1296-1305 |
JJ |
denotes |
important |
| T1172 |
1306-1308 |
TO |
denotes |
to |
| T1173 |
1309-1312 |
DT |
denotes |
the |
| T1174 |
1313-1325 |
NN |
denotes |
pathogenesis |
| T1175 |
1326-1328 |
IN |
denotes |
of |
| T1176 |
1329-1333 |
NN |
denotes |
lung |
| T1177 |
1334-1347 |
NN |
denotes |
exacerbations |
| T1178 |
1348-1350 |
IN |
denotes |
in |
| T1179 |
1351-1353 |
NN |
denotes |
CF |
| T1180 |
1353-1354 |
-COMMA- |
denotes |
, |
| T1181 |
1355-1364 |
VB |
denotes |
including |
| T1182 |
1365-1368 |
DT |
denotes |
the |
| T1183 |
1369-1379 |
NN |
denotes |
generation |
| T1184 |
1380-1382 |
IN |
denotes |
of |
| T1185 |
1383-1388 |
NN |
denotes |
fever |
| T1186 |
1388-1389 |
-COMMA- |
denotes |
, |
| T1187 |
1390-1393 |
DT |
denotes |
the |
| T1188 |
1394-1405 |
NN |
denotes |
recruitment |
| T1189 |
1406-1408 |
IN |
denotes |
of |
| T1190 |
1409-1421 |
JJ |
denotes |
inflammatory |
| T1191 |
1422-1430 |
NN |
denotes |
effector |
| T1192 |
1431-1436 |
NN |
denotes |
cells |
| T1193 |
1436-1437 |
-COMMA- |
denotes |
, |
| T1194 |
1438-1441 |
DT |
denotes |
the |
| T1195 |
1442-1451 |
NN |
denotes |
induction |
| T1196 |
1452-1454 |
IN |
denotes |
of |
| T1197 |
1455-1460 |
JJ |
denotes |
other |
| T1198 |
1461-1477 |
JJ |
denotes |
pro-inflammatory |
| T1199 |
1478-1487 |
NN |
denotes |
cytokines |
| T1200 |
1488-1492 |
JJ |
denotes |
such |
| T1201 |
1493-1495 |
IN |
denotes |
as |
| T1202 |
1496-1500 |
NN |
denotes |
IL-6 |
| T1203 |
1501-1504 |
CC |
denotes |
and |
| T1204 |
1505-1509 |
NN |
denotes |
IL-8 |
| T1205 |
1509-1510 |
-COMMA- |
denotes |
, |
| T1206 |
1511-1514 |
CC |
denotes |
and |
| T1207 |
1515-1518 |
DT |
denotes |
the |
| T1208 |
1519-1526 |
NN |
denotes |
shaping |
| T1209 |
1527-1529 |
IN |
denotes |
of |
| T1210 |
1530-1531 |
NN |
denotes |
T |
| T1211 |
1532-1536 |
NN |
denotes |
cell |
| T1212 |
1537-1546 |
NN |
denotes |
responses |
| T1213 |
1547-1548 |
-LRB- |
denotes |
[ |
| T1214 |
1548-1549 |
CD |
denotes |
9 |
| T1215 |
1549-1550 |
-RRB- |
denotes |
] |
| T1216 |
1550-1551 |
-COMMA- |
denotes |
, |
| T1217 |
1552-1553 |
-LRB- |
denotes |
[ |
| T1218 |
1553-1555 |
CD |
denotes |
10 |
| T1219 |
1555-1556 |
-RRB- |
denotes |
] |
| T1220 |
1558-1567 |
VB |
denotes |
Following |
| T1221 |
1568-1578 |
NN |
denotes |
initiation |
| T1222 |
1579-1581 |
IN |
denotes |
of |
| T1223 |
1582-1585 |
DT |
denotes |
the |
| T1224 |
1586-1591 |
NN |
denotes |
NF-κB |
| T1225 |
1592-1601 |
NN |
denotes |
signaling |
| T1226 |
1602-1609 |
NN |
denotes |
cascade |
| T1227 |
1609-1610 |
-COMMA- |
denotes |
, |
| T1228 |
1611-1616 |
NN |
denotes |
IL-1β |
| T1229 |
1617-1619 |
VB |
denotes |
is |
| T1230 |
1620-1628 |
VB |
denotes |
produced |
| T1231 |
1629-1631 |
IN |
denotes |
in |
| T1232 |
1632-1635 |
DT |
denotes |
the |
| T1233 |
1636-1643 |
NN |
denotes |
cytosol |
| T1234 |
1644-1646 |
IN |
denotes |
as |
| T1235 |
1647-1648 |
DT |
denotes |
a |
| T1236 |
1649-1661 |
RB |
denotes |
biologically |
| T1237 |
1662-1670 |
JJ |
denotes |
inactive |
| T1238 |
1671-1682 |
JJ |
denotes |
full-length |
| T1239 |
1683-1692 |
NN |
denotes |
pro-IL-1β |
| T1240 |
1694-1703 |
NN |
denotes |
Pro-IL-1β |
| T1241 |
1704-1706 |
VB |
denotes |
is |
| T1242 |
1707-1719 |
RB |
denotes |
subsequently |
| T1243 |
1720-1729 |
VB |
denotes |
converted |
| T1244 |
1730-1734 |
IN |
denotes |
into |
| T1245 |
1735-1738 |
PRP-DOLLAR- |
denotes |
its |
| T1246 |
1739-1745 |
JJ |
denotes |
active |
| T1247 |
1746-1750 |
NN |
denotes |
form |
| T1248 |
1751-1753 |
IN |
denotes |
by |
| T1249 |
1754-1763 |
JJ |
denotes |
cytosolic |
| T1250 |
1764-1771 |
NN |
denotes |
protein |
| T1251 |
1772-1781 |
NN |
denotes |
complexes |
| T1252 |
1782-1788 |
VB |
denotes |
termed |
| T1253 |
1789-1805 |
NN |
denotes |
“inflammasomes.” |
| T1254 |
1806-1819 |
NN |
denotes |
Inflammasomes |
| T1255 |
1820-1828 |
NN |
denotes |
assemble |
| T1256 |
1829-1831 |
IN |
denotes |
in |
| T1257 |
1832-1840 |
NN |
denotes |
response |
| T1258 |
1841-1843 |
TO |
denotes |
to |
| T1259 |
1844-1851 |
JJ |
denotes |
certain |
| T1260 |
1852-1860 |
JJ |
denotes |
cellular |
| T1261 |
1861-1867 |
NN |
denotes |
danger |
| T1262 |
1868-1875 |
NN |
denotes |
signals |
| T1263 |
1876-1879 |
CC |
denotes |
and |
| T1264 |
1880-1887 |
VB |
denotes |
mediate |
| T1265 |
1888-1891 |
DT |
denotes |
the |
| T1266 |
1892-1907 |
NN |
denotes |
auto-activation |
| T1267 |
1908-1910 |
IN |
denotes |
of |
| T1268 |
1911-1920 |
NN |
denotes |
caspase-1 |
| T1269 |
1921-1922 |
-LRB- |
denotes |
[ |
| T1270 |
1922-1923 |
CD |
denotes |
9 |
| T1271 |
1923-1924 |
-RRB- |
denotes |
] |
| T1272 |
1924-1925 |
-COMMA- |
denotes |
, |
| T1273 |
1926-1927 |
-LRB- |
denotes |
[ |
| T1274 |
1927-1929 |
CD |
denotes |
11 |
| T1275 |
1929-1930 |
-RRB- |
denotes |
] |
| T1276 |
1930-1931 |
-COMMA- |
denotes |
, |
| T1277 |
1932-1937 |
WDT |
denotes |
which |
| T1278 |
1938-1945 |
VB |
denotes |
cleaves |
| T1279 |
1946-1955 |
NN |
denotes |
pro-IL-1β |
| T1280 |
1956-1959 |
CC |
denotes |
and |
| T1281 |
1960-1969 |
NN |
denotes |
pro-IL-18 |
| T1282 |
1970-1974 |
IN |
denotes |
into |
| T1283 |
1975-1980 |
PRP-DOLLAR- |
denotes |
their |
| T1284 |
1981-1993 |
RB |
denotes |
biologically |
| T1285 |
1994-2000 |
JJ |
denotes |
active |
| T1286 |
2001-2006 |
NN |
denotes |
forms |
| T1287 |
2007-2010 |
IN |
denotes |
for |
| T1288 |
2011-2020 |
NN |
denotes |
secretion |
| T1289 |
2022-2026 |
CD |
denotes |
Four |
| T1290 |
2027-2035 |
JJ |
denotes |
distinct |
| T1291 |
2036-2049 |
NN |
denotes |
inflammasomes |
| T1292 |
2050-2054 |
VB |
denotes |
have |
| T1293 |
2055-2059 |
VB |
denotes |
been |
| T1294 |
2060-2070 |
VB |
denotes |
recognized |
| T1295 |
2072-2077 |
DT |
denotes |
These |
| T1296 |
2078-2081 |
VB |
denotes |
are |
| T1297 |
2082-2085 |
DT |
denotes |
the |
| T1298 |
2086-2091 |
NN |
denotes |
NLRP1 |
| T1299 |
2092-2093 |
-LRB- |
denotes |
[ |
| T1300 |
2093-2095 |
CD |
denotes |
12 |
| T1301 |
2095-2096 |
-RRB- |
denotes |
] |
| T1302 |
2096-2097 |
-COMMA- |
denotes |
, |
| T1303 |
2098-2103 |
NN |
denotes |
NLRP3 |
| T1304 |
2104-2105 |
-LRB- |
denotes |
[ |
| T1305 |
2105-2107 |
CD |
denotes |
13 |
| T1306 |
2107-2108 |
-RRB- |
denotes |
] |
| T1307 |
2108-2109 |
-COMMA- |
denotes |
, |
| T1308 |
2110-2111 |
-LRB- |
denotes |
[ |
| T1309 |
2111-2113 |
CD |
denotes |
14 |
| T1310 |
2113-2114 |
-RRB- |
denotes |
] |
| T1311 |
2114-2115 |
-COMMA- |
denotes |
, |
| T1312 |
2116-2121 |
NN |
denotes |
NLRC4 |
| T1313 |
2122-2123 |
-LRB- |
denotes |
[ |
| T1314 |
2123-2125 |
CD |
denotes |
15 |
| T1315 |
2125-2126 |
-RRB- |
denotes |
] |
| T1316 |
2126-2127 |
-COMMA- |
denotes |
, |
| T1317 |
2128-2129 |
-LRB- |
denotes |
[ |
| T1318 |
2129-2131 |
CD |
denotes |
16 |
| T1319 |
2131-2132 |
-RRB- |
denotes |
] |
| T1320 |
2132-2133 |
-COMMA- |
denotes |
, |
| T1321 |
2134-2137 |
CC |
denotes |
and |
| T1322 |
2138-2142 |
NN |
denotes |
AIM2 |
| T1323 |
2143-2156 |
NN |
denotes |
inflammasomes |
| T1324 |
2157-2158 |
-LRB- |
denotes |
[ |
| T1325 |
2158-2160 |
CD |
denotes |
17 |
| T1326 |
2160-2161 |
-RRB- |
denotes |
] |
| T1327 |
2161-2162 |
-COMMA- |
denotes |
, |
| T1328 |
2163-2164 |
-LRB- |
denotes |
[ |
| T1329 |
2164-2166 |
CD |
denotes |
18 |
| T1330 |
2166-2167 |
-RRB- |
denotes |
] |
| T1331 |
2167-2168 |
-COMMA- |
denotes |
, |
| T1332 |
2169-2174 |
WDT |
denotes |
which |
| T1333 |
2175-2182 |
VB |
denotes |
respond |
| T1334 |
2183-2185 |
TO |
denotes |
to |
| T1335 |
2186-2187 |
DT |
denotes |
a |
| T1336 |
2188-2195 |
NN |
denotes |
variety |
| T1337 |
2196-2198 |
IN |
denotes |
of |
| T1338 |
2199-2208 |
JJ |
denotes |
different |
| T1339 |
2209-2218 |
JJ |
denotes |
microbial |
| T1340 |
2219-2229 |
NN |
denotes |
signatures |
| T1341 |
2230-2233 |
CC |
denotes |
and |
| T1342 |
2234-2240 |
NN |
denotes |
danger |
| T1343 |
2241-2248 |
NN |
denotes |
signals |
| T1344 |
2249-2250 |
-LRB- |
denotes |
[ |
| T1345 |
2250-2252 |
CD |
denotes |
11 |
| T1346 |
2252-2253 |
-RRB- |
denotes |
] |
| T1347 |
2255-2257 |
NNP |
denotes |
P. |
| T1348 |
2258-2268 |
NNP |
denotes |
aeruginosa |
| T1349 |
2268-2269 |
-COMMA- |
denotes |
, |
| T1350 |
2270-2273 |
CD |
denotes |
one |
| T1351 |
2274-2276 |
IN |
denotes |
of |
| T1352 |
2277-2280 |
DT |
denotes |
the |
| T1353 |
2281-2285 |
RB |
denotes |
most |
| T1354 |
2286-2292 |
JJ |
denotes |
common |
| T1355 |
2293-2296 |
CC |
denotes |
and |
| T1356 |
2297-2307 |
RB |
denotes |
clinically |
| T1357 |
2308-2316 |
JJ |
denotes |
relevant |
| T1358 |
2317-2326 |
NN |
denotes |
pathogens |
| T1359 |
2327-2332 |
IN |
denotes |
among |
| T1360 |
2333-2335 |
NN |
denotes |
CF |
| T1361 |
2336-2344 |
NN |
denotes |
patients |
| T1362 |
2344-2345 |
-COMMA- |
denotes |
, |
| T1363 |
2346-2355 |
VB |
denotes |
activates |
| T1364 |
2356-2359 |
DT |
denotes |
the |
| T1365 |
2360-2365 |
NN |
denotes |
NLRC4 |
| T1366 |
2366-2378 |
NN |
denotes |
inflammasome |
| T1367 |
2379-2380 |
-LRB- |
denotes |
[ |
| T1368 |
2380-2382 |
CD |
denotes |
19 |
| T1369 |
2382-2383 |
-RRB- |
denotes |
] |
| T1370 |
2383-2384 |
-COMMA- |
denotes |
, |
| T1371 |
2385-2386 |
-LRB- |
denotes |
[ |
| T1372 |
2386-2388 |
CD |
denotes |
20 |
| T1373 |
2388-2389 |
-RRB- |
denotes |
] |
| T1374 |
2391-2400 |
NN |
denotes |
Infection |
| T1375 |
2401-2405 |
IN |
denotes |
with |
| T1376 |
2406-2408 |
NNP |
denotes |
P. |
| T1377 |
2409-2419 |
NN |
denotes |
aeruginosa |
| T1378 |
2420-2428 |
VB |
denotes |
triggers |
| T1379 |
2429-2431 |
DT |
denotes |
an |
| T1380 |
2432-2440 |
NN |
denotes |
increase |
| T1381 |
2441-2443 |
IN |
denotes |
in |
| T1382 |
2444-2450 |
NN |
denotes |
levels |
| T1383 |
2451-2453 |
IN |
denotes |
of |
| T1384 |
2454-2459 |
NN |
denotes |
IL-1β |
| T1385 |
2459-2460 |
-COMMA- |
denotes |
, |
| T1386 |
2461-2465 |
NN |
denotes |
IL-6 |
| T1387 |
2465-2466 |
-COMMA- |
denotes |
, |
| T1388 |
2467-2470 |
CC |
denotes |
and |
| T1389 |
2471-2475 |
NN |
denotes |
IL-8 |
| T1390 |
2476-2478 |
IN |
denotes |
in |
| T1391 |
2479-2494 |
JJ |
denotes |
bronchoalveolar |
| T1392 |
2495-2501 |
NN |
denotes |
lavage |
| T1393 |
2502-2507 |
NN |
denotes |
fluid |
| T1394 |
2508-2509 |
-LRB- |
denotes |
( |
| T1395 |
2509-2513 |
NN |
denotes |
BALF |
| T1396 |
2513-2514 |
-RRB- |
denotes |
) |
| T1397 |
2515-2519 |
IN |
denotes |
from |
| T1398 |
2520-2528 |
NN |
denotes |
patients |
| T1399 |
2529-2533 |
IN |
denotes |
with |
| T1400 |
2534-2536 |
NN |
denotes |
CF |
| T1401 |
2537-2538 |
-LRB- |
denotes |
[ |
| T1402 |
2538-2540 |
CD |
denotes |
21 |
| T1403 |
2540-2541 |
-RRB- |
denotes |
] |
| T1404 |
2543-2555 |
JJ |
denotes |
Inflammasome |
| T1405 |
2556-2565 |
NN |
denotes |
responses |
| T1406 |
2566-2572 |
VB |
denotes |
depend |
| T1407 |
2573-2575 |
IN |
denotes |
on |
| T1408 |
2576-2581 |
NN |
denotes |
NF-κB |
| T1409 |
2582-2591 |
NN |
denotes |
signaling |
| T1410 |
2591-2592 |
-COMMA- |
denotes |
, |
| T1411 |
2593-2598 |
WRB |
denotes |
where |
| T1412 |
2599-2604 |
NN |
denotes |
NF-κB |
| T1413 |
2605-2607 |
VB |
denotes |
is |
| T1414 |
2608-2617 |
JJ |
denotes |
important |
| T1415 |
2618-2620 |
IN |
denotes |
in |
| T1416 |
2621-2625 |
CC |
denotes |
both |
| T1417 |
2626-2629 |
DT |
denotes |
the |
| T1418 |
2630-2642 |
NN |
denotes |
upregulation |
| T1419 |
2643-2645 |
IN |
denotes |
of |
| T1420 |
2646-2654 |
JJ |
denotes |
specific |
| T1421 |
2655-2667 |
JJ |
denotes |
inflammasome |
| T1422 |
2668-2678 |
NN |
denotes |
components |
| T1423 |
2679-2680 |
-LRB- |
denotes |
[ |
| T1424 |
2680-2682 |
CD |
denotes |
22 |
| T1425 |
2682-2683 |
-RRB- |
denotes |
] |
| T1426 |
2683-2684 |
-COMMA- |
denotes |
, |
| T1427 |
2685-2686 |
-LRB- |
denotes |
[ |
| T1428 |
2686-2688 |
CD |
denotes |
23 |
| T1429 |
2688-2689 |
-RRB- |
denotes |
] |
| T1430 |
2689-2690 |
-COMMA- |
denotes |
, |
| T1431 |
2691-2693 |
RB |
denotes |
as |
| T1432 |
2694-2698 |
RB |
denotes |
well |
| T1433 |
2699-2701 |
IN |
denotes |
as |
| T1434 |
2702-2707 |
NN |
denotes |
IL-1β |
| T1435 |
2708-2718 |
NN |
denotes |
expression |
| T1436 |
2719-2720 |
-LRB- |
denotes |
[ |
| T1437 |
2720-2722 |
CD |
denotes |
24 |
| T1438 |
2722-2723 |
-RRB- |
denotes |
] |
| T1439 |
2723-2724 |
-COMMA- |
denotes |
, |
| T1440 |
2725-2726 |
-LRB- |
denotes |
[ |
| T1441 |
2726-2728 |
CD |
denotes |
25 |
| T1442 |
2728-2729 |
-RRB- |
denotes |
] |
| T1443 |
2731-2739 |
JJ |
denotes |
Previous |
| T1444 |
2740-2747 |
NN |
denotes |
studies |
| T1445 |
2748-2755 |
VB |
denotes |
support |
| T1446 |
2756-2757 |
DT |
denotes |
a |
| T1447 |
2758-2762 |
NN |
denotes |
role |
| T1448 |
2763-2766 |
IN |
denotes |
for |
| T1449 |
2767-2772 |
NN |
denotes |
IL-1β |
| T1450 |
2773-2775 |
IN |
denotes |
in |
| T1451 |
2776-2779 |
DT |
denotes |
the |
| T1452 |
2780-2792 |
NN |
denotes |
pathogenesis |
| T1453 |
2793-2795 |
IN |
denotes |
of |
| T1454 |
2796-2798 |
NN |
denotes |
CF |
| T1455 |
2799-2811 |
JJ |
denotes |
inflammatory |
| T1456 |
2812-2816 |
NN |
denotes |
lung |
| T1457 |
2817-2824 |
NN |
denotes |
disease |
| T1458 |
2826-2832 |
NN |
denotes |
Levels |
| T1459 |
2833-2835 |
IN |
denotes |
of |
| T1460 |
2836-2841 |
NN |
denotes |
IL-1β |
| T1461 |
2842-2845 |
VB |
denotes |
are |
| T1462 |
2846-2855 |
VB |
denotes |
increased |
| T1463 |
2856-2858 |
IN |
denotes |
in |
| T1464 |
2859-2863 |
NN |
denotes |
BALF |
| T1465 |
2864-2868 |
IN |
denotes |
from |
| T1466 |
2869-2871 |
NN |
denotes |
CF |
| T1467 |
2872-2880 |
NN |
denotes |
patients |
| T1468 |
2881-2885 |
IN |
denotes |
with |
| T1469 |
2886-2895 |
NN |
denotes |
infection |
| T1470 |
2896-2897 |
-LRB- |
denotes |
[ |
| T1471 |
2897-2899 |
CD |
denotes |
21 |
| T1472 |
2899-2900 |
-RRB- |
denotes |
] |
| T1473 |
2900-2901 |
-COMMA- |
denotes |
, |
| T1474 |
2902-2903 |
-LRB- |
denotes |
[ |
| T1475 |
2903-2905 |
CD |
denotes |
26 |
| T1476 |
2905-2906 |
-RRB- |
denotes |
] |
| T1477 |
2906-2907 |
-COMMA- |
denotes |
, |
| T1478 |
2908-2909 |
-LRB- |
denotes |
[ |
| T1479 |
2909-2911 |
CD |
denotes |
27 |
| T1480 |
2911-2912 |
-RRB- |
denotes |
] |
| T1481 |
2912-2913 |
-COMMA- |
denotes |
, |
| T1482 |
2914-2915 |
-LRB- |
denotes |
[ |
| T1483 |
2915-2917 |
CD |
denotes |
28 |
| T1484 |
2917-2918 |
-RRB- |
denotes |
] |
| T1485 |
2919-2922 |
CC |
denotes |
and |
| T1486 |
2923-2927 |
DT |
denotes |
this |
| T1487 |
2928-2936 |
NN |
denotes |
increase |
| T1488 |
2937-2940 |
VB |
denotes |
has |
| T1489 |
2941-2945 |
VB |
denotes |
been |
| T1490 |
2946-2956 |
RB |
denotes |
temporally |
| T1491 |
2957-2967 |
VB |
denotes |
associated |
| T1492 |
2968-2972 |
IN |
denotes |
with |
| T1493 |
2973-2974 |
DT |
denotes |
a |
| T1494 |
2975-2983 |
JJ |
denotes |
clinical |
| T1495 |
2984-2992 |
NN |
denotes |
response |
| T1496 |
2993-2995 |
TO |
denotes |
to |
| T1497 |
2996-3005 |
NN |
denotes |
treatment |
| T1498 |
3006-3007 |
-LRB- |
denotes |
[ |
| T1499 |
3007-3009 |
CD |
denotes |
21 |
| T1500 |
3009-3010 |
-RRB- |
denotes |
] |
| T1501 |
3012-3025 |
NN |
denotes |
Polymorphisms |
| T1502 |
3026-3028 |
IN |
denotes |
in |
| T1503 |
3029-3032 |
DT |
denotes |
the |
| T1504 |
3033-3037 |
NN |
denotes |
IL1B |
| T1505 |
3038-3042 |
NN |
denotes |
gene |
| T1506 |
3043-3047 |
VB |
denotes |
have |
| T1507 |
3048-3052 |
RB |
denotes |
also |
| T1508 |
3053-3057 |
VB |
denotes |
been |
| T1509 |
3058-3068 |
VB |
denotes |
associated |
| T1510 |
3069-3073 |
IN |
denotes |
with |
| T1511 |
3074-3081 |
VB |
denotes |
varying |
| T1512 |
3082-3089 |
NN |
denotes |
degrees |
| T1513 |
3090-3092 |
IN |
denotes |
of |
| T1514 |
3093-3100 |
NN |
denotes |
disease |
| T1515 |
3101-3109 |
NN |
denotes |
severity |
| T1516 |
3110-3112 |
IN |
denotes |
in |
| T1517 |
3113-3115 |
NN |
denotes |
CF |
| T1518 |
3116-3124 |
NN |
denotes |
patients |
| T1519 |
3125-3126 |
-LRB- |
denotes |
[ |
| T1520 |
3126-3128 |
CD |
denotes |
29 |
| T1521 |
3128-3129 |
-RRB- |
denotes |
] |
| T1522 |
3131-3137 |
JJ |
denotes |
Murine |
| T1523 |
3138-3144 |
NN |
denotes |
models |
| T1524 |
3145-3147 |
IN |
denotes |
of |
| T1525 |
3148-3152 |
NN |
denotes |
CFTR |
| T1526 |
3153-3164 |
NN |
denotes |
dysfunction |
| T1527 |
3165-3169 |
VB |
denotes |
have |
| T1528 |
3170-3179 |
VB |
denotes |
exhibited |
| T1529 |
3180-3191 |
JJ |
denotes |
significant |
| T1530 |
3192-3201 |
NN |
denotes |
increases |
| T1531 |
3202-3204 |
IN |
denotes |
in |
| T1532 |
3205-3210 |
NN |
denotes |
IL-1β |
| T1533 |
3211-3221 |
NN |
denotes |
expression |
| T1534 |
3222-3224 |
CC |
denotes |
or |
| T1535 |
3225-3234 |
NN |
denotes |
secretion |
| T1536 |
3235-3237 |
IN |
denotes |
in |
| T1537 |
3238-3249 |
NN |
denotes |
macrophages |
| T1538 |
3250-3251 |
-LRB- |
denotes |
[ |
| T1539 |
3251-3253 |
CD |
denotes |
30 |
| T1540 |
3253-3254 |
-RRB- |
denotes |
] |
| T1541 |
3254-3255 |
-COMMA- |
denotes |
, |
| T1542 |
3256-3257 |
-LRB- |
denotes |
[ |
| T1543 |
3257-3259 |
CD |
denotes |
31 |
| T1544 |
3259-3260 |
-RRB- |
denotes |
] |
| T1545 |
3260-3261 |
-COMMA- |
denotes |
, |
| T1546 |
3262-3265 |
CC |
denotes |
and |
| T1547 |
3266-3273 |
VB |
denotes |
support |
| T1548 |
3274-3277 |
DT |
denotes |
the |
| T1549 |
3278-3288 |
NN |
denotes |
hypothesis |
| T1550 |
3289-3293 |
IN |
denotes |
that |
| T1551 |
3294-3297 |
DT |
denotes |
the |
| T1552 |
3298-3302 |
NN |
denotes |
loss |
| T1553 |
3303-3305 |
IN |
denotes |
of |
| T1554 |
3306-3310 |
NN |
denotes |
CFTR |
| T1555 |
3311-3320 |
VB |
denotes |
increases |
| T1556 |
3321-3326 |
NN |
denotes |
NF-κB |
| T1557 |
3327-3337 |
NN |
denotes |
activation |
| T1558 |
3338-3343 |
IN |
denotes |
under |
| T1559 |
3344-3349 |
JJ |
denotes |
basal |
| T1560 |
3350-3353 |
CC |
denotes |
and |
| T1561 |
3354-3365 |
JJ |
denotes |
stimulatory |
| T1562 |
3366-3376 |
NN |
denotes |
conditions |
| T1563 |
3377-3378 |
-LRB- |
denotes |
[ |
| T1564 |
3378-3379 |
CD |
denotes |
4 |
| T1565 |
3379-3380 |
-RRB- |
denotes |
] |
| T1566 |
3380-3381 |
-COMMA- |
denotes |
, |
| T1567 |
3382-3383 |
-LRB- |
denotes |
[ |
| T1568 |
3383-3384 |
CD |
denotes |
5 |
| T1569 |
3384-3385 |
-RRB- |
denotes |
] |
| T1570 |
3385-3386 |
-COMMA- |
denotes |
, |
| T1571 |
3387-3388 |
-LRB- |
denotes |
[ |
| T1572 |
3388-3390 |
CD |
denotes |
32 |
| T1573 |
3390-3391 |
-RRB- |
denotes |
] |
| T1574 |
3391-3392 |
-COMMA- |
denotes |
, |
| T1575 |
3393-3394 |
-LRB- |
denotes |
[ |
| T1576 |
3394-3396 |
CD |
denotes |
33 |
| T1577 |
3396-3397 |
-RRB- |
denotes |
] |
| T1578 |
3399-3406 |
RB |
denotes |
Finally |
| T1579 |
3406-3407 |
-COMMA- |
denotes |
, |
| T1580 |
3408-3419 |
NN |
denotes |
replacement |
| T1581 |
3420-3422 |
IN |
denotes |
of |
| T1582 |
3423-3431 |
NN |
denotes |
chloride |
| T1583 |
3432-3436 |
NN |
denotes |
ions |
| T1584 |
3437-3441 |
IN |
denotes |
with |
| T1585 |
3442-3451 |
NN |
denotes |
glutamate |
| T1586 |
3452-3454 |
CC |
denotes |
or |
| T1587 |
3455-3464 |
NN |
denotes |
gluconate |
| T1588 |
3465-3467 |
IN |
denotes |
in |
| T1589 |
3468-3472 |
NN |
denotes |
cell |
| T1590 |
3473-3480 |
NN |
denotes |
culture |
| T1591 |
3481-3486 |
NN |
denotes |
media |
| T1592 |
3487-3496 |
VB |
denotes |
increases |
| T1593 |
3497-3506 |
NN |
denotes |
secretion |
| T1594 |
3507-3509 |
IN |
denotes |
of |
| T1595 |
3510-3515 |
NN |
denotes |
IL-1β |
| T1596 |
3516-3518 |
IN |
denotes |
in |
| T1597 |
3519-3527 |
NN |
denotes |
response |
| T1598 |
3528-3530 |
TO |
denotes |
to |
| T1599 |
3531-3536 |
NN |
denotes |
NLRP3 |
| T1600 |
3537-3548 |
NN |
denotes |
stimulation |
| T1601 |
3549-3551 |
IN |
denotes |
by |
| T1602 |
3552-3561 |
NN |
denotes |
adenosine |
| T1603 |
3562-3574 |
NN |
denotes |
triphosphate |
| T1604 |
3575-3576 |
-LRB- |
denotes |
( |
| T1605 |
3576-3579 |
NN |
denotes |
ATP |
| T1606 |
3579-3580 |
-RRB- |
denotes |
) |
| T1607 |
3581-3582 |
-LRB- |
denotes |
[ |
| T1608 |
3582-3584 |
CD |
denotes |
34 |
| T1609 |
3584-3585 |
-RRB- |
denotes |
] |
| T1610 |
3585-3586 |
-COMMA- |
denotes |
, |
| T1611 |
3587-3595 |
VB |
denotes |
implying |
| T1612 |
3596-3598 |
DT |
denotes |
an |
| T1613 |
3599-3609 |
JJ |
denotes |
inhibitory |
| T1614 |
3610-3614 |
NN |
denotes |
role |
| T1615 |
3615-3618 |
IN |
denotes |
for |
| T1616 |
3619-3632 |
JJ |
denotes |
extracellular |
| T1617 |
3633-3641 |
NN |
denotes |
chloride |
| T1618 |
3642-3644 |
IN |
denotes |
in |
| T1619 |
3645-3650 |
NN |
denotes |
NLRP3 |
| T1620 |
3651-3661 |
NN |
denotes |
activation |
| T1621 |
3663-3668 |
VB |
denotes |
Taken |
| T1622 |
3669-3677 |
RB |
denotes |
together |
| T1623 |
3677-3678 |
-COMMA- |
denotes |
, |
| T1624 |
3679-3684 |
DT |
denotes |
these |
| T1625 |
3685-3689 |
NN |
denotes |
data |
| T1626 |
3690-3699 |
VB |
denotes |
implicate |
| T1627 |
3700-3703 |
DT |
denotes |
the |
| T1628 |
3704-3715 |
NN |
denotes |
involvement |
| T1629 |
3716-3718 |
IN |
denotes |
of |
| T1630 |
3719-3724 |
NN |
denotes |
IL-1β |
| T1631 |
3725-3728 |
CC |
denotes |
and |
| T1632 |
3729-3741 |
RB |
denotes |
consequently |
| T1633 |
3741-3742 |
-COMMA- |
denotes |
, |
| T1634 |
3743-3746 |
DT |
denotes |
the |
| T1635 |
3747-3760 |
NN |
denotes |
inflammasomes |
| T1636 |
3760-3761 |
-COMMA- |
denotes |
, |
| T1637 |
3762-3764 |
IN |
denotes |
in |
| T1638 |
3765-3767 |
NN |
denotes |
CF |
| T1639 |
3768-3780 |
JJ |
denotes |
inflammatory |
| T1640 |
3781-3788 |
NN |
denotes |
disease |
| R1000 |
T1212 |
T1210 |
arg1Of |
responses,T |
| R1001 |
T1212 |
T1211 |
arg1Of |
responses,cell |
| R1002 |
T1212 |
T1213 |
arg1Of |
responses,[ |
| R1003 |
T1212 |
T1216 |
arg1Of |
responses,"," |
| R1004 |
T1212 |
T1217 |
arg1Of |
responses,[ |
| R1005 |
T1214 |
T1213 |
arg2Of |
9,[ |
| R1006 |
T1215 |
T1213 |
arg3Of |
],[ |
| R1007 |
T1218 |
T1217 |
arg2Of |
10,[ |
| R1008 |
T1219 |
T1217 |
arg3Of |
],[ |
| R1009 |
T1221 |
T1220 |
arg2Of |
initiation,Following |
| R1010 |
T1221 |
T1222 |
arg1Of |
initiation,of |
| R1011 |
T1226 |
T1222 |
arg2Of |
cascade,of |
| R1012 |
T1226 |
T1223 |
arg1Of |
cascade,the |
| R1013 |
T1226 |
T1224 |
arg1Of |
cascade,NF-κB |
| R1014 |
T1226 |
T1225 |
arg1Of |
cascade,signaling |
| R1015 |
T1228 |
T1229 |
arg1Of |
IL-1β,is |
| R1016 |
T1228 |
T1230 |
arg2Of |
IL-1β,produced |
| R1017 |
T1230 |
T1220 |
arg1Of |
produced,Following |
| R1018 |
T1230 |
T1227 |
arg1Of |
produced,"," |
| R1019 |
T1230 |
T1229 |
arg2Of |
produced,is |
| R1020 |
T1230 |
T1231 |
arg1Of |
produced,in |
| R1021 |
T1230 |
T1234 |
arg1Of |
produced,as |
| R1022 |
T1233 |
T1231 |
arg2Of |
cytosol,in |
| R1023 |
T1233 |
T1232 |
arg1Of |
cytosol,the |
| R1024 |
T1239 |
T1234 |
arg2Of |
pro-IL-1β,as |
| R1025 |
T1239 |
T1235 |
arg1Of |
pro-IL-1β,a |
| R1026 |
T1239 |
T1236 |
arg1Of |
pro-IL-1β,biologically |
| R1027 |
T1239 |
T1237 |
arg1Of |
pro-IL-1β,inactive |
| R1028 |
T1239 |
T1238 |
arg1Of |
pro-IL-1β,full-length |
| R1029 |
T1240 |
T1241 |
arg1Of |
Pro-IL-1β,is |
| R1030 |
T1240 |
T1243 |
arg2Of |
Pro-IL-1β,converted |
| R1031 |
T1240 |
T1264 |
arg1Of |
Pro-IL-1β,mediate |
| R1032 |
T1243 |
T1241 |
arg2Of |
converted,is |
| R1033 |
T1243 |
T1242 |
arg1Of |
converted,subsequently |
| R1034 |
T1243 |
T1244 |
arg1Of |
converted,into |
| R1035 |
T1243 |
T1263 |
arg1Of |
converted,and |
| R1036 |
T1247 |
T1244 |
arg2Of |
form,into |
| R1037 |
T1247 |
T1245 |
arg1Of |
form,its |
| R1038 |
T1247 |
T1246 |
arg1Of |
form,active |
| R1039 |
T1251 |
T1243 |
arg1Of |
complexes,converted |
| R1040 |
T1251 |
T1248 |
arg2Of |
complexes,by |
| R1041 |
T1251 |
T1249 |
arg1Of |
complexes,cytosolic |
| R1042 |
T1251 |
T1250 |
arg1Of |
complexes,protein |
| R1043 |
T1251 |
T1252 |
arg2Of |
complexes,termed |
| R1044 |
T1252 |
T1256 |
arg1Of |
termed,in |
| R1045 |
T1255 |
T1252 |
arg3Of |
assemble,termed |
| R1046 |
T1255 |
T1253 |
arg1Of |
assemble,“inflammasomes.” |
| R1047 |
T1255 |
T1254 |
arg1Of |
assemble,Inflammasomes |
| R1048 |
T1257 |
T1256 |
arg2Of |
response,in |
| R1049 |
T1257 |
T1258 |
arg1Of |
response,to |
| R1050 |
T1262 |
T1258 |
arg2Of |
signals,to |
| R1051 |
T1262 |
T1259 |
arg1Of |
signals,certain |
| R1052 |
T1262 |
T1260 |
arg1Of |
signals,cellular |
| R1053 |
T1262 |
T1261 |
arg1Of |
signals,danger |
| R1054 |
T1264 |
T1263 |
arg2Of |
mediate,and |
| R1055 |
T1266 |
T1264 |
arg2Of |
auto-activation,mediate |
| R1056 |
T1266 |
T1265 |
arg1Of |
auto-activation,the |
| R1057 |
T1266 |
T1267 |
arg1Of |
auto-activation,of |
| R1058 |
T1266 |
T1273 |
arg1Of |
auto-activation,[ |
| R1059 |
T1266 |
T1276 |
arg1Of |
auto-activation,"," |
| R1060 |
T1266 |
T1277 |
arg1Of |
auto-activation,which |
| R1061 |
T1266 |
T1278 |
arg1Of |
auto-activation,cleaves |
| R1062 |
T1268 |
T1267 |
arg2Of |
caspase-1,of |
| R1063 |
T1268 |
T1269 |
arg1Of |
caspase-1,[ |
| R1064 |
T1268 |
T1272 |
arg1Of |
caspase-1,"," |
| R1065 |
T1270 |
T1269 |
arg2Of |
9,[ |
| R1066 |
T1271 |
T1269 |
arg3Of |
],[ |
| R1067 |
T1274 |
T1273 |
arg2Of |
11,[ |
| R1068 |
T1275 |
T1273 |
arg3Of |
],[ |
| R1069 |
T1279 |
T1280 |
arg1Of |
pro-IL-1β,and |
| R1070 |
T1280 |
T1278 |
arg2Of |
and,cleaves |
| R1071 |
T1280 |
T1282 |
arg1Of |
and,into |
| R1072 |
T1281 |
T1280 |
arg2Of |
pro-IL-18,and |
| R1073 |
T1285 |
T1284 |
arg1Of |
active,biologically |
| R1074 |
T1286 |
T1282 |
arg2Of |
forms,into |
| R1075 |
T1286 |
T1283 |
arg1Of |
forms,their |
| R1076 |
T1286 |
T1285 |
arg1Of |
forms,active |
| R1077 |
T1286 |
T1287 |
arg1Of |
forms,for |
| R1078 |
T1288 |
T1287 |
arg2Of |
secretion,for |
| R1079 |
T1291 |
T1289 |
arg1Of |
inflammasomes,Four |
| R1080 |
T1291 |
T1290 |
arg1Of |
inflammasomes,distinct |
| R1081 |
T1291 |
T1292 |
arg1Of |
inflammasomes,have |
| R1082 |
T1291 |
T1293 |
arg1Of |
inflammasomes,been |
| R1083 |
T1291 |
T1294 |
arg2Of |
inflammasomes,recognized |
| R1084 |
T1294 |
T1292 |
arg2Of |
recognized,have |
| R1085 |
T1294 |
T1293 |
arg2Of |
recognized,been |
| R1086 |
T1295 |
T1296 |
arg1Of |
These,are |
| R1087 |
T1298 |
T1299 |
arg1Of |
NLRP1,[ |
| R1088 |
T1298 |
T1302 |
arg1Of |
NLRP1,"," |
| R1089 |
T1300 |
T1299 |
arg2Of |
12,[ |
| R1090 |
T1301 |
T1299 |
arg3Of |
],[ |
| R1091 |
T1302 |
T1297 |
arg1Of |
",",the |
| R1092 |
T1302 |
T1307 |
arg1Of |
",","," |
| R1093 |
T1302 |
T1308 |
arg1Of |
",",[ |
| R1094 |
T1302 |
T1311 |
arg1Of |
",","," |
| R1095 |
T1303 |
T1302 |
arg2Of |
NLRP3,"," |
| R1096 |
T1303 |
T1304 |
arg1Of |
NLRP3,[ |
| R1097 |
T1305 |
T1304 |
arg2Of |
13,[ |
| R1098 |
T1306 |
T1304 |
arg3Of |
],[ |
| R1099 |
T1309 |
T1308 |
arg2Of |
14,[ |
| R1100 |
T1310 |
T1308 |
arg3Of |
],[ |
| R1101 |
T1311 |
T1317 |
arg1Of |
",",[ |
| R1102 |
T1311 |
T1321 |
arg1Of |
",",and |
| R1103 |
T1312 |
T1311 |
arg2Of |
NLRC4,"," |
| R1104 |
T1312 |
T1313 |
arg1Of |
NLRC4,[ |
| R1105 |
T1312 |
T1316 |
arg1Of |
NLRC4,"," |
| R1106 |
T1314 |
T1313 |
arg2Of |
15,[ |
| R1107 |
T1315 |
T1313 |
arg3Of |
],[ |
| R1108 |
T1318 |
T1317 |
arg2Of |
16,[ |
| R1109 |
T1319 |
T1317 |
arg3Of |
],[ |
| R1110 |
T1321 |
T1296 |
arg2Of |
and,are |
| R1111 |
T1321 |
T1320 |
arg1Of |
and,"," |
| R1112 |
T1323 |
T1321 |
arg2Of |
inflammasomes,and |
| R1113 |
T1323 |
T1322 |
arg1Of |
inflammasomes,AIM2 |
| R1114 |
T1323 |
T1324 |
arg1Of |
inflammasomes,[ |
| R1115 |
T1323 |
T1327 |
arg1Of |
inflammasomes,"," |
| R1116 |
T1323 |
T1328 |
arg1Of |
inflammasomes,[ |
| R1117 |
T1323 |
T1331 |
arg1Of |
inflammasomes,"," |
| R1118 |
T1323 |
T1332 |
arg1Of |
inflammasomes,which |
| R1119 |
T1323 |
T1333 |
arg1Of |
inflammasomes,respond |
| R1120 |
T1325 |
T1324 |
arg2Of |
17,[ |
| R1121 |
T1326 |
T1324 |
arg3Of |
],[ |
| R1122 |
T1329 |
T1328 |
arg2Of |
18,[ |
| R1123 |
T1330 |
T1328 |
arg3Of |
],[ |
| R1124 |
T1333 |
T1334 |
arg1Of |
respond,to |
| R1125 |
T1336 |
T1334 |
arg2Of |
variety,to |
| R1126 |
T1336 |
T1335 |
arg1Of |
variety,a |
| R1127 |
T1336 |
T1337 |
arg1Of |
variety,of |
| R1128 |
T1340 |
T1338 |
arg1Of |
signatures,different |
| R1129 |
T1340 |
T1339 |
arg1Of |
signatures,microbial |
| R1130 |
T1340 |
T1341 |
arg1Of |
signatures,and |
| R1131 |
T1341 |
T1337 |
arg2Of |
and,of |
| R1132 |
T1343 |
T1341 |
arg2Of |
signals,and |
| R1133 |
T1343 |
T1342 |
arg1Of |
signals,danger |
| R1134 |
T1343 |
T1344 |
arg1Of |
signals,[ |
| R1135 |
T1345 |
T1344 |
arg2Of |
11,[ |
| R1136 |
T1346 |
T1344 |
arg3Of |
],[ |
| R1137 |
T1348 |
T1347 |
arg1Of |
aeruginosa,P. |
| R1138 |
T1348 |
T1349 |
arg1Of |
aeruginosa,"," |
| R1139 |
T1348 |
T1363 |
arg1Of |
aeruginosa,activates |
| R1140 |
T1350 |
T1349 |
arg2Of |
one,"," |
| R1141 |
T1350 |
T1351 |
arg1Of |
one,of |
| R1142 |
T1350 |
T1359 |
arg1Of |
one,among |
| R1143 |
T1354 |
T1353 |
arg1Of |
common,most |
| R1144 |
T1354 |
T1355 |
arg1Of |
common,and |
| R1145 |
T1357 |
T1355 |
arg2Of |
relevant,and |
| R1146 |
T1357 |
T1356 |
arg1Of |
relevant,clinically |
| R1147 |
T1358 |
T1351 |
arg2Of |
pathogens,of |
| R1148 |
T1358 |
T1352 |
arg1Of |
pathogens,the |
| R1149 |
T1358 |
T1354 |
arg1Of |
pathogens,common |
| R1150 |
T1358 |
T1357 |
arg1Of |
pathogens,relevant |
| R1151 |
T1361 |
T1359 |
arg2Of |
patients,among |
| R1152 |
T1361 |
T1360 |
arg1Of |
patients,CF |
| R1153 |
T1363 |
T1362 |
arg1Of |
activates,"," |
| R1154 |
T1363 |
T1370 |
arg1Of |
activates,"," |
| R1155 |
T1363 |
T1371 |
arg1Of |
activates,[ |
| R1156 |
T1366 |
T1363 |
arg2Of |
inflammasome,activates |
| R1157 |
T1366 |
T1364 |
arg1Of |
inflammasome,the |
| R1158 |
T1366 |
T1365 |
arg1Of |
inflammasome,NLRC4 |
| R1159 |
T1366 |
T1367 |
arg1Of |
inflammasome,[ |
| R1160 |
T1368 |
T1367 |
arg2Of |
19,[ |
| R1161 |
T1369 |
T1367 |
arg3Of |
],[ |
| R1162 |
T1372 |
T1371 |
arg2Of |
20,[ |
| R1163 |
T1373 |
T1371 |
arg3Of |
],[ |
| R1164 |
T1374 |
T1375 |
arg1Of |
Infection,with |
| R1165 |
T1374 |
T1378 |
arg1Of |
Infection,triggers |
| R1166 |
T1377 |
T1375 |
arg2Of |
aeruginosa,with |
| R1167 |
T1377 |
T1376 |
arg1Of |
aeruginosa,P. |
| R1168 |
T1378 |
T1401 |
arg1Of |
triggers,[ |
| R1169 |
T1380 |
T1378 |
arg2Of |
increase,triggers |
| R1170 |
T1380 |
T1379 |
arg1Of |
increase,an |
| R1171 |
T1380 |
T1381 |
arg1Of |
increase,in |
| R1172 |
T1380 |
T1390 |
arg1Of |
increase,in |
| R1173 |
T1382 |
T1381 |
arg2Of |
levels,in |
| R1174 |
T1382 |
T1383 |
arg1Of |
levels,of |
| R1175 |
T1384 |
T1385 |
arg1Of |
IL-1β,"," |
| R1176 |
T1385 |
T1388 |
arg1Of |
",",and |
| R1177 |
T1386 |
T1385 |
arg2Of |
IL-6,"," |
| R1178 |
T1388 |
T1383 |
arg2Of |
and,of |
| R1179 |
T1388 |
T1387 |
arg1Of |
and,"," |
| R1180 |
T1389 |
T1388 |
arg2Of |
IL-8,and |
| R1181 |
T1393 |
T1390 |
arg2Of |
fluid,in |
| R1182 |
T1393 |
T1391 |
arg1Of |
fluid,bronchoalveolar |
| R1183 |
T1393 |
T1392 |
arg1Of |
fluid,lavage |
| R1184 |
T1393 |
T1394 |
arg1Of |
fluid,( |
| R1185 |
T1393 |
T1397 |
arg1Of |
fluid,from |
| R1186 |
T1395 |
T1394 |
arg2Of |
BALF,( |
| R1187 |
T1396 |
T1394 |
arg3Of |
),( |
| R1188 |
T1398 |
T1397 |
arg2Of |
patients,from |
| R1189 |
T1398 |
T1399 |
arg1Of |
patients,with |
| R1190 |
T1400 |
T1399 |
arg2Of |
CF,with |
| R1191 |
T1402 |
T1401 |
arg2Of |
21,[ |
| R1192 |
T1403 |
T1401 |
arg3Of |
],[ |
| R1193 |
T1405 |
T1404 |
arg1Of |
responses,Inflammasome |
| R1194 |
T1405 |
T1406 |
arg1Of |
responses,depend |
| R1195 |
T1406 |
T1407 |
arg1Of |
depend,on |
| R1196 |
T1406 |
T1436 |
arg1Of |
depend,[ |
| R1197 |
T1406 |
T1439 |
arg1Of |
depend,"," |
| R1198 |
T1406 |
T1440 |
arg1Of |
depend,[ |
| R1199 |
T1409 |
T1408 |
arg1Of |
signaling,NF-κB |
| R1200 |
T1409 |
T1410 |
arg1Of |
signaling,"," |
| R1201 |
T1409 |
T1411 |
arg1Of |
signaling,where |
| R1202 |
T1409 |
T1426 |
arg1Of |
signaling,"," |
| R1203 |
T1409 |
T1427 |
arg1Of |
signaling,[ |
| R1204 |
T1409 |
T1433 |
arg1Of |
signaling,as |
| R1205 |
T1412 |
T1413 |
arg1Of |
NF-κB,is |
| R1206 |
T1412 |
T1414 |
arg1Of |
NF-κB,important |
| R1207 |
T1413 |
T1411 |
arg2Of |
is,where |
| R1208 |
T1414 |
T1413 |
arg2Of |
important,is |
| R1209 |
T1414 |
T1415 |
arg1Of |
important,in |
| R1210 |
T1418 |
T1415 |
arg2Of |
upregulation,in |
| R1211 |
T1418 |
T1416 |
arg1Of |
upregulation,both |
| R1212 |
T1418 |
T1417 |
arg1Of |
upregulation,the |
| R1213 |
T1418 |
T1419 |
arg1Of |
upregulation,of |
| R1214 |
T1422 |
T1419 |
arg2Of |
components,of |
| R1215 |
T1422 |
T1420 |
arg1Of |
components,specific |
| R1216 |
T1422 |
T1421 |
arg1Of |
components,inflammasome |
| R1217 |
T1422 |
T1423 |
arg1Of |
components,[ |
| R1218 |
T1424 |
T1423 |
arg2Of |
22,[ |
| R1219 |
T1425 |
T1423 |
arg3Of |
],[ |
| R1220 |
T1428 |
T1427 |
arg2Of |
23,[ |
| R1221 |
T1429 |
T1427 |
arg3Of |
],[ |
| R1222 |
T1433 |
T1407 |
arg2Of |
as,on |
| R1223 |
T1433 |
T1430 |
arg1Of |
as,"," |
| R1224 |
T1433 |
T1431 |
arg1Of |
as,as |
| R1225 |
T1433 |
T1432 |
arg1Of |
as,well |
| R1226 |
T1435 |
T1433 |
arg2Of |
expression,as |
| R1227 |
T1435 |
T1434 |
arg1Of |
expression,IL-1β |
| R1228 |
T1437 |
T1436 |
arg2Of |
24,[ |
| R1229 |
T1438 |
T1436 |
arg3Of |
],[ |
| R1230 |
T1441 |
T1440 |
arg2Of |
25,[ |
| R1231 |
T1442 |
T1440 |
arg3Of |
],[ |
| R1232 |
T1444 |
T1443 |
arg1Of |
studies,Previous |
| R1233 |
T1444 |
T1445 |
arg1Of |
studies,support |
| R1234 |
T1447 |
T1445 |
arg2Of |
role,support |
| R1235 |
T1447 |
T1446 |
arg1Of |
role,a |
| R1236 |
T1447 |
T1448 |
arg1Of |
role,for |
| R1237 |
T1447 |
T1450 |
arg1Of |
role,in |
| R1238 |
T1449 |
T1448 |
arg2Of |
IL-1β,for |
| R1239 |
T1452 |
T1450 |
arg2Of |
pathogenesis,in |
| R1240 |
T1452 |
T1451 |
arg1Of |
pathogenesis,the |
| R1241 |
T1452 |
T1453 |
arg1Of |
pathogenesis,of |
| R1242 |
T1457 |
T1453 |
arg2Of |
disease,of |
| R1243 |
T1457 |
T1454 |
arg1Of |
disease,CF |
| R1244 |
T1457 |
T1455 |
arg1Of |
disease,inflammatory |
| R1245 |
T1457 |
T1456 |
arg1Of |
disease,lung |
| R1246 |
T1458 |
T1459 |
arg1Of |
Levels,of |
| R1247 |
T1458 |
T1461 |
arg1Of |
Levels,are |
| R1248 |
T1458 |
T1462 |
arg2Of |
Levels,increased |
| R1249 |
T1460 |
T1459 |
arg2Of |
IL-1β,of |
| R1250 |
T1462 |
T1461 |
arg2Of |
increased,are |
| R1251 |
T1462 |
T1463 |
arg1Of |
increased,in |
| R1252 |
T1462 |
T1473 |
arg1Of |
increased,"," |
| R1253 |
T1462 |
T1474 |
arg1Of |
increased,[ |
| R1254 |
T1462 |
T1477 |
arg1Of |
increased,"," |
| R1255 |
T1462 |
T1478 |
arg1Of |
increased,[ |
| R1256 |
T1462 |
T1481 |
arg1Of |
increased,"," |
| R1257 |
T1462 |
T1482 |
arg1Of |
increased,[ |
| R1258 |
T1462 |
T1485 |
arg1Of |
increased,and |
| R1259 |
T1464 |
T1463 |
arg2Of |
BALF,in |
| R1260 |
T1464 |
T1465 |
arg1Of |
BALF,from |
| R1261 |
T1467 |
T1465 |
arg2Of |
patients,from |
| R1262 |
T1467 |
T1466 |
arg1Of |
patients,CF |
| R1263 |
T1467 |
T1468 |
arg1Of |
patients,with |
| R1264 |
T1469 |
T1468 |
arg2Of |
infection,with |
| R1265 |
T1469 |
T1470 |
arg1Of |
infection,[ |
| R1266 |
T1471 |
T1470 |
arg2Of |
21,[ |
| R1267 |
T1472 |
T1470 |
arg3Of |
],[ |
| R1268 |
T1475 |
T1474 |
arg2Of |
26,[ |
| R1269 |
T1476 |
T1474 |
arg3Of |
],[ |
| R1270 |
T1479 |
T1478 |
arg2Of |
27,[ |
| R1271 |
T1480 |
T1478 |
arg3Of |
],[ |
| R1272 |
T1483 |
T1482 |
arg2Of |
28,[ |
| R1273 |
T1484 |
T1482 |
arg3Of |
],[ |
| R1274 |
T1487 |
T1486 |
arg1Of |
increase,this |
| R1275 |
T1487 |
T1488 |
arg1Of |
increase,has |
| R1276 |
T1487 |
T1489 |
arg1Of |
increase,been |
| R1277 |
T1487 |
T1491 |
arg2Of |
increase,associated |
| R1278 |
T1491 |
T1485 |
arg2Of |
associated,and |
| R1279 |
T1491 |
T1488 |
arg2Of |
associated,has |
| R1280 |
T1491 |
T1489 |
arg2Of |
associated,been |
| R1281 |
T1491 |
T1490 |
arg1Of |
associated,temporally |
| R1282 |
T1491 |
T1492 |
arg1Of |
associated,with |
| R1283 |
T1495 |
T1492 |
arg2Of |
response,with |
| R1284 |
T1495 |
T1493 |
arg1Of |
response,a |
| R1285 |
T1495 |
T1494 |
arg1Of |
response,clinical |
| R1286 |
T1495 |
T1496 |
arg1Of |
response,to |
| R1287 |
T1497 |
T1496 |
arg2Of |
treatment,to |
| R1288 |
T1497 |
T1498 |
arg1Of |
treatment,[ |
| R1289 |
T1499 |
T1498 |
arg2Of |
21,[ |
| R1290 |
T1500 |
T1498 |
arg3Of |
],[ |
| R1291 |
T1501 |
T1502 |
arg1Of |
Polymorphisms,in |
| R1292 |
T1501 |
T1506 |
arg1Of |
Polymorphisms,have |
| R1293 |
T1501 |
T1508 |
arg1Of |
Polymorphisms,been |
| R1294 |
T1501 |
T1509 |
arg2Of |
Polymorphisms,associated |
| R1295 |
T1505 |
T1502 |
arg2Of |
gene,in |
| R1296 |
T1505 |
T1503 |
arg1Of |
gene,the |
| R1297 |
T1505 |
T1504 |
arg1Of |
gene,IL1B |
| R1298 |
T1509 |
T1506 |
arg2Of |
associated,have |
| R1299 |
T1509 |
T1507 |
arg1Of |
associated,also |
| R1300 |
T1509 |
T1508 |
arg2Of |
associated,been |
| R1301 |
T1509 |
T1510 |
arg1Of |
associated,with |
| R1302 |
T1509 |
T1519 |
arg1Of |
associated,[ |
| R1303 |
T1512 |
T1510 |
arg2Of |
degrees,with |
| R1304 |
T1512 |
T1511 |
arg1Of |
degrees,varying |
| R1305 |
T1512 |
T1513 |
arg1Of |
degrees,of |
| R1306 |
T1512 |
T1516 |
arg1Of |
degrees,in |
| R1307 |
T1515 |
T1513 |
arg2Of |
severity,of |
| R1308 |
T1515 |
T1514 |
arg1Of |
severity,disease |
| R1309 |
T1518 |
T1516 |
arg2Of |
patients,in |
| R1310 |
T1518 |
T1517 |
arg1Of |
patients,CF |
| R1311 |
T1520 |
T1519 |
arg2Of |
29,[ |
| R1312 |
T1521 |
T1519 |
arg3Of |
],[ |
| R1313 |
T1523 |
T1522 |
arg1Of |
models,Murine |
| R1314 |
T1523 |
T1524 |
arg1Of |
models,of |
| R1315 |
T1523 |
T1527 |
arg1Of |
models,have |
| R1316 |
T1523 |
T1528 |
arg1Of |
models,exhibited |
| R1317 |
T1523 |
T1547 |
arg1Of |
models,support |
| R1318 |
T1526 |
T1524 |
arg2Of |
dysfunction,of |
| R1319 |
T1526 |
T1525 |
arg1Of |
dysfunction,CFTR |
| R1320 |
T1528 |
T1527 |
arg2Of |
exhibited,have |
| R1321 |
T1528 |
T1541 |
arg1Of |
exhibited,"," |
| R1322 |
T1528 |
T1542 |
arg1Of |
exhibited,[ |
| R1323 |
T1528 |
T1546 |
arg1Of |
exhibited,and |
| R1324 |
T1530 |
T1528 |
arg2Of |
increases,exhibited |
| R1325 |
T1530 |
T1529 |
arg1Of |
increases,significant |
| R1326 |
T1530 |
T1531 |
arg1Of |
increases,in |
| R1327 |
T1533 |
T1534 |
arg1Of |
expression,or |
| R1328 |
T1534 |
T1531 |
arg2Of |
or,in |
| R1329 |
T1534 |
T1532 |
arg1Of |
or,IL-1β |
| R1330 |
T1534 |
T1536 |
arg1Of |
or,in |
| R1331 |
T1535 |
T1534 |
arg2Of |
secretion,or |
| R1332 |
T1537 |
T1536 |
arg2Of |
macrophages,in |
| R1333 |
T1537 |
T1538 |
arg1Of |
macrophages,[ |
| R1334 |
T1539 |
T1538 |
arg2Of |
30,[ |
| R1335 |
T1540 |
T1538 |
arg3Of |
],[ |
| R1336 |
T1543 |
T1542 |
arg2Of |
31,[ |
| R1337 |
T1544 |
T1542 |
arg3Of |
],[ |
| R1338 |
T1546 |
T1545 |
arg1Of |
and,"," |
| R1339 |
T1547 |
T1546 |
arg2Of |
support,and |
| R1340 |
T1547 |
T1574 |
arg1Of |
support,"," |
| R1341 |
T1547 |
T1575 |
arg1Of |
support,[ |
| R1342 |
T1549 |
T1547 |
arg2Of |
hypothesis,support |
| R1343 |
T1549 |
T1548 |
arg1Of |
hypothesis,the |
| R1344 |
T1552 |
T1551 |
arg1Of |
loss,the |
| R1345 |
T1552 |
T1553 |
arg1Of |
loss,of |
| R1346 |
T1552 |
T1555 |
arg1Of |
loss,increases |
| R1347 |
T1554 |
T1553 |
arg2Of |
CFTR,of |
| R1348 |
T1555 |
T1549 |
arg2Of |
increases,hypothesis |
| R1349 |
T1555 |
T1550 |
arg1Of |
increases,that |
| R1350 |
T1555 |
T1558 |
arg1Of |
increases,under |
| R1351 |
T1555 |
T1566 |
arg1Of |
increases,"," |
| R1352 |
T1555 |
T1567 |
arg1Of |
increases,[ |
| R1353 |
T1555 |
T1570 |
arg1Of |
increases,"," |
| R1354 |
T1555 |
T1571 |
arg1Of |
increases,[ |
| R1355 |
T1557 |
T1555 |
arg2Of |
activation,increases |
| R1356 |
T1557 |
T1556 |
arg1Of |
activation,NF-κB |
| R1357 |
T1559 |
T1560 |
arg1Of |
basal,and |
| R1358 |
T1561 |
T1560 |
arg2Of |
stimulatory,and |
| R1359 |
T1562 |
T1558 |
arg2Of |
conditions,under |
| R1360 |
T1562 |
T1559 |
arg1Of |
conditions,basal |
| R1361 |
T1562 |
T1561 |
arg1Of |
conditions,stimulatory |
| R1362 |
T1562 |
T1563 |
arg1Of |
conditions,[ |
| R1363 |
T1564 |
T1563 |
arg2Of |
4,[ |
| R1364 |
T1565 |
T1563 |
arg3Of |
],[ |
| R1365 |
T1568 |
T1567 |
arg2Of |
5,[ |
| R1366 |
T1569 |
T1567 |
arg3Of |
],[ |
| R1367 |
T1572 |
T1571 |
arg2Of |
32,[ |
| R1368 |
T1573 |
T1571 |
arg3Of |
],[ |
| R1369 |
T1576 |
T1575 |
arg2Of |
33,[ |
| R1370 |
T1577 |
T1575 |
arg3Of |
],[ |
| R1371 |
T1580 |
T1581 |
arg1Of |
replacement,of |
| R1372 |
T1580 |
T1592 |
arg1Of |
replacement,increases |
| R1373 |
T1583 |
T1581 |
arg2Of |
ions,of |
| R1374 |
T1583 |
T1582 |
arg1Of |
ions,chloride |
| R1375 |
T1583 |
T1584 |
arg1Of |
ions,with |
| R1376 |
T1585 |
T1586 |
arg1Of |
glutamate,or |
| R1377 |
T1586 |
T1584 |
arg2Of |
or,with |
| R1378 |
T1586 |
T1588 |
arg1Of |
or,in |
| R1379 |
T1587 |
T1586 |
arg2Of |
gluconate,or |
| R1380 |
T1591 |
T1588 |
arg2Of |
media,in |
| R1381 |
T1591 |
T1589 |
arg1Of |
media,cell |
| R1382 |
T1591 |
T1590 |
arg1Of |
media,culture |
| R1383 |
T1592 |
T1578 |
arg1Of |
increases,Finally |
| R1384 |
T1592 |
T1579 |
arg1Of |
increases,"," |
| R1385 |
T1592 |
T1596 |
arg1Of |
increases,in |
| R1386 |
T1592 |
T1610 |
arg1Of |
increases,"," |
| R1387 |
T1592 |
T1611 |
modOf |
increases,implying |
| R1388 |
T1593 |
T1592 |
arg2Of |
secretion,increases |
| R1389 |
T1593 |
T1594 |
arg1Of |
secretion,of |
| R1390 |
T1595 |
T1594 |
arg2Of |
IL-1β,of |
| R1391 |
T1597 |
T1596 |
arg2Of |
response,in |
| R1392 |
T1597 |
T1598 |
arg1Of |
response,to |
| R1393 |
T1600 |
T1598 |
arg2Of |
stimulation,to |
| R1394 |
T1600 |
T1599 |
arg1Of |
stimulation,NLRP3 |
| R1395 |
T1600 |
T1601 |
arg1Of |
stimulation,by |
| R1396 |
T1603 |
T1601 |
arg2Of |
triphosphate,by |
| R1397 |
T1603 |
T1602 |
arg1Of |
triphosphate,adenosine |
| R1398 |
T1603 |
T1604 |
arg1Of |
triphosphate,( |
| R1399 |
T1603 |
T1607 |
arg1Of |
triphosphate,[ |
| R1400 |
T1605 |
T1604 |
arg2Of |
ATP,( |
| R1401 |
T1606 |
T1604 |
arg3Of |
),( |
| R1402 |
T1608 |
T1607 |
arg2Of |
34,[ |
| R1403 |
T1609 |
T1607 |
arg3Of |
],[ |
| R1404 |
T1614 |
T1611 |
arg2Of |
role,implying |
| R1405 |
T1614 |
T1612 |
arg1Of |
role,an |
| R1406 |
T1614 |
T1613 |
arg1Of |
role,inhibitory |
| R1407 |
T1614 |
T1615 |
arg1Of |
role,for |
| R1408 |
T1614 |
T1618 |
arg1Of |
role,in |
| R1409 |
T1617 |
T1615 |
arg2Of |
chloride,for |
| R1410 |
T1617 |
T1616 |
arg1Of |
chloride,extracellular |
| R1411 |
T1620 |
T1618 |
arg2Of |
activation,in |
| R1412 |
T1620 |
T1619 |
arg1Of |
activation,NLRP3 |
| R1413 |
T1621 |
T1622 |
arg1Of |
Taken,together |
| R1414 |
T1625 |
T1624 |
arg1Of |
data,these |
| R1415 |
T1625 |
T1626 |
arg1Of |
data,implicate |
| R1416 |
T1626 |
T1621 |
modOf |
implicate,Taken |
| R1417 |
T1626 |
T1623 |
arg1Of |
implicate,"," |
| R1418 |
T1626 |
T1636 |
arg1Of |
implicate,"," |
| R1419 |
T1626 |
T1637 |
arg1Of |
implicate,in |
| R1420 |
T1628 |
T1626 |
arg2Of |
involvement,implicate |
| R1421 |
T1628 |
T1627 |
arg1Of |
involvement,the |
| R1422 |
T1628 |
T1629 |
arg1Of |
involvement,of |
| R1423 |
T1628 |
T1632 |
arg1Of |
involvement,consequently |
| R1424 |
T1628 |
T1633 |
arg1Of |
involvement,"," |
| R1425 |
T1629 |
T1631 |
arg1Of |
of,and |
| R1426 |
T1630 |
T1629 |
arg2Of |
IL-1β,of |
| R1427 |
T1632 |
T1631 |
arg2Of |
consequently,and |
| R1428 |
T1635 |
T1633 |
arg2Of |
inflammasomes,"," |
| R1429 |
T1635 |
T1634 |
arg1Of |
inflammasomes,the |
| R1430 |
T1640 |
T1637 |
arg2Of |
disease,in |
| R1431 |
T1640 |
T1638 |
arg1Of |
disease,CF |
| R1432 |
T1640 |
T1639 |
arg1Of |
disease,inflammatory |
| R736 |
T953 |
T952 |
arg1Of |
fibrosis,Cystic |
| R737 |
T953 |
T954 |
arg1Of |
fibrosis,is |
| R738 |
T958 |
T954 |
arg2Of |
disease,is |
| R739 |
T958 |
T955 |
arg1Of |
disease,an |
| R740 |
T958 |
T956 |
arg1Of |
disease,autosomal |
| R741 |
T958 |
T957 |
arg1Of |
disease,recessive |
| R742 |
T958 |
T959 |
arg2Of |
disease,caused |
| R743 |
T961 |
T959 |
arg1Of |
mutations,caused |
| R744 |
T961 |
T960 |
arg2Of |
mutations,by |
| R745 |
T961 |
T962 |
arg1Of |
mutations,in |
| R746 |
T968 |
T962 |
arg2Of |
regulator,in |
| R747 |
T968 |
T963 |
arg1Of |
regulator,the |
| R748 |
T968 |
T964 |
arg1Of |
regulator,cystic |
| R749 |
T968 |
T965 |
arg1Of |
regulator,fibrosis |
| R750 |
T968 |
T966 |
arg1Of |
regulator,transmembrane |
| R751 |
T968 |
T967 |
arg1Of |
regulator,conductance |
| R752 |
T968 |
T969 |
arg1Of |
regulator,( |
| R753 |
T968 |
T972 |
arg1Of |
regulator,"," |
| R754 |
T968 |
T973 |
arg1Of |
regulator,which |
| R755 |
T968 |
T974 |
arg1Of |
regulator,functions |
| R756 |
T970 |
T969 |
arg2Of |
CFTR,( |
| R757 |
T971 |
T969 |
arg3Of |
),( |
| R758 |
T974 |
T975 |
arg1Of |
functions,as |
| R759 |
T979 |
T975 |
arg2Of |
channel,as |
| R760 |
T979 |
T976 |
arg1Of |
channel,a |
| R761 |
T979 |
T977 |
arg1Of |
channel,chloride |
| R762 |
T979 |
T978 |
arg1Of |
channel,ion |
| R763 |
T980 |
T981 |
arg1Of |
CF,remains |
| R764 |
T981 |
T1008 |
arg1Of |
remains,[ |
| R765 |
T981 |
T1011 |
arg1Of |
remains,"," |
| R766 |
T981 |
T1012 |
arg1Of |
remains,[ |
| R767 |
T982 |
T981 |
arg2Of |
one,remains |
| R768 |
T982 |
T983 |
arg1Of |
one,of |
| R769 |
T982 |
T990 |
arg1Of |
one,in |
| R770 |
T986 |
T985 |
arg1Of |
common,most |
| R771 |
T989 |
T983 |
arg2Of |
diseases,of |
| R772 |
T989 |
T984 |
arg1Of |
diseases,the |
| R773 |
T989 |
T986 |
arg1Of |
diseases,common |
| R774 |
T989 |
T987 |
arg1Of |
diseases,lethal |
| R775 |
T989 |
T988 |
arg1Of |
diseases,genetic |
| R776 |
T991 |
T990 |
arg2Of |
populations,in |
| R777 |
T991 |
T992 |
arg1Of |
populations,of |
| R778 |
T991 |
T995 |
arg1Of |
populations,with |
| R779 |
T991 |
T1003 |
arg1Of |
populations,approximately |
| R780 |
T994 |
T992 |
arg2Of |
descent,of |
| R781 |
T994 |
T993 |
arg1Of |
descent,European |
| R782 |
T999 |
T995 |
arg2Of |
lifespan,with |
| R783 |
T999 |
T996 |
arg1Of |
lifespan,the |
| R784 |
T999 |
T997 |
arg1Of |
lifespan,current |
| R785 |
T999 |
T998 |
arg1Of |
lifespan,average |
| R786 |
T999 |
T1000 |
arg1Of |
lifespan,of |
| R787 |
T1002 |
T1000 |
arg2Of |
patients,of |
| R788 |
T1002 |
T1001 |
arg1Of |
patients,CF |
| R789 |
T1003 |
T1005 |
arg1Of |
approximately,years |
| R790 |
T1005 |
T1004 |
arg1Of |
years,40 |
| R791 |
T1005 |
T1006 |
arg1Of |
years,of |
| R792 |
T1007 |
T1006 |
arg2Of |
age,of |
| R793 |
T1009 |
T1008 |
arg2Of |
1,[ |
| R794 |
T1010 |
T1008 |
arg3Of |
],[ |
| R795 |
T1013 |
T1012 |
arg2Of |
2,[ |
| R796 |
T1014 |
T1012 |
arg3Of |
],[ |
| R797 |
T1018 |
T1015 |
arg1Of |
exacerbation,Recurrent |
| R798 |
T1018 |
T1016 |
arg1Of |
exacerbation,inflammatory |
| R799 |
T1018 |
T1017 |
arg1Of |
exacerbation,pulmonary |
| R800 |
T1018 |
T1019 |
arg1Of |
exacerbation,is |
| R801 |
T1022 |
T1021 |
arg1Of |
cause,primary |
| R802 |
T1022 |
T1023 |
arg1Of |
cause,of |
| R803 |
T1022 |
T1028 |
arg1Of |
cause,ultimately |
| R804 |
T1022 |
T1029 |
arg1Of |
cause,"," |
| R805 |
T1023 |
T1027 |
arg1Of |
of,and |
| R806 |
T1026 |
T1023 |
arg2Of |
progression,of |
| R807 |
T1026 |
T1024 |
arg1Of |
progression,lung |
| R808 |
T1026 |
T1025 |
arg1Of |
progression,disease |
| R809 |
T1028 |
T1027 |
arg2Of |
ultimately,and |
| R810 |
T1029 |
T1019 |
arg2Of |
",",is |
| R811 |
T1029 |
T1020 |
arg1Of |
",",the |
| R812 |
T1029 |
T1031 |
arg1Of |
",",in |
| R813 |
T1030 |
T1029 |
arg2Of |
death,"," |
| R814 |
T1032 |
T1031 |
arg2Of |
CF,in |
| R815 |
T1034 |
T1033 |
arg2Of |
inflammation,Controlled |
| R816 |
T1034 |
T1035 |
arg1Of |
inflammation,is |
| R817 |
T1034 |
T1036 |
arg1Of |
inflammation,important |
| R818 |
T1035 |
T1041 |
arg1Of |
is,but |
| R819 |
T1036 |
T1035 |
arg2Of |
important,is |
| R820 |
T1036 |
T1037 |
arg1Of |
important,for |
| R821 |
T1038 |
T1037 |
arg2Of |
fighting,for |
| R822 |
T1039 |
T1038 |
arg2Of |
infection,fighting |
| R823 |
T1041 |
T1040 |
arg1Of |
but,"," |
| R824 |
T1043 |
T1042 |
arg2Of |
excess,in |
| R825 |
T1045 |
T1046 |
arg1Of |
it,becomes |
| R826 |
T1045 |
T1047 |
arg1Of |
it,destructive |
| R827 |
T1046 |
T1041 |
arg2Of |
becomes,but |
| R828 |
T1046 |
T1042 |
arg1Of |
becomes,in |
| R829 |
T1046 |
T1044 |
arg1Of |
becomes,"," |
| R830 |
T1046 |
T1061 |
arg1Of |
becomes,"," |
| R831 |
T1046 |
T1062 |
arg1Of |
becomes,[ |
| R832 |
T1047 |
T1046 |
arg2Of |
destructive,becomes |
| R833 |
T1047 |
T1048 |
arg1Of |
destructive,to |
| R834 |
T1047 |
T1052 |
arg1Of |
destructive,to |
| R835 |
T1048 |
T1051 |
arg1Of |
to,and |
| R836 |
T1050 |
T1048 |
arg2Of |
cells,to |
| R837 |
T1050 |
T1049 |
arg1Of |
cells,host |
| R838 |
T1052 |
T1051 |
arg2Of |
to,and |
| R839 |
T1054 |
T1052 |
arg2Of |
architecture,to |
| R840 |
T1054 |
T1053 |
arg1Of |
architecture,the |
| R841 |
T1054 |
T1055 |
arg1Of |
architecture,of |
| R842 |
T1057 |
T1055 |
arg2Of |
lungs,of |
| R843 |
T1057 |
T1056 |
arg1Of |
lungs,the |
| R844 |
T1057 |
T1058 |
arg1Of |
lungs,[ |
| R845 |
T1059 |
T1058 |
arg2Of |
2,[ |
| R846 |
T1060 |
T1058 |
arg3Of |
],[ |
| R847 |
T1063 |
T1062 |
arg2Of |
3,[ |
| R848 |
T1064 |
T1062 |
arg3Of |
],[ |
| R849 |
T1066 |
T1065 |
arg2Of |
CF,In |
| R850 |
T1070 |
T1068 |
arg1Of |
cells,airway |
| R851 |
T1070 |
T1069 |
arg1Of |
cells,epithelial |
| R852 |
T1070 |
T1071 |
arg1Of |
cells,have |
| R853 |
T1070 |
T1072 |
arg1Of |
cells,been |
| R854 |
T1070 |
T1073 |
arg2Of |
cells,shown |
| R855 |
T1070 |
T1075 |
arg1Of |
cells,produce |
| R856 |
T1073 |
T1065 |
arg1Of |
shown,In |
| R857 |
T1073 |
T1067 |
arg1Of |
shown,"," |
| R858 |
T1073 |
T1071 |
arg2Of |
shown,have |
| R859 |
T1073 |
T1072 |
arg2Of |
shown,been |
| R860 |
T1075 |
T1073 |
arg3Of |
produce,shown |
| R861 |
T1075 |
T1074 |
arg1Of |
produce,to |
| R862 |
T1075 |
T1086 |
arg1Of |
produce,"," |
| R863 |
T1075 |
T1087 |
arg1Of |
produce,[ |
| R864 |
T1080 |
T1075 |
arg2Of |
response,produce |
| R865 |
T1080 |
T1076 |
arg1Of |
response,an |
| R866 |
T1080 |
T1077 |
arg1Of |
response,exaggerated |
| R867 |
T1080 |
T1078 |
arg1Of |
response,pro-inflammatory |
| R868 |
T1080 |
T1079 |
arg1Of |
response,cytokine |
| R869 |
T1080 |
T1081 |
arg1Of |
response,to |
| R870 |
T1082 |
T1081 |
arg2Of |
stimulation,to |
| R871 |
T1082 |
T1083 |
arg1Of |
stimulation,[ |
| R872 |
T1084 |
T1083 |
arg2Of |
4,[ |
| R873 |
T1085 |
T1083 |
arg3Of |
],[ |
| R874 |
T1088 |
T1087 |
arg2Of |
5,[ |
| R875 |
T1089 |
T1087 |
arg3Of |
],[ |
| R876 |
T1092 |
T1091 |
arg2Of |
unclear,is |
| R877 |
T1097 |
T1094 |
arg1Of |
response,this |
| R878 |
T1097 |
T1095 |
arg2Of |
response,heightened |
| R879 |
T1097 |
T1096 |
arg1Of |
response,inflammatory |
| R880 |
T1097 |
T1098 |
arg1Of |
response,is |
| R881 |
T1097 |
T1099 |
arg1Of |
response,intrinsic |
| R882 |
T1098 |
T1093 |
arg1Of |
is,whether |
| R883 |
T1098 |
T1104 |
arg1Of |
is,or |
| R884 |
T1099 |
T1098 |
arg2Of |
intrinsic,is |
| R885 |
T1099 |
T1100 |
arg1Of |
intrinsic,to |
| R886 |
T1101 |
T1100 |
arg2Of |
cells,to |
| R887 |
T1101 |
T1102 |
arg1Of |
cells,lacking |
| R888 |
T1103 |
T1102 |
arg2Of |
CFTR,lacking |
| R889 |
T1104 |
T1090 |
arg1Of |
or,It |
| R890 |
T1104 |
T1091 |
arg1Of |
or,is |
| R891 |
T1104 |
T1092 |
arg1Of |
or,unclear |
| R892 |
T1105 |
T1104 |
arg2Of |
whether,or |
| R893 |
T1106 |
T1107 |
arg1Of |
it,is |
| R894 |
T1107 |
T1105 |
arg2Of |
is,whether |
| R895 |
T1109 |
T1107 |
arg2Of |
result,is |
| R896 |
T1109 |
T1108 |
arg1Of |
result,a |
| R897 |
T1109 |
T1110 |
arg1Of |
result,of |
| R898 |
T1113 |
T1110 |
arg2Of |
infection,of |
| R899 |
T1113 |
T1111 |
arg1Of |
infection,chronic |
| R900 |
T1113 |
T1112 |
arg1Of |
infection,polymicrobial |
| R901 |
T1113 |
T1114 |
arg1Of |
infection,[ |
| R902 |
T1113 |
T1117 |
arg1Of |
infection,"," |
| R903 |
T1113 |
T1118 |
arg1Of |
infection,[ |
| R904 |
T1115 |
T1114 |
arg2Of |
6,[ |
| R905 |
T1116 |
T1114 |
arg3Of |
],[ |
| R906 |
T1119 |
T1118 |
arg2Of |
7,[ |
| R907 |
T1120 |
T1118 |
arg3Of |
],[ |
| R908 |
T1121 |
T1122 |
arg1Of |
Regardless,of |
| R909 |
T1124 |
T1122 |
arg2Of |
controversy,of |
| R910 |
T1124 |
T1123 |
arg1Of |
controversy,this |
| R911 |
T1126 |
T1127 |
arg1Of |
identifying,and |
| R912 |
T1127 |
T1121 |
arg1Of |
and,Regardless |
| R913 |
T1127 |
T1125 |
arg1Of |
and,"," |
| R914 |
T1127 |
T1132 |
arg2Of |
and,is |
| R915 |
T1128 |
T1127 |
arg2Of |
targeting,and |
| R916 |
T1131 |
T1126 |
arg2Of |
mediators,identifying |
| R917 |
T1131 |
T1128 |
arg2Of |
mediators,targeting |
| R918 |
T1131 |
T1129 |
arg1Of |
mediators,relevant |
| R919 |
T1131 |
T1130 |
arg1Of |
mediators,inflammatory |
| R920 |
T1135 |
T1126 |
arg1Of |
step,identifying |
| R921 |
T1135 |
T1128 |
arg1Of |
step,targeting |
| R922 |
T1135 |
T1132 |
arg1Of |
step,is |
| R923 |
T1135 |
T1133 |
arg1Of |
step,a |
| R924 |
T1135 |
T1134 |
arg1Of |
step,critical |
| R925 |
T1135 |
T1136 |
arg1Of |
step,in |
| R926 |
T1137 |
T1136 |
arg2Of |
developing,in |
| R927 |
T1137 |
T1142 |
modOf |
developing,to |
| R928 |
T1137 |
T1149 |
arg1Of |
developing,in |
| R929 |
T1137 |
T1151 |
arg1Of |
developing,[ |
| R930 |
T1140 |
T1139 |
arg1Of |
therapeutic,specific |
| R931 |
T1141 |
T1137 |
arg2Of |
approaches,developing |
| R932 |
T1141 |
T1138 |
arg1Of |
approaches,more |
| R933 |
T1141 |
T1140 |
arg1Of |
approaches,therapeutic |
| R934 |
T1143 |
T1145 |
arg1Of |
control,and |
| R935 |
T1144 |
T1143 |
arg2Of |
inflammation,control |
| R936 |
T1145 |
T1142 |
arg1Of |
and,to |
| R937 |
T1146 |
T1145 |
arg2Of |
improve,and |
| R938 |
T1148 |
T1146 |
arg2Of |
outcomes,improve |
| R939 |
T1148 |
T1147 |
arg1Of |
outcomes,health |
| R940 |
T1150 |
T1149 |
arg2Of |
CF,in |
| R941 |
T1152 |
T1151 |
arg2Of |
8,[ |
| R942 |
T1153 |
T1151 |
arg3Of |
],[ |
| R943 |
T1155 |
T1154 |
arg1Of |
beta,Interleukin-1 |
| R944 |
T1155 |
T1156 |
arg1Of |
beta,( |
| R945 |
T1155 |
T1159 |
arg1Of |
beta,is |
| R946 |
T1157 |
T1156 |
arg2Of |
IL-1β,( |
| R947 |
T1158 |
T1156 |
arg3Of |
),( |
| R948 |
T1163 |
T1159 |
arg2Of |
mediator,is |
| R949 |
T1163 |
T1160 |
arg1Of |
mediator,a |
| R950 |
T1163 |
T1161 |
arg1Of |
mediator,major |
| R951 |
T1163 |
T1162 |
arg1Of |
mediator,inflammatory |
| R952 |
T1166 |
T1164 |
arg1Of |
effects,Its |
| R953 |
T1166 |
T1165 |
arg1Of |
effects,physiological |
| R954 |
T1166 |
T1167 |
arg1Of |
effects,are |
| R955 |
T1166 |
T1168 |
arg1Of |
effects,diverse |
| R956 |
T1166 |
T1171 |
arg1Of |
effects,important |
| R957 |
T1168 |
T1169 |
arg1Of |
diverse,and |
| R958 |
T1169 |
T1167 |
arg2Of |
and,are |
| R959 |
T1171 |
T1169 |
arg2Of |
important,and |
| R960 |
T1171 |
T1170 |
arg1Of |
important,potentially |
| R961 |
T1171 |
T1172 |
arg1Of |
important,to |
| R962 |
T1174 |
T1172 |
arg2Of |
pathogenesis,to |
| R963 |
T1174 |
T1173 |
arg1Of |
pathogenesis,the |
| R964 |
T1174 |
T1175 |
arg1Of |
pathogenesis,of |
| R965 |
T1177 |
T1175 |
arg2Of |
exacerbations,of |
| R966 |
T1177 |
T1176 |
arg1Of |
exacerbations,lung |
| R967 |
T1177 |
T1178 |
arg1Of |
exacerbations,in |
| R968 |
T1177 |
T1180 |
arg1Of |
exacerbations,"," |
| R969 |
T1177 |
T1181 |
arg1Of |
exacerbations,including |
| R970 |
T1179 |
T1178 |
arg2Of |
CF,in |
| R971 |
T1183 |
T1182 |
arg1Of |
generation,the |
| R972 |
T1183 |
T1184 |
arg1Of |
generation,of |
| R973 |
T1183 |
T1186 |
arg1Of |
generation,"," |
| R974 |
T1183 |
T1193 |
arg1Of |
generation,"," |
| R975 |
T1185 |
T1184 |
arg2Of |
fever,of |
| R976 |
T1188 |
T1186 |
arg2Of |
recruitment,"," |
| R977 |
T1188 |
T1187 |
arg1Of |
recruitment,the |
| R978 |
T1188 |
T1189 |
arg1Of |
recruitment,of |
| R979 |
T1192 |
T1189 |
arg2Of |
cells,of |
| R980 |
T1192 |
T1190 |
arg1Of |
cells,inflammatory |
| R981 |
T1192 |
T1191 |
arg1Of |
cells,effector |
| R982 |
T1193 |
T1206 |
arg1Of |
",",and |
| R983 |
T1195 |
T1193 |
arg2Of |
induction,"," |
| R984 |
T1195 |
T1194 |
arg1Of |
induction,the |
| R985 |
T1195 |
T1196 |
arg1Of |
induction,of |
| R986 |
T1199 |
T1196 |
arg2Of |
cytokines,of |
| R987 |
T1199 |
T1197 |
arg1Of |
cytokines,other |
| R988 |
T1199 |
T1198 |
arg1Of |
cytokines,pro-inflammatory |
| R989 |
T1199 |
T1201 |
arg1Of |
cytokines,as |
| R990 |
T1201 |
T1200 |
arg1Of |
as,such |
| R991 |
T1202 |
T1203 |
arg1Of |
IL-6,and |
| R992 |
T1203 |
T1201 |
arg2Of |
and,as |
| R993 |
T1204 |
T1203 |
arg2Of |
IL-8,and |
| R994 |
T1206 |
T1181 |
arg2Of |
and,including |
| R995 |
T1206 |
T1205 |
arg1Of |
and,"," |
| R996 |
T1208 |
T1206 |
arg2Of |
shaping,and |
| R997 |
T1208 |
T1207 |
arg1Of |
shaping,the |
| R998 |
T1208 |
T1209 |
arg1Of |
shaping,of |
| R999 |
T1212 |
T1209 |
arg2Of |
responses,of |
