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PMC:3342329 / 21382-23408 JSONTXT 25 Projects

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Id Subject Object Predicate Lexical cue
T9810 0-8 JJ denotes Numerous
T9811 9-16 NN denotes studies
T9812 17-23 VB denotes showed
T9813 24-28 IN denotes that
T9814 29-37 NN denotes cytokine
T9815 38-44 VB denotes affect
T9816 45-50 NN denotes tumor
T9817 51-57 NN denotes growth
T9818 58-60 IN denotes by
T9819 61-71 VB denotes regulating
T9820 72-77 NN denotes NF-κB
T9821 79-91 JJ denotes Inflammatory
T9822 92-101 NN denotes cytokines
T9823 101-102 -COMMA- denotes ,
T9824 103-112 VB denotes including
T9825 113-117 NN denotes IL-1
T9826 117-118 -COMMA- denotes ,
T9827 119-123 NN denotes IL-6
T9828 124-127 CC denotes and
T9829 128-132 NN denotes IL-8
T9830 132-133 -COMMA- denotes ,
T9831 134-142 VB denotes activate
T9832 143-148 NN denotes NF-κB
T9833 149-157 NN denotes pathways
T9834 158-160 IN denotes in
T9835 161-166 NN denotes tumor
T9836 167-172 NN denotes cells
T9837 173-174 -LRB- denotes [
T9838 174-176 CD denotes 41
T9839 176-177 -RRB- denotes ]
T9840 179-182 DT denotes The
T9841 183-194 NN denotes interleukin
T9842 195-197 CD denotes 10
T9843 198-199 -LRB- denotes (
T9844 199-204 NN denotes IL-10
T9845 204-205 -RRB- denotes )
T9846 206-208 VB denotes is
T9847 209-213 RB denotes well
T9848 214-219 VB denotes known
T9849 220-222 IN denotes as
T9850 223-225 DT denotes an
T9851 226-236 JJ denotes anti-tumor
T9852 237-243 NN denotes factor
T9853 244-246 RB denotes as
T9854 247-251 RB denotes well
T9855 252-254 IN denotes as
T9856 255-257 DT denotes an
T9857 258-275 JJ denotes anti-inflammatory
T9858 276-282 NN denotes factor
T9859 283-284 -LRB- denotes [
T9860 284-286 CD denotes 42
T9861 286-287 -RRB- denotes ]
T9862 287-288 -COMMA- denotes ,
T9863 289-290 -LRB- denotes [
T9864 290-292 CD denotes 43
T9865 292-293 -RRB- denotes ]
T9866 295-300 NN denotes IL-10
T9867 301-309 VB denotes inhibits
T9868 310-324 RB denotes constitutively
T9869 325-334 VB denotes activated
T9870 335-340 NN denotes NF-κB
T9871 341-345 CC denotes both
T9872 346-348 FW denotes in
T9873 349-354 FW denotes vitro
T9874 355-356 -LRB- denotes [
T9875 356-358 CD denotes 44
T9876 358-359 -RRB- denotes ]
T9877 360-363 CC denotes and
T9878 364-366 FW denotes in
T9879 367-371 FW denotes vivo
T9880 372-373 -LRB- denotes [
T9881 373-375 CD denotes 45
T9882 375-376 -RRB- denotes ]
T9883 378-388 NN denotes Inhibition
T9884 389-391 IN denotes of
T9885 392-397 NN denotes NF-κB
T9886 398-400 IN denotes by
T9887 401-404 DT denotes the
T9888 405-410 NN denotes IL-10
T9889 411-422 VB denotes contributes
T9890 423-425 TO denotes to
T9891 426-429 DT denotes the
T9892 430-440 JJ denotes anti-tumor
T9893 441-448 NN denotes effects
T9894 449-456 IN denotes through
T9895 457-460 DT denotes the
T9896 461-471 NN denotes activation
T9897 472-474 IN denotes of
T9898 475-484 NN denotes caspase-3
T9899 485-488 CC denotes and
T9900 489-498 NN denotes apoptosis
T9901 499-501 IN denotes in
T9902 502-517 JJ denotes Colon26-bearing
T9903 518-522 NN denotes mice
T9904 523-524 -LRB- denotes [
T9905 524-526 CD denotes 43
T9906 526-527 -RRB- denotes ]
T9907 529-538 RB denotes Similarly
T9908 538-539 -COMMA- denotes ,
T9909 540-547 JJ denotes several
T9910 548-555 NN denotes studies
T9911 556-560 VB denotes have
T9912 561-573 VB denotes demonstrated
T9913 574-577 DT denotes the
T9914 578-585 NN denotes ability
T9915 586-588 IN denotes of
T9916 589-595 NN denotes IL-1Ra
T9917 596-598 TO denotes to
T9918 599-607 VB denotes abrogate
T9919 608-611 DT denotes the
T9920 612-627 JJ denotes proinflammatory
T9921 628-635 NN denotes effects
T9922 636-638 IN denotes of
T9923 639-643 NN denotes IL-1
T9924 644-645 -LRB- denotes [
T9925 645-647 CD denotes 46
T9926 647-648 -RRB- denotes ]
T9927 650-652 PRP denotes It
T9928 653-656 VB denotes has
T9929 657-661 VB denotes been
T9930 662-670 VB denotes reported
T9931 671-675 IN denotes that
T9932 676-680 NN denotes IL-1
T9933 681-688 VB denotes induces
T9934 689-692 DT denotes the
T9935 693-703 NN denotes activation
T9936 704-706 IN denotes of
T9937 707-712 NN denotes NF-κB
T9938 713-715 IN denotes in
T9939 716-723 JJ denotes several
T9940 724-731 NN denotes cancers
T9941 731-732 -COMMA- denotes ,
T9942 733-736 CC denotes and
T9943 737-746 VB denotes increases
T9944 747-751 NN denotes cell
T9945 752-757 NN denotes cycle
T9946 758-769 NN denotes progression
T9947 769-770 -COMMA- denotes ,
T9948 771-774 CC denotes and
T9949 775-778 DT denotes the
T9950 779-790 NN denotes suppression
T9951 791-793 IN denotes of
T9952 794-803 JJ denotes apoptotic
T9953 804-808 NN denotes cell
T9954 809-814 NN denotes death
T9955 815-822 VB denotes leading
T9956 823-825 TO denotes to
T9957 826-831 NN denotes tumor
T9958 832-841 NN denotes promotion
T9959 843-846 DT denotes The
T9960 847-854 NN denotes results
T9961 855-857 IN denotes of
T9962 858-865 JJ denotes various
T9963 866-873 NN denotes studies
T9964 874-878 IN denotes over
T9965 879-882 DT denotes the
T9966 883-887 JJ denotes past
T9967 888-890 CD denotes 10
T9968 891-896 NN denotes years
T9969 897-905 VB denotes indicate
T9970 906-910 IN denotes that
T9971 911-914 DT denotes the
T9972 915-920 JJ denotes major
T9973 921-929 NN denotes function
T9974 930-932 IN denotes of
T9975 933-939 NN denotes IL-1Ra
T9976 940-942 VB denotes is
T9977 943-945 TO denotes to
T9978 946-954 VB denotes regulate
T9979 955-958 DT denotes the
T9980 959-970 JJ denotes pleiotropic
T9981 971-978 NN denotes effects
T9982 979-981 IN denotes of
T9983 982-986 NN denotes IL-1
T9984 987-989 IN denotes by
T9985 990-1003 RB denotes competitively
T9986 1004-1012 VB denotes blocking
T9987 1013-1016 PRP-DOLLAR- denotes its
T9988 1017-1026 NN denotes functions
T9989 1027-1028 -LRB- denotes [
T9990 1028-1030 CD denotes 47
T9991 1030-1031 -RRB- denotes ]
T9992 1033-1036 DT denotes The
T9993 1037-1044 NN denotes ability
T9994 1045-1047 IN denotes of
T9995 1048-1052 NN denotes IL-1
T9996 1053-1055 TO denotes to
T9997 1056-1062 VB denotes induce
T9998 1063-1066 PRP-DOLLAR- denotes its
T9999 1067-1070 JJ denotes own
T10000 1071-1081 NN denotes antagonist
T10001 1082-1084 VB denotes is
T10002 1085-1087 IN denotes of
T10003 1088-1096 NN denotes interest
T10004 1097-1099 IN denotes in
T10005 1100-1113 VB denotes understanding
T10006 1114-1117 DT denotes the
T10007 1118-1128 NN denotes regulation
T10008 1129-1132 CC denotes and
T10009 1133-1146 NN denotes dysregulation
T10010 1147-1149 IN denotes of
T10011 1150-1154 NN denotes IL-1
T10012 1155-1164 NN denotes signaling
T10013 1165-1167 IN denotes in
T10014 1168-1174 JJ denotes normal
T10015 1175-1178 CC denotes and
T10016 1179-1187 JJ denotes diseased
T10017 1188-1194 NN denotes tissue
T10018 1196-1209 NN denotes Up-regulation
T10019 1210-1212 IN denotes of
T10020 1213-1216 DT denotes the
T10021 1217-1225 NN denotes receptor
T10022 1226-1236 NN denotes antagonist
T10023 1237-1247 VB denotes represents
T10024 1248-1249 DT denotes a
T10025 1250-1259 NN denotes mechanism
T10026 1260-1263 IN denotes for
T10027 1264-1271 VB denotes turning
T10028 1272-1275 RP denotes off
T10029 1276-1280 NN denotes IL-1
T10030 1281-1290 NN denotes signaling
T10031 1291-1294 CC denotes and
T10032 1295-1303 VB denotes creating
T10033 1304-1305 DT denotes a
T10034 1306-1315 JJ denotes temporary
T10035 1316-1321 NN denotes state
T10036 1322-1324 IN denotes of
T10037 1325-1339 NN denotes refractoriness
T10038 1341-1344 DT denotes The
T10039 1345-1353 VB denotes elevated
T10040 1354-1364 NN denotes expression
T10041 1365-1367 IN denotes of
T10042 1368-1374 NN denotes IL-1Ra
T10043 1374-1375 -COMMA- denotes ,
T10044 1376-1383 IN denotes without
T10045 1384-1387 DT denotes any
T10046 1388-1394 NN denotes change
T10047 1395-1397 IN denotes of
T10048 1398-1402 NN denotes IL-1
T10049 1403-1405 IN denotes in
T10050 1406-1412 NN denotes tumors
T10051 1412-1413 -COMMA- denotes ,
T10052 1414-1422 VB denotes suggests
T10053 1423-1427 IN denotes that
T10054 1428-1431 DT denotes the
T10055 1432-1446 JJ denotes IL-1-signaling
T10056 1447-1453 NN denotes system
T10057 1454-1457 MD denotes may
T10058 1458-1460 VB denotes be
T10059 1461-1473 VB denotes dysregulated
T10060 1474-1476 IN denotes by
T10061 1477-1483 NN denotes IL-1Ra
T10062 1484-1486 IN denotes in
T10063 1487-1493 NN denotes tumors
T10064 1495-1501 NN denotes IL-1Ra
T10065 1502-1505 VB denotes has
T10066 1506-1510 VB denotes been
T10067 1511-1516 VB denotes shown
T10068 1517-1519 TO denotes to
T10069 1520-1527 VB denotes inhibit
T10070 1528-1533 NN denotes tumor
T10071 1534-1545 NN denotes progression
T10072 1546-1548 IN denotes in
T10073 1549-1557 NN denotes prostate
T10074 1557-1558 -COMMA- denotes ,
T10075 1559-1565 NN denotes breast
T10076 1565-1566 -COMMA- denotes ,
T10077 1567-1570 CC denotes and
T10078 1571-1575 NN denotes skin
T10079 1576-1582 NN denotes cancer
T10080 1583-1584 -LRB- denotes [
T10081 1584-1586 CD denotes 14
T10082 1586-1587 -RRB- denotes ]
T10083 1587-1588 -COMMA- denotes ,
T10084 1589-1590 -LRB- denotes [
T10085 1590-1592 CD denotes 15
T10086 1592-1593 -RRB- denotes ]
T10087 1593-1594 -COMMA- denotes ,
T10088 1595-1596 -LRB- denotes [
T10089 1596-1598 CD denotes 16
T10090 1598-1599 -RRB- denotes ]
T10091 1601-1614 JJ denotes Intracellular
T10092 1615-1621 NN denotes IL-1Ra
T10093 1622-1623 -LRB- denotes (
T10094 1623-1631 NN denotes icIL-1Ra
T10095 1631-1632 -RRB- denotes )
T10096 1633-1641 VB denotes inhibits
T10097 1642-1646 NN denotes IL-6
T10098 1647-1650 CC denotes and
T10099 1651-1655 NN denotes IL-8
T10100 1656-1666 NN denotes production
T10101 1667-1669 IN denotes in
T10102 1670-1676 NN denotes Caco-2
T10103 1677-1682 NN denotes cells
T10104 1683-1685 IN denotes by
T10105 1686-1694 VB denotes blocking
T10106 1695-1700 NN denotes NF-κB
T10107 1701-1709 NN denotes pathways
T10108 1710-1711 -LRB- denotes [
T10109 1711-1713 CD denotes 37
T10110 1713-1714 -RRB- denotes ]
T10111 1716-1718 PRP denotes We
T10112 1719-1724 VB denotes found
T10113 1725-1729 IN denotes that
T10114 1730-1733 DT denotes the
T10115 1734-1740 NN denotes levels
T10116 1741-1743 IN denotes of
T10117 1744-1750 NN denotes IL-1Ra
T10118 1751-1755 VB denotes were
T10119 1756-1769 RB denotes significantly
T10120 1770-1778 VB denotes elevated
T10121 1779-1781 IN denotes in
T10122 1782-1785 DT denotes the
T10123 1786-1791 NN denotes tumor
T10124 1792-1799 NN denotes tissues
T10125 1800-1802 IN denotes of
T10126 1803-1810 NN denotes CCR5−/−
T10127 1811-1815 NN denotes mice
T10128 1816-1826 VB denotes inoculated
T10129 1827-1831 IN denotes with
T10130 1832-1835 NN denotes B16
T10131 1836-1844 NN denotes melanoma
T10132 1845-1850 NN denotes cells
T10133 1852-1857 VB denotes Taken
T10134 1858-1866 RB denotes together
T10135 1866-1867 -COMMA- denotes ,
T10136 1868-1873 DT denotes these
T10137 1874-1878 NN denotes data
T10138 1879-1887 VB denotes indicate
T10139 1888-1894 NN denotes IL-1Ra
T10140 1895-1900 MD denotes could
T10141 1901-1903 VB denotes be
T10142 1904-1914 RB denotes critically
T10143 1915-1923 VB denotes involved
T10144 1924-1926 IN denotes in
T10145 1927-1930 DT denotes the
T10146 1931-1936 NN denotes tumor
T10147 1937-1943 NN denotes growth
T10148 1944-1954 NN denotes inhibition
T10149 1955-1957 IN denotes of
T10150 1958-1965 NN denotes CCR5−/−
T10151 1966-1970 NN denotes mice
T10152 1971-1978 IN denotes through
T10153 1979-1982 DT denotes the
T10154 1983-1995 NN denotes inactivation
T10155 1996-1998 IN denotes of
T10156 1999-2004 NN denotes NF-κB
T10157 2005-2007 IN denotes in
T10158 2008-2011 DT denotes the
T10159 2012-2019 JJ denotes present
T10160 2020-2025 NN denotes study
R6366 T9811 T9810 arg1Of studies,Numerous
R6367 T9811 T9812 arg1Of studies,showed
R6368 T9814 T9815 arg1Of cytokine,affect
R6369 T9814 T9819 arg1Of cytokine,regulating
R6370 T9815 T9812 arg2Of affect,showed
R6371 T9815 T9813 arg1Of affect,that
R6372 T9815 T9818 arg1Of affect,by
R6373 T9817 T9815 arg2Of growth,affect
R6374 T9817 T9816 arg1Of growth,tumor
R6375 T9819 T9818 arg2Of regulating,by
R6376 T9820 T9819 arg2Of NF-κB,regulating
R6377 T9822 T9821 arg1Of cytokines,Inflammatory
R6378 T9822 T9823 arg1Of cytokines,","
R6379 T9822 T9824 arg1Of cytokines,including
R6380 T9822 T9831 arg1Of cytokines,activate
R6381 T9825 T9826 arg1Of IL-1,","
R6382 T9826 T9828 arg1Of ",",and
R6383 T9827 T9826 arg2Of IL-6,","
R6384 T9828 T9824 arg2Of and,including
R6385 T9829 T9828 arg2Of IL-8,and
R6386 T9831 T9830 arg1Of activate,","
R6387 T9833 T9831 arg2Of pathways,activate
R6388 T9833 T9832 arg1Of pathways,NF-κB
R6389 T9833 T9834 arg1Of pathways,in
R6390 T9836 T9834 arg2Of cells,in
R6391 T9836 T9835 arg1Of cells,tumor
R6392 T9836 T9837 arg1Of cells,[
R6393 T9838 T9837 arg2Of 41,[
R6394 T9839 T9837 arg3Of ],[
R6395 T9841 T9840 arg1Of interleukin,The
R6396 T9841 T9842 arg1Of interleukin,10
R6397 T9841 T9843 arg1Of interleukin,(
R6398 T9841 T9846 arg1Of interleukin,is
R6399 T9841 T9848 arg2Of interleukin,known
R6400 T9844 T9843 arg2Of IL-10,(
R6401 T9845 T9843 arg3Of ),(
R6402 T9848 T9846 arg2Of known,is
R6403 T9848 T9847 arg1Of known,well
R6404 T9848 T9849 arg1Of known,as
R6405 T9848 T9862 arg1Of known,","
R6406 T9848 T9863 arg1Of known,[
R6407 T9852 T9850 arg1Of factor,an
R6408 T9852 T9851 arg1Of factor,anti-tumor
R6409 T9852 T9855 arg1Of factor,as
R6410 T9855 T9849 arg2Of as,as
R6411 T9855 T9853 arg1Of as,as
R6412 T9855 T9854 arg1Of as,well
R6413 T9858 T9855 arg2Of factor,as
R6414 T9858 T9856 arg1Of factor,an
R6415 T9858 T9857 arg1Of factor,anti-inflammatory
R6416 T9858 T9859 arg1Of factor,[
R6417 T9860 T9859 arg2Of 42,[
R6418 T9861 T9859 arg3Of ],[
R6419 T9864 T9863 arg2Of 43,[
R6420 T9865 T9863 arg3Of ],[
R6421 T9866 T9867 arg1Of IL-10,inhibits
R6422 T9867 T9868 arg1Of inhibits,constitutively
R6423 T9867 T9880 arg1Of inhibits,[
R6424 T9870 T9867 arg2Of NF-κB,inhibits
R6425 T9870 T9869 arg2Of NF-κB,activated
R6426 T9870 T9873 arg1Of NF-κB,vitro
R6427 T9870 T9874 arg1Of NF-κB,[
R6428 T9870 T9879 arg1Of NF-κB,vivo
R6429 T9873 T9871 arg1Of vitro,both
R6430 T9873 T9872 arg1Of vitro,in
R6431 T9875 T9874 arg2Of 44,[
R6432 T9876 T9874 arg3Of ],[
R6433 T9879 T9877 arg1Of vivo,and
R6434 T9879 T9878 arg1Of vivo,in
R6435 T9881 T9880 arg2Of 45,[
R6436 T9882 T9880 arg3Of ],[
R6437 T9883 T9884 arg1Of Inhibition,of
R6438 T9883 T9886 arg1Of Inhibition,by
R6439 T9883 T9889 arg1Of Inhibition,contributes
R6440 T9885 T9884 arg2Of NF-κB,of
R6441 T9888 T9886 arg2Of IL-10,by
R6442 T9888 T9887 arg1Of IL-10,the
R6443 T9889 T9890 arg1Of contributes,to
R6444 T9889 T9894 arg1Of contributes,through
R6445 T9889 T9904 arg1Of contributes,[
R6446 T9893 T9890 arg2Of effects,to
R6447 T9893 T9891 arg1Of effects,the
R6448 T9893 T9892 arg1Of effects,anti-tumor
R6449 T9896 T9894 arg2Of activation,through
R6450 T9896 T9895 arg1Of activation,the
R6451 T9896 T9897 arg1Of activation,of
R6452 T9896 T9901 arg1Of activation,in
R6453 T9898 T9899 arg1Of caspase-3,and
R6454 T9899 T9897 arg2Of and,of
R6455 T9900 T9899 arg2Of apoptosis,and
R6456 T9903 T9901 arg2Of mice,in
R6457 T9903 T9902 arg1Of mice,Colon26-bearing
R6458 T9905 T9904 arg2Of 43,[
R6459 T9906 T9904 arg3Of ],[
R6460 T9910 T9909 arg1Of studies,several
R6461 T9910 T9911 arg1Of studies,have
R6462 T9910 T9912 arg1Of studies,demonstrated
R6463 T9912 T9907 arg1Of demonstrated,Similarly
R6464 T9912 T9908 arg1Of demonstrated,","
R6465 T9912 T9911 arg2Of demonstrated,have
R6466 T9914 T9912 arg2Of ability,demonstrated
R6467 T9914 T9913 arg1Of ability,the
R6468 T9914 T9915 arg1Of ability,of
R6469 T9914 T9917 modOf ability,to
R6470 T9916 T9915 arg2Of IL-1Ra,of
R6471 T9918 T9917 arg1Of abrogate,to
R6472 T9921 T9918 arg2Of effects,abrogate
R6473 T9921 T9919 arg1Of effects,the
R6474 T9921 T9920 arg1Of effects,proinflammatory
R6475 T9921 T9922 arg1Of effects,of
R6476 T9923 T9922 arg2Of IL-1,of
R6477 T9923 T9924 arg1Of IL-1,[
R6478 T9925 T9924 arg2Of 46,[
R6479 T9926 T9924 arg3Of ],[
R6480 T9927 T9928 arg1Of It,has
R6481 T9927 T9929 arg1Of It,been
R6482 T9927 T9930 arg2Of It,reported
R6483 T9930 T9928 arg2Of reported,has
R6484 T9930 T9929 arg2Of reported,been
R6485 T9932 T9933 arg1Of IL-1,induces
R6486 T9932 T9943 arg1Of IL-1,increases
R6487 T9933 T9938 arg1Of induces,in
R6488 T9933 T9942 arg1Of induces,and
R6489 T9935 T9933 arg2Of activation,induces
R6490 T9935 T9934 arg1Of activation,the
R6491 T9935 T9936 arg1Of activation,of
R6492 T9937 T9936 arg2Of NF-κB,of
R6493 T9940 T9938 arg2Of cancers,in
R6494 T9940 T9939 arg1Of cancers,several
R6495 T9942 T9930 arg3Of and,reported
R6496 T9942 T9931 arg1Of and,that
R6497 T9942 T9941 arg1Of and,","
R6498 T9943 T9942 arg2Of increases,and
R6499 T9946 T9944 arg1Of progression,cell
R6500 T9946 T9945 arg1Of progression,cycle
R6501 T9946 T9948 arg1Of progression,and
R6502 T9948 T9943 arg2Of and,increases
R6503 T9948 T9947 arg1Of and,","
R6504 T9950 T9948 arg2Of suppression,and
R6505 T9950 T9949 arg1Of suppression,the
R6506 T9950 T9951 arg1Of suppression,of
R6507 T9950 T9955 arg1Of suppression,leading
R6508 T9954 T9951 arg2Of death,of
R6509 T9954 T9952 arg1Of death,apoptotic
R6510 T9954 T9953 arg1Of death,cell
R6511 T9955 T9956 arg1Of leading,to
R6512 T9958 T9956 arg2Of promotion,to
R6513 T9958 T9957 arg1Of promotion,tumor
R6514 T9960 T9959 arg1Of results,The
R6515 T9960 T9961 arg1Of results,of
R6516 T9960 T9964 arg1Of results,over
R6517 T9960 T9969 arg1Of results,indicate
R6518 T9963 T9961 arg2Of studies,of
R6519 T9963 T9962 arg1Of studies,various
R6520 T9968 T9964 arg2Of years,over
R6521 T9968 T9965 arg1Of years,the
R6522 T9968 T9966 arg1Of years,past
R6523 T9968 T9967 arg1Of years,10
R6524 T9973 T9971 arg1Of function,the
R6525 T9973 T9972 arg1Of function,major
R6526 T9973 T9974 arg1Of function,of
R6527 T9973 T9976 arg1Of function,is
R6528 T9975 T9974 arg2Of IL-1Ra,of
R6529 T9976 T9969 arg2Of is,indicate
R6530 T9976 T9970 arg1Of is,that
R6531 T9978 T9976 arg2Of regulate,is
R6532 T9978 T9977 arg1Of regulate,to
R6533 T9978 T9984 arg1Of regulate,by
R6534 T9981 T9978 arg2Of effects,regulate
R6535 T9981 T9979 arg1Of effects,the
R6536 T9981 T9980 arg1Of effects,pleiotropic
R6537 T9981 T9982 arg1Of effects,of
R6538 T9983 T9982 arg2Of IL-1,of
R6539 T9986 T9984 arg2Of blocking,by
R6540 T9986 T9985 arg1Of blocking,competitively
R6541 T9988 T9986 arg2Of functions,blocking
R6542 T9988 T9987 arg1Of functions,its
R6543 T9988 T9989 arg1Of functions,[
R6544 T9990 T9989 arg2Of 47,[
R6545 T9991 T9989 arg3Of ],[
R6546 T9993 T9992 arg1Of ability,The
R6547 T9993 T9994 arg1Of ability,of
R6548 T9993 T9996 modOf ability,to
R6549 T9993 T10001 arg1Of ability,is
R6550 T9993 T10002 arg1Of ability,of
R6551 T9995 T9994 arg2Of IL-1,of
R6552 T9997 T9996 arg1Of induce,to
R6553 T10000 T9997 arg2Of antagonist,induce
R6554 T10000 T9998 arg1Of antagonist,its
R6555 T10000 T9999 arg1Of antagonist,own
R6556 T10002 T10001 arg2Of of,is
R6557 T10003 T10002 arg2Of interest,of
R6558 T10003 T10004 arg1Of interest,in
R6559 T10005 T10004 arg2Of understanding,in
R6560 T10007 T10008 arg1Of regulation,and
R6561 T10008 T10005 arg2Of and,understanding
R6562 T10008 T10006 arg1Of and,the
R6563 T10008 T10010 arg1Of and,of
R6564 T10008 T10013 arg1Of and,in
R6565 T10009 T10008 arg2Of dysregulation,and
R6566 T10012 T10010 arg2Of signaling,of
R6567 T10012 T10011 arg1Of signaling,IL-1
R6568 T10014 T10015 arg1Of normal,and
R6569 T10016 T10015 arg2Of diseased,and
R6570 T10017 T10013 arg2Of tissue,in
R6571 T10017 T10014 arg1Of tissue,normal
R6572 T10017 T10016 arg1Of tissue,diseased
R6573 T10018 T10019 arg1Of Up-regulation,of
R6574 T10018 T10023 arg1Of Up-regulation,represents
R6575 T10022 T10019 arg2Of antagonist,of
R6576 T10022 T10020 arg1Of antagonist,the
R6577 T10022 T10021 arg1Of antagonist,receptor
R6578 T10025 T10023 arg2Of mechanism,represents
R6579 T10025 T10024 arg1Of mechanism,a
R6580 T10025 T10026 arg1Of mechanism,for
R6581 T10027 T10028 arg1Of turning,off
R6582 T10027 T10031 arg1Of turning,and
R6583 T10030 T10027 arg2Of signaling,turning
R6584 T10030 T10029 arg1Of signaling,IL-1
R6585 T10031 T10026 arg2Of and,for
R6586 T10032 T10031 arg2Of creating,and
R6587 T10035 T10032 arg2Of state,creating
R6588 T10035 T10033 arg1Of state,a
R6589 T10035 T10034 arg1Of state,temporary
R6590 T10035 T10036 arg1Of state,of
R6591 T10037 T10036 arg2Of refractoriness,of
R6592 T10040 T10038 arg1Of expression,The
R6593 T10040 T10039 arg2Of expression,elevated
R6594 T10040 T10041 arg1Of expression,of
R6595 T10040 T10043 arg1Of expression,","
R6596 T10040 T10044 arg1Of expression,without
R6597 T10040 T10052 arg1Of expression,suggests
R6598 T10042 T10041 arg2Of IL-1Ra,of
R6599 T10046 T10044 arg2Of change,without
R6600 T10046 T10045 arg1Of change,any
R6601 T10046 T10047 arg1Of change,of
R6602 T10046 T10049 arg1Of change,in
R6603 T10048 T10047 arg2Of IL-1,of
R6604 T10050 T10049 arg2Of tumors,in
R6605 T10052 T10051 arg1Of suggests,","
R6606 T10056 T10054 arg1Of system,the
R6607 T10056 T10055 arg1Of system,IL-1-signaling
R6608 T10056 T10057 arg1Of system,may
R6609 T10056 T10058 arg1Of system,be
R6610 T10056 T10059 arg2Of system,dysregulated
R6611 T10059 T10052 arg2Of dysregulated,suggests
R6612 T10059 T10053 arg1Of dysregulated,that
R6613 T10059 T10057 arg2Of dysregulated,may
R6614 T10059 T10058 arg2Of dysregulated,be
R6615 T10059 T10062 arg1Of dysregulated,in
R6616 T10061 T10059 arg1Of IL-1Ra,dysregulated
R6617 T10061 T10060 arg2Of IL-1Ra,by
R6618 T10063 T10062 arg2Of tumors,in
R6619 T10064 T10065 arg1Of IL-1Ra,has
R6620 T10064 T10066 arg1Of IL-1Ra,been
R6621 T10064 T10067 arg2Of IL-1Ra,shown
R6622 T10064 T10069 arg1Of IL-1Ra,inhibit
R6623 T10067 T10065 arg2Of shown,has
R6624 T10067 T10066 arg2Of shown,been
R6625 T10069 T10067 arg3Of inhibit,shown
R6626 T10069 T10068 arg1Of inhibit,to
R6627 T10069 T10080 arg1Of inhibit,[
R6628 T10069 T10083 arg1Of inhibit,","
R6629 T10069 T10084 arg1Of inhibit,[
R6630 T10069 T10087 arg1Of inhibit,","
R6631 T10069 T10088 arg1Of inhibit,[
R6632 T10071 T10069 arg2Of progression,inhibit
R6633 T10071 T10070 arg1Of progression,tumor
R6634 T10071 T10072 arg1Of progression,in
R6635 T10073 T10074 arg1Of prostate,","
R6636 T10074 T10077 arg1Of ",",and
R6637 T10075 T10074 arg2Of breast,","
R6638 T10077 T10072 arg2Of and,in
R6639 T10077 T10076 arg1Of and,","
R6640 T10079 T10077 arg2Of cancer,and
R6641 T10079 T10078 arg1Of cancer,skin
R6642 T10081 T10080 arg2Of 14,[
R6643 T10082 T10080 arg3Of ],[
R6644 T10085 T10084 arg2Of 15,[
R6645 T10086 T10084 arg3Of ],[
R6646 T10089 T10088 arg2Of 16,[
R6647 T10090 T10088 arg3Of ],[
R6648 T10092 T10091 arg1Of IL-1Ra,Intracellular
R6649 T10092 T10093 arg1Of IL-1Ra,(
R6650 T10092 T10096 arg1Of IL-1Ra,inhibits
R6651 T10092 T10105 arg1Of IL-1Ra,blocking
R6652 T10094 T10093 arg2Of icIL-1Ra,(
R6653 T10095 T10093 arg3Of ),(
R6654 T10096 T10104 arg1Of inhibits,by
R6655 T10097 T10098 arg1Of IL-6,and
R6656 T10099 T10098 arg2Of IL-8,and
R6657 T10100 T10096 arg2Of production,inhibits
R6658 T10100 T10097 arg1Of production,IL-6
R6659 T10100 T10099 arg1Of production,IL-8
R6660 T10100 T10101 arg1Of production,in
R6661 T10103 T10101 arg2Of cells,in
R6662 T10103 T10102 arg1Of cells,Caco-2
R6663 T10105 T10104 arg2Of blocking,by
R6664 T10107 T10105 arg2Of pathways,blocking
R6665 T10107 T10106 arg1Of pathways,NF-κB
R6666 T10107 T10108 arg1Of pathways,[
R6667 T10109 T10108 arg2Of 37,[
R6668 T10110 T10108 arg3Of ],[
R6669 T10111 T10112 arg1Of We,found
R6670 T10115 T10114 arg1Of levels,the
R6671 T10115 T10116 arg1Of levels,of
R6672 T10115 T10118 arg1Of levels,were
R6673 T10115 T10120 arg2Of levels,elevated
R6674 T10117 T10116 arg2Of IL-1Ra,of
R6675 T10120 T10112 arg2Of elevated,found
R6676 T10120 T10113 arg1Of elevated,that
R6677 T10120 T10118 arg2Of elevated,were
R6678 T10120 T10119 arg1Of elevated,significantly
R6679 T10120 T10121 arg1Of elevated,in
R6680 T10124 T10121 arg2Of tissues,in
R6681 T10124 T10122 arg1Of tissues,the
R6682 T10124 T10123 arg1Of tissues,tumor
R6683 T10124 T10125 arg1Of tissues,of
R6684 T10127 T10125 arg2Of mice,of
R6685 T10127 T10126 arg1Of mice,CCR5−/−
R6686 T10127 T10128 arg2Of mice,inoculated
R6687 T10128 T10129 arg1Of inoculated,with
R6688 T10132 T10129 arg2Of cells,with
R6689 T10132 T10130 arg1Of cells,B16
R6690 T10132 T10131 arg1Of cells,melanoma
R6691 T10133 T10134 arg1Of Taken,together
R6692 T10137 T10136 arg1Of data,these
R6693 T10137 T10138 arg1Of data,indicate
R6694 T10138 T10133 modOf indicate,Taken
R6695 T10138 T10135 arg1Of indicate,","
R6696 T10139 T10140 arg1Of IL-1Ra,could
R6697 T10139 T10141 arg1Of IL-1Ra,be
R6698 T10139 T10143 arg2Of IL-1Ra,involved
R6699 T10143 T10138 arg2Of involved,indicate
R6700 T10143 T10140 arg2Of involved,could
R6701 T10143 T10141 arg2Of involved,be
R6702 T10143 T10142 arg1Of involved,critically
R6703 T10143 T10144 arg1Of involved,in
R6704 T10143 T10152 arg1Of involved,through
R6705 T10148 T10144 arg2Of inhibition,in
R6706 T10148 T10145 arg1Of inhibition,the
R6707 T10148 T10146 arg1Of inhibition,tumor
R6708 T10148 T10147 arg1Of inhibition,growth
R6709 T10148 T10149 arg1Of inhibition,of
R6710 T10151 T10149 arg2Of mice,of
R6711 T10151 T10150 arg1Of mice,CCR5−/−
R6712 T10154 T10152 arg2Of inactivation,through
R6713 T10154 T10153 arg1Of inactivation,the
R6714 T10154 T10155 arg1Of inactivation,of
R6715 T10154 T10157 arg1Of inactivation,in
R6716 T10156 T10155 arg2Of NF-κB,of
R6717 T10160 T10157 arg2Of study,in
R6718 T10160 T10158 arg1Of study,the
R6719 T10160 T10159 arg1Of study,present