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PMC:3291650 JSONTXT 30 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T69 0-3 NN denotes A20
T70 4-5 -LRB- denotes (
T71 5-12 NN denotes Tnfaip3
T72 12-13 -RRB- denotes )
T73 14-24 NN denotes Deficiency
T74 25-27 IN denotes in
T75 28-35 NNP denotes Myeloid
T76 36-41 NNP denotes Cells
T77 42-50 NNP denotes Protects
T78 51-58 IN denotes against
T79 59-68 NNP denotes Influenza
T80 69-70 NNP denotes A
T81 71-76 NNP denotes Virus
T82 77-86 NNP denotes Infection
T83 147-150 DT denotes The
T84 151-157 JJ denotes innate
T85 158-164 JJ denotes immune
T86 165-173 NN denotes response
T87 174-182 VB denotes provides
T88 183-186 DT denotes the
T89 187-192 JJ denotes first
T90 193-197 NN denotes line
T91 198-200 IN denotes of
T92 201-208 NN denotes defense
T93 209-216 IN denotes against
T94 217-224 NN denotes viruses
T95 225-228 CC denotes and
T96 229-234 JJ denotes other
T97 235-244 NN denotes pathogens
T98 245-247 IN denotes by
T99 248-258 VB denotes responding
T100 259-261 TO denotes to
T101 262-270 JJ denotes specific
T102 271-280 JJ denotes microbial
T103 281-290 NN denotes molecules
T104 292-301 NN denotes Influenza
T105 302-303 NN denotes A
T106 304-309 NN denotes virus
T107 310-311 -LRB- denotes (
T108 311-314 NN denotes IAV
T109 314-315 -RRB- denotes )
T110 316-324 VB denotes produces
T111 325-340 JJ denotes double-stranded
T112 341-344 NN denotes RNA
T113 345-347 IN denotes as
T114 348-350 DT denotes an
T115 351-363 NN denotes intermediate
T116 364-370 IN denotes during
T117 371-374 DT denotes the
T118 375-386 NN denotes replication
T119 387-391 NN denotes life
T120 392-397 NN denotes cycle
T121 397-398 -COMMA- denotes ,
T122 399-404 WDT denotes which
T123 405-414 VB denotes activates
T124 415-418 DT denotes the
T125 419-432 JJ denotes intracellular
T126 433-441 NN denotes pathogen
T127 442-453 NN denotes recognition
T128 454-462 NN denotes receptor
T129 463-468 NN denotes RIG-I
T130 469-472 CC denotes and
T131 473-480 VB denotes induces
T132 481-484 DT denotes the
T133 485-495 NN denotes production
T134 496-498 IN denotes of
T135 499-514 JJ denotes proinflammatory
T136 515-524 NN denotes cytokines
T137 525-528 CC denotes and
T138 529-538 JJ denotes antiviral
T139 539-549 NN denotes interferon
T140 551-564 VB denotes Understanding
T141 565-568 DT denotes the
T142 569-579 NN denotes mechanisms
T143 580-584 WDT denotes that
T144 585-593 VB denotes regulate
T145 594-600 JJ denotes innate
T146 601-607 JJ denotes immune
T147 608-617 NN denotes responses
T148 618-620 TO denotes to
T149 621-624 NN denotes IAV
T150 625-628 CC denotes and
T151 629-634 JJ denotes other
T152 635-642 NN denotes viruses
T153 643-645 VB denotes is
T154 646-648 IN denotes of
T155 649-652 JJ denotes key
T156 653-663 NN denotes importance
T157 664-666 TO denotes to
T158 667-674 VB denotes develop
T159 675-680 JJ denotes novel
T160 681-692 JJ denotes therapeutic
T161 693-703 NN denotes strategies
T162 705-709 RB denotes Here
T163 710-712 PRP denotes we
T164 713-717 VB denotes used
T165 718-725 JJ denotes myeloid
T166 726-730 NN denotes cell
T167 731-739 JJ denotes specific
T168 740-743 NN denotes A20
T169 744-752 NN denotes knockout
T170 753-757 NN denotes mice
T171 758-760 TO denotes to
T172 761-768 VB denotes examine
T173 769-772 DT denotes the
T174 773-777 NN denotes role
T175 778-780 IN denotes of
T176 781-784 DT denotes the
T177 785-802 JJ denotes ubiquitin-editing
T178 803-810 NN denotes protein
T179 811-814 NN denotes A20
T180 815-817 IN denotes in
T181 818-821 DT denotes the
T182 822-830 NN denotes response
T183 831-833 IN denotes of
T184 834-841 JJ denotes myeloid
T185 842-847 NN denotes cells
T186 848-850 TO denotes to
T187 851-854 NN denotes IAV
T188 855-864 NN denotes infection
T189 866-869 NN denotes A20
T190 870-879 JJ denotes deficient
T191 880-891 NN denotes macrophages
T192 892-896 VB denotes were
T193 897-912 JJ denotes hyperresponsive
T194 913-915 TO denotes to
T195 916-922 VB denotes double
T196 923-931 JJ denotes stranded
T197 932-935 NN denotes RNA
T198 936-939 CC denotes and
T199 940-943 NN denotes IAV
T200 944-953 NN denotes infection
T201 953-954 -COMMA- denotes ,
T202 955-957 IN denotes as
T203 958-969 VB denotes illustrated
T204 970-972 IN denotes by
T205 973-981 VB denotes enhanced
T206 982-987 NN denotes NF-κB
T207 988-991 CC denotes and
T208 992-996 NN denotes IRF3
T209 997-1007 NN denotes activation
T210 1007-1008 -COMMA- denotes ,
T211 1009-1020 JJ denotes concomitant
T212 1021-1025 IN denotes with
T213 1026-1035 VB denotes increased
T214 1036-1046 NN denotes production
T215 1047-1049 IN denotes of
T216 1050-1065 JJ denotes proinflammatory
T217 1066-1075 NN denotes cytokines
T218 1075-1076 -COMMA- denotes ,
T219 1077-1087 NN denotes chemokines
T220 1088-1091 CC denotes and
T221 1092-1096 NN denotes type
T222 1097-1098 CD denotes I
T223 1099-1109 NN denotes interferon
T224 1111-1113 FW denotes In
T225 1114-1118 FW denotes vivo
T226 1119-1123 DT denotes this
T227 1124-1127 VB denotes was
T228 1128-1138 VB denotes associated
T229 1139-1143 IN denotes with
T230 1144-1146 DT denotes an
T231 1147-1156 VB denotes increased
T232 1157-1163 NN denotes number
T233 1164-1166 IN denotes of
T234 1167-1175 JJ denotes alveolar
T235 1176-1187 NN denotes macrophages
T236 1188-1191 CC denotes and
T237 1192-1203 NN denotes neutrophils
T238 1204-1206 IN denotes in
T239 1207-1210 DT denotes the
T240 1211-1216 NN denotes lungs
T241 1217-1219 IN denotes of
T242 1220-1223 NN denotes IAV
T243 1224-1232 JJ denotes infected
T244 1233-1237 NN denotes mice
T245 1239-1251 RB denotes Surprisingly
T246 1251-1252 -COMMA- denotes ,
T247 1253-1260 JJ denotes myeloid
T248 1261-1265 NN denotes cell
T249 1266-1274 JJ denotes specific
T250 1275-1278 NN denotes A20
T251 1279-1287 NN denotes knockout
T252 1288-1292 NN denotes mice
T253 1293-1296 VB denotes are
T254 1297-1306 VB denotes protected
T255 1307-1314 IN denotes against
T256 1315-1321 JJ denotes lethal
T257 1322-1325 NN denotes IAV
T258 1326-1335 NN denotes infection
T259 1337-1342 DT denotes These
T260 1343-1350 NN denotes results
T261 1351-1360 VB denotes challenge
T262 1361-1364 DT denotes the
T263 1365-1372 JJ denotes general
T264 1373-1379 NN denotes belief
T265 1380-1384 IN denotes that
T266 1385-1387 DT denotes an
T267 1388-1397 JJ denotes excessive
T268 1398-1402 NN denotes host
T269 1403-1418 JJ denotes proinflammatory
T270 1419-1427 NN denotes response
T271 1428-1430 VB denotes is
T272 1431-1441 VB denotes associated
T273 1442-1446 IN denotes with
T274 1447-1458 JJ denotes IAV-induced
T275 1459-1468 NN denotes lethality
T276 1468-1469 -COMMA- denotes ,
T277 1470-1473 CC denotes and
T278 1474-1481 VB denotes suggest
T279 1482-1486 IN denotes that
T280 1487-1492 IN denotes under
T281 1493-1500 JJ denotes certain
T282 1501-1511 NN denotes conditions
T283 1512-1522 NN denotes inhibition
T284 1523-1525 IN denotes of
T285 1526-1529 NN denotes A20
T286 1530-1535 MD denotes might
T287 1536-1538 VB denotes be
T288 1539-1541 IN denotes of
T289 1542-1550 NN denotes interest
T290 1551-1553 IN denotes in
T291 1554-1557 DT denotes the
T292 1558-1568 NN denotes management
T293 1569-1571 IN denotes of
T294 1572-1575 NN denotes IAV
T295 1576-1586 NN denotes infections
T1339 2871-2878 NN denotes Viruses
T1340 2879-2882 VB denotes are
T1341 2883-2884 DT denotes a
T1342 2885-2890 NN denotes class
T1343 2891-2893 IN denotes of
T1344 2894-2900 RB denotes highly
T1345 2901-2908 JJ denotes diverse
T1346 2909-2918 NN denotes pathogens
T1347 2919-2924 WDT denotes which
T1348 2925-2931 VB denotes depend
T1349 2932-2934 IN denotes on
T1350 2935-2938 DT denotes the
T1351 2939-2943 NN denotes host
T1352 2944-2948 NN denotes cell
T1353 2949-2952 IN denotes for
T1354 2953-2958 PRP-DOLLAR- denotes their
T1355 2959-2970 NN denotes replication
T1356 2972-2975 DT denotes The
T1357 2976-2986 NN denotes initiation
T1358 2987-2989 IN denotes of
T1359 2990-2991 DT denotes a
T1360 2992-3002 JJ denotes protective
T1361 3003-3009 JJ denotes innate
T1362 3010-3019 JJ denotes antiviral
T1363 3020-3026 JJ denotes immune
T1364 3027-3035 NN denotes response
T1365 3036-3044 VB denotes involves
T1366 3045-3048 DT denotes the
T1367 3049-3055 NN denotes action
T1368 3056-3058 IN denotes of
T1369 3059-3070 VB denotes specialized
T1370 3071-3078 NN denotes pattern
T1371 3079-3090 NN denotes recognition
T1372 3091-3100 NN denotes receptors
T1373 3101-3102 -LRB- denotes (
T1374 3102-3105 NN denotes PRR
T1375 3105-3106 -RRB- denotes )
T1376 3106-3107 -COMMA- denotes ,
T1377 3108-3113 WDT denotes which
T1378 3114-3120 VB denotes detect
T1379 3121-3130 VB denotes conserved
T1380 3131-3140 JJ denotes molecular
T1381 3141-3151 NN denotes structures
T1382 3152-3154 IN denotes of
T1383 3155-3158 DT denotes the
T1384 3159-3167 VB denotes invading
T1385 3168-3176 NN denotes pathogen
T1386 3178-3188 NN denotes Triggering
T1387 3189-3191 IN denotes of
T1388 3192-3196 NN denotes PRRs
T1389 3197-3204 VB denotes induces
T1390 3205-3208 DT denotes the
T1391 3209-3219 NN denotes production
T1392 3220-3222 IN denotes of
T1393 3223-3227 NN denotes host
T1394 3228-3243 JJ denotes proinflammatory
T1395 3244-3253 NN denotes cytokines
T1396 3254-3255 -LRB- denotes (
T1397 3255-3259 FW denotes e.g.
T1398 3260-3263 NN denotes TNF
T1399 3263-3264 -COMMA- denotes ,
T1400 3265-3269 NN denotes IL-6
T1401 3270-3273 CC denotes and
T1402 3274-3278 NN denotes IL-1
T1403 3278-3279 -RRB- denotes )
T1404 3280-3283 CC denotes and
T1405 3284-3288 NN denotes type
T1406 3289-3290 CD denotes I
T1407 3291-3302 NN denotes interferons
T1408 3303-3304 -LRB- denotes (
T1409 3304-3316 NN denotes interferon-α
T1410 3317-3318 -LRB- denotes (
T1411 3318-3323 NN denotes IFN-α
T1412 3323-3324 -RRB- denotes )
T1413 3325-3328 CC denotes and
T1414 3329-3334 NN denotes IFN-β
T1415 3334-3335 -RRB- denotes )
T1416 3336-3343 IN denotes through
T1417 3344-3354 NN denotes activation
T1418 3355-3357 IN denotes of
T1419 3358-3368 JJ denotes downstream
T1420 3369-3378 NN denotes signaling
T1421 3379-3387 NN denotes pathways
T1422 3388-3392 WDT denotes that
T1423 3393-3400 VB denotes control
T1424 3401-3408 JJ denotes various
T1425 3409-3422 NN denotes transcription
T1426 3423-3430 NN denotes factors
T1427 3431-3435 JJ denotes such
T1428 3436-3438 IN denotes as
T1429 3439-3444 NN denotes NF-κB
T1430 3444-3445 -COMMA- denotes ,
T1431 3446-3450 NN denotes AP-1
T1432 3450-3451 -COMMA- denotes ,
T1433 3452-3456 NN denotes IRF3
T1434 3457-3460 CC denotes and
T1435 3461-3465 NN denotes IRF7
T1436 3466-3467 -LRB- denotes [
T1437 3467-3468 CD denotes 1
T1438 3468-3469 -RRB- denotes ]
T1439 3469-3470 -COMMA- denotes ,
T1440 3471-3472 -LRB- denotes [
T1441 3472-3473 CD denotes 2
T1442 3473-3474 -RRB- denotes ]
T1443 3476-3479 DT denotes The
T1444 3480-3488 NN denotes presence
T1445 3489-3491 IN denotes of
T1446 3492-3497 JJ denotes viral
T1447 3498-3505 JJ denotes nucleic
T1448 3506-3511 NN denotes acids
T1449 3511-3512 -COMMA- denotes ,
T1450 3513-3517 JJ denotes such
T1451 3518-3520 IN denotes as
T1452 3521-3526 JJ denotes viral
T1453 3527-3530 NN denotes RNA
T1454 3531-3534 CC denotes and
T1455 3535-3538 NN denotes DNA
T1456 3538-3539 -COMMA- denotes ,
T1457 3540-3545 JJ denotes viral
T1458 3546-3557 NN denotes replication
T1459 3558-3571 NN denotes intermediates
T1460 3572-3575 CC denotes and
T1461 3576-3581 JJ denotes viral
T1462 3582-3595 NN denotes transcription
T1463 3596-3604 NN denotes products
T1464 3604-3605 -COMMA- denotes ,
T1465 3606-3609 MD denotes can
T1466 3610-3612 VB denotes be
T1467 3613-3619 VB denotes sensed
T1468 3620-3622 IN denotes by
T1469 3623-3631 JJ denotes specific
T1470 3632-3645 JJ denotes intracellular
T1471 3646-3650 NN denotes PRRs
T1472 3651-3652 -LRB- denotes [
T1473 3652-3653 CD denotes 3
T1474 3653-3654 -RRB- denotes ]
T1475 3656-3665 JJ denotes Endosomal
T1476 3666-3675 JJ denotes Toll-like
T1477 3676-3685 NN denotes receptors
T1478 3686-3687 -LRB- denotes (
T1479 3687-3691 NN denotes TLRs
T1480 3691-3692 -RRB- denotes )
T1481 3693-3696 CC denotes and
T1482 3697-3708 JJ denotes cytoplasmic
T1483 3709-3712 NN denotes RNA
T1484 3713-3721 NN denotes helicase
T1485 3722-3732 JJ denotes RIG-I-like
T1486 3733-3742 NN denotes receptors
T1487 3743-3744 -LRB- denotes (
T1488 3744-3748 NN denotes RLRs
T1489 3748-3749 -RRB- denotes )
T1490 3750-3752 CC denotes or
T1491 3753-3761 JJ denotes Nod-like
T1492 3762-3771 NN denotes receptors
T1493 3772-3773 -LRB- denotes (
T1494 3773-3777 NN denotes NLRs
T1495 3777-3778 -RRB- denotes )
T1496 3779-3785 VB denotes detect
T1497 3786-3789 DT denotes the
T1498 3790-3798 NN denotes presence
T1499 3799-3801 IN denotes of
T1500 3802-3807 JJ denotes viral
T1501 3808-3814 JJ denotes single
T1502 3815-3823 JJ denotes stranded
T1503 3824-3825 -LRB- denotes (
T1504 3825-3829 NN denotes TLR7
T1505 3829-3830 -COMMA- denotes ,
T1506 3831-3835 NN denotes TLR8
T1507 3835-3836 -COMMA- denotes ,
T1508 3837-3841 NN denotes Nod2
T1509 3841-3842 -RRB- denotes )
T1510 3843-3845 CC denotes or
T1511 3846-3852 JJ denotes double
T1512 3853-3861 JJ denotes stranded
T1513 3862-3865 NN denotes RNA
T1514 3866-3867 -LRB- denotes (
T1515 3867-3871 NN denotes TLR3
T1516 3871-3872 -COMMA- denotes ,
T1517 3873-3878 NN denotes RIG-I
T1518 3878-3879 -COMMA- denotes ,
T1519 3880-3884 NN denotes MDA5
T1520 3884-3885 -RRB- denotes )
T1521 3887-3900 JJ denotes Intracellular
T1522 3901-3904 NN denotes DNA
T1523 3905-3912 NN denotes sensors
T1524 3913-3917 WDT denotes that
T1525 3918-3925 VB denotes mediate
T1526 3926-3935 JJ denotes antiviral
T1527 3936-3942 JJ denotes immune
T1528 3943-3952 NN denotes responses
T1529 3953-3955 TO denotes to
T1530 3956-3959 NN denotes DNA
T1531 3960-3967 NN denotes viruses
T1532 3968-3975 VB denotes include
T1533 3976-3980 NN denotes TLR9
T1534 3980-3981 -COMMA- denotes ,
T1535 3982-3985 NNP denotes DAI
T1536 3986-3987 -LRB- denotes [
T1537 3987-3988 CD denotes 4
T1538 3988-3989 -RRB- denotes ]
T1539 3990-3993 CC denotes and
T1540 3994-3997 DT denotes the
T1541 3998-4003 NN denotes PYHIN
T1542 4004-4010 NN denotes domain
T1543 4011-4021 VB denotes containing
T1544 4022-4030 NN denotes proteins
T1545 4031-4035 NN denotes AIM2
T1546 4036-4037 -LRB- denotes [
T1547 4037-4038 CD denotes 5
T1548 4038-4039 -RRB- denotes ]
T1549 4039-4040 -COMMA- denotes ,
T1550 4041-4042 -LRB- denotes [
T1551 4042-4043 CD denotes 6
T1552 4043-4044 -RRB- denotes ]
T1553 4044-4045 -COMMA- denotes ,
T1554 4046-4047 -LRB- denotes [
T1555 4047-4048 CD denotes 7
T1556 4048-4049 -RRB- denotes ]
T1557 4050-4053 CC denotes and
T1558 4054-4059 NN denotes IFI16
T1559 4060-4061 -LRB- denotes [
T1560 4061-4062 CD denotes 8
T1561 4062-4063 -RRB- denotes ]
T1562 4065-4068 NN denotes TLR
T1563 4069-4077 VB denotes mediated
T1564 4078-4087 JJ denotes antiviral
T1565 4088-4097 NN denotes responses
T1566 4098-4101 VB denotes are
T1567 4102-4112 JJ denotes restricted
T1568 4113-4115 TO denotes to
T1569 4116-4127 VB denotes specialized
T1570 4128-4132 NN denotes type
T1571 4133-4134 CD denotes I
T1572 4135-4138 NN denotes IFN
T1573 4139-4148 VB denotes producing
T1574 4149-4161 JJ denotes plasmacytoid
T1575 4162-4171 JJ denotes dendritic
T1576 4172-4177 NN denotes cells
T1577 4178-4179 -LRB- denotes (
T1578 4179-4182 NN denotes pDC
T1579 4182-4183 -RRB- denotes )
T1580 4183-4184 -COMMA- denotes ,
T1581 4185-4190 IN denotes while
T1582 4191-4195 JJ denotes most
T1583 4196-4201 JJ denotes other
T1584 4202-4206 NN denotes cell
T1585 4207-4212 NN denotes types
T1586 4212-4213 -COMMA- denotes ,
T1587 4214-4223 VB denotes including
T1588 4224-4236 JJ denotes conventional
T1589 4237-4239 NN denotes DC
T1590 4240-4241 -LRB- denotes (
T1591 4241-4244 NN denotes cDC
T1592 4244-4245 -RRB- denotes )
T1593 4245-4246 -COMMA- denotes ,
T1594 4247-4258 NN denotes macrophages
T1595 4259-4262 CC denotes and
T1596 4263-4274 NN denotes fibroblasts
T1597 4274-4275 -COMMA- denotes ,
T1598 4276-4282 VB denotes depend
T1599 4283-4285 IN denotes on
T1600 4286-4289 DT denotes the
T1601 4290-4299 JJ denotes cytosolic
T1602 4300-4303 NN denotes RNA
T1603 4304-4307 CC denotes and
T1604 4308-4311 NN denotes DNA
T1605 4312-4319 NN denotes sensors
T1606 4320-4323 IN denotes for
T1607 4324-4327 DT denotes the
T1608 4328-4338 NN denotes production
T1609 4339-4341 IN denotes of
T1610 4342-4351 JJ denotes antiviral
T1611 4352-4360 NN denotes proteins
T1612 4361-4362 -LRB- denotes [
T1613 4362-4363 CD denotes 9
T1614 4363-4364 -RRB- denotes ]
T1615 4366-4375 NN denotes Influenza
T1616 4376-4377 NN denotes A
T1617 4378-4383 NN denotes virus
T1618 4384-4385 -LRB- denotes (
T1619 4385-4388 NN denotes IAV
T1620 4388-4389 -RRB- denotes )
T1621 4390-4392 VB denotes is
T1622 4393-4396 DT denotes the
T1623 4397-4408 JJ denotes etiological
T1624 4409-4414 NN denotes agent
T1625 4415-4417 IN denotes of
T1626 4418-4419 DT denotes a
T1627 4420-4430 JJ denotes contagious
T1628 4431-4436 JJ denotes acute
T1629 4437-4448 JJ denotes respiratory
T1630 4449-4456 NN denotes disease
T1631 4457-4461 WDT denotes that
T1632 4462-4468 VB denotes causes
T1633 4469-4481 JJ denotes considerable
T1634 4482-4491 NN denotes mortality
T1635 4491-4492 -COMMA- denotes ,
T1636 4493-4498 WDT denotes which
T1637 4499-4501 VB denotes is
T1638 4502-4511 RB denotes generally
T1639 4512-4520 VB denotes believed
T1640 4521-4523 TO denotes to
T1641 4524-4526 VB denotes be
T1642 4527-4530 IN denotes due
T1643 4531-4533 TO denotes to
T1644 4534-4536 DT denotes an
T1645 4537-4546 JJ denotes excessive
T1646 4547-4551 NN denotes host
T1647 4552-4564 JJ denotes inflammatory
T1648 4565-4573 NN denotes response
T1649 4575-4584 NN denotes Emergence
T1650 4585-4587 IN denotes of
T1651 4588-4602 JJ denotes drug-resistant
T1652 4603-4610 NN denotes strains
T1653 4611-4613 IN denotes of
T1654 4614-4623 NN denotes influenza
T1655 4624-4631 NN denotes viruses
T1656 4632-4636 IN denotes with
T1657 4637-4645 JJ denotes pandemic
T1658 4646-4655 NN denotes potential
T1659 4656-4667 VB denotes underscores
T1660 4668-4671 DT denotes the
T1661 4672-4682 NN denotes importance
T1662 4683-4685 IN denotes of
T1663 4686-4696 VB denotes developing
T1664 4697-4702 JJ denotes novel
T1665 4703-4712 JJ denotes antiviral
T1666 4713-4723 NN denotes strategies
T1667 4725-4727 IN denotes In
T1668 4728-4732 DT denotes this
T1669 4733-4740 NN denotes context
T1670 4740-4741 -COMMA- denotes ,
T1671 4742-4755 NN denotes understanding
T1672 4756-4758 IN denotes of
T1673 4759-4762 DT denotes the
T1674 4763-4773 NN denotes mechanisms
T1675 4774-4778 WDT denotes that
T1676 4779-4787 VB denotes regulate
T1677 4788-4799 JJ denotes IAV-induced
T1678 4800-4806 JJ denotes immune
T1679 4807-4816 NN denotes responses
T1680 4817-4819 VB denotes is
T1681 4820-4828 JJ denotes critical
T1682 4830-4833 NN denotes IAV
T1683 4834-4843 NN denotes infection
T1684 4844-4849 VB denotes leads
T1685 4850-4852 TO denotes to
T1686 4853-4856 DT denotes the
T1687 4857-4865 NN denotes exposure
T1688 4866-4868 IN denotes in
T1689 4869-4872 DT denotes the
T1690 4873-4877 NN denotes host
T1691 4878-4882 NN denotes cell
T1692 4883-4885 IN denotes of
T1693 4886-4901 JJ denotes single-stranded
T1694 4902-4909 JJ denotes genomic
T1695 4910-4913 NN denotes RNA
T1696 4914-4917 CC denotes and
T1697 4918-4924 JJ denotes double
T1698 4925-4933 JJ denotes stranded
T1699 4934-4937 NN denotes RNA
T1700 4937-4938 -COMMA- denotes ,
T1701 4939-4942 DT denotes the
T1702 4943-4949 JJ denotes latter
T1703 4950-4955 VB denotes being
T1704 4956-4958 DT denotes an
T1705 4959-4971 NN denotes intermediate
T1706 4972-4974 IN denotes of
T1707 4975-4980 JJ denotes viral
T1708 4981-4992 NN denotes replication
T1709 4994-4998 NN denotes TLR3
T1710 4999-5002 CC denotes and
T1711 5003-5008 NN denotes RIG-I
T1712 5009-5013 VB denotes have
T1713 5014-5018 VB denotes been
T1714 5019-5029 VB denotes implicated
T1715 5030-5032 IN denotes as
T1716 5033-5040 NN denotes sensors
T1717 5041-5043 IN denotes of
T1718 5044-5047 NN denotes IAV
T1719 5048-5057 NN denotes infection
T1720 5058-5059 -LRB- denotes [
T1721 5059-5061 CD denotes 10
T1722 5061-5062 -RRB- denotes ]
T1723 5062-5063 CD denotes –
T1724 5063-5064 -LRB- denotes [
T1725 5064-5066 CD denotes 12
T1726 5066-5067 -RRB- denotes ]
T1727 5069-5073 DT denotes Both
T1728 5074-5083 NN denotes receptors
T1729 5084-5094 VB denotes contribute
T1730 5095-5097 TO denotes to
T1731 5098-5101 DT denotes the
T1732 5102-5117 JJ denotes proinflammatory
T1733 5118-5126 NN denotes response
T1734 5127-5129 TO denotes to
T1735 5130-5133 NN denotes IAV
T1736 5133-5134 -COMMA- denotes ,
T1737 5135-5138 CC denotes but
T1738 5139-5142 DT denotes the
T1739 5143-5153 NN denotes initiation
T1740 5154-5156 IN denotes of
T1741 5157-5160 DT denotes the
T1742 5161-5167 JJ denotes innate
T1743 5168-5177 JJ denotes antiviral
T1744 5178-5184 JJ denotes immune
T1745 5185-5193 NN denotes response
T1746 5194-5201 RB denotes largely
T1747 5202-5209 VB denotes depends
T1748 5210-5212 IN denotes on
T1749 5213-5218 NN denotes RIG-I
T1750 5219-5227 VB denotes mediated
T1751 5228-5237 NN denotes signaling
T1752 5238-5239 -LRB- denotes [
T1753 5239-5241 CD denotes 13
T1754 5241-5242 -RRB- denotes ]
T1755 5244-5257 RB denotes Interestingly
T1756 5257-5258 -COMMA- denotes ,
T1757 5259-5264 NN denotes RIG-I
T1758 5265-5274 JJ denotes deficient
T1759 5275-5279 NN denotes mice
T1760 5280-5283 VB denotes are
T1761 5284-5290 RB denotes highly
T1762 5291-5302 JJ denotes susceptible
T1763 5303-5305 TO denotes to
T1764 5306-5309 NN denotes IAV
T1765 5310-5311 -LRB- denotes [
T1766 5311-5313 CD denotes 14
T1767 5313-5314 -RRB- denotes ]
T1768 5314-5315 -COMMA- denotes ,
T1769 5316-5317 -LRB- denotes [
T1770 5317-5319 CD denotes 15
T1771 5319-5320 -RRB- denotes ]
T1772 5320-5321 -COMMA- denotes ,
T1773 5322-5329 IN denotes whereas
T1774 5330-5334 NN denotes TLR3
T1775 5335-5344 JJ denotes deficient
T1776 5345-5349 NN denotes mice
T1777 5350-5354 VB denotes have
T1778 5355-5356 DT denotes a
T1779 5357-5365 NN denotes survival
T1780 5366-5375 NN denotes advantage
T1781 5376-5378 TO denotes to
T1782 5379-5384 JJ denotes acute
T1783 5385-5394 NN denotes infection
T1784 5395-5396 -LRB- denotes [
T1785 5396-5398 CD denotes 16
T1786 5398-5399 -RRB- denotes ]
T1787 5401-5406 DT denotes These
T1788 5407-5414 NN denotes results
T1789 5415-5423 VB denotes indicate
T1790 5424-5428 IN denotes that
T1791 5429-5431 DT denotes an
T1792 5432-5441 NN denotes imbalance
T1793 5442-5449 IN denotes between
T1794 5450-5453 DT denotes the
T1795 5454-5464 JJ denotes beneficial
T1796 5465-5468 CC denotes and
T1797 5469-5476 JJ denotes harmful
T1798 5477-5484 NN denotes effects
T1799 5485-5487 IN denotes of
T1800 5488-5497 NN denotes mediators
T1801 5498-5506 VB denotes released
T1802 5507-5509 IN denotes by
T1803 5510-5516 JJ denotes immune
T1804 5517-5522 NN denotes cells
T1805 5523-5525 VB denotes is
T1806 5526-5532 JJ denotes likely
T1807 5533-5535 TO denotes to
T1808 5536-5546 VB denotes contribute
T1809 5547-5549 TO denotes to
T1810 5550-5553 DT denotes the
T1811 5554-5566 NN denotes pathogenesis
T1812 5567-5569 IN denotes of
T1813 5570-5579 NN denotes influenza
T1814 5581-5586 NN denotes RIG-I
T1815 5587-5595 VB denotes contains
T1816 5596-5597 DT denotes a
T1817 5598-5608 JJ denotes C-terminal
T1818 5609-5615 NN denotes DExD/H
T1819 5616-5619 NN denotes box
T1820 5620-5628 NN denotes helicase
T1821 5629-5635 NN denotes domain
T1822 5635-5636 -COMMA- denotes ,
T1823 5637-5642 WDT denotes which
T1824 5643-5645 VB denotes is
T1825 5646-5654 VB denotes required
T1826 5655-5658 IN denotes for
T1827 5659-5665 NN denotes ligand
T1828 5666-5677 NN denotes recognition
T1829 5677-5678 -COMMA- denotes ,
T1830 5679-5682 CC denotes and
T1831 5683-5686 CD denotes two
T1832 5687-5697 JJ denotes N-terminal
T1833 5698-5702 NN denotes CARD
T1834 5703-5710 NN denotes domains
T1835 5712-5716 IN denotes Upon
T1836 5717-5723 NN denotes ligand
T1837 5724-5731 NN denotes binding
T1838 5731-5732 -COMMA- denotes ,
T1839 5733-5736 DT denotes the
T1840 5737-5741 NN denotes CARD
T1841 5742-5749 NN denotes domains
T1842 5750-5752 IN denotes of
T1843 5753-5758 NN denotes RIG-I
T1844 5759-5768 VB denotes associate
T1845 5769-5773 IN denotes with
T1846 5774-5777 DT denotes the
T1847 5778-5782 NN denotes CARD
T1848 5783-5789 NN denotes domain
T1849 5790-5792 IN denotes of
T1850 5793-5796 DT denotes the
T1851 5797-5801 NN denotes MAVS
T1852 5802-5803 -LRB- denotes (
T1853 5803-5807 RB denotes also
T1854 5808-5814 VB denotes termed
T1855 5815-5820 NN denotes IPS-1
T1856 5820-5821 -COMMA- denotes ,
T1857 5822-5826 NN denotes VISA
T1858 5826-5827 -COMMA- denotes ,
T1859 5828-5834 NNP denotes Cardif
T1860 5834-5835 -RRB- denotes )
T1861 5836-5843 NN denotes adaptor
T1862 5844-5851 NN denotes protein
T1863 5851-5852 -COMMA- denotes ,
T1864 5853-5858 WDT denotes which
T1865 5859-5871 RB denotes subsequently
T1866 5872-5884 VB denotes translocates
T1867 5885-5887 TO denotes to
T1868 5888-5891 CC denotes and
T1869 5892-5899 NN denotes inserts
T1870 5900-5902 IN denotes in
T1871 5903-5906 DT denotes the
T1872 5907-5912 JJ denotes outer
T1873 5913-5926 JJ denotes mitochondrial
T1874 5927-5935 NN denotes membrane
T1875 5936-5939 IN denotes via
T1876 5940-5943 PRP-DOLLAR- denotes its
T1877 5944-5954 JJ denotes C-terminal
T1878 5955-5968 NN denotes transmembrane
T1879 5969-5975 NN denotes domain
T1880 5976-5977 -LRB- denotes [
T1881 5977-5979 CD denotes 17
T1882 5979-5980 -RRB- denotes ]
T1883 5980-5981 CD denotes –
T1884 5981-5982 -LRB- denotes [
T1885 5982-5984 CD denotes 20
T1886 5984-5985 -RRB- denotes ]
T1887 5987-5996 VB denotes Signaling
T1888 5997-6007 RB denotes downstream
T1889 6008-6010 IN denotes of
T1890 6011-6015 NN denotes MAVS
T1891 6016-6024 VB denotes requires
T1892 6025-6028 DT denotes the
T1893 6029-6035 NN denotes action
T1894 6036-6038 IN denotes of
T1895 6039-6046 JJ denotes various
T1896 6047-6056 NN denotes ubiquitin
T1897 6057-6066 VB denotes modifying
T1898 6067-6074 NN denotes enzymes
T1899 6074-6075 -COMMA- denotes ,
T1900 6076-6081 WDT denotes which
T1901 6082-6086 CC denotes both
T1902 6087-6097 RB denotes positively
T1903 6098-6101 CC denotes and
T1904 6102-6112 RB denotes negatively
T1905 6113-6121 VB denotes regulate
T1906 6122-6127 NN denotes RIG-I
T1907 6128-6136 JJ denotes mediated
T1908 6137-6143 NN denotes signal
T1909 6144-6156 NN denotes transduction
T1910 6157-6158 -LRB- denotes [
T1911 6158-6160 CD denotes 21
T1912 6160-6161 -RRB- denotes ]
T1913 6163-6175 JJ denotes K63-specific
T1914 6176-6185 NN denotes ubiquitin
T1915 6186-6193 NN denotes ligases
T1916 6194-6195 -LRB- denotes (
T1917 6195-6198 NN denotes E3s
T1918 6198-6199 -RRB- denotes )
T1919 6199-6200 -COMMA- denotes ,
T1920 6201-6205 JJ denotes such
T1921 6206-6208 IN denotes as
T1922 6209-6215 NN denotes TRIM25
T1923 6216-6217 -LRB- denotes [
T1924 6217-6219 CD denotes 22
T1925 6219-6220 -RRB- denotes ]
T1926 6221-6224 CC denotes and
T1927 6225-6231 NNP denotes Riplet
T1928 6232-6233 -LRB- denotes [
T1929 6233-6235 CD denotes 23
T1930 6235-6236 -RRB- denotes ]
T1931 6236-6237 -COMMA- denotes ,
T1932 6238-6239 -LRB- denotes [
T1933 6239-6241 CD denotes 24
T1934 6241-6242 -RRB- denotes ]
T1935 6242-6243 -COMMA- denotes ,
T1936 6244-6248 VB denotes have
T1937 6249-6253 VB denotes been
T1938 6254-6259 VB denotes shown
T1939 6260-6262 TO denotes to
T1940 6263-6271 RB denotes directly
T1941 6272-6279 VB denotes promote
T1942 6280-6285 NN denotes RIG-I
T1943 6286-6296 NN denotes activation
T1944 6298-6300 IN denotes In
T1945 6301-6309 NN denotes addition
T1946 6309-6310 -COMMA- denotes ,
T1947 6311-6315 RB denotes well
T1948 6316-6329 VB denotes characterized
T1949 6330-6339 NN denotes ubiquitin
T1950 6340-6347 NN denotes ligases
T1951 6348-6352 JJ denotes such
T1952 6353-6355 IN denotes as
T1953 6356-6361 NN denotes TRAF6
T1954 6362-6363 -LRB- denotes [
T1955 6363-6365 CD denotes 25
T1956 6365-6366 -RRB- denotes ]
T1957 6366-6367 -COMMA- denotes ,
T1958 6368-6369 -LRB- denotes [
T1959 6369-6371 CD denotes 26
T1960 6371-6372 -RRB- denotes ]
T1961 6373-6376 CC denotes and
T1962 6377-6382 NN denotes TRAF3
T1963 6383-6384 -LRB- denotes [
T1964 6384-6386 CD denotes 27
T1965 6386-6387 -RRB- denotes ]
T1966 6388-6395 VB denotes mediate
T1967 6396-6408 RB denotes respectively
T1968 6409-6414 NN denotes NF-κB
T1969 6415-6418 CC denotes and
T1970 6419-6423 NN denotes IRF3
T1971 6424-6434 NN denotes activation
T1972 6435-6439 IN denotes upon
T1973 6440-6445 NN denotes RIG-I
T1974 6446-6457 NN denotes stimulation
T1975 6459-6461 IN denotes On
T1976 6462-6465 DT denotes the
T1977 6466-6471 JJ denotes other
T1978 6472-6476 NN denotes hand
T1979 6476-6477 -COMMA- denotes ,
T1980 6478-6494 VB denotes deubiquitinating
T1981 6495-6502 NN denotes enzymes
T1982 6503-6504 -LRB- denotes (
T1983 6504-6508 NN denotes DUBs
T1984 6508-6509 -RRB- denotes )
T1985 6509-6510 -COMMA- denotes ,
T1986 6511-6515 JJ denotes such
T1987 6516-6518 IN denotes as
T1988 6519-6523 NNP denotes DUBA
T1989 6524-6525 -LRB- denotes [
T1990 6525-6527 CD denotes 28
T1991 6527-6528 -RRB- denotes ]
T1992 6528-6529 -COMMA- denotes ,
T1993 6530-6534 NN denotes CYLD
T1994 6535-6536 -LRB- denotes [
T1995 6536-6538 CD denotes 29
T1996 6538-6539 -RRB- denotes ]
T1997 6539-6540 -COMMA- denotes ,
T1998 6541-6542 -LRB- denotes [
T1999 6542-6544 CD denotes 30
T2000 6544-6545 -RRB- denotes ]
T2001 6546-6549 CC denotes and
T2002 6550-6557 NN denotes OTUB1/2
T2003 6558-6559 -LRB- denotes [
T2004 6559-6561 CD denotes 31
T2005 6561-6562 -RRB- denotes ]
T2006 6563-6567 VB denotes have
T2007 6568-6572 VB denotes been
T2008 6573-6578 VB denotes shown
T2009 6579-6581 TO denotes to
T2010 6582-6592 RB denotes negatively
T2011 6593-6601 VB denotes regulate
T2012 6602-6605 NN denotes RLR
T2013 6606-6615 NN denotes signaling
T2014 6616-6618 IN denotes by
T2015 6619-6631 RB denotes specifically
T2016 6632-6640 VB denotes removing
T2017 6641-6651 JJ denotes K63-linked
T2018 6652-6665 NN denotes polyubiquitin
T2019 6666-6672 NN denotes chains
T2020 6673-6677 IN denotes from
T2021 6678-6685 JJ denotes several
T2022 6686-6695 VB denotes signaling
T2023 6696-6705 NN denotes molecules
T2024 6707-6718 RB denotes Furthermore
T2025 6718-6719 -COMMA- denotes ,
T2026 6720-6727 JJ denotes various
T2027 6728-6740 JJ denotes K48-specific
T2028 6741-6750 NN denotes ubiquitin
T2029 6751-6758 NN denotes ligases
T2030 6758-6759 -COMMA- denotes ,
T2031 6760-6764 JJ denotes such
T2032 6765-6767 IN denotes as
T2033 6768-6772 NN denotes AIP4
T2034 6773-6774 -LRB- denotes [
T2035 6774-6776 CD denotes 32
T2036 6776-6777 -RRB- denotes ]
T2037 6778-6781 CC denotes and
T2038 6782-6789 NN denotes TRIAD3A
T2039 6790-6791 -LRB- denotes [
T2040 6791-6793 CD denotes 33
T2041 6793-6794 -RRB- denotes ]
T2042 6795-6799 NN denotes mark
T2043 6800-6812 RB denotes respectively
T2044 6813-6817 NN denotes MAVS
T2045 6818-6821 CC denotes and
T2046 6822-6827 NN denotes TRAF3
T2047 6828-6831 IN denotes for
T2048 6832-6842 NN denotes proteasome
T2049 6843-6851 VB denotes mediated
T2050 6852-6863 NN denotes degradation
T2051 6863-6864 -COMMA- denotes ,
T2052 6865-6869 RB denotes thus
T2053 6870-6880 VB denotes inhibiting
T2054 6881-6888 JJ denotes further
T2055 6889-6899 JJ denotes downstream
T2056 6900-6909 NN denotes signaling
T2057 6911-6923 RB denotes Additionally
T2058 6923-6924 -COMMA- denotes ,
T2059 6925-6928 DT denotes the
T2060 6929-6939 NN denotes attachment
T2061 6940-6942 IN denotes of
T2062 6943-6955 JJ denotes K48-specific
T2063 6956-6969 NN denotes polyubiquitin
T2064 6970-6976 NN denotes chains
T2065 6977-6979 TO denotes to
T2066 6980-6983 DT denotes the
T2067 6984-6988 NN denotes IRF3
T2068 6989-6992 CC denotes and
T2069 6993-6997 NN denotes IRF7
T2070 6998-7011 NN denotes transcription
T2071 7012-7019 NN denotes factors
T2072 7020-7022 IN denotes by
T2073 7023-7026 NN denotes E3s
T2074 7027-7031 JJ denotes such
T2075 7032-7034 IN denotes as
T2076 7035-7039 NN denotes RAUL
T2077 7040-7041 -LRB- denotes [
T2078 7041-7043 CD denotes 34
T2079 7043-7044 -RRB- denotes ]
T2080 7044-7045 -COMMA- denotes ,
T2081 7046-7052 NN denotes TRIM21
T2082 7053-7054 -LRB- denotes [
T2083 7054-7056 CD denotes 35
T2084 7056-7057 -RRB- denotes ]
T2085 7058-7061 CC denotes and
T2086 7062-7067 NN denotes RBCK1
T2087 7068-7069 -LRB- denotes [
T2088 7069-7071 CD denotes 36
T2089 7071-7072 -RRB- denotes ]
T2090 7073-7080 RB denotes further
T2091 7081-7088 VB denotes dampens
T2092 7089-7098 JJ denotes antiviral
T2093 7099-7105 NN denotes signal
T2094 7106-7118 NN denotes transduction
T2095 7120-7123 NN denotes A20
T2096 7124-7126 VB denotes is
T2097 7127-7129 DT denotes an
T2098 7130-7147 JJ denotes ubiquitin-editing
T2099 7148-7154 NN denotes enzyme
T2100 7155-7164 VB denotes belonging
T2101 7165-7167 TO denotes to
T2102 7168-7171 DT denotes the
T2103 7172-7182 NN denotes OTU-domain
T2104 7183-7189 NN denotes family
T2105 7190-7192 IN denotes of
T2106 7193-7197 NN denotes DUBs
T2107 7199-7212 RB denotes Interestingly
T2108 7212-7213 -COMMA- denotes ,
T2109 7214-7217 NN denotes A20
T2110 7218-7222 RB denotes also
T2111 7223-7230 VB denotes harbors
T2112 7231-7239 JJ denotes atypical
T2113 7240-7244 NN denotes zinc
T2114 7245-7251 NN denotes finger
T2115 7252-7261 JJ denotes dependent
T2116 7262-7274 JJ denotes K48-specific
T2117 7275-7277 NN denotes E3
T2118 7278-7287 NN denotes ubiquitin
T2119 7288-7294 NN denotes ligase
T2120 7295-7303 NN denotes activity
T2121 7305-7309 CC denotes Both
T2122 7310-7319 JJ denotes catalytic
T2123 7320-7323 CC denotes and
T2124 7324-7336 JJ denotes noncatalytic
T2125 7337-7347 NN denotes mechanisms
T2126 7348-7352 VB denotes were
T2127 7353-7363 RB denotes previously
T2128 7364-7369 VB denotes shown
T2129 7370-7372 TO denotes to
T2130 7373-7375 VB denotes be
T2131 7376-7384 VB denotes involved
T2132 7385-7387 IN denotes in
T2133 7388-7391 DT denotes the
T2134 7392-7400 JJ denotes negative
T2135 7401-7411 NN denotes regulation
T2136 7412-7414 IN denotes of
T2137 7415-7430 JJ denotes proinflammatory
T2138 7431-7440 NN denotes signaling
T2139 7441-7443 IN denotes by
T2140 7444-7447 NN denotes A20
T2141 7448-7450 IN denotes in
T2142 7451-7459 NN denotes response
T2143 7460-7462 TO denotes to
T2144 7463-7471 JJ denotes multiple
T2145 7472-7481 NN denotes receptors
T2146 7482-7486 JJ denotes such
T2147 7487-7489 IN denotes as
T2148 7490-7493 NN denotes TNF
T2149 7494-7502 NN denotes receptor
T2150 7503-7504 CD denotes I
T2151 7505-7506 -LRB- denotes [
T2152 7506-7508 CD denotes 37
T2153 7508-7509 -RRB- denotes ]
T2154 7509-7510 CD denotes –
T2155 7510-7511 -LRB- denotes [
T2156 7511-7513 CD denotes 39
T2157 7513-7514 -RRB- denotes ]
T2158 7514-7515 -COMMA- denotes ,
T2159 7516-7520 NN denotes TLR4
T2160 7521-7522 -LRB- denotes [
T2161 7522-7524 CD denotes 40
T2162 7524-7525 -RRB- denotes ]
T2163 7525-7526 -COMMA- denotes ,
T2164 7527-7530 CC denotes and
T2165 7531-7536 NN denotes IL-1R
T2166 7537-7538 -LRB- denotes [
T2167 7538-7540 CD denotes 41
T2168 7540-7541 -RRB- denotes ]
T2169 7543-7546 DT denotes The
T2170 7547-7564 JJ denotes anti-inflammatory
T2171 7565-7569 NN denotes role
T2172 7570-7572 IN denotes of
T2173 7573-7576 NN denotes A20
T2174 7577-7579 VB denotes is
T2175 7580-7587 RB denotes clearly
T2176 7588-7600 VB denotes demonstrated
T2177 7601-7603 IN denotes by
T2178 7604-7607 DT denotes the
T2179 7608-7612 NN denotes fact
T2180 7613-7617 IN denotes that
T2181 7618-7621 NN denotes A20
T2182 7622-7631 JJ denotes deficient
T2183 7632-7636 NN denotes mice
T2184 7637-7640 VB denotes die
T2185 7641-7646 RB denotes early
T2186 7647-7652 IN denotes after
T2187 7653-7658 NN denotes birth
T2188 7659-7662 JJ denotes due
T2189 7663-7665 TO denotes to
T2190 7666-7672 JJ denotes severe
T2191 7673-7684 JJ denotes multi-organ
T2192 7685-7697 NN denotes inflammation
T2193 7698-7701 CC denotes and
T2194 7702-7710 NN denotes cachexia
T2195 7711-7712 -LRB- denotes [
T2196 7712-7714 CD denotes 37
T2197 7714-7715 -RRB- denotes ]
T2198 7717-7721 RB denotes More
T2199 7722-7730 RB denotes recently
T2200 7730-7731 -COMMA- denotes ,
T2201 7732-7736 NN denotes gene
T2202 7737-7746 NN denotes targeting
T2203 7747-7749 IN denotes of
T2204 7750-7753 NN denotes A20
T2205 7754-7756 IN denotes in
T2206 7757-7765 JJ denotes specific
T2207 7766-7770 NN denotes cell
T2208 7771-7776 NN denotes types
T2209 7777-7780 VB denotes was
T2210 7781-7786 VB denotes shown
T2211 7787-7789 TO denotes to
T2212 7790-7792 VB denotes be
T2213 7793-7803 VB denotes associated
T2214 7804-7808 IN denotes with
T2215 7809-7821 NN denotes autoimmunity
T2216 7822-7825 CC denotes and
T2217 7826-7833 JJ denotes chronic
T2218 7834-7846 NN denotes inflammation
T2219 7847-7848 -LRB- denotes [
T2220 7848-7850 CD denotes 42
T2221 7850-7851 -RRB- denotes ]
T2222 7851-7852 CD denotes –
T2223 7852-7853 -LRB- denotes [
T2224 7853-7855 CD denotes 48
T2225 7855-7856 -RRB- denotes ]
T2226 7856-7857 -COMMA- denotes ,
T2227 7858-7865 RB denotes further
T2228 7866-7878 VB denotes illustrating
T2229 7879-7883 IN denotes that
T2230 7884-7887 NN denotes A20
T2231 7888-7890 VB denotes is
T2232 7891-7893 DT denotes an
T2233 7894-7903 JJ denotes important
T2234 7904-7909 NN denotes brake
T2235 7910-7912 IN denotes on
T2236 7913-7916 DT denotes the
T2237 7917-7929 JJ denotes inflammatory
T2238 7930-7938 NN denotes response
T2239 7940-7943 DT denotes The
T2240 7944-7953 NN denotes relevance
T2241 7954-7956 IN denotes of
T2242 7957-7962 DT denotes these
T2243 7963-7971 NN denotes findings
T2244 7972-7975 IN denotes for
T2245 7976-7981 JJ denotes human
T2246 7982-7989 NN denotes disease
T2247 7990-7993 VB denotes has
T2248 7994-8002 RB denotes recently
T2249 8003-8007 VB denotes been
T2250 8008-8019 VB denotes illustrated
T2251 8020-8027 IN denotes through
T2252 8028-8031 DT denotes the
T2253 8032-8046 NN denotes identification
T2254 8047-8049 IN denotes of
T2255 8050-8063 NN denotes polymorphisms
T2256 8064-8066 IN denotes in
T2257 8067-8070 DT denotes the
T2258 8071-8074 NN denotes A20
T2259 8075-8080 NN denotes locus
T2260 8081-8085 WDT denotes that
T2261 8086-8089 VB denotes are
T2262 8090-8100 VB denotes associated
T2263 8101-8105 IN denotes with
T2264 8106-8113 JJ denotes several
T2265 8114-8124 JJ denotes autoimmune
T2266 8125-8133 NN denotes diseases
T2267 8134-8137 CC denotes and
T2268 8138-8145 JJ denotes chronic
T2269 8146-8158 NN denotes inflammation
T2270 8159-8160 -LRB- denotes [
T2271 8160-8162 CD denotes 45
T2272 8162-8163 -RRB- denotes ]
T2273 8165-8167 IN denotes In
T2274 8168-8176 NN denotes contrast
T2275 8177-8179 TO denotes to
T2276 8180-8183 PRP-DOLLAR- denotes its
T2277 8184-8188 RB denotes well
T2278 8189-8200 VB denotes established
T2279 8201-8209 NN denotes function
T2280 8210-8212 IN denotes in
T2281 8213-8216 DT denotes the
T2282 8217-8227 NN denotes regulation
T2283 8228-8230 IN denotes of
T2284 8231-8246 JJ denotes proinflammatory
T2285 8247-8256 NN denotes responses
T2286 8256-8257 -COMMA- denotes ,
T2287 8258-8261 DT denotes the
T2288 8262-8266 NN denotes role
T2289 8267-8269 IN denotes of
T2290 8270-8273 NN denotes A20
T2291 8274-8276 IN denotes in
T2292 8277-8280 DT denotes the
T2293 8281-8291 NN denotes regulation
T2294 8292-8294 IN denotes of
T2295 8295-8304 JJ denotes antiviral
T2296 8305-8311 JJ denotes immune
T2297 8312-8321 NN denotes responses
T2298 8322-8324 VB denotes is
T2299 8325-8329 RB denotes less
T2300 8330-8334 RB denotes well
T2301 8335-8344 VB denotes described
T2302 8345-8348 CC denotes and
T2303 8349-8356 VB denotes limited
T2304 8357-8359 TO denotes to
T2305 8360-8361 DT denotes a
T2306 8362-8368 NN denotes number
T2307 8369-8371 IN denotes of
T2308 8372-8374 FW denotes in
T2309 8375-8380 FW denotes vitro
T2310 8381-8388 NN denotes studies
T2311 8389-8394 VB denotes using
T2312 8395-8409 NN denotes overexpression
T2313 8410-8412 CC denotes or
T2314 8413-8422 NN denotes silencing
T2315 8423-8425 IN denotes in
T2316 8426-8434 JJ denotes specific
T2317 8435-8439 NN denotes cell
T2318 8440-8445 NN denotes lines
T2319 8445-8446 -COMMA- denotes ,
T2320 8447-8457 VB denotes indicating
T2321 8458-8462 IN denotes that
T2322 8463-8466 NN denotes A20
T2323 8467-8470 MD denotes may
T2324 8471-8479 VB denotes regulate
T2325 8480-8486 NN denotes RIG-I-
T2326 8487-8490 CC denotes and
T2327 8491-8503 JJ denotes TLR3-induced
T2328 8504-8513 NN denotes signaling
T2329 8514-8516 TO denotes to
T2330 8517-8522 NN denotes NF-κB
T2331 8523-8526 CC denotes and
T2332 8527-8532 NN denotes IRF-3
T2333 8533-8534 -LRB- denotes [
T2334 8534-8536 CD denotes 49
T2335 8536-8537 -RRB- denotes ]
T2336 8537-8538 CD denotes –
T2337 8538-8539 -LRB- denotes [
T2338 8539-8541 CD denotes 52
T2339 8541-8542 -RRB- denotes ]
T2340 8544-8551 RB denotes However
T2341 8551-8552 -COMMA- denotes ,
T2342 8553-8556 DT denotes the
T2343 8557-8564 JJ denotes precise
T2344 8565-8567 FW denotes in
T2345 8568-8572 FW denotes vivo
T2346 8573-8577 NN denotes role
T2347 8578-8580 IN denotes of
T2348 8581-8584 NN denotes A20
T2349 8585-8587 IN denotes in
T2350 8588-8591 DT denotes the
T2351 8592-8600 NN denotes response
T2352 8601-8603 TO denotes to
T2353 8604-8609 JJ denotes viral
T2354 8610-8619 NN denotes infection
T2355 8620-8627 VB denotes remains
T2356 8628-8630 TO denotes to
T2357 8631-8633 VB denotes be
T2358 8634-8643 VB denotes clarified
T2359 8645-8650 VB denotes Using
T2360 8651-8658 JJ denotes myeloid
T2361 8659-8663 NN denotes cell
T2362 8664-8672 JJ denotes specific
T2363 8673-8676 NN denotes A20
T2364 8677-8685 NN denotes knockout
T2365 8686-8690 NN denotes mice
T2366 8691-8692 -LRB- denotes (
T2367 8692-8702 NN denotes A20myel-KO
T2368 8702-8703 -RRB- denotes )
T2369 8704-8708 WDT denotes that
T2370 8709-8713 VB denotes were
T2371 8714-8722 RB denotes recently
T2372 8723-8732 VB denotes generated
T2373 8733-8735 IN denotes in
T2374 8736-8739 PRP-DOLLAR- denotes our
T2375 8740-8743 NN denotes lab
T2376 8744-8747 CC denotes and
T2377 8748-8755 JJ denotes primary
T2378 8756-8761 NN denotes cells
T2379 8762-8769 VB denotes derived
T2380 8770-8772 IN denotes of
T2381 8773-8778 DT denotes these
T2382 8779-8783 NN denotes mice
T2383 8783-8784 -COMMA- denotes ,
T2384 8785-8787 PRP denotes we
T2385 8788-8792 RB denotes here
T2386 8793-8800 VB denotes provide
T2387 8801-8809 NN denotes evidence
T2388 8810-8814 IN denotes that
T2389 8815-8818 NN denotes A20
T2390 8819-8821 VB denotes is
T2391 8822-8823 DT denotes a
T2392 8824-8831 JJ denotes crucial
T2393 8832-8840 JJ denotes negative
T2394 8841-8850 NN denotes regulator
T2395 8851-8853 IN denotes of
T2396 8854-8865 JJ denotes IAV-induced
T2397 8866-8881 JJ denotes proinflammatory
T2398 8882-8885 CC denotes and
T2399 8886-8895 JJ denotes antiviral
T2400 8896-8905 NN denotes signaling
T2401 8906-8908 IN denotes in
T2402 8909-8920 NN denotes macrophages
T2403 8922-8935 RB denotes Interestingly
T2404 8935-8936 -COMMA- denotes ,
T2405 8937-8947 NN denotes A20myel-KO
T2406 8948-8952 NN denotes mice
T2407 8953-8957 VB denotes show
T2408 8958-8966 VB denotes enhanced
T2409 8967-8975 NN denotes survival
T2410 8976-8979 CC denotes and
T2411 8980-8987 VB denotes reduced
T2412 8988-8997 NN denotes morbidity
T2413 8998-9000 IN denotes in
T2414 9001-9009 NN denotes response
T2415 9010-9012 TO denotes to
T2416 9013-9016 NN denotes IAV
T2417 9017-9021 NN denotes lung
T2418 9022-9031 NN denotes infection
T2419 9032-9040 VB denotes compared
T2420 9041-9043 TO denotes to
T2421 9044-9048 JJ denotes wild
T2422 9049-9053 NN denotes type
T2423 9054-9058 NN denotes mice
T2424 9060-9070 NN denotes Protection
T2425 9071-9078 IN denotes against
T2426 9079-9082 NN denotes IAV
T2427 9083-9085 IN denotes in
T2428 9086-9096 NN denotes A20myel-KO
T2429 9097-9101 NN denotes mice
T2430 9102-9104 VB denotes is
T2431 9105-9115 VB denotes associated
T2432 9116-9120 IN denotes with
T2433 9121-9130 VB denotes increased
T2434 9131-9139 NN denotes cytokine
T2435 9140-9143 CC denotes and
T2436 9144-9153 NN denotes chemokine
T2437 9154-9164 NN denotes production
T2438 9164-9165 -COMMA- denotes ,
T2439 9166-9175 VB denotes augmented
T2440 9176-9187 NN denotes recruitment
T2441 9188-9190 IN denotes of
T2442 9191-9197 JJ denotes innate
T2443 9198-9204 JJ denotes immune
T2444 9205-9210 NN denotes cells
T2445 9211-9215 JJ denotes such
T2446 9216-9218 IN denotes as
T2447 9219-9229 NN denotes neutophils
T2448 9230-9233 CC denotes and
T2449 9234-9242 JJ denotes alveolar
T2450 9243-9254 NN denotes macrophages
T2451 9254-9255 -COMMA- denotes ,
T2452 9256-9259 CC denotes and
T2453 9260-9268 VB denotes enhanced
T2454 9269-9274 JJ denotes viral
T2455 9275-9284 NN denotes clearance
T2456 9286-9291 DT denotes These
T2457 9292-9299 NN denotes results
T2458 9300-9307 VB denotes suggest
T2459 9308-9312 IN denotes that
T2460 9313-9321 VB denotes boosting
T2461 9322-9325 DT denotes the
T2462 9326-9332 JJ denotes innate
T2463 9333-9339 JJ denotes immune
T2464 9340-9348 NN denotes response
T2465 9349-9351 TO denotes to
T2466 9352-9355 NN denotes IAV
T2467 9356-9358 IN denotes by
T2468 9359-9368 VB denotes targeting
T2469 9369-9372 NN denotes A20
T2470 9373-9381 NN denotes activity
T2471 9382-9384 IN denotes in
T2472 9385-9392 JJ denotes myeloid
T2473 9393-9398 NN denotes cells
T2474 9399-9404 MD denotes might
T2475 9405-9409 VB denotes have
T2476 9410-9421 JJ denotes therapeutic
T2477 9422-9431 NN denotes potential
T5083 9443-9446 NN denotes A20
T5084 9447-9455 VB denotes inhibits
T5085 9456-9469 JJ denotes RIG-I-induced
T5086 9470-9475 NN denotes NF-κB
T5087 9476-9479 CC denotes and
T5088 9480-9484 NN denotes IRF3
T5089 9485-9495 NN denotes activation
T5090 9496-9501 NN denotes RIG-I
T5091 9502-9511 NN denotes signaling
T5092 9512-9519 VB denotes induces
T5093 9520-9523 DT denotes the
T5094 9524-9534 NN denotes activation
T5095 9535-9537 IN denotes of
T5096 9538-9543 NN denotes NF-κB
T5097 9543-9544 -COMMA- denotes ,
T5098 9545-9549 NN denotes IRF3
T5099 9550-9553 CC denotes and
T5100 9554-9558 NN denotes IRF7
T5101 9559-9572 NN denotes transcription
T5102 9573-9580 NN denotes factors
T5103 9580-9581 -COMMA- denotes ,
T5104 9582-9587 WDT denotes which
T5105 9588-9595 VB denotes promote
T5106 9596-9599 DT denotes the
T5107 9600-9610 NN denotes expression
T5108 9611-9613 IN denotes of
T5109 9614-9629 JJ denotes proinflammatory
T5110 9630-9639 NN denotes cytokines
T5111 9640-9643 CC denotes and
T5112 9644-9648 NN denotes type
T5113 9649-9650 CD denotes I
T5114 9651-9655 NN denotes IFNs
T5115 9656-9660 WDT denotes that
T5116 9661-9669 VB denotes restrict
T5117 9670-9677 RB denotes further
T5118 9678-9683 JJ denotes viral
T5119 9684-9695 NN denotes propagation
T5120 9697-9705 JJ denotes Previous
T5121 9706-9713 NN denotes studies
T5122 9714-9718 VB denotes have
T5123 9719-9724 VB denotes shown
T5124 9725-9729 IN denotes that
T5125 9730-9741 RB denotes ectopically
T5126 9742-9751 VB denotes expressed
T5127 9752-9755 NN denotes A20
T5128 9756-9766 RB denotes negatively
T5129 9767-9776 VB denotes regulates
T5130 9777-9782 NN denotes NF-κB
T5131 9783-9786 CC denotes and
T5132 9787-9791 NN denotes IRF3
T5133 9792-9802 NN denotes activation
T5134 9803-9807 IN denotes upon
T5135 9808-9813 NN denotes RIG-I
T5136 9814-9825 NN denotes stimulation
T5137 9826-9827 -LRB- denotes [
T5138 9827-9829 CD denotes 50
T5139 9829-9830 -RRB- denotes ]
T5140 9830-9831 CD denotes –
T5141 9831-9832 -LRB- denotes [
T5142 9832-9834 CD denotes 52
T5143 9834-9835 -RRB- denotes ]
T5144 9837-9846 RB denotes Similarly
T5145 9846-9847 -COMMA- denotes ,
T5146 9848-9850 PRP denotes we
T5147 9851-9855 VB denotes show
T5148 9856-9860 IN denotes that
T5149 9861-9864 NN denotes A20
T5150 9865-9879 NN denotes overexpression
T5151 9880-9882 IN denotes in
T5152 9883-9890 NN denotes HEK293T
T5153 9891-9896 NN denotes cells
T5154 9897-9905 VB denotes prevents
T5155 9906-9912 NN denotes NF-κB-
T5156 9913-9916 CC denotes and
T5157 9917-9931 JJ denotes IRF3-dependent
T5158 9932-9942 NN denotes luciferase
T5159 9943-9951 NN denotes reporter
T5160 9952-9956 NN denotes gene
T5161 9957-9967 NN denotes activation
T5162 9968-9975 VB denotes induced
T5163 9976-9978 IN denotes by
T5164 9979-9991 NN denotes transfection
T5165 9992-9994 IN denotes of
T5166 9995-9996 DT denotes a
T5167 9997-10006 VB denotes truncated
T5168 10007-10019 JJ denotes constitutive
T5169 10020-10026 JJ denotes active
T5170 10027-10031 NN denotes form
T5171 10032-10034 IN denotes of
T5172 10035-10040 NN denotes RIG-I
T5173 10041-10042 -LRB- denotes [
T5174 10042-10044 CD denotes 53
T5175 10044-10045 -RRB- denotes ]
T5176 10045-10046 -COMMA- denotes ,
T5177 10047-10060 VB denotes corresponding
T5178 10061-10063 TO denotes to
T5179 10064-10068 RB denotes only
T5180 10069-10072 DT denotes the
T5181 10073-10076 CD denotes two
T5182 10077-10087 JJ denotes N-terminal
T5183 10088-10092 NN denotes CARD
T5184 10093-10100 NN denotes domains
T5185 10101-10103 IN denotes of
T5186 10104-10109 NN denotes RIG-I
T5187 10110-10111 -LRB- denotes [
T5188 10111-10116 NN denotes RIG-I
T5189 10117-10118 -LRB- denotes (
T5190 10118-10123 NN denotes 2CARD
T5191 10123-10124 -RRB- denotes )
T5192 10124-10125 -RRB- denotes ]
T5193 10126-10127 -LRB- denotes (
T5194 10127-10133 NN denotes figure
T5195 10134-10136 NN denotes 1A
T5196 10136-10137 -COMMA- denotes ,
T5197 10138-10142 JJ denotes left
T5198 10143-10146 CC denotes and
T5199 10147-10153 JJ denotes middle
T5200 10154-10159 NN denotes graph
T5201 10159-10160 -RRB- denotes )
T5202 10162-10164 PRP denotes We
T5203 10165-10169 RB denotes next
T5204 10170-10182 VB denotes investigated
T5205 10183-10190 IN denotes whether
T5206 10191-10194 NN denotes A20
T5207 10195-10199 RB denotes also
T5208 10200-10208 VB denotes inhibits
T5209 10209-10213 NN denotes IRF7
T5210 10214-10224 NN denotes activation
T5211 10226-10232 IN denotes Unlike
T5212 10233-10237 NN denotes IRF3
T5213 10237-10238 -COMMA- denotes ,
T5214 10239-10243 NN denotes IRF7
T5215 10244-10246 VB denotes is
T5216 10247-10250 RB denotes not
T5217 10251-10253 CC denotes or
T5218 10254-10260 RB denotes weakly
T5219 10261-10270 VB denotes expressed
T5220 10271-10276 IN denotes under
T5221 10277-10282 NN denotes naïve
T5222 10283-10293 NN denotes conditions
T5223 10294-10297 CC denotes and
T5224 10298-10302 NN denotes IRF7
T5225 10303-10310 NN denotes protein
T5226 10311-10317 NN denotes levels
T5227 10318-10321 VB denotes are
T5228 10322-10329 RB denotes rapidly
T5229 10330-10341 VB denotes upregulated
T5230 10342-10346 IN denotes upon
T5231 10347-10360 JJ denotes virus-induced
T5232 10361-10365 NN denotes IRF3
T5233 10366-10376 NN denotes activation
T5234 10377-10378 -LRB- denotes [
T5235 10378-10380 CD denotes 54
T5236 10380-10381 -RRB- denotes ]
T5237 10381-10382 -COMMA- denotes ,
T5238 10383-10384 -LRB- denotes [
T5239 10384-10386 CD denotes 55
T5240 10386-10387 -RRB- denotes ]
T5241 10389-10391 TO denotes To
T5242 10392-10401 VB denotes determine
T5243 10402-10405 DT denotes the
T5244 10406-10412 NN denotes effect
T5245 10413-10415 IN denotes of
T5246 10416-10419 NN denotes A20
T5247 10420-10422 IN denotes on
T5248 10423-10427 NN denotes IRF7
T5249 10428-10438 NN denotes activation
T5250 10438-10439 -COMMA- denotes ,
T5251 10440-10442 PRP denotes we
T5252 10443-10452 RB denotes therefore
T5253 10453-10464 VB denotes transfected
T5254 10465-10470 JJ denotes minor
T5255 10471-10478 NN denotes amounts
T5256 10479-10481 IN denotes of
T5257 10482-10484 DT denotes an
T5258 10485-10489 NN denotes IRF7
T5259 10490-10500 NN denotes expression
T5260 10501-10508 NN denotes plasmid
T5261 10509-10517 RB denotes together
T5262 10518-10522 IN denotes with
T5263 10523-10531 NN denotes plasmids
T5264 10532-10540 VB denotes encoding
T5265 10541-10546 NN denotes RIG-I
T5266 10547-10548 -LRB- denotes (
T5267 10548-10553 NN denotes 2CARD
T5268 10553-10554 -RRB- denotes )
T5269 10554-10555 -COMMA- denotes ,
T5270 10556-10559 NN denotes A20
T5271 10560-10563 CC denotes and
T5272 10564-10566 DT denotes an
T5273 10567-10580 JJ denotes IRF7-specific
T5274 10581-10586 NN denotes IFNα4
T5275 10587-10597 NN denotes luciferase
T5276 10598-10606 NN denotes reporter
T5277 10607-10616 NN denotes construct
T5278 10618-10623 NN denotes RIG-I
T5279 10624-10625 -LRB- denotes (
T5280 10625-10630 NN denotes 2CARD
T5281 10630-10631 -RRB- denotes )
T5282 10632-10642 NN denotes expression
T5283 10643-10645 IN denotes in
T5284 10646-10649 DT denotes the
T5285 10650-10657 NN denotes absence
T5286 10658-10660 IN denotes of
T5287 10661-10665 NN denotes IRF7
T5288 10666-10679 NN denotes co-expression
T5289 10680-10686 VB denotes showed
T5290 10687-10697 JJ denotes negligible
T5291 10698-10703 NN denotes IFNα4
T5292 10704-10712 NN denotes promoter
T5293 10713-10723 NN denotes activation
T5294 10724-10725 -LRB- denotes (
T5295 10725-10729 JJ denotes grey
T5296 10730-10733 NN denotes bar
T5297 10733-10734 -COMMA- denotes ,
T5298 10735-10741 NN denotes figure
T5299 10742-10744 NN denotes 1A
T5300 10744-10745 -COMMA- denotes ,
T5301 10746-10751 JJ denotes right
T5302 10752-10757 NN denotes graph
T5303 10757-10758 -RRB- denotes )
T5304 10758-10759 -COMMA- denotes ,
T5305 10760-10767 IN denotes whereas
T5306 10768-10779 JJ denotes significant
T5307 10780-10788 NN denotes reporter
T5308 10789-10793 NN denotes gene
T5309 10794-10804 NN denotes expression
T5310 10805-10808 VB denotes was
T5311 10809-10817 VB denotes observed
T5312 10818-10820 IN denotes in
T5313 10821-10824 DT denotes the
T5314 10825-10833 NN denotes presence
T5315 10834-10836 IN denotes of
T5316 10837-10841 NN denotes IRF7
T5317 10843-10850 JJ denotes Similar
T5318 10851-10853 TO denotes to
T5319 10854-10857 PRP-DOLLAR- denotes its
T5320 10858-10868 JJ denotes inhibitory
T5321 10869-10875 NN denotes effect
T5322 10876-10878 IN denotes on
T5323 10879-10884 NN denotes NF-κB
T5324 10885-10888 CC denotes and
T5325 10889-10893 NN denotes IRF3
T5326 10894-10904 NN denotes activation
T5327 10904-10905 -COMMA- denotes ,
T5328 10906-10909 NN denotes A20
T5329 10910-10914 RB denotes also
T5330 10915-10924 VB denotes prevented
T5331 10925-10938 JJ denotes RIG-I-induced
T5332 10939-10943 NN denotes IRF7
T5333 10944-10954 NN denotes activation
T5334 10955-10956 -LRB- denotes (
T5335 10956-10962 NN denotes figure
T5336 10963-10965 NN denotes 1A
T5337 10965-10966 -COMMA- denotes ,
T5338 10967-10972 JJ denotes right
T5339 10973-10978 NN denotes graph
T5340 10978-10979 -RRB- denotes )
T5341 10981-10986 DT denotes These
T5342 10987-10994 NN denotes results
T5343 10995-11006 VB denotes demonstrate
T5344 11007-11010 DT denotes the
T5345 11011-11020 NN denotes potential
T5346 11021-11023 IN denotes of
T5347 11024-11027 NN denotes A20
T5348 11028-11030 TO denotes to
T5349 11031-11038 VB denotes inhibit
T5350 11039-11052 JJ denotes RIG-I-induced
T5351 11053-11058 NN denotes NF-κB
T5352 11059-11062 CC denotes and
T5353 11063-11069 NN denotes IRF3/7
T5354 11070-11080 NN denotes activation
T19463 11126-11129 NN denotes A20
T19464 11130-11138 VB denotes inhibits
T19465 11139-11144 NN denotes NF-κB
T19466 11145-11148 CC denotes and
T19467 11149-11153 NN denotes IRF3
T19468 11154-11164 NN denotes activation
T19469 11165-11167 IN denotes in
T19470 11168-11176 NN denotes response
T19471 11177-11179 TO denotes to
T19472 11180-11185 NN denotes RIG-I
T19473 11186-11197 NN denotes stimulation
T19474 11199-11200 -LRB- denotes (
T19475 11200-11201 NN denotes A
T19476 11201-11202 -RRB- denotes )
T19477 11203-11210 NN denotes HEK293T
T19478 11211-11216 NN denotes cells
T19479 11217-11221 VB denotes were
T19480 11222-11233 VB denotes transfected
T19481 11234-11238 IN denotes with
T19482 11239-11244 NN denotes NF-κB
T19483 11245-11246 -LRB- denotes (
T19484 11246-11250 JJ denotes left
T19485 11250-11251 -RRB- denotes )
T19486 11251-11252 -COMMA- denotes ,
T19487 11253-11257 NN denotes IRF3
T19488 11258-11259 -LRB- denotes (
T19489 11259-11265 JJ denotes middle
T19490 11265-11266 -RRB- denotes )
T19491 11267-11269 CC denotes or
T19492 11270-11274 NN denotes IRF7
T19493 11275-11284 JJ denotes dependent
T19494 11285-11295 NN denotes luciferase
T19495 11296-11304 NN denotes reporter
T19496 11305-11306 -LRB- denotes (
T19497 11306-11311 JJ denotes right
T19498 11311-11312 -RRB- denotes )
T19499 11313-11321 NN denotes plasmids
T19500 11321-11322 -COMMA- denotes ,
T19501 11323-11331 RB denotes together
T19502 11332-11336 IN denotes with
T19503 11337-11345 NN denotes plasmids
T19504 11346-11356 VB denotes expressing
T19505 11357-11362 NN denotes RIG-I
T19506 11363-11364 -LRB- denotes (
T19507 11364-11369 NN denotes 2CARD
T19508 11369-11370 -RRB- denotes )
T19509 11370-11371 -COMMA- denotes ,
T19510 11372-11376 NN denotes IRF7
T19511 11377-11378 -LRB- denotes (
T19512 11378-11383 JJ denotes right
T19513 11383-11384 -RRB- denotes )
T19514 11385-11388 CC denotes and
T19515 11389-11399 VB denotes increasing
T19516 11400-11407 NN denotes amounts
T19517 11408-11410 IN denotes of
T19518 11411-11414 NN denotes A20
T19519 11416-11426 NN denotes Luciferase
T19520 11427-11435 NN denotes activity
T19521 11436-11438 IN denotes in
T19522 11439-11443 NN denotes cell
T19523 11444-11452 NN denotes extracts
T19524 11453-11456 VB denotes was
T19525 11457-11465 VB denotes analyzed
T19526 11466-11468 IN denotes in
T19527 11469-11470 DT denotes a
T19528 11471-11482 NN denotes luminometer
T19529 11484-11491 NN denotes Numbers
T19530 11492-11495 VB denotes are
T19531 11496-11504 NN denotes averages
T19532 11505-11508 CC denotes +/−
T19533 11509-11511 NN denotes SD
T19534 11512-11514 IN denotes of
T19535 11515-11516 CD denotes 3
T19536 11517-11524 NN denotes samples
T19537 11525-11528 IN denotes per
T19538 11529-11536 NN denotes set-up.
T19539 11537-11538 -LRB- denotes (
T19540 11538-11541 NN denotes B–D
T19541 11541-11542 -RRB- denotes )
T19542 11543-11553 NN denotes A20myel-KO
T19543 11554-11557 CC denotes and
T19544 11558-11562 JJ denotes wild
T19545 11563-11567 NN denotes type
T19546 11568-11569 -LRB- denotes (
T19547 11569-11579 NN denotes A20myel-WT
T19548 11579-11580 -RRB- denotes )
T19549 11581-11585 NN denotes BMDM
T19550 11586-11590 VB denotes were
T19551 11591-11602 VB denotes transfected
T19552 11603-11607 IN denotes with
T19553 11608-11611 NN denotes LMW
T19554 11612-11616 NN denotes poly
T19555 11616-11617 -LRB- denotes (
T19556 11617-11618 NN denotes I
T19557 11618-11619 SYM denotes :
T19558 11619-11620 NN denotes C
T19559 11620-11621 -RRB- denotes )
T19560 11622-11625 CC denotes and
T19561 11626-11634 VB denotes analyzed
T19562 11635-11637 IN denotes at
T19563 11638-11647 JJ denotes different
T19564 11648-11652 NN denotes time
T19565 11653-11659 NN denotes points
T19566 11660-11661 -LRB- denotes (
T19567 11661-11668 NN denotes minutes
T19568 11668-11669 -RRB- denotes )
T19569 11670-11675 IN denotes after
T19570 11676-11679 DT denotes the
T19571 11680-11685 NN denotes start
T19572 11686-11688 IN denotes of
T19573 11689-11701 NN denotes transfection
T19574 11702-11705 IN denotes for
T19575 11706-11710 NN denotes IκBα
T19576 11711-11726 NN denotes phosphorylation
T19577 11727-11730 CC denotes and
T19578 11731-11742 NN denotes degradation
T19579 11742-11743 -COMMA- denotes ,
T19580 11744-11747 CC denotes and
T19581 11748-11752 NN denotes IRF3
T19582 11753-11768 NN denotes phosphorylation
T19583 11769-11771 IN denotes by
T19584 11772-11786 NN denotes immunoblotting
T19585 11787-11789 IN denotes of
T19586 11790-11795 JJ denotes total
T19587 11796-11800 NN denotes cell
T19588 11801-11809 NN denotes extracts
T19589 11810-11811 -LRB- denotes (
T19590 11811-11812 NN denotes B
T19591 11812-11813 -RRB- denotes )
T19592 11815-11818 DT denotes The
T19593 11819-11823 NN denotes band
T19594 11824-11828 WDT denotes that
T19595 11829-11831 VB denotes is
T19596 11832-11848 RB denotes non-specifically
T19597 11849-11859 VB denotes recognized
T19598 11860-11862 IN denotes by
T19599 11863-11866 DT denotes the
T19600 11867-11876 JJ denotes anti-IκBα
T19601 11877-11885 NN denotes antibody
T19602 11886-11887 -LRB- denotes (
T19603 11887-11896 VB denotes indicated
T19604 11897-11899 IN denotes by
T19605 11900-11902 DT denotes an
T19606 11903-11911 NN denotes asterisk
T19607 11911-11912 -RRB- denotes )
T19608 11913-11916 MD denotes can
T19609 11917-11919 VB denotes be
T19610 11920-11924 VB denotes used
T19611 11925-11927 IN denotes as
T19612 11928-11929 DT denotes a
T19613 11930-11937 NN denotes loading
T19614 11938-11945 NN denotes control
T19615 11947-11954 JJ denotes Nuclear
T19616 11955-11968 NN denotes translocation
T19617 11969-11971 IN denotes of
T19618 11972-11977 NN denotes NF-κB
T19619 11978-11979 -LRB- denotes (
T19620 11979-11982 NN denotes p65
T19621 11982-11983 -RRB- denotes )
T19622 11984-11987 CC denotes and
T19623 11988-11992 NN denotes IRF3
T19624 11993-11996 VB denotes was
T19625 11997-12005 VB denotes analyzed
T19626 12006-12008 IN denotes by
T19627 12009-12023 NN denotes immunoblotting
T19628 12024-12026 IN denotes of
T19629 12027-12038 JJ denotes cytoplasmic
T19630 12039-12041 CC denotes or
T19631 12042-12049 JJ denotes nuclear
T19632 12050-12059 NN denotes fractions
T19633 12060-12061 -LRB- denotes (
T19634 12061-12062 NN denotes C
T19635 12062-12063 -RRB- denotes )
T19636 12065-12079 NN denotes Quantification
T19637 12080-12082 IN denotes of
T19638 12083-12087 NN denotes band
T19639 12088-12095 NN denotes density
T19640 12096-12099 IN denotes for
T19641 12100-12107 JJ denotes nuclear
T19642 12108-12111 NN denotes p65
T19643 12112-12115 CC denotes and
T19644 12116-12120 NN denotes IRF3
T19645 12121-12123 VB denotes is
T19646 12124-12129 VB denotes shown
T19647 12130-12132 IN denotes in
T19648 12133-12136 NN denotes bar
T19649 12137-12143 NN denotes graphs
T19650 12144-12145 -LRB- denotes (
T19651 12145-12154 VB denotes expressed
T19652 12155-12157 IN denotes as
T19653 12158-12166 JJ denotes relative
T19654 12167-12174 NN denotes density
T19655 12175-12183 VB denotes compared
T19656 12184-12186 TO denotes to
T19657 12187-12190 DT denotes the
T19658 12191-12196 JJ denotes first
T19659 12197-12201 NN denotes lane
T19660 12201-12202 -COLON- denotes ;
T19661 12203-12210 RB denotes  = time
T19662 12211-12212 CD denotes 0
T19663 12212-12213 -RRB- denotes )
T19664 12215-12219 NN denotes IL-6
T19665 12219-12220 -COMMA- denotes ,
T19666 12221-12224 NN denotes TNF
T19667 12225-12228 CC denotes and
T19668 12229-12233 NN denotes IFNβ
T19669 12234-12240 NN denotes levels
T19670 12241-12243 IN denotes in
T19671 12244-12247 DT denotes the
T19672 12248-12259 NN denotes supernatant
T19673 12260-12262 IN denotes of
T19674 12263-12268 NN denotes cells
T19675 12269-12273 VB denotes used
T19676 12274-12276 IN denotes in
T19677 12277-12278 -LRB- denotes (
T19678 12278-12279 NN denotes B
T19679 12279-12280 -RRB- denotes )
T19680 12281-12285 VB denotes were
T19681 12286-12296 VB denotes determined
T19682 12297-12299 IN denotes by
T19683 12300-12308 NN denotes bioassay
T19684 12309-12310 -LRB- denotes (
T19685 12310-12314 NN denotes IL-6
T19686 12314-12315 -RRB- denotes )
T19687 12316-12319 CC denotes and
T19688 12320-12325 NN denotes ELISA
T19689 12326-12327 -LRB- denotes (
T19690 12327-12330 NN denotes TNF
T19691 12331-12334 CC denotes and
T19692 12335-12339 NN denotes IFNβ
T19693 12339-12340 -RRB- denotes )
T19694 12341-12343 IN denotes as
T19695 12344-12353 VB denotes described
T19696 12354-12356 IN denotes in
T19697 12357-12360 DT denotes the
T19698 12361-12371 NN denotes ‘materials
T19699 12372-12375 CC denotes and
T19700 12376-12384 NN denotes methods’
T19701 12385-12392 NN denotes section
T19702 12393-12394 -LRB- denotes (
T19703 12394-12395 NN denotes D
T19704 12395-12396 -RRB- denotes )
T19705 12398-12402 NN denotes Data
T19706 12403-12406 VB denotes are
T19707 12407-12421 JJ denotes representative
T19708 12422-12424 IN denotes of
T19709 12425-12426 CD denotes 2
T19710 12427-12438 JJ denotes independent
T19711 12439-12450 NN denotes experiments
T5355 12452-12454 TO denotes To
T5356 12455-12460 VB denotes study
T5357 12461-12464 DT denotes the
T5358 12465-12471 NN denotes effect
T5359 12472-12474 IN denotes of
T5360 12475-12487 RB denotes endogenously
T5361 12488-12497 VB denotes expressed
T5362 12498-12501 NN denotes A20
T5363 12502-12504 IN denotes on
T5364 12505-12518 JJ denotes RIG-I-induced
T5365 12519-12528 NN denotes signaling
T5366 12529-12531 IN denotes in
T5367 12532-12533 DT denotes a
T5368 12534-12538 RB denotes more
T5369 12539-12552 JJ denotes immunological
T5370 12553-12561 JJ denotes relevant
T5371 12562-12569 NN denotes context
T5372 12569-12570 -COMMA- denotes ,
T5373 12571-12573 PRP denotes we
T5374 12574-12583 VB denotes performed
T5375 12584-12591 JJ denotes further
T5376 12592-12603 NN denotes experiments
T5377 12604-12606 IN denotes in
T5378 12607-12610 NN denotes A20
T5379 12611-12620 JJ denotes deficient
T5380 12621-12628 JJ denotes primary
T5381 12629-12640 NN denotes macrophages
T5382 12642-12647 IN denotes Since
T5383 12648-12651 NN denotes A20
T5384 12652-12656 JJ denotes full
T5385 12657-12665 NN denotes knockout
T5386 12666-12670 NN denotes mice
T5387 12671-12674 VB denotes die
T5388 12675-12686 RB denotes prematurely
T5389 12687-12689 IN denotes as
T5390 12690-12691 DT denotes a
T5391 12692-12698 NN denotes result
T5392 12699-12701 IN denotes of
T5393 12702-12708 JJ denotes severe
T5394 12709-12720 JJ denotes multi-organ
T5395 12721-12733 NN denotes inflammation
T5396 12734-12735 -LRB- denotes [
T5397 12735-12737 CD denotes 37
T5398 12737-12738 -RRB- denotes ]
T5399 12738-12739 -COMMA- denotes ,
T5400 12740-12742 PRP denotes we
T5401 12743-12752 VB denotes generated
T5402 12753-12757 NN denotes mice
T5403 12758-12766 VB denotes carrying
T5404 12767-12768 DT denotes a
T5405 12769-12780 JJ denotes conditional
T5406 12781-12784 NN denotes A20
T5407 12785-12791 NN denotes allele
T5408 12792-12794 IN denotes in
T5409 12795-12800 WDT denotes which
T5410 12801-12805 NN denotes exon
T5411 12806-12808 CD denotes IV
T5412 12809-12812 CC denotes and
T5413 12813-12817 NN denotes exon
T5414 12818-12819 CD denotes V
T5415 12820-12824 VB denotes were
T5416 12825-12832 VB denotes flanked
T5417 12833-12835 IN denotes by
T5418 12836-12839 CD denotes two
T5419 12840-12844 NN denotes loxP
T5420 12845-12850 NN denotes sites
T5421 12851-12852 -LRB- denotes [
T5422 12852-12854 CD denotes 56
T5423 12854-12855 -RRB- denotes ]
T5424 12857-12865 VB denotes Crossing
T5425 12866-12871 DT denotes these
T5426 12872-12876 NN denotes mice
T5427 12877-12881 IN denotes with
T5428 12882-12892 JJ denotes transgenic
T5429 12893-12897 NN denotes mice
T5430 12898-12908 VB denotes expressing
T5431 12909-12912 NNP denotes Cre
T5432 12913-12924 NN denotes recombinase
T5433 12925-12930 IN denotes under
T5434 12931-12938 NN denotes control
T5435 12939-12941 IN denotes of
T5436 12942-12945 DT denotes the
T5437 12946-12954 NN denotes lysozyme
T5438 12955-12956 NN denotes M
T5439 12957-12965 NN denotes promoter
T5440 12966-12971 VB denotes leads
T5441 12972-12974 TO denotes to
T5442 12975-12983 JJ denotes specific
T5443 12984-12992 NN denotes deletion
T5444 12993-12995 IN denotes in
T5445 12996-13003 JJ denotes myeloid
T5446 13004-13009 NN denotes cells
T5447 13010-13013 CC denotes and
T5448 13014-13021 VB denotes allowed
T5449 13022-13024 PRP denotes us
T5450 13025-13027 TO denotes to
T5451 13028-13036 VB denotes generate
T5452 13037-13044 JJ denotes myeloid
T5453 13045-13049 NN denotes cell
T5454 13050-13058 JJ denotes specific
T5455 13059-13062 NN denotes A20
T5456 13063-13071 NN denotes knockout
T5457 13072-13076 NN denotes mice
T5458 13077-13078 -LRB- denotes [
T5459 13078-13080 CD denotes 48
T5460 13080-13081 -RRB- denotes ]
T5461 13083-13085 TO denotes To
T5462 13086-13095 VB denotes stimulate
T5463 13096-13099 DT denotes the
T5464 13100-13105 NN denotes RIG-I
T5465 13106-13114 NN denotes receptor
T5466 13114-13115 -COMMA- denotes ,
T5467 13116-13118 PRP denotes we
T5468 13119-13130 VB denotes transfected
T5469 13131-13141 NN denotes A20myel-KO
T5470 13142-13146 NN denotes BMDM
T5471 13147-13150 CC denotes and
T5472 13151-13155 JJ denotes wild
T5473 13156-13160 NN denotes type
T5474 13161-13168 NN denotes control
T5475 13169-13174 NN denotes cells
T5476 13175-13179 IN denotes with
T5477 13180-13187 JJ denotes minimal
T5478 13188-13195 NN denotes amounts
T5479 13196-13198 IN denotes of
T5480 13199-13202 JJ denotes low
T5481 13203-13212 JJ denotes molecular
T5482 13213-13219 NN denotes weight
T5483 13220-13221 -LRB- denotes (
T5484 13221-13224 NN denotes LMW
T5485 13224-13225 -RRB- denotes )
T5486 13226-13230 NN denotes poly
T5487 13230-13231 -LRB- denotes (
T5488 13231-13232 NN denotes I
T5489 13232-13233 SYM denotes :
T5490 13233-13234 NN denotes C
T5491 13234-13235 -RRB- denotes )
T5492 13235-13236 -COMMA- denotes ,
T5493 13237-13242 WDT denotes which
T5494 13243-13245 VB denotes is
T5495 13246-13251 VB denotes known
T5496 13252-13254 TO denotes to
T5497 13255-13269 RB denotes preferentially
T5498 13270-13274 VB denotes bind
T5499 13275-13278 CC denotes and
T5500 13279-13287 VB denotes activate
T5501 13288-13293 NN denotes RIG-I
T5502 13294-13300 RB denotes rather
T5503 13301-13305 IN denotes than
T5504 13306-13310 NN denotes MDA5
T5505 13311-13312 -LRB- denotes [
T5506 13312-13314 CD denotes 57
T5507 13314-13315 -RRB- denotes ]
T5508 13317-13319 IN denotes Of
T5509 13320-13324 NN denotes note
T5510 13324-13325 -COMMA- denotes ,
T5511 13326-13330 DT denotes this
T5512 13331-13344 NN denotes concentration
T5513 13345-13347 IN denotes of
T5514 13348-13352 NN denotes poly
T5515 13352-13353 -LRB- denotes (
T5516 13353-13354 NN denotes I
T5517 13354-13355 SYM denotes :
T5518 13355-13356 NN denotes C
T5519 13356-13357 -RRB- denotes )
T5520 13358-13361 VB denotes was
T5521 13362-13368 JJ denotes unable
T5522 13369-13371 TO denotes to
T5523 13372-13378 VB denotes induce
T5524 13379-13390 JJ denotes significant
T5525 13391-13395 NN denotes TLR3
T5526 13396-13405 JJ denotes dependent
T5527 13406-13411 NN denotes NF-κB
T5528 13412-13415 CC denotes and
T5529 13416-13420 NN denotes IRF3
T5530 13421-13431 NN denotes activation
T5531 13432-13434 CC denotes or
T5532 13435-13443 NN denotes cytokine
T5533 13444-13454 NN denotes production
T5534 13455-13456 -LRB- denotes (
T5535 13456-13460 NN denotes data
T5536 13461-13464 RB denotes not
T5537 13465-13470 VB denotes shown
T5538 13470-13471 -RRB- denotes )
T5539 13473-13475 IN denotes As
T5540 13476-13484 VB denotes expected
T5541 13484-13485 -COMMA- denotes ,
T5542 13486-13490 NN denotes poly
T5543 13490-13491 -LRB- denotes (
T5544 13491-13492 NN denotes I
T5545 13492-13493 SYM denotes :
T5546 13493-13494 NN denotes C
T5547 13494-13495 -RRB- denotes )
T5548 13496-13508 NN denotes transfection
T5549 13509-13516 VB denotes induced
T5550 13517-13520 DT denotes the
T5551 13521-13526 JJ denotes rapid
T5552 13527-13537 NN denotes expression
T5553 13538-13540 IN denotes of
T5554 13541-13544 NN denotes A20
T5555 13545-13547 IN denotes in
T5556 13548-13552 JJ denotes wild
T5557 13553-13557 NN denotes type
T5558 13557-13558 -COMMA- denotes ,
T5559 13559-13562 CC denotes but
T5560 13563-13566 RB denotes not
T5561 13567-13569 IN denotes in
T5562 13570-13580 NN denotes A20myel-KO
T5563 13581-13585 NN denotes BMDM
T5564 13586-13587 -LRB- denotes (
T5565 13587-13593 NN denotes figure
T5566 13594-13596 NN denotes 1B
T5567 13596-13597 -COMMA- denotes ,
T5568 13598-13603 JJ denotes upper
T5569 13604-13609 NN denotes panel
T5570 13609-13610 -RRB- denotes )
T5571 13612-13614 IN denotes At
T5572 13615-13620 JJ denotes early
T5573 13621-13625 NN denotes time
T5574 13626-13632 NN denotes points
T5575 13632-13633 -COMMA- denotes ,
T5576 13634-13642 RB denotes slightly
T5577 13643-13649 JJ denotes slower
T5578 13650-13659 JJ denotes migrating
T5579 13660-13665 NN denotes forms
T5580 13666-13668 IN denotes of
T5581 13669-13672 NN denotes A20
T5582 13673-13677 VB denotes were
T5583 13678-13686 VB denotes observed
T5584 13686-13687 -COMMA- denotes ,
T5585 13688-13698 VB denotes indicating
T5586 13699-13703 IN denotes that
T5587 13704-13707 NN denotes A20
T5588 13708-13717 VB denotes undergoes
T5589 13718-13719 DT denotes a
T5590 13720-13723 RB denotes yet
T5591 13724-13731 JJ denotes unknown
T5592 13732-13744 NN denotes modification
T5593 13745-13749 IN denotes upon
T5594 13750-13754 NN denotes poly
T5595 13754-13755 -LRB- denotes (
T5596 13755-13756 NN denotes I
T5597 13756-13757 SYM denotes :
T5598 13757-13758 NN denotes C
T5599 13758-13759 -RRB- denotes )
T5600 13760-13772 NN denotes transfection
T5601 13774-13782 VB denotes Compared
T5602 13783-13785 TO denotes to
T5603 13786-13790 JJ denotes wild
T5604 13791-13795 NN denotes type
T5605 13796-13800 NN denotes BMBM
T5606 13800-13801 -COMMA- denotes ,
T5607 13802-13805 NN denotes A20
T5608 13806-13815 JJ denotes deficient
T5609 13816-13821 NN denotes cells
T5610 13822-13828 VB denotes showed
T5611 13829-13837 VB denotes enhanced
T5612 13838-13843 NN denotes NF-κB
T5613 13844-13854 NN denotes activation
T5614 13855-13857 IN denotes as
T5615 13858-13867 VB denotes indicated
T5616 13868-13870 IN denotes by
T5617 13871-13880 VB denotes increased
T5618 13881-13896 NN denotes phosphorylation
T5619 13897-13900 CC denotes and
T5620 13901-13910 JJ denotes sustained
T5621 13911-13922 NN denotes degradation
T5622 13923-13925 IN denotes of
T5623 13926-13930 NN denotes IκBα
T5624 13931-13932 -LRB- denotes (
T5625 13932-13938 NN denotes figure
T5626 13939-13941 NN denotes 1B
T5627 13941-13942 -RRB- denotes )
T5628 13944-13955 RB denotes Furthermore
T5629 13955-13956 -COMMA- denotes ,
T5630 13957-13964 JJ denotes nuclear
T5631 13965-13978 NN denotes translocation
T5632 13979-13981 IN denotes of
T5633 13982-13985 DT denotes the
T5634 13986-13989 NN denotes p65
T5635 13990-13995 NN denotes NF-κB
T5636 13996-14003 NN denotes subunit
T5637 14004-14007 VB denotes was
T5638 14008-14016 VB denotes enhanced
T5639 14017-14019 IN denotes in
T5640 14020-14024 NN denotes poly
T5641 14024-14025 -LRB- denotes (
T5642 14025-14026 NN denotes I
T5643 14026-14027 SYM denotes :
T5644 14027-14028 NN denotes C
T5645 14028-14029 -RRB- denotes )
T5646 14030-14041 VB denotes transfected
T5647 14042-14052 NN denotes A20myel-KO
T5648 14053-14057 NN denotes BMDM
T5649 14057-14058 -COMMA- denotes ,
T5650 14059-14067 VB denotes reaching
T5651 14068-14069 DT denotes a
T5652 14070-14077 NN denotes maximum
T5653 14078-14080 IN denotes at
T5654 14081-14088 JJ denotes earlier
T5655 14089-14093 NN denotes time
T5656 14094-14100 NN denotes points
T5657 14101-14109 VB denotes compared
T5658 14110-14112 TO denotes to
T5659 14113-14117 JJ denotes wild
T5660 14118-14122 NN denotes type
T5661 14123-14128 NN denotes cells
T5662 14129-14130 -LRB- denotes (
T5663 14130-14136 NN denotes figure
T5664 14137-14139 NN denotes 1C
T5665 14139-14140 -RRB- denotes )
T5666 14142-14146 NN denotes IRF3
T5667 14147-14149 VB denotes is
T5668 14150-14155 VB denotes known
T5669 14156-14158 TO denotes to
T5670 14159-14161 VB denotes be
T5671 14162-14171 VB denotes activated
T5672 14172-14176 IN denotes upon
T5673 14177-14192 NN denotes phosphorylation
T5674 14193-14195 IN denotes of
T5675 14196-14197 DT denotes a
T5676 14198-14204 NN denotes series
T5677 14205-14207 IN denotes of
T5678 14208-14216 NN denotes carboxyl
T5679 14217-14225 JJ denotes terminal
T5680 14226-14232 NN denotes serine
T5681 14233-14241 NN denotes residues
T5682 14242-14244 IN denotes by
T5683 14245-14248 DT denotes the
T5684 14249-14257 JJ denotes IKK-like
T5685 14258-14265 NN denotes kinases
T5686 14266-14270 NN denotes TBK1
T5687 14271-14274 CC denotes and
T5688 14275-14279 NN denotes IKKε
T5689 14280-14281 -LRB- denotes [
T5690 14281-14283 CD denotes 58
T5691 14283-14284 -RRB- denotes ]
T5692 14284-14285 -COMMA- denotes ,
T5693 14286-14293 VB denotes leading
T5694 14294-14296 TO denotes to
T5695 14297-14300 PRP-DOLLAR- denotes its
T5696 14301-14313 NN denotes dimerization
T5697 14314-14317 CC denotes and
T5698 14318-14328 JJ denotes subsequent
T5699 14329-14342 NN denotes translocation
T5700 14343-14345 TO denotes to
T5701 14346-14349 DT denotes the
T5702 14350-14357 NN denotes nucleus
T5703 14358-14359 -LRB- denotes [
T5704 14359-14361 CD denotes 59
T5705 14361-14362 -RRB- denotes ]
T5706 14364-14369 VB denotes Using
T5707 14370-14384 NN denotes immunoblotting
T5708 14385-14389 IN denotes with
T5709 14390-14392 DT denotes an
T5710 14393-14401 NN denotes antibody
T5711 14402-14410 VB denotes directed
T5712 14411-14418 IN denotes against
T5713 14419-14433 VB denotes phosphorylated
T5714 14434-14440 NN denotes Ser396
T5715 14440-14441 -COMMA- denotes ,
T5716 14442-14449 JJ denotes maximum
T5717 14450-14454 NN denotes IRF3
T5718 14455-14470 NN denotes phosphorylation
T5719 14471-14474 VB denotes was
T5720 14475-14483 VB denotes detected
T5721 14484-14486 IN denotes at
T5722 14487-14494 JJ denotes earlier
T5723 14495-14499 NN denotes time
T5724 14500-14506 NN denotes points
T5725 14507-14509 IN denotes in
T5726 14510-14520 NN denotes A20myel-KO
T5727 14521-14525 NN denotes BMDM
T5728 14526-14534 VB denotes compared
T5729 14535-14537 TO denotes to
T5730 14538-14542 JJ denotes wild
T5731 14543-14547 NN denotes type
T5732 14548-14552 NN denotes BMDM
T5733 14553-14554 -LRB- denotes (
T5734 14554-14560 NN denotes figure
T5735 14561-14563 NN denotes 1B
T5736 14563-14564 -RRB- denotes )
T5737 14566-14573 JJ denotes Similar
T5738 14574-14576 TO denotes to
T5739 14577-14580 NN denotes p65
T5740 14580-14581 -COMMA- denotes ,
T5741 14582-14586 NN denotes IRF3
T5742 14587-14594 JJ denotes nuclear
T5743 14595-14608 NN denotes translocation
T5744 14609-14616 VB denotes reached
T5745 14617-14620 PRP-DOLLAR- denotes its
T5746 14621-14628 NN denotes maximum
T5747 14629-14631 IN denotes at
T5748 14632-14634 DT denotes an
T5749 14635-14642 JJ denotes earlier
T5750 14643-14647 NN denotes time
T5751 14648-14653 NN denotes point
T5752 14654-14656 IN denotes in
T5753 14657-14660 NN denotes A20
T5754 14661-14670 JJ denotes deficient
T5755 14671-14675 NN denotes BMDM
T5756 14676-14684 VB denotes compared
T5757 14685-14687 TO denotes to
T5758 14688-14692 JJ denotes wild
T5759 14693-14697 NN denotes type
T5760 14698-14703 NN denotes cells
T5761 14704-14705 -LRB- denotes (
T5762 14705-14711 NN denotes figure
T5763 14712-14714 NN denotes 1C
T5764 14714-14715 -RRB- denotes )
T5765 14717-14722 NN denotes NF-κB
T5766 14723-14731 VB denotes controls
T5767 14732-14735 DT denotes the
T5768 14736-14746 NN denotes expression
T5769 14747-14749 IN denotes of
T5770 14750-14754 NN denotes IL-6
T5771 14755-14758 CC denotes and
T5772 14759-14762 NN denotes TNF
T5773 14762-14763 -COMMA- denotes ,
T5774 14764-14767 CC denotes and
T5775 14768-14773 NN denotes NF-κB
T5776 14774-14777 CC denotes and
T5777 14778-14782 NN denotes IRF3
T5778 14783-14790 VB denotes control
T5779 14791-14794 DT denotes the
T5780 14795-14805 NN denotes expression
T5781 14806-14808 IN denotes of
T5782 14809-14813 NN denotes IFNβ
T5783 14815-14817 IN denotes In
T5784 14818-14822 NN denotes line
T5785 14823-14827 IN denotes with
T5786 14828-14831 DT denotes the
T5787 14832-14840 VB denotes enhanced
T5788 14841-14851 NN denotes activation
T5789 14852-14854 IN denotes of
T5790 14855-14860 NN denotes NF-κB
T5791 14861-14864 CC denotes and
T5792 14865-14869 NN denotes IRF3
T5793 14870-14872 IN denotes as
T5794 14873-14882 VB denotes described
T5795 14883-14888 IN denotes above
T5796 14888-14889 -COMMA- denotes ,
T5797 14890-14900 NN denotes A20myel-KO
T5798 14901-14905 NN denotes BMDM
T5799 14906-14914 VB denotes secreted
T5800 14915-14924 VB denotes increased
T5801 14925-14932 NN denotes amounts
T5802 14933-14935 IN denotes of
T5803 14936-14940 NN denotes IL-6
T5804 14940-14941 -COMMA- denotes ,
T5805 14942-14945 NN denotes TNF
T5806 14946-14949 CC denotes and
T5807 14950-14954 NN denotes IFNβ
T5808 14955-14956 -LRB- denotes (
T5809 14956-14962 NN denotes figure
T5810 14963-14965 NN denotes 1D
T5811 14965-14966 -RRB- denotes )
T5812 14968-14975 JJ denotes Similar
T5813 14976-14983 NN denotes results
T5814 14984-14988 VB denotes were
T5815 14989-14997 VB denotes obtained
T5816 14998-15003 VB denotes using
T5817 15004-15014 JJ denotes peritoneal
T5818 15015-15026 NN denotes macrophages
T5819 15027-15028 -LRB- denotes (
T5820 15028-15032 NN denotes data
T5821 15033-15036 RB denotes not
T5822 15037-15042 VB denotes shown
T5823 15042-15043 -RRB- denotes )
T5824 15045-15053 RB denotes Together
T5825 15053-15054 -COMMA- denotes ,
T5826 15055-15060 DT denotes these
T5827 15061-15068 NN denotes results
T5828 15069-15080 VB denotes demonstrate
T5829 15081-15085 IN denotes that
T5830 15086-15089 NN denotes A20
T5831 15090-15095 VB denotes plays
T5832 15096-15098 DT denotes an
T5833 15099-15108 JJ denotes important
T5834 15109-15113 NN denotes role
T5835 15114-15116 IN denotes in
T5836 15117-15120 DT denotes the
T5837 15121-15129 JJ denotes negative
T5838 15130-15140 NN denotes regulation
T5839 15141-15143 IN denotes of
T5840 15144-15157 JJ denotes RIG-I-induced
T5841 15158-15163 NN denotes NF-κB
T5842 15164-15167 CC denotes and
T5843 15168-15172 NN denotes IRF3
T5844 15173-15183 NN denotes activation
T5845 15184-15186 IN denotes in
T5846 15187-15194 JJ denotes primary
T5847 15195-15206 NN denotes macrophages
T7810 15209-15212 NN denotes A20
T7811 15213-15223 RB denotes negatively
T7812 15224-15233 VB denotes regulates
T7813 15234-15245 JJ denotes IAV-induced
T7814 15246-15250 NN denotes gene
T7815 15251-15261 NN denotes expression
T7816 15262-15264 IN denotes in
T7817 15265-15269 NN denotes BMDM
T7818 15270-15272 TO denotes To
T7819 15273-15284 VB denotes investigate
T7820 15285-15288 DT denotes the
T7821 15289-15293 NN denotes role
T7822 15294-15296 IN denotes of
T7823 15297-15300 NN denotes A20
T7824 15301-15303 IN denotes in
T7825 15304-15307 DT denotes the
T7826 15308-15319 JJ denotes IAV-induced
T7827 15320-15335 JJ denotes proinflammatory
T7828 15336-15339 CC denotes and
T7829 15340-15349 JJ denotes antiviral
T7830 15350-15356 JJ denotes innate
T7831 15357-15363 JJ denotes immune
T7832 15364-15373 NN denotes responses
T7833 15373-15374 -COMMA- denotes ,
T7834 15375-15377 PRP denotes we
T7835 15378-15386 VB denotes infected
T7836 15387-15390 NN denotes A20
T7837 15391-15400 JJ denotes deficient
T7838 15401-15404 CC denotes and
T7839 15405-15412 NN denotes control
T7840 15413-15417 NN denotes BMDM
T7841 15418-15422 IN denotes with
T7842 15423-15426 NN denotes IAV
T7843 15427-15431 NN denotes X-47
T7844 15432-15433 -LRB- denotes (
T7845 15433-15437 NN denotes H3N2
T7846 15437-15438 -RRB- denotes )
T7847 15440-15443 NN denotes A20
T7848 15444-15448 NN denotes mRNA
T7849 15449-15455 NN denotes levels
T7850 15456-15460 VB denotes were
T7851 15461-15468 RB denotes rapidly
T7852 15469-15476 VB denotes induced
T7853 15477-15479 IN denotes in
T7854 15480-15484 JJ denotes wild
T7855 15485-15489 NN denotes type
T7856 15490-15494 NN denotes BMDM
T7857 15494-15495 -COMMA- denotes ,
T7858 15496-15499 CC denotes but
T7859 15500-15503 RB denotes not
T7860 15504-15506 IN denotes in
T7861 15507-15510 NN denotes A20
T7862 15511-15520 JJ denotes deficient
T7863 15521-15525 NN denotes BMDM
T7864 15525-15526 -COMMA- denotes ,
T7865 15527-15531 IN denotes upon
T7866 15532-15537 JJ denotes viral
T7867 15538-15547 NN denotes infection
T7868 15548-15549 -LRB- denotes (
T7869 15549-15555 NN denotes figure
T7870 15556-15558 NN denotes 2A
T7871 15558-15559 -RRB- denotes )
T7872 15561-15572 RB denotes Furthermore
T7873 15572-15573 -COMMA- denotes ,
T7874 15574-15584 NN denotes A20myel-KO
T7875 15585-15589 NN denotes BMDM
T7876 15590-15594 VB denotes show
T7877 15595-15603 VB denotes enhanced
T7878 15604-15614 NN denotes expression
T7879 15615-15617 IN denotes of
T7880 15618-15622 NN denotes IL-6
T7881 15623-15626 CC denotes and
T7882 15627-15631 NN denotes IFNβ
T7883 15632-15636 NN denotes mRNA
T7884 15637-15642 IN denotes after
T7885 15643-15646 NN denotes IAV
T7886 15647-15656 NN denotes infection
T7887 15657-15665 VB denotes compared
T7888 15666-15668 TO denotes to
T7889 15669-15676 NN denotes control
T7890 15677-15682 NN denotes cells
T7891 15683-15684 -LRB- denotes (
T7892 15684-15690 NN denotes figure
T7893 15691-15693 NN denotes 2A
T7894 15693-15694 -RRB- denotes )
T7895 15696-15698 IN denotes In
T7896 15699-15709 NN denotes accordance
T7897 15710-15714 IN denotes with
T7898 15715-15720 DT denotes these
T7899 15721-15725 NN denotes data
T7900 15725-15726 -COMMA- denotes ,
T7901 15727-15731 NN denotes cell
T7902 15732-15739 NN denotes culture
T7903 15740-15751 NN denotes supernatant
T7904 15752-15761 VB denotes collected
T7905 15762-15766 IN denotes from
T7906 15767-15772 DT denotes these
T7907 15773-15778 NN denotes cells
T7908 15779-15788 VB denotes contained
T7909 15789-15795 JJ denotes higher
T7910 15796-15802 NN denotes levels
T7911 15803-15805 IN denotes of
T7912 15806-15809 NN denotes TNF
T7913 15810-15813 CC denotes and
T7914 15814-15818 NN denotes IFNβ
T7915 15819-15820 -LRB- denotes (
T7916 15820-15826 NN denotes figure
T7917 15827-15829 NN denotes 2B
T7918 15829-15830 -RRB- denotes )
T20324 15876-15879 NN denotes A20
T20325 15880-15890 RB denotes negatively
T20326 15891-15900 VB denotes regulates
T20327 15901-15912 JJ denotes IAV-induced
T20328 15913-15917 NN denotes gene
T20329 15918-15928 NN denotes expression
T20330 15929-15931 IN denotes in
T20331 15932-15936 NN denotes BMDM
T20332 15937-15940 CC denotes and
T20333 15941-15949 JJ denotes alveolar
T20334 15950-15961 NN denotes macrophages
T20335 15963-15964 -LRB- denotes (
T20336 15964-15967 NN denotes A–B
T20337 15967-15968 -RRB- denotes )
T20338 15969-15973 NN denotes BMDM
T20339 15974-15982 VB denotes isolated
T20340 15983-15987 IN denotes from
T20341 15988-15998 NN denotes A20myel-WT
T20342 15999-16002 CC denotes and
T20343 16003-16013 NN denotes A20myel-KO
T20344 16014-16021 NN denotes animals
T20345 16022-16026 VB denotes were
T20346 16027-16035 VB denotes infected
T20347 16036-16040 IN denotes with
T20348 16041-16044 NN denotes IAV
T20349 16045-16046 -LRB- denotes (
T20350 16046-16049 NN denotes moi
T20351 16050-16051 CD denotes 1
T20352 16051-16052 -RRB- denotes )
T20353 16054-16056 IN denotes At
T20354 16057-16066 JJ denotes different
T20355 16067-16072 NN denotes hours
T20356 16073-16077 NN denotes post
T20357 16078-16087 NN denotes infection
T20358 16088-16089 -LRB- denotes (
T20359 16089-16094 NN denotes hours
T20360 16095-16099 NN denotes p.i.
T20361 16099-16100 -RRB- denotes )
T20362 16101-16106 NN denotes cells
T20363 16107-16111 VB denotes were
T20364 16112-16117 VB denotes lysed
T20365 16118-16121 CC denotes and
T20366 16122-16126 NN denotes IL-6
T20367 16126-16127 -COMMA- denotes ,
T20368 16128-16132 NN denotes IFNβ
T20369 16133-16136 CC denotes and
T20370 16137-16140 NN denotes A20
T20371 16141-16145 NN denotes mRNA
T20372 16146-16156 NN denotes expression
T20373 16157-16160 VB denotes was
T20374 16161-16169 VB denotes analyzed
T20375 16170-16172 IN denotes by
T20376 16173-16177 NN denotes qPCR
T20377 16178-16179 -LRB- denotes (
T20378 16179-16180 NN denotes A
T20379 16180-16181 -RRB- denotes )
T20380 16183-16185 CD denotes 18
T20381 16186-16191 NN denotes hours
T20382 16192-16196 VB denotes post
T20383 16197-16206 NN denotes infection
T20384 16207-16211 NN denotes cell
T20385 16212-16219 NN denotes culture
T20386 16220-16231 NN denotes supernatant
T20387 16232-16235 VB denotes was
T20388 16236-16244 VB denotes analyzed
T20389 16245-16248 IN denotes for
T20390 16249-16252 NN denotes TNF
T20391 16253-16256 CC denotes and
T20392 16257-16261 NN denotes IFNβ
T20393 16262-16269 NN denotes protein
T20394 16270-16276 NN denotes levels
T20395 16277-16279 IN denotes by
T20396 16280-16285 NN denotes ELISA
T20397 16286-16289 CC denotes and
T20398 16290-16302 JJ denotes multiplexing
T20399 16303-16315 NN denotes technologies
T20400 16316-16317 -LRB- denotes (
T20401 16317-16318 NN denotes B
T20402 16318-16319 -RRB- denotes )
T20403 16319-16320 -LRB- denotes .
T20404 16321-16324 NN denotes (C–
T20405 16324-16325 -RRB- denotes D
T20406 16325-16333 JJ denotes ) Alveol
T20407 16333-16344 NN denotes ar macropha
T20408 16344-16348 VB denotes ges
T20409 16348-16352 JJ denotes were
T20410 16353-16360 VB denotes mock tr
T20411 16360-16362 CC denotes ea
T20412 16362-16370 VB denotes ted or i
T20413 16370-16374 IN denotes nfec
T20414 16374-16377 NN denotes ted
T20415 16378-16379 -LRB- denotes w
T20416 16379-16382 NN denotes ith
T20417 16383-16384 CD denotes I
T20418 16384-16385 -RRB- denotes A
T20419 16385-16388 IN denotes V (
T20420 16388-16390 CD denotes mo
T20421 16390-16395 NN denotes i 1)
T20422 16409-16413 NN denotes IL-6
T20423 16414-16417 CC denotes and
T20424 16418-16422 NN denotes IFNβ
T20425 16423-16427 NN denotes mRNA
T20426 16428-16438 NN denotes expression
T20427 16439-16442 VB denotes was
T20428 16443-16453 VB denotes determined
T20429 16454-16456 IN denotes by
T20430 16457-16461 NN denotes qPCR
T20431 16462-16463 -LRB- denotes (
T20432 16463-16464 NN denotes C
T20433 16464-16465 -RRB- denotes )
T20434 16467-16471 NN denotes Cell
T20435 16472-16479 NN denotes culture
T20436 16480-16491 NN denotes supernatant
T20437 16492-16495 VB denotes was
T20438 16496-16504 VB denotes analyzed
T20439 16505-16508 IN denotes for
T20440 16509-16513 NN denotes IL-6
T20441 16514-16517 CC denotes and
T20442 16518-16522 NN denotes IFNβ
T20443 16523-16530 NN denotes protein
T20444 16531-16537 NN denotes levels
T20445 16538-16540 IN denotes by
T20446 16541-16546 NN denotes ELISA
T20447 16547-16550 CC denotes and
T20448 16551-16563 JJ denotes multiplexing
T20449 16564-16576 NN denotes technologies
T20450 16577-16578 -LRB- denotes (
T20451 16578-16579 NN denotes D
T20452 16579-16580 -RRB- denotes )
T20453 16582-16587 NN denotes Error
T20454 16588-16592 NN denotes bars
T20455 16593-16602 VB denotes represent
T20456 16603-16607 JJ denotes mean
T20457 16608-16614 NN denotes values
T20458 16615-16616 -LRB- denotes (
T20459 16616-16619 CC denotes +/−
T20460 16620-16623 NN denotes SEM
T20461 16623-16624 -RRB- denotes )
T20462 16625-16627 IN denotes of
T20463 16628-16631 CD denotes 2–3
T20464 16632-16639 NN denotes samples
T20465 16641-16648 NN denotes Results
T20466 16649-16652 VB denotes are
T20467 16653-16667 JJ denotes representative
T20468 16668-16671 IN denotes for
T20469 16672-16673 CD denotes 2
T20470 16674-16685 JJ denotes independent
T20471 16686-16698 NN denotes experiments.
T20472 16699-16703 NN denotes ***p
T20473 16703-16704 SYM denotes <
T20474 16704-16709 CD denotes 0,001
T7919 16711-16715 IN denotes Upon
T7920 16716-16720 NN denotes host
T7921 16721-16730 NN denotes infection
T7922 16731-16735 IN denotes with
T7923 16736-16739 NN denotes IAV
T7924 16739-16740 -COMMA- denotes ,
T7925 16741-16749 JJ denotes alveolar
T7926 16750-16761 NN denotes macrophages
T7927 16762-16765 VB denotes are
T7928 16766-16768 DT denotes an
T7929 16769-16778 JJ denotes important
T7930 16779-16785 NN denotes source
T7931 16786-16788 IN denotes of
T7932 16789-16798 NN denotes cytokines
T7933 16799-16802 CC denotes and
T7934 16803-16813 NN denotes chemokines
T7935 16813-16814 -COMMA- denotes ,
T7936 16815-16825 VB denotes attracting
T7937 16826-16832 JJ denotes innate
T7938 16833-16839 JJ denotes immune
T7939 16840-16845 NN denotes cells
T7940 16846-16848 TO denotes to
T7941 16849-16852 DT denotes the
T7942 16853-16857 NN denotes lung
T7943 16858-16864 IN denotes during
T7944 16865-16868 DT denotes the
T7945 16869-16876 JJ denotes primary
T7946 16877-16882 NN denotes phase
T7947 16883-16885 IN denotes of
T7948 16886-16895 NN denotes infection
T7949 16897-16899 TO denotes To
T7950 16900-16904 VB denotes test
T7951 16905-16912 IN denotes whether
T7952 16913-16916 NN denotes A20
T7953 16917-16925 RB denotes directly
T7954 16926-16934 VB denotes controls
T7955 16935-16946 JJ denotes IAV-induced
T7956 16947-16951 NN denotes gene
T7957 16952-16962 NN denotes expression
T7958 16963-16965 IN denotes in
T7959 16966-16974 JJ denotes alveolar
T7960 16975-16986 NN denotes macrophages
T7961 16986-16987 -COMMA- denotes ,
T7962 16988-16990 PRP denotes we
T7963 16991-16999 VB denotes isolated
T7964 17000-17005 DT denotes these
T7965 17006-17011 NN denotes cells
T7966 17012-17016 IN denotes from
T7967 17017-17022 NN denotes lungs
T7968 17023-17025 IN denotes of
T7969 17026-17036 NN denotes A20myel-KO
T7970 17037-17040 CC denotes and
T7971 17041-17048 NN denotes control
T7972 17049-17060 NN denotes littermates
T7973 17061-17064 CC denotes and
T7974 17065-17073 VB denotes infected
T7975 17074-17078 PRP denotes them
T7976 17079-17081 FW denotes in
T7977 17082-17087 FW denotes vitro
T7978 17088-17092 IN denotes with
T7979 17093-17096 NN denotes IAV
T7980 17097-17101 NN denotes X-47
T7981 17103-17113 NN denotes Expression
T7982 17114-17117 CC denotes and
T7983 17118-17127 NN denotes secretion
T7984 17128-17130 IN denotes of
T7985 17131-17134 DT denotes the
T7986 17135-17150 JJ denotes proinflammatory
T7987 17151-17160 NN denotes cytokines
T7988 17161-17165 NN denotes IL-6
T7989 17166-17169 CC denotes and
T7990 17170-17173 NN denotes TNF
T7991 17173-17174 -COMMA- denotes ,
T7992 17175-17178 DT denotes the
T7993 17179-17185 NN denotes type-I
T7994 17186-17189 NN denotes IFN
T7995 17190-17194 NN denotes IFNβ
T7996 17195-17198 CC denotes and
T7997 17199-17204 NN denotes IFNα4
T7998 17205-17208 CC denotes and
T7999 17209-17212 DT denotes the
T8000 17213-17223 NN denotes chemokines
T8001 17224-17229 NN denotes MCP-1
T8002 17230-17231 -LRB- denotes (
T8003 17231-17235 NN denotes ccl2
T8004 17235-17236 -RRB- denotes )
T8005 17237-17240 CC denotes and
T8006 17241-17243 NN denotes KC
T8007 17244-17245 -LRB- denotes (
T8008 17245-17250 NN denotes cxcl1
T8009 17250-17251 -RRB- denotes )
T8010 17252-17255 VB denotes was
T8011 17256-17269 RB denotes significantly
T8012 17270-17276 JJ denotes higher
T8013 17277-17279 IN denotes in
T8014 17280-17283 NN denotes IAV
T8015 17284-17292 JJ denotes infected
T8016 17293-17298 NN denotes cells
T8017 17299-17306 VB denotes lacking
T8018 17307-17310 NN denotes A20
T8019 17311-17319 VB denotes compared
T8020 17320-17322 TO denotes to
T8021 17323-17331 JJ denotes infected
T8022 17332-17336 JJ denotes wild
T8023 17337-17341 NN denotes type
T8024 17342-17347 NN denotes cells
T8025 17348-17349 -LRB- denotes (
T8026 17349-17355 NN denotes figure
T8027 17356-17358 NN denotes 2C
T8028 17359-17362 CC denotes and
T8029 17363-17369 NN denotes figure
T8030 17370-17372 NN denotes S1
T8031 17372-17373 -RRB- denotes )
T8032 17375-17380 VB denotes Taken
T8033 17381-17389 RB denotes together
T8034 17390-17395 DT denotes these
T8035 17396-17403 NN denotes results
T8036 17404-17415 VB denotes demonstrate
T8037 17416-17420 IN denotes that
T8038 17421-17424 NN denotes A20
T8039 17425-17435 RB denotes negatively
T8040 17436-17445 VB denotes regulates
T8041 17446-17457 JJ denotes IAV-induced
T8042 17458-17473 JJ denotes proinflammatory
T8043 17474-17477 CC denotes and
T8044 17478-17487 JJ denotes antiviral
T8045 17488-17492 NN denotes gene
T8046 17493-17503 NN denotes expression
T8047 17504-17506 IN denotes in
T8048 17507-17515 JJ denotes alveolar
T8049 17516-17527 NN denotes macrophages
T8050 17527-17528 -COMMA- denotes ,
T8051 17529-17539 JJ denotes consistent
T8052 17540-17544 IN denotes with
T8053 17545-17548 DT denotes the
T8054 17549-17559 JJ denotes inhibitory
T8055 17560-17566 NN denotes effect
T8056 17567-17569 IN denotes of
T8057 17570-17573 NN denotes A20
T8058 17574-17578 VB denotes seen
T8059 17579-17581 IN denotes on
T8060 17582-17595 JJ denotes RIG-I-induced
T8061 17596-17601 NN denotes NF-κB
T8062 17602-17605 CC denotes and
T8063 17606-17610 NN denotes IRF3
T8064 17611-17621 NN denotes activation
T8926 17624-17627 NN denotes A20
T8927 17628-17638 NN denotes deficiency
T8928 17639-17641 IN denotes in
T8929 17642-17649 JJ denotes myeloid
T8930 17650-17655 NN denotes cells
T8931 17656-17664 VB denotes protects
T8932 17665-17672 IN denotes against
T8933 17673-17676 NN denotes IAV
T8934 17677-17681 NN denotes lung
T8935 17682-17691 NN denotes infection
T8936 17692-17694 TO denotes To
T8937 17695-17704 VB denotes determine
T8938 17705-17708 DT denotes the
T8939 17709-17713 NN denotes role
T8940 17714-17716 IN denotes of
T8941 17717-17720 NN denotes A20
T8942 17721-17731 NN denotes expression
T8943 17732-17734 IN denotes in
T8944 17735-17742 JJ denotes myeloid
T8945 17743-17748 NN denotes cells
T8946 17749-17755 IN denotes during
T8947 17756-17758 DT denotes an
T8948 17759-17762 NN denotes IAV
T8949 17763-17772 NN denotes infection
T8950 17773-17775 FW denotes in
T8951 17776-17780 FW denotes vivo
T8952 17780-17781 -COMMA- denotes ,
T8953 17782-17784 PRP denotes we
T8954 17785-17797 RB denotes intranasally
T8955 17798-17808 VB denotes inoculated
T8956 17809-17813 CC denotes both
T8957 17814-17824 NN denotes A20myel-KO
T8958 17825-17829 NN denotes mice
T8959 17830-17833 CC denotes and
T8960 17834-17841 NN denotes control
T8961 17842-17853 NN denotes littermates
T8962 17854-17858 IN denotes with
T8963 17859-17860 DT denotes a
T8964 17861-17870 JJ denotes sublethal
T8965 17871-17875 NN denotes dose
T8966 17876-17878 IN denotes of
T8967 17879-17882 DT denotes the
T8968 17883-17888 NN denotes mouse
T8969 17889-17896 VB denotes adapted
T8970 17897-17900 NN denotes IAV
T8971 17901-17905 NN denotes X-47
T8972 17906-17907 -LRB- denotes (
T8973 17907-17911 NN denotes H3N2
T8974 17911-17912 -RRB- denotes )
T8975 17913-17919 NN denotes strain
T8976 17920-17923 CC denotes and
T8977 17924-17933 VB denotes monitored
T8978 17934-17943 NN denotes morbidity
T8979 17944-17946 IN denotes in
T8980 17947-17952 NN denotes terms
T8981 17953-17955 IN denotes of
T8982 17956-17962 NN denotes weight
T8983 17963-17967 NN denotes loss
T8984 17969-17979 NN denotes A20myel-KO
T8985 17980-17984 NN denotes mice
T8986 17985-17991 VB denotes showed
T8987 17992-17999 VB denotes reduced
T8988 18000-18006 NN denotes weight
T8989 18007-18011 NN denotes loss
T8990 18012-18020 VB denotes compared
T8991 18021-18023 TO denotes to
T8992 18024-18028 JJ denotes wild
T8993 18029-18033 NN denotes type
T8994 18034-18041 NN denotes control
T8995 18042-18053 NN denotes littermates
T8996 18054-18057 CC denotes and
T8997 18058-18067 VB denotes recovered
T8998 18068-18074 RB denotes faster
T8999 18075-18079 IN denotes from
T9000 18080-18083 DT denotes the
T9001 18084-18089 JJ denotes viral
T9002 18090-18099 NN denotes challenge
T9003 18100-18101 -LRB- denotes (
T9004 18101-18107 NN denotes figure
T9005 18108-18110 NN denotes 3A
T9006 18110-18111 -RRB- denotes )
T9007 18113-18117 RB denotes Also
T9008 18117-18118 -COMMA- denotes ,
T9009 18119-18124 JJ denotes total
T9010 18125-18132 NN denotes protein
T9011 18133-18146 NN denotes concentration
T9012 18147-18149 IN denotes in
T9013 18150-18153 NN denotes BAL
T9014 18154-18159 NN denotes fluid
T9015 18159-18160 -COMMA- denotes ,
T9016 18161-18166 WDT denotes which
T9017 18167-18175 VB denotes reflects
T9018 18176-18180 NN denotes lung
T9019 18181-18187 NN denotes damage
T9020 18188-18191 CC denotes and
T9021 18192-18200 JJ denotes vascular
T9022 18201-18208 NN denotes leakage
T9023 18208-18209 -COMMA- denotes ,
T9024 18210-18213 VB denotes was
T9025 18214-18223 VB denotes increased
T9026 18224-18237 RB denotes significantly
T9027 18238-18240 IN denotes at
T9028 18241-18242 CD denotes 7
T9029 18243-18246 CC denotes and
T9030 18247-18249 CD denotes 10
T9031 18250-18254 NN denotes days
T9032 18255-18259 VB denotes post
T9033 18260-18269 NN denotes infection
T9034 18270-18272 IN denotes in
T9035 18273-18277 CC denotes both
T9036 18278-18282 JJ denotes wild
T9037 18283-18287 NN denotes type
T9038 18288-18291 CC denotes and
T9039 18292-18302 NN denotes A20myel-KO
T9040 18303-18307 NN denotes mice
T9041 18307-18308 -COMMA- denotes ,
T9042 18309-18312 CC denotes and
T9043 18313-18316 VB denotes was
T9044 18317-18325 RB denotes slightly
T9045 18326-18331 JJ denotes lower
T9046 18332-18334 IN denotes in
T9047 18335-18345 NN denotes A20myel-KO
T9048 18346-18350 NN denotes mice
T9049 18351-18352 -LRB- denotes (
T9050 18352-18356 NN denotes data
T9051 18357-18360 RB denotes not
T9052 18361-18366 VB denotes shown
T9053 18366-18367 -RRB- denotes )
T9054 18369-18373 RB denotes Next
T9055 18373-18374 -COMMA- denotes ,
T9056 18375-18377 PRP denotes we
T9057 18378-18386 VB denotes measured
T9058 18387-18396 JJ denotes pulmonary
T9059 18397-18402 JJ denotes viral
T9060 18403-18409 NN denotes titers
T9061 18410-18412 IN denotes at
T9062 18413-18414 CD denotes 4
T9063 18414-18415 -COMMA- denotes ,
T9064 18416-18417 CD denotes 7
T9065 18418-18421 CC denotes and
T9066 18422-18424 CD denotes 10
T9067 18425-18429 NN denotes days
T9068 18430-18434 JJ denotes post
T9069 18435-18444 NN denotes infection
T9070 18446-18448 DT denotes No
T9071 18449-18460 NN denotes differences
T9072 18461-18463 IN denotes in
T9073 18464-18469 JJ denotes viral
T9074 18470-18476 NN denotes titers
T9075 18477-18481 VB denotes were
T9076 18482-18490 VB denotes observed
T9077 18491-18493 IN denotes in
T9078 18494-18504 NN denotes A20myel-KO
T9079 18505-18509 NN denotes mice
T9080 18510-18516 IN denotes versus
T9081 18517-18521 JJ denotes wild
T9082 18522-18526 NN denotes type
T9083 18527-18531 NN denotes mice
T9084 18532-18534 IN denotes at
T9085 18535-18538 NN denotes day
T9086 18539-18540 CD denotes 4
T9087 18541-18544 CC denotes and
T9088 18545-18546 CD denotes 7
T9089 18547-18551 NN denotes post
T9090 18552-18561 NN denotes infection
T9091 18563-18570 RB denotes However
T9092 18570-18571 -COMMA- denotes ,
T9093 18572-18577 IN denotes after
T9094 18578-18580 CD denotes 10
T9095 18581-18585 NN denotes days
T9096 18585-18586 -COMMA- denotes ,
T9097 18587-18593 RB denotes almost
T9098 18594-18596 DT denotes no
T9099 18597-18602 NN denotes virus
T9100 18603-18608 MD denotes could
T9101 18609-18611 VB denotes be
T9102 18612-18620 VB denotes detected
T9103 18621-18623 IN denotes in
T9104 18624-18627 DT denotes the
T9105 18628-18633 NN denotes lungs
T9106 18634-18636 IN denotes of
T9107 18637-18647 NN denotes A20myel-KO
T9108 18648-18652 NN denotes mice
T9109 18653-18658 IN denotes while
T9110 18659-18667 JJ denotes abundant
T9111 18668-18678 JJ denotes infectious
T9112 18679-18684 JJ denotes viral
T9113 18685-18694 NN denotes particles
T9114 18695-18700 MD denotes could
T9115 18701-18706 RB denotes still
T9116 18707-18709 VB denotes be
T9117 18710-18718 VB denotes isolated
T9118 18719-18723 IN denotes from
T9119 18724-18729 NN denotes lungs
T9120 18730-18732 IN denotes of
T9121 18733-18736 DT denotes all
T9122 18737-18741 JJ denotes wild
T9123 18742-18746 NN denotes type
T9124 18747-18751 NN denotes mice
T9125 18752-18753 -LRB- denotes (
T9126 18753-18759 NN denotes figure
T9127 18760-18762 NN denotes 3B
T9128 18762-18763 -RRB- denotes )
T9129 18765-18769 DT denotes This
T9130 18770-18779 VB denotes indicates
T9131 18780-18784 IN denotes that
T9132 18785-18789 NN denotes loss
T9133 18790-18792 IN denotes of
T9134 18793-18796 NN denotes A20
T9135 18797-18799 IN denotes in
T9136 18800-18807 JJ denotes myeloid
T9137 18808-18813 NN denotes cells
T9138 18814-18818 VB denotes does
T9139 18819-18822 RB denotes not
T9140 18823-18829 VB denotes affect
T9141 18830-18835 JJ denotes early
T9142 18836-18841 JJ denotes viral
T9143 18842-18853 NN denotes replication
T9144 18854-18857 CC denotes but
T9145 18858-18869 VB denotes contributes
T9146 18870-18872 TO denotes to
T9147 18873-18878 JJ denotes viral
T9148 18879-18888 NN denotes clearance
T9149 18889-18891 IN denotes at
T9150 18892-18897 JJ denotes later
T9151 18898-18904 NN denotes stages
T9152 18905-18911 IN denotes during
T9153 18912-18921 NN denotes infection
T20805 18967-18970 NN denotes A20
T20806 18971-18981 NN denotes deficiency
T20807 18982-18984 IN denotes in
T20808 18985-18992 JJ denotes myeloid
T20809 18993-18998 NN denotes cells
T20810 18999-19007 VB denotes protects
T20811 19008-19015 IN denotes against
T20812 19016-19019 NN denotes IAV
T20813 19020-19024 NN denotes lung
T20814 19025-19034 NN denotes infection
T20815 19036-19046 NN denotes A20myel-WT
T20816 19047-19050 CC denotes and
T20817 19051-19061 NN denotes A20myel-KO
T20818 19062-19066 NN denotes mice
T20819 19067-19071 VB denotes were
T20820 19072-19080 VB denotes infected
T20821 19081-19093 RB denotes intranasally
T20822 19094-19098 IN denotes with
T20823 19099-19100 DT denotes a
T20824 19101-19110 JJ denotes sublethal
T20825 19111-19115 NN denotes dose
T20826 19116-19118 IN denotes of
T20827 19119-19122 NN denotes IAV
T20828 19123-19126 CC denotes and
T20829 19127-19133 NN denotes weight
T20830 19134-19138 NN denotes loss
T20831 19139-19142 VB denotes was
T20832 19143-19152 VB denotes monitored
T20833 19153-19154 -LRB- denotes (
T20834 19154-19155 NN denotes A
T20835 19155-19156 -RRB- denotes )
T20836 19158-19160 IN denotes At
T20837 19161-19164 NN denotes day
T20838 19165-19166 CD denotes 4
T20839 19166-19167 -COMMA- denotes ,
T20840 19168-19169 CD denotes 7
T20841 19170-19173 CC denotes and
T20842 19174-19176 CD denotes 10
T20843 19177-19181 NN denotes post
T20844 19182-19191 NN denotes infection
T20845 19192-19193 -LRB- denotes (
T20846 19193-19197 NN denotes p.i.
T20847 19197-19198 -RRB- denotes )
T20848 19199-19204 JJ denotes viral
T20849 19205-19211 NN denotes titers
T20850 19212-19214 IN denotes in
T20851 19215-19218 DT denotes the
T20852 19219-19223 NN denotes lung
T20853 19224-19228 VB denotes were
T20854 19229-19237 VB denotes measured
T20855 19238-19241 CC denotes and
T20856 19242-19251 VB denotes expressed
T20857 19252-19254 IN denotes as
T20858 19255-19259 JJ denotes mean
T20859 19260-19266 NN denotes TCID50
T20860 19267-19268 -LRB- denotes (
T20861 19268-19269 NN denotes B
T20862 19269-19270 -RRB- denotes )
T20863 19272-19275 DT denotes The
T20864 19276-19282 JJ denotes dashed
T20865 19283-19287 NN denotes line
T20866 19288-19298 VB denotes represents
T20867 19299-19302 DT denotes the
T20868 19303-19312 NN denotes detection
T20869 19313-19318 NN denotes limit
T20870 19320-19322 NN denotes ND
T20871 19322-19323 -COMMA- denotes ,
T20872 19324-19327 RB denotes not
T20873 19328-19338 JJ denotes detectable
T20874 19340-19343 NN denotes BAL
T20875 19344-19347 VB denotes was
T20876 19348-19356 VB denotes isolated
T20877 19357-19361 IN denotes from
T20878 19362-19365 NN denotes IAV
T20879 19366-19374 JJ denotes infected
T20880 19375-19379 NN denotes mice
T20881 19380-19382 IN denotes at
T20882 19383-19384 CD denotes 4
T20883 19384-19385 -COMMA- denotes ,
T20884 19386-19387 CD denotes 7
T20885 19388-19391 CC denotes and
T20886 19392-19394 CD denotes 10
T20887 19395-19399 NN denotes days
T20888 19400-19404 NN denotes p.i.
T20889 19405-19408 CC denotes and
T20890 19409-19411 NN denotes KC
T20891 19411-19412 -COMMA- denotes ,
T20892 19413-19418 NN denotes MIP-2
T20893 19418-19419 -COMMA- denotes ,
T20894 19420-19425 NN denotes MCP-1
T20895 19425-19426 -COMMA- denotes ,
T20896 19427-19431 NN denotes IL-6
T20897 19432-19435 CC denotes and
T20898 19436-19440 NN denotes IFNα
T20899 19441-19448 NN denotes protein
T20900 19449-19455 NN denotes levels
T20901 19456-19460 VB denotes were
T20902 19461-19469 VB denotes analyzed
T20903 19470-19472 IN denotes by
T20904 19473-19478 NN denotes ELISA
T20905 19479-19482 CC denotes and
T20906 19483-19495 JJ denotes multiplexing
T20907 19496-19508 NN denotes technologies
T20908 19509-19510 -LRB- denotes (
T20909 19510-19511 NN denotes C
T20910 19511-19512 -RRB- denotes )
T20911 19514-19522 JJ denotes Absolute
T20912 19523-19530 NN denotes numbers
T20913 19531-19533 IN denotes of
T20914 19534-19542 JJ denotes resident
T20915 19543-19551 JJ denotes alveolar
T20916 19552-19563 NN denotes macrophages
T20917 19563-19564 -COMMA- denotes ,
T20918 19565-19576 NN denotes neutrophils
T20919 19577-19580 CC denotes and
T20920 19581-19590 NN denotes monocytes
T20921 19591-19593 IN denotes in
T20922 19594-19597 NN denotes BAL
T20923 19598-19602 VB denotes were
T20924 19603-19611 VB denotes analyzed
T20925 19612-19614 IN denotes by
T20926 19615-19619 NN denotes flow
T20927 19620-19629 NN denotes cytometry
T20928 19630-19632 IN denotes at
T20929 19633-19634 CD denotes 4
T20930 19634-19635 -COMMA- denotes ,
T20931 19636-19637 CD denotes 7
T20932 19638-19641 CC denotes and
T20933 19642-19644 CD denotes 10
T20934 19645-19649 NN denotes days
T20935 19650-19654 NN denotes p.i.
T20936 19655-19656 -LRB- denotes (
T20937 19656-19657 NN denotes D
T20938 19657-19658 -RRB- denotes )
T20939 19660-19667 NN denotes Numbers
T20940 19668-19671 VB denotes are
T20941 19672-19680 NN denotes averages
T20942 19681-19684 CC denotes +/−
T20943 19685-19688 NN denotes SEM
T20944 19689-19691 IN denotes of
T20945 19692-19694 IN denotes at
T20946 19695-19700 JJ denotes least
T20947 19701-19702 CD denotes 5
T20948 19703-19707 NN denotes mice
T20949 19708-19711 IN denotes per
T20950 19712-19717 NN denotes group
T20951 19718-19721 CC denotes and
T20952 19722-19725 VB denotes are
T20953 19726-19740 JJ denotes representative
T20954 19741-19743 IN denotes of
T20955 19744-19745 CD denotes 2
T20956 19746-19757 JJ denotes independent
T20957 19758-19770 NN denotes experiments.
T20958 19771-19773 NN denotes *p
T20959 19773-19774 SYM denotes <
T20960 19774-19778 CD denotes 0.05
T20961 19778-19779 -COLON- denotes ;
T20962 19780-19783 NN denotes **p
T20963 19783-19784 SYM denotes <
T20964 19784-19788 CD denotes 0.01
T9154 19790-19792 TO denotes To
T9155 19793-19799 VB denotes verify
T9156 19800-19802 IN denotes if
T9157 19803-19806 NN denotes A20
T9158 19807-19817 NN denotes deficiency
T9159 19818-19820 IN denotes in
T9160 19821-19828 JJ denotes myeloid
T9161 19829-19834 NN denotes cells
T9162 19835-19842 VB denotes affects
T9163 19843-19854 JJ denotes IAV-induced
T9164 19855-19859 NN denotes gene
T9165 19860-19870 NN denotes expression
T9166 19871-19873 IN denotes in
T9167 19874-19877 DT denotes the
T9168 19878-19882 NN denotes lung
T9169 19882-19883 -COMMA- denotes ,
T9170 19884-19886 PRP denotes we
T9171 19887-19895 VB denotes analyzed
T9172 19896-19899 DT denotes the
T9173 19900-19906 NN denotes levels
T9174 19907-19909 IN denotes of
T9175 19910-19917 JJ denotes several
T9176 19918-19928 NN denotes chemokines
T9177 19929-19932 CC denotes and
T9178 19933-19942 NN denotes cytokines
T9179 19943-19945 IN denotes in
T9180 19946-19949 DT denotes the
T9181 19950-19965 JJ denotes bronchoalveolar
T9182 19966-19972 NN denotes lavage
T9183 19973-19974 -LRB- denotes (
T9184 19974-19977 NN denotes BAL
T9185 19977-19978 -RRB- denotes )
T9186 19979-19981 IN denotes at
T9187 19982-19985 NN denotes day
T9188 19986-19987 CD denotes 4
T9189 19987-19988 -COMMA- denotes ,
T9190 19989-19990 CD denotes 7
T9191 19991-19994 CC denotes and
T9192 19995-19998 NN denotes day
T9193 19999-20001 CD denotes 10
T9194 20002-20011 VB denotes following
T9195 20012-20021 NN denotes infection
T9196 20023-20029 NN denotes Levels
T9197 20030-20032 IN denotes of
T9198 20033-20035 NN denotes KC
T9199 20036-20039 CC denotes and
T9200 20040-20045 NN denotes MIP-2
T9201 20046-20056 NN denotes chemokines
T9202 20056-20057 -COMMA- denotes ,
T9203 20058-20060 RB denotes as
T9204 20061-20065 RB denotes well
T9205 20066-20068 IN denotes as
T9206 20069-20073 NN denotes IL-6
T9207 20074-20078 VB denotes were
T9208 20079-20092 RB denotes significantly
T9209 20093-20099 JJ denotes higher
T9210 20100-20102 IN denotes at
T9211 20103-20106 NN denotes day
T9212 20107-20108 CD denotes 7
T9213 20109-20113 NN denotes p.i.
T9214 20114-20116 IN denotes in
T9215 20117-20120 NN denotes BAL
T9216 20121-20125 IN denotes from
T9217 20126-20129 NN denotes IAV
T9218 20130-20138 JJ denotes infected
T9219 20139-20149 NN denotes A20myel-KO
T9220 20150-20154 NN denotes mice
T9221 20155-20163 VB denotes compared
T9222 20164-20166 TO denotes to
T9223 20167-20170 NN denotes IAV
T9224 20171-20179 JJ denotes infected
T9225 20180-20184 JJ denotes wild
T9226 20185-20189 NN denotes type
T9227 20190-20194 NN denotes mice
T9228 20195-20196 -LRB- denotes (
T9229 20196-20202 NN denotes figure
T9230 20203-20205 NN denotes 3C
T9231 20205-20206 -RRB- denotes )
T9232 20208-20214 IN denotes Unlike
T9233 20215-20218 PRP-DOLLAR- denotes our
T9234 20219-20231 NN denotes observations
T9235 20232-20236 IN denotes with
T9236 20237-20239 FW denotes in
T9237 20240-20245 FW denotes vitro
T9238 20246-20256 VB denotes stimulated
T9239 20257-20264 JJ denotes primary
T9240 20265-20276 NN denotes macrophages
T9241 20277-20279 PRP denotes we
T9242 20280-20285 MD denotes could
T9243 20286-20289 RB denotes not
T9244 20290-20296 VB denotes detect
T9245 20297-20298 DT denotes a
T9246 20299-20310 JJ denotes significant
T9247 20311-20319 NN denotes increase
T9248 20320-20322 IN denotes in
T9249 20323-20328 NN denotes MCP-1
T9250 20329-20331 CC denotes or
T9251 20332-20336 NN denotes IFNα
T9252 20337-20347 NN denotes production
T9253 20348-20350 IN denotes in
T9254 20351-20354 DT denotes the
T9255 20355-20360 NN denotes lungs
T9256 20361-20363 IN denotes of
T9257 20364-20374 NN denotes A20myel-KO
T9258 20375-20382 NN denotes animals
T9259 20383-20384 -LRB- denotes (
T9260 20384-20390 NN denotes figure
T9261 20391-20393 NN denotes 3C
T9262 20393-20394 -RRB- denotes )
T9263 20396-20398 NN denotes KC
T9264 20399-20401 VB denotes is
T9265 20402-20405 DT denotes the
T9266 20406-20412 JJ denotes murine
T9267 20413-20423 NN denotes orthologue
T9268 20424-20426 IN denotes of
T9269 20427-20431 NN denotes IL-8
T9270 20432-20435 CC denotes and
T9271 20436-20442 VB denotes serves
T9272 20443-20451 RB denotes together
T9273 20452-20456 IN denotes with
T9274 20457-20462 NN denotes MIP-2
T9275 20463-20465 IN denotes as
T9276 20466-20467 DT denotes a
T9277 20468-20483 NN denotes chemoattractant
T9278 20484-20487 IN denotes for
T9279 20488-20499 NN denotes neutrophils
T9280 20499-20500 -COMMA- denotes ,
T9281 20501-20506 IN denotes while
T9282 20507-20512 NN denotes MCP-1
T9283 20513-20515 VB denotes is
T9284 20516-20522 RB denotes mainly
T9285 20523-20528 VB denotes known
T9286 20529-20531 IN denotes as
T9287 20532-20533 DT denotes a
T9288 20534-20549 NN denotes chemoattractant
T9289 20550-20553 IN denotes for
T9290 20554-20563 NN denotes monocytes
T9291 20563-20564 -COMMA- denotes ,
T9292 20565-20570 WDT denotes which
T9293 20571-20581 RB denotes eventually
T9294 20582-20589 VB denotes develop
T9295 20590-20594 IN denotes into
T9296 20595-20606 NN denotes macrophages
T9297 20607-20611 IN denotes upon
T9298 20612-20620 VB denotes entering
T9299 20621-20624 DT denotes the
T9300 20625-20633 JJ denotes alveolar
T9301 20634-20639 NN denotes lumen
T9302 20640-20641 -LRB- denotes [
T9303 20641-20643 CD denotes 60
T9304 20643-20644 -RRB- denotes ]
T9305 20646-20656 JJ denotes Consistent
T9306 20657-20661 IN denotes with
T9307 20662-20665 DT denotes the
T9308 20666-20672 JJ denotes higher
T9309 20673-20675 NN denotes KC
T9310 20676-20679 CC denotes and
T9311 20680-20685 NN denotes MIP-2
T9312 20686-20692 NN denotes levels
T9313 20693-20695 IN denotes in
T9314 20696-20706 NN denotes A20myel-KO
T9315 20707-20711 NN denotes mice
T9316 20711-20712 -COMMA- denotes ,
T9317 20713-20716 DT denotes the
T9318 20717-20723 NN denotes number
T9319 20724-20726 IN denotes of
T9320 20727-20738 NN denotes neutrophils
T9321 20739-20740 -LRB- denotes (
T9322 20740-20746 JJ denotes CD11b+
T9323 20747-20752 JJ denotes Ly6C+
T9324 20753-20758 JJ denotes Ly6G+
T9325 20759-20765 NN denotes F4/80−
T9326 20765-20766 -RRB- denotes )
T9327 20767-20771 WDT denotes that
T9328 20772-20776 VB denotes were
T9329 20777-20786 VB denotes recruited
T9330 20787-20789 IN denotes in
T9331 20790-20793 DT denotes the
T9332 20794-20809 JJ denotes bronchoalveolar
T9333 20810-20816 NN denotes spaces
T9334 20817-20821 IN denotes upon
T9335 20822-20825 NN denotes IAV
T9336 20826-20835 NN denotes infection
T9337 20836-20839 VB denotes was
T9338 20840-20847 RB denotes clearly
T9339 20848-20854 JJ denotes higher
T9340 20855-20865 IN denotes throughout
T9341 20866-20875 NN denotes infection
T9342 20876-20878 IN denotes in
T9343 20879-20889 NN denotes A20myel-KO
T9344 20890-20894 NN denotes mice
T9345 20895-20903 VB denotes compared
T9346 20904-20906 TO denotes to
T9347 20907-20914 NN denotes control
T9348 20915-20922 NN denotes animals
T9349 20923-20924 -LRB- denotes (
T9350 20924-20930 NN denotes figure
T9351 20931-20933 NN denotes 3D
T9352 20933-20934 -RRB- denotes )
T9353 20936-20944 IN denotes Although
T9354 20945-20947 PRP denotes we
T9355 20948-20953 MD denotes could
T9356 20954-20960 VB denotes detect
T9357 20961-20962 DT denotes a
T9358 20963-20974 JJ denotes significant
T9359 20975-20983 NN denotes increase
T9360 20984-20986 IN denotes in
T9361 20987-20995 NN denotes monocyte
T9362 20996-20997 -LRB- denotes (
T9363 20997-21003 JJ denotes CD11b+
T9364 21004-21009 NN denotes Ly6C+
T9365 21009-21010 -RRB- denotes )
T9366 21011-21022 NN denotes recruitment
T9367 21023-21025 IN denotes at
T9368 21026-21029 NN denotes day
T9369 21030-21031 CD denotes 4
T9370 21032-21036 NN denotes post
T9371 21037-21046 NN denotes infection
T9372 21046-21047 -COMMA- denotes ,
T9373 21048-21052 DT denotes this
T9374 21053-21056 VB denotes was
T9375 21057-21060 RB denotes not
T9376 21061-21068 JJ denotes evident
T9377 21069-21071 IN denotes at
T9378 21072-21077 JJ denotes later
T9379 21078-21082 NN denotes time
T9380 21083-21089 NN denotes points
T9381 21090-21095 IN denotes after
T9382 21096-21105 NN denotes infection
T9383 21106-21107 -LRB- denotes (
T9384 21107-21113 NN denotes figure
T9385 21114-21116 NN denotes 3D
T9386 21116-21117 -RRB- denotes )
T9387 21117-21118 -COMMA- denotes ,
T9388 21119-21124 WDT denotes which
T9389 21125-21127 VB denotes is
T9390 21128-21138 JJ denotes consistent
T9391 21139-21143 IN denotes with
T9392 21144-21147 DT denotes the
T9393 21148-21153 JJ denotes equal
T9394 21154-21164 NN denotes expression
T9395 21165-21167 IN denotes of
T9396 21168-21173 NN denotes MCP-1
T9397 21174-21176 IN denotes in
T9398 21177-21181 DT denotes both
T9399 21182-21188 NN denotes groups
T9400 21189-21191 IN denotes of
T9401 21192-21196 NN denotes mice
T9402 21198-21201 DT denotes The
T9403 21202-21208 NN denotes number
T9404 21209-21211 IN denotes of
T9405 21212-21220 JJ denotes resident
T9406 21221-21229 JJ denotes alveolar
T9407 21230-21241 NN denotes macrophages
T9408 21242-21243 -LRB- denotes (
T9409 21243-21259 JJ denotes autofluorescent+
T9410 21260-21266 JJ denotes CD11c+
T9411 21267-21273 NN denotes F4/80+
T9412 21274-21280 NN denotes CD11b−
T9413 21280-21281 -RRB- denotes )
T9414 21282-21285 VB denotes was
T9415 21286-21290 RB denotes also
T9416 21291-21299 VB denotes elevated
T9417 21300-21302 IN denotes in
T9418 21303-21313 NN denotes A20myel-KO
T9419 21314-21318 NN denotes mice
T9420 21319-21322 CC denotes but
T9421 21323-21326 VB denotes did
T9422 21327-21330 RB denotes not
T9423 21331-21337 VB denotes differ
T9424 21338-21351 RB denotes significantly
T9425 21352-21359 IN denotes between
T9426 21360-21363 NN denotes IAV
T9427 21364-21372 JJ denotes infected
T9428 21373-21375 CC denotes or
T9429 21376-21380 JJ denotes mock
T9430 21381-21389 JJ denotes infected
T9431 21390-21394 NN denotes mice
T9432 21395-21396 -LRB- denotes (
T9433 21396-21402 NN denotes figure
T9434 21403-21405 NN denotes 3D
T9435 21405-21406 -RRB- denotes )
T9436 21408-21419 NN denotes Elimination
T9437 21420-21422 IN denotes of
T9438 21423-21426 NN denotes IAV
T9439 21427-21435 JJ denotes infected
T9440 21436-21441 NN denotes cells
T9441 21442-21449 VB denotes depends
T9442 21450-21452 IN denotes on
T9443 21453-21456 DT denotes the
T9444 21457-21463 JJ denotes clonal
T9445 21464-21473 NN denotes expansion
T9446 21474-21476 IN denotes of
T9447 21477-21482 NN denotes virus
T9448 21483-21491 JJ denotes specific
T9449 21492-21501 JJ denotes cytotoxic
T9450 21502-21506 JJ denotes CD8+
T9451 21507-21508 NN denotes T
T9452 21509-21514 NN denotes cells
T9453 21515-21516 -LRB- denotes (
T9454 21516-21519 NN denotes CTL
T9455 21519-21520 -RRB- denotes )
T9456 21521-21522 -LRB- denotes [
T9457 21522-21524 CD denotes 61
T9458 21524-21525 -RRB- denotes ]
T9459 21525-21526 -COMMA- denotes ,
T9460 21527-21528 -LRB- denotes [
T9461 21528-21530 CD denotes 62
T9462 21530-21531 -RRB- denotes ]
T9463 21531-21532 -COMMA- denotes ,
T9464 21533-21534 -LRB- denotes [
T9465 21534-21536 CD denotes 63
T9466 21536-21537 -RRB- denotes ]
T9467 21539-21541 TO denotes To
T9468 21542-21546 VB denotes test
T9469 21547-21554 IN denotes whether
T9470 21555-21558 NN denotes A20
T9471 21559-21569 NN denotes expression
T9472 21570-21572 IN denotes in
T9473 21573-21580 JJ denotes myeloid
T9474 21581-21586 NN denotes cells
T9475 21587-21596 VB denotes regulates
T9476 21597-21600 DT denotes the
T9477 21601-21610 JJ denotes antiviral
T9478 21611-21614 NN denotes CTL
T9479 21615-21623 NN denotes response
T9480 21623-21624 -COMMA- denotes ,
T9481 21625-21630 JJ denotes total
T9482 21631-21635 JJ denotes CD8+
T9483 21636-21637 NN denotes T
T9484 21638-21643 NN denotes cells
T9485 21644-21647 CC denotes and
T9486 21648-21653 NN denotes virus
T9487 21654-21662 JJ denotes specific
T9488 21663-21671 NN denotes Granzyme
T9489 21672-21673 NN denotes B
T9490 21674-21675 -LRB- denotes (
T9491 21675-21678 NN denotes GrB
T9492 21678-21679 -RRB- denotes )
T9493 21680-21683 CC denotes and
T9494 21684-21688 NN denotes IFNγ
T9495 21689-21699 VB denotes expressing
T9496 21700-21704 JJ denotes CD8+
T9497 21705-21706 NN denotes T
T9498 21707-21712 NN denotes cells
T9499 21713-21717 VB denotes were
T9500 21718-21726 VB denotes measured
T9501 21727-21729 IN denotes in
T9502 21730-21733 NN denotes BAL
T9503 21734-21737 CC denotes and
T9504 21738-21742 NN denotes lung
T9505 21743-21753 NN denotes parenchyma
T9506 21754-21756 IN denotes of
T9507 21757-21761 JJ denotes wild
T9508 21762-21766 NN denotes type
T9509 21767-21770 CC denotes and
T9510 21771-21781 NN denotes A20myel-KO
T9511 21782-21786 NN denotes mice
T9512 21788-21789 DT denotes A
T9513 21790-21795 JJ denotes clear
T9514 21796-21804 NN denotes increase
T9515 21805-21807 IN denotes in
T9516 21808-21812 JJ denotes CD8+
T9517 21813-21814 NN denotes T
T9518 21815-21820 NN denotes cells
T9519 21821-21826 MD denotes could
T9520 21827-21829 VB denotes be
T9521 21830-21838 VB denotes detected
T9522 21839-21841 IN denotes at
T9523 21842-21845 NN denotes day
T9524 21846-21847 CD denotes 7
T9525 21848-21851 CC denotes and
T9526 21852-21854 CD denotes 10
T9527 21855-21859 NN denotes post
T9528 21860-21869 NN denotes infection
T9529 21869-21870 -COMMA- denotes ,
T9530 21871-21874 CC denotes but
T9531 21875-21877 DT denotes no
T9532 21878-21889 NN denotes differences
T9533 21890-21894 VB denotes were
T9534 21895-21903 VB denotes observed
T9535 21904-21911 IN denotes between
T9536 21912-21922 NN denotes A20myel-KO
T9537 21923-21926 CC denotes and
T9538 21927-21931 JJ denotes wild
T9539 21932-21936 NN denotes type
T9540 21937-21941 NN denotes mice
T9541 21942-21943 -LRB- denotes (
T9542 21943-21949 NN denotes figure
T9543 21950-21953 NN denotes S2A
T9544 21954-21957 CC denotes and
T9545 21958-21964 NN denotes figure
T9546 21965-21968 NN denotes S2C
T9547 21968-21969 -RRB- denotes )
T9548 21971-21975 RB denotes Also
T9549 21975-21976 -COMMA- denotes ,
T9550 21977-21980 DT denotes the
T9551 21981-21987 NN denotes number
T9552 21988-21990 IN denotes of
T9553 21991-21994 NN denotes GrB
T9554 21995-21998 CC denotes and
T9555 21999-22003 NN denotes IFNγ
T9556 22004-22008 JJ denotes CD8+
T9557 22009-22010 NN denotes T
T9558 22011-22016 NN denotes cells
T9559 22017-22019 RB denotes as
T9560 22020-22024 RB denotes well
T9561 22025-22027 IN denotes as
T9562 22028-22032 NN denotes IFNγ
T9563 22033-22043 NN denotes expression
T9564 22044-22050 NN denotes levels
T9565 22051-22053 IN denotes in
T9566 22054-22057 DT denotes the
T9567 22058-22063 NN denotes lungs
T9568 22064-22068 VB denotes were
T9569 22069-22072 RB denotes not
T9570 22073-22080 VB denotes altered
T9571 22081-22083 IN denotes by
T9572 22084-22087 DT denotes the
T9573 22088-22095 NN denotes absence
T9574 22096-22098 IN denotes of
T9575 22099-22102 NN denotes A20
T9576 22103-22105 IN denotes in
T9577 22106-22113 JJ denotes myeloid
T9578 22114-22119 NN denotes cells
T9579 22120-22121 -LRB- denotes (
T9580 22121-22127 NN denotes figure
T9581 22128-22133 NN denotes S2A–C
T9582 22133-22134 -RRB- denotes )
T9583 22136-22146 NN denotes Protection
T9584 22147-22154 IN denotes against
T9585 22155-22158 NN denotes IAV
T9586 22159-22168 NN denotes infection
T9587 22169-22171 VB denotes is
T9588 22172-22176 RB denotes also
T9589 22177-22185 VB denotes provided
T9590 22186-22188 IN denotes by
T9591 22189-22192 DT denotes the
T9592 22193-22200 JJ denotes humoral
T9593 22201-22207 JJ denotes immune
T9594 22208-22216 NN denotes response
T9595 22218-22220 TO denotes To
T9596 22221-22225 VB denotes test
T9597 22226-22233 IN denotes whether
T9598 22234-22238 NN denotes loss
T9599 22239-22241 IN denotes of
T9600 22242-22245 NN denotes A20
T9601 22246-22248 IN denotes in
T9602 22249-22256 JJ denotes myeloid
T9603 22257-22262 NN denotes cells
T9604 22263-22270 VB denotes affects
T9605 22271-22272 NN denotes B
T9606 22273-22277 NN denotes cell
T9607 22278-22286 VB denotes mediated
T9608 22287-22295 NN denotes immunity
T9609 22295-22296 -COMMA- denotes ,
T9610 22297-22299 PRP denotes we
T9611 22300-22310 VB denotes determined
T9612 22311-22324 NN denotes hemagglutinin
T9613 22325-22326 -LRB- denotes (
T9614 22326-22328 NN denotes HA
T9615 22328-22329 -RRB- denotes )
T9616 22330-22338 NN denotes antibody
T9617 22339-22345 NN denotes titers
T9618 22346-22348 IN denotes in
T9619 22349-22352 DT denotes the
T9620 22353-22358 NN denotes serum
T9621 22359-22361 IN denotes of
T9622 22362-22372 NN denotes A20myel-KO
T9623 22373-22376 CC denotes and
T9624 22377-22381 JJ denotes wild
T9625 22382-22386 NN denotes type
T9626 22387-22398 NN denotes littermates
T9627 22400-22407 RB denotes However
T9628 22407-22408 -COMMA- denotes ,
T9629 22409-22411 DT denotes no
T9630 22412-22423 NN denotes differences
T9631 22424-22429 MD denotes could
T9632 22430-22432 VB denotes be
T9633 22433-22441 VB denotes detected
T9634 22442-22449 IN denotes between
T9635 22450-22454 JJ denotes wild
T9636 22455-22459 NN denotes type
T9637 22460-22463 CC denotes and
T9638 22464-22474 NN denotes A20myel-KO
T9639 22475-22482 NN denotes animals
T9640 22483-22484 -LRB- denotes (
T9641 22484-22490 NN denotes figure
T9642 22491-22494 NN denotes S2D
T9643 22494-22495 -RRB- denotes )
T9644 22495-22496 -COMMA- denotes ,
T9645 22497-22507 VB denotes indicating
T9646 22508-22512 IN denotes that
T9647 22513-22520 JJ denotes humoral
T9648 22521-22529 NN denotes immunity
T9649 22530-22532 VB denotes is
T9650 22533-22536 RB denotes not
T9651 22537-22545 VB denotes affected
T9652 22546-22548 IN denotes by
T9653 22549-22552 NN denotes A20
T9654 22553-22563 NN denotes expression
T9655 22564-22566 IN denotes in
T9656 22567-22574 JJ denotes myeloid
T9657 22575-22580 NN denotes cells
T9658 22582-22590 RB denotes Together
T9659 22590-22591 -COMMA- denotes ,
T9660 22592-22597 DT denotes these
T9661 22598-22602 NN denotes data
T9662 22603-22610 VB denotes suggest
T9663 22611-22615 IN denotes that
T9664 22616-22626 NN denotes mechanisms
T9665 22627-22632 JJ denotes other
T9666 22633-22637 IN denotes than
T9667 22638-22646 JJ denotes adaptive
T9668 22647-22655 NN denotes immunity
T9669 22655-22656 -COMMA- denotes ,
T9670 22657-22661 JJ denotes such
T9671 22662-22664 IN denotes as
T9672 22665-22667 DT denotes an
T9673 22668-22677 VB denotes increased
T9674 22678-22684 JJ denotes innate
T9675 22685-22691 JJ denotes immune
T9676 22692-22700 NN denotes response
T9677 22700-22701 -COMMA- denotes ,
T9678 22702-22715 VB denotes characterized
T9679 22716-22718 IN denotes by
T9680 22719-22721 DT denotes an
T9681 22722-22731 VB denotes increased
T9682 22732-22738 NN denotes influx
T9683 22739-22741 IN denotes of
T9684 22742-22753 NN denotes neutrophils
T9685 22754-22757 CC denotes and
T9686 22758-22767 VB denotes increased
T9687 22768-22775 NN denotes numbers
T9688 22776-22778 IN denotes of
T9689 22779-22787 JJ denotes alveolar
T9690 22788-22799 NN denotes macrophages
T9691 22799-22800 -COMMA- denotes ,
T9692 22801-22811 VB denotes contribute
T9693 22812-22814 TO denotes to
T9694 22815-22818 DT denotes the
T9695 22819-22825 JJ denotes better
T9696 22826-22831 JJ denotes viral
T9697 22832-22841 NN denotes clearance
T9698 22842-22844 IN denotes in
T9699 22845-22855 NN denotes A20myel-KO
T9700 22856-22860 NN denotes mice
T9701 22862-22864 PRP denotes It
T9702 22865-22867 VB denotes is
T9703 22868-22877 RB denotes generally
T9704 22878-22886 VB denotes believed
T9705 22887-22891 IN denotes that
T9706 22892-22903 JJ denotes IAV-induced
T9707 22904-22913 NN denotes mortality
T9708 22914-22916 VB denotes is
T9709 22917-22920 IN denotes due
T9710 22921-22923 TO denotes to
T9711 22924-22926 DT denotes an
T9712 22927-22936 JJ denotes excessive
T9713 22937-22952 JJ denotes proinflammatory
T9714 22953-22961 NN denotes response
T9715 22962-22964 IN denotes in
T9716 22965-22968 DT denotes the
T9717 22969-22973 NN denotes lung
T9718 22975-22977 PRP denotes We
T9719 22978-22987 RB denotes therefore
T9720 22988-22996 VB denotes analyzed
T9721 22997-23004 IN denotes whether
T9722 23005-23008 DT denotes the
T9723 23009-23018 VB denotes increased
T9724 23019-23034 JJ denotes proinflammatory
T9725 23035-23043 NN denotes cytokine
T9726 23044-23054 NN denotes production
T9727 23055-23058 CC denotes and
T9728 23059-23071 NN denotes infiltration
T9729 23072-23074 IN denotes of
T9730 23075-23090 JJ denotes proinflammatory
T9731 23091-23096 NN denotes cells
T9732 23097-23099 IN denotes in
T9733 23100-23110 NN denotes A20myel-KO
T9734 23111-23115 NN denotes mice
T9735 23116-23123 VB denotes affects
T9736 23124-23133 NN denotes mortality
T9737 23134-23141 VB denotes induced
T9738 23142-23144 IN denotes by
T9739 23145-23155 JJ denotes intranasal
T9740 23156-23165 NN denotes infection
T9741 23166-23170 IN denotes with
T9742 23171-23172 DT denotes a
T9743 23173-23179 JJ denotes lethal
T9744 23180-23184 NN denotes dose
T9745 23185-23187 IN denotes of
T9746 23188-23191 NN denotes IAV
T9747 23192-23196 NN denotes X-47
T9748 23198-23210 RB denotes Surprisingly
T9749 23210-23211 -COMMA- denotes ,
T9750 23212-23218 RB denotes almost
T9751 23219-23222 DT denotes all
T9752 23223-23233 NN denotes A20myel-KO
T9753 23234-23238 NN denotes mice
T9754 23239-23247 VB denotes survived
T9755 23248-23249 -LRB- denotes (
T9756 23249-23254 CD denotes 10/11
T9757 23254-23255 -RRB- denotes )
T9758 23255-23256 -COMMA- denotes ,
T9759 23257-23262 IN denotes while
T9760 23263-23266 DT denotes all
T9761 23267-23274 NN denotes control
T9762 23275-23279 NN denotes mice
T9763 23280-23289 VB denotes succumbed
T9764 23290-23291 -LRB- denotes (
T9765 23291-23295 CD denotes 0/11
T9766 23295-23296 -RRB- denotes )
T9767 23297-23303 IN denotes within
T9768 23304-23306 CD denotes 16
T9769 23307-23311 NN denotes days
T9770 23312-23317 IN denotes after
T9771 23318-23327 NN denotes infection
T9772 23328-23329 -LRB- denotes (
T9773 23329-23335 NN denotes figure
T9774 23336-23338 NN denotes 4A
T9775 23338-23339 -RRB- denotes )
T9776 23341-23351 NN denotes A20myel-KO
T9777 23352-23356 NN denotes mice
T9778 23357-23362 RB denotes still
T9779 23363-23369 VB denotes showed
T9780 23370-23381 JJ denotes significant
T9781 23382-23388 NN denotes weight
T9782 23389-23393 NN denotes loss
T9783 23394-23397 CC denotes and
T9784 23398-23402 NN denotes lung
T9785 23403-23409 NN denotes damage
T9786 23410-23411 -LRB- denotes (
T9787 23411-23413 IN denotes as
T9788 23414-23423 VB denotes reflected
T9789 23424-23426 IN denotes by
T9790 23427-23436 VB denotes increased
T9791 23437-23442 JJ denotes total
T9792 23443-23450 NN denotes protein
T9793 23451-23464 NN denotes concentration
T9794 23465-23467 IN denotes in
T9795 23468-23471 DT denotes the
T9796 23472-23475 NN denotes BAL
T9797 23475-23476 -COLON- denotes ;
T9798 23477-23481 NN denotes data
T9799 23482-23485 RB denotes not
T9800 23486-23491 VB denotes shown
T9801 23491-23492 -RRB- denotes )
T9802 23493-23499 IN denotes during
T9803 23500-23503 DT denotes the
T9804 23504-23510 NN denotes course
T9805 23511-23513 IN denotes of
T9806 23514-23523 NN denotes infection
T9807 23524-23527 CC denotes but
T9808 23528-23532 VB denotes were
T9809 23533-23537 JJ denotes able
T9810 23538-23540 TO denotes to
T9811 23541-23548 VB denotes recover
T9812 23548-23549 -COMMA- denotes ,
T9813 23550-23552 IN denotes in
T9814 23553-23561 NN denotes contrast
T9815 23562-23564 TO denotes to
T9816 23565-23569 JJ denotes wild
T9817 23570-23574 NN denotes type
T9818 23575-23579 NN denotes mice
T9819 23580-23584 WDT denotes that
T9820 23585-23594 VB denotes succumbed
T9821 23595-23596 -LRB- denotes (
T9822 23596-23602 NN denotes figure
T9823 23603-23605 NN denotes 4B
T9824 23605-23606 -RRB- denotes )
T9825 23608-23615 JJ denotes Similar
T9826 23616-23618 TO denotes to
T9827 23619-23622 PRP-DOLLAR- denotes our
T9828 23623-23635 NN denotes observations
T9829 23636-23640 IN denotes with
T9830 23641-23650 JJ denotes sublethal
T9831 23651-23654 NN denotes IAV
T9832 23655-23664 NN denotes infection
T9833 23664-23665 -COMMA- denotes ,
T9834 23666-23675 JJ denotes pulmonary
T9835 23676-23678 NN denotes KC
T9836 23679-23682 CC denotes and
T9837 23683-23688 NN denotes MIP-2
T9838 23689-23699 NN denotes production
T9839 23700-23703 VB denotes was
T9840 23704-23712 JJ denotes stronger
T9841 23713-23715 IN denotes in
T9842 23716-23726 NN denotes A20myel-KO
T9843 23727-23734 NN denotes animals
T9844 23735-23743 VB denotes compared
T9845 23744-23746 TO denotes to
T9846 23747-23751 JJ denotes wild
T9847 23752-23756 NN denotes type
T9848 23757-23761 NN denotes mice
T9849 23762-23771 VB denotes following
T9850 23772-23778 JJ denotes lethal
T9851 23779-23782 NN denotes IAV
T9852 23783-23792 NN denotes infection
T9853 23793-23794 -LRB- denotes (
T9854 23794-23800 NN denotes figure
T9855 23801-23803 NN denotes 4C
T9856 23803-23804 -RRB- denotes )
T9857 23804-23805 -COMMA- denotes ,
T9858 23806-23811 WDT denotes which
T9859 23812-23822 VB denotes correlates
T9860 23823-23827 IN denotes with
T9861 23828-23831 DT denotes the
T9862 23832-23841 VB denotes increased
T9863 23842-23849 NN denotes numbers
T9864 23850-23852 IN denotes of
T9865 23853-23864 NN denotes neutrophils
T9866 23865-23867 IN denotes in
T9867 23868-23871 DT denotes the
T9868 23872-23877 NN denotes lungs
T9869 23878-23880 IN denotes of
T9870 23881-23886 DT denotes these
T9871 23887-23891 NN denotes mice
T9872 23892-23893 -LRB- denotes (
T9873 23893-23899 NN denotes figure
T9874 23900-23902 NN denotes 4C
T9875 23902-23903 -RRB- denotes )
T9876 23905-23909 RB denotes Also
T9877 23910-23916 NN denotes levels
T9878 23917-23919 IN denotes of
T9879 23920-23923 DT denotes the
T9880 23924-23939 JJ denotes proinflammatory
T9881 23940-23949 NN denotes cytokines
T9882 23950-23954 NN denotes IL-6
T9883 23954-23955 -COMMA- denotes ,
T9884 23956-23959 NN denotes TNF
T9885 23960-23963 CC denotes and
T9886 23964-23969 NN denotes IL-1β
T9887 23969-23970 -COMMA- denotes ,
T9888 23971-23976 WDT denotes which
T9889 23977-23980 VB denotes are
T9890 23981-23986 RB denotes often
T9891 23987-23997 VB denotes associated
T9892 23998-24002 IN denotes with
T9893 24003-24021 NN denotes immunopathogenesis
T9894 24022-24024 IN denotes in
T9895 24025-24031 NN denotes humans
T9896 24032-24033 -LRB- denotes [
T9897 24033-24035 CD denotes 64
T9898 24035-24036 -RRB- denotes ]
T9899 24036-24037 -COMMA- denotes ,
T9900 24038-24042 VB denotes were
T9901 24043-24052 VB denotes increased
T9902 24053-24055 IN denotes in
T9903 24056-24059 DT denotes the
T9904 24060-24065 NN denotes lungs
T9905 24066-24068 IN denotes of
T9906 24069-24079 NN denotes A20myel-KO
T9907 24080-24084 NN denotes mice
T9908 24085-24093 VB denotes compared
T9909 24094-24096 TO denotes to
T9910 24097-24104 NN denotes control
T9911 24105-24112 NN denotes animals
T9912 24113-24114 -LRB- denotes (
T9913 24114-24120 NN denotes figure
T9914 24121-24123 NN denotes 4C
T9915 24124-24127 CC denotes and
T9916 24128-24134 NN denotes figure
T9917 24135-24138 NN denotes S3A
T9918 24138-24139 -RRB- denotes )
T9919 24141-24146 RB denotes Again
T9920 24146-24147 -COMMA- denotes ,
T9921 24148-24153 NN denotes MCP-1
T9922 24154-24164 NN denotes production
T9923 24165-24168 VB denotes was
T9924 24169-24172 RB denotes not
T9925 24173-24182 VB denotes increased
T9926 24183-24186 CC denotes and
T9927 24187-24191 RB denotes even
T9928 24192-24197 JJ denotes lower
T9929 24198-24200 IN denotes in
T9930 24201-24211 NN denotes A20myel-KO
T9931 24212-24216 NN denotes mice
T9932 24217-24218 -LRB- denotes (
T9933 24218-24224 NN denotes figure
T9934 24225-24227 NN denotes 4C
T9935 24227-24228 -RRB- denotes )
T9936 24228-24229 -COMMA- denotes ,
T9937 24230-24233 CC denotes and
T9938 24234-24238 RB denotes also
T9939 24239-24247 NN denotes monocyte
T9940 24248-24259 NN denotes recruitment
T9941 24260-24263 VB denotes was
T9942 24264-24267 RB denotes not
T9943 24268-24277 JJ denotes different
T9944 24278-24285 IN denotes between
T9945 24286-24290 DT denotes both
T9946 24291-24297 NN denotes groups
T9947 24298-24300 IN denotes of
T9948 24301-24305 NN denotes mice
T9949 24307-24309 PRP denotes We
T9950 24310-24315 MD denotes could
T9951 24316-24320 RB denotes also
T9952 24321-24324 RB denotes not
T9953 24325-24331 VB denotes detect
T9954 24332-24335 DT denotes any
T9955 24336-24347 NN denotes differences
T9956 24348-24350 IN denotes in
T9957 24351-24356 JJ denotes viral
T9958 24357-24366 NN denotes clearance
T9959 24367-24369 CC denotes or
T9960 24370-24379 JJ denotes antiviral
T9961 24380-24388 JJ denotes adaptive
T9962 24389-24397 NN denotes immunity
T9963 24398-24400 IN denotes at
T9964 24401-24402 CD denotes 6
T9965 24403-24404 NN denotes h
T9966 24405-24409 NN denotes post
T9967 24410-24419 NN denotes infection
T9968 24420-24421 -LRB- denotes (
T9969 24421-24427 NN denotes figure
T9970 24428-24433 NN denotes S3B–F
T9971 24433-24434 -RRB- denotes )
T9972 24436-24448 RB denotes Collectively
T9973 24449-24454 DT denotes these
T9974 24455-24459 NN denotes data
T9975 24460-24468 VB denotes indicate
T9976 24469-24473 IN denotes that
T9977 24474-24477 NN denotes A20
T9978 24478-24488 NN denotes deficiency
T9979 24489-24491 IN denotes in
T9980 24492-24499 JJ denotes myeloid
T9981 24500-24505 NN denotes cells
T9982 24506-24508 VB denotes is
T9983 24509-24519 VB denotes associated
T9984 24520-24524 IN denotes with
T9985 24525-24527 DT denotes an
T9986 24528-24537 VB denotes increased
T9987 24538-24544 JJ denotes innate
T9988 24545-24551 JJ denotes immune
T9989 24552-24560 NN denotes response
T9990 24561-24564 CC denotes and
T9991 24565-24575 NN denotes protection
T9992 24576-24583 IN denotes against
T9993 24584-24585 DT denotes a
T9994 24586-24592 JJ denotes lethal
T9995 24593-24596 NN denotes IAV
T9996 24597-24606 NN denotes infection
T21246 24652-24655 NN denotes A20
T21247 24656-24666 NN denotes deficiency
T21248 24667-24669 IN denotes in
T21249 24670-24677 JJ denotes myeloid
T21250 24678-24683 NN denotes cells
T21251 24684-24692 VB denotes protects
T21252 24693-24700 IN denotes against
T21253 24701-24707 JJ denotes lethal
T21254 24708-24711 NN denotes IAV
T21255 24712-24721 NN denotes infection
T21256 24723-24733 NN denotes A20myel-WT
T21257 24734-24735 -LRB- denotes (
T21258 24735-24741 NN denotes n = 11
T21259 24741-24742 -RRB- denotes )
T21260 24743-24746 CC denotes and
T21261 24747-24757 NN denotes A20myel-KO
T21262 24758-24759 -LRB- denotes (
T21263 24759-24765 NN denotes n = 11
T21264 24765-24766 -RRB- denotes )
T21265 24767-24771 NN denotes mice
T21266 24772-24776 VB denotes were
T21267 24777-24789 RB denotes intranasally
T21268 24790-24798 VB denotes infected
T21269 24799-24803 IN denotes with
T21270 24804-24805 DT denotes a
T21271 24806-24812 JJ denotes lethal
T21272 24813-24817 NN denotes dose
T21273 24818-24820 IN denotes of
T21274 24821-24824 NN denotes IAV
T21275 24825-24828 CC denotes and
T21276 24829-24837 NN denotes survival
T21277 24838-24839 -LRB- denotes (
T21278 24839-24840 NN denotes p
T21279 24840-24841 SYM denotes <
T21280 24841-24846 CD denotes 0.001
T21281 24846-24847 -RRB- denotes )
T21282 24848-24849 -LRB- denotes (
T21283 24849-24850 NN denotes A
T21284 24850-24851 -RRB- denotes )
T21285 24852-24855 CC denotes and
T21286 24856-24862 NN denotes weight
T21287 24863-24867 NN denotes loss
T21288 24868-24871 CC denotes +/−
T21289 24872-24875 NN denotes SEM
T21290 24876-24877 -LRB- denotes (
T21291 24877-24878 NN denotes B
T21292 24878-24879 -RRB- denotes )
T21293 24880-24883 VB denotes was
T21294 24884-24893 VB denotes monitored
T21295 24894-24897 IN denotes for
T21296 24898-24910 RB denotes respectively
T21297 24911-24913 CD denotes 21
T21298 24914-24917 CC denotes and
T21299 24918-24920 CD denotes 15
T21300 24921-24925 NN denotes days
T21301 24926-24929 NN denotes p.i
T21302 24931-24934 NN denotes BAL
T21303 24935-24940 NN denotes fluid
T21304 24941-24944 VB denotes was
T21305 24945-24954 VB denotes collected
T21306 24955-24959 IN denotes from
T21307 24960-24964 JJ denotes wild
T21308 24965-24969 NN denotes type
T21309 24970-24971 -LRB- denotes (
T21310 24971-24981 NN denotes A20myel-WT
T21311 24981-24982 -RRB- denotes )
T21312 24983-24986 CC denotes and
T21313 24987-24997 NN denotes A20myel-KO
T21314 24998-25002 NN denotes mice
T21315 25003-25004 CD denotes 6
T21316 25005-25009 NN denotes days
T21317 25010-25019 VB denotes following
T21318 25020-25029 NN denotes infection
T21319 25030-25034 IN denotes with
T21320 25035-25036 DT denotes a
T21321 25037-25043 JJ denotes lethal
T21322 25044-25048 NN denotes dose
T21323 25049-25052 NN denotes IAV
T21324 25053-25056 CC denotes and
T21325 25057-25059 NN denotes KC
T21326 25059-25060 -COMMA- denotes ,
T21327 25061-25066 NN denotes MIP-2
T21328 25066-25067 -COMMA- denotes ,
T21329 25068-25073 NN denotes MCP-1
T21330 25073-25074 -COMMA- denotes ,
T21331 25075-25079 NN denotes IL-6
T21332 25080-25083 CC denotes and
T21333 25084-25088 NN denotes IFNα
T21334 25089-25096 NN denotes protein
T21335 25097-25103 NN denotes levels
T21336 25104-25108 VB denotes were
T21337 25109-25119 VB denotes determined
T21338 25120-25121 -LRB- denotes (
T21339 25121-25122 NN denotes C
T21340 25122-25123 -RRB- denotes )
T21341 25125-25133 JJ denotes Absolute
T21342 25134-25141 NN denotes numbers
T21343 25142-25144 IN denotes of
T21344 25145-25153 JJ denotes alveolar
T21345 25154-25165 NN denotes macrophages
T21346 25165-25166 -COMMA- denotes ,
T21347 25167-25178 NN denotes neutrophils
T21348 25179-25182 CC denotes and
T21349 25183-25192 NN denotes monocytes
T21350 25193-25195 IN denotes in
T21351 25196-25199 NN denotes BAL
T21352 25200-25204 VB denotes were
T21353 25205-25213 VB denotes analyzed
T21354 25214-25216 IN denotes by
T21355 25217-25221 NN denotes flow
T21356 25222-25231 NN denotes cytometry
T21357 25232-25234 IN denotes at
T21358 25235-25236 CD denotes 6
T21359 25237-25241 NN denotes days
T21360 25242-25246 NN denotes p.i.
T21361 25247-25248 -LRB- denotes (
T21362 25248-25249 NN denotes D
T21363 25249-25250 -RRB- denotes )
T21364 25252-25259 NN denotes Numbers
T21365 25260-25263 VB denotes are
T21366 25264-25272 NN denotes averages
T21367 25273-25276 CC denotes +/−
T21368 25277-25280 NN denotes SEM
T21369 25281-25283 IN denotes of
T21370 25284-25286 IN denotes at
T21371 25287-25292 JJ denotes least
T21372 25293-25294 CD denotes 5
T21373 25295-25299 NN denotes mice
T21374 25300-25303 IN denotes per
T21375 25304-25309 NN denotes group
T21376 25311-25315 NN denotes Data
T21377 25316-25319 VB denotes are
T21378 25320-25334 JJ denotes representative
T21379 25335-25337 IN denotes of
T21380 25338-25339 CD denotes 2
T21381 25340-25351 JJ denotes independent
T21382 25352-25364 NN denotes experiments.
T21383 25365-25367 NN denotes *p
T21384 25367-25368 SYM denotes <
T21385 25368-25372 CD denotes 0.05
T21386 25372-25373 -COLON- denotes ;
T21387 25374-25377 NN denotes **p
T21388 25377-25378 SYM denotes <
T21389 25378-25382 CD denotes 0.01
T21390 25382-25383 -COMMA- denotes ,
T21391 25384-25388 NN denotes ***p
T21392 25388-25389 SYM denotes <
T21393 25389-25394 CD denotes 0.001
T11999 25408-25410 IN denotes In
T12000 25411-25414 DT denotes the
T12001 25415-25422 JJ denotes present
T12002 25423-25428 NN denotes study
T12003 25429-25431 PRP denotes we
T12004 25432-25436 VB denotes have
T12005 25437-25449 VB denotes investigated
T12006 25450-25453 DT denotes the
T12007 25454-25466 NN denotes contribution
T12008 25467-25469 IN denotes of
T12009 25470-25473 NN denotes A20
T12010 25474-25484 NN denotes expression
T12011 25485-25487 IN denotes in
T12012 25488-25495 JJ denotes myeloid
T12013 25496-25501 NN denotes cells
T12014 25502-25504 IN denotes in
T12015 25505-25508 DT denotes the
T12016 25509-25515 JJ denotes innate
T12017 25516-25522 JJ denotes immune
T12018 25523-25531 NN denotes response
T12019 25532-25534 TO denotes to
T12020 25535-25538 NN denotes IAV
T12021 25539-25543 NN denotes lung
T12022 25544-25553 NN denotes infection
T12023 25555-25557 IN denotes In
T12024 25558-25561 DT denotes the
T12025 25562-25571 JJ denotes pulmonary
T12026 25572-25583 NN denotes environment
T12027 25583-25584 -COMMA- denotes ,
T12028 25585-25596 NN denotes macrophages
T12029 25597-25605 VB denotes populate
T12030 25606-25610 CC denotes both
T12031 25611-25615 NN denotes lung
T12032 25616-25626 NN denotes parenchyma
T12033 25627-25630 CC denotes and
T12034 25631-25634 DT denotes the
T12035 25635-25643 JJ denotes alveolar
T12036 25644-25649 NN denotes lumen
T12037 25650-25655 WRB denotes where
T12038 25656-25660 PRP denotes they
T12039 25661-25664 VB denotes are
T12040 25665-25673 VB denotes referred
T12041 25674-25676 TO denotes to
T12042 25677-25679 IN denotes as
T12043 25680-25688 JJ denotes alveolar
T12044 25689-25700 NN denotes macrophages
T12045 25702-25707 IN denotes Under
T12046 25708-25713 NN denotes naïve
T12047 25714-25724 NN denotes conditions
T12048 25724-25725 -COMMA- denotes ,
T12049 25726-25734 JJ denotes alveolar
T12050 25735-25746 NN denotes macrophages
T12051 25747-25752 VB denotes exert
T12052 25753-25762 JJ denotes important
T12053 25763-25779 JJ denotes immunomodulatory
T12054 25780-25789 NN denotes functions
T12055 25790-25791 -LRB- denotes [
T12056 25791-25793 CD denotes 65
T12057 25793-25794 -RRB- denotes ]
T12058 25794-25795 -COMMA- denotes ,
T12059 25796-25797 -LRB- denotes [
T12060 25797-25799 CD denotes 66
T12061 25799-25800 -RRB- denotes ]
T12062 25802-25809 RB denotes However
T12063 25809-25810 -COMMA- denotes ,
T12064 25811-25819 JJ denotes alveolar
T12065 25820-25831 NN denotes macrophages
T12066 25832-25835 VB denotes are
T12067 25836-25840 RB denotes also
T12068 25841-25848 JJ denotes crucial
T12069 25849-25851 IN denotes in
T12070 25852-25855 DT denotes the
T12071 25856-25862 JJ denotes innate
T12072 25863-25869 JJ denotes immune
T12073 25870-25878 NN denotes response
T12074 25879-25886 IN denotes against
T12075 25887-25890 NN denotes IAV
T12076 25891-25893 IN denotes as
T12077 25894-25898 PRP denotes they
T12078 25899-25902 VB denotes are
T12079 25903-25906 CD denotes one
T12080 25907-25909 IN denotes of
T12081 25910-25913 DT denotes the
T12082 25914-25919 JJ denotes first
T12083 25920-25925 NN denotes cells
T12084 25926-25930 WDT denotes that
T12085 25931-25940 VB denotes encounter
T12086 25941-25951 JJ denotes infectious
T12087 25952-25955 NN denotes IAV
T12088 25956-25965 NN denotes particles
T12089 25966-25967 -LRB- denotes [
T12090 25967-25969 CD denotes 67
T12091 25969-25970 -RRB- denotes ]
T12092 25970-25971 -COMMA- denotes ,
T12093 25972-25973 -LRB- denotes [
T12094 25973-25975 CD denotes 68
T12095 25975-25976 -RRB- denotes ]
T12096 25978-25982 PRP denotes They
T12097 25983-25986 VB denotes are
T12098 25987-25989 DT denotes an
T12099 25990-25999 JJ denotes important
T12100 26000-26006 NN denotes source
T12101 26007-26009 IN denotes of
T12102 26010-26025 JJ denotes proinflammatory
T12103 26026-26035 NN denotes cytokines
T12104 26036-26039 CC denotes and
T12105 26040-26050 NN denotes chemokines
T12106 26051-26055 WDT denotes that
T12107 26056-26063 VB denotes attract
T12108 26064-26070 JJ denotes innate
T12109 26071-26077 JJ denotes immune
T12110 26078-26083 NN denotes cells
T12111 26084-26086 TO denotes to
T12112 26087-26090 DT denotes the
T12113 26091-26095 NN denotes lung
T12114 26096-26102 IN denotes during
T12115 26103-26106 DT denotes the
T12116 26107-26114 JJ denotes primary
T12117 26115-26120 NN denotes phase
T12118 26121-26123 IN denotes of
T12119 26124-26133 NN denotes infection
T12120 26134-26135 -LRB- denotes [
T12121 26135-26137 CD denotes 69
T12122 26137-26138 -RRB- denotes ]
T12123 26138-26139 -COMMA- denotes ,
T12124 26140-26143 CC denotes and
T12125 26144-26148 PRP denotes they
T12126 26149-26152 VB denotes are
T12127 26153-26156 DT denotes the
T12128 26157-26164 JJ denotes primary
T12129 26165-26174 NN denotes producers
T12130 26175-26177 IN denotes of
T12131 26178-26182 NN denotes type
T12132 26183-26184 CD denotes I
T12133 26185-26189 NN denotes IFNs
T12134 26190-26191 -LRB- denotes [
T12135 26191-26193 CD denotes 70
T12136 26193-26194 -RRB- denotes ]
T12137 26196-26204 JJ denotes Alveolar
T12138 26205-26216 NN denotes macrophages
T12139 26217-26220 VB denotes are
T12140 26221-26225 RB denotes also
T12141 26226-26231 VB denotes known
T12142 26232-26234 TO denotes to
T12143 26235-26246 VB denotes phagocytose
T12144 26247-26252 NN denotes virus
T12145 26253-26261 JJ denotes infected
T12146 26262-26271 JJ denotes apoptotic
T12147 26272-26277 NN denotes cells
T12148 26278-26281 CC denotes and
T12149 26282-26290 NN denotes antibody
T12150 26291-26297 VB denotes coated
T12151 26298-26303 JJ denotes viral
T12152 26304-26313 NN denotes particles
T12153 26313-26314 -COMMA- denotes ,
T12154 26315-26322 RB denotes further
T12155 26323-26335 VB denotes contributing
T12156 26336-26338 TO denotes to
T12157 26339-26344 JJ denotes viral
T12158 26345-26354 NN denotes clearance
T12159 26356-26358 PRP denotes We
T12160 26359-26364 MD denotes could
T12161 26365-26369 VB denotes show
T12162 26370-26374 IN denotes that
T12163 26375-26379 NN denotes BMDM
T12164 26380-26382 CC denotes or
T12165 26383-26391 JJ denotes alveolar
T12166 26392-26403 NN denotes macrophages
T12167 26404-26411 VB denotes derived
T12168 26412-26416 IN denotes from
T12169 26417-26427 NN denotes A20myel-KO
T12170 26428-26432 NN denotes mice
T12171 26433-26440 VB denotes express
T12172 26441-26447 JJ denotes higher
T12173 26448-26455 NN denotes amounts
T12174 26456-26458 IN denotes of
T12175 26459-26469 NN denotes chemokines
T12176 26469-26470 -COMMA- denotes ,
T12177 26471-26480 NN denotes cytokines
T12178 26481-26484 CC denotes and
T12179 26485-26489 NN denotes type
T12180 26490-26491 CD denotes I
T12181 26492-26496 NN denotes IFNs
T12182 26497-26505 VB denotes compared
T12183 26506-26508 TO denotes to
T12184 26509-26513 JJ denotes wild
T12185 26514-26518 NN denotes type
T12186 26519-26523 NN denotes mice
T12187 26524-26526 IN denotes in
T12188 26527-26535 NN denotes response
T12189 26536-26538 TO denotes to
T12190 26539-26541 FW denotes in
T12191 26542-26547 FW denotes vitro
T12192 26548-26557 NN denotes infection
T12193 26559-26568 RB denotes Similarly
T12194 26568-26569 -COMMA- denotes ,
T12195 26570-26572 FW denotes in
T12196 26573-26577 FW denotes vivo
T12197 26578-26587 NN denotes infection
T12198 26588-26592 IN denotes with
T12199 26593-26596 NN denotes IAV
T12200 26597-26605 VB denotes resulted
T12201 26606-26608 IN denotes in
T12202 26609-26615 JJ denotes higher
T12203 26616-26622 NN denotes levels
T12204 26623-26625 IN denotes of
T12205 26626-26635 RB denotes primarily
T12206 26636-26646 NN denotes neutrophil
T12207 26647-26657 VB denotes attracting
T12208 26658-26668 NN denotes chemokines
T12209 26669-26673 JJ denotes such
T12210 26674-26676 IN denotes as
T12211 26677-26679 NN denotes KC
T12212 26680-26683 CC denotes and
T12213 26684-26689 NN denotes MIP-2
T12214 26690-26693 CC denotes and
T12215 26694-26701 JJ denotes several
T12216 26702-26717 JJ denotes proinflammatory
T12217 26718-26727 NN denotes cytokines
T12218 26728-26732 JJ denotes such
T12219 26733-26735 IN denotes as
T12220 26736-26740 NN denotes IL-6
T12221 26740-26741 -COMMA- denotes ,
T12222 26742-26745 NN denotes TNF
T12223 26746-26749 CC denotes and
T12224 26750-26755 NN denotes IL-1β
T12225 26756-26758 IN denotes in
T12226 26759-26762 DT denotes the
T12227 26763-26768 NN denotes lungs
T12228 26769-26771 IN denotes of
T12229 26772-26782 NN denotes A20myel-KO
T12230 26783-26787 NN denotes mice
T12231 26788-26796 VB denotes compared
T12232 26797-26799 TO denotes to
T12233 26800-26804 JJ denotes wild
T12234 26805-26809 NN denotes type
T12235 26810-26814 NN denotes mice
T12236 26816-26820 DT denotes This
T12237 26821-26824 VB denotes was
T12238 26825-26835 VB denotes associated
T12239 26836-26840 IN denotes with
T12240 26841-26842 DT denotes a
T12241 26843-26852 JJ denotes selective
T12242 26853-26864 NN denotes enhancement
T12243 26865-26867 IN denotes of
T12244 26868-26878 NN denotes neutrophil
T12245 26879-26890 NN denotes recruitment
T12246 26891-26893 TO denotes to
T12247 26894-26897 DT denotes the
T12248 26898-26913 JJ denotes bronchoalveolar
T12249 26914-26925 NN denotes compartment
T12250 26925-26926 -COMMA- denotes ,
T12251 26927-26930 CC denotes and
T12252 26931-26939 VB denotes resulted
T12253 26940-26942 IN denotes in
T12254 26943-26951 VB denotes improved
T12255 26952-26957 JJ denotes viral
T12256 26958-26967 NN denotes clearance
T12257 26968-26973 RB denotes later
T12258 26974-26976 IN denotes on
T12259 26977-26983 IN denotes during
T12260 26984-26993 NN denotes infection
T12261 26995-27003 IN denotes Although
T12262 27004-27007 DT denotes the
T12263 27008-27012 NN denotes role
T12264 27013-27015 IN denotes of
T12265 27016-27027 NN denotes neutrophils
T12266 27028-27034 IN denotes during
T12267 27035-27040 JJ denotes viral
T12268 27041-27050 NN denotes infection
T12269 27051-27053 VB denotes is
T12270 27054-27059 RB denotes still
T12271 27060-27065 IN denotes under
T12272 27066-27072 NN denotes debate
T12273 27072-27073 -COMMA- denotes ,
T12274 27074-27080 JJ denotes recent
T12275 27081-27089 NN denotes evidence
T12276 27090-27098 VB denotes supports
T12277 27099-27100 DT denotes a
T12278 27101-27111 JJ denotes protective
T12279 27112-27120 NN denotes function
T12280 27121-27123 IN denotes of
T12281 27124-27129 DT denotes these
T12282 27130-27135 NN denotes cells
T12283 27136-27142 IN denotes during
T12284 27143-27146 NN denotes IAV
T12285 27147-27156 NN denotes infection
T12286 27157-27158 -LRB- denotes [
T12287 27158-27160 CD denotes 71
T12288 27160-27161 -RRB- denotes ]
T12289 27161-27162 -COMMA- denotes ,
T12290 27163-27164 -LRB- denotes [
T12291 27164-27166 CD denotes 72
T12292 27166-27167 -RRB- denotes ]
T12293 27169-27174 NN denotes MCP-1
T12294 27175-27181 NN denotes levels
T12295 27182-27186 VB denotes were
T12296 27187-27190 RB denotes not
T12297 27191-27199 VB denotes affected
T12298 27200-27202 IN denotes by
T12299 27203-27206 DT denotes the
T12300 27207-27214 NN denotes absence
T12301 27215-27217 IN denotes of
T12302 27218-27221 NN denotes A20
T12303 27222-27224 IN denotes in
T12304 27225-27232 JJ denotes myeloid
T12305 27233-27238 NN denotes cells
T12306 27238-27239 -COMMA- denotes ,
T12307 27240-27245 WDT denotes which
T12308 27246-27248 VB denotes is
T12309 27249-27259 JJ denotes consistent
T12310 27260-27264 IN denotes with
T12311 27265-27268 DT denotes the
T12312 27269-27275 NN denotes notion
T12313 27276-27280 IN denotes that
T12314 27281-27287 NN denotes airway
T12315 27288-27298 JJ denotes epithelial
T12316 27299-27304 NN denotes cells
T12317 27305-27308 VB denotes are
T12318 27309-27312 DT denotes the
T12319 27313-27320 JJ denotes primary
T12320 27321-27327 NN denotes source
T12321 27328-27330 IN denotes of
T12322 27331-27336 NN denotes MCP-1
T12323 27337-27347 NN denotes production
T12324 27348-27354 IN denotes during
T12325 27355-27358 NN denotes IAV
T12326 27359-27368 NN denotes infection
T12327 27369-27370 -LRB- denotes [
T12328 27370-27372 CD denotes 73
T12329 27372-27373 -RRB- denotes ]
T12330 27375-27379 NN denotes Mice
T12331 27380-27389 JJ denotes deficient
T12332 27390-27393 IN denotes for
T12333 27394-27397 DT denotes the
T12334 27398-27403 NN denotes MCP-1
T12335 27404-27412 NN denotes receptor
T12336 27413-27417 NN denotes CCR2
T12337 27417-27418 -COMMA- denotes ,
T12338 27419-27424 WDT denotes which
T12339 27425-27427 VB denotes is
T12340 27428-27437 VB denotes expressed
T12341 27438-27440 IN denotes on
T12342 27441-27442 DT denotes a
T12343 27443-27449 NN denotes subset
T12344 27450-27452 IN denotes of
T12345 27453-27464 VB denotes circulating
T12346 27465-27474 NN denotes monocytes
T12347 27474-27475 -COMMA- denotes ,
T12348 27476-27479 VB denotes are
T12349 27480-27489 VB denotes protected
T12350 27490-27497 IN denotes against
T12351 27498-27501 NN denotes IAV
T12352 27502-27511 NN denotes infection
T12353 27512-27515 CC denotes and
T12354 27516-27523 NN denotes display
T12355 27524-27531 VB denotes reduced
T12356 27532-27537 NN denotes signs
T12357 27538-27540 IN denotes of
T12358 27541-27556 NN denotes immunopathology
T12359 27557-27558 -LRB- denotes [
T12360 27558-27560 CD denotes 74
T12361 27560-27561 -RRB- denotes ]
T12362 27561-27562 CD denotes –
T12363 27562-27563 -LRB- denotes [
T12364 27563-27565 CD denotes 76
T12365 27565-27566 -RRB- denotes ]
T12366 27568-27574 IN denotes During
T12367 27575-27578 NN denotes IAV
T12368 27579-27588 NN denotes infection
T12369 27589-27594 DT denotes these
T12370 27595-27604 NN denotes monocytes
T12371 27605-27612 VB denotes develop
T12372 27613-27617 IN denotes into
T12373 27618-27630 JJ denotes inflammatory
T12374 27631-27640 JJ denotes dendritic
T12375 27641-27646 NN denotes cells
T12376 27647-27649 CC denotes or
T12377 27650-27665 JJ denotes proinflammatory
T12378 27666-27677 NN denotes macrophages
T12379 27678-27679 -LRB- denotes [
T12380 27679-27681 CD denotes 77
T12381 27681-27682 -RRB- denotes ]
T12382 27683-27686 CC denotes and
T12383 27687-27690 VB denotes are
T12384 27691-27701 VB denotes considered
T12385 27702-27707 JJ denotes major
T12386 27708-27720 NN denotes contributors
T12387 27721-27723 TO denotes to
T12388 27724-27735 JJ denotes IAV-induced
T12389 27736-27751 NN denotes immunopathology
T12390 27752-27753 -LRB- denotes [
T12391 27753-27755 CD denotes 78
T12392 27755-27756 -RRB- denotes ]
T12393 27758-27768 NN denotes A20myel-KO
T12394 27769-27773 NN denotes mice
T12395 27774-27778 VB denotes were
T12396 27779-27788 VB denotes protected
T12397 27789-27796 IN denotes against
T12398 27797-27798 DT denotes a
T12399 27799-27805 JJ denotes lethal
T12400 27806-27809 NN denotes IAV
T12401 27810-27819 NN denotes infection
T12402 27819-27820 -COMMA- denotes ,
T12403 27821-27826 WDT denotes which
T12404 27827-27829 VB denotes is
T12405 27830-27836 RB denotes rather
T12406 27837-27847 JJ denotes surprising
T12407 27848-27853 IN denotes since
T12408 27854-27856 DT denotes an
T12409 27857-27866 JJ denotes excessive
T12410 27867-27882 JJ denotes proinflammatory
T12411 27883-27891 NN denotes cytokine
T12412 27892-27900 NN denotes response
T12413 27901-27904 CC denotes and
T12414 27905-27907 DT denotes an
T12415 27908-27917 JJ denotes excessive
T12416 27918-27924 NN denotes influx
T12417 27925-27927 IN denotes of
T12418 27928-27940 JJ denotes inflammatory
T12419 27941-27946 NN denotes cells
T12420 27947-27949 VB denotes is
T12421 27950-27959 RB denotes generally
T12422 27960-27968 VB denotes believed
T12423 27969-27971 TO denotes to
T12424 27972-27974 VB denotes be
T12425 27975-27985 VB denotes associated
T12426 27986-27990 IN denotes with
T12427 27991-28000 VB denotes increased
T12428 28001-28010 NN denotes lethality
T12429 28011-28012 -LRB- denotes [
T12430 28012-28014 CD denotes 64
T12431 28014-28015 -RRB- denotes ]
T12432 28015-28016 -COMMA- denotes ,
T12433 28017-28018 -LRB- denotes [
T12434 28018-28020 CD denotes 79
T12435 28020-28021 -RRB- denotes ]
T12436 28023-28030 RB denotes However
T12437 28030-28031 -COMMA- denotes ,
T12438 28032-28035 DT denotes the
T12439 28036-28045 JJ denotes selective
T12440 28046-28052 NN denotes effect
T12441 28053-28055 IN denotes of
T12442 28056-28059 NN denotes A20
T12443 28060-28070 NN denotes deficiency
T12444 28071-28073 IN denotes on
T12445 28074-28084 NN denotes neutrophil
T12446 28085-28096 NN denotes recruitment
T12447 28096-28097 -COMMA- denotes ,
T12448 28098-28105 IN denotes without
T12449 28106-28114 VB denotes altering
T12450 28115-28127 JJ denotes inflammatory
T12451 28128-28136 NN denotes monocyte
T12452 28137-28138 -LRB- denotes (
T12453 28138-28143 JJ denotes Ly6C+
T12454 28144-28150 NN denotes CD11b+
T12455 28150-28151 -RRB- denotes )
T12456 28152-28163 NN denotes recruitment
T12457 28163-28164 -COMMA- denotes ,
T12458 28165-28172 RB denotes further
T12459 28173-28180 VB denotes support
T12460 28181-28184 DT denotes the
T12461 28185-28189 NN denotes idea
T12462 28190-28194 IN denotes that
T12463 28195-28204 NN denotes monocytes
T12464 28205-28208 CC denotes and
T12465 28209-28212 RB denotes not
T12466 28213-28224 NN denotes neutrophils
T12467 28225-28228 VB denotes are
T12468 28229-28234 JJ denotes major
T12469 28235-28247 NN denotes contributors
T12470 28248-28250 TO denotes to
T12471 28251-28265 JJ denotes IAV-associated
T12472 28266-28281 NN denotes immunopathology
T12473 28282-28285 CC denotes and
T12474 28286-28295 NN denotes lethality
T12475 28296-28297 -LRB- denotes [
T12476 28297-28299 CD denotes 78
T12477 28299-28300 -RRB- denotes ]
T12478 28302-28304 PRP denotes We
T12479 28305-28309 VB denotes show
T12480 28310-28314 IN denotes that
T12481 28315-28318 NN denotes A20
T12482 28319-28328 JJ denotes deficient
T12483 28329-28333 NN denotes BMDM
T12484 28334-28341 NN denotes display
T12485 28342-28350 VB denotes enhanced
T12486 28351-28356 NN denotes NF-κB
T12487 28357-28360 CC denotes and
T12488 28361-28365 NN denotes IRF3
T12489 28366-28376 NN denotes activation
T12490 28377-28379 IN denotes in
T12491 28380-28388 NN denotes response
T12492 28389-28391 TO denotes to
T12493 28392-28397 NN denotes RIG-I
T12494 28398-28409 NN denotes stimulation
T12495 28410-28412 IN denotes by
T12496 28413-28422 JJ denotes synthetic
T12497 28423-28426 NN denotes LMW
T12498 28427-28433 JJ denotes double
T12499 28434-28442 JJ denotes stranded
T12500 28443-28446 NN denotes RNA
T12501 28448-28453 NN denotes RIG-I
T12502 28454-28457 VB denotes has
T12503 28458-28468 RB denotes previously
T12504 28469-28473 VB denotes been
T12505 28474-28479 VB denotes shown
T12506 28480-28482 TO denotes to
T12507 28483-28487 VB denotes play
T12508 28488-28489 DT denotes a
T12509 28490-28493 JJ denotes key
T12510 28494-28498 NN denotes role
T12511 28499-28501 IN denotes in
T12512 28502-28505 DT denotes the
T12513 28506-28512 JJ denotes innate
T12514 28513-28519 JJ denotes immune
T12515 28520-28528 NN denotes response
T12516 28529-28531 TO denotes to
T12517 28532-28535 NN denotes IAV
T12518 28536-28537 -LRB- denotes [
T12519 28537-28539 CD denotes 13
T12520 28539-28540 -RRB- denotes ]
T12521 28540-28541 -COMMA- denotes ,
T12522 28542-28552 VB denotes suggesting
T12523 28553-28557 IN denotes that
T12524 28558-28561 DT denotes the
T12525 28562-28571 VB denotes increased
T12526 28572-28578 JJ denotes immune
T12527 28579-28587 NN denotes response
T12528 28588-28590 IN denotes of
T12529 28591-28601 NN denotes A20myel-KO
T12530 28602-28606 NN denotes mice
T12531 28607-28609 TO denotes to
T12532 28610-28613 NN denotes IAV
T12533 28614-28618 NN denotes lung
T12534 28619-28628 NN denotes infection
T12535 28629-28637 VB denotes reflects
T12536 28638-28646 VB denotes enhanced
T12537 28647-28652 NN denotes RIG-I
T12538 28653-28662 NN denotes signaling
T12539 28664-28666 PRP denotes We
T12540 28667-28674 VB denotes propose
T12541 28675-28679 IN denotes that
T12542 28680-28683 NN denotes A20
T12543 28684-28692 VB denotes inhibits
T12544 28693-28704 JJ denotes IAV-induced
T12545 28705-28720 JJ denotes proinflammatory
T12546 28721-28725 NN denotes gene
T12547 28726-28736 NN denotes expression
T12548 28737-28738 -LRB- denotes (
T12549 28738-28740 IN denotes as
T12550 28741-28746 VB denotes shown
T12551 28747-28749 IN denotes in
T12552 28750-28753 PRP-DOLLAR- denotes our
T12553 28754-28764 NN denotes manuscript
T12554 28765-28768 IN denotes for
T12555 28769-28772 NN denotes TNF
T12556 28772-28773 -COMMA- denotes ,
T12557 28774-28778 NN denotes IL-6
T12558 28778-28779 -COMMA- denotes ,
T12559 28780-28782 NN denotes KC
T12560 28782-28783 -COMMA- denotes ,
T12561 28784-28789 NN denotes MIP-2
T12562 28789-28790 -COMMA- denotes ,
T12563 28791-28794 CC denotes and
T12564 28795-28799 NN denotes IFNβ
T12565 28799-28800 -RRB- denotes )
T12566 28801-28803 IN denotes by
T12567 28804-28814 RB denotes negatively
T12568 28815-28825 VB denotes regulating
T12569 28826-28831 NN denotes NF-κB
T12570 28832-28835 CC denotes and
T12571 28836-28840 NN denotes IRF3
T12572 28841-28851 NN denotes activation
T12573 28851-28852 -COMMA- denotes ,
T12574 28853-28858 WDT denotes which
T12575 28859-28862 VB denotes are
T12576 28863-28866 DT denotes the
T12577 28867-28872 JJ denotes major
T12578 28873-28881 NN denotes pathways
T12579 28882-28893 VB denotes controlling
T12580 28894-28899 DT denotes these
T12581 28900-28905 NN denotes genes
T12582 28907-28914 RB denotes However
T12583 28914-28915 -COMMA- denotes ,
T12584 28916-28920 DT denotes this
T12585 28921-28925 VB denotes does
T12586 28926-28929 RB denotes not
T12587 28930-28937 VB denotes exclude
T12588 28938-28940 DT denotes an
T12589 28941-28951 JJ denotes additional
T12590 28952-28958 NN denotes effect
T12591 28959-28961 IN denotes of
T12592 28962-28965 NN denotes A20
T12593 28966-28968 IN denotes on
T12594 28969-28974 JJ denotes other
T12595 28975-28984 NN denotes signaling
T12596 28985-28993 NN denotes pathways
T12597 28994-28998 WDT denotes that
T12598 28999-29002 MD denotes may
T12599 29003-29013 VB denotes contribute
T12600 29014-29016 TO denotes to
T12601 29017-29032 JJ denotes proinflammatory
T12602 29033-29037 NN denotes gene
T12603 29038-29048 NN denotes expression
T12604 29050-29053 NN denotes A20
T12605 29054-29056 VB denotes is
T12606 29057-29065 VB denotes believed
T12607 29066-29068 TO denotes to
T12608 29069-29074 VB denotes exert
T12609 29075-29078 PRP-DOLLAR- denotes its
T12610 29079-29084 NN denotes NF-κB
T12611 29085-29088 CC denotes and
T12612 29089-29093 NN denotes IRF3
T12613 29094-29104 JJ denotes inhibitory
T12614 29105-29114 NN denotes functions
T12615 29115-29117 IN denotes by
T12616 29118-29128 VB denotes modulating
T12617 29129-29132 DT denotes the
T12618 29133-29147 NN denotes ubiquitination
T12619 29148-29154 NN denotes status
T12620 29155-29157 IN denotes of
T12621 29158-29167 JJ denotes different
T12622 29168-29177 NN denotes signaling
T12623 29178-29186 NN denotes proteins
T12624 29187-29188 -LRB- denotes [
T12625 29188-29190 CD denotes 80
T12626 29190-29191 -RRB- denotes ]
T12627 29193-29195 IN denotes In
T12628 29196-29200 DT denotes this
T12629 29201-29208 NN denotes context
T12630 29208-29209 -COMMA- denotes ,
T12631 29210-29212 PRP denotes it
T12632 29213-29216 VB denotes was
T12633 29217-29225 RB denotes recently
T12634 29226-29231 VB denotes shown
T12635 29232-29236 IN denotes that
T12636 29237-29240 NN denotes A20
T12637 29241-29251 VB denotes cooperates
T12638 29252-29256 IN denotes with
T12639 29257-29260 DT denotes the
T12640 29261-29278 JJ denotes ubiquitin-binding
T12641 29279-29287 NN denotes proteins
T12642 29288-29295 NN denotes TAX1BP1
T12643 29296-29299 CC denotes and
T12644 29300-29305 NN denotes ABIN1
T12645 29306-29308 TO denotes to
T12646 29309-29311 TO denotes to
T12647 29312-29319 VB denotes disrupt
T12648 29320-29323 DT denotes the
T12649 29324-29339 NN denotes TRAF3-TBK1-IKKε
T12650 29340-29347 NN denotes complex
T12651 29347-29348 -COMMA- denotes ,
T12652 29349-29356 RB denotes thereby
T12653 29357-29367 RB denotes negatively
T12654 29368-29377 VB denotes affecting
T12655 29378-29400 NN denotes K63-polyubiquitination
T12656 29401-29403 IN denotes of
T12657 29404-29408 NN denotes TBK1
T12658 29409-29412 CC denotes and
T12659 29413-29417 NN denotes IKKε
T12660 29417-29418 -COMMA- denotes ,
T12661 29419-29422 CC denotes and
T12662 29423-29428 PRP-DOLLAR- denotes their
T12663 29429-29436 NN denotes ability
T12664 29437-29439 TO denotes to
T12665 29440-29448 NN denotes activity
T12666 29449-29453 NN denotes IRF3
T12667 29454-29455 -LRB- denotes [
T12668 29455-29457 CD denotes 81
T12669 29457-29458 -RRB- denotes ]
T12670 29458-29459 -COMMA- denotes ,
T12671 29460-29461 -LRB- denotes [
T12672 29461-29463 CD denotes 82
T12673 29463-29464 -RRB- denotes ]
T12674 29466-29473 IN denotes Whether
T12675 29474-29481 JJ denotes similar
T12676 29482-29492 NN denotes mechanisms
T12677 29493-29496 VB denotes are
T12678 29497-29505 VB denotes involved
T12679 29506-29508 IN denotes in
T12680 29509-29512 DT denotes the
T12681 29513-29523 NN denotes regulation
T12682 29524-29526 IN denotes of
T12683 29527-29532 NN denotes RIG-I
T12684 29533-29540 VB denotes induced
T12685 29541-29546 NN denotes NF-κB
T12686 29547-29557 NN denotes activation
T12687 29558-29560 VB denotes is
T12688 29561-29566 RB denotes still
T12689 29567-29574 JJ denotes unclear
T12690 29576-29578 RB denotes So
T12691 29579-29582 RB denotes far
T12692 29583-29585 PRP denotes we
T12693 29586-29590 VB denotes were
T12694 29591-29597 JJ denotes unable
T12695 29598-29600 TO denotes to
T12696 29601-29608 RB denotes clearly
T12697 29609-29615 VB denotes detect
T12698 29616-29630 NN denotes ubiquitination
T12699 29631-29633 IN denotes of
T12700 29634-29638 NN denotes TBK1
T12701 29639-29642 CC denotes and
T12702 29643-29647 NN denotes IKKε
T12703 29648-29650 IN denotes in
T12704 29651-29658 JJ denotes primary
T12705 29659-29670 NN denotes macrophages
T12706 29670-29671 -COMMA- denotes ,
T12707 29672-29682 VB denotes preventing
T12708 29683-29685 PRP denotes us
T12709 29686-29690 IN denotes from
T12710 29691-29699 VB denotes studying
T12711 29700-29703 DT denotes the
T12712 29704-29710 NN denotes effect
T12713 29711-29713 IN denotes of
T12714 29714-29717 NN denotes A20
T12715 29718-29728 NN denotes deficiency
T12716 29729-29731 IN denotes on
T12717 29732-29737 PRP-DOLLAR- denotes their
T12718 29738-29752 NN denotes ubiquitination
T12719 29753-29759 NN denotes status
T12720 29761-29763 PRP denotes It
T12721 29764-29767 MD denotes can
T12722 29767-29770 RB denotes not
T12723 29771-29773 VB denotes be
T12724 29774-29782 VB denotes excluded
T12725 29783-29790 RB denotes however
T12726 29791-29795 IN denotes that
T12727 29796-29799 NN denotes A20
T12728 29800-29804 RB denotes also
T12729 29805-29812 VB denotes targets
T12730 29813-29818 JJ denotes other
T12731 29819-29829 NN denotes substrates
T12732 29830-29834 WDT denotes that
T12733 29835-29842 VB denotes mediate
T12734 29843-29848 NN denotes NF-κB
T12735 29849-29852 CC denotes and
T12736 29853-29857 NN denotes IRF3
T12737 29858-29868 NN denotes activation
T12738 29869-29871 IN denotes in
T12739 29872-29879 JJ denotes myeloid
T12740 29880-29885 NN denotes cells
T12741 29887-29890 DT denotes The
T12742 29891-29905 NN denotes identification
T12743 29906-29908 IN denotes of
T12744 29909-29914 DT denotes these
T12745 29915-29925 NN denotes substrates
T12746 29926-29930 MD denotes will
T12747 29931-29933 VB denotes be
T12748 29934-29937 DT denotes the
T12749 29938-29943 NN denotes topic
T12750 29944-29946 IN denotes of
T12751 29947-29953 JJ denotes future
T12752 29954-29968 NN denotes investigations
T12753 29969-29971 IN denotes in
T12754 29972-29975 PRP-DOLLAR- denotes our
T12755 29976-29986 NN denotes laboratory
T12756 29988-29996 JJ denotes Multiple
T12757 29997-30002 JJ denotes other
T12758 30003-30019 VB denotes deubiquitinating
T12759 30020-30027 NN denotes enzymes
T12760 30028-30029 -LRB- denotes (
T12761 30029-30033 NN denotes DUBs
T12762 30033-30034 -RRB- denotes )
T12763 30034-30035 -COMMA- denotes ,
T12764 30036-30040 JJ denotes such
T12765 30041-30043 IN denotes as
T12766 30044-30048 NNP denotes DUBA
T12767 30049-30050 -LRB- denotes [
T12768 30050-30052 CD denotes 28
T12769 30052-30053 -RRB- denotes ]
T12770 30053-30054 -COMMA- denotes ,
T12771 30055-30059 NN denotes CYLD
T12772 30060-30061 -LRB- denotes [
T12773 30061-30063 CD denotes 29
T12774 30063-30064 -RRB- denotes ]
T12775 30064-30065 -COMMA- denotes ,
T12776 30066-30067 -LRB- denotes [
T12777 30067-30069 CD denotes 30
T12778 30069-30070 -RRB- denotes ]
T12779 30070-30071 -COMMA- denotes ,
T12780 30072-30079 CD denotes OTUB1/2
T12781 30080-30081 -LRB- denotes [
T12782 30081-30083 CD denotes 31
T12783 30083-30084 -RRB- denotes ]
T12784 30084-30085 -COMMA- denotes ,
T12785 30086-30089 CC denotes and
T12786 30090-30093 NN denotes A20
T12787 30094-30095 -LRB- denotes [
T12788 30095-30097 CD denotes 49
T12789 30097-30098 -RRB- denotes ]
T12790 30098-30099 CD denotes –
T12791 30099-30100 -LRB- denotes [
T12792 30100-30102 CD denotes 52
T12793 30102-30103 -RRB- denotes ]
T12794 30104-30108 VB denotes have
T12795 30109-30113 VB denotes been
T12796 30114-30119 VB denotes shown
T12797 30120-30122 TO denotes to
T12798 30123-30133 RB denotes negatively
T12799 30134-30142 VB denotes regulate
T12800 30143-30148 NN denotes RIG-I
T12801 30149-30158 NN denotes signaling
T12802 30159-30161 TO denotes to
T12803 30162-30167 NN denotes NF-κB
T12804 30168-30171 CC denotes and
T12805 30172-30177 NN denotes IRF-3
T12806 30177-30178 -COMMA- denotes ,
T12807 30179-30190 VB denotes implicating
T12808 30191-30199 JJ denotes possible
T12809 30200-30210 NN denotes redundancy
T12810 30212-30219 RB denotes However
T12811 30219-30220 -COMMA- denotes ,
T12812 30221-30229 NN denotes evidence
T12813 30230-30232 RB denotes so
T12814 30233-30236 RB denotes far
T12815 30237-30240 VB denotes was
T12816 30241-30248 VB denotes limited
T12817 30249-30251 TO denotes to
T12818 30252-30254 FW denotes in
T12819 30255-30260 FW denotes vitro
T12820 30261-30265 NN denotes data
T12821 30266-30269 CC denotes and
T12822 30270-30273 VB denotes was
T12823 30274-30282 VB denotes obtained
T12824 30283-30288 IN denotes under
T12825 30289-30306 JJ denotes non-physiological
T12826 30307-30317 NN denotes conditions
T12827 30319-30322 DT denotes The
T12828 30323-30328 JJ denotes clear
T12829 30329-30339 JJ denotes protective
T12830 30340-30349 NN denotes phenotype
T12831 30350-30352 IN denotes of
T12832 30353-30363 NN denotes A20myel-KO
T12833 30364-30368 NN denotes mice
T12834 30369-30373 IN denotes that
T12835 30374-30376 PRP denotes we
T12836 30377-30381 RB denotes here
T12837 30382-30390 VB denotes describe
T12838 30391-30400 VB denotes indicates
T12839 30401-30405 IN denotes that
T12840 30406-30409 NN denotes A20
T12841 30410-30420 NN denotes expression
T12842 30421-30423 IN denotes in
T12843 30424-30431 JJ denotes myeloid
T12844 30432-30437 NN denotes cells
T12845 30438-30440 VB denotes is
T12846 30441-30442 DT denotes a
T12847 30443-30450 JJ denotes central
T12848 30451-30461 NN denotes gatekeeper
T12849 30462-30464 IN denotes of
T12850 30465-30470 NN denotes RIG-I
T12851 30471-30478 VB denotes induced
T12852 30479-30488 NN denotes signaling
T12853 30489-30491 IN denotes in
T12854 30492-30500 NN denotes response
T12855 30501-30503 TO denotes to
T12856 30504-30507 NN denotes IAV
T12857 30508-30517 NN denotes infection
T12858 30518-30521 CC denotes and
T12859 30522-30526 IN denotes that
T12860 30527-30532 JJ denotes other
T12861 30533-30537 NN denotes DUBs
T12862 30538-30541 MD denotes can
T12863 30541-30544 RB denotes not
T12864 30545-30555 VB denotes substitute
T12865 30556-30559 IN denotes for
T12866 30560-30563 NN denotes A20
T12867 30564-30574 NN denotes deficiency
T12868 30575-30580 IN denotes under
T12869 30581-30594 JJ denotes physiological
T12870 30595-30605 NN denotes conditions
T12871 30607-30609 IN denotes If
T12872 30610-30613 NN denotes A20
T12873 30614-30617 VB denotes has
T12874 30618-30619 DT denotes a
T12875 30620-30627 JJ denotes similar
T12876 30628-30641 JJ denotes non-redundant
T12877 30642-30646 NN denotes role
T12878 30647-30649 IN denotes in
T12879 30650-30655 JJ denotes other
T12880 30656-30660 NN denotes cell
T12881 30661-30666 NN denotes types
T12882 30667-30671 WDT denotes that
T12883 30672-30675 VB denotes are
T12884 30676-30686 VB denotes implicated
T12885 30687-30689 IN denotes in
T12886 30690-30693 DT denotes the
T12887 30694-30702 NN denotes response
T12888 30703-30705 TO denotes to
T12889 30706-30709 NN denotes IAV
T12890 30709-30710 -COMMA- denotes ,
T12891 30711-30715 JJ denotes such
T12892 30716-30718 IN denotes as
T12893 30719-30723 NN denotes lung
T12894 30724-30734 JJ denotes epithelial
T12895 30735-30740 NN denotes cells
T12896 30740-30741 -COMMA- denotes ,
T12897 30742-30749 VB denotes remains
T12898 30750-30752 TO denotes to
T12899 30753-30755 VB denotes be
T12900 30756-30768 VB denotes investigated
T12901 30770-30783 VB denotes Understanding
T12902 30784-30787 CC denotes and
T12903 30788-30799 VB denotes controlling
T12904 30800-30803 DT denotes the
T12905 30804-30814 NN denotes activation
T12906 30815-30817 IN denotes of
T12907 30818-30824 JJ denotes innate
T12908 30825-30834 JJ denotes antiviral
T12909 30835-30841 JJ denotes immune
T12910 30842-30851 NN denotes responses
T12911 30852-30854 VB denotes is
T12912 30855-30857 DT denotes an
T12913 30858-30867 JJ denotes important
T12914 30868-30872 NN denotes step
T12915 30873-30879 IN denotes toward
T12916 30880-30885 JJ denotes novel
T12917 30886-30895 NN denotes therapies
T12918 30897-30902 IN denotes About
T12919 30903-30904 DT denotes a
T12920 30905-30910 NN denotes fifth
T12921 30911-30913 IN denotes of
T12922 30914-30919 NN denotes world
T12923 30919-30921 POS denotes 's
T12924 30922-30932 NN denotes population
T12925 30933-30935 VB denotes is
T12926 30936-30944 VB denotes infected
T12927 30945-30947 IN denotes by
T12928 30948-30951 NN denotes IAV
T12929 30952-30960 RB denotes annually
T12930 30960-30961 -COMMA- denotes ,
T12931 30962-30969 VB denotes leading
T12932 30970-30972 TO denotes to
T12933 30973-30977 JJ denotes high
T12934 30978-30987 NN denotes morbidity
T12935 30988-30991 CC denotes and
T12936 30992-31001 NN denotes mortality
T12937 31001-31002 -COMMA- denotes ,
T12938 31003-31015 RB denotes particularly
T12939 31016-31018 IN denotes in
T12940 31019-31026 NN denotes infants
T12941 31026-31027 -COMMA- denotes ,
T12942 31028-31031 DT denotes the
T12943 31032-31039 JJ denotes elderly
T12944 31040-31043 CC denotes and
T12945 31044-31047 DT denotes the
T12946 31048-31065 JJ denotes immunocompromised
T12947 31067-31070 DT denotes The
T12948 31071-31075 JJ denotes high
T12949 31076-31084 NN denotes mutation
T12950 31085-31089 NN denotes rate
T12951 31090-31092 IN denotes of
T12952 31093-31096 NN denotes IAV
T12953 31097-31102 VB denotes turns
T12954 31103-31106 DT denotes all
T12955 31107-31115 NN denotes attempts
T12956 31116-31118 IN denotes of
T12957 31119-31126 NN denotes vaccine
T12958 31127-31130 CC denotes and
T12959 31131-31140 JJ denotes antiviral
T12960 31141-31147 NN denotes design
T12961 31148-31152 IN denotes into
T12962 31153-31154 DT denotes a
T12963 31155-31160 RB denotes never
T12964 31161-31167 VB denotes ending
T12965 31168-31174 NN denotes battle
T12966 31176-31178 IN denotes In
T12967 31179-31185 JJ denotes recent
T12968 31186-31191 NN denotes years
T12969 31191-31192 -COMMA- denotes ,
T12970 31193-31196 NN denotes RNA
T12971 31197-31209 NN denotes interference
T12972 31209-31210 -COMMA- denotes ,
T12973 31211-31220 VB denotes triggered
T12974 31221-31223 IN denotes by
T12975 31224-31233 JJ denotes synthetic
T12976 31234-31239 JJ denotes short
T12977 31240-31251 VB denotes interfering
T12978 31252-31255 NN denotes RNA
T12979 31256-31257 -LRB- denotes (
T12980 31257-31262 NN denotes siRNA
T12981 31262-31263 -RRB- denotes )
T12982 31263-31264 -COMMA- denotes ,
T12983 31265-31268 VB denotes has
T12984 31269-31276 RB denotes rapidly
T12985 31277-31284 VB denotes evolved
T12986 31285-31287 IN denotes as
T12987 31288-31289 DT denotes a
T12988 31290-31296 JJ denotes potent
T12989 31297-31306 JJ denotes antiviral
T12990 31307-31314 NN denotes regimen
T12991 31316-31324 RB denotes Properly
T12992 31325-31333 VB denotes designed
T12993 31334-31340 NN denotes siRNAs
T12994 31341-31345 VB denotes have
T12995 31346-31350 VB denotes been
T12996 31351-31356 VB denotes shown
T12997 31357-31359 TO denotes to
T12998 31360-31368 VB denotes function
T12999 31369-31371 IN denotes as
T13000 31372-31378 JJ denotes potent
T13001 31379-31389 NN denotes inhibitors
T13002 31390-31392 IN denotes of
T13003 31393-31402 NN denotes influenza
T13004 31403-31408 NN denotes virus
T13005 31409-31420 NN denotes replication
T13006 31422-31430 IN denotes Although
T13007 31431-31442 NN denotes specificity
T13008 31443-31446 CC denotes and
T13009 31447-31453 NN denotes tissue
T13010 31454-31462 NN denotes delivery
T13011 31463-31469 VB denotes remain
T13012 31470-31475 JJ denotes major
T13013 31476-31487 NN denotes bottlenecks
T13014 31488-31490 IN denotes in
T13015 31491-31494 DT denotes the
T13016 31495-31503 JJ denotes clinical
T13017 31504-31516 NN denotes applications
T13018 31517-31519 IN denotes of
T13019 31520-31524 NN denotes RNAi
T13020 31525-31527 IN denotes in
T13021 31528-31535 JJ denotes general
T13022 31535-31536 -COMMA- denotes ,
T13023 31537-31547 JJ denotes intranasal
T13024 31548-31559 NN denotes application
T13025 31560-31562 IN denotes of
T13026 31563-31568 NN denotes siRNA
T13027 31569-31576 IN denotes against
T13028 31577-31588 JJ denotes respiratory
T13029 31589-31596 NN denotes viruses
T13030 31597-31606 VB denotes including
T13031 31606-31607 -COMMA- denotes ,
T13032 31608-31611 CC denotes but
T13033 31612-31615 RB denotes not
T13034 31616-31623 VB denotes limited
T13035 31624-31626 TO denotes to
T13036 31627-31636 NN denotes influenza
T13037 31637-31642 NN denotes virus
T13038 31642-31643 -COMMA- denotes ,
T13039 31644-31647 VB denotes has
T13040 31648-31659 VB denotes experienced
T13041 31660-31671 JJ denotes significant
T13042 31672-31679 NN denotes success
T13043 31680-31683 CC denotes and
T13044 31684-31692 NN denotes optimism
T13045 31693-31694 -LRB- denotes [
T13046 31694-31696 CD denotes 83
T13047 31696-31697 -RRB- denotes ]
T13048 31699-31702 PRP-DOLLAR- denotes Our
T13049 31703-31710 NN denotes results
T13050 31711-31718 VB denotes suggest
T13051 31719-31723 IN denotes that
T13052 31724-31727 RB denotes not
T13053 31728-31732 RB denotes only
T13054 31733-31738 NN denotes siRNA
T13055 31739-31748 VB denotes targeting
T13056 31749-31752 NN denotes IAV
T13057 31753-31763 NN denotes components
T13058 31763-31764 -COMMA- denotes ,
T13059 31765-31768 CC denotes but
T13060 31769-31777 VB denotes boosting
T13061 31778-31781 DT denotes the
T13062 31782-31791 JJ denotes antiviral
T13063 31792-31798 JJ denotes immune
T13064 31799-31807 NN denotes response
T13065 31808-31810 IN denotes by
T13066 31811-31821 JJ denotes intranasal
T13067 31822-31836 NN denotes administration
T13068 31837-31839 IN denotes of
T13069 31840-31845 NN denotes siRNA
T13070 31846-31853 IN denotes against
T13071 31854-31857 NN denotes A20
T13072 31858-31863 MD denotes might
T13073 31864-31866 VB denotes be
T13074 31867-31868 DT denotes a
T13075 31869-31874 JJ denotes valid
T13076 31875-31886 JJ denotes therapeutic
T13077 31887-31895 NN denotes approach
T13078 31897-31901 RB denotes Also
T13079 31902-31907 JJ denotes small
T13080 31908-31916 NN denotes compound
T13081 31917-31927 NN denotes inhibitors
T13082 31928-31930 IN denotes of
T13083 31931-31934 NN denotes A20
T13084 31935-31940 MD denotes might
T13085 31941-31943 VB denotes be
T13086 31944-31946 DT denotes an
T13087 31947-31958 JJ denotes interesting
T13088 31959-31970 NN denotes alternative
T13089 31972-31979 RB denotes Finally
T13090 31979-31980 -COMMA- denotes ,
T13091 31981-31988 JJ denotes similar
T13092 31989-31998 NN denotes targeting
T13093 31999-32001 IN denotes of
T13094 32002-32005 NN denotes A20
T13095 32006-32011 MD denotes might
T13096 32012-32014 VB denotes be
T13097 32015-32017 IN denotes of
T13098 32018-32026 NN denotes interest
T13099 32027-32029 IN denotes in
T13100 32030-32033 DT denotes the
T13101 32034-32040 NN denotes battle
T13102 32041-32048 IN denotes against
T13103 32049-32054 JJ denotes other
T13104 32055-32060 JJ denotes viral
T13105 32061-32071 NN denotes infections
T13106 32072-32081 VB denotes including
T13107 32082-32085 NN denotes RSV
T13108 32086-32089 CC denotes and
T13109 32090-32094 NN denotes SARS
T13110 32095-32106 NN denotes coronavirus
T14802 32132-32138 NN denotes Ethics
T14803 32139-32148 NN denotes statement
T14804 32149-32152 DT denotes All
T14805 32153-32164 NN denotes experiments
T14806 32165-32167 IN denotes on
T14807 32168-32172 NN denotes mice
T14808 32173-32177 VB denotes were
T14809 32178-32187 VB denotes conducted
T14810 32188-32197 VB denotes according
T14811 32198-32200 TO denotes to
T14812 32201-32204 DT denotes the
T14813 32205-32213 JJ denotes national
T14814 32214-32215 -LRB- denotes (
T14815 32215-32222 JJ denotes Belgian
T14816 32223-32226 NN denotes Law
T14817 32227-32237 CD denotes 14/08/1986
T14818 32238-32241 CC denotes and
T14819 32242-32252 CD denotes 22/12/2003
T14820 32252-32253 -COMMA- denotes ,
T14821 32254-32261 NNP denotes Belgian
T14822 32262-32267 NNP denotes Royal
T14823 32268-32274 NNP denotes Decree
T14824 32275-32285 CD denotes 06/04/2010
T14825 32285-32286 -RRB- denotes )
T14826 32287-32290 CC denotes and
T14827 32291-32299 JJ denotes European
T14828 32300-32301 -LRB- denotes (
T14829 32301-32303 NN denotes EU
T14830 32304-32314 NN denotes Directives
T14831 32315-32325 NN denotes 2010/63/EU
T14832 32325-32326 -COMMA- denotes ,
T14833 32327-32337 NN denotes 86/609/EEG
T14834 32337-32338 -RRB- denotes )
T14835 32339-32345 NN denotes animal
T14836 32346-32357 NN denotes regulations
T14837 32359-32365 NN denotes Animal
T14838 32366-32375 NN denotes protocols
T14839 32376-32380 VB denotes were
T14840 32381-32389 VB denotes approved
T14841 32390-32392 IN denotes by
T14842 32393-32396 DT denotes the
T14843 32397-32403 NN denotes ethics
T14844 32404-32413 NN denotes committee
T14845 32414-32416 IN denotes of
T14846 32417-32422 NNP denotes Ghent
T14847 32423-32433 NNP denotes University
T14848 32434-32435 -LRB- denotes (
T14849 32435-32441 NN denotes permit
T14850 32442-32448 NN denotes number
T14851 32449-32458 NN denotes LA1400091
T14852 32458-32459 -COMMA- denotes ,
T14853 32460-32468 NN denotes approval
T14854 32469-32471 NN denotes ID
T14855 32472-32480 CD denotes 2010/001
T14856 32480-32481 -RRB- denotes )
T14857 32483-32486 DT denotes All
T14858 32487-32494 NN denotes efforts
T14859 32495-32499 VB denotes were
T14860 32500-32504 VB denotes made
T14861 32505-32507 TO denotes to
T14862 32508-32518 VB denotes ameliorate
T14863 32519-32528 NN denotes suffering
T14864 32529-32531 IN denotes of
T14865 32532-32539 NN denotes animals
T14866 32541-32545 NN denotes Mice
T14867 32546-32550 VB denotes were
T14868 32551-32563 VB denotes anesthetized
T14869 32564-32566 IN denotes by
T14870 32567-32582 JJ denotes intraperitoneal
T14871 32583-32584 -LRB- denotes (
T14872 32584-32588 JJ denotes i.p.
T14873 32588-32589 -RRB- denotes )
T14874 32590-32599 NN denotes injection
T14875 32600-32602 IN denotes of
T14876 32603-32604 DT denotes a
T14877 32605-32612 NN denotes mixture
T14878 32613-32615 IN denotes of
T14879 32616-32624 NN denotes ketamine
T14880 32625-32626 -LRB- denotes (
T14881 32626-32628 CD denotes 12
T14882 32629-32634 NN denotes mg/kg
T14883 32634-32635 -RRB- denotes )
T14884 32636-32639 CC denotes and
T14885 32640-32648 NN denotes xylazine
T14886 32649-32650 -LRB- denotes (
T14887 32650-32652 CD denotes 60
T14888 32653-32658 NN denotes mg/kg
T14889 32658-32659 -RRB- denotes )
T15000 32662-32666 NN denotes Mice
T15001 32667-32675 NN denotes A20fl/fl
T15002 32676-32680 NN denotes mice
T15003 32681-32685 VB denotes were
T15004 32686-32695 VB denotes generated
T15005 32696-32698 IN denotes as
T15006 32699-32709 RB denotes previously
T15007 32710-32719 VB denotes described
T15008 32720-32721 -LRB- denotes [
T15009 32721-32723 CD denotes 56
T15010 32723-32724 -RRB- denotes ]
T15011 32726-32734 NN denotes A20fl/fl
T15012 32735-32739 NN denotes mice
T15013 32740-32744 VB denotes were
T15014 32745-32752 VB denotes crossed
T15015 32753-32757 IN denotes with
T15016 32758-32766 JJ denotes LysM-Cre
T15017 32767-32771 NN denotes mice
T15018 32772-32773 -LRB- denotes [
T15019 32773-32775 CD denotes 84
T15020 32775-32776 -RRB- denotes ]
T15021 32777-32778 -LRB- denotes (
T15022 32778-32786 VB denotes provided
T15023 32787-32789 IN denotes by
T15024 32790-32792 NNP denotes I.
T15025 32793-32800 NNP denotes Förster
T15026 32800-32801 -COMMA- denotes ,
T15027 32802-32811 NNP denotes Institute
T15028 32812-32814 IN denotes of
T15029 32815-32823 NNP denotes Genetics
T15030 32823-32824 -COMMA- denotes ,
T15031 32825-32835 NNP denotes University
T15032 32836-32838 IN denotes of
T15033 32839-32846 NNP denotes Cologne
T15034 32846-32847 -COMMA- denotes ,
T15035 32848-32855 NNP denotes Germany
T15036 32855-32856 -RRB- denotes )
T15037 32857-32859 TO denotes to
T15038 32860-32868 VB denotes generate
T15039 32869-32877 NN denotes A20fl/fl
T15040 32878-32885 NN denotes LysMCre
T15041 32886-32896 NN denotes transgenes
T15042 32897-32900 CC denotes and
T15043 32901-32904 VB denotes are
T15044 32905-32914 VB denotes described
T15045 32915-32917 IN denotes in
T15046 32918-32924 NN denotes detail
T15047 32925-32934 RB denotes elsewhere
T15048 32935-32936 -LRB- denotes [
T15049 32936-32938 CD denotes 48
T15050 32938-32939 -RRB- denotes ]
T15051 32941-32945 NN denotes Mice
T15052 32946-32950 VB denotes were
T15053 32951-32957 VB denotes housed
T15054 32958-32960 IN denotes in
T15055 32961-32973 RB denotes individually
T15056 32974-32984 VB denotes ventilated
T15057 32985-32990 NN denotes cages
T15058 32991-32993 IN denotes at
T15059 32994-32997 DT denotes the
T15060 32998-33001 NNP denotes VIB
T15061 33002-33012 NNP denotes Department
T15062 33013-33015 IN denotes of
T15063 33016-33025 NNP denotes Molecular
T15064 33026-33036 NNP denotes Biomedical
T15065 33037-33045 NNP denotes Research
T15066 33046-33048 IN denotes in
T15067 33049-33057 JJ denotes specific
T15068 33058-33071 JJ denotes pathogen-free
T15069 33072-33078 NN denotes animal
T15070 33079-33089 NN denotes facilities
T15071 33091-33100 NNP denotes Influenza
T15072 33101-33111 NN denotes infections
T15073 33112-33116 VB denotes were
T15074 33117-33126 VB denotes performed
T15075 33127-33129 IN denotes on
T15076 33130-33134 NN denotes age-
T15077 33135-33136 -LRB- denotes (
T15078 33136-33143 IN denotes between
T15079 33144-33145 CD denotes 7
T15080 33146-33149 CC denotes and
T15081 33150-33151 CD denotes 9
T15082 33152-33157 NN denotes weeks
T15083 33158-33161 JJ denotes old
T15084 33161-33162 -RRB- denotes )
T15085 33163-33166 CC denotes and
T15086 33167-33178 JJ denotes sex-matched
T15087 33179-33190 NN denotes littermates
T15088 33192-33200 NN denotes A20fl/fl
T15089 33201-33209 NN denotes LysM-Cre
T15090 33210-33217 NN denotes animals
T15091 33218-33222 VB denotes were
T15092 33223-33234 VB denotes backcrossed
T15093 33235-33240 CD denotes three
T15094 33241-33246 NN denotes times
T15095 33247-33249 TO denotes to
T15096 33250-33253 DT denotes the
T15097 33254-33261 NN denotes C57Bl/6
T15098 33262-33272 NN denotes background
T15099 33274-33282 NN denotes A20fl/fl
T15100 33283-33287 NN denotes mice
T15101 33288-33298 VB denotes expressing
T15102 33299-33301 CC denotes or
T15103 33302-33309 VB denotes lacking
T15104 33310-33313 DT denotes the
T15105 33314-33322 NN denotes LysM-Cre
T15106 33323-33332 NN denotes transgene
T15107 33333-33337 VB denotes were
T15108 33338-33344 VB denotes termed
T15109 33345-33355 NN denotes A20myel-KO
T15110 33356-33359 CC denotes and
T15111 33360-33364 JJ denotes wild
T15112 33365-33369 NN denotes type
T15113 33370-33371 -LRB- denotes (
T15114 33371-33381 NN denotes A20myel-WT
T15115 33381-33382 -RRB- denotes )
T15116 33383-33395 RB denotes respectively
T15295 33398-33403 JJ denotes Viral
T15296 33404-33413 NN denotes infection
T15297 33414-33417 CC denotes and
T15298 33418-33431 NN denotes determination
T15299 33432-33434 IN denotes of
T15300 33435-33440 JJ denotes viral
T15301 33441-33447 NN denotes titers
T15302 33448-33453 NN denotes Mouse
T15303 33454-33461 VB denotes adapted
T15304 33462-33465 NN denotes IAV
T15305 33466-33470 NN denotes X-47
T15306 33471-33472 -LRB- denotes (
T15307 33472-33476 NN denotes H3N2
T15308 33476-33477 -COLON- denotes ;
T15309 33478-33497 NN denotes PR8×A/Victoria/3/75
T15310 33497-33498 -RRB- denotes )
T15311 33499-33502 VB denotes was
T15312 33503-33513 VB denotes propagated
T15313 33514-33516 IN denotes in
T15314 33517-33521 NN denotes MDCK
T15315 33522-33527 NN denotes cells
T15316 33529-33532 IN denotes For
T15317 33533-33538 JJ denotes viral
T15318 33539-33550 NN denotes inoculation
T15319 33550-33551 -COMMA- denotes ,
T15320 33552-33556 NN denotes mice
T15321 33557-33561 VB denotes were
T15322 33562-33574 VB denotes anesthetized
T15323 33575-33577 IN denotes by
T15324 33578-33582 JJ denotes i.p.
T15325 33583-33592 NN denotes injection
T15326 33593-33597 IN denotes with
T15327 33598-33606 NN denotes ketamine
T15328 33607-33608 -LRB- denotes (
T15329 33608-33610 CD denotes 12
T15330 33611-33616 NN denotes mg/kg
T15331 33616-33617 -RRB- denotes )
T15332 33618-33621 CC denotes and
T15333 33622-33630 NN denotes xylazine
T15334 33631-33632 -LRB- denotes (
T15335 33632-33634 CD denotes 60
T15336 33635-33640 NN denotes mg/kg
T15337 33640-33641 -RRB- denotes )
T15338 33642-33645 CC denotes and
T15339 33646-33648 CD denotes 50
T15340 33649-33651 NN denotes µl
T15341 33652-33656 NN denotes X-47
T15342 33657-33664 VB denotes diluted
T15343 33665-33667 IN denotes in
T15344 33668-33671 NNP denotes PBS
T15345 33672-33675 VB denotes was
T15346 33676-33688 VB denotes administered
T15347 33689-33701 RB denotes intranasally
T15348 33703-33706 IN denotes For
T15349 33707-33713 JJ denotes lethal
T15350 33714-33717 CC denotes and
T15351 33718-33727 JJ denotes sublethal
T15352 33728-33737 NN denotes infection
T15353 33737-33738 -COMMA- denotes ,
T15354 33739-33743 NN denotes mice
T15355 33744-33752 VB denotes received
T15356 33753-33765 RB denotes respectively
T15357 33766-33772 NN denotes 2-LD50
T15358 33773-33775 CC denotes or
T15359 33776-33785 CD denotes 0.05-LD50
T15360 33786-33790 NN denotes X-47
T15361 33792-33794 TO denotes To
T15362 33795-33804 VB denotes determine
T15363 33805-33814 JJ denotes pulmonary
T15364 33815-33820 JJ denotes viral
T15365 33821-33827 NN denotes titers
T15366 33827-33828 -COMMA- denotes ,
T15367 33829-33835 JJ denotes median
T15368 33836-33842 NN denotes tissue
T15369 33843-33850 NN denotes culture
T15370 33851-33861 JJ denotes infectious
T15371 33862-33866 NN denotes dose
T15372 33867-33868 -LRB- denotes (
T15373 33868-33874 NN denotes TCID50
T15374 33874-33875 -RRB- denotes )
T15375 33876-33879 VB denotes was
T15376 33880-33888 VB denotes measured
T15377 33889-33891 IN denotes as
T15378 33892-33899 VB denotes follows
T15379 33899-33900 -COLON- denotes :
T15380 33901-33906 NN denotes lungs
T15381 33907-33911 VB denotes were
T15382 33912-33923 VB denotes homogenized
T15383 33924-33928 IN denotes with
T15384 33929-33930 DT denotes a
T15385 33931-33939 NN denotes Polytron
T15386 33940-33951 NN denotes homogenizer
T15387 33952-33953 -LRB- denotes (
T15388 33953-33963 NN denotes Kinematica
T15389 33963-33964 -RRB- denotes )
T15390 33965-33967 IN denotes in
T15391 33968-33971 NNP denotes PBS
T15392 33973-33983 JJ denotes Eight-fold
T15393 33984-33990 JJ denotes serial
T15394 33991-34000 NN denotes dilutions
T15395 34001-34003 IN denotes of
T15396 34004-34008 NN denotes lung
T15397 34009-34020 NN denotes homogenates
T15398 34021-34025 VB denotes were
T15399 34026-34035 VB denotes incubated
T15400 34036-34038 IN denotes on
T15401 34039-34043 NN denotes MDCK
T15402 34044-34049 NN denotes cells
T15403 34050-34053 IN denotes for
T15404 34054-34055 CD denotes 5
T15405 34056-34060 NN denotes days
T15406 34061-34063 IN denotes in
T15407 34064-34068 NN denotes DMEM
T15408 34069-34081 VB denotes supplemented
T15409 34082-34086 IN denotes with
T15410 34087-34094 NN denotes trypsin
T15411 34095-34096 -LRB- denotes (
T15412 34096-34097 CD denotes 1
T15413 34098-34103 NN denotes µg/ml
T15414 34103-34104 -RRB- denotes )
T15415 34104-34105 -COMMA- denotes ,
T15416 34106-34107 CD denotes 2
T15417 34108-34110 NN denotes mM
T15418 34111-34122 NN denotes L-glutamine
T15419 34122-34123 -COMMA- denotes ,
T15420 34124-34127 CD denotes 0.4
T15421 34128-34130 NN denotes mM
T15422 34131-34137 NN denotes sodium
T15423 34138-34146 NN denotes pyruvate
T15424 34147-34150 CC denotes and
T15425 34151-34162 NN denotes antibiotics
T15426 34164-34167 IN denotes For
T15427 34168-34176 NN denotes read-out
T15428 34176-34177 -COMMA- denotes ,
T15429 34178-34181 CD denotes 0.5
T15430 34181-34182 NN denotes %
T15431 34183-34190 NN denotes chicken
T15432 34191-34194 JJ denotes red
T15433 34195-34200 NN denotes blood
T15434 34201-34206 NN denotes cells
T15435 34207-34208 -LRB- denotes (
T15436 34208-34211 NN denotes RBC
T15437 34211-34212 -RRB- denotes )
T15438 34213-34217 VB denotes were
T15439 34218-34223 VB denotes added
T15440 34224-34227 CC denotes and
T15441 34228-34237 JJ denotes end-point
T15442 34238-34246 NN denotes dilution
T15443 34247-34249 IN denotes of
T15444 34250-34266 NN denotes hemagglutination
T15445 34267-34270 VB denotes was
T15446 34271-34280 VB denotes monitored
T15447 34282-34288 NN denotes TCID50
T15448 34289-34295 NN denotes titers
T15449 34296-34300 VB denotes were
T15450 34301-34305 RB denotes then
T15451 34306-34316 VB denotes calculated
T15452 34317-34326 VB denotes according
T15453 34327-34329 TO denotes to
T15454 34330-34333 DT denotes the
T15455 34334-34340 NN denotes method
T15456 34341-34343 IN denotes of
T15457 34344-34348 NNP denotes Reed
T15458 34349-34352 CC denotes and
T15459 34353-34359 NNP denotes Muench
T15460 34360-34361 -LRB- denotes [
T15461 34361-34363 CD denotes 85
T15462 34363-34364 -RRB- denotes ]
T15676 34367-34380 NN denotes Determination
T15677 34381-34383 IN denotes of
T15678 34384-34387 NN denotes HAI
T15679 34388-34389 -LRB- denotes (
T15680 34389-34405 NN denotes hemagglutination
T15681 34406-34416 NN denotes inhibition
T15682 34416-34417 -RRB- denotes )
T15683 34418-34424 NN denotes titers
T15684 34425-34427 TO denotes To
T15685 34428-34437 VB denotes determine
T15686 34438-34441 DT denotes the
T15687 34442-34445 NN denotes HAI
T15688 34446-34452 NN denotes titers
T15689 34453-34455 IN denotes in
T15690 34456-34464 JJ denotes infected
T15691 34465-34469 NN denotes mice
T15692 34469-34470 -COMMA- denotes ,
T15693 34471-34475 NN denotes sera
T15694 34476-34478 IN denotes of
T15695 34479-34484 DT denotes these
T15696 34485-34489 VB denotes were
T15697 34490-34497 VB denotes treated
T15698 34498-34502 IN denotes with
T15699 34503-34522 JJ denotes receptor-destroying
T15700 34523-34529 NN denotes enzyme
T15701 34530-34531 -LRB- denotes (
T15702 34531-34542 NN denotes RDE/Cholera
T15703 34543-34551 NN denotes filtrate
T15704 34551-34552 -COLON- denotes ;
T15705 34553-34558 NNP denotes Sigma
T15706 34558-34559 -RRB- denotes )
T15707 34560-34562 TO denotes to
T15708 34563-34569 VB denotes remove
T15709 34570-34576 JJ denotes sialic
T15710 34577-34582 NN denotes acids
T15711 34583-34587 IN denotes from
T15712 34588-34593 NN denotes serum
T15713 34594-34602 NN denotes proteins
T15714 34603-34610 JJ denotes capable
T15715 34611-34613 IN denotes of
T15716 34614-34623 JJ denotes aspecific
T15717 34624-34634 NN denotes inhibition
T15718 34635-34637 IN denotes of
T15719 34638-34651 NN denotes agglutination
T15720 34653-34658 IN denotes After
T15721 34659-34669 NN denotes incubation
T15722 34670-34679 RB denotes overnight
T15723 34680-34682 IN denotes at
T15724 34683-34687 NN denotes 37°C
T15725 34687-34688 -COMMA- denotes ,
T15726 34689-34692 DT denotes the
T15727 34693-34696 NN denotes RDE
T15728 34697-34700 VB denotes was
T15729 34701-34712 VB denotes inactivated
T15730 34713-34715 IN denotes by
T15731 34716-34724 NN denotes addition
T15732 34725-34727 IN denotes of
T15733 34728-34732 CD denotes 0.75
T15734 34732-34733 NN denotes %
T15735 34734-34740 NN denotes sodium
T15736 34741-34748 NN denotes citrate
T15737 34749-34751 IN denotes in
T15738 34752-34755 NNP denotes PBS
T15739 34756-34759 CC denotes and
T15740 34760-34767 NN denotes heating
T15741 34768-34770 TO denotes to
T15742 34771-34775 NN denotes 56°C
T15743 34776-34779 IN denotes for
T15744 34780-34782 CD denotes 30
T15745 34783-34786 NN denotes min
T15746 34788-34790 TO denotes To
T15747 34791-34797 VB denotes remove
T15748 34798-34804 JJ denotes sialic
T15749 34805-34809 NN denotes acid
T15750 34810-34817 NN denotes binding
T15751 34818-34826 NN denotes proteins
T15752 34826-34827 -COMMA- denotes ,
T15753 34828-34832 NN denotes sera
T15754 34833-34837 VB denotes were
T15755 34838-34845 VB denotes cleared
T15756 34846-34850 IN denotes with
T15757 34851-34855 CD denotes 1/10
T15758 34856-34862 NN denotes volume
T15759 34863-34865 CD denotes 50
T15760 34865-34866 NN denotes %
T15761 34867-34874 NN denotes chicken
T15762 34875-34878 NN denotes RBC
T15763 34880-34889 NN denotes Titration
T15764 34890-34893 VB denotes was
T15765 34894-34898 VB denotes done
T15766 34899-34901 IN denotes by
T15767 34902-34912 VB denotes incubating
T15768 34913-34914 DT denotes a
T15769 34915-34923 JJ denotes two-fold
T15770 34924-34932 NN denotes dilution
T15771 34933-34939 NN denotes series
T15772 34940-34942 IN denotes of
T15773 34943-34947 NN denotes sera
T15774 34948-34952 IN denotes with
T15775 34953-34954 CD denotes 4
T15776 34955-34957 NN denotes HA
T15777 34958-34963 NN denotes units
T15778 34964-34966 IN denotes of
T15779 34967-34971 NN denotes X-47
T15780 34972-34977 NN denotes virus
T15781 34978-34981 IN denotes for
T15782 34982-34983 CD denotes 1
T15783 34984-34988 NN denotes hour
T15784 34989-34991 IN denotes at
T15785 34992-34996 NN denotes room
T15786 34997-35008 NN denotes temperature
T15787 35009-35011 IN denotes in
T15788 35012-35019 JJ denotes 96-well
T15789 35020-35028 NN denotes U-bottom
T15790 35029-35035 NN denotes plates
T15791 35037-35044 RB denotes Finally
T15792 35044-35045 -COMMA- denotes ,
T15793 35046-35048 DT denotes an
T15794 35049-35054 JJ denotes equal
T15795 35055-35061 NN denotes volume
T15796 35062-35064 IN denotes of
T15797 35065-35068 CD denotes 0.5
T15798 35068-35069 NN denotes %
T15799 35070-35077 NN denotes chicken
T15800 35078-35081 NN denotes RBC
T15801 35082-35085 VB denotes was
T15802 35086-35091 VB denotes added
T15803 35092-35095 CC denotes and
T15804 35096-35102 NN denotes titers
T15805 35103-35107 VB denotes were
T15806 35108-35112 VB denotes read
T15807 35113-35115 CD denotes 30
T15808 35116-35119 NN denotes min
T15809 35120-35125 RB denotes later
T15810 35127-35135 JJ denotes Negative
T15811 35136-35144 NN denotes controls
T15812 35145-35153 VB denotes included
T15813 35154-35157 NNP denotes PBS
T15814 35158-35165 RB denotes instead
T15815 35166-35168 IN denotes of
T15816 35169-35175 JJ denotes immune
T15817 35176-35181 NN denotes serum
T15818 35182-35183 -LRB- denotes (
T15819 35183-35196 NN denotes agglutination
T15820 35197-35204 NN denotes control
T15821 35204-35205 -RRB- denotes )
T15822 35206-35208 CC denotes or
T15823 35209-35212 NN denotes PR8
T15824 35213-35220 RB denotes instead
T15825 35221-35223 IN denotes of
T15826 35224-35228 NN denotes X-47
T15827 35229-35234 NN denotes virus
T15828 35235-35236 -LRB- denotes (
T15829 35236-35243 NN denotes control
T15830 35244-35247 IN denotes for
T15831 35248-35261 NN denotes agglutination
T15832 35262-35268 NN denotes effect
T15833 35269-35271 IN denotes of
T15834 35272-35276 NN denotes sera
T15835 35276-35277 -RRB- denotes )
T15836 35277-35278 -COLON- denotes ;
T15837 35279-35281 IN denotes as
T15838 35282-35290 JJ denotes positive
T15839 35291-35298 NN denotes control
T15840 35298-35299 -COMMA- denotes ,
T15841 35300-35305 NN denotes serum
T15842 35306-35310 IN denotes from
T15843 35311-35312 DT denotes a
T15844 35313-35318 NN denotes mouse
T15845 35319-35327 VB denotes infected
T15846 35328-35333 RB denotes twice
T15847 35334-35338 IN denotes with
T15848 35339-35340 DT denotes a
T15849 35341-35350 JJ denotes sublethal
T15850 35351-35355 NN denotes dose
T15851 35356-35358 IN denotes of
T15852 35359-35363 NN denotes X-47
T15853 35364-35367 VB denotes was
T15854 35368-35372 VB denotes used
T16146 35375-35377 FW denotes In
T16147 35378-35382 FW denotes vivo
T16148 35383-35396 JJ denotes intracellular
T16149 35397-35400 NN denotes GrB
T16150 35401-35404 CC denotes and
T16151 35405-35409 NN denotes IFNγ
T16152 35410-35418 NN denotes staining
T16153 35419-35421 IN denotes of
T16154 35422-35431 VB denotes activated
T16155 35432-35436 JJ denotes CD8+
T16156 35437-35438 NN denotes T
T16157 35439-35444 NN denotes cells
T16158 35445-35453 NN denotes Granzyme
T16159 35454-35455 NN denotes B
T16160 35456-35457 -LRB- denotes (
T16161 35457-35460 NN denotes GrB
T16162 35460-35461 -RRB- denotes )
T16163 35462-35465 CC denotes and
T16164 35466-35470 NN denotes IFNγ
T16165 35471-35481 VB denotes expressing
T16166 35482-35486 JJ denotes CD8+
T16167 35487-35488 NN denotes T
T16168 35489-35494 NN denotes cells
T16169 35495-35499 VB denotes were
T16170 35500-35510 VB denotes determined
T16171 35511-35513 IN denotes by
T16172 35514-35522 VB denotes treating
T16173 35523-35526 DT denotes the
T16174 35527-35531 NN denotes mice
T16175 35532-35544 RB denotes intranasally
T16176 35545-35549 IN denotes with
T16177 35550-35552 CD denotes 50
T16178 35553-35555 NN denotes µg
T16179 35556-35565 NN denotes Brefeldin
T16180 35566-35567 NN denotes A
T16181 35568-35569 -LRB- denotes (
T16182 35569-35574 NN denotes Sigma
T16183 35574-35575 -RRB- denotes )
T16184 35576-35578 IN denotes as
T16185 35579-35589 RB denotes previously
T16186 35590-35599 VB denotes described
T16187 35600-35601 -LRB- denotes [
T16188 35601-35603 CD denotes 86
T16189 35603-35604 -RRB- denotes ]
T16190 35606-35607 CD denotes 6
T16191 35608-35609 NN denotes h
T16192 35610-35615 RB denotes later
T16193 35615-35616 -COMMA- denotes ,
T16194 35617-35620 NN denotes BAL
T16195 35621-35624 CC denotes and
T16196 35625-35630 NN denotes lungs
T16197 35631-35635 VB denotes were
T16198 35636-35644 VB denotes isolated
T16199 35645-35648 CC denotes and
T16200 35649-35655 JJ denotes single
T16201 35656-35660 NN denotes cell
T16202 35661-35672 NN denotes suspensions
T16203 35673-35677 VB denotes were
T16204 35678-35686 VB denotes prepared
T16205 35687-35691 IN denotes from
T16206 35692-35695 DT denotes the
T16207 35696-35700 NN denotes lung
T16208 35701-35703 IN denotes in
T16209 35704-35707 DT denotes the
T16210 35708-35716 NN denotes presence
T16211 35717-35719 IN denotes of
T16212 35720-35721 CD denotes 3
T16213 35722-35727 NN denotes µg/ml
T16214 35728-35737 NNP denotes Brefeldin
T16215 35738-35740 NN denotes A.
T16216 35741-35746 NNP denotes Cells
T16217 35747-35751 VB denotes were
T16218 35752-35759 VB denotes stained
T16219 35759-35760 -COMMA- denotes ,
T16220 35761-35766 VB denotes fixed
T16221 35767-35770 CC denotes and
T16222 35771-35784 VB denotes permeabilized
T16223 35785-35786 -LRB- denotes (
T16224 35786-35802 NN denotes Cytofix/Cytoperm
T16225 35802-35803 -COMMA- denotes ,
T16226 35804-35806 NNP denotes BD
T16227 35807-35818 NNP denotes Biosciences
T16228 35818-35819 -RRB- denotes )
T16229 35820-35829 VB denotes according
T16230 35830-35832 TO denotes to
T16231 35833-35836 DT denotes the
T16232 35837-35849 NN denotes manufacturer
T16233 35849-35851 POS denotes 's
T16234 35852-35864 NN denotes instructions
T16235 35866-35875 VB denotes Activated
T16236 35876-35880 JJ denotes CD8+
T16237 35881-35882 NN denotes T
T16238 35883-35888 NN denotes cells
T16239 35889-35893 VB denotes were
T16240 35894-35902 VB denotes analyzed
T16241 35903-35905 IN denotes by
T16242 35906-35910 NN denotes flow
T16243 35911-35920 NN denotes cytometry
T16244 35921-35926 VB denotes based
T16245 35927-35929 IN denotes on
T16246 35930-35936 JJ denotes CD62lo
T16247 35937-35941 JJ denotes CD3+
T16248 35942-35945 CC denotes and
T16249 35946-35950 JJ denotes CD8+
T16250 35951-35961 NN denotes expression
T16251 35963-35972 JJ denotes Live/Dead
T16252 35973-35980 JJ denotes fixable
T16253 35981-35985 NN denotes aqua
T16254 35986-35990 JJ denotes dead
T16255 35991-35995 NN denotes cell
T16256 35996-36001 NN denotes stain
T16257 36002-36005 NN denotes kit
T16258 36006-36007 -LRB- denotes (
T16259 36007-36016 NNP denotes Molecular
T16260 36017-36023 NNP denotes Probes
T16261 36023-36024 -RRB- denotes )
T16262 36025-36028 VB denotes was
T16263 36029-36033 VB denotes used
T16264 36034-36036 TO denotes to
T16265 36037-36049 VB denotes discriminate
T16266 36050-36054 JJ denotes live
T16267 36055-36059 IN denotes from
T16268 36060-36064 JJ denotes dead
T16269 36065-36070 NN denotes cells
T16567 36073-36078 NN denotes Cells
T16568 36079-36082 CC denotes and
T16569 36083-36095 NN denotes transfection
T16570 36096-36103 NN denotes HEK293T
T16571 36104-36107 CC denotes and
T16572 36108-36112 NN denotes MDCK
T16573 36113-36118 NN denotes cells
T16574 36119-36123 VB denotes were
T16575 36124-36129 VB denotes grown
T16576 36130-36132 IN denotes in
T16577 36133-36137 NN denotes DMEM
T16578 36138-36139 -LRB- denotes (
T16579 36139-36144 NN denotes Gibco
T16580 36144-36145 -RRB- denotes )
T16581 36146-36158 VB denotes supplemented
T16582 36159-36163 IN denotes with
T16583 36164-36166 CD denotes 10
T16584 36166-36167 NN denotes %
T16585 36168-36171 NN denotes FCS
T16586 36171-36172 -COMMA- denotes ,
T16587 36173-36174 CD denotes 2
T16588 36175-36177 NN denotes mM
T16589 36178-36189 NN denotes L-glutamine
T16590 36189-36190 -COMMA- denotes ,
T16591 36191-36194 CD denotes 0.4
T16592 36195-36197 NN denotes mM
T16593 36198-36204 NN denotes sodium
T16594 36205-36213 NN denotes pyruvate
T16595 36214-36217 CC denotes and
T16596 36218-36229 NN denotes antibiotics
T16597 36231-36238 NN denotes HEK293T
T16598 36239-36244 NN denotes cells
T16599 36245-36249 VB denotes were
T16600 36250-36261 VB denotes transfected
T16601 36262-36267 VB denotes using
T16602 36268-36271 DT denotes the
T16603 36272-36279 NN denotes calcium
T16604 36280-36289 NN denotes phosphate
T16605 36290-36301 VB denotes precipitate
T16606 36302-36314 NN denotes transfection
T16607 36315-36321 NN denotes method
T16608 36322-36326 IN denotes with
T16609 36327-36335 JJ denotes specific
T16610 36336-36346 NN denotes expression
T16611 36347-36354 NN denotes vectors
T16612 36355-36356 -LRB- denotes (
T16613 36356-36369 NN denotes pCAGGS-E-hA20
T16614 36370-36371 -LRB- denotes (
T16615 36371-36375 NN denotes LMBP
T16616 36376-36380 CD denotes 3778
T16617 36380-36381 -RRB- denotes )
T16618 36381-36382 -COMMA- denotes ,
T16619 36383-36402 NN denotes pCAGGS-E-RIG-I-CARD
T16620 36403-36404 -LRB- denotes (
T16621 36404-36408 NN denotes LMBP
T16622 36409-36413 CD denotes 6517
T16623 36413-36414 -RRB- denotes )
T16624 36414-36415 -COMMA- denotes ,
T16625 36416-36428 NN denotes pEF-HA-IRF-7
T16626 36429-36430 -LRB- denotes (
T16627 36430-36436 RB denotes kindly
T16628 36437-36445 VB denotes provided
T16629 36446-36448 IN denotes by
T16630 36449-36451 NNP denotes T.
T16631 36452-36461 NNP denotes Taniguchi
T16632 36461-36462 -COMMA- denotes ,
T16633 36463-36471 NNP denotes Graduate
T16634 36472-36478 NNP denotes School
T16635 36479-36481 IN denotes of
T16636 36482-36490 NNP denotes Medicine
T16637 36491-36494 CC denotes and
T16638 36495-36502 NNP denotes Faculty
T16639 36503-36505 IN denotes of
T16640 36506-36514 NNP denotes Medicine
T16641 36514-36515 -COMMA- denotes ,
T16642 36516-36526 NNP denotes University
T16643 36527-36529 IN denotes of
T16644 36530-36535 NNP denotes Tokyo
T16645 36535-36536 -RRB- denotes )
T16646 36536-36537 -RRB- denotes )
T16647 36537-36538 -COMMA- denotes ,
T16648 36539-36544 NN denotes NF-κB
T16649 36544-36545 -COMMA- denotes ,
T16650 36546-36550 NN denotes IRF3
T16651 36550-36551 -COMMA- denotes ,
T16652 36552-36556 NN denotes IRF7
T16653 36557-36565 NN denotes reporter
T16654 36566-36574 NN denotes plasmids
T16655 36575-36576 -LRB- denotes (
T16656 36576-36588 RB denotes respectively
T16657 36589-36596 NN denotes pConLuc
T16658 36597-36598 -LRB- denotes (
T16659 36598-36606 NN denotes LMBP3248
T16660 36606-36607 -RRB- denotes )
T16661 36607-36608 -COMMA- denotes ,
T16662 36609-36618 NN denotes pISRE-luc
T16663 36619-36620 -LRB- denotes (
T16664 36620-36628 NN denotes LMBP4011
T16665 36628-36629 -RRB- denotes )
T16666 36629-36630 -COMMA- denotes ,
T16667 36631-36645 NN denotes pGL3-IFNα4-luc
T16668 36646-36647 -LRB- denotes (
T16669 36647-36653 RB denotes kindly
T16670 36654-36662 VB denotes provided
T16671 36663-36665 IN denotes by
T16672 36666-36668 NNP denotes J.
T16673 36669-36676 NNP denotes Hiscott
T16674 36676-36677 -COMMA- denotes ,
T16675 36678-36684 NNP denotes McGill
T16676 36685-36695 NNP denotes University
T16677 36695-36696 -COMMA- denotes ,
T16678 36697-36705 NNP denotes Montreal
T16679 36705-36706 -COMMA- denotes ,
T16680 36707-36713 NNP denotes Quebec
T16681 36713-36714 -COMMA- denotes ,
T16682 36715-36721 NNP denotes Canada
T16683 36721-36722 -RRB- denotes )
T16684 36722-36723 -COMMA- denotes ,
T16685 36724-36727 CC denotes and
T16686 36728-36739 NN denotes pACTbetagal
T16687 36740-36741 -LRB- denotes (
T16688 36741-36749 NN denotes LMBP4341
T16689 36749-36750 -RRB- denotes )
T16690 36751-36754 IN denotes for
T16691 36755-36767 NN denotes transfection
T16692 36768-36778 NN denotes efficiency
T16693 36779-36792 NN denotes normalization
T16694 36794-36801 NN denotes Details
T16695 36802-36804 IN denotes of
T16696 36805-36813 NN denotes plasmids
T16697 36814-36817 VB denotes are
T16698 36818-36827 VB denotes presented
T16699 36828-36833 IN denotes along
T16700 36834-36838 IN denotes with
T16701 36839-36847 JJ denotes detailed
T16702 36848-36856 NN denotes sequence
T16703 36857-36861 NN denotes maps
T16704 36862-36864 IN denotes at
T16705 36865-36868 DT denotes the
T16706 36869-36878 NN denotes BCCM-LMBP
T16707 36879-36886 NN denotes plasmid
T16708 36887-36895 NN denotes databank
T16709 36896-36900 NN denotes http
T16710 36900-36901 -COLON- denotes :
T16711 36901-36927 VB denotes //bccm.belspo.be/index.php
T16712 36929-36932 IN denotes For
T16713 36933-36936 DT denotes the
T16714 36937-36947 NN denotes generation
T16715 36948-36950 IN denotes of
T16716 36951-36955 NN denotes BMDM
T16717 36955-36956 -COMMA- denotes ,
T16718 36957-36961 NN denotes bone
T16719 36962-36968 NN denotes marrow
T16720 36969-36974 NN denotes cells
T16721 36975-36979 VB denotes were
T16722 36980-36988 VB denotes cultured
T16723 36989-36990 CD denotes 7
T16724 36991-36995 NN denotes days
T16725 36996-36998 IN denotes in
T16726 36999-37003 NN denotes RPMI
T16727 37004-37008 CD denotes 1640
T16728 37009-37010 -LRB- denotes (
T16729 37010-37015 NNP denotes Gibco
T16730 37015-37016 -RRB- denotes )
T16731 37017-37029 VB denotes supplemented
T16732 37030-37034 IN denotes with
T16733 37035-37037 CD denotes 10
T16734 37037-37038 NN denotes %
T16735 37039-37042 NN denotes FCS
T16736 37042-37043 -COMMA- denotes ,
T16737 37044-37045 CD denotes 2
T16738 37046-37048 NN denotes mM
T16739 37049-37060 NN denotes L-glutamine
T16740 37060-37061 -COMMA- denotes ,
T16741 37062-37065 CD denotes 0.4
T16742 37066-37068 NN denotes mM
T16743 37069-37075 NN denotes sodium
T16744 37076-37084 NN denotes pyruvate
T16745 37084-37085 -COMMA- denotes ,
T16746 37086-37097 NN denotes antibiotics
T16747 37098-37101 CC denotes and
T16748 37102-37104 CD denotes 40
T16749 37105-37110 NN denotes ng/ml
T16750 37111-37122 JJ denotes recombinant
T16751 37123-37128 NN denotes M-CSF
T16752 37130-37134 NN denotes BMDM
T16753 37135-37139 VB denotes were
T16754 37140-37142 IN denotes of
T16755 37143-37146 CD denotes ≥95
T16756 37146-37147 NN denotes %
T16757 37148-37154 NN denotes purity
T16758 37155-37157 IN denotes as
T16759 37158-37166 VB denotes measured
T16760 37167-37169 IN denotes by
T16761 37170-37174 NN denotes flow
T16762 37175-37184 NN denotes cytometry
T16763 37185-37190 VB denotes using
T16764 37191-37196 NN denotes F4/80
T16765 37197-37200 CC denotes and
T16766 37201-37206 NN denotes CD11b
T16767 37207-37215 JJ denotes specific
T16768 37216-37226 NN denotes antibodies
T16769 37228-37231 IN denotes For
T16770 37232-37235 DT denotes the
T16771 37236-37245 NN denotes isolation
T16772 37246-37248 IN denotes of
T16773 37249-37257 JJ denotes alveolar
T16774 37258-37269 NN denotes macrophages
T16775 37269-37270 -COMMA- denotes ,
T16776 37271-37274 DT denotes the
T16777 37275-37282 NN denotes trachea
T16778 37283-37286 VB denotes was
T16779 37287-37296 VB denotes canulated
T16780 37297-37300 CC denotes and
T16781 37301-37304 DT denotes the
T16782 37305-37309 NN denotes lung
T16783 37310-37313 VB denotes was
T16784 37314-37321 VB denotes flushed
T16785 37322-37323 CD denotes 4
T16786 37324-37329 NN denotes times
T16787 37330-37334 IN denotes with
T16788 37335-37339 NN denotes HBSS
T16789 37340-37350 VB denotes containing
T16790 37351-37352 CD denotes 1
T16791 37353-37355 NN denotes mM
T16792 37356-37360 NN denotes EDTA
T16793 37362-37370 JJ denotes Alveolar
T16794 37371-37382 NN denotes macrophages
T16795 37383-37387 VB denotes were
T16796 37388-37396 VB denotes cultured
T16797 37397-37399 IN denotes in
T16798 37400-37404 NN denotes RPMI
T16799 37405-37409 CD denotes 1640
T16800 37410-37411 -LRB- denotes (
T16801 37411-37416 NNP denotes Gibco
T16802 37416-37417 -RRB- denotes )
T16803 37418-37430 VB denotes supplemented
T16804 37431-37435 IN denotes with
T16805 37436-37437 CD denotes 1
T16806 37437-37438 NN denotes %
T16807 37439-37442 NN denotes FCS
T16808 37442-37443 -COMMA- denotes ,
T16809 37444-37445 CD denotes 2
T16810 37446-37448 NN denotes mM
T16811 37449-37460 NN denotes L-glutamine
T16812 37460-37461 -COMMA- denotes ,
T16813 37462-37465 CD denotes 0.4
T16814 37466-37468 NN denotes mM
T16815 37469-37475 NN denotes sodium
T16816 37476-37484 NN denotes pyruvate
T16817 37485-37488 CC denotes and
T16818 37489-37500 NN denotes antibiotics
T17177 37503-37510 NN denotes Western
T17178 37511-37519 NN denotes blotting
T17179 37520-37523 IN denotes For
T17180 37524-37529 JJ denotes total
T17181 37530-37537 NN denotes lysates
T17182 37537-37538 -COMMA- denotes ,
T17183 37539-37544 NN denotes cells
T17184 37545-37549 VB denotes were
T17185 37550-37555 VB denotes lysed
T17186 37556-37558 IN denotes at
T17187 37559-37562 NN denotes 4°C
T17188 37563-37566 IN denotes for
T17189 37567-37569 CD denotes 15
T17190 37570-37573 NN denotes min
T17191 37574-37576 IN denotes in
T17192 37577-37582 NN denotes lysis
T17193 37583-37589 NN denotes buffer
T17194 37590-37591 -LRB- denotes (
T17195 37591-37594 CD denotes 200
T17196 37595-37597 NN denotes mM
T17197 37598-37602 NN denotes NaCl
T17198 37602-37603 -COMMA- denotes ,
T17199 37604-37605 CD denotes 1
T17200 37605-37606 NN denotes %
T17201 37607-37612 NN denotes NP-40
T17202 37612-37613 -COMMA- denotes ,
T17203 37614-37616 CD denotes 10
T17204 37617-37619 NN denotes mM
T17205 37620-37628 NN denotes Tris-HCl
T17206 37629-37631 NN denotes pH
T17207 37632-37635 CD denotes 7.5
T17208 37635-37636 -COMMA- denotes ,
T17209 37637-37638 CD denotes 5
T17210 37639-37641 NN denotes mM
T17211 37642-37646 NN denotes EDTA
T17212 37646-37647 -COMMA- denotes ,
T17213 37648-37649 CD denotes 2
T17214 37650-37652 NN denotes mM
T17215 37653-37656 NN denotes DTT
T17216 37656-37657 -RRB- denotes )
T17217 37658-37670 VB denotes supplemented
T17218 37671-37675 IN denotes with
T17219 37676-37684 NN denotes protease
T17220 37685-37688 CC denotes and
T17221 37689-37700 NN denotes phosphatase
T17222 37701-37711 NN denotes inhibitors
T17223 37713-37720 JJ denotes Nuclear
T17224 37721-37724 CC denotes and
T17225 37725-37736 JJ denotes cytoplasmic
T17226 37737-37744 NN denotes lysates
T17227 37745-37749 VB denotes were
T17228 37750-37758 VB denotes prepared
T17229 37759-37761 IN denotes by
T17230 37762-37774 VB denotes resuspending
T17231 37775-37780 NN denotes cells
T17232 37781-37783 IN denotes in
T17233 37784-37786 NN denotes B1
T17234 37787-37788 -LRB- denotes (
T17235 37788-37790 CD denotes 10
T17236 37791-37793 NN denotes mM
T17237 37794-37799 NNP denotes Hepes
T17238 37800-37802 NN denotes pH
T17239 37803-37806 CD denotes 7.5
T17240 37806-37807 -COMMA- denotes ,
T17241 37808-37810 CD denotes 10
T17242 37811-37813 NN denotes mM
T17243 37814-37817 NN denotes KCl
T17244 37817-37818 -COMMA- denotes ,
T17245 37819-37820 CD denotes 1
T17246 37821-37823 NN denotes mM
T17247 37824-37829 NN denotes MgCl2
T17248 37829-37830 -COMMA- denotes ,
T17249 37831-37832 CD denotes 5
T17250 37832-37833 NN denotes %
T17251 37834-37842 NN denotes glycerol
T17252 37842-37843 -COMMA- denotes ,
T17253 37844-37847 CD denotes 0.5
T17254 37848-37850 NN denotes mM
T17255 37851-37855 NN denotes EDTA
T17256 37856-37859 CC denotes and
T17257 37860-37863 CD denotes 0.1
T17258 37864-37866 NN denotes mM
T17259 37867-37871 NN denotes EGTA
T17260 37872-37884 VB denotes supplemented
T17261 37885-37889 IN denotes with
T17262 37890-37898 NN denotes protease
T17263 37899-37902 CC denotes and
T17264 37903-37914 NN denotes phosphatase
T17265 37915-37925 NN denotes inhibitors
T17266 37925-37926 -RRB- denotes )
T17267 37927-37930 IN denotes for
T17268 37931-37933 CD denotes 15
T17269 37934-37937 NN denotes min
T17270 37938-37940 IN denotes at
T17271 37941-37945 NNP denotes 4°C.
T17272 37946-37950 NNP denotes Next
T17273 37950-37951 -COMMA- denotes ,
T17274 37952-37957 NN denotes NP-40
T17275 37958-37967 NN denotes detergent
T17276 37968-37971 VB denotes was
T17277 37972-37977 VB denotes added
T17278 37978-37980 TO denotes to
T17279 37981-37982 DT denotes a
T17280 37983-37988 JJ denotes final
T17281 37989-38002 NN denotes concentration
T17282 38003-38005 IN denotes of
T17283 38006-38010 CD denotes 0.65
T17284 38010-38011 NN denotes %
T17285 38012-38015 CC denotes and
T17286 38016-38021 NN denotes cells
T17287 38022-38026 VB denotes were
T17288 38027-38038 VB denotes centrifuged
T17289 38039-38041 IN denotes at
T17290 38042-38045 CD denotes 500
T17291 38046-38047 NN denotes g
T17292 38048-38051 IN denotes for
T17293 38052-38053 CD denotes 5
T17294 38054-38057 NN denotes min
T17295 38059-38062 DT denotes The
T17296 38063-38070 JJ denotes nuclear
T17297 38071-38079 NN denotes fraction
T17298 38080-38090 VB denotes containing
T17299 38091-38097 NN denotes pellet
T17300 38098-38101 VB denotes was
T17301 38102-38107 VB denotes lyzed
T17302 38108-38110 IN denotes in
T17303 38111-38113 NN denotes B2
T17304 38114-38115 -LRB- denotes (
T17305 38115-38117 CD denotes 20
T17306 38118-38120 NN denotes mM
T17307 38121-38126 NNP denotes Hepes
T17308 38127-38129 NN denotes pH
T17309 38130-38133 CD denotes 7.5
T17310 38133-38134 -COMMA- denotes ,
T17311 38135-38136 CD denotes 1
T17312 38136-38137 NN denotes %
T17313 38138-38143 NN denotes NP-40
T17314 38143-38144 -COMMA- denotes ,
T17315 38145-38148 CD denotes 400
T17316 38149-38151 NN denotes mM
T17317 38152-38156 NN denotes NaCl
T17318 38156-38157 -COMMA- denotes ,
T17319 38158-38160 CD denotes 10
T17320 38161-38163 NN denotes mM
T17321 38164-38167 NN denotes KCl
T17322 38167-38168 -COMMA- denotes ,
T17323 38169-38170 CD denotes 1
T17324 38171-38173 NN denotes mM
T17325 38174-38179 NN denotes MgCl2
T17326 38179-38180 -COMMA- denotes ,
T17327 38181-38183 CD denotes 20
T17328 38183-38184 NN denotes %
T17329 38185-38193 NN denotes glycerol
T17330 38193-38194 -COMMA- denotes ,
T17331 38195-38198 CD denotes 0.5
T17332 38199-38201 NN denotes mM
T17333 38202-38206 NN denotes EDTA
T17334 38207-38210 CC denotes and
T17335 38211-38214 CD denotes 0.1
T17336 38215-38217 NN denotes mM
T17337 38218-38222 NN denotes EGTA
T17338 38223-38235 VB denotes supplemented
T17339 38236-38240 IN denotes with
T17340 38241-38249 NN denotes protease
T17341 38250-38253 CC denotes and
T17342 38254-38265 NN denotes phosphatase
T17343 38266-38276 NN denotes inhibitors
T17344 38276-38277 -RRB- denotes )
T17345 38278-38281 IN denotes for
T17346 38282-38284 CD denotes 15
T17347 38285-38288 NN denotes min
T17348 38289-38291 IN denotes at
T17349 38292-38296 NNP denotes 4°C.
T17350 38297-38300 DT denotes The
T17351 38301-38308 NN denotes lysates
T17352 38309-38313 VB denotes were
T17353 38314-38326 RB denotes subsequently
T17354 38327-38336 VB denotes separated
T17355 38337-38339 IN denotes by
T17356 38340-38348 NN denotes SDS-PAGE
T17357 38349-38352 CC denotes and
T17358 38353-38361 VB denotes analyzed
T17359 38362-38364 IN denotes by
T17360 38365-38372 JJ denotes western
T17361 38373-38381 NN denotes blotting
T17362 38382-38385 CC denotes and
T17363 38386-38389 NN denotes ECL
T17364 38390-38399 NN denotes detection
T17365 38400-38401 -LRB- denotes (
T17366 38401-38407 NNP denotes Perkin
T17367 38408-38413 NNP denotes Elmer
T17368 38414-38418 NNP denotes Life
T17369 38419-38427 NNP denotes Sciences
T17370 38427-38428 -RRB- denotes )
T17371 38430-38441 NN denotes Immunoblots
T17372 38442-38446 VB denotes were
T17373 38447-38455 VB denotes revealed
T17374 38456-38460 IN denotes with
T17375 38461-38469 JJ denotes anti-A20
T17376 38469-38470 -COMMA- denotes ,
T17377 38471-38480 JJ denotes anti-IκBα
T17378 38480-38481 -COMMA- denotes ,
T17379 38482-38490 JJ denotes anti-p65
T17380 38490-38491 -COMMA- denotes ,
T17381 38492-38495 CC denotes and
T17382 38496-38507 JJ denotes anti-histon
T17383 38508-38510 NN denotes H1
T17384 38511-38512 -LRB- denotes (
T17385 38512-38517 NNP denotes Santa
T17386 38518-38522 NNP denotes Cruz
T17387 38522-38523 -RRB- denotes )
T17388 38523-38524 -COMMA- denotes ,
T17389 38525-38534 NN denotes anti-IRF3
T17390 38535-38536 -LRB- denotes (
T17391 38536-38546 NN denotes Invitrogen
T17392 38546-38547 -RRB- denotes )
T17393 38547-38548 -COMMA- denotes ,
T17394 38549-38566 JJ denotes anti-phospho-IRF3
T17395 38567-38570 CC denotes and
T17396 38571-38588 JJ denotes anti-phospho-IκBα
T17397 38589-38590 -LRB- denotes (
T17398 38590-38594 NN denotes Cell
T17399 38595-38604 NN denotes Signaling
T17400 38604-38605 -RRB- denotes )
T17401 38606-38609 CC denotes and
T17402 38610-38620 JJ denotes anti-actin
T17403 38621-38622 -LRB- denotes (
T17404 38622-38624 NN denotes MP
T17405 38625-38636 NN denotes Biomedicals
T17406 38636-38637 -RRB- denotes )
T17407 38639-38642 DT denotes The
T17408 38643-38650 NN denotes density
T17409 38651-38653 IN denotes of
T17410 38654-38657 DT denotes the
T17411 38658-38663 NN denotes bands
T17412 38664-38667 VB denotes was
T17413 38668-38678 VB denotes quantified
T17414 38679-38680 -LRB- denotes (
T17415 38680-38684 JJ denotes fold
T17416 38685-38694 NN denotes induction
T17417 38694-38695 -RRB- denotes )
T17418 38696-38700 IN denotes with
T17419 38701-38704 DT denotes the
T17420 38705-38711 NN denotes ImageJ
T17421 38712-38713 -LRB- denotes (
T17422 38713-38717 NN denotes http
T17423 38717-38718 -COLON- denotes :
T17424 38718-38737 LS denotes //rsbweb.nih.gov/ij
T17425 38737-38738 -RRB- denotes )
T17426 38739-38742 NN denotes Gel
T17427 38743-38751 NN denotes analyzer
T17428 38752-38756 NN denotes tool
T17429 38758-38761 DT denotes All
T17430 38762-38773 NN denotes intensities
T17431 38774-38778 VB denotes were
T17432 38779-38789 VB denotes calculated
T17433 38790-38798 JJ denotes relative
T17434 38799-38801 TO denotes to
T17435 38802-38805 DT denotes the
T17436 38806-38811 JJ denotes first
T17437 38812-38816 NN denotes lane
T17438 38817-38818 -LRB- denotes (
T17439 38818-38825 RB denotes  = time
T17440 38826-38827 CD denotes 0
T17441 38827-38828 -RRB- denotes )
T17870 38831-38835 NN denotes Flow
T17871 38836-38845 NN denotes cytometry
T17872 38846-38851 NN denotes Lungs
T17873 38852-38856 VB denotes were
T17874 38857-38866 VB denotes dissected
T17875 38867-38870 CC denotes and
T17876 38871-38880 VB denotes incubated
T17877 38881-38885 IN denotes with
T17878 38886-38897 NN denotes collagenase
T17879 38898-38902 NN denotes type
T17880 38903-38905 CD denotes IV
T17881 38906-38907 -LRB- denotes (
T17882 38907-38908 CD denotes 1
T17883 38909-38914 NN denotes mg/ml
T17884 38914-38915 -COLON- denotes ;
T17885 38916-38921 NNP denotes Sigma
T17886 38921-38922 -RRB- denotes )
T17887 38923-38926 CC denotes and
T17888 38927-38932 NN denotes DNAse
T17889 38933-38934 -LRB- denotes (
T17890 38934-38937 CD denotes 100
T17891 38938-38942 NN denotes U/ml
T17892 38942-38943 -COLON- denotes ;
T17893 38944-38949 NNP denotes Roche
T17894 38949-38950 -RRB- denotes )
T17895 38951-38953 IN denotes at
T17896 38954-38958 NN denotes 37°C
T17897 38959-38962 IN denotes for
T17898 38963-38965 CD denotes 30
T17899 38966-38969 NN denotes min
T17900 38971-38983 RB denotes Subsequently
T17901 38983-38984 -COMMA- denotes ,
T17902 38985-38992 NN denotes samples
T17903 38993-38997 VB denotes were
T17904 38998-39006 VB denotes filtered
T17905 39007-39014 IN denotes through
T17906 39015-39016 DT denotes a
T17907 39017-39019 CD denotes 70
T17908 39020-39022 NN denotes µm
T17909 39023-39026 CC denotes and
T17910 39027-39029 CD denotes 40
T17911 39030-39032 NN denotes µm
T17912 39033-39038 NN denotes nylon
T17913 39039-39043 NN denotes mesh
T17914 39045-39048 IN denotes For
T17915 39049-39052 DT denotes the
T17916 39053-39064 NN denotes preparation
T17917 39065-39067 IN denotes of
T17918 39068-39071 NN denotes BAL
T17919 39071-39072 -COMMA- denotes ,
T17920 39073-39080 NN denotes trachea
T17921 39081-39085 VB denotes were
T17922 39086-39095 VB denotes canulated
T17923 39096-39099 CC denotes and
T17924 39100-39106 NN denotes airway
T17925 39107-39112 NN denotes lumen
T17926 39113-39116 VB denotes was
T17927 39117-39124 VB denotes flushed
T17928 39125-39126 CD denotes 4
T17929 39127-39132 NN denotes times
T17930 39133-39137 IN denotes with
T17931 39138-39142 NN denotes HBSS
T17932 39143-39147 IN denotes with
T17933 39148-39149 CD denotes 1
T17934 39150-39152 NN denotes mM
T17935 39153-39157 NN denotes EDTA
T17936 39657-39666 NN denotes Propidium
T17937 39667-39673 NN denotes iodide
T17938 39674-39677 VB denotes was
T17939 39678-39682 VB denotes used
T17940 39683-39685 TO denotes to
T17941 39686-39698 VB denotes discriminate
T17942 39699-39706 IN denotes between
T17943 39707-39711 JJ denotes live
T17944 39712-39715 CC denotes and
T17945 39716-39720 JJ denotes dead
T17946 39721-39726 NN denotes cells
T18305 39729-39737 NN denotes Cytokine
T18306 39738-39752 NN denotes quantification
T18307 39753-39756 IN denotes For
T18308 39757-39760 NN denotes TNF
T18309 39761-39766 NN denotes ELISA
T18310 39766-39767 -COMMA- denotes ,
T18311 39768-39775 JJ denotes 96-well
T18312 39776-39782 NN denotes plates
T18313 39783-39787 VB denotes were
T18314 39788-39794 VB denotes coated
T18315 39795-39799 IN denotes with
T18316 39800-39803 NN denotes TNF
T18317 39804-39811 NN denotes coating
T18318 39812-39813 -LRB- denotes (
T18319 39813-39819 NN denotes TN3-19
T18320 39819-39820 -COMMA- denotes ,
T18321 39821-39832 NN denotes eBioscience
T18322 39832-39833 -RRB- denotes )
T18323 39834-39837 CC denotes and
T18324 39838-39847 NN denotes detection
T18325 39848-39849 -LRB- denotes (
T18326 39849-39855 NN denotes R4-6A2
T18327 39855-39856 -COMMA- denotes ,
T18328 39857-39868 NN denotes eBioscience
T18329 39868-39869 -RRB- denotes )
T18330 39870-39880 NN denotes antibodies
T18331 39882-39886 NN denotes IFNα
T18332 39887-39890 CC denotes and
T18333 39891-39895 NN denotes IFNβ
T18334 39896-39903 NN denotes protein
T18335 39904-39910 NN denotes levels
T18336 39911-39915 VB denotes were
T18337 39916-39926 VB denotes determined
T18338 39927-39931 IN denotes with
T18339 39932-39934 DT denotes an
T18340 39935-39940 NN denotes ELISA
T18341 39941-39944 NN denotes kit
T18342 39945-39946 -LRB- denotes (
T18343 39946-39949 NN denotes PBL
T18344 39950-39960 NNP denotes Biomedical
T18345 39961-39973 NNP denotes Laboratories
T18346 39973-39974 -RRB- denotes )
T18347 39976-39979 IN denotes For
T18348 39980-39984 NNP denotes IFNγ
T18349 39985-39990 NNP denotes ELISA
T18350 39990-39991 -COMMA- denotes ,
T18351 39992-39999 JJ denotes 96-well
T18352 40000-40006 NN denotes plates
T18353 40007-40011 VB denotes were
T18354 40012-40018 VB denotes coated
T18355 40019-40023 IN denotes with
T18356 40024-40028 NN denotes IFNγ
T18357 40029-40036 NN denotes coating
T18358 40037-40038 -LRB- denotes (
T18359 40038-40044 NN denotes XMG1.2
T18360 40044-40045 -RRB- denotes )
T18361 40046-40049 CC denotes and
T18362 40050-40059 NN denotes detection
T18363 40060-40061 -LRB- denotes (
T18364 40061-40067 NN denotes R4-6A2
T18365 40067-40068 -RRB- denotes )
T18366 40069-40079 NN denotes antibodies
T18367 40080-40081 -LRB- denotes (
T18368 40081-40093 NN denotes eBiosciences
T18369 40093-40094 -RRB- denotes )
T18370 40096-40105 NN denotes Detection
T18371 40106-40108 IN denotes of
T18372 40109-40114 NN denotes MCP-1
T18373 40114-40115 -COMMA- denotes ,
T18374 40116-40118 NN denotes KC
T18375 40118-40119 -COMMA- denotes ,
T18376 40120-40123 NN denotes TNF
T18377 40123-40124 -COMMA- denotes ,
T18378 40125-40130 NN denotes IL-1β
T18379 40131-40134 CC denotes and
T18380 40135-40139 NN denotes IL-6
T18381 40140-40142 IN denotes in
T18382 40143-40146 NN denotes BAL
T18383 40147-40152 NN denotes fluid
T18384 40153-40156 VB denotes was
T18385 40157-40166 VB denotes performed
T18386 40167-40172 VB denotes using
T18387 40173-40180 NNP denotes Bioplex
T18388 40181-40182 -LRB- denotes (
T18389 40182-40188 NNP denotes BioRad
T18390 40188-40189 -RRB- denotes )
T18391 40190-40200 NN denotes technology
T18392 40201-40210 VB denotes according
T18393 40211-40213 TO denotes to
T18394 40214-40217 DT denotes the
T18395 40218-40230 NN denotes manufacturer
T18396 40230-40232 POS denotes 's
T18397 40233-40245 NN denotes instructions
T18398 40247-40256 NNP denotes Milliplex
T18399 40257-40267 NN denotes technology
T18400 40268-40269 -LRB- denotes (
T18401 40269-40278 NN denotes Millipore
T18402 40278-40279 -RRB- denotes )
T18403 40280-40283 VB denotes was
T18404 40284-40288 VB denotes used
T18405 40289-40292 IN denotes for
T18406 40293-40296 DT denotes the
T18407 40297-40306 NN denotes detection
T18408 40307-40309 IN denotes of
T18409 40310-40315 NN denotes MIP-2
T18410 40316-40318 IN denotes in
T18411 40319-40322 NN denotes BAL
T18412 40323-40328 NN denotes fluid
T18695 40331-40334 NN denotes RNA
T18696 40335-40344 NN denotes isolation
T18697 40344-40345 -COMMA- denotes ,
T18698 40346-40350 NN denotes cDNA
T18699 40351-40360 NN denotes synthesis
T18700 40361-40364 CC denotes and
T18701 40365-40369 NN denotes qPCR
T18702 40370-40375 JJ denotes Total
T18703 40376-40379 NN denotes RNA
T18704 40380-40383 VB denotes was
T18705 40384-40393 VB denotes extracted
T18706 40394-40399 VB denotes using
T18707 40400-40405 NNP denotes Aurum
T18708 40406-40411 NNP denotes Total
T18709 40412-40415 NN denotes RNA
T18710 40416-40420 NN denotes mini
T18711 40421-40424 NN denotes kit
T18712 40425-40426 -LRB- denotes (
T18713 40426-40432 NN denotes BioRad
T18714 40432-40433 -RRB- denotes )
T18715 40434-40437 CC denotes and
T18716 40438-40445 NN denotes reverse
T18717 40446-40457 VB denotes transcribed
T18718 40458-40462 IN denotes into
T18719 40463-40467 NN denotes cDNA
T18720 40468-40472 IN denotes with
T18721 40473-40480 NN denotes iScript
T18722 40481-40485 NN denotes cDNA
T18723 40486-40495 NN denotes synthesis
T18724 40496-40499 NN denotes kit
T18725 40500-40501 -LRB- denotes (
T18726 40501-40507 NN denotes BioRad
T18727 40507-40508 -RRB- denotes )
T18728 40509-40518 VB denotes according
T18729 40519-40521 TO denotes to
T18730 40522-40525 DT denotes the
T18731 40526-40538 NN denotes manufacturer
T18732 40538-40540 POS denotes 's
T18733 40541-40554 NN denotes instructions.
T18734 40555-40559 NN denotes qPCR
T18735 40560-40563 VB denotes was
T18736 40564-40573 VB denotes performed
T18737 40574-40576 IN denotes by
T18738 40577-40582 VB denotes using
T18739 40583-40587 NNP denotes SYBR
T18740 40588-40593 NNP denotes Green
T18741 40594-40595 NNP denotes I
T18742 40596-40602 NN denotes master
T18743 40603-40606 NN denotes mix
T18744 40607-40608 CD denotes I
T18745 40609-40610 -LRB- denotes (
T18746 40610-40615 NNP denotes Roche
T18747 40615-40616 -RRB- denotes )
T18748 40617-40619 IN denotes in
T18749 40620-40623 DT denotes the
T18750 40624-40635 NNP denotes Lightcycler
T18751 40636-40639 CD denotes 480
T18752 40640-40649 NN denotes detection
T18753 40650-40656 NN denotes system
T18754 40657-40658 -LRB- denotes (
T18755 40658-40663 NN denotes Roche
T18756 40663-40664 -RRB- denotes )
T18757 40665-40669 IN denotes with
T18758 40670-40673 DT denotes the
T18759 40674-40683 VB denotes following
T18760 40684-40691 NN denotes primers
T18761 40691-40692 -COLON- denotes :
T18762 40693-40697 NN denotes HPRT
T18763 40697-40698 -COLON- denotes :
T18764 40699-40726 NN denotes 5′-AGTGTTGGATACAGGCCAGAC-3′
T18765 40727-40730 CC denotes and
T18766 40731-40757 NN denotes 5′CGTGATTCAAATCCCTGAAGT-3′
T18767 40757-40758 -COLON- denotes ;
T18768 40759-40763 NN denotes IL-6
T18769 40763-40764 -COLON- denotes :
T18770 40765-40794 NN denotes 5′-GAGGATACCACTCCCAACAGACC-3′
T18771 40795-40798 CC denotes and
T18772 40799-40829 NN denotes 5′-AAGTGCATCATCGTTGTTCATACA-3′
T18773 40829-40830 -COLON- denotes ;
T18774 40831-40835 NN denotes IFNβ
T18775 40835-40836 -COLON- denotes :
T18776 40837-40863 NN denotes 5′-TCAGAATGAGTGGTGGTTGC-3′
T18777 40864-40867 CC denotes and
T18778 40868-40898 NN denotes 5′-GACCTTTCAAATGCAGTAGATTCA-3′
T18779 40898-40899 -COLON- denotes ;
T18780 40900-40903 NN denotes A20
T18781 40903-40904 -COLON- denotes :
T18782 40905-40933 NN denotes 5′-AAACCAATGGTGATGGAAACTG-3′
T18783 40934-40937 CC denotes and
T18784 40938-40964 NN denotes 5′-GTTGTCCCATTCGTCATTCC-3′
T18785 40964-40965 -COLON- denotes ;
T18786 40966-40970 NN denotes CCL2
T18787 40970-40971 -COLON- denotes :
T18788 40972-41001 NN denotes 5′-TTAAAAACCTGGATCGGAACCAA-3′
T18789 41002-41005 CC denotes and
T18790 41006-41035 NN denotes 5′-GCATTAGCTTCAGATTTACGGGT-3′
T18791 41035-41036 -COLON- denotes ;
T18792 41037-41042 NN denotes CXCL1
T18793 41042-41043 -COLON- denotes :
T18794 41044-41070 NN denotes 5′-GAGCCTCTAACCAGTTCCAG-3′
T18795 41071-41074 CC denotes and
T18796 41075-41101 NN denotes 5′-TGAGTGTGGCTATGACTTCG-3′
T18797 41102-41105 CC denotes and
T18798 41106-41111 NN denotes IFNα4
T18799 41111-41112 -COLON- denotes :
T18800 41113-41141 NN denotes 5′-TGATGAGCTACTACTGGTCAGC-3′
T18801 41142-41145 CC denotes and
T18802 41146-41174 NN denotes 5′-GATCTCTTAGCACAAGGATGGC-3′
T18803 41176-41183 NN denotes Primers
T18804 41184-41188 VB denotes were
T18805 41189-41197 VB denotes designed
T18806 41198-41202 IN denotes with
T18807 41203-41213 NN denotes PerlPrimer
T18808 41214-41215 -LRB- denotes (
T18809 41215-41219 NN denotes http
T18810 41219-41220 -COLON- denotes :
T18811 41220-41248 LS denotes //perlprimer.sourceforge.net
T18812 41248-41249 -RRB- denotes )
T18813 41251-41265 NN denotes Quantification
T18814 41266-41269 VB denotes was
T18815 41270-41279 VB denotes performed
T18816 41280-41285 VB denotes using
T18817 41286-41289 DT denotes the
T18818 41290-41301 JJ denotes comparative
T18819 41302-41304 NN denotes CT
T18820 41305-41311 NN denotes method
T18821 41312-41313 -LRB- denotes (
T18822 41313-41317 NN denotes ΔΔCT
T18823 41317-41318 -RRB- denotes )
T18824 41320-41327 NN denotes Results
T18825 41328-41331 VB denotes are
T18826 41332-41341 VB denotes expressed
T18827 41342-41350 JJ denotes relative
T18828 41351-41353 TO denotes to
T18829 41354-41358 NN denotes HPRT
T18830 41359-41365 NN denotes values
T19107 41368-41378 NN denotes Statistics
T19108 41379-41386 NN denotes Results
T19109 41387-41390 VB denotes are
T19110 41391-41400 VB denotes expressed
T19111 41401-41403 IN denotes as
T19112 41404-41407 DT denotes the
T19113 41408-41412 JJ denotes mean
T19114 41413-41414 NN denotes ±
T19115 41415-41418 NN denotes SEM
T19116 41420-41431 JJ denotes Statistical
T19117 41432-41444 NN denotes significance
T19118 41445-41452 IN denotes between
T19119 41453-41459 NN denotes groups
T19120 41460-41463 VB denotes was
T19121 41464-41472 VB denotes assessed
T19122 41473-41478 VB denotes using
T19123 41479-41486 JJ denotes two-way
T19124 41487-41492 NN denotes ANOVA
T19125 41494-41497 DT denotes The
T19126 41498-41509 NN denotes differences
T19127 41510-41513 IN denotes for
T19128 41514-41516 FW denotes in
T19129 41517-41521 FW denotes vivo
T19130 41522-41533 NN denotes experiments
T19131 41534-41535 -LRB- denotes (
T19132 41535-41537 IN denotes at
T19133 41538-41543 JJ denotes least
T19134 41544-41545 CD denotes 5
T19135 41546-41550 NN denotes mice
T19136 41551-41554 IN denotes per
T19137 41555-41560 NN denotes group
T19138 41560-41561 -RRB- denotes )
T19139 41562-41566 VB denotes were
T19140 41567-41577 VB denotes calculated
T19141 41578-41583 VB denotes using
T19142 41584-41587 DT denotes the
T19143 41588-41600 NNP denotes Mann-Whitney
T19144 41601-41607 NNP denotes U-test
T19145 41608-41611 IN denotes for
T19146 41612-41620 JJ denotes unpaired
T19147 41621-41625 NN denotes data
T19148 41627-41638 JJ denotes Statistical
T19149 41639-41651 NN denotes significance
T19150 41652-41654 IN denotes of
T19151 41655-41666 NN denotes differences
T19152 41667-41674 IN denotes between
T19153 41675-41683 NN denotes survival
T19154 41684-41689 NN denotes rates
T19155 41690-41693 VB denotes was
T19156 41694-41702 VB denotes analyzed
T19157 41703-41705 IN denotes by
T19158 41706-41715 VB denotes comparing
T19159 41716-41728 NNP denotes Kaplan-Meier
T19160 41729-41735 NN denotes curves
T19161 41736-41741 VB denotes using
T19162 41742-41745 DT denotes the
T19163 41746-41754 JJ denotes log-rank
T19164 41755-41759 NN denotes test
T19165 41760-41761 -LRB- denotes (
T19166 41761-41769 NNP denotes GraphPad
T19167 41770-41775 NNP denotes Prism
T19168 41776-41783 NN denotes version
T19169 41784-41785 CD denotes 5
T19170 41785-41786 -COMMA- denotes ,
T19171 41787-41795 NNP denotes GraphPad
T19172 41795-41796 -COMMA- denotes ,
T19173 41797-41800 NNP denotes San
T19174 41801-41806 NNP denotes Diego
T19175 41806-41807 -COMMA- denotes ,
T19176 41808-41810 NNP denotes CA
T19177 41810-41811 -RRB- denotes )
R1 T69 T70 arg1Of A20,(
R10 T82 T78 arg2Of Infection,against
R100 T170 T167 arg1Of mice,specific
R1000 T1733 T1731 arg1Of response,the
R1001 T1733 T1732 arg1Of response,proinflammatory
R1002 T1733 T1734 arg1Of response,to
R1003 T1735 T1734 arg2Of IAV,to
R1004 T1737 T1736 arg1Of but,","
R1005 T1739 T1738 arg1Of initiation,the
R1006 T1739 T1740 arg1Of initiation,of
R1007 T1739 T1747 arg1Of initiation,depends
R1008 T1745 T1740 arg2Of response,of
R1009 T1745 T1741 arg1Of response,the
R101 T170 T168 arg1Of mice,A20
R1010 T1745 T1742 arg1Of response,innate
R1011 T1745 T1743 arg1Of response,antiviral
R1012 T1745 T1744 arg1Of response,immune
R1013 T1747 T1737 arg2Of depends,but
R1014 T1747 T1746 arg1Of depends,largely
R1015 T1747 T1748 arg1Of depends,on
R1016 T1747 T1752 arg1Of depends,[
R1017 T1751 T1748 arg2Of signaling,on
R1018 T1751 T1749 arg1Of signaling,RIG-I
R1019 T1751 T1750 arg2Of signaling,mediated
R102 T170 T169 arg1Of mice,knockout
R1020 T1753 T1752 arg2Of 13,[
R1021 T1754 T1752 arg3Of ],[
R1022 T1759 T1757 arg1Of mice,RIG-I
R1023 T1759 T1758 arg1Of mice,deficient
R1024 T1759 T1760 arg1Of mice,are
R1025 T1759 T1762 arg1Of mice,susceptible
R1026 T1760 T1755 arg1Of are,Interestingly
R1027 T1760 T1756 arg1Of are,","
R1028 T1760 T1768 arg1Of are,","
R1029 T1760 T1769 arg1Of are,[
R103 T172 T171 arg1Of examine,to
R1030 T1760 T1772 arg1Of are,","
R1031 T1760 T1773 arg1Of are,whereas
R1032 T1762 T1760 arg2Of susceptible,are
R1033 T1762 T1761 arg1Of susceptible,highly
R1034 T1762 T1763 arg1Of susceptible,to
R1035 T1764 T1763 arg2Of IAV,to
R1036 T1764 T1765 arg1Of IAV,[
R1037 T1766 T1765 arg2Of 14,[
R1038 T1767 T1765 arg3Of ],[
R1039 T1770 T1769 arg2Of 15,[
R104 T174 T172 arg2Of role,examine
R1040 T1771 T1769 arg3Of ],[
R1041 T1776 T1774 arg1Of mice,TLR3
R1042 T1776 T1775 arg1Of mice,deficient
R1043 T1776 T1777 arg1Of mice,have
R1044 T1777 T1773 arg2Of have,whereas
R1045 T1777 T1781 arg1Of have,to
R1046 T1780 T1777 arg2Of advantage,have
R1047 T1780 T1778 arg1Of advantage,a
R1048 T1780 T1779 arg1Of advantage,survival
R1049 T1783 T1781 arg2Of infection,to
R105 T174 T173 arg1Of role,the
R1050 T1783 T1782 arg1Of infection,acute
R1051 T1783 T1784 arg1Of infection,[
R1052 T1785 T1784 arg2Of 16,[
R1053 T1786 T1784 arg3Of ],[
R1054 T1788 T1787 arg1Of results,These
R1055 T1788 T1789 arg1Of results,indicate
R1056 T1792 T1791 arg1Of imbalance,an
R1057 T1792 T1793 arg1Of imbalance,between
R1058 T1792 T1805 arg1Of imbalance,is
R1059 T1792 T1806 arg1Of imbalance,likely
R106 T174 T175 arg1Of role,of
R1060 T1792 T1808 arg1Of imbalance,contribute
R1061 T1795 T1796 arg1Of beneficial,and
R1062 T1797 T1796 arg2Of harmful,and
R1063 T1798 T1793 arg2Of effects,between
R1064 T1798 T1794 arg1Of effects,the
R1065 T1798 T1795 arg1Of effects,beneficial
R1066 T1798 T1797 arg1Of effects,harmful
R1067 T1798 T1799 arg1Of effects,of
R1068 T1800 T1799 arg2Of mediators,of
R1069 T1800 T1801 arg2Of mediators,released
R107 T174 T180 arg1Of role,in
R1070 T1804 T1801 arg1Of cells,released
R1071 T1804 T1802 arg2Of cells,by
R1072 T1804 T1803 arg1Of cells,immune
R1073 T1805 T1789 arg2Of is,indicate
R1074 T1805 T1790 arg1Of is,that
R1075 T1806 T1805 arg2Of likely,is
R1076 T1808 T1806 arg2Of contribute,likely
R1077 T1808 T1807 arg1Of contribute,to
R1078 T1808 T1809 arg1Of contribute,to
R1079 T1811 T1809 arg2Of pathogenesis,to
R108 T179 T175 arg2Of A20,of
R1080 T1811 T1810 arg1Of pathogenesis,the
R1081 T1811 T1812 arg1Of pathogenesis,of
R1082 T1813 T1812 arg2Of influenza,of
R1083 T1814 T1815 arg1Of RIG-I,contains
R1084 T1821 T1815 arg2Of domain,contains
R1085 T1821 T1816 arg1Of domain,a
R1086 T1821 T1817 arg1Of domain,C-terminal
R1087 T1821 T1818 arg1Of domain,DExD/H
R1088 T1821 T1819 arg1Of domain,box
R1089 T1821 T1820 arg1Of domain,helicase
R109 T179 T176 arg1Of A20,the
R1090 T1821 T1822 arg1Of domain,","
R1091 T1821 T1823 arg1Of domain,which
R1092 T1821 T1824 arg1Of domain,is
R1093 T1821 T1825 arg2Of domain,required
R1094 T1825 T1824 arg2Of required,is
R1095 T1825 T1826 arg1Of required,for
R1096 T1828 T1827 arg1Of recognition,ligand
R10962 T14803 T14802 arg1Of statement,Ethics
R10963 T14805 T14804 arg1Of experiments,All
R10964 T14805 T14806 arg1Of experiments,on
R10965 T14805 T14808 arg1Of experiments,were
R10966 T14805 T14809 arg2Of experiments,conducted
R10967 T14807 T14806 arg2Of mice,on
R10968 T14809 T14808 arg2Of conducted,were
R10969 T14809 T14810 arg1Of conducted,according
R1097 T1828 T1830 arg1Of recognition,and
R10970 T14811 T14810 arg2Of to,according
R10971 T14813 T14814 arg1Of national,(
R10972 T14813 T14826 arg1Of national,and
R10973 T14816 T14815 arg1Of Law,Belgian
R10974 T14816 T14817 arg1Of Law,14/08/1986
R10975 T14816 T14818 arg1Of Law,and
R10976 T14818 T14814 arg2Of and,(
R10977 T14819 T14818 arg2Of 22/12/2003,and
R10978 T14819 T14820 arg1Of 22/12/2003,","
R10979 T14823 T14820 arg2Of Decree,","
R1098 T1830 T1826 arg2Of and,for
R10980 T14823 T14821 arg1Of Decree,Belgian
R10981 T14823 T14822 arg1Of Decree,Royal
R10982 T14823 T14824 arg1Of Decree,06/04/2010
R10983 T14825 T14814 arg3Of ),(
R10984 T14826 T14811 arg2Of and,to
R10985 T14826 T14812 arg1Of and,the
R10986 T14827 T14828 arg1Of European,(
R10987 T14831 T14828 arg2Of 2010/63/EU,(
R10988 T14831 T14829 arg1Of 2010/63/EU,EU
R10989 T14831 T14830 arg1Of 2010/63/EU,Directives
R1099 T1830 T1829 arg1Of and,","
R10990 T14831 T14832 arg1Of 2010/63/EU,","
R10991 T14833 T14832 arg2Of 86/609/EEG,","
R10992 T14834 T14828 arg3Of ),(
R10993 T14836 T14826 arg2Of regulations,and
R10994 T14836 T14827 arg1Of regulations,European
R10995 T14836 T14835 arg1Of regulations,animal
R10996 T14838 T14837 arg1Of protocols,Animal
R10997 T14838 T14839 arg1Of protocols,were
R10998 T14838 T14840 arg2Of protocols,approved
R10999 T14840 T14839 arg2Of approved,were
R11 T82 T79 arg1Of Infection,Influenza
R110 T179 T177 arg1Of A20,ubiquitin-editing
R1100 T1834 T1830 arg2Of domains,and
R11000 T14844 T14840 arg1Of committee,approved
R11001 T14844 T14841 arg2Of committee,by
R11002 T14844 T14842 arg1Of committee,the
R11003 T14844 T14843 arg1Of committee,ethics
R11004 T14844 T14845 arg1Of committee,of
R11005 T14847 T14845 arg2Of University,of
R11006 T14847 T14846 arg1Of University,Ghent
R11007 T14847 T14848 arg1Of University,(
R11008 T14851 T14848 arg2Of LA1400091,(
R11009 T14851 T14849 arg1Of LA1400091,permit
R1101 T1834 T1831 arg1Of domains,two
R11010 T14851 T14850 arg1Of LA1400091,number
R11011 T14851 T14852 arg1Of LA1400091,","
R11012 T14854 T14852 arg2Of ID,","
R11013 T14854 T14853 arg1Of ID,approval
R11014 T14854 T14855 arg1Of ID,2010/001
R11015 T14856 T14848 arg3Of ),(
R11016 T14858 T14857 arg1Of efforts,All
R11017 T14858 T14859 arg1Of efforts,were
R11018 T14858 T14860 arg2Of efforts,made
R11019 T14860 T14859 arg2Of made,were
R1102 T1834 T1832 arg1Of domains,N-terminal
R11020 T14860 T14861 modOf made,to
R11021 T14862 T14861 arg1Of ameliorate,to
R11022 T14863 T14862 arg2Of suffering,ameliorate
R11023 T14863 T14864 arg1Of suffering,of
R11024 T14865 T14864 arg2Of animals,of
R11025 T14866 T14867 arg1Of Mice,were
R11026 T14866 T14868 arg2Of Mice,anesthetized
R11027 T14868 T14867 arg2Of anesthetized,were
R11028 T14870 T14871 arg1Of intraperitoneal,(
R11029 T14872 T14871 arg2Of i.p.,(
R1103 T1834 T1833 arg1Of domains,CARD
R11030 T14873 T14871 arg3Of ),(
R11031 T14874 T14868 arg1Of injection,anesthetized
R11032 T14874 T14869 arg2Of injection,by
R11033 T14874 T14870 arg1Of injection,intraperitoneal
R11034 T14874 T14875 arg1Of injection,of
R11035 T14877 T14875 arg2Of mixture,of
R11036 T14877 T14876 arg1Of mixture,a
R11037 T14877 T14878 arg1Of mixture,of
R11038 T14879 T14880 arg1Of ketamine,(
R11039 T14879 T14884 arg1Of ketamine,and
R1104 T1837 T1835 arg2Of binding,Upon
R11040 T14882 T14880 arg2Of mg/kg,(
R11041 T14882 T14881 arg1Of mg/kg,12
R11042 T14883 T14880 arg3Of ),(
R11043 T14884 T14878 arg2Of and,of
R11044 T14885 T14884 arg2Of xylazine,and
R11045 T14885 T14886 arg1Of xylazine,(
R11046 T14888 T14886 arg2Of mg/kg,(
R11047 T14888 T14887 arg1Of mg/kg,60
R11048 T14889 T14886 arg3Of ),(
R1105 T1837 T1836 arg1Of binding,ligand
R1106 T1841 T1839 arg1Of domains,the
R1107 T1841 T1840 arg1Of domains,CARD
R1108 T1841 T1842 arg1Of domains,of
R1109 T1841 T1844 arg1Of domains,associate
R111 T179 T178 arg1Of A20,protein
R1110 T1843 T1842 arg2Of RIG-I,of
R1111 T1844 T1835 arg1Of associate,Upon
R1112 T1844 T1838 arg1Of associate,","
R1113 T1844 T1845 arg1Of associate,with
R1114 T1848 T1845 arg2Of domain,with
R11141 T15002 T15001 arg1Of mice,A20fl/fl
R11142 T15002 T15003 arg1Of mice,were
R11143 T15002 T15004 arg2Of mice,generated
R11144 T15004 T15003 arg2Of generated,were
R11145 T15004 T15005 arg1Of generated,as
R11146 T15007 T15006 arg1Of described,previously
R11147 T15009 T15005 arg2Of 56,as
R11148 T15009 T15007 arg1Of 56,described
R11149 T15009 T15008 arg2Of 56,[
R1115 T1848 T1846 arg1Of domain,the
R11150 T15010 T15008 arg3Of ],[
R11151 T15012 T15011 arg1Of mice,A20fl/fl
R11152 T15012 T15013 arg1Of mice,were
R11153 T15012 T15014 arg2Of mice,crossed
R11154 T15012 T15043 arg1Of mice,are
R11155 T15012 T15044 arg2Of mice,described
R11156 T15014 T15013 arg2Of crossed,were
R11157 T15014 T15015 arg1Of crossed,with
R11158 T15014 T15037 modOf crossed,to
R11159 T15014 T15042 arg1Of crossed,and
R1116 T1848 T1847 arg1Of domain,CARD
R11160 T15017 T15015 arg2Of mice,with
R11161 T15017 T15016 arg1Of mice,LysM-Cre
R11162 T15017 T15018 arg1Of mice,[
R11163 T15017 T15021 arg1Of mice,(
R11164 T15019 T15018 arg2Of 84,[
R11165 T15020 T15018 arg3Of ],[
R11166 T15022 T15021 arg2Of provided,(
R11167 T15025 T15024 arg1Of Förster,I.
R11168 T15025 T15026 arg1Of Förster,","
R11169 T15026 T15030 arg1Of ",",","
R1117 T1848 T1849 arg1Of domain,of
R11170 T15027 T15026 arg2Of Institute,","
R11171 T15027 T15028 arg1Of Institute,of
R11172 T15029 T15028 arg2Of Genetics,of
R11173 T15030 T15022 arg1Of ",",provided
R11174 T15030 T15023 arg2Of ",",by
R11175 T15030 T15034 arg1Of ",",","
R11176 T15031 T15030 arg2Of University,","
R11177 T15031 T15032 arg1Of University,of
R11178 T15033 T15032 arg2Of Cologne,of
R11179 T15035 T15034 arg2Of Germany,","
R1118 T1851 T1852 arg1Of MAVS,(
R11180 T15036 T15021 arg3Of ),(
R11181 T15038 T15037 arg1Of generate,to
R11182 T15041 T15038 arg2Of transgenes,generate
R11183 T15041 T15039 arg1Of transgenes,A20fl/fl
R11184 T15041 T15040 arg1Of transgenes,LysMCre
R11185 T15044 T15042 arg2Of described,and
R11186 T15044 T15043 arg2Of described,are
R11187 T15044 T15045 arg1Of described,in
R11188 T15044 T15048 arg1Of described,[
R11189 T15046 T15045 arg2Of detail,in
R1119 T1854 T1852 arg2Of termed,(
R11190 T15046 T15047 arg1Of detail,elsewhere
R11191 T15049 T15048 arg2Of 48,[
R11192 T15050 T15048 arg3Of ],[
R11193 T15051 T15052 arg1Of Mice,were
R11194 T15051 T15053 arg2Of Mice,housed
R11195 T15053 T15052 arg2Of housed,were
R11196 T15053 T15054 arg1Of housed,in
R11197 T15053 T15066 arg1Of housed,in
R11198 T15056 T15055 arg1Of ventilated,individually
R11199 T15057 T15054 arg2Of cages,in
R112 T182 T180 arg2Of response,in
R1120 T1854 T1853 arg1Of termed,also
R11200 T15057 T15056 arg1Of cages,ventilated
R11201 T15057 T15058 arg1Of cages,at
R11202 T15061 T15058 arg2Of Department,at
R11203 T15061 T15059 arg1Of Department,the
R11204 T15061 T15060 arg1Of Department,VIB
R11205 T15061 T15062 arg1Of Department,of
R11206 T15065 T15062 arg2Of Research,of
R11207 T15065 T15063 arg1Of Research,Molecular
R11208 T15065 T15064 arg1Of Research,Biomedical
R11209 T15070 T15066 arg2Of facilities,in
R1121 T1855 T1854 arg3Of IPS-1,termed
R11210 T15070 T15067 arg1Of facilities,specific
R11211 T15070 T15068 arg1Of facilities,pathogen-free
R11212 T15070 T15069 arg1Of facilities,animal
R11213 T15072 T15071 arg1Of infections,Influenza
R11214 T15072 T15073 arg1Of infections,were
R11215 T15072 T15074 arg2Of infections,performed
R11216 T15074 T15073 arg2Of performed,were
R11217 T15074 T15075 arg1Of performed,on
R11218 T15076 T15077 arg1Of age-,(
R11219 T15076 T15085 arg1Of age-,and
R1122 T1855 T1856 arg1Of IPS-1,","
R11220 T15079 T15080 arg1Of 7,and
R11221 T15080 T15078 arg1Of and,between
R11222 T15081 T15080 arg2Of 9,and
R11223 T15082 T15077 arg2Of weeks,(
R11224 T15082 T15079 arg1Of weeks,7
R11225 T15082 T15081 arg1Of weeks,9
R11226 T15082 T15083 arg1Of weeks,old
R11227 T15084 T15077 arg3Of ),(
R11228 T15085 T15075 arg2Of and,on
R11229 T15087 T15085 arg2Of littermates,and
R1123 T1855 T1858 arg1Of IPS-1,","
R11230 T15087 T15086 arg1Of littermates,sex-matched
R11231 T15090 T15088 arg1Of animals,A20fl/fl
R11232 T15090 T15089 arg1Of animals,LysM-Cre
R11233 T15090 T15091 arg1Of animals,were
R11234 T15090 T15092 arg2Of animals,backcrossed
R11235 T15092 T15091 arg2Of backcrossed,were
R11236 T15092 T15094 arg1Of backcrossed,times
R11237 T15092 T15095 arg1Of backcrossed,to
R11238 T15094 T15093 arg1Of times,three
R11239 T15098 T15095 arg2Of background,to
R1124 T1855 T1859 arg1Of IPS-1,Cardif
R11240 T15098 T15096 arg1Of background,the
R11241 T15098 T15097 arg1Of background,C57Bl/6
R11242 T15100 T15099 arg1Of mice,A20fl/fl
R11243 T15100 T15101 arg1Of mice,expressing
R11244 T15100 T15103 arg1Of mice,lacking
R11245 T15100 T15107 arg1Of mice,were
R11246 T15100 T15108 arg2Of mice,termed
R11247 T15101 T15102 arg1Of expressing,or
R11248 T15103 T15102 arg2Of lacking,or
R11249 T15106 T15101 arg2Of transgene,expressing
R1125 T1857 T1856 arg2Of VISA,","
R11250 T15106 T15103 arg2Of transgene,lacking
R11251 T15106 T15104 arg1Of transgene,the
R11252 T15106 T15105 arg1Of transgene,LysM-Cre
R11253 T15108 T15107 arg2Of termed,were
R11254 T15108 T15116 arg1Of termed,respectively
R11255 T15109 T15110 arg1Of A20myel-KO,and
R11256 T15110 T15108 arg3Of and,termed
R11257 T15112 T15110 arg2Of type,and
R11258 T15112 T15111 arg1Of type,wild
R11259 T15112 T15113 arg1Of type,(
R1126 T1860 T1852 arg3Of ),(
R11260 T15114 T15113 arg2Of A20myel-WT,(
R11261 T15115 T15113 arg3Of ),(
R1127 T1862 T1849 arg2Of protein,of
R1128 T1862 T1850 arg1Of protein,the
R1129 T1862 T1851 arg1Of protein,MAVS
R113 T182 T181 arg1Of response,the
R1130 T1862 T1861 arg1Of protein,adaptor
R1131 T1862 T1863 arg1Of protein,","
R1132 T1862 T1864 arg1Of protein,which
R1133 T1862 T1866 arg1Of protein,translocates
R1134 T1866 T1865 arg1Of translocates,subsequently
R1135 T1866 T1867 arg1Of translocates,to
R1136 T1866 T1870 arg1Of translocates,in
R1137 T1866 T1875 arg1Of translocates,via
R1138 T1866 T1880 arg1Of translocates,[
R1139 T1866 T1884 arg1Of translocates,[
R11393 T15296 T15295 arg1Of infection,Viral
R11394 T15296 T15297 arg1Of infection,and
R11395 T15297 T15299 arg1Of and,of
R11396 T15298 T15297 arg2Of determination,and
R11397 T15301 T15299 arg2Of titers,of
R11398 T15301 T15300 arg1Of titers,viral
R11399 T15302 T15303 arg1Of Mouse,adapted
R114 T182 T183 arg1Of response,of
R1140 T1869 T1867 arg2Of inserts,to
R11400 T15305 T15304 arg1Of X-47,IAV
R11401 T15305 T15306 arg1Of X-47,(
R11402 T15305 T15311 arg1Of X-47,was
R11403 T15305 T15312 arg2Of X-47,propagated
R11404 T15307 T15306 arg2Of H3N2,(
R11405 T15307 T15308 arg1Of H3N2,;
R11406 T15309 T15308 arg2Of PR8×A/Victoria/3/75,;
R11407 T15310 T15306 arg3Of ),(
R11408 T15312 T15303 arg2Of propagated,adapted
R11409 T15312 T15311 arg2Of propagated,was
R1141 T1869 T1868 arg1Of inserts,and
R11410 T15312 T15313 arg1Of propagated,in
R11411 T15315 T15313 arg2Of cells,in
R11412 T15315 T15314 arg1Of cells,MDCK
R11413 T15318 T15316 arg2Of inoculation,For
R11414 T15318 T15317 arg1Of inoculation,viral
R11415 T15320 T15321 arg1Of mice,were
R11416 T15320 T15322 arg2Of mice,anesthetized
R11417 T15322 T15316 arg1Of anesthetized,For
R11418 T15322 T15319 arg1Of anesthetized,","
R11419 T15322 T15321 arg2Of anesthetized,were
R1142 T1874 T1870 arg2Of membrane,in
R11420 T15325 T15322 arg1Of injection,anesthetized
R11421 T15325 T15323 arg2Of injection,by
R11422 T15325 T15324 arg1Of injection,i.p.
R11423 T15325 T15326 arg1Of injection,with
R11424 T15327 T15328 arg1Of ketamine,(
R11425 T15327 T15332 arg1Of ketamine,and
R11426 T15330 T15328 arg2Of mg/kg,(
R11427 T15330 T15329 arg1Of mg/kg,12
R11428 T15331 T15328 arg3Of ),(
R11429 T15332 T15338 arg1Of and,and
R1143 T1874 T1871 arg1Of membrane,the
R11430 T15333 T15332 arg2Of xylazine,and
R11431 T15333 T15334 arg1Of xylazine,(
R11432 T15336 T15334 arg2Of mg/kg,(
R11433 T15336 T15335 arg1Of mg/kg,60
R11434 T15337 T15334 arg3Of ),(
R11435 T15338 T15326 arg2Of and,with
R11436 T15341 T15338 arg2Of X-47,and
R11437 T15341 T15339 arg1Of X-47,50
R11438 T15341 T15340 arg1Of X-47,µl
R11439 T15341 T15342 arg2Of X-47,diluted
R1144 T1874 T1872 arg1Of membrane,outer
R11440 T15342 T15343 arg1Of diluted,in
R11441 T15344 T15345 arg1Of PBS,was
R11442 T15344 T15346 arg2Of PBS,administered
R11443 T15346 T15343 arg2Of administered,in
R11444 T15346 T15345 arg2Of administered,was
R11445 T15346 T15347 arg1Of administered,intranasally
R11446 T15349 T15350 arg1Of lethal,and
R11447 T15351 T15350 arg2Of sublethal,and
R11448 T15352 T15348 arg2Of infection,For
R11449 T15352 T15349 arg1Of infection,lethal
R1145 T1874 T1873 arg1Of membrane,mitochondrial
R11450 T15352 T15351 arg1Of infection,sublethal
R11451 T15354 T15355 arg1Of mice,received
R11452 T15355 T15348 arg1Of received,For
R11453 T15355 T15353 arg1Of received,","
R11454 T15355 T15356 arg1Of received,respectively
R11455 T15357 T15358 arg1Of 2-LD50,or
R11456 T15358 T15355 arg2Of or,received
R11457 T15360 T15358 arg2Of X-47,or
R11458 T15360 T15359 arg1Of X-47,0.05-LD50
R11459 T15362 T15361 arg1Of determine,To
R1146 T1879 T1875 arg2Of domain,via
R11460 T15365 T15362 arg2Of titers,determine
R11461 T15365 T15363 arg1Of titers,pulmonary
R11462 T15365 T15364 arg1Of titers,viral
R11463 T15371 T15362 arg1Of dose,determine
R11464 T15371 T15367 arg1Of dose,median
R11465 T15371 T15368 arg1Of dose,tissue
R11466 T15371 T15369 arg1Of dose,culture
R11467 T15371 T15370 arg1Of dose,infectious
R11468 T15371 T15372 arg1Of dose,(
R11469 T15371 T15375 arg1Of dose,was
R1147 T1879 T1876 arg1Of domain,its
R11470 T15371 T15376 arg2Of dose,measured
R11471 T15371 T15378 arg1Of dose,follows
R11472 T15373 T15372 arg2Of TCID50,(
R11473 T15374 T15372 arg3Of ),(
R11474 T15376 T15375 arg2Of measured,was
R11475 T15376 T15377 arg1Of measured,as
R11476 T15377 T15361 modOf as,To
R11477 T15377 T15366 arg1Of as,","
R11478 T15378 T15377 arg2Of follows,as
R11479 T15378 T15379 arg1Of follows,:
R1148 T1879 T1877 arg1Of domain,C-terminal
R11480 T15380 T15381 arg1Of lungs,were
R11481 T15380 T15382 arg2Of lungs,homogenized
R11482 T15382 T15379 arg2Of homogenized,:
R11483 T15382 T15381 arg2Of homogenized,were
R11484 T15382 T15383 arg1Of homogenized,with
R11485 T15386 T15383 arg2Of homogenizer,with
R11486 T15386 T15384 arg1Of homogenizer,a
R11487 T15386 T15385 arg1Of homogenizer,Polytron
R11488 T15386 T15387 arg1Of homogenizer,(
R11489 T15386 T15390 arg1Of homogenizer,in
R1149 T1879 T1878 arg1Of domain,transmembrane
R11490 T15388 T15387 arg2Of Kinematica,(
R11491 T15389 T15387 arg3Of ),(
R11492 T15391 T15390 arg2Of PBS,in
R11493 T15394 T15392 arg1Of dilutions,Eight-fold
R11494 T15394 T15393 arg1Of dilutions,serial
R11495 T15394 T15395 arg1Of dilutions,of
R11496 T15394 T15398 arg1Of dilutions,were
R11497 T15394 T15399 arg2Of dilutions,incubated
R11498 T15397 T15395 arg2Of homogenates,of
R11499 T15397 T15396 arg1Of homogenates,lung
R115 T182 T186 arg1Of response,to
R1150 T1881 T1880 arg2Of 17,[
R11500 T15399 T15398 arg2Of incubated,were
R11501 T15399 T15400 arg1Of incubated,on
R11502 T15402 T15400 arg2Of cells,on
R11503 T15402 T15401 arg1Of cells,MDCK
R11504 T15402 T15403 arg1Of cells,for
R11505 T15405 T15403 arg2Of days,for
R11506 T15405 T15404 arg1Of days,5
R11507 T15405 T15406 arg1Of days,in
R11508 T15405 T15408 arg2Of days,supplemented
R11509 T15407 T15406 arg2Of DMEM,in
R1151 T1882 T1880 arg3Of ],[
R11510 T15408 T15409 arg1Of supplemented,with
R11511 T15410 T15411 arg1Of trypsin,(
R11512 T15410 T15415 arg1Of trypsin,","
R11513 T15413 T15411 arg2Of µg/ml,(
R11514 T15413 T15412 arg1Of µg/ml,1
R11515 T15414 T15411 arg3Of ),(
R11516 T15415 T15419 arg1Of ",",","
R11517 T15416 T15417 arg1Of 2,mM
R11518 T15418 T15415 arg2Of L-glutamine,","
R11519 T15418 T15416 arg1Of L-glutamine,2
R1152 T1883 T1866 arg2Of –,translocates
R11520 T15419 T15424 arg1Of ",",and
R11521 T15420 T15421 arg1Of 0.4,mM
R11522 T15423 T15419 arg2Of pyruvate,","
R11523 T15423 T15420 arg1Of pyruvate,0.4
R11524 T15423 T15422 arg1Of pyruvate,sodium
R11525 T15424 T15409 arg2Of and,with
R11526 T15425 T15424 arg2Of antibiotics,and
R11527 T15427 T15426 arg2Of read-out,For
R11528 T15429 T15430 arg1Of 0.5,%
R11529 T15434 T15429 arg1Of cells,0.5
R1153 T1885 T1884 arg2Of 20,[
R11530 T15434 T15431 arg1Of cells,chicken
R11531 T15434 T15432 arg1Of cells,red
R11532 T15434 T15433 arg1Of cells,blood
R11533 T15434 T15435 arg1Of cells,(
R11534 T15434 T15438 arg1Of cells,were
R11535 T15434 T15439 arg2Of cells,added
R11536 T15436 T15435 arg2Of RBC,(
R11537 T15437 T15435 arg3Of ),(
R11538 T15439 T15438 arg2Of added,were
R11539 T15439 T15440 arg1Of added,and
R1154 T1886 T1884 arg3Of ],[
R11540 T15440 T15426 arg1Of and,For
R11541 T15440 T15428 arg1Of and,","
R11542 T15442 T15441 arg1Of dilution,end-point
R11543 T15442 T15443 arg1Of dilution,of
R11544 T15442 T15445 arg1Of dilution,was
R11545 T15442 T15446 arg2Of dilution,monitored
R11546 T15444 T15443 arg2Of hemagglutination,of
R11547 T15446 T15440 arg2Of monitored,and
R11548 T15446 T15445 arg2Of monitored,was
R11549 T15448 T15447 arg1Of titers,TCID50
R1155 T1887 T1888 arg1Of Signaling,downstream
R11550 T15448 T15449 arg1Of titers,were
R11551 T15448 T15451 arg2Of titers,calculated
R11552 T15451 T15449 arg2Of calculated,were
R11553 T15451 T15450 arg1Of calculated,then
R11554 T15451 T15452 arg1Of calculated,according
R11555 T15453 T15452 arg2Of to,according
R11556 T15455 T15453 arg2Of method,to
R11557 T15455 T15454 arg1Of method,the
R11558 T15455 T15456 arg1Of method,of
R11559 T15457 T15458 arg1Of Reed,and
R1156 T1887 T1891 arg1Of Signaling,requires
R11560 T15458 T15456 arg2Of and,of
R11561 T15459 T15458 arg2Of Muench,and
R11562 T15459 T15460 arg1Of Muench,[
R11563 T15461 T15460 arg2Of 85,[
R11564 T15462 T15460 arg3Of ],[
R1157 T1888 T1889 arg1Of downstream,of
R1158 T1890 T1889 arg2Of MAVS,of
R1159 T1893 T1891 arg2Of action,requires
R116 T185 T183 arg2Of cells,of
R1160 T1893 T1892 arg1Of action,the
R1161 T1893 T1894 arg1Of action,of
R1162 T1893 T1897 arg1Of action,modifying
R1163 T1896 T1894 arg2Of ubiquitin,of
R1164 T1948 T1947 arg1Of characterized,well
R1165 T1896 T1895 arg1Of ubiquitin,various
R1166 T1898 T1897 arg2Of enzymes,modifying
R1167 T1950 T1948 arg1Of ligases,characterized
R1168 T1950 T1949 arg1Of ligases,ubiquitin
R1169 T1950 T1952 arg1Of ligases,as
R117 T185 T184 arg1Of cells,myeloid
R1170 T1950 T1961 arg1Of ligases,and
R1171 T1898 T1899 arg1Of enzymes,","
R1172 T1898 T1900 arg1Of enzymes,which
R1173 T1952 T1951 arg1Of as,such
R1174 T1953 T1952 arg2Of TRAF6,as
R11746 T15676 T15677 arg1Of Determination,of
R11747 T15676 T15679 arg1Of Determination,(
R11748 T15678 T15677 arg2Of HAI,of
R11749 T15681 T15679 arg2Of inhibition,(
R1175 T1953 T1954 arg1Of TRAF6,[
R11750 T15681 T15680 arg1Of inhibition,hemagglutination
R11751 T15682 T15679 arg3Of ),(
R11752 T15683 T15676 arg1Of titers,Determination
R11753 T15685 T15684 arg1Of determine,To
R11754 T15688 T15685 arg2Of titers,determine
R11755 T15688 T15686 arg1Of titers,the
R11756 T15688 T15687 arg1Of titers,HAI
R11757 T15688 T15689 arg1Of titers,in
R11758 T15691 T15689 arg2Of mice,in
R11759 T15691 T15690 arg1Of mice,infected
R1176 T1953 T1957 arg1Of TRAF6,","
R11760 T15693 T15694 arg1Of sera,of
R11761 T15693 T15696 arg1Of sera,were
R11762 T15693 T15697 arg2Of sera,treated
R11763 T15693 T15708 arg1Of sera,remove
R11764 T15695 T15694 arg2Of these,of
R11765 T15697 T15684 modOf treated,To
R11766 T15697 T15692 arg1Of treated,","
R11767 T15697 T15696 arg2Of treated,were
R11768 T15697 T15698 arg1Of treated,with
R11769 T15697 T15707 modOf treated,to
R1177 T1953 T1958 arg1Of TRAF6,[
R11770 T15700 T15698 arg2Of enzyme,with
R11771 T15700 T15699 arg1Of enzyme,receptor-destroying
R11772 T15700 T15701 arg1Of enzyme,(
R11773 T15703 T15701 arg2Of filtrate,(
R11774 T15703 T15702 arg1Of filtrate,RDE/Cholera
R11775 T15703 T15704 arg1Of filtrate,;
R11776 T15705 T15704 arg2Of Sigma,;
R11777 T15706 T15701 arg3Of ),(
R11778 T15708 T15707 arg1Of remove,to
R11779 T15710 T15708 arg2Of acids,remove
R1178 T1955 T1954 arg2Of 25,[
R11780 T15710 T15709 arg1Of acids,sialic
R11781 T15710 T15711 arg1Of acids,from
R11782 T15713 T15711 arg2Of proteins,from
R11783 T15713 T15712 arg1Of proteins,serum
R11784 T15713 T15714 arg1Of proteins,capable
R11785 T15714 T15715 arg1Of capable,of
R11786 T15717 T15715 arg2Of inhibition,of
R11787 T15717 T15716 arg1Of inhibition,aspecific
R11788 T15717 T15718 arg1Of inhibition,of
R11789 T15719 T15718 arg2Of agglutination,of
R1179 T1898 T1905 arg1Of enzymes,regulate
R11790 T15721 T15720 arg2Of incubation,After
R11791 T15721 T15723 arg1Of incubation,at
R11792 T15723 T15722 arg1Of at,overnight
R11793 T15724 T15723 arg2Of 37°C,at
R11794 T15727 T15726 arg1Of RDE,the
R11795 T15727 T15728 arg1Of RDE,was
R11796 T15727 T15729 arg2Of RDE,inactivated
R11797 T15729 T15720 arg1Of inactivated,After
R11798 T15729 T15725 arg1Of inactivated,","
R11799 T15729 T15728 arg2Of inactivated,was
R118 T188 T186 arg2Of infection,to
R1180 T1956 T1954 arg3Of ],[
R11800 T15731 T15729 arg1Of addition,inactivated
R11801 T15731 T15730 arg2Of addition,by
R11802 T15731 T15732 arg1Of addition,of
R11803 T15736 T15733 arg1Of citrate,0.75
R11804 T15736 T15734 arg1Of citrate,%
R11805 T15736 T15735 arg1Of citrate,sodium
R11806 T15736 T15737 arg1Of citrate,in
R11807 T15736 T15739 arg1Of citrate,and
R11808 T15738 T15737 arg2Of PBS,in
R11809 T15739 T15732 arg2Of and,of
R1181 T1902 T1903 arg1Of positively,and
R11810 T15740 T15739 arg2Of heating,and
R11811 T15740 T15741 arg1Of heating,to
R11812 T15742 T15741 arg2Of 56°C,to
R11813 T15742 T15743 arg1Of 56°C,for
R11814 T15745 T15743 arg2Of min,for
R11815 T15745 T15744 arg1Of min,30
R11816 T15747 T15746 arg1Of remove,To
R11817 T15751 T15747 arg2Of proteins,remove
R11818 T15751 T15748 arg1Of proteins,sialic
R11819 T15751 T15749 arg1Of proteins,acid
R1182 T1959 T1958 arg2Of 26,[
R11820 T15751 T15750 arg1Of proteins,binding
R11821 T15753 T15747 arg1Of sera,remove
R11822 T15753 T15754 arg1Of sera,were
R11823 T15753 T15755 arg2Of sera,cleared
R11824 T15755 T15746 modOf cleared,To
R11825 T15755 T15752 arg1Of cleared,","
R11826 T15755 T15754 arg2Of cleared,were
R11827 T15755 T15756 arg1Of cleared,with
R11828 T15759 T15760 arg1Of 50,%
R11829 T15762 T15756 arg2Of RBC,with
R1183 T1960 T1958 arg3Of ],[
R11830 T15762 T15757 arg1Of RBC,1/10
R11831 T15762 T15758 arg1Of RBC,volume
R11832 T15762 T15759 arg1Of RBC,50
R11833 T15762 T15761 arg1Of RBC,chicken
R11834 T15763 T15764 arg1Of Titration,was
R11835 T15763 T15765 arg2Of Titration,done
R11836 T15765 T15764 arg2Of done,was
R11837 T15765 T15766 arg1Of done,by
R11838 T15767 T15766 arg2Of incubating,by
R11839 T15767 T15781 arg1Of incubating,for
R1184 T1961 T1966 arg1Of and,mediate
R11840 T15771 T15767 arg2Of series,incubating
R11841 T15771 T15768 arg1Of series,a
R11842 T15771 T15769 arg1Of series,two-fold
R11843 T15771 T15770 arg1Of series,dilution
R11844 T15771 T15772 arg1Of series,of
R11845 T15771 T15774 arg1Of series,with
R11846 T15773 T15772 arg2Of sera,of
R11847 T15777 T15774 arg2Of units,with
R11848 T15777 T15775 arg1Of units,4
R11849 T15777 T15776 arg1Of units,HA
R1185 T1962 T1961 arg2Of TRAF3,and
R11850 T15777 T15778 arg1Of units,of
R11851 T15780 T15778 arg2Of virus,of
R11852 T15780 T15779 arg1Of virus,X-47
R11853 T15783 T15781 arg2Of hour,for
R11854 T15783 T15782 arg1Of hour,1
R11855 T15783 T15784 arg1Of hour,at
R11856 T15786 T15784 arg2Of temperature,at
R11857 T15786 T15785 arg1Of temperature,room
R11858 T15786 T15787 arg1Of temperature,in
R11859 T15790 T15787 arg2Of plates,in
R1186 T1962 T1963 arg1Of TRAF3,[
R11860 T15790 T15788 arg1Of plates,96-well
R11861 T15790 T15789 arg1Of plates,U-bottom
R11862 T15795 T15793 arg1Of volume,an
R11863 T15795 T15794 arg1Of volume,equal
R11864 T15795 T15796 arg1Of volume,of
R11865 T15795 T15801 arg1Of volume,was
R11866 T15795 T15802 arg2Of volume,added
R11867 T15797 T15798 arg1Of 0.5,%
R11868 T15800 T15796 arg2Of RBC,of
R11869 T15800 T15797 arg1Of RBC,0.5
R1187 T1903 T1901 arg1Of and,both
R11870 T15800 T15799 arg1Of RBC,chicken
R11871 T15802 T15801 arg2Of added,was
R11872 T15802 T15803 arg1Of added,and
R11873 T15803 T15791 arg1Of and,Finally
R11874 T15803 T15792 arg1Of and,","
R11875 T15804 T15805 arg1Of titers,were
R11876 T15804 T15806 arg2Of titers,read
R11877 T15806 T15803 arg2Of read,and
R11878 T15806 T15805 arg2Of read,were
R11879 T15806 T15809 arg1Of read,later
R1188 T1964 T1963 arg2Of 27,[
R11880 T15808 T15806 arg3Of min,read
R11881 T15808 T15807 arg1Of min,30
R11882 T15811 T15810 arg1Of controls,Negative
R11883 T15811 T15812 arg1Of controls,included
R11884 T15812 T15836 arg1Of included,;
R11885 T15813 T15815 arg1Of PBS,of
R11886 T15815 T15812 arg2Of of,included
R11887 T15815 T15814 arg1Of of,instead
R11888 T15815 T15828 arg1Of of,(
R11889 T15817 T15816 arg1Of serum,immune
R1189 T1965 T1963 arg3Of ],[
R11890 T15817 T15818 arg1Of serum,(
R11891 T15817 T15822 arg1Of serum,or
R11892 T15820 T15818 arg2Of control,(
R11893 T15820 T15819 arg1Of control,agglutination
R11894 T15821 T15818 arg3Of ),(
R11895 T15822 T15815 arg2Of or,of
R11896 T15823 T15825 arg1Of PR8,of
R11897 T15825 T15822 arg2Of of,or
R11898 T15825 T15824 arg1Of of,instead
R11899 T15827 T15825 arg2Of virus,of
R119 T188 T187 arg1Of infection,IAV
R1190 T1966 T1944 arg1Of mediate,In
R11900 T15827 T15826 arg1Of virus,X-47
R11901 T15829 T15828 arg2Of control,(
R11902 T15829 T15830 arg1Of control,for
R11903 T15832 T15830 arg2Of effect,for
R11904 T15832 T15831 arg1Of effect,agglutination
R11905 T15832 T15833 arg1Of effect,of
R11906 T15834 T15833 arg2Of sera,of
R11907 T15835 T15828 arg3Of ),(
R11908 T15839 T15837 arg2Of control,as
R11909 T15839 T15838 arg1Of control,positive
R1191 T1966 T1946 arg1Of mediate,","
R11910 T15841 T15842 arg1Of serum,from
R11911 T15841 T15853 arg1Of serum,was
R11912 T15841 T15854 arg2Of serum,used
R11913 T15844 T15842 arg2Of mouse,from
R11914 T15844 T15843 arg1Of mouse,a
R11915 T15844 T15845 arg2Of mouse,infected
R11916 T15845 T15846 arg1Of infected,twice
R11917 T15845 T15847 arg1Of infected,with
R11918 T15850 T15847 arg2Of dose,with
R11919 T15850 T15848 arg1Of dose,a
R1192 T1966 T1967 arg1Of mediate,respectively
R11920 T15850 T15849 arg1Of dose,sublethal
R11921 T15850 T15851 arg1Of dose,of
R11922 T15852 T15851 arg2Of X-47,of
R11923 T15854 T15836 arg2Of used,;
R11924 T15854 T15837 arg1Of used,as
R11925 T15854 T15840 arg1Of used,","
R11926 T15854 T15853 arg2Of used,was
R1193 T1966 T1972 arg1Of mediate,upon
R1194 T1904 T1903 arg2Of negatively,and
R1195 T1968 T1969 arg1Of NF-κB,and
R1196 T1969 T1966 arg2Of and,mediate
R1197 T1905 T1902 arg1Of regulate,positively
R1198 T1971 T1969 arg2Of activation,and
R1199 T1971 T1970 arg1Of activation,IRF3
R12 T82 T80 arg1Of Infection,A
R120 T191 T189 arg1Of macrophages,A20
R1200 T1905 T1904 arg1Of regulate,negatively
R1201 T1909 T1905 arg2Of transduction,regulate
R1202 T1974 T1972 arg2Of stimulation,upon
R1203 T1974 T1973 arg1Of stimulation,RIG-I
R1204 T1978 T1975 arg2Of hand,On
R1205 T1978 T1976 arg1Of hand,the
R1206 T1978 T1977 arg1Of hand,other
R1207 T1980 T1998 arg1Of deubiquitinating,[
R1208 T1980 T2001 arg1Of deubiquitinating,and
R1209 T1981 T1980 arg2Of enzymes,deubiquitinating
R121 T191 T190 arg1Of macrophages,deficient
R1210 T1981 T1982 arg1Of enzymes,(
R1211 T1981 T1985 arg1Of enzymes,","
R1212 T1981 T1987 arg1Of enzymes,as
R12129 T16147 T16146 arg1Of vivo,In
R1213 T1981 T1997 arg1Of enzymes,","
R12130 T16149 T16150 arg1Of GrB,and
R12131 T16151 T16150 arg2Of IFNγ,and
R12132 T16152 T16147 arg1Of staining,vivo
R12133 T16152 T16148 arg1Of staining,intracellular
R12134 T16152 T16149 arg1Of staining,GrB
R12135 T16152 T16151 arg1Of staining,IFNγ
R12136 T16152 T16153 arg1Of staining,of
R12137 T16157 T16153 arg2Of cells,of
R12138 T16157 T16154 arg2Of cells,activated
R12139 T16157 T16155 arg1Of cells,CD8+
R1214 T1909 T1906 arg1Of transduction,RIG-I
R12140 T16157 T16156 arg1Of cells,T
R12141 T16159 T16158 arg1Of B,Granzyme
R12142 T16159 T16160 arg1Of B,(
R12143 T16159 T16163 arg1Of B,and
R12144 T16161 T16160 arg2Of GrB,(
R12145 T16162 T16160 arg3Of ),(
R12146 T16163 T16169 arg1Of and,were
R12147 T16163 T16170 arg2Of and,determined
R12148 T16164 T16163 arg2Of IFNγ,and
R12149 T16164 T16165 arg1Of IFNγ,expressing
R1215 T1983 T1982 arg2Of DUBs,(
R12150 T16168 T16165 arg2Of cells,expressing
R12151 T16168 T16166 arg1Of cells,CD8+
R12152 T16168 T16167 arg1Of cells,T
R12153 T16170 T16169 arg2Of determined,were
R12154 T16170 T16171 arg1Of determined,by
R12155 T16172 T16171 arg2Of treating,by
R12156 T16172 T16175 arg1Of treating,intranasally
R12157 T16172 T16176 arg1Of treating,with
R12158 T16174 T16172 arg2Of mice,treating
R12159 T16174 T16173 arg1Of mice,the
R1216 T1909 T1907 arg1Of transduction,mediated
R12160 T16180 T16176 arg2Of A,with
R12161 T16180 T16177 arg1Of A,50
R12162 T16180 T16178 arg1Of A,µg
R12163 T16180 T16179 arg1Of A,Brefeldin
R12164 T16180 T16181 arg1Of A,(
R12165 T16180 T16184 arg1Of A,as
R12166 T16182 T16181 arg2Of Sigma,(
R12167 T16183 T16181 arg3Of ),(
R12168 T16186 T16185 arg1Of described,previously
R12169 T16188 T16184 arg2Of 86,as
R1217 T1984 T1982 arg3Of ),(
R12170 T16188 T16186 arg1Of 86,described
R12171 T16188 T16187 arg2Of 86,[
R12172 T16189 T16187 arg3Of ],[
R12173 T16191 T16190 arg1Of h,6
R12174 T16194 T16195 arg1Of BAL,and
R12175 T16195 T16197 arg1Of and,were
R12176 T16195 T16198 arg2Of and,isolated
R12177 T16195 T16217 arg1Of and,were
R12178 T16195 T16218 arg2Of and,stained
R12179 T16195 T16220 arg2Of and,fixed
R1218 T1909 T1908 arg1Of transduction,signal
R12180 T16195 T16222 arg2Of and,permeabilized
R12181 T16196 T16195 arg2Of lungs,and
R12182 T16198 T16197 arg2Of isolated,were
R12183 T16198 T16199 arg1Of isolated,and
R12184 T16199 T16191 arg1Of and,h
R12185 T16199 T16192 arg1Of and,later
R12186 T16199 T16193 arg1Of and,","
R12187 T16202 T16200 arg1Of suspensions,single
R12188 T16202 T16201 arg1Of suspensions,cell
R12189 T16202 T16203 arg1Of suspensions,were
R1219 T1909 T1910 arg1Of transduction,[
R12190 T16202 T16204 arg2Of suspensions,prepared
R12191 T16204 T16203 arg2Of prepared,were
R12192 T16204 T16205 arg1Of prepared,from
R12193 T16204 T16208 arg1Of prepared,in
R12194 T16207 T16205 arg2Of lung,from
R12195 T16207 T16206 arg1Of lung,the
R12196 T16210 T16208 arg2Of presence,in
R12197 T16210 T16209 arg1Of presence,the
R12198 T16210 T16211 arg1Of presence,of
R12199 T16216 T16211 arg2Of Cells,of
R122 T191 T192 arg1Of macrophages,were
R1220 T1911 T1910 arg2Of 21,[
R12200 T16216 T16212 arg1Of Cells,3
R12201 T16216 T16213 arg1Of Cells,µg/ml
R12202 T16216 T16214 arg1Of Cells,Brefeldin
R12203 T16216 T16215 arg1Of Cells,A.
R12204 T16218 T16219 arg1Of stained,","
R12205 T16219 T16221 arg1Of ",",and
R12206 T16220 T16219 arg2Of fixed,","
R12207 T16221 T16199 arg2Of and,and
R12208 T16221 T16203 modOf and,were
R12209 T16221 T16217 arg2Of and,were
R1221 T1987 T1986 arg1Of as,such
R12210 T16221 T16223 arg1Of and,(
R12211 T16221 T16229 arg1Of and,according
R12212 T16222 T16221 arg2Of permeabilized,and
R12213 T16224 T16223 arg2Of Cytofix/Cytoperm,(
R12214 T16224 T16225 arg1Of Cytofix/Cytoperm,","
R12215 T16227 T16225 arg2Of Biosciences,","
R12216 T16227 T16226 arg1Of Biosciences,BD
R12217 T16228 T16223 arg3Of ),(
R12218 T16230 T16229 arg2Of to,according
R12219 T16232 T16231 arg1Of manufacturer,the
R1222 T1988 T1989 arg1Of DUBA,[
R12220 T16232 T16233 arg2Of manufacturer,'s
R12221 T16234 T16230 arg2Of instructions,to
R12222 T16234 T16233 arg1Of instructions,'s
R12223 T16238 T16235 arg2Of cells,Activated
R12224 T16238 T16236 arg1Of cells,CD8+
R12225 T16238 T16237 arg1Of cells,T
R12226 T16238 T16239 arg1Of cells,were
R12227 T16238 T16240 arg2Of cells,analyzed
R12228 T16240 T16239 arg2Of analyzed,were
R12229 T16243 T16240 arg1Of cytometry,analyzed
R1223 T1988 T1992 arg1Of DUBA,","
R12230 T16243 T16241 arg2Of cytometry,by
R12231 T16243 T16242 arg1Of cytometry,flow
R12232 T16243 T16244 arg2Of cytometry,based
R12233 T16244 T16245 arg1Of based,on
R12234 T16247 T16248 arg1Of CD3+,and
R12235 T16249 T16248 arg2Of CD8+,and
R12236 T16250 T16245 arg2Of expression,on
R12237 T16250 T16246 arg1Of expression,CD62lo
R12238 T16250 T16247 arg1Of expression,CD3+
R12239 T16250 T16249 arg1Of expression,CD8+
R1224 T1990 T1989 arg2Of 28,[
R12240 T16257 T16251 arg1Of kit,Live/Dead
R12241 T16257 T16252 arg1Of kit,fixable
R12242 T16257 T16253 arg1Of kit,aqua
R12243 T16257 T16254 arg1Of kit,dead
R12244 T16257 T16255 arg1Of kit,cell
R12245 T16257 T16256 arg1Of kit,stain
R12246 T16257 T16258 arg1Of kit,(
R12247 T16257 T16262 arg1Of kit,was
R12248 T16257 T16263 arg2Of kit,used
R12249 T16257 T16265 arg1Of kit,discriminate
R1225 T1991 T1989 arg3Of ],[
R12250 T16257 T16266 arg1Of kit,live
R12251 T16260 T16258 arg2Of Probes,(
R12252 T16260 T16259 arg1Of Probes,Molecular
R12253 T16261 T16258 arg3Of ),(
R12254 T16263 T16262 arg2Of used,was
R12255 T16265 T16263 arg3Of discriminate,used
R12256 T16265 T16264 arg1Of discriminate,to
R12257 T16266 T16265 arg2Of live,discriminate
R12258 T16266 T16267 arg1Of live,from
R12259 T16269 T16267 arg2Of cells,from
R1226 T1992 T1987 arg2Of ",",as
R12260 T16269 T16268 arg1Of cells,dead
R1227 T1993 T1992 arg2Of CYLD,","
R1228 T1993 T1994 arg1Of CYLD,[
R1229 T1995 T1994 arg2Of 29,[
R123 T191 T193 arg1Of macrophages,hyperresponsive
R1230 T1912 T1910 arg3Of ],[
R1231 T1996 T1994 arg3Of ],[
R1232 T1915 T1913 arg1Of ligases,K63-specific
R1233 T1999 T1998 arg2Of 30,[
R1234 T2000 T1998 arg3Of ],[
R1235 T2001 T2006 arg1Of and,have
R1236 T2001 T2007 arg1Of and,been
R1237 T2001 T2008 arg2Of and,shown
R1238 T2001 T2011 arg1Of and,regulate
R1239 T2002 T2001 arg2Of OTUB1/2,and
R124 T191 T195 arg1Of macrophages,double
R1240 T2002 T2003 arg1Of OTUB1/2,[
R1241 T2004 T2003 arg2Of 31,[
R1242 T1915 T1914 arg1Of ligases,ubiquitin
R12424 T16567 T16568 arg1Of Cells,and
R12425 T16569 T16568 arg2Of transfection,and
R12426 T16570 T16571 arg1Of HEK293T,and
R12427 T16572 T16571 arg2Of MDCK,and
R12428 T16573 T16570 arg1Of cells,HEK293T
R12429 T16573 T16572 arg1Of cells,MDCK
R1243 T2005 T2003 arg3Of ],[
R12430 T16573 T16574 arg1Of cells,were
R12431 T16573 T16575 arg2Of cells,grown
R12432 T16575 T16574 arg2Of grown,were
R12433 T16575 T16576 arg1Of grown,in
R12434 T16577 T16576 arg2Of DMEM,in
R12435 T16577 T16578 arg1Of DMEM,(
R12436 T16577 T16581 arg2Of DMEM,supplemented
R12437 T16579 T16578 arg2Of Gibco,(
R12438 T16580 T16578 arg3Of ),(
R12439 T16581 T16582 arg1Of supplemented,with
R1244 T1915 T1916 arg1Of ligases,(
R12440 T16583 T16584 arg1Of 10,%
R12441 T16585 T16583 arg1Of FCS,10
R12442 T16585 T16586 arg1Of FCS,","
R12443 T16586 T16590 arg1Of ",",","
R12444 T16587 T16588 arg1Of 2,mM
R12445 T16589 T16586 arg2Of L-glutamine,","
R12446 T16589 T16587 arg1Of L-glutamine,2
R12447 T16590 T16595 arg1Of ",",and
R12448 T16591 T16592 arg1Of 0.4,mM
R12449 T16594 T16590 arg2Of pyruvate,","
R1245 T1915 T1919 arg1Of ligases,","
R12450 T16594 T16591 arg1Of pyruvate,0.4
R12451 T16594 T16593 arg1Of pyruvate,sodium
R12452 T16595 T16582 arg2Of and,with
R12453 T16596 T16595 arg2Of antibiotics,and
R12454 T16598 T16597 arg1Of cells,HEK293T
R12455 T16598 T16599 arg1Of cells,were
R12456 T16598 T16600 arg2Of cells,transfected
R12457 T16600 T16599 arg2Of transfected,were
R12458 T16600 T16601 modOf transfected,using
R12459 T16604 T16601 arg2Of phosphate,using
R1246 T1915 T1921 arg1Of ligases,as
R12460 T16604 T16602 arg1Of phosphate,the
R12461 T16604 T16603 arg1Of phosphate,calcium
R12462 T16607 T16605 arg2Of method,precipitate
R12463 T16607 T16606 arg1Of method,transfection
R12464 T16607 T16608 arg1Of method,with
R12465 T16611 T16608 arg2Of vectors,with
R12466 T16611 T16609 arg1Of vectors,specific
R12467 T16611 T16610 arg1Of vectors,expression
R12468 T16613 T16614 arg1Of pCAGGS-E-hA20,(
R12469 T16613 T16618 arg1Of pCAGGS-E-hA20,","
R1247 T2008 T1975 arg1Of shown,On
R12470 T16615 T16614 arg2Of LMBP,(
R12471 T16615 T16616 arg1Of LMBP,3778
R12472 T16617 T16614 arg3Of ),(
R12473 T16618 T16624 arg1Of ",",","
R12474 T16619 T16618 arg2Of pCAGGS-E-RIG-I-CARD,","
R12475 T16619 T16620 arg1Of pCAGGS-E-RIG-I-CARD,(
R12476 T16621 T16620 arg2Of LMBP,(
R12477 T16621 T16622 arg1Of LMBP,6517
R12478 T16623 T16620 arg3Of ),(
R12479 T16624 T16612 arg2Of ",",(
R1248 T2008 T1979 arg1Of shown,","
R12480 T16625 T16624 arg2Of pEF-HA-IRF-7,","
R12481 T16628 T16627 arg1Of provided,kindly
R12482 T16631 T16630 arg1Of Taniguchi,T.
R12483 T16631 T16632 arg1Of Taniguchi,","
R12484 T16632 T16637 arg1Of ",",and
R12485 T16634 T16632 arg2Of School,","
R12486 T16634 T16633 arg1Of School,Graduate
R12487 T16634 T16635 arg1Of School,of
R12488 T16636 T16635 arg2Of Medicine,of
R12489 T16637 T16628 arg1Of and,provided
R1249 T2008 T2006 arg2Of shown,have
R12490 T16637 T16629 arg2Of and,by
R12491 T16638 T16637 arg2Of Faculty,and
R12492 T16638 T16639 arg1Of Faculty,of
R12493 T16640 T16639 arg2Of Medicine,of
R12494 T16642 T16641 arg2Of University,","
R12495 T16642 T16643 arg1Of University,of
R12496 T16644 T16643 arg2Of Tokyo,of
R12497 T16648 T16649 arg1Of NF-κB,","
R12498 T16649 T16651 arg1Of ",",","
R12499 T16650 T16649 arg2Of IRF3,","
R125 T192 T201 arg1Of were,","
R1250 T1915 T1931 arg1Of ligases,","
R12500 T16654 T16651 arg2Of plasmids,","
R12501 T16654 T16652 arg1Of plasmids,IRF7
R12502 T16654 T16653 arg1Of plasmids,reporter
R12503 T16657 T16658 arg1Of pConLuc,(
R12504 T16657 T16661 arg1Of pConLuc,","
R12505 T16659 T16658 arg2Of LMBP3248,(
R12506 T16660 T16658 arg3Of ),(
R12507 T16661 T16655 arg2Of ",",(
R12508 T16661 T16656 arg1Of ",",respectively
R12509 T16661 T16666 arg1Of ",",","
R1251 T2008 T2007 arg2Of shown,been
R12510 T16662 T16661 arg2Of pISRE-luc,","
R12511 T16662 T16663 arg1Of pISRE-luc,(
R12512 T16664 T16663 arg2Of LMBP4011,(
R12513 T16665 T16663 arg3Of ),(
R12514 T16667 T16668 arg1Of pGL3-IFNα4-luc,(
R12515 T16667 T16685 arg1Of pGL3-IFNα4-luc,and
R12516 T16670 T16668 arg2Of provided,(
R12517 T16670 T16669 arg1Of provided,kindly
R12518 T16673 T16672 arg1Of Hiscott,J.
R12519 T16673 T16674 arg1Of Hiscott,","
R1252 T1915 T1932 arg1Of ligases,[
R12520 T16674 T16677 arg1Of ",",","
R12521 T16676 T16674 arg2Of University,","
R12522 T16676 T16675 arg1Of University,McGill
R12523 T16677 T16679 arg1Of ",",","
R12524 T16678 T16677 arg2Of Montreal,","
R12525 T16679 T16670 arg1Of ",",provided
R12526 T16679 T16671 arg2Of ",",by
R12527 T16679 T16681 arg1Of ",",","
R12528 T16680 T16679 arg2Of Quebec,","
R12529 T16682 T16681 arg2Of Canada,","
R1253 T1915 T1936 arg1Of ligases,have
R12530 T16683 T16668 arg3Of ),(
R12531 T16685 T16666 arg2Of and,","
R12532 T16685 T16684 arg1Of and,","
R12533 T16686 T16685 arg2Of pACTbetagal,and
R12534 T16686 T16687 arg1Of pACTbetagal,(
R12535 T16688 T16687 arg2Of LMBP4341,(
R12536 T16689 T16687 arg3Of ),(
R12537 T16693 T16690 arg2Of normalization,for
R12538 T16693 T16691 arg1Of normalization,transfection
R12539 T16693 T16692 arg1Of normalization,efficiency
R1254 T2011 T2008 arg3Of regulate,shown
R12540 T16694 T16695 arg1Of Details,of
R12541 T16694 T16697 arg1Of Details,are
R12542 T16694 T16698 arg2Of Details,presented
R12543 T16696 T16695 arg2Of plasmids,of
R12544 T16698 T16697 arg2Of presented,are
R12545 T16698 T16699 arg1Of presented,along
R12546 T16698 T16704 arg1Of presented,at
R12547 T16698 T16710 arg1Of presented,:
R12548 T16698 T16711 arg1Of presented,//bccm.belspo.be/index.php
R12549 T16699 T16700 arg1Of along,with
R1255 T2011 T2009 arg1Of regulate,to
R12550 T16703 T16700 arg2Of maps,with
R12551 T16703 T16701 arg1Of maps,detailed
R12552 T16703 T16702 arg1Of maps,sequence
R12553 T16709 T16704 arg2Of http,at
R12554 T16709 T16705 arg1Of http,the
R12555 T16709 T16706 arg1Of http,BCCM-LMBP
R12556 T16709 T16707 arg1Of http,plasmid
R12557 T16709 T16708 arg1Of http,databank
R12558 T16714 T16712 arg2Of generation,For
R12559 T16714 T16713 arg1Of generation,the
R1256 T2011 T2010 arg1Of regulate,negatively
R12560 T16714 T16715 arg1Of generation,of
R12561 T16716 T16715 arg2Of BMDM,of
R12562 T16720 T16718 arg1Of cells,bone
R12563 T16720 T16719 arg1Of cells,marrow
R12564 T16720 T16721 arg1Of cells,were
R12565 T16720 T16722 arg2Of cells,cultured
R12566 T16722 T16712 arg1Of cultured,For
R12567 T16722 T16717 arg1Of cultured,","
R12568 T16722 T16721 arg2Of cultured,were
R12569 T16722 T16724 arg1Of cultured,days
R1257 T2011 T2014 arg1Of regulate,by
R12570 T16724 T16723 arg1Of days,7
R12571 T16724 T16725 arg1Of days,in
R12572 T16724 T16731 arg2Of days,supplemented
R12573 T16726 T16725 arg2Of RPMI,in
R12574 T16726 T16727 arg1Of RPMI,1640
R12575 T16726 T16728 arg1Of RPMI,(
R12576 T16729 T16728 arg2Of Gibco,(
R12577 T16730 T16728 arg3Of ),(
R12578 T16731 T16732 arg1Of supplemented,with
R12579 T16733 T16734 arg1Of 10,%
R1258 T2013 T2011 arg2Of signaling,regulate
R12580 T16735 T16733 arg1Of FCS,10
R12581 T16735 T16736 arg1Of FCS,","
R12582 T16736 T16740 arg1Of ",",","
R12583 T16737 T16738 arg1Of 2,mM
R12584 T16739 T16736 arg2Of L-glutamine,","
R12585 T16739 T16737 arg1Of L-glutamine,2
R12586 T16740 T16745 arg1Of ",",","
R12587 T16741 T16742 arg1Of 0.4,mM
R12588 T16744 T16740 arg2Of pyruvate,","
R12589 T16744 T16741 arg1Of pyruvate,0.4
R1259 T2013 T2012 arg1Of signaling,RLR
R12590 T16744 T16743 arg1Of pyruvate,sodium
R12591 T16745 T16747 arg1Of ",",and
R12592 T16746 T16745 arg2Of antibiotics,","
R12593 T16747 T16732 arg2Of and,with
R12594 T16751 T16747 arg2Of M-CSF,and
R12595 T16751 T16748 arg1Of M-CSF,40
R12596 T16751 T16749 arg1Of M-CSF,ng/ml
R12597 T16751 T16750 arg1Of M-CSF,recombinant
R12598 T16752 T16753 arg1Of BMDM,were
R12599 T16752 T16754 arg1Of BMDM,of
R126 T192 T202 arg1Of were,as
R1260 T1915 T1937 arg1Of ligases,been
R12600 T16753 T16758 arg1Of were,as
R12601 T16754 T16753 arg2Of of,were
R12602 T16755 T16756 arg1Of ≥95,%
R12603 T16757 T16754 arg2Of purity,of
R12604 T16757 T16755 arg1Of purity,≥95
R12605 T16759 T16758 arg2Of measured,as
R12606 T16762 T16759 arg1Of cytometry,measured
R12607 T16762 T16760 arg2Of cytometry,by
R12608 T16762 T16761 arg1Of cytometry,flow
R12609 T16762 T16763 arg1Of cytometry,using
R1261 T1915 T1938 arg2Of ligases,shown
R12610 T16764 T16765 arg1Of F4/80,and
R12611 T16766 T16765 arg2Of CD11b,and
R12612 T16768 T16763 arg2Of antibodies,using
R12613 T16768 T16764 arg1Of antibodies,F4/80
R12614 T16768 T16766 arg1Of antibodies,CD11b
R12615 T16768 T16767 arg1Of antibodies,specific
R12616 T16771 T16769 arg2Of isolation,For
R12617 T16771 T16770 arg1Of isolation,the
R12618 T16771 T16772 arg1Of isolation,of
R12619 T16774 T16772 arg2Of macrophages,of
R1262 T1915 T1941 arg1Of ligases,promote
R12620 T16774 T16773 arg1Of macrophages,alveolar
R12621 T16777 T16776 arg1Of trachea,the
R12622 T16777 T16778 arg1Of trachea,was
R12623 T16777 T16779 arg2Of trachea,canulated
R12624 T16779 T16778 arg2Of canulated,was
R12625 T16779 T16780 arg1Of canulated,and
R12626 T16780 T16769 arg1Of and,For
R12627 T16780 T16775 arg1Of and,","
R12628 T16782 T16781 arg1Of lung,the
R12629 T16782 T16783 arg1Of lung,was
R1263 T2016 T2014 arg2Of removing,by
R12630 T16782 T16784 arg2Of lung,flushed
R12631 T16784 T16780 arg2Of flushed,and
R12632 T16784 T16783 arg2Of flushed,was
R12633 T16784 T16786 arg1Of flushed,times
R12634 T16786 T16785 arg1Of times,4
R12635 T16786 T16787 arg1Of times,with
R12636 T16786 T16789 arg1Of times,containing
R12637 T16788 T16787 arg2Of HBSS,with
R12638 T16790 T16791 arg1Of 1,mM
R12639 T16792 T16789 arg2Of EDTA,containing
R1264 T2016 T2015 arg1Of removing,specifically
R12640 T16792 T16790 arg1Of EDTA,1
R12641 T16794 T16793 arg1Of macrophages,Alveolar
R12642 T16794 T16795 arg1Of macrophages,were
R12643 T16794 T16796 arg2Of macrophages,cultured
R12644 T16796 T16795 arg2Of cultured,were
R12645 T16796 T16797 arg1Of cultured,in
R12646 T16798 T16797 arg2Of RPMI,in
R12647 T16798 T16799 arg1Of RPMI,1640
R12648 T16798 T16800 arg1Of RPMI,(
R12649 T16798 T16803 arg2Of RPMI,supplemented
R1265 T2016 T2020 arg1Of removing,from
R12650 T16801 T16800 arg2Of Gibco,(
R12651 T16802 T16800 arg3Of ),(
R12652 T16803 T16804 arg1Of supplemented,with
R12653 T16805 T16806 arg1Of 1,%
R12654 T16807 T16805 arg1Of FCS,1
R12655 T16807 T16808 arg1Of FCS,","
R12656 T16808 T16812 arg1Of ",",","
R12657 T16809 T16810 arg1Of 2,mM
R12658 T16811 T16808 arg2Of L-glutamine,","
R12659 T16811 T16809 arg1Of L-glutamine,2
R1266 T1917 T1916 arg2Of E3s,(
R12660 T16812 T16817 arg1Of ",",and
R12661 T16813 T16814 arg1Of 0.4,mM
R12662 T16816 T16812 arg2Of pyruvate,","
R12663 T16816 T16813 arg1Of pyruvate,0.4
R12664 T16816 T16815 arg1Of pyruvate,sodium
R12665 T16817 T16804 arg2Of and,with
R12666 T16818 T16817 arg2Of antibiotics,and
R1267 T2019 T2016 arg2Of chains,removing
R1268 T2019 T2017 arg1Of chains,K63-linked
R1269 T2019 T2018 arg1Of chains,polyubiquitin
R127 T193 T192 arg2Of hyperresponsive,were
R1270 T1918 T1916 arg3Of ),(
R1271 T2023 T2020 arg2Of molecules,from
R1272 T2023 T2021 arg1Of molecules,several
R1273 T2023 T2022 arg1Of molecules,signaling
R1274 T1921 T1920 arg1Of as,such
R1275 T2029 T2026 arg1Of ligases,various
R1276 T2029 T2027 arg1Of ligases,K48-specific
R1277 T2029 T2028 arg1Of ligases,ubiquitin
R1278 T2029 T2030 arg1Of ligases,","
R1279 T2029 T2032 arg1Of ligases,as
R128 T195 T193 arg2Of double,hyperresponsive
R1280 T2029 T2051 arg1Of ligases,","
R1281 T2029 T2053 arg1Of ligases,inhibiting
R1282 T1922 T1923 arg1Of TRIM25,[
R1283 T2032 T2031 arg1Of as,such
R1284 T2033 T2034 arg1Of AIP4,[
R1285 T2033 T2037 arg1Of AIP4,and
R1286 T1922 T1926 arg1Of TRIM25,and
R1287 T1924 T1923 arg2Of 22,[
R1288 T2035 T2034 arg2Of 32,[
R1289 T2036 T2034 arg3Of ],[
R129 T195 T194 arg1Of double,to
R1290 T2037 T2032 arg2Of and,as
R1291 T1925 T1923 arg3Of ],[
R1292 T2040 T2039 arg2Of 33,[
R1293 T1926 T1921 arg2Of and,as
R1294 T2041 T2039 arg3Of ],[
R12948 T17178 T17177 arg1Of blotting,Western
R12949 T17181 T17179 arg2Of lysates,For
R1295 T2042 T2038 arg1Of mark,TRIAD3A
R12950 T17181 T17180 arg1Of lysates,total
R12951 T17183 T17184 arg1Of cells,were
R12952 T17183 T17185 arg2Of cells,lysed
R12953 T17185 T17179 arg1Of lysed,For
R12954 T17185 T17182 arg1Of lysed,","
R12955 T17185 T17184 arg2Of lysed,were
R12956 T17185 T17186 arg1Of lysed,at
R12957 T17185 T17188 arg1Of lysed,for
R12958 T17187 T17186 arg2Of 4°C,at
R12959 T17190 T17188 arg2Of min,for
R1296 T2042 T2039 arg1Of mark,[
R12960 T17190 T17189 arg1Of min,15
R12961 T17190 T17191 arg1Of min,in
R12962 T17190 T17194 arg1Of min,(
R12963 T17190 T17217 arg2Of min,supplemented
R12964 T17193 T17191 arg2Of buffer,in
R12965 T17193 T17192 arg1Of buffer,lysis
R12966 T17197 T17195 arg1Of NaCl,200
R12967 T17197 T17196 arg1Of NaCl,mM
R12968 T17197 T17198 arg1Of NaCl,","
R12969 T17198 T17202 arg1Of ",",","
R1297 T2042 T2043 arg1Of mark,respectively
R12970 T17199 T17200 arg1Of 1,%
R12971 T17201 T17198 arg2Of NP-40,","
R12972 T17201 T17199 arg1Of NP-40,1
R12973 T17202 T17208 arg1Of ",",","
R12974 T17203 T17204 arg1Of 10,mM
R12975 T17206 T17202 arg2Of pH,","
R12976 T17206 T17203 arg1Of pH,10
R12977 T17206 T17205 arg1Of pH,Tris-HCl
R12978 T17206 T17207 arg1Of pH,7.5
R12979 T17208 T17212 arg1Of ",",","
R1298 T1927 T1926 arg2Of Riplet,and
R12980 T17209 T17210 arg1Of 5,mM
R12981 T17211 T17208 arg2Of EDTA,","
R12982 T17211 T17209 arg1Of EDTA,5
R12983 T17212 T17194 arg2Of ",",(
R12984 T17213 T17214 arg1Of 2,mM
R12985 T17215 T17212 arg2Of DTT,","
R12986 T17215 T17213 arg1Of DTT,2
R12987 T17216 T17194 arg3Of ),(
R12988 T17217 T17218 arg1Of supplemented,with
R12989 T17219 T17220 arg1Of protease,and
R1299 T1927 T1928 arg1Of Riplet,[
R12990 T17221 T17220 arg2Of phosphatase,and
R12991 T17222 T17218 arg2Of inhibitors,with
R12992 T17222 T17219 arg1Of inhibitors,protease
R12993 T17222 T17221 arg1Of inhibitors,phosphatase
R12994 T17223 T17224 arg1Of Nuclear,and
R12995 T17225 T17224 arg2Of cytoplasmic,and
R12996 T17226 T17223 arg1Of lysates,Nuclear
R12997 T17226 T17225 arg1Of lysates,cytoplasmic
R12998 T17226 T17227 arg1Of lysates,were
R12999 T17226 T17228 arg2Of lysates,prepared
R13 T82 T81 arg1Of Infection,Virus
R130 T197 T198 arg1Of RNA,and
R1300 T1929 T1928 arg2Of 23,[
R13000 T17228 T17227 arg2Of prepared,were
R13001 T17228 T17229 arg1Of prepared,by
R13002 T17228 T17273 arg1Of prepared,","
R13003 T17230 T17229 arg2Of resuspending,by
R13004 T17230 T17232 arg1Of resuspending,in
R13005 T17230 T17267 arg1Of resuspending,for
R13006 T17231 T17230 arg2Of cells,resuspending
R13007 T17233 T17232 arg2Of B1,in
R13008 T17233 T17234 arg1Of B1,(
R13009 T17237 T17235 arg1Of Hepes,10
R1301 T1930 T1928 arg3Of ],[
R13010 T17237 T17236 arg1Of Hepes,mM
R13011 T17238 T17239 arg1Of pH,7.5
R13012 T17238 T17240 arg1Of pH,","
R13013 T17240 T17244 arg1Of ",",","
R13014 T17241 T17242 arg1Of 10,mM
R13015 T17243 T17240 arg2Of KCl,","
R13016 T17243 T17241 arg1Of KCl,10
R13017 T17244 T17248 arg1Of ",",","
R13018 T17245 T17246 arg1Of 1,mM
R13019 T17247 T17244 arg2Of MgCl2,","
R1302 T2044 T2045 arg1Of MAVS,and
R13020 T17247 T17245 arg1Of MgCl2,1
R13021 T17248 T17237 arg1Of ",",Hepes
R13022 T17248 T17252 arg1Of ",",","
R13023 T17249 T17250 arg1Of 5,%
R13024 T17251 T17248 arg2Of glycerol,","
R13025 T17251 T17249 arg1Of glycerol,5
R13026 T17252 T17256 arg1Of ",",and
R13027 T17253 T17254 arg1Of 0.5,mM
R13028 T17255 T17252 arg2Of EDTA,","
R13029 T17255 T17253 arg1Of EDTA,0.5
R1303 T2045 T2037 arg2Of and,and
R13030 T17256 T17234 arg2Of and,(
R13031 T17256 T17260 arg2Of and,supplemented
R13032 T17257 T17258 arg1Of 0.1,mM
R13033 T17259 T17256 arg2Of EGTA,and
R13034 T17259 T17257 arg1Of EGTA,0.1
R13035 T17260 T17261 arg1Of supplemented,with
R13036 T17262 T17263 arg1Of protease,and
R13037 T17264 T17263 arg2Of phosphatase,and
R13038 T17265 T17261 arg2Of inhibitors,with
R13039 T17265 T17262 arg1Of inhibitors,protease
R1304 T2045 T2042 arg1Of and,mark
R13040 T17265 T17264 arg1Of inhibitors,phosphatase
R13041 T17266 T17234 arg3Of ),(
R13042 T17269 T17267 arg2Of min,for
R13043 T17269 T17268 arg1Of min,15
R13044 T17269 T17270 arg1Of min,at
R13045 T17272 T17270 arg2Of Next,at
R13046 T17272 T17271 arg1Of Next,4°C.
R13047 T17275 T17274 arg1Of detergent,NP-40
R13048 T17275 T17276 arg1Of detergent,was
R13049 T17275 T17277 arg2Of detergent,added
R1305 T2045 T2047 arg1Of and,for
R13050 T17277 T17276 arg2Of added,was
R13051 T17277 T17278 arg1Of added,to
R13052 T17277 T17285 arg1Of added,and
R13053 T17281 T17278 arg2Of concentration,to
R13054 T17281 T17279 arg1Of concentration,a
R13055 T17281 T17280 arg1Of concentration,final
R13056 T17281 T17282 arg1Of concentration,of
R13057 T17284 T17282 arg2Of %,of
R13058 T17284 T17283 arg1Of %,0.65
R13059 T17285 T17273 arg2Of and,","
R1306 T1933 T1932 arg2Of 24,[
R13060 T17286 T17287 arg1Of cells,were
R13061 T17286 T17288 arg2Of cells,centrifuged
R13062 T17288 T17285 arg2Of centrifuged,and
R13063 T17288 T17287 arg2Of centrifuged,were
R13064 T17288 T17289 arg1Of centrifuged,at
R13065 T17288 T17292 arg1Of centrifuged,for
R13066 T17291 T17289 arg2Of g,at
R13067 T17291 T17290 arg1Of g,500
R13068 T17294 T17292 arg2Of min,for
R13069 T17294 T17293 arg1Of min,5
R1307 T2046 T2045 arg2Of TRAF3,and
R13070 T17297 T17295 arg1Of fraction,The
R13071 T17297 T17296 arg1Of fraction,nuclear
R13072 T17297 T17298 arg1Of fraction,containing
R13073 T17297 T17300 arg1Of fraction,was
R13074 T17297 T17301 arg2Of fraction,lyzed
R13075 T17299 T17298 arg2Of pellet,containing
R13076 T17301 T17300 arg2Of lyzed,was
R13077 T17301 T17302 arg1Of lyzed,in
R13078 T17301 T17304 arg1Of lyzed,(
R13079 T17301 T17345 arg1Of lyzed,for
R1308 T2050 T2047 arg2Of degradation,for
R13080 T17303 T17302 arg2Of B2,in
R13081 T17307 T17305 arg1Of Hepes,20
R13082 T17307 T17306 arg1Of Hepes,mM
R13083 T17309 T17310 arg1Of 7.5,","
R13084 T17310 T17308 arg1Of ",",pH
R13085 T17312 T17310 arg2Of %,","
R13086 T17312 T17311 arg1Of %,1
R13087 T17313 T17309 arg1Of NP-40,7.5
R13088 T17313 T17312 arg1Of NP-40,%
R13089 T17313 T17314 arg1Of NP-40,","
R1309 T2050 T2048 arg1Of degradation,proteasome
R13090 T17314 T17318 arg1Of ",",","
R13091 T17315 T17316 arg1Of 400,mM
R13092 T17317 T17314 arg2Of NaCl,","
R13093 T17317 T17315 arg1Of NaCl,400
R13094 T17318 T17307 arg1Of ",",Hepes
R13095 T17318 T17322 arg1Of ",",","
R13096 T17319 T17320 arg1Of 10,mM
R13097 T17321 T17318 arg2Of KCl,","
R13098 T17321 T17319 arg1Of KCl,10
R13099 T17322 T17326 arg1Of ",",","
R131 T199 T198 arg2Of IAV,and
R1310 T2050 T2049 arg2Of degradation,mediated
R13100 T17323 T17324 arg1Of 1,mM
R13101 T17325 T17322 arg2Of MgCl2,","
R13102 T17325 T17323 arg1Of MgCl2,1
R13103 T17326 T17330 arg1Of ",",","
R13104 T17327 T17328 arg1Of 20,%
R13105 T17329 T17326 arg2Of glycerol,","
R13106 T17329 T17327 arg1Of glycerol,20
R13107 T17330 T17334 arg1Of ",",and
R13108 T17331 T17332 arg1Of 0.5,mM
R13109 T17333 T17330 arg2Of EDTA,","
R1311 T1934 T1932 arg3Of ],[
R13110 T17333 T17331 arg1Of EDTA,0.5
R13111 T17334 T17304 arg2Of and,(
R13112 T17334 T17338 arg2Of and,supplemented
R13113 T17335 T17336 arg1Of 0.1,mM
R13114 T17337 T17334 arg2Of EGTA,and
R13115 T17337 T17335 arg1Of EGTA,0.1
R13116 T17338 T17339 arg1Of supplemented,with
R13117 T17340 T17341 arg1Of protease,and
R13118 T17342 T17341 arg2Of phosphatase,and
R13119 T17343 T17339 arg2Of inhibitors,with
R1312 T2053 T2024 arg1Of inhibiting,Furthermore
R13120 T17343 T17340 arg1Of inhibitors,protease
R13121 T17343 T17342 arg1Of inhibitors,phosphatase
R13122 T17344 T17304 arg3Of ),(
R13123 T17347 T17345 arg2Of min,for
R13124 T17347 T17346 arg1Of min,15
R13125 T17347 T17348 arg1Of min,at
R13126 T17349 T17348 arg2Of 4°C.,at
R13127 T17351 T17350 arg1Of lysates,The
R13128 T17351 T17352 arg1Of lysates,were
R13129 T17351 T17354 arg2Of lysates,separated
R1313 T2053 T2025 arg1Of inhibiting,","
R13130 T17351 T17358 arg2Of lysates,analyzed
R13131 T17354 T17357 arg1Of separated,and
R13132 T17356 T17354 arg1Of SDS-PAGE,separated
R13133 T17356 T17355 arg2Of SDS-PAGE,by
R13134 T17357 T17300 modOf and,was
R13135 T17357 T17352 arg2Of and,were
R13136 T17357 T17353 arg1Of and,subsequently
R13137 T17358 T17357 arg2Of analyzed,and
R13138 T17361 T17362 arg1Of blotting,and
R13139 T17363 T17362 arg2Of ECL,and
R1314 T2053 T2052 arg1Of inhibiting,thus
R13140 T17364 T17358 arg1Of detection,analyzed
R13141 T17364 T17359 arg2Of detection,by
R13142 T17364 T17360 arg1Of detection,western
R13143 T17364 T17361 arg1Of detection,blotting
R13144 T17364 T17363 arg1Of detection,ECL
R13145 T17364 T17365 arg1Of detection,(
R13146 T17369 T17365 arg2Of Sciences,(
R13147 T17369 T17366 arg1Of Sciences,Perkin
R13148 T17369 T17367 arg1Of Sciences,Elmer
R13149 T17369 T17368 arg1Of Sciences,Life
R1315 T1938 T1935 arg1Of shown,","
R13150 T17370 T17365 arg3Of ),(
R13151 T17371 T17372 arg1Of Immunoblots,were
R13152 T17371 T17373 arg2Of Immunoblots,revealed
R13153 T17373 T17372 arg2Of revealed,were
R13154 T17373 T17374 arg1Of revealed,with
R13155 T17375 T17376 arg1Of anti-A20,","
R13156 T17376 T17378 arg1Of ",",","
R13157 T17377 T17376 arg2Of anti-IκBα,","
R13158 T17378 T17381 arg1Of ",",and
R13159 T17379 T17378 arg2Of anti-p65,","
R1316 T2056 T2053 arg2Of signaling,inhibiting
R13160 T17381 T17380 arg1Of and,","
R13161 T17382 T17381 arg2Of anti-histon,and
R13162 T17383 T17375 arg1Of H1,anti-A20
R13163 T17383 T17377 arg1Of H1,anti-IκBα
R13164 T17383 T17379 arg1Of H1,anti-p65
R13165 T17383 T17382 arg1Of H1,anti-histon
R13166 T17383 T17384 arg1Of H1,(
R13167 T17383 T17388 arg1Of H1,","
R13168 T17386 T17384 arg2Of Cruz,(
R13169 T17386 T17385 arg1Of Cruz,Santa
R1317 T2056 T2054 arg1Of signaling,further
R13170 T17387 T17384 arg3Of ),(
R13171 T17388 T17393 arg1Of ",",","
R13172 T17389 T17388 arg2Of anti-IRF3,","
R13173 T17389 T17390 arg1Of anti-IRF3,(
R13174 T17391 T17390 arg2Of Invitrogen,(
R13175 T17392 T17390 arg3Of ),(
R13176 T17393 T17374 arg2Of ",",with
R13177 T17394 T17395 arg1Of anti-phospho-IRF3,and
R13178 T17396 T17395 arg2Of anti-phospho-IκBα,and
R13179 T17399 T17394 arg1Of Signaling,anti-phospho-IRF3
R1318 T2056 T2055 arg1Of signaling,downstream
R13180 T17399 T17396 arg1Of Signaling,anti-phospho-IκBα
R13181 T17399 T17397 arg2Of Signaling,(
R13182 T17399 T17398 arg1Of Signaling,Cell
R13183 T17399 T17401 arg1Of Signaling,and
R13184 T17400 T17397 arg3Of ),(
R13185 T17401 T17393 arg2Of and,","
R13186 T17405 T17401 arg2Of Biomedicals,and
R13187 T17405 T17402 arg1Of Biomedicals,anti-actin
R13188 T17405 T17403 arg2Of Biomedicals,(
R13189 T17405 T17404 arg1Of Biomedicals,MP
R1319 T2060 T2059 arg1Of attachment,the
R13190 T17406 T17403 arg3Of ),(
R13191 T17408 T17407 arg1Of density,The
R13192 T17408 T17409 arg1Of density,of
R13193 T17408 T17412 arg1Of density,was
R13194 T17408 T17413 arg2Of density,quantified
R13195 T17411 T17409 arg2Of bands,of
R13196 T17411 T17410 arg1Of bands,the
R13197 T17413 T17412 arg2Of quantified,was
R13198 T17413 T17414 arg1Of quantified,(
R13199 T17413 T17418 arg1Of quantified,with
R132 T200 T195 arg2Of infection,double
R1320 T2060 T2061 arg1Of attachment,of
R13200 T17416 T17414 arg2Of induction,(
R13201 T17416 T17415 arg1Of induction,fold
R13202 T17417 T17414 arg3Of ),(
R13203 T17420 T17421 arg1Of ImageJ,(
R13204 T17422 T17421 arg2Of http,(
R13205 T17423 T17421 arg3Of :,(
R13206 T17424 T17420 arg1Of //rsbweb.nih.gov/ij,ImageJ
R13207 T17424 T17425 arg1Of //rsbweb.nih.gov/ij,)
R13208 T17428 T17418 arg2Of tool,with
R13209 T17428 T17419 arg1Of tool,the
R1321 T2060 T2065 arg1Of attachment,to
R13210 T17428 T17424 arg1Of tool,//rsbweb.nih.gov/ij
R13211 T17428 T17426 arg1Of tool,Gel
R13212 T17428 T17427 arg1Of tool,analyzer
R13213 T17430 T17429 arg1Of intensities,All
R13214 T17430 T17431 arg1Of intensities,were
R13215 T17430 T17432 arg2Of intensities,calculated
R13216 T17432 T17431 arg2Of calculated,were
R13217 T17432 T17434 arg1Of calculated,to
R13218 T17434 T17433 arg1Of to,relative
R13219 T17437 T17434 arg2Of lane,to
R1322 T2060 T2072 arg1Of attachment,by
R13220 T17437 T17435 arg1Of lane,the
R13221 T17437 T17436 arg1Of lane,first
R13222 T17437 T17438 arg1Of lane,(
R13223 T17440 T17438 arg2Of 0,(
R13224 T17440 T17439 arg1Of 0, = time
R13225 T17441 T17438 arg3Of ),(
R1323 T2060 T2091 arg1Of attachment,dampens
R1324 T1938 T1936 arg2Of shown,have
R1325 T2064 T2061 arg2Of chains,of
R1326 T2064 T2062 arg1Of chains,K48-specific
R1327 T2064 T2063 arg1Of chains,polyubiquitin
R1328 T1938 T1937 arg2Of shown,been
R1329 T2067 T2068 arg1Of IRF3,and
R133 T200 T196 arg1Of infection,stranded
R1330 T1941 T1938 arg3Of promote,shown
R1331 T2069 T2068 arg2Of IRF7,and
R1332 T2071 T2065 arg2Of factors,to
R1333 T2071 T2066 arg1Of factors,the
R1334 T2071 T2067 arg1Of factors,IRF3
R1335 T2071 T2069 arg1Of factors,IRF7
R1336 T2071 T2070 arg1Of factors,transcription
R1337 T2073 T2072 arg2Of E3s,by
R1338 T2073 T2075 arg1Of E3s,as
R1339 T1941 T1939 arg1Of promote,to
R134 T200 T197 arg1Of infection,RNA
R1340 T2075 T2074 arg1Of as,such
R1341 T1941 T1940 arg1Of promote,directly
R1342 T2076 T2077 arg1Of RAUL,[
R1343 T2076 T2080 arg1Of RAUL,","
R1344 T1943 T1941 arg2Of activation,promote
R1345 T2078 T2077 arg2Of 34,[
R1346 T2079 T2077 arg3Of ],[
R1347 T2080 T2085 arg1Of ",",and
R1348 T1943 T1942 arg1Of activation,RIG-I
R1349 T2081 T2080 arg2Of TRIM21,","
R135 T200 T199 arg1Of infection,IAV
R1350 T2081 T2082 arg1Of TRIM21,[
R13508 T17871 T17870 arg1Of cytometry,Flow
R13509 T17872 T17873 arg1Of Lungs,were
R1351 T1945 T1944 arg2Of addition,In
R13510 T17872 T17874 arg2Of Lungs,dissected
R13511 T17872 T17876 arg2Of Lungs,incubated
R13512 T17874 T17875 arg1Of dissected,and
R13513 T17875 T17873 arg2Of and,were
R13514 T17876 T17875 arg2Of incubated,and
R13515 T17876 T17877 arg1Of incubated,with
R13516 T17876 T17897 arg1Of incubated,for
R13517 T17879 T17878 arg1Of type,collagenase
R13518 T17879 T17880 arg1Of type,IV
R13519 T17879 T17881 arg1Of type,(
R1352 T2083 T2082 arg2Of 35,[
R13520 T17879 T17887 arg1Of type,and
R13521 T17883 T17881 arg2Of mg/ml,(
R13522 T17883 T17882 arg1Of mg/ml,1
R13523 T17883 T17884 arg1Of mg/ml,;
R13524 T17885 T17884 arg2Of Sigma,;
R13525 T17886 T17881 arg3Of ),(
R13526 T17887 T17877 arg2Of and,with
R13527 T17888 T17887 arg2Of DNAse,and
R13528 T17888 T17889 arg1Of DNAse,(
R13529 T17888 T17895 arg1Of DNAse,at
R1353 T2084 T2082 arg3Of ],[
R13530 T17891 T17889 arg2Of U/ml,(
R13531 T17891 T17890 arg1Of U/ml,100
R13532 T17891 T17892 arg1Of U/ml,;
R13533 T17893 T17892 arg2Of Roche,;
R13534 T17894 T17889 arg3Of ),(
R13535 T17896 T17895 arg2Of 37°C,at
R13536 T17899 T17897 arg2Of min,for
R13537 T17899 T17898 arg1Of min,30
R13538 T17902 T17903 arg1Of samples,were
R13539 T17902 T17904 arg2Of samples,filtered
R1354 T2085 T2075 arg2Of and,as
R13540 T17904 T17900 arg1Of filtered,Subsequently
R13541 T17904 T17901 arg1Of filtered,","
R13542 T17904 T17903 arg2Of filtered,were
R13543 T17904 T17905 arg1Of filtered,through
R13544 T17908 T17909 arg1Of µm,and
R13545 T17909 T17907 arg1Of and,70
R13546 T17910 T17909 arg2Of 40,and
R13547 T17913 T17905 arg2Of mesh,through
R13548 T17913 T17906 arg1Of mesh,a
R13549 T17913 T17908 arg1Of mesh,µm
R1355 T2142 T2141 arg2Of response,in
R13550 T17913 T17910 arg1Of mesh,40
R13551 T17913 T17911 arg1Of mesh,µm
R13552 T17913 T17912 arg1Of mesh,nylon
R13553 T17916 T17914 arg2Of preparation,For
R13554 T17916 T17915 arg1Of preparation,the
R13555 T17916 T17917 arg1Of preparation,of
R13556 T17918 T17917 arg2Of BAL,of
R13557 T17920 T17921 arg1Of trachea,were
R13558 T17920 T17922 arg2Of trachea,canulated
R13559 T17922 T17921 arg2Of canulated,were
R1356 T2086 T2085 arg2Of RBCK1,and
R13560 T17922 T17923 arg1Of canulated,and
R13561 T17923 T17914 arg1Of and,For
R13562 T17923 T17919 arg1Of and,","
R13563 T17925 T17924 arg1Of lumen,airway
R13564 T17925 T17926 arg1Of lumen,was
R13565 T17925 T17927 arg2Of lumen,flushed
R13566 T17927 T17923 arg2Of flushed,and
R13567 T17927 T17926 arg2Of flushed,was
R13568 T17927 T17929 arg1Of flushed,times
R13569 T17927 T17930 arg1Of flushed,with
R1357 T2086 T2087 arg1Of RBCK1,[
R13570 T17929 T17928 arg1Of times,4
R13571 T17931 T17930 arg2Of HBSS,with
R13572 T17931 T17932 arg1Of HBSS,with
R13573 T17933 T17934 arg1Of 1,mM
R13574 T17935 T17932 arg2Of EDTA,with
R13575 T17935 T17933 arg1Of EDTA,1
R13576 T17937 T17936 arg1Of iodide,Propidium
R13577 T17937 T17938 arg1Of iodide,was
R13578 T17937 T17939 arg2Of iodide,used
R13579 T17939 T17938 arg2Of used,was
R1358 T2088 T2087 arg2Of 36,[
R13580 T17941 T17939 arg3Of discriminate,used
R13581 T17941 T17940 arg1Of discriminate,to
R13582 T17941 T17942 arg1Of discriminate,between
R13583 T17943 T17944 arg1Of live,and
R13584 T17945 T17944 arg2Of dead,and
R13585 T17946 T17942 arg2Of cells,between
R13586 T17946 T17943 arg1Of cells,live
R13587 T17946 T17945 arg1Of cells,dead
R1359 T2089 T2087 arg3Of ],[
R136 T203 T202 arg2Of illustrated,as
R1360 T2091 T2057 arg1Of dampens,Additionally
R1361 T2091 T2058 arg1Of dampens,","
R1362 T2091 T2090 arg1Of dampens,further
R1363 T2142 T2143 arg1Of response,to
R1364 T2145 T2143 arg2Of receptors,to
R1365 T2094 T2091 arg2Of transduction,dampens
R1366 T2094 T2092 arg1Of transduction,antiviral
R1367 T2094 T2093 arg1Of transduction,signal
R1368 T2095 T2096 arg1Of A20,is
R1369 T2145 T2144 arg1Of receptors,multiple
R137 T206 T205 arg2Of NF-κB,enhanced
R1370 T2099 T2096 arg2Of enzyme,is
R1371 T2099 T2097 arg1Of enzyme,an
R1372 T2099 T2098 arg1Of enzyme,ubiquitin-editing
R1373 T2099 T2100 arg1Of enzyme,belonging
R1374 T2100 T2101 arg1Of belonging,to
R1375 T2145 T2147 arg1Of receptors,as
R1376 T2104 T2101 arg2Of family,to
R1377 T2147 T2146 arg1Of as,such
R1378 T2104 T2102 arg1Of family,the
R13786 T18306 T18305 arg1Of quantification,Cytokine
R13787 T18309 T18307 arg2Of ELISA,For
R13788 T18309 T18308 arg1Of ELISA,TNF
R13789 T18312 T18311 arg1Of plates,96-well
R1379 T2104 T2103 arg1Of family,OTU-domain
R13790 T18312 T18313 arg1Of plates,were
R13791 T18312 T18314 arg2Of plates,coated
R13792 T18314 T18307 arg1Of coated,For
R13793 T18314 T18310 arg1Of coated,","
R13794 T18314 T18313 arg2Of coated,were
R13795 T18314 T18315 arg1Of coated,with
R13796 T18317 T18316 arg1Of coating,TNF
R13797 T18317 T18318 arg1Of coating,(
R13798 T18317 T18323 arg1Of coating,and
R13799 T18319 T18318 arg2Of TN3-19,(
R138 T206 T207 arg1Of NF-κB,and
R1380 T2104 T2105 arg1Of family,of
R13800 T18319 T18320 arg1Of TN3-19,","
R13801 T18321 T18320 arg2Of eBioscience,","
R13802 T18322 T18318 arg3Of ),(
R13803 T18323 T18315 arg2Of and,with
R13804 T18324 T18325 arg1Of detection,(
R13805 T18326 T18325 arg2Of R4-6A2,(
R13806 T18326 T18327 arg1Of R4-6A2,","
R13807 T18328 T18327 arg2Of eBioscience,","
R13808 T18329 T18325 arg3Of ),(
R13809 T18330 T18323 arg2Of antibodies,and
R1381 T2106 T2105 arg2Of DUBs,of
R13810 T18330 T18324 arg1Of antibodies,detection
R13811 T18331 T18332 arg1Of IFNα,and
R13812 T18333 T18332 arg2Of IFNβ,and
R13813 T18335 T18331 arg1Of levels,IFNα
R13814 T18335 T18333 arg1Of levels,IFNβ
R13815 T18335 T18334 arg1Of levels,protein
R13816 T18335 T18336 arg1Of levels,were
R13817 T18335 T18337 arg2Of levels,determined
R13818 T18337 T18336 arg2Of determined,were
R13819 T18337 T18338 arg1Of determined,with
R1382 T2149 T2148 arg1Of receptor,TNF
R13820 T18341 T18338 arg2Of kit,with
R13821 T18341 T18339 arg1Of kit,an
R13822 T18341 T18340 arg1Of kit,ELISA
R13823 T18341 T18342 arg1Of kit,(
R13824 T18345 T18342 arg2Of Laboratories,(
R13825 T18345 T18343 arg1Of Laboratories,PBL
R13826 T18345 T18344 arg1Of Laboratories,Biomedical
R13827 T18346 T18342 arg3Of ),(
R13828 T18349 T18347 arg2Of ELISA,For
R13829 T18349 T18348 arg1Of ELISA,IFNγ
R1383 T2149 T2150 arg1Of receptor,I
R13830 T18352 T18351 arg1Of plates,96-well
R13831 T18352 T18353 arg1Of plates,were
R13832 T18352 T18354 arg2Of plates,coated
R13833 T18354 T18347 arg1Of coated,For
R13834 T18354 T18350 arg1Of coated,","
R13835 T18354 T18353 arg2Of coated,were
R13836 T18354 T18355 arg1Of coated,with
R13837 T18357 T18356 arg1Of coating,IFNγ
R13838 T18357 T18358 arg1Of coating,(
R13839 T18357 T18361 arg1Of coating,and
R1384 T2152 T2151 arg2Of 37,[
R13840 T18359 T18358 arg2Of XMG1.2,(
R13841 T18360 T18358 arg3Of ),(
R13842 T18361 T18355 arg2Of and,with
R13843 T18364 T18363 arg2Of R4-6A2,(
R13844 T18365 T18363 arg3Of ),(
R13845 T18366 T18361 arg2Of antibodies,and
R13846 T18366 T18362 arg1Of antibodies,detection
R13847 T18366 T18363 arg1Of antibodies,(
R13848 T18366 T18367 arg1Of antibodies,(
R13849 T18368 T18367 arg2Of eBiosciences,(
R1385 T2109 T2111 arg1Of A20,harbors
R13850 T18369 T18367 arg3Of ),(
R13851 T18370 T18371 arg1Of Detection,of
R13852 T18370 T18384 arg1Of Detection,was
R13853 T18370 T18385 arg2Of Detection,performed
R13854 T18372 T18373 arg1Of MCP-1,","
R13855 T18373 T18375 arg1Of ",",","
R13856 T18374 T18373 arg2Of KC,","
R13857 T18375 T18377 arg1Of ",",","
R13858 T18376 T18375 arg2Of TNF,","
R13859 T18377 T18379 arg1Of ",",and
R1386 T2111 T2107 arg1Of harbors,Interestingly
R13860 T18378 T18377 arg2Of IL-1β,","
R13861 T18379 T18371 arg2Of and,of
R13862 T18379 T18381 arg1Of and,in
R13863 T18380 T18379 arg2Of IL-6,and
R13864 T18383 T18381 arg2Of fluid,in
R13865 T18383 T18382 arg1Of fluid,BAL
R13866 T18385 T18384 arg2Of performed,was
R13867 T18386 T18385 arg3Of using,performed
R13868 T18386 T18392 arg1Of using,according
R13869 T18389 T18388 arg2Of BioRad,(
R1387 T2111 T2108 arg1Of harbors,","
R13870 T18390 T18388 arg3Of ),(
R13871 T18391 T18386 arg2Of technology,using
R13872 T18391 T18387 arg1Of technology,Bioplex
R13873 T18391 T18388 arg1Of technology,(
R13874 T18393 T18392 arg2Of to,according
R13875 T18395 T18394 arg1Of manufacturer,the
R13876 T18395 T18396 arg2Of manufacturer,'s
R13877 T18397 T18393 arg2Of instructions,to
R13878 T18397 T18396 arg1Of instructions,'s
R13879 T18399 T18398 arg1Of technology,Milliplex
R1388 T2111 T2110 arg1Of harbors,also
R13880 T18399 T18400 arg1Of technology,(
R13881 T18399 T18403 arg1Of technology,was
R13882 T18399 T18404 arg2Of technology,used
R13883 T18401 T18400 arg2Of Millipore,(
R13884 T18402 T18400 arg3Of ),(
R13885 T18404 T18403 arg2Of used,was
R13886 T18404 T18405 arg1Of used,for
R13887 T18407 T18405 arg2Of detection,for
R13888 T18407 T18406 arg1Of detection,the
R13889 T18407 T18408 arg1Of detection,of
R1389 T2153 T2151 arg3Of ],[
R13890 T18407 T18410 arg1Of detection,in
R13891 T18409 T18408 arg2Of MIP-2,of
R13892 T18412 T18410 arg2Of fluid,in
R13893 T18412 T18411 arg1Of fluid,BAL
R139 T207 T203 arg1Of and,illustrated
R1390 T2154 T2149 arg1Of –,receptor
R1391 T2154 T2151 arg1Of –,[
R1392 T2154 T2155 arg1Of –,[
R1393 T2120 T2111 arg2Of activity,harbors
R1394 T2120 T2112 arg1Of activity,atypical
R1395 T2120 T2113 arg1Of activity,zinc
R1396 T2120 T2114 arg1Of activity,finger
R1397 T2120 T2115 arg1Of activity,dependent
R1398 T2120 T2116 arg1Of activity,K48-specific
R1399 T2120 T2117 arg1Of activity,E3
R14 T86 T83 arg1Of response,The
R140 T207 T204 arg2Of and,by
R1400 T2120 T2118 arg1Of activity,ubiquitin
R1401 T2120 T2119 arg1Of activity,ligase
R14018 T18696 T18695 arg1Of isolation,RNA
R14019 T18696 T18697 arg1Of isolation,","
R1402 T2154 T2158 arg1Of –,","
R14020 T18697 T18700 arg1Of ",",and
R14021 T18699 T18697 arg2Of synthesis,","
R14022 T18699 T18698 arg1Of synthesis,cDNA
R14023 T18701 T18700 arg2Of qPCR,and
R14024 T18703 T18702 arg1Of RNA,Total
R14025 T18703 T18704 arg1Of RNA,was
R14026 T18703 T18705 arg2Of RNA,extracted
R14027 T18705 T18704 arg2Of extracted,was
R14028 T18705 T18706 modOf extracted,using
R14029 T18705 T18715 arg1Of extracted,and
R1403 T2156 T2155 arg2Of 39,[
R14030 T18708 T18707 arg1Of Total,Aurum
R14031 T18711 T18706 arg2Of kit,using
R14032 T18711 T18708 arg1Of kit,Total
R14033 T18711 T18709 arg1Of kit,RNA
R14034 T18711 T18710 arg1Of kit,mini
R14035 T18711 T18712 arg1Of kit,(
R14036 T18713 T18712 arg2Of BioRad,(
R14037 T18714 T18712 arg3Of ),(
R14038 T18716 T18717 arg2Of reverse,transcribed
R14039 T18716 T18735 arg1Of reverse,was
R1404 T2122 T2123 arg1Of catalytic,and
R14040 T18716 T18736 arg2Of reverse,performed
R14041 T18717 T18718 arg1Of transcribed,into
R14042 T18717 T18720 arg1Of transcribed,with
R14043 T18717 T18728 arg1Of transcribed,according
R14044 T18719 T18718 arg2Of cDNA,into
R14045 T18724 T18720 arg2Of kit,with
R14046 T18724 T18721 arg1Of kit,iScript
R14047 T18724 T18722 arg1Of kit,cDNA
R14048 T18724 T18723 arg1Of kit,synthesis
R14049 T18724 T18725 arg1Of kit,(
R1405 T2124 T2123 arg2Of noncatalytic,and
R14050 T18726 T18725 arg2Of BioRad,(
R14051 T18727 T18725 arg3Of ),(
R14052 T18729 T18728 arg2Of to,according
R14053 T18731 T18730 arg1Of manufacturer,the
R14054 T18731 T18732 arg2Of manufacturer,'s
R14055 T18734 T18729 arg2Of qPCR,to
R14056 T18734 T18732 arg1Of qPCR,'s
R14057 T18734 T18733 arg1Of qPCR,instructions.
R14058 T18736 T18715 arg2Of performed,and
R14059 T18736 T18735 arg2Of performed,was
R1406 T2125 T2121 arg1Of mechanisms,Both
R14060 T18736 T18737 arg1Of performed,by
R14061 T18736 T18763 arg1Of performed,:
R14062 T18738 T18737 arg2Of using,by
R14063 T18741 T18739 arg1Of I,SYBR
R14064 T18741 T18740 arg1Of I,Green
R14065 T18743 T18738 arg2Of mix,using
R14066 T18743 T18741 arg1Of mix,I
R14067 T18743 T18742 arg1Of mix,master
R14068 T18743 T18744 arg1Of mix,I
R14069 T18743 T18745 arg1Of mix,(
R1407 T2125 T2122 arg1Of mechanisms,catalytic
R14070 T18743 T18748 arg1Of mix,in
R14071 T18743 T18761 arg1Of mix,:
R14072 T18746 T18745 arg2Of Roche,(
R14073 T18747 T18745 arg3Of ),(
R14074 T18750 T18751 arg1Of Lightcycler,480
R14075 T18753 T18748 arg2Of system,in
R14076 T18753 T18749 arg1Of system,the
R14077 T18753 T18750 arg1Of system,Lightcycler
R14078 T18753 T18752 arg1Of system,detection
R14079 T18753 T18754 arg1Of system,(
R1408 T2125 T2124 arg1Of mechanisms,noncatalytic
R14080 T18753 T18757 arg1Of system,with
R14081 T18755 T18754 arg2Of Roche,(
R14082 T18756 T18754 arg3Of ),(
R14083 T18760 T18757 arg2Of primers,with
R14084 T18760 T18758 arg1Of primers,the
R14085 T18760 T18759 arg1Of primers,following
R14086 T18762 T18761 arg2Of HPRT,:
R14087 T18764 T18765 arg1Of 5′-AGTGTTGGATACAGGCCAGAC-3′,and
R14088 T18765 T18767 arg1Of and,;
R14089 T18766 T18765 arg2Of 5′CGTGATTCAAATCCCTGAAGT-3′,and
R1409 T2125 T2126 arg1Of mechanisms,were
R14090 T18768 T18767 arg2Of IL-6,;
R14091 T18768 T18769 arg1Of IL-6,:
R14092 T18770 T18771 arg1Of 5′-GAGGATACCACTCCCAACAGACC-3′,and
R14093 T18771 T18773 arg1Of and,;
R14094 T18772 T18771 arg2Of 5′-AAGTGCATCATCGTTGTTCATACA-3′,and
R14095 T18774 T18773 arg2Of IFNβ,;
R14096 T18774 T18775 arg1Of IFNβ,:
R14097 T18776 T18777 arg1Of 5′-TCAGAATGAGTGGTGGTTGC-3′,and
R14098 T18777 T18779 arg1Of and,;
R14099 T18778 T18777 arg2Of 5′-GACCTTTCAAATGCAGTAGATTCA-3′,and
R141 T207 T210 arg1Of and,","
R1410 T2125 T2128 arg2Of mechanisms,shown
R14100 T18780 T18779 arg2Of A20,;
R14101 T18780 T18781 arg1Of A20,:
R14102 T18782 T18783 arg1Of 5′-AAACCAATGGTGATGGAAACTG-3′,and
R14103 T18783 T18785 arg1Of and,;
R14104 T18784 T18783 arg2Of 5′-GTTGTCCCATTCGTCATTCC-3′,and
R14105 T18786 T18785 arg2Of CCL2,;
R14106 T18786 T18787 arg1Of CCL2,:
R14107 T18788 T18789 arg1Of 5′-TTAAAAACCTGGATCGGAACCAA-3′,and
R14108 T18789 T18791 arg1Of and,;
R14109 T18790 T18789 arg2Of 5′-GCATTAGCTTCAGATTTACGGGT-3′,and
R1411 T2125 T2130 arg1Of mechanisms,be
R14110 T18792 T18791 arg2Of CXCL1,;
R14111 T18792 T18793 arg1Of CXCL1,:
R14112 T18794 T18795 arg1Of 5′-GAGCCTCTAACCAGTTCCAG-3′,and
R14113 T18795 T18799 arg1Of and,:
R14114 T18796 T18797 arg1Of 5′-TGAGTGTGGCTATGACTTCG-3′,and
R14115 T18797 T18795 arg2Of and,and
R14116 T18798 T18797 arg2Of IFNα4,and
R14117 T18800 T18801 arg1Of 5′-TGATGAGCTACTACTGGTCAGC-3′,and
R14118 T18802 T18801 arg2Of 5′-GATCTCTTAGCACAAGGATGGC-3′,and
R14119 T18803 T18804 arg1Of Primers,were
R1412 T2125 T2131 arg2Of mechanisms,involved
R14120 T18803 T18805 arg2Of Primers,designed
R14121 T18805 T18804 arg2Of designed,were
R14122 T18805 T18806 arg1Of designed,with
R14123 T18807 T18806 arg2Of PerlPrimer,with
R14124 T18807 T18809 arg1Of PerlPrimer,http
R14125 T18807 T18811 arg1Of PerlPrimer,//perlprimer.sourceforge.net
R14126 T18807 T18812 arg1Of PerlPrimer,)
R14127 T18809 T18810 arg1Of http,:
R14128 T18810 T18808 arg1Of :,(
R14129 T18811 T18810 arg2Of //perlprimer.sourceforge.net,:
R1413 T2157 T2155 arg3Of ],[
R14130 T18813 T18814 arg1Of Quantification,was
R14131 T18813 T18815 arg2Of Quantification,performed
R14132 T18815 T18814 arg2Of performed,was
R14133 T18816 T18815 arg3Of using,performed
R14134 T18820 T18816 arg2Of method,using
R14135 T18820 T18817 arg1Of method,the
R14136 T18820 T18818 arg1Of method,comparative
R14137 T18820 T18819 arg1Of method,CT
R14138 T18820 T18821 arg1Of method,(
R14139 T18822 T18821 arg2Of ΔΔCT,(
R1414 T2128 T2126 arg2Of shown,were
R14140 T18823 T18821 arg3Of ),(
R14141 T18824 T18825 arg1Of Results,are
R14142 T18824 T18826 arg2Of Results,expressed
R14143 T18826 T18825 arg2Of expressed,are
R14144 T18826 T18828 arg1Of expressed,to
R14145 T18828 T18827 arg1Of to,relative
R14146 T18830 T18828 arg2Of values,to
R14147 T18830 T18829 arg1Of values,HPRT
R1415 T2128 T2127 arg1Of shown,previously
R1416 T2158 T2164 arg1Of ",",and
R1417 T2131 T2128 arg3Of involved,shown
R1418 T2131 T2129 arg1Of involved,to
R1419 T2131 T2130 arg2Of involved,be
R142 T207 T211 arg1Of and,concomitant
R1420 T2131 T2132 arg1Of involved,in
R1421 T2131 T2141 arg1Of involved,in
R1422 T2159 T2158 arg2Of TLR4,","
R1423 T2135 T2132 arg2Of regulation,in
R1424 T2135 T2133 arg1Of regulation,the
R1425 T2135 T2134 arg1Of regulation,negative
R1426 T2135 T2136 arg1Of regulation,of
R1427 T2135 T2139 arg1Of regulation,by
R1428 T2138 T2136 arg2Of signaling,of
R1429 T2138 T2137 arg1Of signaling,proinflammatory
R143 T209 T207 arg2Of activation,and
R1430 T2140 T2139 arg2Of A20,by
R1431 T2159 T2160 arg1Of TLR4,[
R1432 T2161 T2160 arg2Of 40,[
R1433 T2162 T2160 arg3Of ],[
R1434 T2164 T2147 arg2Of and,as
R14349 T19108 T19109 arg1Of Results,are
R1435 T2238 T2235 arg2Of response,on
R14350 T19108 T19110 arg2Of Results,expressed
R14351 T19110 T19109 arg2Of expressed,are
R14352 T19110 T19111 arg1Of expressed,as
R14353 T19115 T19111 arg2Of SEM,as
R14354 T19115 T19112 arg1Of SEM,the
R14355 T19115 T19113 arg1Of SEM,mean
R14356 T19115 T19114 arg1Of SEM,±
R14357 T19117 T19116 arg1Of significance,Statistical
R14358 T19117 T19118 arg1Of significance,between
R14359 T19117 T19120 arg1Of significance,was
R1436 T2238 T2236 arg1Of response,the
R14360 T19117 T19121 arg2Of significance,assessed
R14361 T19119 T19118 arg2Of groups,between
R14362 T19121 T19120 arg2Of assessed,was
R14363 T19122 T19121 arg3Of using,assessed
R14364 T19124 T19122 arg2Of ANOVA,using
R14365 T19124 T19123 arg1Of ANOVA,two-way
R14366 T19126 T19125 arg1Of differences,The
R14367 T19126 T19127 arg1Of differences,for
R14368 T19126 T19139 arg1Of differences,were
R14369 T19126 T19140 arg2Of differences,calculated
R1437 T2238 T2237 arg1Of response,inflammatory
R14370 T19129 T19128 arg1Of vivo,in
R14371 T19130 T19127 arg2Of experiments,for
R14372 T19130 T19129 arg1Of experiments,vivo
R14373 T19130 T19131 arg1Of experiments,(
R14374 T19134 T19132 arg1Of 5,at
R14375 T19134 T19133 arg1Of 5,least
R14376 T19135 T19131 arg2Of mice,(
R14377 T19135 T19134 arg1Of mice,5
R14378 T19135 T19136 arg1Of mice,per
R14379 T19137 T19136 arg2Of group,per
R1438 T2164 T2163 arg1Of and,","
R14380 T19138 T19131 arg3Of ),(
R14381 T19140 T19139 arg2Of calculated,were
R14382 T19140 T19141 modOf calculated,using
R14383 T19141 T19145 arg1Of using,for
R14384 T19144 T19141 arg2Of U-test,using
R14385 T19144 T19142 arg1Of U-test,the
R14386 T19144 T19143 arg1Of U-test,Mann-Whitney
R14387 T19147 T19145 arg2Of data,for
R14388 T19147 T19146 arg1Of data,unpaired
R14389 T19149 T19148 arg1Of significance,Statistical
R1439 T2240 T2239 arg1Of relevance,The
R14390 T19149 T19150 arg1Of significance,of
R14391 T19149 T19152 arg1Of significance,between
R14392 T19149 T19155 arg1Of significance,was
R14393 T19149 T19156 arg2Of significance,analyzed
R14394 T19151 T19150 arg2Of differences,of
R14395 T19154 T19152 arg2Of rates,between
R14396 T19154 T19153 arg1Of rates,survival
R14397 T19156 T19155 arg2Of analyzed,was
R14398 T19156 T19157 arg1Of analyzed,by
R14399 T19158 T19157 arg2Of comparing,by
R144 T209 T208 arg1Of activation,IRF3
R1440 T2240 T2241 arg1Of relevance,of
R14400 T19160 T19158 arg2Of curves,comparing
R14401 T19160 T19159 arg1Of curves,Kaplan-Meier
R14402 T19160 T19161 arg1Of curves,using
R14403 T19164 T19161 arg2Of test,using
R14404 T19164 T19162 arg1Of test,the
R14405 T19164 T19163 arg1Of test,log-rank
R14406 T19164 T19165 arg1Of test,(
R14407 T19167 T19166 arg1Of Prism,GraphPad
R14408 T19168 T19165 arg2Of version,(
R14409 T19168 T19167 arg1Of version,Prism
R1441 T2240 T2244 arg1Of relevance,for
R14410 T19168 T19169 arg1Of version,5
R14411 T19168 T19170 arg1Of version,","
R14412 T19171 T19170 arg2Of GraphPad,","
R14413 T19171 T19172 arg1Of GraphPad,","
R14414 T19174 T19172 arg2Of Diego,","
R14415 T19174 T19173 arg1Of Diego,San
R14416 T19174 T19175 arg1Of Diego,","
R14417 T19176 T19175 arg2Of CA,","
R14418 T19177 T19165 arg3Of ),(
R1442 T2240 T2247 arg1Of relevance,has
R1443 T2240 T2249 arg1Of relevance,been
R1444 T2240 T2250 arg2Of relevance,illustrated
R1445 T2165 T2164 arg2Of IL-1R,and
R1446 T2243 T2241 arg2Of findings,of
R1447 T2243 T2242 arg1Of findings,these
R1448 T2165 T2166 arg1Of IL-1R,[
R1449 T2246 T2244 arg2Of disease,for
R145 T211 T212 arg1Of concomitant,with
R1450 T2246 T2245 arg1Of disease,human
R1451 T2167 T2166 arg2Of 41,[
R1452 T2168 T2166 arg3Of ],[
R14529 T19463 T19464 arg1Of A20,inhibits
R1453 T2250 T2247 arg2Of illustrated,has
R14530 T19465 T19466 arg1Of NF-κB,and
R14531 T19467 T19466 arg2Of IRF3,and
R14532 T19468 T19464 arg2Of activation,inhibits
R14533 T19468 T19465 arg1Of activation,NF-κB
R14534 T19468 T19467 arg1Of activation,IRF3
R14535 T19468 T19469 arg1Of activation,in
R14536 T19469 T19471 arg1Of in,to
R14537 T19470 T19469 arg2Of response,in
R14538 T19473 T19469 arg3Of stimulation,in
R14539 T19473 T19472 arg1Of stimulation,RIG-I
R1454 T2250 T2248 arg1Of illustrated,recently
R14540 T19475 T19474 arg2Of A,(
R14541 T19476 T19474 arg3Of ),(
R14542 T19478 T19474 arg1Of cells,(
R14543 T19478 T19477 arg1Of cells,HEK293T
R14544 T19478 T19479 arg1Of cells,were
R14545 T19478 T19480 arg2Of cells,transfected
R14546 T19480 T19479 arg2Of transfected,were
R14547 T19480 T19481 arg1Of transfected,with
R14548 T19482 T19483 arg1Of NF-κB,(
R14549 T19482 T19486 arg1Of NF-κB,","
R1455 T2250 T2249 arg2Of illustrated,been
R14550 T19484 T19483 arg2Of left,(
R14551 T19485 T19483 arg3Of ),(
R14552 T19486 T19491 arg1Of ",",or
R14553 T19487 T19486 arg2Of IRF3,","
R14554 T19487 T19488 arg1Of IRF3,(
R14555 T19489 T19488 arg2Of middle,(
R14556 T19490 T19488 arg3Of ),(
R14557 T19491 T19509 arg1Of or,","
R14558 T19495 T19492 arg1Of reporter,IRF7
R14559 T19495 T19493 arg1Of reporter,dependent
R1456 T2250 T2251 arg1Of illustrated,through
R14560 T19495 T19494 arg1Of reporter,luciferase
R14561 T19495 T19496 arg1Of reporter,(
R14562 T19497 T19496 arg2Of right,(
R14563 T19498 T19496 arg3Of ),(
R14564 T19499 T19491 arg2Of plasmids,or
R14565 T19499 T19495 arg1Of plasmids,reporter
R14566 T19499 T19500 arg1Of plasmids,","
R14567 T19499 T19502 arg1Of plasmids,with
R14568 T19502 T19501 arg1Of with,together
R14569 T19503 T19502 arg2Of plasmids,with
R1457 T2171 T2169 arg1Of role,The
R14570 T19503 T19504 arg1Of plasmids,expressing
R14571 T19505 T19504 arg2Of RIG-I,expressing
R14572 T19505 T19506 arg1Of RIG-I,(
R14573 T19507 T19506 arg2Of 2CARD,(
R14574 T19508 T19506 arg3Of ),(
R14575 T19509 T19514 arg1Of ",",and
R14576 T19510 T19509 arg2Of IRF7,","
R14577 T19510 T19511 arg1Of IRF7,(
R14578 T19512 T19511 arg2Of right,(
R14579 T19513 T19511 arg3Of ),(
R1458 T2253 T2251 arg2Of identification,through
R14580 T19514 T19481 arg2Of and,with
R14581 T19516 T19514 arg2Of amounts,and
R14582 T19516 T19515 arg1Of amounts,increasing
R14583 T19516 T19517 arg1Of amounts,of
R14584 T19518 T19517 arg2Of A20,of
R14585 T19520 T19519 arg1Of activity,Luciferase
R14586 T19520 T19521 arg1Of activity,in
R14587 T19520 T19524 arg1Of activity,was
R14588 T19520 T19525 arg2Of activity,analyzed
R14589 T19523 T19521 arg2Of extracts,in
R1459 T2253 T2252 arg1Of identification,the
R14590 T19523 T19522 arg1Of extracts,cell
R14591 T19525 T19524 arg2Of analyzed,was
R14592 T19525 T19526 arg1Of analyzed,in
R14593 T19528 T19526 arg2Of luminometer,in
R14594 T19528 T19527 arg1Of luminometer,a
R14595 T19529 T19530 arg1Of Numbers,are
R14596 T19531 T19532 arg1Of averages,+/−
R14597 T19532 T19530 arg2Of +/−,are
R14598 T19533 T19532 arg2Of SD,+/−
R14599 T19533 T19534 arg1Of SD,of
R146 T214 T212 arg2Of production,with
R1460 T2253 T2254 arg1Of identification,of
R14600 T19533 T19550 modOf SD,were
R14601 T19536 T19534 arg2Of samples,of
R14602 T19536 T19535 arg1Of samples,3
R14603 T19536 T19537 arg1Of samples,per
R14604 T19538 T19537 arg2Of set-up.,per
R14605 T19540 T19539 arg2Of B–D,(
R14606 T19541 T19539 arg3Of ),(
R14607 T19542 T19543 arg1Of A20myel-KO,and
R14608 T19544 T19543 arg2Of wild,and
R14609 T19547 T19546 arg2Of A20myel-WT,(
R1461 T2171 T2170 arg1Of role,anti-inflammatory
R14610 T19548 T19546 arg3Of ),(
R14611 T19549 T19539 arg1Of BMDM,(
R14612 T19549 T19542 arg1Of BMDM,A20myel-KO
R14613 T19549 T19544 arg1Of BMDM,wild
R14614 T19549 T19545 arg1Of BMDM,type
R14615 T19549 T19546 arg1Of BMDM,(
R14616 T19549 T19550 arg1Of BMDM,were
R14617 T19549 T19551 arg2Of BMDM,transfected
R14618 T19549 T19561 arg2Of BMDM,analyzed
R14619 T19551 T19552 arg1Of transfected,with
R1462 T2255 T2254 arg2Of polymorphisms,of
R14620 T19551 T19560 arg1Of transfected,and
R14621 T19554 T19552 arg2Of poly,with
R14622 T19554 T19553 arg1Of poly,LMW
R14623 T19554 T19555 arg1Of poly,(
R14624 T19558 T19555 arg2Of C,(
R14625 T19558 T19556 arg1Of C,I
R14626 T19558 T19557 arg1Of C,:
R14627 T19559 T19555 arg3Of ),(
R14628 T19560 T19550 arg2Of and,were
R14629 T19561 T19560 arg2Of analyzed,and
R1463 T2255 T2256 arg1Of polymorphisms,in
R14630 T19561 T19562 arg1Of analyzed,at
R14631 T19561 T19569 arg1Of analyzed,after
R14632 T19565 T19562 arg2Of points,at
R14633 T19565 T19563 arg1Of points,different
R14634 T19565 T19564 arg1Of points,time
R14635 T19565 T19566 arg1Of points,(
R14636 T19567 T19566 arg2Of minutes,(
R14637 T19568 T19566 arg3Of ),(
R14638 T19571 T19569 arg2Of start,after
R14639 T19571 T19570 arg1Of start,the
R1464 T2255 T2260 arg1Of polymorphisms,that
R14640 T19571 T19572 arg1Of start,of
R14641 T19573 T19574 arg1Of transfection,for
R14642 T19573 T19580 arg1Of transfection,and
R14643 T19576 T19577 arg1Of phosphorylation,and
R14644 T19577 T19574 arg2Of and,for
R14645 T19577 T19575 arg1Of and,IκBα
R14646 T19578 T19577 arg2Of degradation,and
R14647 T19580 T19572 arg2Of and,of
R14648 T19580 T19579 arg1Of and,","
R14649 T19580 T19583 arg1Of and,by
R1465 T2255 T2261 arg1Of polymorphisms,are
R14650 T19582 T19580 arg2Of phosphorylation,and
R14651 T19582 T19581 arg1Of phosphorylation,IRF3
R14652 T19584 T19583 arg2Of immunoblotting,by
R14653 T19584 T19585 arg1Of immunoblotting,of
R14654 T19588 T19585 arg2Of extracts,of
R14655 T19588 T19586 arg1Of extracts,total
R14656 T19588 T19587 arg1Of extracts,cell
R14657 T19588 T19589 arg1Of extracts,(
R14658 T19590 T19589 arg2Of B,(
R14659 T19591 T19589 arg3Of ),(
R1466 T2255 T2262 arg2Of polymorphisms,associated
R14660 T19593 T19592 arg1Of band,The
R14661 T19593 T19594 arg1Of band,that
R14662 T19593 T19595 arg1Of band,is
R14663 T19593 T19597 arg2Of band,recognized
R14664 T19593 T19608 arg1Of band,can
R14665 T19593 T19609 arg1Of band,be
R14666 T19593 T19610 arg2Of band,used
R14667 T19597 T19595 arg2Of recognized,is
R14668 T19597 T19596 arg1Of recognized,non-specifically
R14669 T19601 T19597 arg1Of antibody,recognized
R1467 T2171 T2172 arg1Of role,of
R14670 T19601 T19598 arg2Of antibody,by
R14671 T19601 T19599 arg1Of antibody,the
R14672 T19601 T19600 arg1Of antibody,anti-IκBα
R14673 T19601 T19602 arg1Of antibody,(
R14674 T19603 T19602 arg2Of indicated,(
R14675 T19606 T19603 arg1Of asterisk,indicated
R14676 T19606 T19604 arg2Of asterisk,by
R14677 T19606 T19605 arg1Of asterisk,an
R14678 T19607 T19602 arg3Of ),(
R14679 T19610 T19608 arg2Of used,can
R1468 T2171 T2174 arg1Of role,is
R14680 T19610 T19609 arg2Of used,be
R14681 T19610 T19611 arg1Of used,as
R14682 T19614 T19611 arg2Of control,as
R14683 T19614 T19612 arg1Of control,a
R14684 T19614 T19613 arg1Of control,loading
R14685 T19616 T19615 arg1Of translocation,Nuclear
R14686 T19616 T19617 arg1Of translocation,of
R14687 T19616 T19624 arg1Of translocation,was
R14688 T19616 T19625 arg2Of translocation,analyzed
R14689 T19618 T19619 arg1Of NF-κB,(
R1469 T2171 T2176 arg2Of role,demonstrated
R14690 T19618 T19622 arg1Of NF-κB,and
R14691 T19620 T19619 arg2Of p65,(
R14692 T19621 T19619 arg3Of ),(
R14693 T19622 T19617 arg2Of and,of
R14694 T19623 T19622 arg2Of IRF3,and
R14695 T19625 T19624 arg2Of analyzed,was
R14696 T19627 T19625 arg1Of immunoblotting,analyzed
R14697 T19627 T19626 arg2Of immunoblotting,by
R14698 T19627 T19628 arg1Of immunoblotting,of
R14699 T19629 T19630 arg1Of cytoplasmic,or
R147 T214 T213 arg2Of production,increased
R1470 T2259 T2256 arg2Of locus,in
R14700 T19631 T19630 arg2Of nuclear,or
R14701 T19632 T19628 arg2Of fractions,of
R14702 T19632 T19629 arg1Of fractions,cytoplasmic
R14703 T19632 T19631 arg1Of fractions,nuclear
R14704 T19632 T19633 arg1Of fractions,(
R14705 T19634 T19633 arg2Of C,(
R14706 T19635 T19633 arg3Of ),(
R14707 T19636 T19637 arg1Of Quantification,of
R14708 T19636 T19640 arg1Of Quantification,for
R14709 T19636 T19645 arg1Of Quantification,is
R1471 T2259 T2257 arg1Of locus,the
R14710 T19636 T19646 arg2Of Quantification,shown
R14711 T19639 T19637 arg2Of density,of
R14712 T19639 T19638 arg1Of density,band
R14713 T19642 T19643 arg1Of p65,and
R14714 T19643 T19640 arg2Of and,for
R14715 T19643 T19641 arg1Of and,nuclear
R14716 T19644 T19643 arg2Of IRF3,and
R14717 T19646 T19645 arg2Of shown,is
R14718 T19646 T19647 arg1Of shown,in
R14719 T19649 T19647 arg2Of graphs,in
R1472 T2259 T2258 arg1Of locus,A20
R14720 T19649 T19648 arg1Of graphs,bar
R14721 T19649 T19650 arg1Of graphs,(
R14722 T19651 T19650 arg2Of expressed,(
R14723 T19651 T19652 arg1Of expressed,as
R14724 T19651 T19660 arg1Of expressed,;
R14725 T19651 T19662 arg1Of expressed,0
R14726 T19654 T19652 arg2Of density,as
R14727 T19654 T19653 arg1Of density,relative
R14728 T19654 T19655 arg1Of density,compared
R14729 T19656 T19655 arg2Of to,compared
R1473 T2173 T2172 arg2Of A20,of
R14730 T19659 T19656 arg2Of lane,to
R14731 T19659 T19657 arg1Of lane,the
R14732 T19659 T19658 arg1Of lane,first
R14733 T19662 T19661 arg1Of 0, = time
R14734 T19663 T19650 arg3Of ),(
R14735 T19664 T19665 arg1Of IL-6,","
R14736 T19665 T19667 arg1Of ",",and
R14737 T19666 T19665 arg2Of TNF,","
R14738 T19668 T19667 arg2Of IFNβ,and
R14739 T19669 T19664 arg1Of levels,IL-6
R1474 T2262 T2261 arg2Of associated,are
R14740 T19669 T19666 arg1Of levels,TNF
R14741 T19669 T19668 arg1Of levels,IFNβ
R14742 T19669 T19670 arg1Of levels,in
R14743 T19669 T19680 arg1Of levels,were
R14744 T19669 T19681 arg2Of levels,determined
R14745 T19672 T19670 arg2Of supernatant,in
R14746 T19672 T19671 arg1Of supernatant,the
R14747 T19672 T19673 arg1Of supernatant,of
R14748 T19674 T19673 arg2Of cells,of
R14749 T19674 T19675 arg2Of cells,used
R1475 T2262 T2263 arg1Of associated,with
R14750 T19675 T19676 arg1Of used,in
R14751 T19678 T19676 arg2Of B,in
R14752 T19678 T19677 arg2Of B,(
R14753 T19679 T19677 arg3Of ),(
R14754 T19681 T19680 arg2Of determined,were
R14755 T19683 T19684 arg1Of bioassay,(
R14756 T19683 T19687 arg1Of bioassay,and
R14757 T19685 T19684 arg2Of IL-6,(
R14758 T19686 T19684 arg3Of ),(
R14759 T19687 T19694 arg1Of and,as
R1476 T2266 T2264 arg1Of diseases,several
R14760 T19687 T19699 arg1Of and,and
R14761 T19688 T19687 arg2Of ELISA,and
R14762 T19688 T19689 arg1Of ELISA,(
R14763 T19690 T19691 arg1Of TNF,and
R14764 T19691 T19689 arg2Of and,(
R14765 T19692 T19691 arg2Of IFNβ,and
R14766 T19693 T19689 arg3Of ),(
R14767 T19695 T19694 arg2Of described,as
R14768 T19695 T19696 arg1Of described,in
R14769 T19698 T19696 arg2Of ‘materials,in
R1477 T2266 T2265 arg1Of diseases,autoimmune
R14770 T19698 T19697 arg1Of ‘materials,the
R14771 T19699 T19681 arg1Of and,determined
R14772 T19699 T19682 arg2Of and,by
R14773 T19701 T19699 arg2Of section,and
R14774 T19701 T19700 arg1Of section,methods’
R14775 T19701 T19702 arg1Of section,(
R14776 T19703 T19702 arg2Of D,(
R14777 T19704 T19702 arg3Of ),(
R14778 T19705 T19706 arg1Of Data,are
R14779 T19705 T19707 arg1Of Data,representative
R1478 T2266 T2267 arg1Of diseases,and
R14780 T19707 T19706 arg2Of representative,are
R14781 T19707 T19708 arg1Of representative,of
R14782 T19711 T19708 arg2Of experiments,of
R14783 T19711 T19709 arg1Of experiments,2
R14784 T19711 T19710 arg1Of experiments,independent
R1479 T2267 T2263 arg2Of and,with
R148 T214 T215 arg1Of production,of
R1480 T2176 T2174 arg2Of demonstrated,is
R1481 T2269 T2267 arg2Of inflammation,and
R1482 T2269 T2268 arg1Of inflammation,chronic
R1483 T2269 T2270 arg1Of inflammation,[
R1484 T2271 T2270 arg2Of 45,[
R1485 T2272 T2270 arg3Of ],[
R1486 T2273 T2275 arg1Of In,to
R1487 T2176 T2175 arg1Of demonstrated,clearly
R1488 T2274 T2273 arg2Of contrast,In
R1489 T2179 T2176 arg1Of fact,demonstrated
R149 T217 T216 arg1Of cytokines,proinflammatory
R1490 T2278 T2277 arg1Of established,well
R1491 T2179 T2177 arg2Of fact,by
R1492 T2279 T2273 arg3Of function,In
R1493 T2279 T2276 arg1Of function,its
R1494 T2279 T2278 arg1Of function,established
R1495 T2279 T2280 arg1Of function,in
R1496 T2179 T2178 arg1Of fact,the
R1497 T2282 T2280 arg2Of regulation,in
R1498 T2282 T2281 arg1Of regulation,the
R1499 T2282 T2283 arg1Of regulation,of
R15 T86 T84 arg1Of response,innate
R150 T217 T218 arg1Of cytokines,","
R1500 T2183 T2181 arg1Of mice,A20
R1501 T2285 T2283 arg2Of responses,of
R1502 T2285 T2284 arg1Of responses,proinflammatory
R1503 T2288 T2287 arg1Of role,the
R1504 T2288 T2289 arg1Of role,of
R1505 T2288 T2291 arg1Of role,in
R1506 T2288 T2298 arg1Of role,is
R1507 T2288 T2301 arg2Of role,described
R1508 T2288 T2303 arg2Of role,limited
R1509 T2290 T2289 arg2Of A20,of
R151 T218 T220 arg1Of ",",and
R1510 T2183 T2182 arg1Of mice,deficient
R1511 T2183 T2184 arg1Of mice,die
R1512 T2184 T2179 arg2Of die,fact
R1513 T2293 T2291 arg2Of regulation,in
R1514 T2293 T2292 arg1Of regulation,the
R15147 T20324 T20326 arg1Of A20,regulates
R15148 T20326 T20325 arg1Of regulates,negatively
R15149 T20329 T20326 arg2Of expression,regulates
R1515 T2293 T2294 arg1Of regulation,of
R15150 T20329 T20327 arg1Of expression,IAV-induced
R15151 T20329 T20328 arg1Of expression,gene
R15152 T20329 T20330 arg1Of expression,in
R15153 T20331 T20332 arg1Of BMDM,and
R15154 T20332 T20330 arg2Of and,in
R15155 T20334 T20332 arg2Of macrophages,and
R15156 T20334 T20333 arg1Of macrophages,alveolar
R15157 T20336 T20335 arg2Of A–B,(
R15158 T20337 T20335 arg3Of ),(
R15159 T20338 T20335 arg1Of BMDM,(
R1516 T2184 T2180 arg1Of die,that
R15160 T20338 T20339 arg2Of BMDM,isolated
R15161 T20338 T20345 arg1Of BMDM,were
R15162 T20338 T20346 arg2Of BMDM,infected
R15163 T20339 T20340 arg1Of isolated,from
R15164 T20341 T20342 arg1Of A20myel-WT,and
R15165 T20343 T20342 arg2Of A20myel-KO,and
R15166 T20344 T20340 arg2Of animals,from
R15167 T20344 T20341 arg1Of animals,A20myel-WT
R15168 T20344 T20343 arg1Of animals,A20myel-KO
R15169 T20346 T20345 arg2Of infected,were
R1517 T2297 T2294 arg2Of responses,of
R15170 T20346 T20347 arg1Of infected,with
R15171 T20348 T20347 arg2Of IAV,with
R15172 T20348 T20349 arg1Of IAV,(
R15173 T20350 T20349 arg2Of moi,(
R15174 T20350 T20351 arg1Of moi,1
R15175 T20352 T20349 arg3Of ),(
R15176 T20357 T20353 arg2Of infection,At
R15177 T20357 T20354 arg1Of infection,different
R15178 T20357 T20355 arg1Of infection,hours
R15179 T20357 T20356 arg1Of infection,post
R1518 T2297 T2295 arg1Of responses,antiviral
R15180 T20360 T20358 arg2Of p.i.,(
R15181 T20360 T20359 arg1Of p.i.,hours
R15182 T20361 T20358 arg3Of ),(
R15183 T20362 T20358 arg1Of cells,(
R15184 T20362 T20363 arg1Of cells,were
R15185 T20362 T20364 arg2Of cells,lysed
R15186 T20364 T20363 arg2Of lysed,were
R15187 T20364 T20365 arg1Of lysed,and
R15188 T20365 T20353 arg1Of and,At
R15189 T20366 T20367 arg1Of IL-6,","
R1519 T2297 T2296 arg1Of responses,immune
R15190 T20367 T20369 arg1Of ",",and
R15191 T20368 T20367 arg2Of IFNβ,","
R15192 T20370 T20369 arg2Of A20,and
R15193 T20372 T20366 arg1Of expression,IL-6
R15194 T20372 T20368 arg1Of expression,IFNβ
R15195 T20372 T20370 arg1Of expression,A20
R15196 T20372 T20371 arg1Of expression,mRNA
R15197 T20372 T20373 arg1Of expression,was
R15198 T20372 T20374 arg2Of expression,analyzed
R15199 T20374 T20365 arg2Of analyzed,and
R152 T219 T218 arg2Of chemokines,","
R1520 T2184 T2185 arg1Of die,early
R15200 T20374 T20373 arg2Of analyzed,was
R15201 T20376 T20374 arg1Of qPCR,analyzed
R15202 T20376 T20375 arg2Of qPCR,by
R15203 T20376 T20377 arg1Of qPCR,(
R15204 T20378 T20377 arg2Of A,(
R15205 T20379 T20377 arg3Of ),(
R15206 T20381 T20380 arg1Of hours,18
R15207 T20381 T20382 arg2Of hours,post
R15208 T20381 T20387 arg1Of hours,was
R15209 T20381 T20388 arg2Of hours,analyzed
R1521 T2184 T2186 arg1Of die,after
R15210 T20386 T20382 arg1Of supernatant,post
R15211 T20386 T20383 arg1Of supernatant,infection
R15212 T20386 T20384 arg1Of supernatant,cell
R15213 T20386 T20385 arg1Of supernatant,culture
R15214 T20388 T20387 arg2Of analyzed,was
R15215 T20388 T20389 arg1Of analyzed,for
R15216 T20390 T20391 arg1Of TNF,and
R15217 T20392 T20391 arg2Of IFNβ,and
R15218 T20394 T20389 arg2Of levels,for
R15219 T20394 T20390 arg1Of levels,TNF
R1522 T2300 T2299 arg1Of well,less
R15220 T20394 T20392 arg1Of levels,IFNβ
R15221 T20394 T20393 arg1Of levels,protein
R15222 T20396 T20397 arg1Of ELISA,and
R15223 T20398 T20397 arg2Of multiplexing,and
R15224 T20399 T20388 arg1Of technologies,analyzed
R15225 T20399 T20395 arg2Of technologies,by
R15226 T20399 T20396 arg1Of technologies,ELISA
R15227 T20399 T20398 arg1Of technologies,multiplexing
R15228 T20399 T20400 arg1Of technologies,(
R15229 T20399 T20408 modOf technologies,ges
R1523 T2187 T2186 arg2Of birth,after
R15230 T20401 T20400 arg2Of B,(
R15231 T20402 T20400 arg3Of ),(
R15232 T20404 T20403 arg2Of (C–,.
R15233 T20405 T20403 arg3Of D,.
R15234 T20407 T20403 arg1Of ar macropha,.
R15235 T20407 T20406 arg1Of ar macropha,) Alveol
R15236 T20407 T20408 arg1Of ar macropha,ges
R15237 T20407 T20410 arg2Of ar macropha,mock tr
R15238 T20407 T20412 arg2Of ar macropha,ted or i
R15239 T20410 T20411 arg1Of mock tr,ea
R1524 T2301 T2302 arg1Of described,and
R15240 T20411 T20408 arg2Of ea,ges
R15241 T20411 T20409 arg1Of ea,were
R15242 T20412 T20411 arg2Of ted or i,ea
R15243 T20412 T20413 arg1Of ted or i,nfec
R15244 T20412 T20419 arg1Of ted or i,V (
R15245 T20414 T20413 arg2Of ted,nfec
R15246 T20414 T20415 arg1Of ted,w
R15247 T20416 T20415 arg2Of ith,w
R15248 T20416 T20417 arg1Of ith,I
R15249 T20418 T20415 arg3Of A,w
R1525 T2302 T2273 arg1Of and,In
R15250 T20421 T20419 arg2Of i 1) ,V (
R15251 T20421 T20420 arg1Of i 1) ,mo
R15252 T20422 T20423 arg1Of IL-6,and
R15253 T20423 T20427 arg1Of and,was
R15254 T20423 T20428 arg2Of and,determined
R15255 T20426 T20423 arg2Of expression,and
R15256 T20426 T20424 arg1Of expression,IFNβ
R15257 T20426 T20425 arg1Of expression,mRNA
R15258 T20428 T20427 arg2Of determined,was
R15259 T20430 T20428 arg1Of qPCR,determined
R1526 T2302 T2286 arg1Of and,","
R15260 T20430 T20429 arg2Of qPCR,by
R15261 T20430 T20431 arg1Of qPCR,(
R15262 T20432 T20431 arg2Of C,(
R15263 T20433 T20431 arg3Of ),(
R15264 T20436 T20434 arg1Of supernatant,Cell
R15265 T20436 T20435 arg1Of supernatant,culture
R15266 T20436 T20437 arg1Of supernatant,was
R15267 T20436 T20438 arg2Of supernatant,analyzed
R15268 T20438 T20437 arg2Of analyzed,was
R15269 T20438 T20439 arg1Of analyzed,for
R1527 T2302 T2298 arg2Of and,is
R15270 T20440 T20441 arg1Of IL-6,and
R15271 T20441 T20439 arg2Of and,for
R15272 T20444 T20441 arg2Of levels,and
R15273 T20444 T20442 arg1Of levels,IFNβ
R15274 T20444 T20443 arg1Of levels,protein
R15275 T20446 T20447 arg1Of ELISA,and
R15276 T20447 T20438 arg1Of and,analyzed
R15277 T20447 T20445 arg2Of and,by
R15278 T20449 T20447 arg2Of technologies,and
R15279 T20449 T20448 arg1Of technologies,multiplexing
R1528 T2302 T2300 arg1Of and,well
R15280 T20449 T20450 arg1Of technologies,(
R15281 T20451 T20450 arg2Of D,(
R15282 T20452 T20450 arg3Of ),(
R15283 T20454 T20453 arg1Of bars,Error
R15284 T20454 T20455 arg1Of bars,represent
R15285 T20457 T20455 arg2Of values,represent
R15286 T20457 T20456 arg1Of values,mean
R15287 T20457 T20458 arg1Of values,(
R15288 T20457 T20462 arg1Of values,of
R15289 T20459 T20458 arg2Of +/−,(
R1529 T2303 T2302 arg2Of limited,and
R15290 T20460 T20459 arg2Of SEM,+/−
R15291 T20461 T20458 arg3Of ),(
R15292 T20464 T20462 arg2Of samples,of
R15293 T20464 T20463 arg1Of samples,2–3
R15294 T20465 T20466 arg1Of Results,are
R15295 T20465 T20467 arg1Of Results,representative
R15296 T20467 T20466 arg2Of representative,are
R15297 T20467 T20468 arg1Of representative,for
R15298 T20472 T20468 arg2Of ***p,for
R15299 T20472 T20469 arg1Of ***p,2
R153 T220 T215 arg2Of and,of
R1530 T2303 T2304 arg1Of limited,to
R15300 T20472 T20470 arg1Of ***p,independent
R15301 T20472 T20471 arg1Of ***p,experiments.
R15302 T20472 T20473 arg1Of ***p,<
R15303 T20473 T20474 arg1Of <,"0,001"
R1531 T2306 T2304 arg2Of number,to
R1532 T2306 T2305 arg1Of number,a
R1533 T2306 T2307 arg1Of number,of
R1534 T2309 T2308 arg1Of vitro,in
R1535 T2310 T2307 arg2Of studies,of
R1536 T2310 T2309 arg1Of studies,vitro
R1537 T2310 T2311 arg1Of studies,using
R1538 T2311 T2319 arg1Of using,","
R1539 T2311 T2320 modOf using,indicating
R154 T223 T220 arg2Of interferon,and
R1540 T2187 T2188 arg1Of birth,due
R1541 T2312 T2313 arg1Of overexpression,or
R1542 T2313 T2311 arg2Of or,using
R1543 T2313 T2315 arg1Of or,in
R1544 T2188 T2189 arg1Of due,to
R1545 T2314 T2313 arg2Of silencing,or
R1546 T2192 T2190 arg1Of inflammation,severe
R1547 T2318 T2315 arg2Of lines,in
R1548 T2318 T2316 arg1Of lines,specific
R1549 T2318 T2317 arg1Of lines,cell
R15498 T20806 T20805 arg1Of deficiency,A20
R15499 T20806 T20807 arg1Of deficiency,in
R155 T223 T221 arg1Of interferon,type
R1550 T2192 T2191 arg1Of inflammation,multi-organ
R15500 T20806 T20810 arg1Of deficiency,protects
R15501 T20809 T20807 arg2Of cells,in
R15502 T20809 T20808 arg1Of cells,myeloid
R15503 T20810 T20811 arg1Of protects,against
R15504 T20814 T20811 arg2Of infection,against
R15505 T20814 T20812 arg1Of infection,IAV
R15506 T20814 T20813 arg1Of infection,lung
R15507 T20815 T20816 arg1Of A20myel-WT,and
R15508 T20817 T20816 arg2Of A20myel-KO,and
R15509 T20818 T20815 arg1Of mice,A20myel-WT
R1551 T2322 T2323 arg1Of A20,may
R15510 T20818 T20817 arg1Of mice,A20myel-KO
R15511 T20818 T20819 arg1Of mice,were
R15512 T20818 T20820 arg2Of mice,infected
R15513 T20820 T20819 arg2Of infected,were
R15514 T20820 T20821 arg1Of infected,intranasally
R15515 T20820 T20822 arg1Of infected,with
R15516 T20820 T20828 arg1Of infected,and
R15517 T20825 T20822 arg2Of dose,with
R15518 T20825 T20823 arg1Of dose,a
R15519 T20825 T20824 arg1Of dose,sublethal
R1552 T2192 T2193 arg1Of inflammation,and
R15520 T20825 T20826 arg1Of dose,of
R15521 T20827 T20826 arg2Of IAV,of
R15522 T20830 T20829 arg1Of loss,weight
R15523 T20830 T20831 arg1Of loss,was
R15524 T20830 T20832 arg2Of loss,monitored
R15525 T20832 T20828 arg2Of monitored,and
R15526 T20832 T20831 arg2Of monitored,was
R15527 T20832 T20833 arg1Of monitored,(
R15528 T20834 T20833 arg2Of A,(
R15529 T20835 T20833 arg3Of ),(
R1553 T2193 T2189 arg2Of and,to
R15530 T20838 T20839 arg1Of 4,","
R15531 T20839 T20841 arg1Of ",",and
R15532 T20840 T20839 arg2Of 7,","
R15533 T20842 T20841 arg2Of 10,and
R15534 T20844 T20836 arg2Of infection,At
R15535 T20844 T20837 arg1Of infection,day
R15536 T20844 T20838 arg1Of infection,4
R15537 T20844 T20840 arg1Of infection,7
R15538 T20844 T20842 arg1Of infection,10
R15539 T20844 T20843 arg1Of infection,post
R1554 T2322 T2324 arg1Of A20,regulate
R15540 T20846 T20845 arg2Of p.i.,(
R15541 T20847 T20845 arg3Of ),(
R15542 T20849 T20845 arg1Of titers,(
R15543 T20849 T20848 arg1Of titers,viral
R15544 T20849 T20850 arg1Of titers,in
R15545 T20849 T20853 arg1Of titers,were
R15546 T20849 T20854 arg2Of titers,measured
R15547 T20849 T20856 arg2Of titers,expressed
R15548 T20852 T20850 arg2Of lung,in
R15549 T20852 T20851 arg1Of lung,the
R1555 T2194 T2193 arg2Of cachexia,and
R15550 T20854 T20855 arg1Of measured,and
R15551 T20855 T20836 arg1Of and,At
R15552 T20855 T20853 arg2Of and,were
R15553 T20856 T20855 arg2Of expressed,and
R15554 T20856 T20857 arg1Of expressed,as
R15555 T20859 T20857 arg2Of TCID50,as
R15556 T20859 T20858 arg1Of TCID50,mean
R15557 T20859 T20860 arg1Of TCID50,(
R15558 T20861 T20860 arg2Of B,(
R15559 T20862 T20860 arg3Of ),(
R1556 T2324 T2320 arg2Of regulate,indicating
R15560 T20865 T20863 arg1Of line,The
R15561 T20865 T20864 arg1Of line,dashed
R15562 T20865 T20866 arg1Of line,represents
R15563 T20869 T20866 arg2Of limit,represents
R15564 T20869 T20867 arg1Of limit,the
R15565 T20869 T20868 arg1Of limit,detection
R15566 T20870 T20871 arg1Of ND,","
R15567 T20870 T20873 arg1Of ND,detectable
R15568 T20873 T20872 arg1Of detectable,not
R15569 T20874 T20875 arg1Of BAL,was
R1557 T2324 T2321 arg1Of regulate,that
R15570 T20874 T20876 arg2Of BAL,isolated
R15571 T20876 T20875 arg2Of isolated,was
R15572 T20876 T20877 arg1Of isolated,from
R15573 T20876 T20881 arg1Of isolated,at
R15574 T20876 T20883 arg1Of isolated,","
R15575 T20880 T20877 arg2Of mice,from
R15576 T20880 T20878 arg1Of mice,IAV
R15577 T20880 T20879 arg1Of mice,infected
R15578 T20882 T20881 arg2Of 4,at
R15579 T20884 T20885 arg1Of 7,and
R1558 T2324 T2323 arg2Of regulate,may
R15580 T20886 T20885 arg2Of 10,and
R15581 T20888 T20884 arg1Of p.i.,7
R15582 T20888 T20886 arg1Of p.i.,10
R15583 T20888 T20887 arg1Of p.i.,days
R15584 T20888 T20889 arg1Of p.i.,and
R15585 T20889 T20901 arg1Of and,were
R15586 T20889 T20902 arg2Of and,analyzed
R15587 T20890 T20891 arg1Of KC,","
R15588 T20891 T20893 arg1Of ",",","
R15589 T20892 T20891 arg2Of MIP-2,","
R1559 T2325 T2326 arg1Of RIG-I-,and
R15590 T20893 T20895 arg1Of ",",","
R15591 T20894 T20893 arg2Of MCP-1,","
R15592 T20895 T20897 arg1Of ",",and
R15593 T20896 T20895 arg2Of IL-6,","
R15594 T20897 T20889 arg2Of and,and
R15595 T20900 T20897 arg2Of levels,and
R15596 T20900 T20898 arg1Of levels,IFNα
R15597 T20900 T20899 arg1Of levels,protein
R15598 T20902 T20883 arg2Of analyzed,","
R15599 T20902 T20901 arg2Of analyzed,were
R156 T223 T222 arg1Of interferon,I
R1560 T2194 T2195 arg1Of cachexia,[
R15600 T20904 T20905 arg1Of ELISA,and
R15601 T20906 T20905 arg2Of multiplexing,and
R15602 T20907 T20902 arg1Of technologies,analyzed
R15603 T20907 T20903 arg2Of technologies,by
R15604 T20907 T20904 arg1Of technologies,ELISA
R15605 T20907 T20906 arg1Of technologies,multiplexing
R15606 T20907 T20908 arg1Of technologies,(
R15607 T20909 T20908 arg2Of C,(
R15608 T20910 T20908 arg3Of ),(
R15609 T20912 T20911 arg1Of numbers,Absolute
R1561 T2326 T2329 arg1Of and,to
R15610 T20912 T20913 arg1Of numbers,of
R15611 T20912 T20923 arg1Of numbers,were
R15612 T20912 T20924 arg2Of numbers,analyzed
R15613 T20916 T20917 arg1Of macrophages,","
R15614 T20917 T20919 arg1Of ",",and
R15615 T20918 T20917 arg2Of neutrophils,","
R15616 T20919 T20913 arg2Of and,of
R15617 T20919 T20914 arg1Of and,resident
R15618 T20919 T20915 arg1Of and,alveolar
R15619 T20919 T20921 arg1Of and,in
R1562 T2326 T2331 arg1Of and,and
R15620 T20920 T20919 arg2Of monocytes,and
R15621 T20922 T20921 arg2Of BAL,in
R15622 T20924 T20923 arg2Of analyzed,were
R15623 T20924 T20928 arg1Of analyzed,at
R15624 T20927 T20924 arg1Of cytometry,analyzed
R15625 T20927 T20925 arg2Of cytometry,by
R15626 T20927 T20926 arg1Of cytometry,flow
R15627 T20929 T20930 arg1Of 4,","
R15628 T20930 T20932 arg1Of ",",and
R15629 T20931 T20930 arg2Of 7,","
R1563 T2196 T2195 arg2Of 37,[
R15630 T20933 T20932 arg2Of 10,and
R15631 T20935 T20928 arg2Of p.i.,at
R15632 T20935 T20929 arg1Of p.i.,4
R15633 T20935 T20931 arg1Of p.i.,7
R15634 T20935 T20933 arg1Of p.i.,10
R15635 T20935 T20934 arg1Of p.i.,days
R15636 T20935 T20936 arg1Of p.i.,(
R15637 T20937 T20936 arg2Of D,(
R15638 T20938 T20936 arg3Of ),(
R15639 T20939 T20940 arg1Of Numbers,are
R1564 T2328 T2326 arg2Of signaling,and
R15640 T20939 T20952 arg1Of Numbers,are
R15641 T20939 T20953 arg1Of Numbers,representative
R15642 T20940 T20951 arg1Of are,and
R15643 T20941 T20942 arg1Of averages,+/−
R15644 T20942 T20940 arg2Of +/−,are
R15645 T20942 T20944 arg1Of +/−,of
R15646 T20943 T20942 arg2Of SEM,+/−
R15647 T20947 T20945 arg1Of 5,at
R15648 T20947 T20946 arg1Of 5,least
R15649 T20948 T20944 arg2Of mice,of
R1565 T2328 T2327 arg1Of signaling,TLR3-induced
R15650 T20948 T20947 arg1Of mice,5
R15651 T20948 T20949 arg1Of mice,per
R15652 T20950 T20949 arg2Of group,per
R15653 T20952 T20951 arg2Of are,and
R15654 T20953 T20952 arg2Of representative,are
R15655 T20953 T20954 arg1Of representative,of
R15656 T20960 T20954 arg2Of 0.05,of
R15657 T20960 T20955 arg1Of 0.05,2
R15658 T20960 T20956 arg1Of 0.05,independent
R15659 T20960 T20957 arg1Of 0.05,experiments.
R1566 T2330 T2329 arg2Of NF-κB,to
R15660 T20960 T20958 arg1Of 0.05,*p
R15661 T20960 T20959 arg1Of 0.05,<
R15662 T20960 T20961 arg1Of 0.05,;
R15663 T20964 T20961 arg2Of 0.01,;
R15664 T20964 T20962 arg1Of 0.01,**p
R15665 T20964 T20963 arg1Of 0.01,<
R1567 T2331 T2324 arg2Of and,regulate
R1568 T2197 T2195 arg3Of ],[
R1569 T2199 T2198 arg1Of recently,More
R157 T225 T224 arg1Of vivo,In
R1570 T2334 T2333 arg2Of 49,[
R1571 T2202 T2201 arg1Of targeting,gene
R1572 T2335 T2333 arg3Of ],[
R1573 T2336 T2331 arg2Of –,and
R1574 T2336 T2332 arg1Of –,IRF-3
R1575 T2336 T2333 arg1Of –,[
R1576 T2336 T2337 arg1Of –,[
R1577 T2338 T2337 arg2Of 52,[
R1578 T2339 T2337 arg3Of ],[
R1579 T2202 T2203 arg1Of targeting,of
R158 T226 T227 arg1Of this,was
R1580 T2202 T2205 arg1Of targeting,in
R1581 T2202 T2209 arg1Of targeting,was
R1582 T2202 T2210 arg2Of targeting,shown
R1583 T2345 T2344 arg1Of vivo,in
R1584 T2202 T2212 arg1Of targeting,be
R15845 T21247 T21246 arg1Of deficiency,A20
R15846 T21247 T21248 arg1Of deficiency,in
R15847 T21247 T21251 arg1Of deficiency,protects
R15848 T21250 T21248 arg2Of cells,in
R15849 T21250 T21249 arg1Of cells,myeloid
R1585 T2346 T2342 arg1Of role,the
R15850 T21251 T21252 arg1Of protects,against
R15851 T21255 T21252 arg2Of infection,against
R15852 T21255 T21253 arg1Of infection,lethal
R15853 T21255 T21254 arg1Of infection,IAV
R15854 T21256 T21257 arg1Of A20myel-WT,(
R15855 T21256 T21260 arg1Of A20myel-WT,and
R15856 T21258 T21257 arg2Of n = 11,(
R15857 T21259 T21257 arg3Of ),(
R15858 T21260 T21266 modOf and,were
R15859 T21260 T21285 arg1Of and,and
R1586 T2346 T2343 arg1Of role,precise
R15860 T21261 T21260 arg2Of A20myel-KO,and
R15861 T21261 T21262 arg1Of A20myel-KO,(
R15862 T21263 T21262 arg2Of n = 11,(
R15863 T21264 T21262 arg3Of ),(
R15864 T21265 T21266 arg1Of mice,were
R15865 T21265 T21268 arg2Of mice,infected
R15866 T21268 T21266 arg2Of infected,were
R15867 T21268 T21267 arg1Of infected,intranasally
R15868 T21268 T21269 arg1Of infected,with
R15869 T21272 T21269 arg2Of dose,with
R1587 T2346 T2345 arg1Of role,vivo
R15870 T21272 T21270 arg1Of dose,a
R15871 T21272 T21271 arg1Of dose,lethal
R15872 T21272 T21273 arg1Of dose,of
R15873 T21272 T21277 arg1Of dose,(
R15874 T21272 T21282 arg1Of dose,(
R15875 T21274 T21275 arg1Of IAV,and
R15876 T21275 T21273 arg2Of and,of
R15877 T21276 T21275 arg2Of survival,and
R15878 T21278 T21277 arg2Of p,(
R15879 T21278 T21279 arg1Of p,<
R1588 T2346 T2347 arg1Of role,of
R15880 T21278 T21280 arg1Of p,0.001
R15881 T21281 T21277 arg3Of ),(
R15882 T21283 T21282 arg2Of A,(
R15883 T21284 T21282 arg3Of ),(
R15884 T21285 T21293 arg1Of and,was
R15885 T21285 T21294 arg2Of and,monitored
R15886 T21287 T21286 arg1Of loss,weight
R15887 T21287 T21288 arg1Of loss,+/−
R15888 T21288 T21285 arg2Of +/−,and
R15889 T21289 T21288 arg2Of SEM,+/−
R1589 T2346 T2349 arg1Of role,in
R15890 T21289 T21290 arg1Of SEM,(
R15891 T21291 T21290 arg2Of B,(
R15892 T21292 T21290 arg3Of ),(
R15893 T21294 T21293 arg2Of monitored,was
R15894 T21294 T21295 arg1Of monitored,for
R15895 T21297 T21298 arg1Of 21,and
R15896 T21299 T21298 arg2Of 15,and
R15897 T21301 T21295 arg2Of p.i,for
R15898 T21301 T21296 arg1Of p.i,respectively
R15899 T21301 T21297 arg1Of p.i,21
R159 T226 T228 arg2Of this,associated
R1590 T2346 T2355 arg1Of role,remains
R15900 T21301 T21299 arg1Of p.i,15
R15901 T21301 T21300 arg1Of p.i,days
R15902 T21303 T21302 arg1Of fluid,BAL
R15903 T21303 T21304 arg1Of fluid,was
R15904 T21303 T21305 arg2Of fluid,collected
R15905 T21305 T21304 arg2Of collected,was
R15906 T21305 T21306 arg1Of collected,from
R15907 T21308 T21309 arg1Of type,(
R15908 T21308 T21312 arg1Of type,and
R15909 T21310 T21309 arg2Of A20myel-WT,(
R1591 T2346 T2357 arg1Of role,be
R15910 T21311 T21309 arg3Of ),(
R15911 T21313 T21312 arg2Of A20myel-KO,and
R15912 T21314 T21306 arg2Of mice,from
R15913 T21314 T21307 arg1Of mice,wild
R15914 T21314 T21308 arg1Of mice,type
R15915 T21314 T21313 arg1Of mice,A20myel-KO
R15916 T21316 T21315 arg1Of days,6
R15917 T21316 T21317 arg1Of days,following
R15918 T21316 T21336 arg1Of days,were
R15919 T21316 T21337 arg2Of days,determined
R1592 T2346 T2358 arg2Of role,clarified
R15920 T21318 T21319 arg1Of infection,with
R15921 T21318 T21324 arg1Of infection,and
R15922 T21323 T21319 arg2Of IAV,with
R15923 T21323 T21320 arg1Of IAV,a
R15924 T21323 T21321 arg1Of IAV,lethal
R15925 T21323 T21322 arg1Of IAV,dose
R15926 T21324 T21317 arg2Of and,following
R15927 T21325 T21326 arg1Of KC,","
R15928 T21326 T21328 arg1Of ",",","
R15929 T21327 T21326 arg2Of MIP-2,","
R1593 T2348 T2347 arg2Of A20,of
R15930 T21328 T21330 arg1Of ",",","
R15931 T21329 T21328 arg2Of MCP-1,","
R15932 T21330 T21332 arg1Of ",",and
R15933 T21331 T21330 arg2Of IL-6,","
R15934 T21332 T21324 arg2Of and,and
R15935 T21335 T21332 arg2Of levels,and
R15936 T21335 T21333 arg1Of levels,IFNα
R15937 T21335 T21334 arg1Of levels,protein
R15938 T21337 T21304 modOf determined,was
R15939 T21337 T21336 arg2Of determined,were
R1594 T2202 T2213 arg2Of targeting,associated
R15940 T21337 T21338 arg1Of determined,(
R15941 T21339 T21338 arg2Of C,(
R15942 T21340 T21338 arg3Of ),(
R15943 T21342 T21341 arg1Of numbers,Absolute
R15944 T21342 T21343 arg1Of numbers,of
R15945 T21342 T21352 arg1Of numbers,were
R15946 T21342 T21353 arg2Of numbers,analyzed
R15947 T21345 T21346 arg1Of macrophages,","
R15948 T21346 T21348 arg1Of ",",and
R15949 T21347 T21346 arg2Of neutrophils,","
R1595 T2202 T2228 arg1Of targeting,illustrating
R15950 T21348 T21343 arg2Of and,of
R15951 T21348 T21344 arg1Of and,alveolar
R15952 T21348 T21350 arg1Of and,in
R15953 T21349 T21348 arg2Of monocytes,and
R15954 T21351 T21350 arg2Of BAL,in
R15955 T21353 T21352 arg2Of analyzed,were
R15956 T21356 T21353 arg1Of cytometry,analyzed
R15957 T21356 T21354 arg2Of cytometry,by
R15958 T21356 T21355 arg1Of cytometry,flow
R15959 T21356 T21357 arg1Of cytometry,at
R1596 T2351 T2349 arg2Of response,in
R15960 T21360 T21357 arg2Of p.i.,at
R15961 T21360 T21358 arg1Of p.i.,6
R15962 T21360 T21359 arg1Of p.i.,days
R15963 T21360 T21361 arg1Of p.i.,(
R15964 T21362 T21361 arg2Of D,(
R15965 T21363 T21361 arg3Of ),(
R15966 T21364 T21365 arg1Of Numbers,are
R15967 T21366 T21367 arg1Of averages,+/−
R15968 T21367 T21365 arg2Of +/−,are
R15969 T21367 T21369 arg1Of +/−,of
R1597 T2351 T2350 arg1Of response,the
R15970 T21368 T21367 arg2Of SEM,+/−
R15971 T21372 T21370 arg1Of 5,at
R15972 T21372 T21371 arg1Of 5,least
R15973 T21373 T21369 arg2Of mice,of
R15974 T21373 T21372 arg1Of mice,5
R15975 T21373 T21374 arg1Of mice,per
R15976 T21375 T21374 arg2Of group,per
R15977 T21376 T21377 arg1Of Data,are
R15978 T21376 T21378 arg1Of Data,representative
R15979 T21378 T21377 arg2Of representative,are
R1598 T2351 T2352 arg1Of response,to
R15980 T21378 T21379 arg1Of representative,of
R15981 T21382 T21380 arg1Of experiments.,2
R15982 T21382 T21381 arg1Of experiments.,independent
R15983 T21382 T21383 arg1Of experiments.,*p
R15984 T21382 T21386 arg1Of experiments.,;
R15985 T21385 T21383 arg2Of 0.05,*p
R15986 T21385 T21384 arg1Of 0.05,<
R15987 T21389 T21386 arg2Of 0.01,;
R15988 T21389 T21387 arg1Of 0.01,**p
R15989 T21389 T21388 arg1Of 0.01,<
R1599 T2204 T2203 arg2Of A20,of
R15990 T21389 T21390 arg1Of 0.01,","
R15991 T21391 T21390 arg2Of ***p,","
R15992 T21391 T21392 arg1Of ***p,<
R15993 T21393 T21379 arg2Of 0.001,of
R15994 T21393 T21382 arg1Of 0.001,experiments.
R16 T86 T85 arg1Of response,immune
R160 T228 T225 arg1Of associated,vivo
R1600 T2354 T2352 arg2Of infection,to
R1601 T2354 T2353 arg1Of infection,viral
R1602 T2355 T2340 arg1Of remains,However
R1603 T2355 T2341 arg1Of remains,","
R1604 T2208 T2205 arg2Of types,in
R1605 T2358 T2355 arg2Of clarified,remains
R1606 T2358 T2356 arg1Of clarified,to
R1607 T2358 T2357 arg2Of clarified,be
R1608 T2208 T2206 arg1Of types,specific
R1609 T2208 T2207 arg1Of types,cell
R161 T228 T227 arg2Of associated,was
R1610 T2210 T2199 arg1Of shown,recently
R1611 T2365 T2359 arg2Of mice,Using
R1612 T2365 T2360 arg1Of mice,myeloid
R1613 T2365 T2361 arg1Of mice,cell
R1614 T2365 T2362 arg1Of mice,specific
R1615 T2365 T2363 arg1Of mice,A20
R1616 T2365 T2364 arg1Of mice,knockout
R1617 T2365 T2366 arg1Of mice,(
R1618 T2365 T2369 arg1Of mice,that
R1619 T2365 T2370 arg1Of mice,were
R162 T228 T229 arg1Of associated,with
R1620 T2365 T2372 arg2Of mice,generated
R1621 T2367 T2366 arg2Of A20myel-KO,(
R1622 T2368 T2366 arg3Of ),(
R1623 T2210 T2200 arg1Of shown,","
R1624 T2372 T2370 arg2Of generated,were
R1625 T2372 T2371 arg1Of generated,recently
R1626 T2372 T2373 arg1Of generated,in
R1627 T2375 T2376 arg1Of lab,and
R1628 T2210 T2209 arg2Of shown,was
R1629 T2210 T2226 arg1Of shown,","
R163 T232 T229 arg2Of number,with
R1630 T2377 T2376 arg2Of primary,and
R1631 T2210 T2228 modOf shown,illustrating
R1632 T2378 T2373 arg2Of cells,in
R1633 T2378 T2374 arg1Of cells,our
R1634 T2378 T2375 arg1Of cells,lab
R1635 T2378 T2377 arg1Of cells,primary
R1636 T2378 T2379 arg2Of cells,derived
R1637 T2379 T2380 arg1Of derived,of
R1638 T2213 T2210 arg3Of associated,shown
R1639 T2382 T2380 arg2Of mice,of
R164 T232 T230 arg1Of number,an
R1640 T2382 T2381 arg1Of mice,these
R1641 T2384 T2359 arg1Of we,Using
R1642 T2384 T2386 arg1Of we,provide
R1643 T2386 T2359 modOf provide,Using
R1644 T2386 T2383 arg1Of provide,","
R1645 T2386 T2385 arg1Of provide,here
R1646 T2387 T2386 arg2Of evidence,provide
R1647 T2213 T2211 arg1Of associated,to
R1648 T2213 T2212 arg2Of associated,be
R1649 T2213 T2214 arg1Of associated,with
R165 T232 T231 arg2Of number,increased
R1650 T2389 T2390 arg1Of A20,is
R1651 T2390 T2387 arg2Of is,evidence
R1652 T2390 T2388 arg1Of is,that
R1653 T2215 T2216 arg1Of autoimmunity,and
R1654 T2394 T2390 arg2Of regulator,is
R1655 T2394 T2391 arg1Of regulator,a
R1656 T2394 T2392 arg1Of regulator,crucial
R1657 T2394 T2393 arg1Of regulator,negative
R1658 T2394 T2395 arg1Of regulator,of
R1659 T2216 T2214 arg2Of and,with
R166 T232 T233 arg1Of number,of
R1660 T2220 T2219 arg2Of 42,[
R1661 T2397 T2398 arg1Of proinflammatory,and
R1662 T2399 T2398 arg2Of antiviral,and
R1663 T2400 T2395 arg2Of signaling,of
R1664 T2400 T2396 arg1Of signaling,IAV-induced
R1665 T2400 T2397 arg1Of signaling,proinflammatory
R1666 T2400 T2399 arg1Of signaling,antiviral
R1667 T2400 T2401 arg1Of signaling,in
R1668 T2402 T2401 arg2Of macrophages,in
R1669 T2221 T2219 arg3Of ],[
R167 T232 T238 arg1Of number,in
R1670 T2222 T2216 arg2Of –,and
R1671 T2406 T2405 arg1Of mice,A20myel-KO
R1672 T2406 T2407 arg1Of mice,show
R1673 T2407 T2403 arg1Of show,Interestingly
R1674 T2407 T2404 arg1Of show,","
R1675 T2407 T2413 arg1Of show,in
R1676 T2407 T2419 arg1Of show,compared
R1677 T2409 T2408 arg2Of survival,enhanced
R1678 T2409 T2410 arg1Of survival,and
R1679 T2410 T2407 arg2Of and,show
R168 T235 T234 arg1Of macrophages,alveolar
R1680 T2222 T2217 arg1Of –,chronic
R1681 T2412 T2410 arg2Of morbidity,and
R1682 T2412 T2411 arg2Of morbidity,reduced
R1683 T2222 T2218 arg1Of –,inflammation
R1684 T2414 T2413 arg2Of response,in
R1685 T2414 T2415 arg1Of response,to
R1686 T2222 T2219 arg1Of –,[
R1687 T2222 T2223 arg1Of –,[
R1688 T2224 T2223 arg2Of 48,[
R1689 T2418 T2415 arg2Of infection,to
R169 T235 T236 arg1Of macrophages,and
R1690 T2418 T2416 arg1Of infection,IAV
R1691 T2418 T2417 arg1Of infection,lung
R1692 T2420 T2419 arg2Of to,compared
R1693 T2225 T2223 arg3Of ],[
R1694 T2423 T2420 arg2Of mice,to
R1695 T2423 T2421 arg1Of mice,wild
R1696 T2423 T2422 arg1Of mice,type
R1697 T2424 T2425 arg1Of Protection,against
R1698 T2424 T2427 arg1Of Protection,in
R1699 T2424 T2430 arg1Of Protection,is
R17 T86 T87 arg1Of response,provides
R170 T236 T233 arg2Of and,of
R1700 T2424 T2431 arg2Of Protection,associated
R1701 T2424 T2439 arg1Of Protection,augmented
R1702 T2424 T2453 arg1Of Protection,enhanced
R1703 T2426 T2425 arg2Of IAV,against
R1704 T2228 T2227 arg1Of illustrating,further
R1705 T2429 T2427 arg2Of mice,in
R1706 T2429 T2428 arg1Of mice,A20myel-KO
R1707 T2431 T2430 arg2Of associated,is
R1708 T2431 T2432 arg1Of associated,with
R1709 T2431 T2438 arg1Of associated,","
R171 T237 T236 arg2Of neutrophils,and
R1710 T2230 T2231 arg1Of A20,is
R1711 T2231 T2228 arg2Of is,illustrating
R1712 T2231 T2229 arg1Of is,that
R1713 T2234 T2231 arg2Of brake,is
R1714 T2434 T2433 arg2Of cytokine,increased
R1715 T2434 T2435 arg1Of cytokine,and
R1716 T2435 T2432 arg2Of and,with
R1717 T2234 T2232 arg1Of brake,an
R1718 T2437 T2435 arg2Of production,and
R1719 T2437 T2436 arg1Of production,chemokine
R172 T240 T238 arg2Of lungs,in
R1720 T2234 T2233 arg1Of brake,important
R1721 T2438 T2452 arg1Of ",",and
R1722 T2234 T2235 arg1Of brake,on
R1723 T2439 T2438 arg2Of augmented,","
R1725 T2440 T2439 arg2Of recruitment,augmented
R1726 T2440 T2441 arg1Of recruitment,of
R1727 T2444 T2441 arg2Of cells,of
R1728 T2444 T2442 arg1Of cells,innate
R1729 T2444 T2443 arg1Of cells,immune
R173 T240 T239 arg1Of lungs,the
R1730 T2444 T2446 arg1Of cells,as
R1731 T2446 T2445 arg1Of as,such
R1732 T2447 T2448 arg1Of neutophils,and
R1733 T2448 T2446 arg2Of and,as
R1734 T2450 T2448 arg2Of macrophages,and
R1735 T2450 T2449 arg1Of macrophages,alveolar
R1737 T2452 T2451 arg1Of and,","
R1738 T2453 T2452 arg2Of enhanced,and
R174 T240 T241 arg1Of lungs,of
R1740 T2455 T2453 arg2Of clearance,enhanced
R1742 T2455 T2454 arg1Of clearance,viral
R1745 T2457 T2456 arg1Of results,These
R1746 T2457 T2458 arg1Of results,suggest
R1748 T2460 T2467 arg1Of boosting,by
R175 T244 T241 arg2Of mice,of
R1751 T2460 T2474 arg1Of boosting,might
R1752 T2460 T2475 arg1Of boosting,have
R1754 T2464 T2460 arg2Of response,boosting
R1755 T2464 T2461 arg1Of response,the
R1756 T2464 T2462 arg1Of response,innate
R1757 T2464 T2463 arg1Of response,immune
R1758 T2464 T2465 arg1Of response,to
R1759 T2466 T2465 arg2Of IAV,to
R176 T244 T242 arg1Of mice,IAV
R1761 T2468 T2467 arg2Of targeting,by
R1763 T2470 T2468 arg2Of activity,targeting
R1764 T2470 T2469 arg1Of activity,A20
R1765 T2470 T2471 arg1Of activity,in
R1767 T2473 T2471 arg2Of cells,in
R1768 T2473 T2472 arg1Of cells,myeloid
R1769 T2475 T2458 arg2Of have,suggest
R177 T244 T243 arg1Of mice,infected
R1770 T2475 T2459 arg1Of have,that
R1771 T2475 T2474 arg2Of have,might
R1773 T2477 T2475 arg2Of potential,have
R1774 T2477 T2476 arg1Of potential,therapeutic
R178 T252 T247 arg1Of mice,myeloid
R179 T252 T248 arg1Of mice,cell
R18 T86 T99 arg1Of response,responding
R180 T252 T249 arg1Of mice,specific
R181 T252 T250 arg1Of mice,A20
R182 T252 T251 arg1Of mice,knockout
R183 T252 T253 arg1Of mice,are
R184 T252 T254 arg2Of mice,protected
R185 T254 T245 arg1Of protected,Surprisingly
R186 T254 T246 arg1Of protected,","
R187 T254 T253 arg2Of protected,are
R188 T254 T255 arg1Of protected,against
R189 T258 T255 arg2Of infection,against
R19 T87 T98 arg1Of provides,by
R190 T258 T256 arg1Of infection,lethal
R191 T258 T257 arg1Of infection,IAV
R192 T260 T259 arg1Of results,These
R193 T260 T261 arg1Of results,challenge
R194 T264 T261 arg2Of belief,challenge
R195 T264 T262 arg1Of belief,the
R196 T264 T263 arg1Of belief,general
R197 T270 T266 arg1Of response,an
R198 T270 T267 arg1Of response,excessive
R199 T270 T268 arg1Of response,host
R2 T71 T70 arg2Of Tnfaip3,(
R20 T90 T87 arg2Of line,provides
R200 T270 T269 arg1Of response,proinflammatory
R201 T270 T271 arg1Of response,is
R202 T270 T272 arg2Of response,associated
R203 T270 T278 arg1Of response,suggest
R204 T272 T271 arg2Of associated,is
R205 T272 T273 arg1Of associated,with
R206 T272 T277 arg1Of associated,and
R207 T275 T273 arg2Of lethality,with
R208 T275 T274 arg1Of lethality,IAV-induced
R209 T277 T264 arg2Of and,belief
R21 T90 T88 arg1Of line,the
R210 T277 T265 arg1Of and,that
R211 T277 T276 arg1Of and,","
R212 T278 T277 arg2Of suggest,and
R213 T282 T280 arg2Of conditions,under
R214 T282 T281 arg1Of conditions,certain
R215 T283 T284 arg1Of inhibition,of
R216 T283 T286 arg1Of inhibition,might
R217 T283 T287 arg1Of inhibition,be
R218 T283 T288 arg1Of inhibition,of
R219 T285 T284 arg2Of A20,of
R22 T90 T89 arg1Of line,first
R220 T287 T278 arg2Of be,suggest
R221 T287 T279 arg1Of be,that
R222 T287 T280 arg1Of be,under
R223 T287 T286 arg2Of be,might
R224 T288 T287 arg2Of of,be
R225 T289 T288 arg2Of interest,of
R226 T289 T290 arg1Of interest,in
R227 T292 T290 arg2Of management,in
R228 T292 T291 arg1Of management,the
R229 T292 T293 arg1Of management,of
R23 T90 T91 arg1Of line,of
R230 T295 T293 arg2Of infections,of
R231 T295 T294 arg1Of infections,IAV
R24 T90 T93 arg1Of line,against
R25 T92 T91 arg2Of defense,of
R26 T94 T95 arg1Of viruses,and
R27 T95 T93 arg2Of and,against
R28 T97 T95 arg2Of pathogens,and
R29 T97 T96 arg1Of pathogens,other
R3 T72 T70 arg3Of ),(
R30 T99 T98 arg2Of responding,by
R31 T99 T100 arg1Of responding,to
R32 T103 T100 arg2Of molecules,to
R33 T103 T101 arg1Of molecules,specific
R3335 T5083 T5084 arg1Of A20,inhibits
R3336 T5086 T5085 arg1Of NF-κB,RIG-I-induced
R3337 T5086 T5087 arg1Of NF-κB,and
R3338 T5087 T5084 arg2Of and,inhibits
R3339 T5089 T5087 arg2Of activation,and
R3340 T5089 T5088 arg1Of activation,IRF3
R3341 T5091 T5090 arg1Of signaling,RIG-I
R3342 T5091 T5092 arg1Of signaling,induces
R3343 T5094 T5092 arg2Of activation,induces
R3344 T5094 T5093 arg1Of activation,the
R3345 T5094 T5095 arg1Of activation,of
R3346 T5096 T5097 arg1Of NF-κB,","
R3347 T5097 T5099 arg1Of ",",and
R3348 T5098 T5097 arg2Of IRF3,","
R3349 T5100 T5099 arg2Of IRF7,and
R3350 T5102 T5095 arg2Of factors,of
R3351 T5102 T5096 arg1Of factors,NF-κB
R3352 T5102 T5098 arg1Of factors,IRF3
R3353 T5102 T5100 arg1Of factors,IRF7
R3354 T5102 T5101 arg1Of factors,transcription
R3355 T5102 T5103 arg1Of factors,","
R3356 T5102 T5104 arg1Of factors,which
R3357 T5102 T5105 arg1Of factors,promote
R3358 T5107 T5105 arg2Of expression,promote
R3359 T5107 T5106 arg1Of expression,the
R3360 T5107 T5108 arg1Of expression,of
R3361 T5110 T5109 arg1Of cytokines,proinflammatory
R3362 T5110 T5111 arg1Of cytokines,and
R3363 T5111 T5108 arg2Of and,of
R3364 T5111 T5115 arg1Of and,that
R3365 T5111 T5116 arg1Of and,restrict
R3366 T5114 T5111 arg2Of IFNs,and
R3367 T5114 T5112 arg1Of IFNs,type
R3368 T5114 T5113 arg1Of IFNs,I
R3369 T5119 T5116 arg2Of propagation,restrict
R3370 T5119 T5117 arg1Of propagation,further
R3371 T5119 T5118 arg1Of propagation,viral
R3372 T5121 T5120 arg1Of studies,Previous
R3373 T5121 T5122 arg1Of studies,have
R3374 T5121 T5123 arg1Of studies,shown
R3375 T5123 T5122 arg2Of shown,have
R3376 T5126 T5125 arg1Of expressed,ectopically
R3377 T5127 T5126 arg1Of A20,expressed
R3378 T5127 T5129 arg1Of A20,regulates
R3379 T5129 T5123 arg2Of regulates,shown
R3380 T5129 T5124 arg1Of regulates,that
R3381 T5129 T5128 arg1Of regulates,negatively
R3382 T5129 T5134 arg1Of regulates,upon
R3383 T5129 T5137 arg1Of regulates,[
R3384 T5129 T5140 arg1Of regulates,–
R3385 T5129 T5141 arg1Of regulates,[
R3386 T5130 T5131 arg1Of NF-κB,and
R3387 T5132 T5131 arg2Of IRF3,and
R3388 T5133 T5129 arg2Of activation,regulates
R3389 T5133 T5130 arg1Of activation,NF-κB
R3390 T5133 T5132 arg1Of activation,IRF3
R3391 T5136 T5134 arg2Of stimulation,upon
R3392 T5136 T5135 arg1Of stimulation,RIG-I
R3393 T5138 T5137 arg2Of 50,[
R3394 T5139 T5137 arg3Of ],[
R3395 T5142 T5141 arg2Of 52,[
R3396 T5143 T5141 arg3Of ],[
R3397 T5146 T5147 arg1Of we,show
R3398 T5147 T5144 arg1Of show,Similarly
R3399 T5147 T5145 arg1Of show,","
R34 T103 T102 arg1Of molecules,microbial
R3400 T5150 T5149 arg1Of overexpression,A20
R3401 T5150 T5151 arg1Of overexpression,in
R3402 T5150 T5154 arg1Of overexpression,prevents
R3403 T5153 T5151 arg2Of cells,in
R3404 T5153 T5152 arg1Of cells,HEK293T
R3405 T5154 T5147 arg2Of prevents,show
R3406 T5154 T5148 arg1Of prevents,that
R3407 T5161 T5193 arg1Of activation,(
R3408 T5161 T5154 arg2Of activation,prevents
R3409 T5161 T5155 arg1Of activation,NF-κB-
R3410 T5161 T5156 arg1Of activation,and
R3411 T5161 T5157 arg1Of activation,IRF3-dependent
R3412 T5161 T5158 arg1Of activation,luciferase
R3413 T5161 T5159 arg1Of activation,reporter
R3414 T5161 T5160 arg1Of activation,gene
R3415 T5161 T5162 arg2Of activation,induced
R3416 T5161 T5177 arg1Of activation,corresponding
R3417 T5162 T5176 arg1Of induced,","
R3418 T5162 T5177 modOf induced,corresponding
R3419 T5164 T5162 arg1Of transfection,induced
R3420 T5164 T5163 arg2Of transfection,by
R3421 T5164 T5165 arg1Of transfection,of
R3422 T5169 T5168 arg1Of active,constitutive
R3423 T5170 T5165 arg2Of form,of
R3424 T5170 T5166 arg1Of form,a
R3425 T5170 T5167 arg2Of form,truncated
R3426 T5170 T5169 arg1Of form,active
R3427 T5170 T5171 arg1Of form,of
R3428 T5172 T5171 arg2Of RIG-I,of
R3429 T5172 T5173 arg1Of RIG-I,[
R3430 T5174 T5173 arg2Of 53,[
R3431 T5175 T5173 arg3Of ],[
R3432 T5177 T5178 arg1Of corresponding,to
R3433 T5184 T5178 arg2Of domains,to
R3434 T5184 T5179 arg1Of domains,only
R3435 T5184 T5180 arg1Of domains,the
R3436 T5184 T5181 arg1Of domains,two
R3437 T5184 T5182 arg1Of domains,N-terminal
R3438 T5184 T5183 arg1Of domains,CARD
R3439 T5184 T5185 arg1Of domains,of
R3440 T5184 T5187 arg1Of domains,[
R3441 T5186 T5185 arg2Of RIG-I,of
R3442 T5188 T5189 arg1Of RIG-I,(
R3443 T5188 T5187 arg2Of RIG-I,[
R3444 T5190 T5189 arg2Of 2CARD,(
R3445 T5191 T5189 arg3Of ),(
R3446 T5192 T5187 arg3Of ],[
R3447 T5195 T5194 arg1Of 1A,figure
R3448 T5195 T5196 arg1Of 1A,","
R3449 T5196 T5193 arg2Of ",",(
R3450 T5197 T5198 arg1Of left,and
R3451 T5199 T5198 arg2Of middle,and
R3452 T5200 T5196 arg2Of graph,","
R3453 T5200 T5197 arg1Of graph,left
R3454 T5200 T5199 arg1Of graph,middle
R3455 T5201 T5193 arg3Of ),(
R3456 T5202 T5204 arg1Of We,investigated
R3457 T5204 T5203 arg1Of investigated,next
R3458 T5206 T5208 arg1Of A20,inhibits
R3459 T5208 T5204 arg2Of inhibits,investigated
R3460 T5208 T5205 arg1Of inhibits,whether
R3461 T5208 T5207 arg1Of inhibits,also
R3462 T5210 T5208 arg2Of activation,inhibits
R3463 T5210 T5209 arg1Of activation,IRF7
R3464 T5212 T5211 arg2Of IRF3,Unlike
R3465 T5214 T5215 arg1Of IRF7,is
R3466 T5214 T5219 arg2Of IRF7,expressed
R3467 T5216 T5217 arg1Of not,or
R3468 T5218 T5217 arg2Of weakly,or
R3469 T5219 T5215 arg2Of expressed,is
R3470 T5219 T5216 arg1Of expressed,not
R3471 T5219 T5218 arg1Of expressed,weakly
R3472 T5219 T5220 arg1Of expressed,under
R3473 T5219 T5223 arg1Of expressed,and
R3474 T5222 T5220 arg2Of conditions,under
R3475 T5222 T5221 arg1Of conditions,naïve
R3476 T5223 T5211 arg1Of and,Unlike
R3477 T5223 T5213 arg1Of and,","
R3478 T5226 T5224 arg1Of levels,IRF7
R3479 T5226 T5225 arg1Of levels,protein
R3480 T5226 T5227 arg1Of levels,are
R3481 T5226 T5229 arg2Of levels,upregulated
R3482 T5229 T5223 arg2Of upregulated,and
R3483 T5229 T5227 arg2Of upregulated,are
R3484 T5229 T5228 arg1Of upregulated,rapidly
R3485 T5229 T5230 arg1Of upregulated,upon
R3486 T5229 T5237 arg1Of upregulated,","
R3487 T5229 T5238 arg1Of upregulated,[
R3488 T5233 T5230 arg2Of activation,upon
R3489 T5233 T5231 arg1Of activation,virus-induced
R3490 T5233 T5232 arg1Of activation,IRF3
R3491 T5233 T5234 arg1Of activation,[
R3492 T5235 T5234 arg2Of 54,[
R3493 T5236 T5234 arg3Of ],[
R3494 T5239 T5238 arg2Of 55,[
R3495 T5240 T5238 arg3Of ],[
R3496 T5242 T5241 arg1Of determine,To
R3497 T5244 T5242 arg2Of effect,determine
R3498 T5244 T5243 arg1Of effect,the
R3499 T5244 T5245 arg1Of effect,of
R35 T106 T104 arg1Of virus,Influenza
R3500 T5244 T5247 arg1Of effect,on
R3501 T5246 T5245 arg2Of A20,of
R3502 T5249 T5247 arg2Of activation,on
R3503 T5249 T5248 arg1Of activation,IRF7
R3504 T5251 T5253 arg1Of we,transfected
R3505 T5253 T5241 modOf transfected,To
R3506 T5253 T5250 arg1Of transfected,","
R3507 T5253 T5252 arg1Of transfected,therefore
R3508 T5253 T5261 arg1Of transfected,together
R3509 T5255 T5253 arg2Of amounts,transfected
R3510 T5255 T5254 arg1Of amounts,minor
R3511 T5255 T5256 arg1Of amounts,of
R3512 T5260 T5256 arg2Of plasmid,of
R3513 T5260 T5257 arg1Of plasmid,an
R3514 T5260 T5258 arg1Of plasmid,IRF7
R3515 T5260 T5259 arg1Of plasmid,expression
R3516 T5261 T5262 arg1Of together,with
R3517 T5263 T5262 arg2Of plasmids,with
R3518 T5263 T5264 arg1Of plasmids,encoding
R3519 T5265 T5266 arg1Of RIG-I,(
R3520 T5265 T5269 arg1Of RIG-I,","
R3521 T5267 T5266 arg2Of 2CARD,(
R3522 T5268 T5266 arg3Of ),(
R3523 T5269 T5271 arg1Of ",",and
R3524 T5270 T5269 arg2Of A20,","
R3525 T5271 T5264 arg2Of and,encoding
R3526 T5277 T5271 arg2Of construct,and
R3527 T5277 T5272 arg1Of construct,an
R3528 T5277 T5273 arg1Of construct,IRF7-specific
R3529 T5277 T5274 arg1Of construct,IFNα4
R3530 T5277 T5275 arg1Of construct,luciferase
R3531 T5277 T5276 arg1Of construct,reporter
R3532 T5278 T5279 arg1Of RIG-I,(
R3533 T5280 T5279 arg2Of 2CARD,(
R3534 T5281 T5279 arg3Of ),(
R3535 T5282 T5278 arg1Of expression,RIG-I
R3536 T5282 T5283 arg1Of expression,in
R3537 T5282 T5289 arg1Of expression,showed
R3538 T5285 T5283 arg2Of absence,in
R3539 T5285 T5284 arg1Of absence,the
R3540 T5285 T5286 arg1Of absence,of
R3541 T5288 T5286 arg2Of co-expression,of
R3542 T5288 T5287 arg1Of co-expression,IRF7
R3543 T5289 T5304 arg1Of showed,","
R3544 T5289 T5305 arg1Of showed,whereas
R3545 T5293 T5289 arg2Of activation,showed
R3546 T5293 T5290 arg1Of activation,negligible
R3547 T5293 T5291 arg1Of activation,IFNα4
R3548 T5293 T5292 arg1Of activation,promoter
R3549 T5293 T5294 arg1Of activation,(
R3550 T5296 T5294 arg2Of bar,(
R3551 T5296 T5295 arg1Of bar,grey
R3552 T5296 T5297 arg1Of bar,","
R3553 T5296 T5300 arg1Of bar,","
R3554 T5299 T5297 arg2Of 1A,","
R3555 T5299 T5298 arg1Of 1A,figure
R3556 T5302 T5300 arg2Of graph,","
R3557 T5302 T5301 arg1Of graph,right
R3558 T5303 T5294 arg3Of ),(
R3559 T5309 T5306 arg1Of expression,significant
R3560 T5309 T5307 arg1Of expression,reporter
R3561 T5309 T5308 arg1Of expression,gene
R3562 T5309 T5310 arg1Of expression,was
R3563 T5309 T5311 arg2Of expression,observed
R3564 T5311 T5305 arg2Of observed,whereas
R3565 T5311 T5310 arg2Of observed,was
R3566 T5311 T5312 arg1Of observed,in
R3567 T5314 T5312 arg2Of presence,in
R3568 T5314 T5313 arg1Of presence,the
R3569 T5314 T5315 arg1Of presence,of
R3570 T5316 T5315 arg2Of IRF7,of
R3571 T5317 T5318 arg1Of Similar,to
R3572 T5321 T5318 arg2Of effect,to
R3573 T5321 T5319 arg1Of effect,its
R3574 T5321 T5320 arg1Of effect,inhibitory
R3575 T5321 T5322 arg1Of effect,on
R3576 T5323 T5324 arg1Of NF-κB,and
R3577 T5325 T5324 arg2Of IRF3,and
R3578 T5326 T5322 arg2Of activation,on
R3579 T5326 T5323 arg1Of activation,NF-κB
R3580 T5326 T5325 arg1Of activation,IRF3
R3581 T5328 T5330 arg1Of A20,prevented
R3582 T5330 T5317 arg1Of prevented,Similar
R3583 T5330 T5327 arg1Of prevented,","
R3584 T5330 T5329 arg1Of prevented,also
R3585 T5333 T5330 arg2Of activation,prevented
R3586 T5333 T5331 arg1Of activation,RIG-I-induced
R3587 T5333 T5332 arg1Of activation,IRF7
R3588 T5333 T5334 arg1Of activation,(
R3589 T5336 T5334 arg2Of 1A,(
R3590 T5336 T5335 arg1Of 1A,figure
R3591 T5336 T5337 arg1Of 1A,","
R3592 T5339 T5337 arg2Of graph,","
R3593 T5339 T5338 arg1Of graph,right
R3594 T5340 T5334 arg3Of ),(
R3595 T5342 T5341 arg1Of results,These
R3596 T5342 T5343 arg1Of results,demonstrate
R3597 T5345 T5343 arg2Of potential,demonstrate
R3598 T5345 T5344 arg1Of potential,the
R3599 T5345 T5346 arg1Of potential,of
R36 T106 T105 arg1Of virus,A
R3600 T5345 T5348 modOf potential,to
R3601 T5347 T5346 arg2Of A20,of
R3602 T5349 T5348 arg1Of inhibit,to
R3603 T5351 T5350 arg1Of NF-κB,RIG-I-induced
R3604 T5351 T5352 arg1Of NF-κB,and
R3605 T5352 T5349 arg2Of and,inhibit
R3606 T5354 T5352 arg2Of activation,and
R3607 T5354 T5353 arg1Of activation,IRF3/7
R3608 T5356 T5355 arg1Of study,To
R3609 T5358 T5356 arg2Of effect,study
R3610 T5358 T5357 arg1Of effect,the
R3611 T5358 T5359 arg1Of effect,of
R3612 T5358 T5363 arg1Of effect,on
R3613 T5358 T5366 arg1Of effect,in
R3614 T5361 T5360 arg1Of expressed,endogenously
R3615 T5362 T5359 arg2Of A20,of
R3616 T5362 T5361 arg1Of A20,expressed
R3617 T5365 T5363 arg2Of signaling,on
R3618 T5365 T5364 arg1Of signaling,RIG-I-induced
R3619 T5369 T5368 arg1Of immunological,more
R3620 T5371 T5366 arg2Of context,in
R3621 T5371 T5367 arg1Of context,a
R3622 T5371 T5369 arg1Of context,immunological
R3623 T5371 T5370 arg1Of context,relevant
R3624 T5373 T5356 arg1Of we,study
R3625 T5373 T5374 arg1Of we,performed
R3626 T5374 T5355 modOf performed,To
R3627 T5374 T5372 arg1Of performed,","
R3628 T5376 T5374 arg2Of experiments,performed
R3629 T5376 T5375 arg1Of experiments,further
R3630 T5376 T5377 arg1Of experiments,in
R3631 T5381 T5377 arg2Of macrophages,in
R3632 T5381 T5378 arg1Of macrophages,A20
R3633 T5381 T5379 arg1Of macrophages,deficient
R3634 T5381 T5380 arg1Of macrophages,primary
R3635 T5386 T5383 arg1Of mice,A20
R3636 T5386 T5384 arg1Of mice,full
R3637 T5386 T5385 arg1Of mice,knockout
R3638 T5386 T5387 arg1Of mice,die
R3639 T5387 T5382 arg2Of die,Since
R3640 T5387 T5388 arg1Of die,prematurely
R3641 T5387 T5389 arg1Of die,as
R3642 T5391 T5389 arg2Of result,as
R3643 T5391 T5390 arg1Of result,a
R3644 T5391 T5392 arg1Of result,of
R3645 T5395 T5392 arg2Of inflammation,of
R3646 T5395 T5393 arg1Of inflammation,severe
R3647 T5395 T5394 arg1Of inflammation,multi-organ
R3648 T5395 T5396 arg1Of inflammation,[
R3649 T5397 T5396 arg2Of 37,[
R3650 T5398 T5396 arg3Of ],[
R3651 T5400 T5401 arg1Of we,generated
R3652 T5401 T5382 arg1Of generated,Since
R3653 T5401 T5399 arg1Of generated,","
R3654 T5402 T5401 arg2Of mice,generated
R3655 T5402 T5403 arg1Of mice,carrying
R3656 T5407 T5403 arg2Of allele,carrying
R3657 T5407 T5404 arg1Of allele,a
R3658 T5407 T5405 arg1Of allele,conditional
R3659 T5407 T5406 arg1Of allele,A20
R3660 T5407 T5408 arg2Of allele,in
R3661 T5407 T5409 arg1Of allele,which
R3662 T5410 T5411 arg1Of exon,IV
R3663 T5410 T5412 arg1Of exon,and
R3664 T5412 T5415 arg1Of and,were
R3665 T5412 T5416 arg2Of and,flanked
R3666 T5413 T5412 arg2Of exon,and
R3667 T5413 T5414 arg1Of exon,V
R3668 T5416 T5408 arg1Of flanked,in
R3669 T5416 T5415 arg2Of flanked,were
R3670 T5416 T5417 arg1Of flanked,by
R3671 T5420 T5417 arg2Of sites,by
R3672 T5420 T5418 arg1Of sites,two
R3673 T5420 T5419 arg1Of sites,loxP
R3674 T5420 T5421 arg1Of sites,[
R3675 T5422 T5421 arg2Of 56,[
R3676 T5423 T5421 arg3Of ],[
R3677 T5424 T5440 arg1Of Crossing,leads
R3678 T5424 T5448 arg1Of Crossing,allowed
R3679 T5426 T5424 arg2Of mice,Crossing
R3680 T5426 T5425 arg1Of mice,these
R3681 T5426 T5427 arg1Of mice,with
R3682 T5429 T5427 arg2Of mice,with
R3683 T5429 T5428 arg1Of mice,transgenic
R3684 T5429 T5430 arg1Of mice,expressing
R3685 T5430 T5433 arg1Of expressing,under
R3686 T5432 T5430 arg2Of recombinase,expressing
R3687 T5432 T5431 arg1Of recombinase,Cre
R3688 T5434 T5433 arg2Of control,under
R3689 T5434 T5435 arg1Of control,of
R3690 T5439 T5435 arg2Of promoter,of
R3691 T5439 T5436 arg1Of promoter,the
R3692 T5439 T5437 arg1Of promoter,lysozyme
R3693 T5439 T5438 arg1Of promoter,M
R3694 T5440 T5441 arg1Of leads,to
R3695 T5440 T5444 arg1Of leads,in
R3696 T5440 T5447 arg1Of leads,and
R3697 T5443 T5441 arg2Of deletion,to
R3698 T5443 T5442 arg1Of deletion,specific
R3699 T5446 T5444 arg2Of cells,in
R37 T106 T107 arg1Of virus,(
R3700 T5446 T5445 arg1Of cells,myeloid
R3701 T5448 T5447 arg2Of allowed,and
R3702 T5449 T5448 arg2Of us,allowed
R3703 T5449 T5451 arg1Of us,generate
R3704 T5451 T5448 arg3Of generate,allowed
R3705 T5451 T5450 arg1Of generate,to
R3706 T5457 T5451 arg2Of mice,generate
R3707 T5457 T5452 arg1Of mice,myeloid
R3708 T5457 T5453 arg1Of mice,cell
R3709 T5457 T5454 arg1Of mice,specific
R3710 T5457 T5455 arg1Of mice,A20
R3711 T5457 T5456 arg1Of mice,knockout
R3712 T5457 T5458 arg1Of mice,[
R3713 T5459 T5458 arg2Of 48,[
R3714 T5460 T5458 arg3Of ],[
R3715 T5462 T5461 arg1Of stimulate,To
R3716 T5465 T5462 arg2Of receptor,stimulate
R3717 T5465 T5463 arg1Of receptor,the
R3718 T5465 T5464 arg1Of receptor,RIG-I
R3719 T5467 T5462 arg1Of we,stimulate
R3720 T5467 T5468 arg1Of we,transfected
R3721 T5468 T5461 modOf transfected,To
R3722 T5468 T5466 arg1Of transfected,","
R3723 T5470 T5469 arg1Of BMDM,A20myel-KO
R3724 T5470 T5471 arg1Of BMDM,and
R3725 T5471 T5468 arg2Of and,transfected
R3726 T5471 T5476 arg1Of and,with
R3727 T5475 T5471 arg2Of cells,and
R3728 T5475 T5472 arg1Of cells,wild
R3729 T5475 T5473 arg1Of cells,type
R3730 T5475 T5474 arg1Of cells,control
R3731 T5478 T5476 arg2Of amounts,with
R3732 T5478 T5477 arg1Of amounts,minimal
R3733 T5478 T5479 arg1Of amounts,of
R3734 T5484 T5483 arg2Of LMW,(
R3735 T5485 T5483 arg3Of ),(
R3736 T5486 T5479 arg2Of poly,of
R3737 T5486 T5480 arg1Of poly,low
R3738 T5486 T5481 arg1Of poly,molecular
R3739 T5486 T5482 arg1Of poly,weight
R3740 T5486 T5483 arg1Of poly,(
R3741 T5486 T5487 arg1Of poly,(
R3742 T5486 T5492 arg1Of poly,","
R3743 T5486 T5493 arg1Of poly,which
R3744 T5486 T5494 arg1Of poly,is
R3745 T5486 T5495 arg2Of poly,known
R3746 T5486 T5498 arg1Of poly,bind
R3747 T5486 T5500 arg1Of poly,activate
R3748 T5488 T5487 arg2Of I,(
R3749 T5488 T5489 arg1Of I,:
R3750 T5488 T5490 arg1Of I,C
R3751 T5491 T5487 arg3Of ),(
R3752 T5495 T5494 arg2Of known,is
R3753 T5498 T5499 arg1Of bind,and
R3754 T5499 T5495 arg3Of and,known
R3755 T5499 T5496 arg1Of and,to
R3756 T5499 T5497 arg1Of and,preferentially
R3757 T5499 T5505 arg1Of and,[
R3758 T5500 T5499 arg2Of activate,and
R3759 T5501 T5503 arg1Of RIG-I,than
R3760 T5503 T5498 arg2Of than,bind
R3761 T5503 T5500 arg2Of than,activate
R3762 T5503 T5502 arg1Of than,rather
R3763 T5504 T5503 arg2Of MDA5,than
R3764 T5506 T5505 arg2Of 57,[
R3765 T5507 T5505 arg3Of ],[
R3766 T5509 T5508 arg2Of note,Of
R3767 T5512 T5511 arg1Of concentration,this
R3768 T5512 T5513 arg1Of concentration,of
R3769 T5512 T5520 arg1Of concentration,was
R3770 T5512 T5521 arg1Of concentration,unable
R3771 T5512 T5523 arg1Of concentration,induce
R3772 T5514 T5513 arg2Of poly,of
R3773 T5514 T5515 arg1Of poly,(
R3774 T5516 T5515 arg2Of I,(
R3775 T5516 T5517 arg1Of I,:
R3776 T5516 T5518 arg1Of I,C
R3777 T5519 T5515 arg3Of ),(
R3778 T5520 T5508 arg1Of was,Of
R3779 T5520 T5510 arg1Of was,","
R3780 T5521 T5520 arg2Of unable,was
R3781 T5523 T5521 arg2Of induce,unable
R3782 T5523 T5522 arg1Of induce,to
R3783 T5526 T5524 arg1Of dependent,significant
R3784 T5526 T5525 arg1Of dependent,TLR3
R3785 T5527 T5528 arg1Of NF-κB,and
R3786 T5529 T5528 arg2Of IRF3,and
R3787 T5530 T5526 arg1Of activation,dependent
R3788 T5530 T5527 arg1Of activation,NF-κB
R3789 T5530 T5529 arg1Of activation,IRF3
R3790 T5530 T5531 arg1Of activation,or
R3791 T5531 T5523 arg2Of or,induce
R3792 T5533 T5531 arg2Of production,or
R3793 T5533 T5532 arg1Of production,cytokine
R3794 T5533 T5534 arg1Of production,(
R3795 T5535 T5534 arg2Of data,(
R3796 T5535 T5537 arg2Of data,shown
R3797 T5537 T5536 arg1Of shown,not
R3798 T5538 T5534 arg3Of ),(
R3799 T5540 T5539 arg2Of expected,As
R38 T106 T110 arg1Of virus,produces
R3800 T5544 T5543 arg2Of I,(
R3801 T5544 T5545 arg1Of I,:
R3802 T5544 T5546 arg1Of I,C
R3803 T5547 T5543 arg3Of ),(
R3804 T5548 T5542 arg1Of transfection,poly
R3805 T5548 T5543 arg1Of transfection,(
R3806 T5548 T5549 arg1Of transfection,induced
R3807 T5549 T5539 arg1Of induced,As
R3808 T5549 T5541 arg1Of induced,","
R3809 T5552 T5549 arg2Of expression,induced
R3810 T5552 T5550 arg1Of expression,the
R3811 T5552 T5551 arg1Of expression,rapid
R3812 T5552 T5553 arg1Of expression,of
R3813 T5554 T5553 arg2Of A20,of
R3814 T5554 T5555 arg1Of A20,in
R3815 T5554 T5561 arg1Of A20,in
R3816 T5555 T5559 arg1Of in,but
R3817 T5557 T5555 arg2Of type,in
R3818 T5557 T5556 arg1Of type,wild
R3819 T5559 T5558 arg1Of but,","
R3820 T5561 T5559 arg2Of in,but
R3821 T5561 T5560 arg1Of in,not
R3822 T5563 T5561 arg2Of BMDM,in
R3823 T5563 T5562 arg1Of BMDM,A20myel-KO
R3824 T5563 T5564 arg1Of BMDM,(
R3825 T5566 T5564 arg2Of 1B,(
R3826 T5566 T5565 arg1Of 1B,figure
R3827 T5566 T5567 arg1Of 1B,","
R3828 T5569 T5567 arg2Of panel,","
R3829 T5569 T5568 arg1Of panel,upper
R3830 T5570 T5564 arg3Of ),(
R3831 T5574 T5571 arg2Of points,At
R3832 T5574 T5572 arg1Of points,early
R3833 T5574 T5573 arg1Of points,time
R3834 T5579 T5576 arg1Of forms,slightly
R3835 T5579 T5577 arg1Of forms,slower
R3836 T5579 T5578 arg1Of forms,migrating
R3837 T5579 T5580 arg1Of forms,of
R3838 T5579 T5582 arg1Of forms,were
R3839 T5579 T5583 arg2Of forms,observed
R3840 T5581 T5580 arg2Of A20,of
R3841 T5583 T5571 arg1Of observed,At
R3842 T5583 T5575 arg1Of observed,","
R3843 T5583 T5582 arg2Of observed,were
R3844 T5583 T5584 arg1Of observed,","
R3845 T5583 T5585 modOf observed,indicating
R3846 T5587 T5588 arg1Of A20,undergoes
R3847 T5588 T5585 arg2Of undergoes,indicating
R3848 T5588 T5586 arg1Of undergoes,that
R3849 T5588 T5593 arg1Of undergoes,upon
R3850 T5591 T5590 arg1Of unknown,yet
R3851 T5592 T5588 arg2Of modification,undergoes
R3852 T5592 T5589 arg1Of modification,a
R3853 T5592 T5591 arg1Of modification,unknown
R3854 T5594 T5595 arg1Of poly,(
R3855 T5596 T5595 arg2Of I,(
R3856 T5596 T5597 arg1Of I,:
R3857 T5596 T5598 arg1Of I,C
R3858 T5599 T5595 arg3Of ),(
R3859 T5600 T5593 arg2Of transfection,upon
R3860 T5600 T5594 arg1Of transfection,poly
R3861 T5602 T5601 arg2Of to,Compared
R3862 T5605 T5602 arg2Of BMBM,to
R3863 T5605 T5603 arg1Of BMBM,wild
R3864 T5605 T5604 arg1Of BMBM,type
R3865 T5609 T5607 arg1Of cells,A20
R3866 T5609 T5608 arg1Of cells,deficient
R3867 T5609 T5610 arg1Of cells,showed
R3868 T5610 T5601 arg1Of showed,Compared
R3869 T5610 T5606 arg1Of showed,","
R3870 T5610 T5614 arg1Of showed,as
R3871 T5613 T5610 arg2Of activation,showed
R3872 T5613 T5611 arg2Of activation,enhanced
R3873 T5613 T5612 arg1Of activation,NF-κB
R3874 T5615 T5614 arg2Of indicated,as
R3875 T5618 T5617 arg2Of phosphorylation,increased
R3876 T5618 T5619 arg1Of phosphorylation,and
R3877 T5619 T5615 arg1Of and,indicated
R3878 T5619 T5616 arg2Of and,by
R3879 T5619 T5622 arg1Of and,of
R3880 T5621 T5619 arg2Of degradation,and
R3881 T5621 T5620 arg1Of degradation,sustained
R3882 T5623 T5622 arg2Of IκBα,of
R3883 T5623 T5624 arg1Of IκBα,(
R3884 T5626 T5624 arg2Of 1B,(
R3885 T5626 T5625 arg1Of 1B,figure
R3886 T5627 T5624 arg3Of ),(
R3887 T5631 T5630 arg1Of translocation,nuclear
R3888 T5631 T5632 arg1Of translocation,of
R3889 T5631 T5637 arg1Of translocation,was
R3890 T5631 T5638 arg2Of translocation,enhanced
R3891 T5636 T5632 arg2Of subunit,of
R3892 T5636 T5633 arg1Of subunit,the
R3893 T5636 T5634 arg1Of subunit,p65
R3894 T5636 T5635 arg1Of subunit,NF-κB
R3895 T5638 T5628 arg1Of enhanced,Furthermore
R3896 T5638 T5629 arg1Of enhanced,","
R3897 T5638 T5637 arg2Of enhanced,was
R3898 T5638 T5639 arg1Of enhanced,in
R3899 T5638 T5649 arg1Of enhanced,","
R39 T108 T107 arg2Of IAV,(
R3900 T5640 T5641 arg1Of poly,(
R3901 T5642 T5641 arg2Of I,(
R3902 T5642 T5643 arg1Of I,:
R3903 T5642 T5644 arg1Of I,C
R3904 T5645 T5641 arg3Of ),(
R3905 T5648 T5639 arg2Of BMDM,in
R3906 T5648 T5640 arg1Of BMDM,poly
R3907 T5648 T5646 arg2Of BMDM,transfected
R3908 T5648 T5647 arg1Of BMDM,A20myel-KO
R3909 T5650 T5638 arg3Of reaching,enhanced
R3910 T5650 T5653 arg1Of reaching,at
R3911 T5652 T5650 arg2Of maximum,reaching
R3912 T5652 T5651 arg1Of maximum,a
R3913 T5656 T5653 arg2Of points,at
R3914 T5656 T5654 arg1Of points,earlier
R3915 T5656 T5655 arg1Of points,time
R3916 T5656 T5657 arg2Of points,compared
R3917 T5657 T5658 arg1Of compared,to
R3918 T5661 T5658 arg2Of cells,to
R3919 T5661 T5659 arg1Of cells,wild
R3920 T5661 T5660 arg1Of cells,type
R3921 T5661 T5662 arg1Of cells,(
R3922 T5664 T5662 arg2Of 1C,(
R3923 T5664 T5663 arg1Of 1C,figure
R3924 T5665 T5662 arg3Of ),(
R3925 T5666 T5667 arg1Of IRF3,is
R3926 T5666 T5668 arg2Of IRF3,known
R3927 T5666 T5670 arg1Of IRF3,be
R3928 T5666 T5671 arg2Of IRF3,activated
R3929 T5668 T5667 arg2Of known,is
R3930 T5671 T5668 arg3Of activated,known
R3931 T5671 T5669 arg1Of activated,to
R3932 T5671 T5670 arg2Of activated,be
R3933 T5671 T5672 arg1Of activated,upon
R3934 T5671 T5692 arg1Of activated,","
R3935 T5671 T5693 modOf activated,leading
R3936 T5671 T5703 arg1Of activated,[
R3937 T5673 T5672 arg2Of phosphorylation,upon
R3938 T5673 T5674 arg1Of phosphorylation,of
R3939 T5676 T5674 arg2Of series,of
R3940 T5676 T5675 arg1Of series,a
R3941 T5676 T5677 arg1Of series,of
R3942 T5676 T5682 arg1Of series,by
R3943 T5681 T5677 arg2Of residues,of
R3944 T5681 T5678 arg1Of residues,carboxyl
R3945 T5681 T5679 arg1Of residues,terminal
R3946 T5681 T5680 arg1Of residues,serine
R3947 T5685 T5683 arg1Of kinases,the
R3948 T5685 T5684 arg1Of kinases,IKK-like
R3949 T5686 T5685 arg1Of TBK1,kinases
R3950 T5686 T5687 arg1Of TBK1,and
R3951 T5687 T5682 arg2Of and,by
R3952 T5688 T5687 arg2Of IKKε,and
R3953 T5688 T5689 arg1Of IKKε,[
R3954 T5690 T5689 arg2Of 58,[
R3955 T5691 T5689 arg3Of ],[
R3956 T5693 T5694 arg1Of leading,to
R3957 T5696 T5697 arg1Of dimerization,and
R3958 T5697 T5694 arg2Of and,to
R3959 T5697 T5695 arg1Of and,its
R3960 T5697 T5700 arg1Of and,to
R3961 T5699 T5697 arg2Of translocation,and
R3962 T5699 T5698 arg1Of translocation,subsequent
R3963 T5702 T5700 arg2Of nucleus,to
R3964 T5702 T5701 arg1Of nucleus,the
R3965 T5704 T5703 arg2Of 59,[
R3966 T5705 T5703 arg3Of ],[
R3967 T5707 T5706 arg2Of immunoblotting,Using
R3968 T5707 T5708 arg1Of immunoblotting,with
R3969 T5710 T5708 arg2Of antibody,with
R3970 T5710 T5709 arg1Of antibody,an
R3971 T5710 T5711 arg2Of antibody,directed
R3972 T5711 T5712 arg1Of directed,against
R3973 T5714 T5712 arg2Of Ser396,against
R3974 T5714 T5713 arg2Of Ser396,phosphorylated
R3975 T5718 T5706 arg1Of phosphorylation,Using
R3976 T5718 T5716 arg1Of phosphorylation,maximum
R3977 T5718 T5717 arg1Of phosphorylation,IRF3
R3978 T5718 T5719 arg1Of phosphorylation,was
R3979 T5718 T5720 arg2Of phosphorylation,detected
R3980 T5720 T5706 modOf detected,Using
R3981 T5720 T5715 arg1Of detected,","
R3982 T5720 T5719 arg2Of detected,was
R3983 T5720 T5721 arg1Of detected,at
R3984 T5720 T5728 arg1Of detected,compared
R3985 T5724 T5721 arg2Of points,at
R3986 T5724 T5722 arg1Of points,earlier
R3987 T5724 T5723 arg1Of points,time
R3988 T5724 T5725 arg1Of points,in
R3989 T5727 T5725 arg2Of BMDM,in
R3990 T5727 T5726 arg1Of BMDM,A20myel-KO
R3991 T5729 T5728 arg2Of to,compared
R3992 T5732 T5729 arg2Of BMDM,to
R3993 T5732 T5730 arg1Of BMDM,wild
R3994 T5732 T5731 arg1Of BMDM,type
R3995 T5732 T5733 arg1Of BMDM,(
R3996 T5735 T5733 arg2Of 1B,(
R3997 T5735 T5734 arg1Of 1B,figure
R3998 T5736 T5733 arg3Of ),(
R3999 T5737 T5738 arg1Of Similar,to
R4 T73 T69 arg1Of Deficiency,A20
R40 T109 T107 arg3Of ),(
R4000 T5739 T5738 arg2Of p65,to
R4001 T5743 T5741 arg1Of translocation,IRF3
R4002 T5743 T5742 arg1Of translocation,nuclear
R4003 T5743 T5744 arg1Of translocation,reached
R4004 T5744 T5737 arg1Of reached,Similar
R4005 T5744 T5740 arg1Of reached,","
R4006 T5744 T5747 arg1Of reached,at
R4007 T5744 T5756 arg1Of reached,compared
R4008 T5746 T5744 arg2Of maximum,reached
R4009 T5746 T5745 arg1Of maximum,its
R4010 T5749 T5750 arg1Of earlier,time
R4011 T5751 T5747 arg2Of point,at
R4012 T5751 T5748 arg1Of point,an
R4013 T5751 T5749 arg1Of point,earlier
R4014 T5751 T5752 arg1Of point,in
R4015 T5755 T5752 arg2Of BMDM,in
R4016 T5755 T5753 arg1Of BMDM,A20
R4017 T5755 T5754 arg1Of BMDM,deficient
R4018 T5757 T5756 arg2Of to,compared
R4019 T5760 T5757 arg2Of cells,to
R4020 T5760 T5758 arg1Of cells,wild
R4021 T5760 T5759 arg1Of cells,type
R4022 T5760 T5761 arg1Of cells,(
R4023 T5763 T5761 arg2Of 1C,(
R4024 T5763 T5762 arg1Of 1C,figure
R4025 T5764 T5761 arg3Of ),(
R4026 T5765 T5766 arg1Of NF-κB,controls
R4027 T5766 T5774 arg1Of controls,and
R4028 T5768 T5766 arg2Of expression,controls
R4029 T5768 T5767 arg1Of expression,the
R4030 T5768 T5769 arg1Of expression,of
R4031 T5770 T5771 arg1Of IL-6,and
R4032 T5771 T5769 arg2Of and,of
R4033 T5772 T5771 arg2Of TNF,and
R4034 T5774 T5773 arg1Of and,","
R4035 T5775 T5776 arg1Of NF-κB,and
R4036 T5776 T5778 arg1Of and,control
R4037 T5777 T5776 arg2Of IRF3,and
R4038 T5778 T5774 arg2Of control,and
R4039 T5780 T5778 arg2Of expression,control
R4040 T5780 T5779 arg1Of expression,the
R4041 T5780 T5781 arg1Of expression,of
R4042 T5782 T5781 arg2Of IFNβ,of
R4043 T5784 T5783 arg2Of line,In
R4044 T5784 T5785 arg1Of line,with
R4045 T5788 T5785 arg2Of activation,with
R4046 T5788 T5786 arg1Of activation,the
R4047 T5788 T5787 arg2Of activation,enhanced
R4048 T5788 T5789 arg1Of activation,of
R4049 T5788 T5793 arg1Of activation,as
R4050 T5790 T5791 arg1Of NF-κB,and
R4051 T5791 T5789 arg2Of and,of
R4052 T5792 T5791 arg2Of IRF3,and
R4053 T5794 T5793 arg2Of described,as
R4054 T5794 T5795 arg1Of described,above
R4055 T5798 T5797 arg1Of BMDM,A20myel-KO
R4056 T5798 T5799 arg1Of BMDM,secreted
R4057 T5799 T5783 arg1Of secreted,In
R4058 T5799 T5796 arg1Of secreted,","
R4059 T5801 T5799 arg2Of amounts,secreted
R4060 T5801 T5800 arg2Of amounts,increased
R4061 T5801 T5802 arg1Of amounts,of
R4062 T5803 T5804 arg1Of IL-6,","
R4063 T5804 T5806 arg1Of ",",and
R4064 T5805 T5804 arg2Of TNF,","
R4065 T5806 T5802 arg2Of and,of
R4066 T5807 T5806 arg2Of IFNβ,and
R4067 T5807 T5808 arg1Of IFNβ,(
R4068 T5810 T5808 arg2Of 1D,(
R4069 T5810 T5809 arg1Of 1D,figure
R4070 T5811 T5808 arg3Of ),(
R4071 T5813 T5812 arg1Of results,Similar
R4072 T5813 T5814 arg1Of results,were
R4073 T5813 T5815 arg2Of results,obtained
R4074 T5815 T5814 arg2Of obtained,were
R4075 T5815 T5816 modOf obtained,using
R4076 T5818 T5816 arg2Of macrophages,using
R4077 T5818 T5817 arg1Of macrophages,peritoneal
R4078 T5818 T5819 arg1Of macrophages,(
R4079 T5820 T5819 arg2Of data,(
R4080 T5820 T5822 arg2Of data,shown
R4081 T5822 T5821 arg1Of shown,not
R4082 T5823 T5819 arg3Of ),(
R4083 T5827 T5826 arg1Of results,these
R4084 T5827 T5828 arg1Of results,demonstrate
R4085 T5828 T5824 arg1Of demonstrate,Together
R4086 T5828 T5825 arg1Of demonstrate,","
R4087 T5830 T5831 arg1Of A20,plays
R4088 T5831 T5828 arg2Of plays,demonstrate
R4089 T5831 T5829 arg1Of plays,that
R4090 T5831 T5835 arg1Of plays,in
R4091 T5834 T5831 arg2Of role,plays
R4092 T5834 T5832 arg1Of role,an
R4093 T5834 T5833 arg1Of role,important
R4094 T5838 T5835 arg2Of regulation,in
R4095 T5838 T5836 arg1Of regulation,the
R4096 T5838 T5837 arg1Of regulation,negative
R4097 T5838 T5839 arg1Of regulation,of
R4098 T5841 T5842 arg1Of NF-κB,and
R4099 T5843 T5842 arg2Of IRF3,and
R41 T110 T113 arg1Of produces,as
R4100 T5844 T5839 arg2Of activation,of
R4101 T5844 T5840 arg1Of activation,RIG-I-induced
R4102 T5844 T5841 arg1Of activation,NF-κB
R4103 T5844 T5843 arg1Of activation,IRF3
R4104 T5844 T5845 arg1Of activation,in
R4105 T5847 T5845 arg2Of macrophages,in
R4106 T5847 T5846 arg1Of macrophages,primary
R42 T112 T110 arg2Of RNA,produces
R43 T112 T111 arg1Of RNA,double-stranded
R44 T115 T113 arg2Of intermediate,as
R45 T115 T114 arg1Of intermediate,an
R46 T115 T116 arg1Of intermediate,during
R47 T120 T116 arg2Of cycle,during
R48 T120 T117 arg1Of cycle,the
R49 T120 T118 arg1Of cycle,replication
R5 T73 T74 arg1Of Deficiency,in
R50 T120 T119 arg1Of cycle,life
R51 T120 T121 arg1Of cycle,","
R52 T120 T122 arg1Of cycle,which
R53 T120 T123 arg1Of cycle,activates
R54 T120 T131 arg1Of cycle,induces
R5449 T7810 T7812 arg1Of A20,regulates
R5450 T7812 T7811 arg1Of regulates,negatively
R5451 T7815 T7812 arg2Of expression,regulates
R5452 T7815 T7813 arg1Of expression,IAV-induced
R5453 T7815 T7814 arg1Of expression,gene
R5454 T7815 T7816 arg1Of expression,in
R5455 T7817 T7816 arg2Of BMDM,in
R5456 T7819 T7818 arg1Of investigate,To
R5457 T7821 T7819 arg2Of role,investigate
R5458 T7821 T7820 arg1Of role,the
R5459 T7821 T7822 arg1Of role,of
R5460 T7821 T7824 arg1Of role,in
R5461 T7823 T7822 arg2Of A20,of
R5462 T7827 T7826 arg1Of proinflammatory,IAV-induced
R5463 T7827 T7828 arg1Of proinflammatory,and
R5464 T7831 T7828 arg2Of immune,and
R5465 T7831 T7829 arg1Of immune,antiviral
R5466 T7831 T7830 arg1Of immune,innate
R5467 T7832 T7824 arg2Of responses,in
R5468 T7832 T7825 arg1Of responses,the
R5469 T7832 T7827 arg1Of responses,proinflammatory
R5470 T7832 T7831 arg1Of responses,immune
R5471 T7834 T7819 arg1Of we,investigate
R5472 T7834 T7835 arg1Of we,infected
R5473 T7835 T7818 modOf infected,To
R5474 T7835 T7833 arg1Of infected,","
R5475 T7836 T7837 arg1Of A20,deficient
R5476 T7836 T7838 arg1Of A20,and
R5477 T7838 T7835 arg2Of and,infected
R5478 T7838 T7841 arg1Of and,with
R5479 T7840 T7838 arg2Of BMDM,and
R5480 T7840 T7839 arg1Of BMDM,control
R5481 T7843 T7841 arg2Of X-47,with
R5482 T7843 T7842 arg1Of X-47,IAV
R5483 T7843 T7844 arg1Of X-47,(
R5484 T7845 T7844 arg2Of H3N2,(
R5485 T7846 T7844 arg3Of ),(
R5486 T7849 T7847 arg1Of levels,A20
R5487 T7849 T7848 arg1Of levels,mRNA
R5488 T7849 T7850 arg1Of levels,were
R5489 T7849 T7852 arg2Of levels,induced
R5490 T7852 T7850 arg2Of induced,were
R5491 T7852 T7851 arg1Of induced,rapidly
R5492 T7852 T7853 arg1Of induced,in
R5493 T7852 T7860 arg1Of induced,in
R5494 T7852 T7864 arg1Of induced,","
R5495 T7852 T7865 arg1Of induced,upon
R5496 T7853 T7858 arg1Of in,but
R5497 T7856 T7853 arg2Of BMDM,in
R5498 T7856 T7854 arg1Of BMDM,wild
R5499 T7856 T7855 arg1Of BMDM,type
R55 T123 T130 arg1Of activates,and
R5500 T7858 T7857 arg1Of but,","
R5501 T7860 T7858 arg2Of in,but
R5502 T7860 T7859 arg1Of in,not
R5503 T7863 T7860 arg2Of BMDM,in
R5504 T7863 T7861 arg1Of BMDM,A20
R5505 T7863 T7862 arg1Of BMDM,deficient
R5506 T7867 T7865 arg2Of infection,upon
R5507 T7867 T7866 arg1Of infection,viral
R5508 T7867 T7868 arg1Of infection,(
R5509 T7870 T7868 arg2Of 2A,(
R5510 T7870 T7869 arg1Of 2A,figure
R5511 T7871 T7868 arg3Of ),(
R5512 T7875 T7874 arg1Of BMDM,A20myel-KO
R5513 T7875 T7876 arg1Of BMDM,show
R5514 T7876 T7872 arg1Of show,Furthermore
R5515 T7876 T7873 arg1Of show,","
R5516 T7876 T7887 arg1Of show,compared
R5517 T7878 T7876 arg2Of expression,show
R5518 T7878 T7877 arg2Of expression,enhanced
R5519 T7878 T7879 arg1Of expression,of
R5520 T7878 T7884 arg1Of expression,after
R5521 T7880 T7881 arg1Of IL-6,and
R5522 T7882 T7881 arg2Of IFNβ,and
R5523 T7883 T7879 arg2Of mRNA,of
R5524 T7883 T7880 arg1Of mRNA,IL-6
R5525 T7883 T7882 arg1Of mRNA,IFNβ
R5526 T7886 T7884 arg2Of infection,after
R5527 T7886 T7885 arg1Of infection,IAV
R5528 T7888 T7887 arg2Of to,compared
R5529 T7890 T7888 arg2Of cells,to
R5530 T7890 T7889 arg1Of cells,control
R5531 T7890 T7891 arg1Of cells,(
R5532 T7893 T7891 arg2Of 2A,(
R5533 T7893 T7892 arg1Of 2A,figure
R5534 T7894 T7891 arg3Of ),(
R5535 T7896 T7895 arg2Of accordance,In
R5536 T7896 T7897 arg1Of accordance,with
R5537 T7899 T7897 arg2Of data,with
R5538 T7899 T7898 arg1Of data,these
R5539 T7903 T7901 arg1Of supernatant,cell
R5540 T7903 T7902 arg1Of supernatant,culture
R5541 T7903 T7904 arg2Of supernatant,collected
R5542 T7903 T7908 arg1Of supernatant,contained
R5543 T7904 T7905 arg1Of collected,from
R5544 T7907 T7905 arg2Of cells,from
R5545 T7907 T7906 arg1Of cells,these
R5546 T7908 T7895 arg1Of contained,In
R5547 T7908 T7900 arg1Of contained,","
R5548 T7910 T7908 arg2Of levels,contained
R5549 T7910 T7909 arg1Of levels,higher
R5550 T7910 T7911 arg1Of levels,of
R5551 T7912 T7913 arg1Of TNF,and
R5552 T7913 T7911 arg2Of and,of
R5553 T7913 T7915 arg1Of and,(
R5554 T7914 T7913 arg2Of IFNβ,and
R5555 T7917 T7915 arg2Of 2B,(
R5556 T7917 T7916 arg1Of 2B,figure
R5557 T7918 T7915 arg3Of ),(
R5558 T7921 T7919 arg2Of infection,Upon
R5559 T7921 T7920 arg1Of infection,host
R5560 T7921 T7922 arg1Of infection,with
R5561 T7923 T7922 arg2Of IAV,with
R5562 T7926 T7925 arg1Of macrophages,alveolar
R5563 T7926 T7927 arg1Of macrophages,are
R5564 T7926 T7936 arg1Of macrophages,attracting
R5565 T7927 T7919 arg1Of are,Upon
R5566 T7927 T7924 arg1Of are,","
R5567 T7927 T7935 arg1Of are,","
R5568 T7927 T7936 modOf are,attracting
R5569 T7930 T7927 arg2Of source,are
R5570 T7930 T7928 arg1Of source,an
R5571 T7930 T7929 arg1Of source,important
R5572 T7930 T7931 arg1Of source,of
R5573 T7932 T7933 arg1Of cytokines,and
R5574 T7933 T7931 arg2Of and,of
R5575 T7934 T7933 arg2Of chemokines,and
R5576 T7936 T7940 arg1Of attracting,to
R5577 T7936 T7943 arg1Of attracting,during
R5578 T7939 T7936 arg2Of cells,attracting
R5579 T7939 T7937 arg1Of cells,innate
R5580 T7939 T7938 arg1Of cells,immune
R5581 T7942 T7940 arg2Of lung,to
R5582 T7942 T7941 arg1Of lung,the
R5583 T7946 T7943 arg2Of phase,during
R5584 T7946 T7944 arg1Of phase,the
R5585 T7946 T7945 arg1Of phase,primary
R5586 T7946 T7947 arg1Of phase,of
R5587 T7948 T7947 arg2Of infection,of
R5588 T7950 T7949 arg1Of test,To
R5589 T7952 T7954 arg1Of A20,controls
R5590 T7954 T7950 arg2Of controls,test
R5591 T7954 T7951 arg1Of controls,whether
R5592 T7954 T7953 arg1Of controls,directly
R5593 T7957 T7954 arg2Of expression,controls
R5594 T7957 T7955 arg1Of expression,IAV-induced
R5595 T7957 T7956 arg1Of expression,gene
R5596 T7957 T7958 arg1Of expression,in
R5597 T7960 T7958 arg2Of macrophages,in
R5598 T7960 T7959 arg1Of macrophages,alveolar
R5599 T7962 T7950 arg1Of we,test
R56 T129 T123 arg2Of RIG-I,activates
R5600 T7962 T7963 arg1Of we,isolated
R5601 T7962 T7974 arg1Of we,infected
R5602 T7963 T7973 arg1Of isolated,and
R5603 T7965 T7963 arg2Of cells,isolated
R5604 T7965 T7964 arg1Of cells,these
R5605 T7965 T7966 arg1Of cells,from
R5606 T7967 T7966 arg2Of lungs,from
R5607 T7967 T7968 arg1Of lungs,of
R5608 T7969 T7970 arg1Of A20myel-KO,and
R5609 T7971 T7970 arg2Of control,and
R5610 T7972 T7968 arg2Of littermates,of
R5611 T7972 T7969 arg1Of littermates,A20myel-KO
R5612 T7972 T7971 arg1Of littermates,control
R5613 T7973 T7949 modOf and,To
R5614 T7973 T7961 arg1Of and,","
R5615 T7974 T7973 arg2Of infected,and
R5616 T7974 T7977 arg1Of infected,vitro
R5617 T7974 T7978 arg1Of infected,with
R5618 T7975 T7974 arg2Of them,infected
R5619 T7977 T7976 arg1Of vitro,in
R5620 T7980 T7978 arg2Of X-47,with
R5621 T7980 T7979 arg1Of X-47,IAV
R5622 T7981 T7982 arg1Of Expression,and
R5623 T7982 T7984 arg1Of and,of
R5624 T7982 T8005 arg1Of and,and
R5625 T7983 T7982 arg2Of secretion,and
R5626 T7987 T7985 arg1Of cytokines,the
R5627 T7987 T7986 arg1Of cytokines,proinflammatory
R5628 T7988 T7989 arg1Of IL-6,and
R5629 T7989 T7984 arg2Of and,of
R5630 T7989 T7987 arg1Of and,cytokines
R5631 T7989 T7991 arg1Of and,","
R5632 T7990 T7989 arg2Of TNF,and
R5633 T7995 T7996 arg1Of IFNβ,and
R5634 T7996 T7992 arg1Of and,the
R5635 T7996 T7993 arg1Of and,type-I
R5636 T7996 T7994 arg1Of and,IFN
R5637 T7996 T7998 arg1Of and,and
R5638 T7997 T7996 arg2Of IFNα4,and
R5639 T7998 T7991 arg2Of and,","
R5640 T8001 T7998 arg2Of MCP-1,and
R5641 T8001 T7999 arg1Of MCP-1,the
R5642 T8001 T8000 arg1Of MCP-1,chemokines
R5643 T8001 T8002 arg1Of MCP-1,(
R5644 T8003 T8002 arg2Of ccl2,(
R5645 T8004 T8002 arg3Of ),(
R5646 T8005 T8010 arg1Of and,was
R5647 T8005 T8012 arg1Of and,higher
R5648 T8006 T8005 arg2Of KC,and
R5649 T8006 T8007 arg1Of KC,(
R5650 T8008 T8007 arg2Of cxcl1,(
R5651 T8009 T8007 arg3Of ),(
R5652 T8012 T8010 arg2Of higher,was
R5653 T8012 T8011 arg1Of higher,significantly
R5654 T8012 T8013 arg1Of higher,in
R5655 T8016 T8013 arg2Of cells,in
R5656 T8016 T8014 arg1Of cells,IAV
R5657 T8016 T8015 arg1Of cells,infected
R5658 T8016 T8017 arg1Of cells,lacking
R5659 T8017 T8019 arg1Of lacking,compared
R5660 T8018 T8017 arg2Of A20,lacking
R5661 T8020 T8019 arg2Of to,compared
R5662 T8024 T8020 arg2Of cells,to
R5663 T8024 T8021 arg1Of cells,infected
R5664 T8024 T8022 arg1Of cells,wild
R5665 T8024 T8023 arg1Of cells,type
R5666 T8024 T8025 arg1Of cells,(
R5667 T8027 T8026 arg1Of 2C,figure
R5668 T8027 T8028 arg1Of 2C,and
R5669 T8028 T8025 arg2Of and,(
R5670 T8030 T8028 arg2Of S1,and
R5671 T8030 T8029 arg1Of S1,figure
R5672 T8031 T8025 arg3Of ),(
R5673 T8032 T8033 arg1Of Taken,together
R5674 T8035 T8034 arg1Of results,these
R5675 T8035 T8036 arg1Of results,demonstrate
R5676 T8036 T8032 modOf demonstrate,Taken
R5677 T8038 T8040 arg1Of A20,regulates
R5678 T8040 T8036 arg2Of regulates,demonstrate
R5679 T8040 T8037 arg1Of regulates,that
R5680 T8040 T8039 arg1Of regulates,negatively
R5681 T8040 T8050 arg1Of regulates,","
R5682 T8040 T8051 arg1Of regulates,consistent
R5683 T8042 T8043 arg1Of proinflammatory,and
R5684 T8044 T8043 arg2Of antiviral,and
R5685 T8046 T8040 arg2Of expression,regulates
R5686 T8046 T8041 arg1Of expression,IAV-induced
R5687 T8046 T8042 arg1Of expression,proinflammatory
R5688 T8046 T8044 arg1Of expression,antiviral
R5689 T8046 T8045 arg1Of expression,gene
R5690 T8046 T8047 arg1Of expression,in
R5691 T8049 T8047 arg2Of macrophages,in
R5692 T8049 T8048 arg1Of macrophages,alveolar
R5693 T8051 T8052 arg1Of consistent,with
R5694 T8055 T8052 arg2Of effect,with
R5695 T8055 T8053 arg1Of effect,the
R5696 T8055 T8054 arg1Of effect,inhibitory
R5697 T8055 T8056 arg1Of effect,of
R5698 T8057 T8056 arg2Of A20,of
R5699 T8057 T8058 arg2Of A20,seen
R57 T129 T124 arg1Of RIG-I,the
R5700 T8058 T8059 arg1Of seen,on
R5701 T8061 T8060 arg1Of NF-κB,RIG-I-induced
R5702 T8061 T8062 arg1Of NF-κB,and
R5703 T8062 T8059 arg2Of and,on
R5704 T8064 T8062 arg2Of activation,and
R5705 T8064 T8063 arg1Of activation,IRF3
R58 T129 T125 arg1Of RIG-I,intracellular
R59 T129 T126 arg1Of RIG-I,pathogen
R6 T73 T78 arg1Of Deficiency,against
R60 T129 T127 arg1Of RIG-I,recognition
R609 T1339 T1340 arg1Of Viruses,are
R61 T129 T128 arg1Of RIG-I,receptor
R610 T1342 T1340 arg2Of class,are
R611 T1342 T1341 arg1Of class,a
R612 T1342 T1343 arg1Of class,of
R613 T1345 T1344 arg1Of diverse,highly
R6139 T8927 T8926 arg1Of deficiency,A20
R614 T1346 T1343 arg2Of pathogens,of
R6140 T8927 T8928 arg1Of deficiency,in
R6141 T8927 T8931 arg1Of deficiency,protects
R6142 T8930 T8928 arg2Of cells,in
R6143 T8930 T8929 arg1Of cells,myeloid
R6144 T8931 T8932 arg1Of protects,against
R6145 T8935 T8932 arg2Of infection,against
R6146 T8935 T8933 arg1Of infection,IAV
R6147 T8935 T8934 arg1Of infection,lung
R6148 T8937 T8936 arg1Of determine,To
R6149 T8937 T8946 arg1Of determine,during
R615 T1346 T1345 arg1Of pathogens,diverse
R6150 T8937 T8951 arg1Of determine,vivo
R6151 T8939 T8937 arg2Of role,determine
R6152 T8939 T8938 arg1Of role,the
R6153 T8939 T8940 arg1Of role,of
R6154 T8939 T8943 arg1Of role,in
R6155 T8942 T8940 arg2Of expression,of
R6156 T8942 T8941 arg1Of expression,A20
R6157 T8945 T8943 arg2Of cells,in
R6158 T8945 T8944 arg1Of cells,myeloid
R6159 T8949 T8946 arg2Of infection,during
R616 T1346 T1347 arg1Of pathogens,which
R6160 T8949 T8947 arg1Of infection,an
R6161 T8949 T8948 arg1Of infection,IAV
R6162 T8951 T8950 arg1Of vivo,in
R6163 T8953 T8937 arg1Of we,determine
R6164 T8953 T8955 arg1Of we,inoculated
R6165 T8955 T8936 modOf inoculated,To
R6166 T8955 T8952 arg1Of inoculated,","
R6167 T8955 T8954 arg1Of inoculated,intranasally
R6168 T8955 T8979 arg1Of inoculated,in
R6169 T8958 T8957 arg1Of mice,A20myel-KO
R617 T1346 T1348 arg1Of pathogens,depend
R6170 T8958 T8959 arg1Of mice,and
R6171 T8959 T8955 arg2Of and,inoculated
R6172 T8959 T8956 arg1Of and,both
R6173 T8959 T8962 arg1Of and,with
R6174 T8959 T8969 arg2Of and,adapted
R6175 T8961 T8959 arg2Of littermates,and
R6176 T8961 T8960 arg1Of littermates,control
R6177 T8965 T8962 arg2Of dose,with
R6178 T8965 T8963 arg1Of dose,a
R6179 T8965 T8964 arg1Of dose,sublethal
R618 T1348 T1349 arg1Of depend,on
R6180 T8965 T8966 arg1Of dose,of
R6181 T8968 T8966 arg2Of mouse,of
R6182 T8968 T8967 arg1Of mouse,the
R6183 T8973 T8972 arg2Of H3N2,(
R6184 T8974 T8972 arg3Of ),(
R6185 T8975 T8970 arg1Of strain,IAV
R6186 T8975 T8971 arg1Of strain,X-47
R6187 T8975 T8972 arg1Of strain,(
R6188 T8975 T8976 arg1Of strain,and
R6189 T8976 T8969 arg3Of and,adapted
R619 T1352 T1349 arg2Of cell,on
R6190 T8978 T8976 arg2Of morbidity,and
R6191 T8978 T8977 arg2Of morbidity,monitored
R6192 T8980 T8979 arg2Of terms,in
R6193 T8980 T8981 arg1Of terms,of
R6194 T8983 T8981 arg2Of loss,of
R6195 T8983 T8982 arg1Of loss,weight
R6196 T8985 T8984 arg1Of mice,A20myel-KO
R6197 T8985 T8986 arg1Of mice,showed
R6198 T8985 T8997 arg1Of mice,recovered
R6199 T8986 T8990 arg1Of showed,compared
R62 T131 T130 arg2Of induces,and
R620 T1352 T1350 arg1Of cell,the
R6200 T8986 T8996 arg1Of showed,and
R6201 T8989 T8986 arg2Of loss,showed
R6202 T8989 T8987 arg2Of loss,reduced
R6203 T8989 T8988 arg1Of loss,weight
R6204 T8991 T8990 arg2Of to,compared
R6205 T8995 T8991 arg2Of littermates,to
R6206 T8995 T8992 arg1Of littermates,wild
R6207 T8995 T8993 arg1Of littermates,type
R6208 T8995 T8994 arg1Of littermates,control
R6209 T8997 T8996 arg2Of recovered,and
R621 T1352 T1351 arg1Of cell,host
R6210 T8997 T8998 arg1Of recovered,faster
R6211 T8997 T8999 arg1Of recovered,from
R6212 T9002 T8999 arg2Of challenge,from
R6213 T9002 T9000 arg1Of challenge,the
R6214 T9002 T9001 arg1Of challenge,viral
R6215 T9002 T9003 arg1Of challenge,(
R6216 T9005 T9003 arg2Of 3A,(
R6217 T9005 T9004 arg1Of 3A,figure
R6218 T9006 T9003 arg3Of ),(
R6219 T9011 T9009 arg1Of concentration,total
R622 T1352 T1353 arg1Of cell,for
R6220 T9011 T9010 arg1Of concentration,protein
R6221 T9011 T9012 arg1Of concentration,in
R6222 T9011 T9015 arg1Of concentration,","
R6223 T9011 T9016 arg1Of concentration,which
R6224 T9011 T9017 arg1Of concentration,reflects
R6225 T9011 T9024 arg1Of concentration,was
R6226 T9011 T9025 arg2Of concentration,increased
R6227 T9011 T9032 arg1Of concentration,post
R6228 T9011 T9043 arg1Of concentration,was
R6229 T9011 T9045 arg1Of concentration,lower
R623 T1355 T1353 arg2Of replication,for
R6230 T9014 T9012 arg2Of fluid,in
R6231 T9014 T9013 arg1Of fluid,BAL
R6232 T9017 T9023 arg1Of reflects,","
R6233 T9019 T9018 arg1Of damage,lung
R6234 T9019 T9020 arg1Of damage,and
R6235 T9020 T9017 arg2Of and,reflects
R6236 T9022 T9020 arg2Of leakage,and
R6237 T9022 T9021 arg1Of leakage,vascular
R6238 T9025 T9023 arg2Of increased,","
R6239 T9025 T9024 arg2Of increased,was
R624 T1355 T1354 arg1Of replication,their
R6240 T9025 T9026 arg1Of increased,significantly
R6241 T9025 T9027 arg1Of increased,at
R6242 T9028 T9029 arg1Of 7,and
R6243 T9030 T9029 arg2Of 10,and
R6244 T9031 T9027 arg2Of days,at
R6245 T9031 T9028 arg1Of days,7
R6246 T9031 T9030 arg1Of days,10
R6247 T9032 T9034 arg1Of post,in
R6248 T9032 T9042 arg1Of post,and
R6249 T9033 T9032 arg2Of infection,post
R625 T1357 T1356 arg1Of initiation,The
R6250 T9037 T9038 arg1Of type,and
R6251 T9039 T9038 arg2Of A20myel-KO,and
R6252 T9040 T9034 arg2Of mice,in
R6253 T9040 T9035 arg1Of mice,both
R6254 T9040 T9036 arg1Of mice,wild
R6255 T9040 T9037 arg1Of mice,type
R6256 T9040 T9039 arg1Of mice,A20myel-KO
R6257 T9042 T9007 arg1Of and,Also
R6258 T9042 T9008 arg1Of and,","
R6259 T9042 T9041 arg1Of and,","
R626 T1357 T1358 arg1Of initiation,of
R6260 T9043 T9042 arg2Of was,and
R6261 T9045 T9043 arg2Of lower,was
R6262 T9045 T9044 arg1Of lower,slightly
R6263 T9045 T9046 arg1Of lower,in
R6264 T9048 T9046 arg2Of mice,in
R6265 T9048 T9047 arg1Of mice,A20myel-KO
R6266 T9048 T9049 arg1Of mice,(
R6267 T9050 T9049 arg2Of data,(
R6268 T9050 T9052 arg2Of data,shown
R6269 T9052 T9051 arg1Of shown,not
R627 T1357 T1365 arg1Of initiation,involves
R6270 T9053 T9049 arg3Of ),(
R6271 T9056 T9057 arg1Of we,measured
R6272 T9057 T9054 arg1Of measured,Next
R6273 T9057 T9055 arg1Of measured,","
R6274 T9057 T9061 arg1Of measured,at
R6275 T9060 T9057 arg2Of titers,measured
R6276 T9060 T9058 arg1Of titers,pulmonary
R6277 T9060 T9059 arg1Of titers,viral
R6278 T9062 T9063 arg1Of 4,","
R6279 T9063 T9065 arg1Of ",",and
R628 T1364 T1358 arg2Of response,of
R6280 T9064 T9063 arg2Of 7,","
R6281 T9066 T9065 arg2Of 10,and
R6282 T9069 T9061 arg2Of infection,at
R6283 T9069 T9062 arg1Of infection,4
R6284 T9069 T9064 arg1Of infection,7
R6285 T9069 T9066 arg1Of infection,10
R6286 T9069 T9067 arg1Of infection,days
R6287 T9069 T9068 arg1Of infection,post
R6288 T9071 T9070 arg1Of differences,No
R6289 T9071 T9072 arg1Of differences,in
R629 T1364 T1359 arg1Of response,a
R6290 T9071 T9075 arg1Of differences,were
R6291 T9071 T9076 arg2Of differences,observed
R6292 T9074 T9072 arg2Of titers,in
R6293 T9074 T9073 arg1Of titers,viral
R6294 T9076 T9075 arg2Of observed,were
R6295 T9076 T9077 arg1Of observed,in
R6296 T9076 T9080 arg1Of observed,versus
R6297 T9076 T9084 arg1Of observed,at
R6298 T9079 T9077 arg2Of mice,in
R6299 T9079 T9078 arg1Of mice,A20myel-KO
R63 T133 T131 arg2Of production,induces
R630 T1364 T1360 arg1Of response,protective
R6300 T9083 T9080 arg2Of mice,versus
R6301 T9083 T9081 arg1Of mice,wild
R6302 T9083 T9082 arg1Of mice,type
R6303 T9086 T9087 arg1Of 4,and
R6304 T9088 T9087 arg2Of 7,and
R6305 T9090 T9084 arg2Of infection,at
R6306 T9090 T9085 arg1Of infection,day
R6307 T9090 T9086 arg1Of infection,4
R6308 T9090 T9088 arg1Of infection,7
R6309 T9090 T9089 arg1Of infection,post
R631 T1364 T1361 arg1Of response,innate
R6310 T9095 T9093 arg2Of days,after
R6311 T9095 T9094 arg1Of days,10
R6312 T9099 T9097 arg1Of virus,almost
R6313 T9099 T9098 arg1Of virus,no
R6314 T9099 T9100 arg1Of virus,could
R6315 T9099 T9101 arg1Of virus,be
R6316 T9099 T9102 arg2Of virus,detected
R6317 T9102 T9091 arg1Of detected,However
R6318 T9102 T9092 arg1Of detected,","
R6319 T9102 T9093 arg1Of detected,after
R632 T1364 T1362 arg1Of response,antiviral
R6320 T9102 T9096 arg1Of detected,","
R6321 T9102 T9100 arg2Of detected,could
R6322 T9102 T9101 arg2Of detected,be
R6323 T9102 T9103 arg1Of detected,in
R6324 T9102 T9109 arg1Of detected,while
R6325 T9105 T9103 arg2Of lungs,in
R6326 T9105 T9104 arg1Of lungs,the
R6327 T9105 T9106 arg1Of lungs,of
R6328 T9108 T9106 arg2Of mice,of
R6329 T9108 T9107 arg1Of mice,A20myel-KO
R633 T1364 T1363 arg1Of response,immune
R6330 T9113 T9110 arg1Of particles,abundant
R6331 T9113 T9111 arg1Of particles,infectious
R6332 T9113 T9112 arg1Of particles,viral
R6333 T9113 T9114 arg1Of particles,could
R6334 T9113 T9116 arg1Of particles,be
R6335 T9113 T9117 arg2Of particles,isolated
R6336 T9117 T9109 arg2Of isolated,while
R6337 T9117 T9114 arg2Of isolated,could
R6338 T9117 T9115 arg1Of isolated,still
R6339 T9117 T9116 arg2Of isolated,be
R634 T1367 T1365 arg2Of action,involves
R6340 T9117 T9118 arg1Of isolated,from
R6341 T9119 T9118 arg2Of lungs,from
R6342 T9119 T9120 arg1Of lungs,of
R6343 T9124 T9120 arg2Of mice,of
R6344 T9124 T9121 arg1Of mice,all
R6345 T9124 T9122 arg1Of mice,wild
R6346 T9124 T9123 arg1Of mice,type
R6347 T9124 T9125 arg1Of mice,(
R6348 T9127 T9125 arg2Of 3B,(
R6349 T9127 T9126 arg1Of 3B,figure
R635 T1367 T1366 arg1Of action,the
R6350 T9128 T9125 arg3Of ),(
R6351 T9129 T9130 arg1Of This,indicates
R6352 T9132 T9133 arg1Of loss,of
R6353 T9132 T9135 arg1Of loss,in
R6354 T9132 T9138 arg1Of loss,does
R6355 T9132 T9140 arg1Of loss,affect
R6356 T9132 T9145 arg1Of loss,contributes
R6357 T9134 T9133 arg2Of A20,of
R6358 T9137 T9135 arg2Of cells,in
R6359 T9137 T9136 arg1Of cells,myeloid
R636 T1367 T1368 arg1Of action,of
R6360 T9140 T9138 arg2Of affect,does
R6361 T9140 T9139 arg1Of affect,not
R6362 T9140 T9144 arg1Of affect,but
R6363 T9143 T9140 arg2Of replication,affect
R6364 T9143 T9141 arg1Of replication,early
R6365 T9143 T9142 arg1Of replication,viral
R6366 T9144 T9130 arg2Of but,indicates
R6367 T9144 T9131 arg1Of but,that
R6368 T9145 T9144 arg2Of contributes,but
R6369 T9145 T9146 arg1Of contributes,to
R637 T1372 T1368 arg2Of receptors,of
R6370 T9145 T9149 arg1Of contributes,at
R6371 T9145 T9152 arg1Of contributes,during
R6372 T9148 T9146 arg2Of clearance,to
R6373 T9148 T9147 arg1Of clearance,viral
R6374 T9151 T9149 arg2Of stages,at
R6375 T9151 T9150 arg1Of stages,later
R6376 T9153 T9152 arg2Of infection,during
R6377 T9155 T9154 arg1Of verify,To
R6378 T9155 T9156 arg1Of verify,if
R6379 T9158 T9157 arg1Of deficiency,A20
R638 T1372 T1369 arg2Of receptors,specialized
R6380 T9158 T9159 arg1Of deficiency,in
R6381 T9158 T9162 arg1Of deficiency,affects
R6382 T9161 T9159 arg2Of cells,in
R6383 T9161 T9160 arg1Of cells,myeloid
R6384 T9162 T9156 arg2Of affects,if
R6385 T9165 T9162 arg2Of expression,affects
R6386 T9165 T9163 arg1Of expression,IAV-induced
R6387 T9165 T9164 arg1Of expression,gene
R6388 T9165 T9166 arg1Of expression,in
R6389 T9168 T9166 arg2Of lung,in
R639 T1372 T1370 arg1Of receptors,pattern
R6390 T9168 T9167 arg1Of lung,the
R6391 T9170 T9155 arg1Of we,verify
R6392 T9170 T9171 arg1Of we,analyzed
R6393 T9171 T9154 modOf analyzed,To
R6394 T9171 T9169 arg1Of analyzed,","
R6395 T9171 T9179 arg1Of analyzed,in
R6396 T9173 T9171 arg2Of levels,analyzed
R6397 T9173 T9172 arg1Of levels,the
R6398 T9173 T9174 arg1Of levels,of
R6399 T9176 T9175 arg1Of chemokines,several
R64 T133 T132 arg1Of production,the
R640 T1372 T1371 arg1Of receptors,recognition
R6400 T9176 T9177 arg1Of chemokines,and
R6401 T9177 T9174 arg2Of and,of
R6402 T9178 T9177 arg2Of cytokines,and
R6403 T9182 T9179 arg2Of lavage,in
R6404 T9182 T9180 arg1Of lavage,the
R6405 T9182 T9181 arg1Of lavage,bronchoalveolar
R6406 T9182 T9183 arg1Of lavage,(
R6407 T9182 T9186 arg1Of lavage,at
R6408 T9184 T9183 arg2Of BAL,(
R6409 T9185 T9183 arg3Of ),(
R641 T1372 T1373 arg1Of receptors,(
R6410 T9188 T9189 arg1Of 4,","
R6411 T9189 T9191 arg1Of ",",and
R6412 T9190 T9189 arg2Of 7,","
R6413 T9192 T9191 arg2Of day,and
R6414 T9192 T9193 arg1Of day,10
R6415 T9195 T9186 arg2Of infection,at
R6416 T9195 T9187 arg1Of infection,day
R6417 T9195 T9188 arg1Of infection,4
R6418 T9195 T9190 arg1Of infection,7
R6419 T9195 T9192 arg1Of infection,day
R642 T1372 T1376 arg1Of receptors,","
R6420 T9195 T9194 arg1Of infection,following
R6421 T9196 T9197 arg1Of Levels,of
R6422 T9196 T9207 arg1Of Levels,were
R6423 T9196 T9209 arg1Of Levels,higher
R6424 T9198 T9199 arg1Of KC,and
R6425 T9199 T9205 arg1Of and,as
R6426 T9201 T9199 arg2Of chemokines,and
R6427 T9201 T9200 arg1Of chemokines,MIP-2
R6428 T9205 T9197 arg2Of as,of
R6429 T9205 T9202 arg1Of as,","
R643 T1372 T1377 arg1Of receptors,which
R6430 T9205 T9203 arg1Of as,as
R6431 T9205 T9204 arg1Of as,well
R6432 T9206 T9205 arg2Of IL-6,as
R6433 T9207 T9210 arg1Of were,at
R6434 T9207 T9214 arg1Of were,in
R6435 T9207 T9221 arg1Of were,compared
R6436 T9209 T9207 arg2Of higher,were
R6437 T9209 T9208 arg1Of higher,significantly
R6438 T9213 T9210 arg2Of p.i.,at
R6439 T9213 T9211 arg1Of p.i.,day
R644 T1372 T1378 arg1Of receptors,detect
R6440 T9213 T9212 arg1Of p.i.,7
R6441 T9215 T9214 arg2Of BAL,in
R6442 T9215 T9216 arg1Of BAL,from
R6443 T9220 T9216 arg2Of mice,from
R6444 T9220 T9217 arg1Of mice,IAV
R6445 T9220 T9218 arg1Of mice,infected
R6446 T9220 T9219 arg1Of mice,A20myel-KO
R6447 T9222 T9221 arg2Of to,compared
R6448 T9227 T9222 arg2Of mice,to
R6449 T9227 T9223 arg1Of mice,IAV
R645 T1374 T1373 arg2Of PRR,(
R6450 T9227 T9224 arg1Of mice,infected
R6451 T9227 T9225 arg1Of mice,wild
R6452 T9227 T9226 arg1Of mice,type
R6453 T9227 T9228 arg1Of mice,(
R6454 T9230 T9228 arg2Of 3C,(
R6455 T9230 T9229 arg1Of 3C,figure
R6456 T9231 T9228 arg3Of ),(
R6457 T9234 T9232 arg2Of observations,Unlike
R6458 T9234 T9233 arg1Of observations,our
R6459 T9234 T9235 arg1Of observations,with
R646 T1375 T1373 arg3Of ),(
R6460 T9240 T9235 arg2Of macrophages,with
R6461 T9240 T9236 arg1Of macrophages,in
R6462 T9240 T9237 arg1Of macrophages,vitro
R6463 T9240 T9238 arg2Of macrophages,stimulated
R6464 T9240 T9239 arg1Of macrophages,primary
R6465 T9241 T9242 arg1Of we,could
R6466 T9241 T9244 arg1Of we,detect
R6467 T9244 T9232 arg1Of detect,Unlike
R6468 T9244 T9242 arg2Of detect,could
R6469 T9244 T9243 arg1Of detect,not
R647 T1381 T1378 arg2Of structures,detect
R6470 T9247 T9244 arg2Of increase,detect
R6471 T9247 T9245 arg1Of increase,a
R6472 T9247 T9246 arg1Of increase,significant
R6473 T9247 T9248 arg1Of increase,in
R6474 T9247 T9253 arg1Of increase,in
R6475 T9249 T9250 arg1Of MCP-1,or
R6476 T9251 T9250 arg2Of IFNα,or
R6477 T9252 T9248 arg2Of production,in
R6478 T9252 T9249 arg1Of production,MCP-1
R6479 T9252 T9251 arg1Of production,IFNα
R648 T1381 T1379 arg2Of structures,conserved
R6480 T9255 T9253 arg2Of lungs,in
R6481 T9255 T9254 arg1Of lungs,the
R6482 T9255 T9256 arg1Of lungs,of
R6483 T9258 T9256 arg2Of animals,of
R6484 T9258 T9257 arg1Of animals,A20myel-KO
R6485 T9258 T9259 arg1Of animals,(
R6486 T9261 T9259 arg2Of 3C,(
R6487 T9261 T9260 arg1Of 3C,figure
R6488 T9262 T9259 arg3Of ),(
R6489 T9263 T9264 arg1Of KC,is
R649 T1381 T1380 arg1Of structures,molecular
R6490 T9263 T9271 arg1Of KC,serves
R6491 T9264 T9270 arg1Of is,and
R6492 T9267 T9264 arg2Of orthologue,is
R6493 T9267 T9265 arg1Of orthologue,the
R6494 T9267 T9266 arg1Of orthologue,murine
R6495 T9267 T9268 arg1Of orthologue,of
R6496 T9269 T9268 arg2Of IL-8,of
R6497 T9270 T9280 arg1Of and,","
R6498 T9270 T9281 arg1Of and,while
R6499 T9271 T9270 arg2Of serves,and
R65 T133 T134 arg1Of production,of
R650 T1381 T1382 arg1Of structures,of
R6500 T9271 T9272 arg1Of serves,together
R6501 T9271 T9273 arg1Of serves,with
R6502 T9271 T9275 arg1Of serves,as
R6503 T9274 T9273 arg2Of MIP-2,with
R6504 T9277 T9275 arg2Of chemoattractant,as
R6505 T9277 T9276 arg1Of chemoattractant,a
R6506 T9277 T9278 arg1Of chemoattractant,for
R6507 T9279 T9278 arg2Of neutrophils,for
R6508 T9282 T9283 arg1Of MCP-1,is
R6509 T9282 T9285 arg2Of MCP-1,known
R651 T1385 T1382 arg2Of pathogen,of
R6510 T9285 T9281 arg2Of known,while
R6511 T9285 T9283 arg2Of known,is
R6512 T9285 T9284 arg1Of known,mainly
R6513 T9285 T9286 arg1Of known,as
R6514 T9288 T9286 arg2Of chemoattractant,as
R6515 T9288 T9287 arg1Of chemoattractant,a
R6516 T9288 T9289 arg1Of chemoattractant,for
R6517 T9290 T9289 arg2Of monocytes,for
R6518 T9290 T9291 arg1Of monocytes,","
R6519 T9290 T9292 arg1Of monocytes,which
R652 T1385 T1383 arg1Of pathogen,the
R6520 T9290 T9294 arg1Of monocytes,develop
R6521 T9290 T9298 arg1Of monocytes,entering
R6522 T9294 T9293 arg1Of develop,eventually
R6523 T9294 T9295 arg1Of develop,into
R6524 T9294 T9297 arg1Of develop,upon
R6525 T9296 T9295 arg2Of macrophages,into
R6526 T9298 T9297 arg2Of entering,upon
R6527 T9298 T9302 arg1Of entering,[
R6528 T9301 T9298 arg2Of lumen,entering
R6529 T9301 T9299 arg1Of lumen,the
R653 T1385 T1384 arg1Of pathogen,invading
R6530 T9301 T9300 arg1Of lumen,alveolar
R6531 T9303 T9302 arg2Of 60,[
R6532 T9304 T9302 arg3Of ],[
R6533 T9305 T9306 arg1Of Consistent,with
R6534 T9309 T9310 arg1Of KC,and
R6535 T9311 T9310 arg2Of MIP-2,and
R6536 T9312 T9306 arg2Of levels,with
R6537 T9312 T9307 arg1Of levels,the
R6538 T9312 T9308 arg1Of levels,higher
R6539 T9312 T9309 arg1Of levels,KC
R654 T1386 T1387 arg1Of Triggering,of
R6540 T9312 T9311 arg1Of levels,MIP-2
R6541 T9312 T9313 arg1Of levels,in
R6542 T9315 T9313 arg2Of mice,in
R6543 T9315 T9314 arg1Of mice,A20myel-KO
R6544 T9318 T9317 arg1Of number,the
R6545 T9318 T9319 arg1Of number,of
R6546 T9318 T9337 arg1Of number,was
R6547 T9318 T9339 arg1Of number,higher
R6548 T9320 T9319 arg2Of neutrophils,of
R6549 T9320 T9321 arg1Of neutrophils,(
R655 T1386 T1389 arg1Of Triggering,induces
R6550 T9320 T9327 arg1Of neutrophils,that
R6551 T9320 T9328 arg1Of neutrophils,were
R6552 T9320 T9329 arg2Of neutrophils,recruited
R6553 T9325 T9321 arg2Of F4/80−,(
R6554 T9325 T9322 arg1Of F4/80−,CD11b+
R6555 T9325 T9323 arg1Of F4/80−,Ly6C+
R6556 T9325 T9324 arg1Of F4/80−,Ly6G+
R6557 T9326 T9321 arg3Of ),(
R6558 T9329 T9328 arg2Of recruited,were
R6559 T9329 T9330 arg1Of recruited,in
R656 T1388 T1387 arg2Of PRRs,of
R6560 T9333 T9330 arg2Of spaces,in
R6561 T9333 T9331 arg1Of spaces,the
R6562 T9333 T9332 arg1Of spaces,bronchoalveolar
R6563 T9333 T9334 arg1Of spaces,upon
R6564 T9336 T9334 arg2Of infection,upon
R6565 T9336 T9335 arg1Of infection,IAV
R6566 T9337 T9305 arg1Of was,Consistent
R6567 T9337 T9316 arg1Of was,","
R6568 T9337 T9340 arg1Of was,throughout
R6569 T9337 T9342 arg1Of was,in
R657 T1389 T1416 arg1Of induces,through
R6570 T9337 T9345 arg1Of was,compared
R6571 T9339 T9337 arg2Of higher,was
R6572 T9339 T9338 arg1Of higher,clearly
R6573 T9341 T9340 arg2Of infection,throughout
R6574 T9344 T9342 arg2Of mice,in
R6575 T9344 T9343 arg1Of mice,A20myel-KO
R6576 T9346 T9345 arg2Of to,compared
R6577 T9348 T9346 arg2Of animals,to
R6578 T9348 T9347 arg1Of animals,control
R6579 T9348 T9349 arg1Of animals,(
R658 T1391 T1389 arg2Of production,induces
R6580 T9351 T9349 arg2Of 3D,(
R6581 T9351 T9350 arg1Of 3D,figure
R6582 T9352 T9349 arg3Of ),(
R6583 T9354 T9355 arg1Of we,could
R6584 T9354 T9356 arg1Of we,detect
R6585 T9356 T9353 arg2Of detect,Although
R6586 T9356 T9355 arg2Of detect,could
R6587 T9359 T9356 arg2Of increase,detect
R6588 T9359 T9357 arg1Of increase,a
R6589 T9359 T9358 arg1Of increase,significant
R659 T1391 T1390 arg1Of production,the
R6590 T9359 T9360 arg1Of increase,in
R6591 T9361 T9362 arg1Of monocyte,(
R6592 T9364 T9362 arg2Of Ly6C+,(
R6593 T9364 T9363 arg1Of Ly6C+,CD11b+
R6594 T9365 T9362 arg3Of ),(
R6595 T9366 T9360 arg2Of recruitment,in
R6596 T9366 T9361 arg1Of recruitment,monocyte
R6597 T9366 T9367 arg1Of recruitment,at
R6598 T9371 T9367 arg2Of infection,at
R6599 T9371 T9368 arg1Of infection,day
R66 T136 T135 arg1Of cytokines,proinflammatory
R660 T1391 T1392 arg1Of production,of
R6600 T9371 T9369 arg1Of infection,4
R6601 T9371 T9370 arg1Of infection,post
R6602 T9373 T9374 arg1Of this,was
R6603 T9373 T9376 arg1Of this,evident
R6604 T9374 T9353 arg1Of was,Although
R6605 T9374 T9372 arg1Of was,","
R6606 T9374 T9375 arg1Of was,not
R6607 T9374 T9377 arg1Of was,at
R6608 T9374 T9381 arg1Of was,after
R6609 T9376 T9374 arg2Of evident,was
R661 T1395 T1393 arg1Of cytokines,host
R6610 T9380 T9377 arg2Of points,at
R6611 T9380 T9378 arg1Of points,later
R6612 T9380 T9379 arg1Of points,time
R6613 T9382 T9381 arg2Of infection,after
R6614 T9382 T9383 arg1Of infection,(
R6615 T9382 T9387 arg1Of infection,","
R6616 T9382 T9388 arg1Of infection,which
R6617 T9382 T9389 arg1Of infection,is
R6618 T9382 T9390 arg1Of infection,consistent
R6619 T9385 T9383 arg2Of 3D,(
R662 T1395 T1394 arg1Of cytokines,proinflammatory
R6620 T9385 T9384 arg1Of 3D,figure
R6621 T9386 T9383 arg3Of ),(
R6622 T9390 T9389 arg2Of consistent,is
R6623 T9390 T9391 arg1Of consistent,with
R6624 T9390 T9397 arg1Of consistent,in
R6625 T9394 T9391 arg2Of expression,with
R6626 T9394 T9392 arg1Of expression,the
R6627 T9394 T9393 arg1Of expression,equal
R6628 T9394 T9395 arg1Of expression,of
R6629 T9396 T9395 arg2Of MCP-1,of
R663 T1395 T1396 arg1Of cytokines,(
R6630 T9399 T9397 arg2Of groups,in
R6631 T9399 T9398 arg1Of groups,both
R6632 T9399 T9400 arg1Of groups,of
R6633 T9401 T9400 arg2Of mice,of
R6634 T9403 T9402 arg1Of number,The
R6635 T9403 T9404 arg1Of number,of
R6636 T9403 T9414 arg1Of number,was
R6637 T9403 T9416 arg2Of number,elevated
R6638 T9403 T9421 arg1Of number,did
R6639 T9403 T9423 arg1Of number,differ
R664 T1395 T1404 arg1Of cytokines,and
R6640 T9407 T9404 arg2Of macrophages,of
R6641 T9407 T9405 arg1Of macrophages,resident
R6642 T9407 T9406 arg1Of macrophages,alveolar
R6643 T9407 T9408 arg1Of macrophages,(
R6644 T9412 T9408 arg2Of CD11b−,(
R6645 T9412 T9409 arg1Of CD11b−,autofluorescent+
R6646 T9412 T9410 arg1Of CD11b−,CD11c+
R6647 T9412 T9411 arg1Of CD11b−,F4/80+
R6648 T9413 T9408 arg3Of ),(
R6649 T9416 T9414 arg2Of elevated,was
R665 T1398 T1399 arg1Of TNF,","
R6650 T9416 T9415 arg1Of elevated,also
R6651 T9416 T9417 arg1Of elevated,in
R6652 T9416 T9420 arg1Of elevated,but
R6653 T9419 T9417 arg2Of mice,in
R6654 T9419 T9418 arg1Of mice,A20myel-KO
R6655 T9423 T9420 arg2Of differ,but
R6656 T9423 T9421 arg2Of differ,did
R6657 T9423 T9422 arg1Of differ,not
R6658 T9423 T9424 arg1Of differ,significantly
R6659 T9423 T9425 arg1Of differ,between
R666 T1399 T1401 arg1Of ",",and
R6660 T9427 T9428 arg1Of infected,or
R6661 T9429 T9428 arg2Of mock,or
R6662 T9431 T9425 arg2Of mice,between
R6663 T9431 T9426 arg1Of mice,IAV
R6664 T9431 T9427 arg1Of mice,infected
R6665 T9431 T9429 arg1Of mice,mock
R6666 T9431 T9430 arg1Of mice,infected
R6667 T9431 T9432 arg1Of mice,(
R6668 T9434 T9432 arg2Of 3D,(
R6669 T9434 T9433 arg1Of 3D,figure
R667 T1400 T1399 arg2Of IL-6,","
R6670 T9435 T9432 arg3Of ),(
R6671 T9436 T9437 arg1Of Elimination,of
R6672 T9436 T9441 arg1Of Elimination,depends
R6673 T9440 T9437 arg2Of cells,of
R6674 T9440 T9438 arg1Of cells,IAV
R6675 T9440 T9439 arg1Of cells,infected
R6676 T9441 T9442 arg1Of depends,on
R6677 T9445 T9442 arg2Of expansion,on
R6678 T9445 T9443 arg1Of expansion,the
R6679 T9445 T9444 arg1Of expansion,clonal
R668 T1401 T1396 arg2Of and,(
R6680 T9445 T9446 arg1Of expansion,of
R6681 T9452 T9446 arg2Of cells,of
R6682 T9452 T9447 arg1Of cells,virus
R6683 T9452 T9448 arg1Of cells,specific
R6684 T9452 T9449 arg1Of cells,cytotoxic
R6685 T9452 T9450 arg1Of cells,CD8+
R6686 T9452 T9451 arg1Of cells,T
R6687 T9452 T9453 arg1Of cells,(
R6688 T9452 T9456 arg1Of cells,[
R6689 T9452 T9459 arg1Of cells,","
R669 T1401 T1397 arg1Of and,e.g.
R6690 T9452 T9460 arg1Of cells,[
R6691 T9452 T9463 arg1Of cells,","
R6692 T9452 T9464 arg1Of cells,[
R6693 T9454 T9453 arg2Of CTL,(
R6694 T9455 T9453 arg3Of ),(
R6695 T9457 T9456 arg2Of 61,[
R6696 T9458 T9456 arg3Of ],[
R6697 T9461 T9460 arg2Of 62,[
R6698 T9462 T9460 arg3Of ],[
R6699 T9465 T9464 arg2Of 63,[
R67 T136 T137 arg1Of cytokines,and
R670 T1402 T1401 arg2Of IL-1,and
R6700 T9466 T9464 arg3Of ],[
R6701 T9468 T9467 arg1Of test,To
R6702 T9471 T9470 arg1Of expression,A20
R6703 T9471 T9472 arg1Of expression,in
R6704 T9471 T9475 arg1Of expression,regulates
R6705 T9474 T9472 arg2Of cells,in
R6706 T9474 T9473 arg1Of cells,myeloid
R6707 T9475 T9468 arg2Of regulates,test
R6708 T9475 T9469 arg1Of regulates,whether
R6709 T9479 T9475 arg2Of response,regulates
R671 T1403 T1396 arg3Of ),(
R6710 T9479 T9476 arg1Of response,the
R6711 T9479 T9477 arg1Of response,antiviral
R6712 T9479 T9478 arg1Of response,CTL
R6713 T9484 T9481 arg1Of cells,total
R6714 T9484 T9482 arg1Of cells,CD8+
R6715 T9484 T9483 arg1Of cells,T
R6716 T9484 T9485 arg1Of cells,and
R6717 T9485 T9468 arg1Of and,test
R6718 T9485 T9499 arg1Of and,were
R6719 T9485 T9500 arg2Of and,measured
R672 T1404 T1392 arg2Of and,of
R6720 T9489 T9486 arg1Of B,virus
R6721 T9489 T9487 arg1Of B,specific
R6722 T9489 T9488 arg1Of B,Granzyme
R6723 T9489 T9490 arg1Of B,(
R6724 T9489 T9493 arg1Of B,and
R6725 T9491 T9490 arg2Of GrB,(
R6726 T9492 T9490 arg3Of ),(
R6727 T9493 T9485 arg2Of and,and
R6728 T9494 T9493 arg2Of IFNγ,and
R6729 T9494 T9495 arg1Of IFNγ,expressing
R673 T1407 T1404 arg2Of interferons,and
R6730 T9498 T9495 arg2Of cells,expressing
R6731 T9498 T9496 arg1Of cells,CD8+
R6732 T9498 T9497 arg1Of cells,T
R6733 T9500 T9467 modOf measured,To
R6734 T9500 T9480 arg1Of measured,","
R6735 T9500 T9499 arg2Of measured,were
R6736 T9500 T9501 arg1Of measured,in
R6737 T9502 T9503 arg1Of BAL,and
R6738 T9504 T9503 arg2Of lung,and
R6739 T9505 T9501 arg2Of parenchyma,in
R674 T1407 T1405 arg1Of interferons,type
R6740 T9505 T9502 arg1Of parenchyma,BAL
R6741 T9505 T9504 arg1Of parenchyma,lung
R6742 T9505 T9506 arg1Of parenchyma,of
R6743 T9508 T9509 arg1Of type,and
R6744 T9510 T9509 arg2Of A20myel-KO,and
R6745 T9511 T9506 arg2Of mice,of
R6746 T9511 T9507 arg1Of mice,wild
R6747 T9511 T9508 arg1Of mice,type
R6748 T9511 T9510 arg1Of mice,A20myel-KO
R6749 T9514 T9512 arg1Of increase,A
R675 T1407 T1406 arg1Of interferons,I
R6750 T9514 T9513 arg1Of increase,clear
R6751 T9514 T9515 arg1Of increase,in
R6752 T9514 T9519 arg1Of increase,could
R6753 T9514 T9520 arg1Of increase,be
R6754 T9514 T9521 arg2Of increase,detected
R6755 T9518 T9515 arg2Of cells,in
R6756 T9518 T9516 arg1Of cells,CD8+
R6757 T9518 T9517 arg1Of cells,T
R6758 T9521 T9519 arg2Of detected,could
R6759 T9521 T9520 arg2Of detected,be
R676 T1407 T1408 arg1Of interferons,(
R6760 T9521 T9522 arg1Of detected,at
R6761 T9521 T9530 arg1Of detected,but
R6762 T9524 T9525 arg1Of 7,and
R6763 T9526 T9525 arg2Of 10,and
R6764 T9528 T9522 arg2Of infection,at
R6765 T9528 T9523 arg1Of infection,day
R6766 T9528 T9524 arg1Of infection,7
R6767 T9528 T9526 arg1Of infection,10
R6768 T9528 T9527 arg1Of infection,post
R6769 T9530 T9529 arg1Of but,","
R677 T1409 T1410 arg1Of interferon-α,(
R6770 T9532 T9531 arg1Of differences,no
R6771 T9532 T9533 arg1Of differences,were
R6772 T9532 T9534 arg2Of differences,observed
R6773 T9534 T9530 arg2Of observed,but
R6774 T9534 T9533 arg2Of observed,were
R6775 T9534 T9535 arg1Of observed,between
R6776 T9536 T9537 arg1Of A20myel-KO,and
R6777 T9537 T9535 arg2Of and,between
R6778 T9540 T9537 arg2Of mice,and
R6779 T9540 T9538 arg1Of mice,wild
R678 T1409 T1413 arg1Of interferon-α,and
R6780 T9540 T9539 arg1Of mice,type
R6781 T9540 T9541 arg1Of mice,(
R6782 T9543 T9542 arg1Of S2A,figure
R6783 T9543 T9544 arg1Of S2A,and
R6784 T9544 T9541 arg2Of and,(
R6785 T9546 T9544 arg2Of S2C,and
R6786 T9546 T9545 arg1Of S2C,figure
R6787 T9547 T9541 arg3Of ),(
R6788 T9551 T9550 arg1Of number,the
R6789 T9551 T9552 arg1Of number,of
R679 T1411 T1410 arg2Of IFN-α,(
R6790 T9551 T9568 arg1Of number,were
R6791 T9551 T9570 arg2Of number,altered
R6792 T9553 T9554 arg1Of GrB,and
R6793 T9555 T9554 arg2Of IFNγ,and
R6794 T9558 T9553 arg1Of cells,GrB
R6795 T9558 T9555 arg1Of cells,IFNγ
R6796 T9558 T9556 arg1Of cells,CD8+
R6797 T9558 T9557 arg1Of cells,T
R6798 T9558 T9561 arg1Of cells,as
R6799 T9561 T9552 arg2Of as,of
R68 T137 T134 arg2Of and,of
R680 T1412 T1410 arg3Of ),(
R6800 T9561 T9559 arg1Of as,as
R6801 T9561 T9560 arg1Of as,well
R6802 T9564 T9561 arg2Of levels,as
R6803 T9564 T9562 arg1Of levels,IFNγ
R6804 T9564 T9563 arg1Of levels,expression
R6805 T9564 T9565 arg1Of levels,in
R6806 T9567 T9565 arg2Of lungs,in
R6807 T9567 T9566 arg1Of lungs,the
R6808 T9570 T9548 arg1Of altered,Also
R6809 T9570 T9549 arg1Of altered,","
R681 T1413 T1408 arg2Of and,(
R6810 T9570 T9568 arg2Of altered,were
R6811 T9570 T9569 arg1Of altered,not
R6812 T9573 T9570 arg1Of absence,altered
R6813 T9573 T9571 arg2Of absence,by
R6814 T9573 T9572 arg1Of absence,the
R6815 T9573 T9574 arg1Of absence,of
R6816 T9573 T9576 arg1Of absence,in
R6817 T9575 T9574 arg2Of A20,of
R6818 T9578 T9576 arg2Of cells,in
R6819 T9578 T9577 arg1Of cells,myeloid
R682 T1414 T1413 arg2Of IFN-β,and
R6820 T9578 T9579 arg1Of cells,(
R6821 T9581 T9579 arg2Of S2A–C,(
R6822 T9581 T9580 arg1Of S2A–C,figure
R6823 T9582 T9579 arg3Of ),(
R6824 T9583 T9584 arg1Of Protection,against
R6825 T9583 T9587 arg1Of Protection,is
R6826 T9583 T9589 arg2Of Protection,provided
R6827 T9586 T9584 arg2Of infection,against
R6828 T9586 T9585 arg1Of infection,IAV
R6829 T9589 T9587 arg2Of provided,is
R683 T1415 T1408 arg3Of ),(
R6830 T9589 T9588 arg1Of provided,also
R6831 T9594 T9589 arg1Of response,provided
R6832 T9594 T9590 arg2Of response,by
R6833 T9594 T9591 arg1Of response,the
R6834 T9594 T9592 arg1Of response,humoral
R6835 T9594 T9593 arg1Of response,immune
R6836 T9596 T9595 arg1Of test,To
R6837 T9598 T9599 arg1Of loss,of
R6838 T9598 T9601 arg1Of loss,in
R6839 T9598 T9604 arg1Of loss,affects
R684 T1417 T1416 arg2Of activation,through
R6840 T9600 T9599 arg2Of A20,of
R6841 T9603 T9601 arg2Of cells,in
R6842 T9603 T9602 arg1Of cells,myeloid
R6843 T9604 T9596 arg2Of affects,test
R6844 T9604 T9597 arg1Of affects,whether
R6845 T9608 T9604 arg2Of immunity,affects
R6846 T9608 T9605 arg1Of immunity,B
R6847 T9608 T9606 arg1Of immunity,cell
R6848 T9608 T9607 arg2Of immunity,mediated
R6849 T9610 T9596 arg1Of we,test
R685 T1417 T1418 arg1Of activation,of
R6850 T9610 T9611 arg1Of we,determined
R6851 T9611 T9595 modOf determined,To
R6852 T9611 T9609 arg1Of determined,","
R6853 T9611 T9618 arg1Of determined,in
R6854 T9614 T9613 arg2Of HA,(
R6855 T9615 T9613 arg3Of ),(
R6856 T9617 T9611 arg2Of titers,determined
R6857 T9617 T9612 arg1Of titers,hemagglutinin
R6858 T9617 T9613 arg1Of titers,(
R6859 T9617 T9616 arg1Of titers,antibody
R686 T1421 T1418 arg2Of pathways,of
R6860 T9620 T9618 arg2Of serum,in
R6861 T9620 T9619 arg1Of serum,the
R6862 T9620 T9621 arg1Of serum,of
R6863 T9622 T9623 arg1Of A20myel-KO,and
R6864 T9624 T9623 arg2Of wild,and
R6865 T9626 T9621 arg2Of littermates,of
R6866 T9626 T9622 arg1Of littermates,A20myel-KO
R6867 T9626 T9624 arg1Of littermates,wild
R6868 T9626 T9625 arg1Of littermates,type
R6869 T9630 T9629 arg1Of differences,no
R687 T1421 T1419 arg1Of pathways,downstream
R6870 T9630 T9631 arg1Of differences,could
R6871 T9630 T9632 arg1Of differences,be
R6872 T9630 T9633 arg2Of differences,detected
R6873 T9633 T9627 arg1Of detected,However
R6874 T9633 T9628 arg1Of detected,","
R6875 T9633 T9631 arg2Of detected,could
R6876 T9633 T9632 arg2Of detected,be
R6877 T9633 T9634 arg1Of detected,between
R6878 T9633 T9644 arg1Of detected,","
R6879 T9633 T9645 modOf detected,indicating
R688 T1421 T1420 arg1Of pathways,signaling
R6880 T9636 T9635 arg1Of type,wild
R6881 T9636 T9637 arg1Of type,and
R6882 T9637 T9634 arg2Of and,between
R6883 T9639 T9637 arg2Of animals,and
R6884 T9639 T9638 arg1Of animals,A20myel-KO
R6885 T9639 T9640 arg1Of animals,(
R6886 T9642 T9640 arg2Of S2D,(
R6887 T9642 T9641 arg1Of S2D,figure
R6888 T9643 T9640 arg3Of ),(
R6889 T9648 T9647 arg1Of immunity,humoral
R689 T1421 T1422 arg1Of pathways,that
R6890 T9648 T9649 arg1Of immunity,is
R6891 T9648 T9651 arg2Of immunity,affected
R6892 T9651 T9645 arg2Of affected,indicating
R6893 T9651 T9646 arg1Of affected,that
R6894 T9651 T9649 arg2Of affected,is
R6895 T9651 T9650 arg1Of affected,not
R6896 T9654 T9651 arg1Of expression,affected
R6897 T9654 T9652 arg2Of expression,by
R6898 T9654 T9653 arg1Of expression,A20
R6899 T9654 T9655 arg1Of expression,in
R69 T139 T137 arg2Of interferon,and
R690 T1421 T1423 arg1Of pathways,control
R6900 T9657 T9655 arg2Of cells,in
R6901 T9657 T9656 arg1Of cells,myeloid
R6902 T9661 T9660 arg1Of data,these
R6903 T9661 T9662 arg1Of data,suggest
R6904 T9662 T9658 arg1Of suggest,Together
R6905 T9662 T9659 arg1Of suggest,","
R6906 T9664 T9665 arg1Of mechanisms,other
R6907 T9664 T9669 arg1Of mechanisms,","
R6908 T9664 T9671 arg1Of mechanisms,as
R6909 T9664 T9692 arg1Of mechanisms,contribute
R691 T1423 T1439 arg1Of control,","
R6910 T9665 T9666 arg1Of other,than
R6911 T9668 T9666 arg2Of immunity,than
R6912 T9668 T9667 arg1Of immunity,adaptive
R6913 T9671 T9670 arg1Of as,such
R6914 T9676 T9671 arg2Of response,as
R6915 T9676 T9672 arg1Of response,an
R6916 T9676 T9673 arg2Of response,increased
R6917 T9676 T9674 arg1Of response,innate
R6918 T9676 T9675 arg1Of response,immune
R6919 T9676 T9677 arg1Of response,","
R692 T1423 T1440 arg1Of control,[
R6920 T9676 T9678 arg2Of response,characterized
R6921 T9682 T9678 arg1Of influx,characterized
R6922 T9682 T9679 arg2Of influx,by
R6923 T9682 T9680 arg1Of influx,an
R6924 T9682 T9681 arg2Of influx,increased
R6925 T9682 T9683 arg1Of influx,of
R6926 T9682 T9688 arg1Of influx,of
R6927 T9684 T9685 arg1Of neutrophils,and
R6928 T9685 T9683 arg2Of and,of
R6929 T9687 T9685 arg2Of numbers,and
R693 T1426 T1423 arg2Of factors,control
R6930 T9687 T9686 arg2Of numbers,increased
R6931 T9690 T9688 arg2Of macrophages,of
R6932 T9690 T9689 arg1Of macrophages,alveolar
R6933 T9692 T9662 arg2Of contribute,suggest
R6934 T9692 T9663 arg1Of contribute,that
R6935 T9692 T9691 arg1Of contribute,","
R6936 T9692 T9693 arg1Of contribute,to
R6937 T9697 T9693 arg2Of clearance,to
R6938 T9697 T9694 arg1Of clearance,the
R6939 T9697 T9695 arg1Of clearance,better
R694 T1426 T1424 arg1Of factors,various
R6940 T9697 T9696 arg1Of clearance,viral
R6941 T9697 T9698 arg1Of clearance,in
R6942 T9700 T9698 arg2Of mice,in
R6943 T9700 T9699 arg1Of mice,A20myel-KO
R6944 T9701 T9702 arg1Of It,is
R6945 T9701 T9704 arg2Of It,believed
R6946 T9704 T9702 arg2Of believed,is
R6947 T9704 T9703 arg1Of believed,generally
R6948 T9707 T9706 arg1Of mortality,IAV-induced
R6949 T9707 T9708 arg1Of mortality,is
R695 T1426 T1425 arg1Of factors,transcription
R6950 T9707 T9710 arg1Of mortality,to
R6951 T9708 T9704 arg3Of is,believed
R6952 T9708 T9705 arg1Of is,that
R6953 T9710 T9708 arg2Of to,is
R6954 T9710 T9709 arg1Of to,due
R6955 T9714 T9710 arg2Of response,to
R6956 T9714 T9711 arg1Of response,an
R6957 T9714 T9712 arg1Of response,excessive
R6958 T9714 T9713 arg1Of response,proinflammatory
R6959 T9714 T9715 arg1Of response,in
R696 T1426 T1428 arg1Of factors,as
R6960 T9717 T9715 arg2Of lung,in
R6961 T9717 T9716 arg1Of lung,the
R6962 T9718 T9720 arg1Of We,analyzed
R6963 T9720 T9719 arg1Of analyzed,therefore
R6964 T9726 T9723 arg2Of production,increased
R6965 T9726 T9724 arg1Of production,proinflammatory
R6966 T9726 T9725 arg1Of production,cytokine
R6967 T9726 T9727 arg1Of production,and
R6968 T9727 T9722 arg1Of and,the
R6969 T9727 T9732 arg1Of and,in
R697 T1428 T1427 arg1Of as,such
R6970 T9727 T9735 arg1Of and,affects
R6971 T9728 T9727 arg2Of infiltration,and
R6972 T9728 T9729 arg1Of infiltration,of
R6973 T9731 T9729 arg2Of cells,of
R6974 T9731 T9730 arg1Of cells,proinflammatory
R6975 T9734 T9732 arg2Of mice,in
R6976 T9734 T9733 arg1Of mice,A20myel-KO
R6977 T9735 T9720 arg2Of affects,analyzed
R6978 T9735 T9721 arg1Of affects,whether
R6979 T9736 T9735 arg2Of mortality,affects
R698 T1429 T1430 arg1Of NF-κB,","
R6980 T9736 T9737 arg2Of mortality,induced
R6981 T9740 T9737 arg1Of infection,induced
R6982 T9740 T9738 arg2Of infection,by
R6983 T9740 T9739 arg1Of infection,intranasal
R6984 T9740 T9741 arg1Of infection,with
R6985 T9744 T9741 arg2Of dose,with
R6986 T9744 T9742 arg1Of dose,a
R6987 T9744 T9743 arg1Of dose,lethal
R6988 T9744 T9745 arg1Of dose,of
R6989 T9747 T9745 arg2Of X-47,of
R699 T1430 T1432 arg1Of ",",","
R6990 T9747 T9746 arg1Of X-47,IAV
R6991 T9753 T9750 arg1Of mice,almost
R6992 T9753 T9751 arg1Of mice,all
R6993 T9753 T9752 arg1Of mice,A20myel-KO
R6994 T9753 T9754 arg1Of mice,survived
R6995 T9754 T9748 arg1Of survived,Surprisingly
R6996 T9754 T9749 arg1Of survived,","
R6997 T9754 T9755 arg1Of survived,(
R6998 T9754 T9758 arg1Of survived,","
R6999 T9754 T9759 arg1Of survived,while
R7 T77 T74 arg2Of Protects,in
R70 T139 T138 arg1Of interferon,antiviral
R700 T1431 T1430 arg2Of AP-1,","
R7000 T9756 T9755 arg2Of 10/11,(
R7001 T9757 T9755 arg3Of ),(
R7002 T9762 T9760 arg1Of mice,all
R7003 T9762 T9761 arg1Of mice,control
R7004 T9762 T9763 arg1Of mice,succumbed
R7005 T9763 T9759 arg2Of succumbed,while
R7006 T9763 T9764 arg1Of succumbed,(
R7007 T9763 T9767 arg1Of succumbed,within
R7008 T9763 T9770 arg1Of succumbed,after
R7009 T9765 T9764 arg2Of 0/11,(
R701 T1432 T1434 arg1Of ",",and
R7010 T9766 T9764 arg3Of ),(
R7011 T9769 T9767 arg2Of days,within
R7012 T9769 T9768 arg1Of days,16
R7013 T9771 T9770 arg2Of infection,after
R7014 T9771 T9772 arg1Of infection,(
R7015 T9774 T9772 arg2Of 4A,(
R7016 T9774 T9773 arg1Of 4A,figure
R7017 T9775 T9772 arg3Of ),(
R7018 T9777 T9776 arg1Of mice,A20myel-KO
R7019 T9777 T9779 arg1Of mice,showed
R702 T1433 T1432 arg2Of IRF3,","
R7020 T9777 T9808 arg1Of mice,were
R7021 T9777 T9809 arg1Of mice,able
R7022 T9777 T9811 arg1Of mice,recover
R7023 T9779 T9786 arg1Of showed,(
R7024 T9779 T9802 arg1Of showed,during
R7025 T9779 T9807 arg1Of showed,but
R7026 T9782 T9780 arg1Of loss,significant
R7027 T9782 T9781 arg1Of loss,weight
R7028 T9782 T9783 arg1Of loss,and
R7029 T9783 T9779 arg2Of and,showed
R703 T1434 T1428 arg2Of and,as
R7030 T9785 T9783 arg2Of damage,and
R7031 T9785 T9784 arg1Of damage,lung
R7032 T9787 T9786 arg2Of as,(
R7033 T9788 T9787 arg2Of reflected,as
R7034 T9793 T9788 arg1Of concentration,reflected
R7035 T9793 T9789 arg2Of concentration,by
R7036 T9793 T9790 arg2Of concentration,increased
R7037 T9793 T9791 arg1Of concentration,total
R7038 T9793 T9792 arg1Of concentration,protein
R7039 T9793 T9794 arg1Of concentration,in
R704 T1435 T1434 arg2Of IRF7,and
R7040 T9796 T9797 arg1Of BAL,;
R7041 T9797 T9794 arg2Of ;,in
R7042 T9797 T9795 arg1Of ;,the
R7043 T9798 T9797 arg2Of data,;
R7044 T9798 T9800 arg2Of data,shown
R7045 T9800 T9799 arg1Of shown,not
R7046 T9801 T9786 arg3Of ),(
R7047 T9804 T9802 arg2Of course,during
R7048 T9804 T9803 arg1Of course,the
R7049 T9804 T9805 arg1Of course,of
R705 T1435 T1436 arg1Of IRF7,[
R7050 T9806 T9805 arg2Of infection,of
R7051 T9807 T9778 arg1Of but,still
R7052 T9808 T9807 arg2Of were,but
R7053 T9808 T9812 arg1Of were,","
R7054 T9808 T9813 arg1Of were,in
R7055 T9809 T9808 arg2Of able,were
R7056 T9811 T9809 arg2Of recover,able
R7057 T9811 T9810 arg1Of recover,to
R7058 T9814 T9813 arg2Of contrast,in
R7059 T9814 T9815 arg1Of contrast,to
R706 T1437 T1436 arg2Of 1,[
R7060 T9818 T9815 arg2Of mice,to
R7061 T9818 T9816 arg1Of mice,wild
R7062 T9818 T9817 arg1Of mice,type
R7063 T9818 T9819 arg1Of mice,that
R7064 T9818 T9820 arg1Of mice,succumbed
R7065 T9823 T9820 arg2Of 4B,succumbed
R7066 T9823 T9821 arg2Of 4B,(
R7067 T9823 T9822 arg1Of 4B,figure
R7068 T9824 T9821 arg3Of ),(
R7069 T9825 T9826 arg1Of Similar,to
R707 T1438 T1436 arg3Of ],[
R7070 T9828 T9826 arg2Of observations,to
R7071 T9828 T9827 arg1Of observations,our
R7072 T9828 T9829 arg1Of observations,with
R7073 T9832 T9829 arg2Of infection,with
R7074 T9832 T9830 arg1Of infection,sublethal
R7075 T9832 T9831 arg1Of infection,IAV
R7076 T9835 T9836 arg1Of KC,and
R7077 T9837 T9836 arg2Of MIP-2,and
R7078 T9838 T9834 arg1Of production,pulmonary
R7079 T9838 T9835 arg1Of production,KC
R708 T1441 T1440 arg2Of 2,[
R7080 T9838 T9837 arg1Of production,MIP-2
R7081 T9838 T9839 arg1Of production,was
R7082 T9838 T9840 arg1Of production,stronger
R7083 T9839 T9825 arg1Of was,Similar
R7084 T9839 T9833 arg1Of was,","
R7085 T9839 T9849 arg1Of was,following
R7086 T9840 T9839 arg2Of stronger,was
R7087 T9840 T9841 arg1Of stronger,in
R7088 T9843 T9841 arg2Of animals,in
R7089 T9843 T9842 arg1Of animals,A20myel-KO
R709 T1442 T1440 arg3Of ],[
R7090 T9843 T9844 arg2Of animals,compared
R7091 T9844 T9845 arg1Of compared,to
R7092 T9848 T9845 arg2Of mice,to
R7093 T9848 T9846 arg1Of mice,wild
R7094 T9848 T9847 arg1Of mice,type
R7095 T9852 T9849 arg2Of infection,following
R7096 T9852 T9850 arg1Of infection,lethal
R7097 T9852 T9851 arg1Of infection,IAV
R7098 T9852 T9853 arg1Of infection,(
R7099 T9852 T9857 arg1Of infection,","
R71 T140 T153 arg1Of Understanding,is
R710 T1444 T1443 arg1Of presence,The
R7100 T9852 T9858 arg1Of infection,which
R7101 T9852 T9859 arg1Of infection,correlates
R7102 T9855 T9853 arg2Of 4C,(
R7103 T9855 T9854 arg1Of 4C,figure
R7104 T9856 T9853 arg3Of ),(
R7105 T9859 T9860 arg1Of correlates,with
R7106 T9863 T9860 arg2Of numbers,with
R7107 T9863 T9861 arg1Of numbers,the
R7108 T9863 T9862 arg2Of numbers,increased
R7109 T9863 T9864 arg1Of numbers,of
R711 T1444 T1445 arg1Of presence,of
R7110 T9863 T9866 arg1Of numbers,in
R7111 T9865 T9864 arg2Of neutrophils,of
R7112 T9868 T9866 arg2Of lungs,in
R7113 T9868 T9867 arg1Of lungs,the
R7114 T9868 T9869 arg1Of lungs,of
R7115 T9871 T9869 arg2Of mice,of
R7116 T9871 T9870 arg1Of mice,these
R7117 T9871 T9872 arg1Of mice,(
R7118 T9874 T9872 arg2Of 4C,(
R7119 T9874 T9873 arg1Of 4C,figure
R712 T1444 T1465 arg1Of presence,can
R7120 T9875 T9872 arg3Of ),(
R7121 T9877 T9878 arg1Of levels,of
R7122 T9877 T9887 arg1Of levels,","
R7123 T9877 T9888 arg1Of levels,which
R7124 T9877 T9889 arg1Of levels,are
R7125 T9877 T9891 arg2Of levels,associated
R7126 T9877 T9900 arg1Of levels,were
R7127 T9877 T9901 arg2Of levels,increased
R7128 T9881 T9879 arg1Of cytokines,the
R7129 T9881 T9880 arg1Of cytokines,proinflammatory
R713 T1444 T1466 arg1Of presence,be
R7130 T9882 T9883 arg1Of IL-6,","
R7131 T9883 T9885 arg1Of ",",and
R7132 T9884 T9883 arg2Of TNF,","
R7133 T9885 T9878 arg2Of and,of
R7134 T9885 T9881 arg1Of and,cytokines
R7135 T9886 T9885 arg2Of IL-1β,and
R7136 T9891 T9889 arg2Of associated,are
R7137 T9891 T9890 arg1Of associated,often
R7138 T9891 T9892 arg1Of associated,with
R7139 T9893 T9892 arg2Of immunopathogenesis,with
R714 T1444 T1467 arg2Of presence,sensed
R7140 T9893 T9894 arg1Of immunopathogenesis,in
R7141 T9895 T9894 arg2Of humans,in
R7142 T9895 T9896 arg1Of humans,[
R7143 T9897 T9896 arg2Of 64,[
R7144 T9898 T9896 arg3Of ],[
R7145 T9901 T9876 arg1Of increased,Also
R7146 T9901 T9899 arg1Of increased,","
R7147 T9901 T9900 arg2Of increased,were
R7148 T9901 T9902 arg1Of increased,in
R7149 T9901 T9908 arg1Of increased,compared
R715 T1448 T1445 arg2Of acids,of
R7150 T9904 T9902 arg2Of lungs,in
R7151 T9904 T9903 arg1Of lungs,the
R7152 T9904 T9905 arg1Of lungs,of
R7153 T9907 T9905 arg2Of mice,of
R7154 T9907 T9906 arg1Of mice,A20myel-KO
R7155 T9909 T9908 arg2Of to,compared
R7156 T9911 T9909 arg2Of animals,to
R7157 T9911 T9910 arg1Of animals,control
R7158 T9911 T9912 arg1Of animals,(
R7159 T9914 T9913 arg1Of 4C,figure
R716 T1448 T1446 arg1Of acids,viral
R7160 T9914 T9915 arg1Of 4C,and
R7161 T9915 T9912 arg2Of and,(
R7162 T9917 T9915 arg2Of S3A,and
R7163 T9917 T9916 arg1Of S3A,figure
R7164 T9918 T9912 arg3Of ),(
R7165 T9922 T9921 arg1Of production,MCP-1
R7166 T9922 T9923 arg1Of production,was
R7167 T9922 T9925 arg2Of production,increased
R7168 T9922 T9928 arg1Of production,lower
R7169 T9925 T9919 arg1Of increased,Again
R717 T1448 T1447 arg1Of acids,nucleic
R7170 T9925 T9920 arg1Of increased,","
R7171 T9925 T9923 arg2Of increased,was
R7172 T9925 T9924 arg1Of increased,not
R7173 T9925 T9926 arg1Of increased,and
R7174 T9925 T9928 modOf increased,lower
R7175 T9925 T9937 arg1Of increased,and
R7176 T9928 T9927 arg1Of lower,even
R7177 T9928 T9929 arg1Of lower,in
R7178 T9931 T9929 arg2Of mice,in
R7179 T9931 T9930 arg1Of mice,A20myel-KO
R718 T1448 T1449 arg1Of acids,","
R7180 T9931 T9932 arg1Of mice,(
R7181 T9934 T9932 arg2Of 4C,(
R7182 T9934 T9933 arg1Of 4C,figure
R7183 T9935 T9932 arg3Of ),(
R7184 T9937 T9936 arg1Of and,","
R7185 T9940 T9938 arg1Of recruitment,also
R7186 T9940 T9939 arg1Of recruitment,monocyte
R7187 T9940 T9941 arg1Of recruitment,was
R7188 T9940 T9943 arg1Of recruitment,different
R7189 T9941 T9937 arg2Of was,and
R719 T1448 T1451 arg1Of acids,as
R7190 T9941 T9942 arg1Of was,not
R7191 T9943 T9941 arg2Of different,was
R7192 T9943 T9944 arg1Of different,between
R7193 T9946 T9944 arg2Of groups,between
R7194 T9946 T9945 arg1Of groups,both
R7195 T9946 T9947 arg1Of groups,of
R7196 T9948 T9947 arg2Of mice,of
R7197 T9949 T9950 arg1Of We,could
R7198 T9949 T9953 arg1Of We,detect
R7199 T9953 T9950 arg2Of detect,could
R72 T140 T154 arg1Of Understanding,of
R720 T1451 T1450 arg1Of as,such
R7200 T9953 T9951 arg1Of detect,also
R7201 T9953 T9952 arg1Of detect,not
R7202 T9953 T9956 arg1Of detect,in
R7203 T9955 T9953 arg2Of differences,detect
R7204 T9955 T9954 arg1Of differences,any
R7205 T9958 T9957 arg1Of clearance,viral
R7206 T9958 T9959 arg1Of clearance,or
R7207 T9959 T9956 arg2Of or,in
R7208 T9959 T9963 arg1Of or,at
R7209 T9962 T9959 arg2Of immunity,or
R721 T1453 T1452 arg1Of RNA,viral
R7210 T9962 T9960 arg1Of immunity,antiviral
R7211 T9962 T9961 arg1Of immunity,adaptive
R7212 T9967 T9963 arg2Of infection,at
R7213 T9967 T9964 arg1Of infection,6
R7214 T9967 T9965 arg1Of infection,h
R7215 T9967 T9966 arg1Of infection,post
R7216 T9967 T9968 arg1Of infection,(
R7217 T9970 T9968 arg2Of S3B–F,(
R7218 T9970 T9969 arg1Of S3B–F,figure
R7219 T9971 T9968 arg3Of ),(
R722 T1453 T1454 arg1Of RNA,and
R7220 T9974 T9973 arg1Of data,these
R7221 T9974 T9975 arg1Of data,indicate
R7222 T9975 T9972 arg1Of indicate,Collectively
R7223 T9978 T9977 arg1Of deficiency,A20
R7224 T9978 T9979 arg1Of deficiency,in
R7225 T9978 T9982 arg1Of deficiency,is
R7226 T9978 T9983 arg2Of deficiency,associated
R7227 T9981 T9979 arg2Of cells,in
R7228 T9981 T9980 arg1Of cells,myeloid
R7229 T9983 T9975 arg2Of associated,indicate
R723 T1454 T1456 arg1Of and,","
R7230 T9983 T9976 arg1Of associated,that
R7231 T9983 T9982 arg2Of associated,is
R7232 T9983 T9984 arg1Of associated,with
R7233 T9989 T9986 arg2Of response,increased
R7234 T9989 T9987 arg1Of response,innate
R7235 T9989 T9988 arg1Of response,immune
R7236 T9989 T9990 arg1Of response,and
R7237 T9990 T9984 arg2Of and,with
R7238 T9990 T9985 arg1Of and,an
R7239 T9990 T9992 arg1Of and,against
R724 T1455 T1454 arg2Of DNA,and
R7240 T9991 T9990 arg2Of protection,and
R7241 T9996 T9992 arg2Of infection,against
R7242 T9996 T9993 arg1Of infection,a
R7243 T9996 T9994 arg1Of infection,lethal
R7244 T9996 T9995 arg1Of infection,IAV
R725 T1456 T1460 arg1Of ",",and
R726 T1459 T1456 arg2Of intermediates,","
R727 T1459 T1457 arg1Of intermediates,viral
R728 T1459 T1458 arg1Of intermediates,replication
R729 T1460 T1451 arg2Of and,as
R73 T142 T140 arg2Of mechanisms,Understanding
R730 T1463 T1460 arg2Of products,and
R731 T1463 T1461 arg1Of products,viral
R732 T1463 T1462 arg1Of products,transcription
R733 T1467 T1464 arg1Of sensed,","
R734 T1467 T1465 arg2Of sensed,can
R735 T1467 T1466 arg2Of sensed,be
R736 T1467 T1472 arg1Of sensed,[
R737 T1471 T1467 arg1Of PRRs,sensed
R738 T1471 T1468 arg2Of PRRs,by
R739 T1471 T1469 arg1Of PRRs,specific
R74 T142 T141 arg1Of mechanisms,the
R740 T1471 T1470 arg1Of PRRs,intracellular
R741 T1473 T1472 arg2Of 3,[
R742 T1474 T1472 arg3Of ],[
R743 T1477 T1475 arg1Of receptors,Endosomal
R744 T1477 T1476 arg1Of receptors,Toll-like
R745 T1477 T1478 arg1Of receptors,(
R746 T1477 T1481 arg1Of receptors,and
R747 T1479 T1478 arg2Of TLRs,(
R748 T1480 T1478 arg3Of ),(
R749 T1481 T1490 arg1Of and,or
R75 T142 T143 arg1Of mechanisms,that
R750 T1486 T1481 arg2Of receptors,and
R751 T1486 T1482 arg1Of receptors,cytoplasmic
R752 T1486 T1483 arg1Of receptors,RNA
R753 T1486 T1484 arg1Of receptors,helicase
R754 T1486 T1485 arg1Of receptors,RIG-I-like
R755 T1486 T1487 arg1Of receptors,(
R756 T1488 T1487 arg2Of RLRs,(
R757 T1489 T1487 arg3Of ),(
R758 T1490 T1496 arg1Of or,detect
R759 T1492 T1490 arg2Of receptors,or
R76 T142 T144 arg1Of mechanisms,regulate
R760 T1492 T1491 arg1Of receptors,Nod-like
R761 T1492 T1493 arg1Of receptors,(
R762 T1494 T1493 arg2Of NLRs,(
R763 T1495 T1493 arg3Of ),(
R764 T1498 T1496 arg2Of presence,detect
R765 T1498 T1497 arg1Of presence,the
R766 T1498 T1499 arg1Of presence,of
R767 T1502 T1500 arg1Of stranded,viral
R768 T1502 T1501 arg1Of stranded,single
R769 T1504 T1502 arg1Of TLR7,stranded
R77 T147 T144 arg2Of responses,regulate
R770 T1504 T1503 arg2Of TLR7,(
R771 T1504 T1505 arg1Of TLR7,","
R772 T1504 T1507 arg1Of TLR7,","
R773 T1504 T1510 arg1Of TLR7,or
R774 T1506 T1505 arg2Of TLR8,","
R775 T1508 T1507 arg2Of Nod2,","
R776 T1509 T1503 arg3Of ),(
R777 T1510 T1499 arg2Of or,of
R778 T1513 T1510 arg2Of RNA,or
R779 T1513 T1511 arg1Of RNA,double
R78 T147 T145 arg1Of responses,innate
R780 T1513 T1512 arg1Of RNA,stranded
R781 T1513 T1514 arg1Of RNA,(
R782 T1515 T1514 arg2Of TLR3,(
R783 T1515 T1516 arg1Of TLR3,","
R784 T1515 T1518 arg1Of TLR3,","
R785 T1517 T1516 arg2Of RIG-I,","
R786 T1519 T1518 arg2Of MDA5,","
R787 T1520 T1514 arg3Of ),(
R788 T1523 T1521 arg1Of sensors,Intracellular
R789 T1523 T1522 arg1Of sensors,DNA
R79 T147 T146 arg1Of responses,immune
R790 T1523 T1524 arg1Of sensors,that
R791 T1523 T1525 arg1Of sensors,mediate
R792 T1523 T1532 arg1Of sensors,include
R793 T1528 T1525 arg2Of responses,mediate
R794 T1528 T1526 arg1Of responses,antiviral
R795 T1528 T1527 arg1Of responses,immune
R796 T1528 T1529 arg1Of responses,to
R797 T1531 T1529 arg2Of viruses,to
R798 T1531 T1530 arg1Of viruses,DNA
R799 T1533 T1534 arg1Of TLR9,","
R8 T77 T75 arg1Of Protects,Myeloid
R80 T147 T148 arg1Of responses,to
R800 T1533 T1539 arg1Of TLR9,and
R801 T1535 T1534 arg2Of DAI,","
R802 T1535 T1536 arg1Of DAI,[
R803 T1537 T1536 arg2Of 4,[
R804 T1538 T1536 arg3Of ],[
R805 T1539 T1532 arg2Of and,include
R806 T1542 T1541 arg1Of domain,PYHIN
R807 T1542 T1543 arg1Of domain,containing
R808 T1542 T1557 arg1Of domain,and
R809 T1543 T1554 arg1Of containing,[
R81 T149 T150 arg1Of IAV,and
R810 T1545 T1543 arg2Of AIM2,containing
R811 T1545 T1544 arg1Of AIM2,proteins
R812 T1545 T1546 arg1Of AIM2,[
R813 T1545 T1549 arg1Of AIM2,","
R814 T1545 T1550 arg1Of AIM2,[
R815 T1545 T1553 arg1Of AIM2,","
R816 T1547 T1546 arg2Of 5,[
R817 T1548 T1546 arg3Of ],[
R818 T1551 T1550 arg2Of 6,[
R819 T1552 T1550 arg3Of ],[
R82 T150 T148 arg2Of and,to
R820 T1555 T1554 arg2Of 7,[
R821 T1556 T1554 arg3Of ],[
R822 T1557 T1539 arg2Of and,and
R823 T1557 T1540 arg1Of and,the
R824 T1558 T1557 arg2Of IFI16,and
R825 T1558 T1559 arg1Of IFI16,[
R826 T1560 T1559 arg2Of 8,[
R827 T1561 T1559 arg3Of ],[
R828 T1565 T1563 arg2Of responses,mediated
R829 T1565 T1564 arg1Of responses,antiviral
R83 T152 T150 arg2Of viruses,and
R830 T1565 T1566 arg1Of responses,are
R831 T1565 T1567 arg1Of responses,restricted
R832 T1566 T1562 arg1Of are,TLR
R833 T1567 T1566 arg2Of restricted,are
R834 T1567 T1568 arg1Of restricted,to
R835 T1572 T1568 arg2Of IFN,to
R836 T1572 T1569 arg2Of IFN,specialized
R837 T1572 T1570 arg1Of IFN,type
R838 T1572 T1571 arg1Of IFN,I
R839 T1572 T1573 arg1Of IFN,producing
R84 T152 T151 arg1Of viruses,other
R840 T1573 T1580 arg1Of producing,","
R841 T1573 T1581 arg1Of producing,while
R842 T1576 T1573 arg2Of cells,producing
R843 T1576 T1574 arg1Of cells,plasmacytoid
R844 T1576 T1575 arg1Of cells,dendritic
R845 T1576 T1577 arg1Of cells,(
R846 T1578 T1577 arg2Of pDC,(
R847 T1579 T1577 arg3Of ),(
R848 T1585 T1582 arg1Of types,most
R849 T1585 T1583 arg1Of types,other
R85 T153 T157 modOf is,to
R850 T1585 T1584 arg1Of types,cell
R851 T1585 T1586 arg1Of types,","
R852 T1585 T1587 arg1Of types,including
R853 T1585 T1593 arg1Of types,","
R8532 T12002 T11999 arg2Of study,In
R8533 T12002 T12000 arg1Of study,the
R8534 T12002 T12001 arg1Of study,present
R8535 T12003 T12004 arg1Of we,have
R8536 T12003 T12005 arg1Of we,investigated
R8537 T12005 T11999 arg1Of investigated,In
R8538 T12005 T12004 arg2Of investigated,have
R8539 T12005 T12014 arg1Of investigated,in
R854 T1589 T1587 arg2Of DC,including
R8540 T12007 T12005 arg2Of contribution,investigated
R8541 T12007 T12006 arg1Of contribution,the
R8542 T12007 T12008 arg1Of contribution,of
R8543 T12010 T12008 arg2Of expression,of
R8544 T12010 T12009 arg1Of expression,A20
R8545 T12010 T12011 arg1Of expression,in
R8546 T12013 T12011 arg2Of cells,in
R8547 T12013 T12012 arg1Of cells,myeloid
R8548 T12018 T12014 arg2Of response,in
R8549 T12018 T12015 arg1Of response,the
R855 T1589 T1588 arg1Of DC,conventional
R8550 T12018 T12016 arg1Of response,innate
R8551 T12018 T12017 arg1Of response,immune
R8552 T12018 T12019 arg1Of response,to
R8553 T12022 T12019 arg2Of infection,to
R8554 T12022 T12020 arg1Of infection,IAV
R8555 T12022 T12021 arg1Of infection,lung
R8556 T12026 T12023 arg2Of environment,In
R8557 T12026 T12024 arg1Of environment,the
R8558 T12026 T12025 arg1Of environment,pulmonary
R8559 T12028 T12029 arg1Of macrophages,populate
R856 T1589 T1590 arg1Of DC,(
R8560 T12029 T12023 arg1Of populate,In
R8561 T12029 T12027 arg1Of populate,","
R8562 T12032 T12030 arg1Of parenchyma,both
R8563 T12032 T12031 arg1Of parenchyma,lung
R8564 T12032 T12033 arg1Of parenchyma,and
R8565 T12033 T12029 arg2Of and,populate
R8566 T12036 T12033 arg2Of lumen,and
R8567 T12036 T12034 arg1Of lumen,the
R8568 T12036 T12035 arg1Of lumen,alveolar
R8569 T12036 T12037 arg1Of lumen,where
R857 T1591 T1590 arg2Of cDC,(
R8570 T12038 T12039 arg1Of they,are
R8571 T12038 T12040 arg2Of they,referred
R8572 T12040 T12037 arg2Of referred,where
R8573 T12040 T12039 arg2Of referred,are
R8574 T12040 T12041 arg1Of referred,to
R8575 T12040 T12042 arg1Of referred,as
R8576 T12044 T12042 arg2Of macrophages,as
R8577 T12044 T12043 arg1Of macrophages,alveolar
R8578 T12047 T12045 arg2Of conditions,Under
R8579 T12047 T12046 arg1Of conditions,naïve
R858 T1592 T1590 arg3Of ),(
R8580 T12050 T12049 arg1Of macrophages,alveolar
R8581 T12050 T12051 arg1Of macrophages,exert
R8582 T12051 T12045 arg1Of exert,Under
R8583 T12051 T12048 arg1Of exert,","
R8584 T12051 T12058 arg1Of exert,","
R8585 T12051 T12059 arg1Of exert,[
R8586 T12054 T12051 arg2Of functions,exert
R8587 T12054 T12052 arg1Of functions,important
R8588 T12054 T12053 arg1Of functions,immunomodulatory
R8589 T12054 T12055 arg1Of functions,[
R859 T1593 T1598 arg1Of ",",depend
R8590 T12056 T12055 arg2Of 65,[
R8591 T12057 T12055 arg3Of ],[
R8592 T12060 T12059 arg2Of 66,[
R8593 T12061 T12059 arg3Of ],[
R8594 T12065 T12064 arg1Of macrophages,alveolar
R8595 T12065 T12066 arg1Of macrophages,are
R8596 T12065 T12068 arg1Of macrophages,crucial
R8597 T12066 T12062 arg1Of are,However
R8598 T12066 T12063 arg1Of are,","
R8599 T12066 T12067 arg1Of are,also
R86 T154 T153 arg2Of of,is
R860 T1594 T1595 arg1Of macrophages,and
R8600 T12066 T12069 arg1Of are,in
R8601 T12066 T12076 arg1Of are,as
R8602 T12068 T12066 arg2Of crucial,are
R8603 T12073 T12069 arg2Of response,in
R8604 T12073 T12070 arg1Of response,the
R8605 T12073 T12071 arg1Of response,innate
R8606 T12073 T12072 arg1Of response,immune
R8607 T12073 T12074 arg1Of response,against
R8608 T12075 T12074 arg2Of IAV,against
R8609 T12077 T12078 arg1Of they,are
R861 T1595 T1593 arg2Of and,","
R8610 T12078 T12076 arg2Of are,as
R8611 T12079 T12078 arg2Of one,are
R8612 T12079 T12080 arg1Of one,of
R8613 T12083 T12080 arg2Of cells,of
R8614 T12083 T12081 arg1Of cells,the
R8615 T12083 T12082 arg1Of cells,first
R8616 T12083 T12084 arg1Of cells,that
R8617 T12083 T12085 arg1Of cells,encounter
R8618 T12085 T12092 arg1Of encounter,","
R8619 T12085 T12093 arg1Of encounter,[
R862 T1596 T1595 arg2Of fibroblasts,and
R8620 T12088 T12085 arg2Of particles,encounter
R8621 T12088 T12086 arg1Of particles,infectious
R8622 T12088 T12087 arg1Of particles,IAV
R8623 T12088 T12089 arg1Of particles,[
R8624 T12090 T12089 arg2Of 67,[
R8625 T12091 T12089 arg3Of ],[
R8626 T12094 T12093 arg2Of 68,[
R8627 T12095 T12093 arg3Of ],[
R8628 T12096 T12097 arg1Of They,are
R8629 T12097 T12124 arg1Of are,and
R863 T1598 T1581 arg2Of depend,while
R8630 T12100 T12097 arg2Of source,are
R8631 T12100 T12098 arg1Of source,an
R8632 T12100 T12099 arg1Of source,important
R8633 T12100 T12101 arg1Of source,of
R8634 T12103 T12104 arg1Of cytokines,and
R8635 T12104 T12101 arg2Of and,of
R8636 T12104 T12102 arg1Of and,proinflammatory
R8637 T12104 T12106 arg1Of and,that
R8638 T12104 T12107 arg1Of and,attract
R8639 T12105 T12104 arg2Of chemokines,and
R864 T1598 T1597 arg1Of depend,","
R8640 T12107 T12114 arg1Of attract,during
R8641 T12110 T12107 arg2Of cells,attract
R8642 T12110 T12108 arg1Of cells,innate
R8643 T12110 T12109 arg1Of cells,immune
R8644 T12110 T12111 arg1Of cells,to
R8645 T12113 T12111 arg2Of lung,to
R8646 T12113 T12112 arg1Of lung,the
R8647 T12117 T12114 arg2Of phase,during
R8648 T12117 T12115 arg1Of phase,the
R8649 T12117 T12116 arg1Of phase,primary
R865 T1598 T1599 arg1Of depend,on
R8650 T12117 T12118 arg1Of phase,of
R8651 T12119 T12118 arg2Of infection,of
R8652 T12119 T12120 arg1Of infection,[
R8653 T12121 T12120 arg2Of 69,[
R8654 T12122 T12120 arg3Of ],[
R8655 T12124 T12123 arg1Of and,","
R8656 T12125 T12126 arg1Of they,are
R8657 T12126 T12124 arg2Of are,and
R8658 T12129 T12126 arg2Of producers,are
R8659 T12129 T12127 arg1Of producers,the
R866 T1602 T1603 arg1Of RNA,and
R8660 T12129 T12128 arg1Of producers,primary
R8661 T12129 T12130 arg1Of producers,of
R8662 T12133 T12130 arg2Of IFNs,of
R8663 T12133 T12131 arg1Of IFNs,type
R8664 T12133 T12132 arg1Of IFNs,I
R8665 T12133 T12134 arg1Of IFNs,[
R8666 T12135 T12134 arg2Of 70,[
R8667 T12136 T12134 arg3Of ],[
R8668 T12138 T12137 arg1Of macrophages,Alveolar
R8669 T12138 T12139 arg1Of macrophages,are
R867 T1604 T1603 arg2Of DNA,and
R8670 T12138 T12141 arg2Of macrophages,known
R8671 T12138 T12143 arg1Of macrophages,phagocytose
R8672 T12141 T12139 arg2Of known,are
R8673 T12141 T12140 arg1Of known,also
R8674 T12141 T12148 arg1Of known,and
R8675 T12143 T12141 arg3Of phagocytose,known
R8676 T12143 T12142 arg1Of phagocytose,to
R8677 T12147 T12143 arg2Of cells,phagocytose
R8678 T12147 T12144 arg1Of cells,virus
R8679 T12147 T12145 arg1Of cells,infected
R868 T1605 T1599 arg2Of sensors,on
R8680 T12147 T12146 arg1Of cells,apoptotic
R8681 T12149 T12150 arg1Of antibody,coated
R8682 T12149 T12155 arg1Of antibody,contributing
R8683 T12150 T12148 arg2Of coated,and
R8684 T12150 T12153 arg1Of coated,","
R8685 T12150 T12155 modOf coated,contributing
R8686 T12152 T12150 arg2Of particles,coated
R8687 T12152 T12151 arg1Of particles,viral
R8688 T12155 T12154 arg1Of contributing,further
R8689 T12155 T12156 arg1Of contributing,to
R869 T1605 T1600 arg1Of sensors,the
R8690 T12158 T12156 arg2Of clearance,to
R8691 T12158 T12157 arg1Of clearance,viral
R8692 T12159 T12160 arg1Of We,could
R8693 T12159 T12161 arg1Of We,show
R8694 T12161 T12160 arg2Of show,could
R8695 T12163 T12164 arg1Of BMDM,or
R8696 T12165 T12164 arg2Of alveolar,or
R8697 T12166 T12163 arg1Of macrophages,BMDM
R8698 T12166 T12165 arg1Of macrophages,alveolar
R8699 T12166 T12167 arg2Of macrophages,derived
R87 T156 T154 arg2Of importance,of
R870 T1605 T1601 arg1Of sensors,cytosolic
R8700 T12166 T12171 arg1Of macrophages,express
R8701 T12167 T12168 arg1Of derived,from
R8702 T12170 T12168 arg2Of mice,from
R8703 T12170 T12169 arg1Of mice,A20myel-KO
R8704 T12171 T12161 arg2Of express,show
R8705 T12171 T12162 arg1Of express,that
R8706 T12171 T12182 arg1Of express,compared
R8707 T12171 T12187 arg1Of express,in
R8708 T12173 T12171 arg2Of amounts,express
R8709 T12173 T12172 arg1Of amounts,higher
R871 T1605 T1602 arg1Of sensors,RNA
R8710 T12173 T12174 arg1Of amounts,of
R8711 T12175 T12176 arg1Of chemokines,","
R8712 T12176 T12178 arg1Of ",",and
R8713 T12177 T12176 arg2Of cytokines,","
R8714 T12178 T12174 arg2Of and,of
R8715 T12181 T12178 arg2Of IFNs,and
R8716 T12181 T12179 arg1Of IFNs,type
R8717 T12181 T12180 arg1Of IFNs,I
R8718 T12183 T12182 arg2Of to,compared
R8719 T12186 T12183 arg2Of mice,to
R872 T1605 T1604 arg1Of sensors,DNA
R8720 T12186 T12184 arg1Of mice,wild
R8721 T12186 T12185 arg1Of mice,type
R8722 T12188 T12187 arg2Of response,in
R8723 T12188 T12189 arg1Of response,to
R8724 T12191 T12190 arg1Of vitro,in
R8725 T12192 T12189 arg2Of infection,to
R8726 T12192 T12191 arg1Of infection,vitro
R8727 T12196 T12195 arg1Of vivo,in
R8728 T12197 T12196 arg1Of infection,vivo
R8729 T12197 T12198 arg1Of infection,with
R873 T1605 T1606 arg1Of sensors,for
R8730 T12197 T12200 arg1Of infection,resulted
R8731 T12199 T12198 arg2Of IAV,with
R8732 T12200 T12193 arg1Of resulted,Similarly
R8733 T12200 T12194 arg1Of resulted,","
R8734 T12200 T12201 arg1Of resulted,in
R8735 T12203 T12201 arg2Of levels,in
R8736 T12203 T12202 arg1Of levels,higher
R8737 T12203 T12204 arg1Of levels,of
R8738 T12206 T12204 arg2Of neutrophil,of
R8739 T12206 T12205 arg1Of neutrophil,primarily
R874 T1608 T1606 arg2Of production,for
R8740 T12206 T12207 arg1Of neutrophil,attracting
R8741 T12208 T12207 arg2Of chemokines,attracting
R8742 T12208 T12210 arg1Of chemokines,as
R8743 T12208 T12225 arg1Of chemokines,in
R8744 T12210 T12209 arg1Of as,such
R8745 T12211 T12212 arg1Of KC,and
R8746 T12212 T12214 arg1Of and,and
R8747 T12213 T12212 arg2Of MIP-2,and
R8748 T12214 T12210 arg2Of and,as
R8749 T12217 T12214 arg2Of cytokines,and
R875 T1608 T1607 arg1Of production,the
R8750 T12217 T12215 arg1Of cytokines,several
R8751 T12217 T12216 arg1Of cytokines,proinflammatory
R8752 T12217 T12219 arg1Of cytokines,as
R8753 T12219 T12218 arg1Of as,such
R8754 T12220 T12221 arg1Of IL-6,","
R8755 T12221 T12223 arg1Of ",",and
R8756 T12222 T12221 arg2Of TNF,","
R8757 T12223 T12219 arg2Of and,as
R8758 T12224 T12223 arg2Of IL-1β,and
R8759 T12227 T12225 arg2Of lungs,in
R876 T1608 T1609 arg1Of production,of
R8760 T12227 T12226 arg1Of lungs,the
R8761 T12227 T12228 arg1Of lungs,of
R8762 T12230 T12228 arg2Of mice,of
R8763 T12230 T12229 arg1Of mice,A20myel-KO
R8764 T12230 T12231 arg2Of mice,compared
R8765 T12231 T12232 arg1Of compared,to
R8766 T12235 T12232 arg2Of mice,to
R8767 T12235 T12233 arg1Of mice,wild
R8768 T12235 T12234 arg1Of mice,type
R8769 T12236 T12237 arg1Of This,was
R877 T1608 T1612 arg1Of production,[
R8770 T12236 T12238 arg2Of This,associated
R8771 T12236 T12252 arg1Of This,resulted
R8772 T12238 T12237 arg2Of associated,was
R8773 T12238 T12239 arg1Of associated,with
R8774 T12238 T12251 arg1Of associated,and
R8775 T12242 T12239 arg2Of enhancement,with
R8776 T12242 T12240 arg1Of enhancement,a
R8777 T12242 T12241 arg1Of enhancement,selective
R8778 T12242 T12243 arg1Of enhancement,of
R8779 T12245 T12243 arg2Of recruitment,of
R878 T1611 T1609 arg2Of proteins,of
R8780 T12245 T12244 arg1Of recruitment,neutrophil
R8781 T12245 T12246 arg1Of recruitment,to
R8782 T12249 T12246 arg2Of compartment,to
R8783 T12249 T12247 arg1Of compartment,the
R8784 T12249 T12248 arg1Of compartment,bronchoalveolar
R8785 T12251 T12250 arg1Of and,","
R8786 T12252 T12251 arg2Of resulted,and
R8787 T12252 T12253 arg1Of resulted,in
R8788 T12252 T12257 arg1Of resulted,later
R8789 T12252 T12259 arg1Of resulted,during
R879 T1611 T1610 arg1Of proteins,antiviral
R8790 T12256 T12253 arg2Of clearance,in
R8791 T12256 T12254 arg2Of clearance,improved
R8792 T12256 T12255 arg1Of clearance,viral
R8793 T12257 T12258 arg1Of later,on
R8794 T12260 T12259 arg2Of infection,during
R8795 T12263 T12262 arg1Of role,the
R8796 T12263 T12264 arg1Of role,of
R8797 T12263 T12266 arg1Of role,during
R8798 T12263 T12269 arg1Of role,is
R8799 T12263 T12271 arg1Of role,under
R88 T156 T155 arg1Of importance,key
R880 T1613 T1612 arg2Of 9,[
R8800 T12265 T12264 arg2Of neutrophils,of
R8801 T12268 T12266 arg2Of infection,during
R8802 T12268 T12267 arg1Of infection,viral
R8803 T12269 T12261 arg2Of is,Although
R8804 T12269 T12270 arg1Of is,still
R8805 T12271 T12269 arg2Of under,is
R8806 T12272 T12271 arg2Of debate,under
R8807 T12275 T12274 arg1Of evidence,recent
R8808 T12275 T12276 arg1Of evidence,supports
R8809 T12276 T12261 arg1Of supports,Although
R881 T1614 T1612 arg3Of ],[
R8810 T12276 T12273 arg1Of supports,","
R8811 T12276 T12283 arg1Of supports,during
R8812 T12276 T12289 arg1Of supports,","
R8813 T12276 T12290 arg1Of supports,[
R8814 T12279 T12276 arg2Of function,supports
R8815 T12279 T12277 arg1Of function,a
R8816 T12279 T12278 arg1Of function,protective
R8817 T12279 T12280 arg1Of function,of
R8818 T12282 T12280 arg2Of cells,of
R8819 T12282 T12281 arg1Of cells,these
R882 T1617 T1615 arg1Of virus,Influenza
R8820 T12285 T12283 arg2Of infection,during
R8821 T12285 T12284 arg1Of infection,IAV
R8822 T12285 T12286 arg1Of infection,[
R8823 T12287 T12286 arg2Of 71,[
R8824 T12288 T12286 arg3Of ],[
R8825 T12291 T12290 arg2Of 72,[
R8826 T12292 T12290 arg3Of ],[
R8827 T12294 T12293 arg1Of levels,MCP-1
R8828 T12294 T12295 arg1Of levels,were
R8829 T12294 T12297 arg2Of levels,affected
R883 T1617 T1616 arg1Of virus,A
R8830 T12297 T12295 arg2Of affected,were
R8831 T12297 T12296 arg1Of affected,not
R8832 T12300 T12297 arg1Of absence,affected
R8833 T12300 T12298 arg2Of absence,by
R8834 T12300 T12299 arg1Of absence,the
R8835 T12300 T12301 arg1Of absence,of
R8836 T12300 T12303 arg1Of absence,in
R8837 T12300 T12306 arg1Of absence,","
R8838 T12300 T12307 arg1Of absence,which
R8839 T12300 T12308 arg1Of absence,is
R884 T1617 T1618 arg1Of virus,(
R8840 T12300 T12309 arg1Of absence,consistent
R8841 T12302 T12301 arg2Of A20,of
R8842 T12305 T12303 arg2Of cells,in
R8843 T12305 T12304 arg1Of cells,myeloid
R8844 T12309 T12308 arg2Of consistent,is
R8845 T12309 T12310 arg1Of consistent,with
R8846 T12312 T12310 arg2Of notion,with
R8847 T12312 T12311 arg1Of notion,the
R8848 T12316 T12314 arg1Of cells,airway
R8849 T12316 T12315 arg1Of cells,epithelial
R885 T1617 T1621 arg1Of virus,is
R8850 T12316 T12317 arg1Of cells,are
R8851 T12317 T12312 arg2Of are,notion
R8852 T12317 T12313 arg1Of are,that
R8853 T12317 T12327 arg1Of are,[
R8854 T12320 T12317 arg2Of source,are
R8855 T12320 T12318 arg1Of source,the
R8856 T12320 T12319 arg1Of source,primary
R8857 T12320 T12321 arg1Of source,of
R8858 T12320 T12324 arg1Of source,during
R8859 T12323 T12321 arg2Of production,of
R886 T1619 T1618 arg2Of IAV,(
R8860 T12323 T12322 arg1Of production,MCP-1
R8861 T12326 T12324 arg2Of infection,during
R8862 T12326 T12325 arg1Of infection,IAV
R8863 T12328 T12327 arg2Of 73,[
R8864 T12329 T12327 arg3Of ],[
R8865 T12330 T12331 arg1Of Mice,deficient
R8866 T12330 T12348 arg1Of Mice,are
R8867 T12330 T12349 arg2Of Mice,protected
R8868 T12331 T12332 arg1Of deficient,for
R8869 T12336 T12332 arg2Of CCR2,for
R887 T1620 T1618 arg3Of ),(
R8870 T12336 T12333 arg1Of CCR2,the
R8871 T12336 T12334 arg1Of CCR2,MCP-1
R8872 T12336 T12335 arg1Of CCR2,receptor
R8873 T12336 T12337 arg1Of CCR2,","
R8874 T12336 T12338 arg1Of CCR2,which
R8875 T12336 T12339 arg1Of CCR2,is
R8876 T12336 T12340 arg2Of CCR2,expressed
R8877 T12340 T12339 arg2Of expressed,is
R8878 T12340 T12341 arg1Of expressed,on
R8879 T12343 T12341 arg2Of subset,on
R888 T1624 T1621 arg2Of agent,is
R8880 T12343 T12342 arg1Of subset,a
R8881 T12343 T12344 arg1Of subset,of
R8882 T12346 T12344 arg2Of monocytes,of
R8883 T12346 T12345 arg1Of monocytes,circulating
R8884 T12349 T12347 arg1Of protected,","
R8885 T12349 T12348 arg2Of protected,are
R8886 T12349 T12350 arg1Of protected,against
R8887 T12352 T12351 arg1Of infection,IAV
R8888 T12352 T12353 arg1Of infection,and
R8889 T12353 T12350 arg2Of and,against
R889 T1624 T1622 arg1Of agent,the
R8890 T12356 T12353 arg2Of signs,and
R8891 T12356 T12354 arg1Of signs,display
R8892 T12356 T12355 arg2Of signs,reduced
R8893 T12356 T12357 arg1Of signs,of
R8894 T12360 T12359 arg2Of 74,[
R8895 T12361 T12359 arg3Of ],[
R8896 T12362 T12357 arg2Of –,of
R8897 T12362 T12358 arg1Of –,immunopathology
R8898 T12362 T12359 arg1Of –,[
R8899 T12362 T12363 arg1Of –,[
R89 T158 T157 arg1Of develop,to
R890 T1624 T1623 arg1Of agent,etiological
R8900 T12364 T12363 arg2Of 76,[
R8901 T12365 T12363 arg3Of ],[
R8902 T12368 T12366 arg2Of infection,During
R8903 T12368 T12367 arg1Of infection,IAV
R8904 T12370 T12369 arg1Of monocytes,these
R8905 T12370 T12371 arg1Of monocytes,develop
R8906 T12370 T12383 arg1Of monocytes,are
R8907 T12370 T12384 arg2Of monocytes,considered
R8908 T12371 T12372 arg1Of develop,into
R8909 T12371 T12382 arg1Of develop,and
R891 T1624 T1625 arg1Of agent,of
R8910 T12375 T12373 arg1Of cells,inflammatory
R8911 T12375 T12374 arg1Of cells,dendritic
R8912 T12375 T12376 arg1Of cells,or
R8913 T12376 T12372 arg2Of or,into
R8914 T12378 T12376 arg2Of macrophages,or
R8915 T12378 T12377 arg1Of macrophages,proinflammatory
R8916 T12378 T12379 arg1Of macrophages,[
R8917 T12380 T12379 arg2Of 77,[
R8918 T12381 T12379 arg3Of ],[
R8919 T12382 T12366 arg1Of and,During
R892 T1630 T1625 arg2Of disease,of
R8920 T12384 T12382 arg2Of considered,and
R8921 T12384 T12383 arg2Of considered,are
R8922 T12386 T12384 arg3Of contributors,considered
R8923 T12386 T12385 arg1Of contributors,major
R8924 T12386 T12387 arg1Of contributors,to
R8925 T12389 T12387 arg2Of immunopathology,to
R8926 T12389 T12388 arg1Of immunopathology,IAV-induced
R8927 T12389 T12390 arg1Of immunopathology,[
R8928 T12391 T12390 arg2Of 78,[
R8929 T12392 T12390 arg3Of ],[
R893 T1630 T1626 arg1Of disease,a
R8930 T12394 T12393 arg1Of mice,A20myel-KO
R8931 T12394 T12395 arg1Of mice,were
R8932 T12394 T12396 arg2Of mice,protected
R8933 T12396 T12395 arg2Of protected,were
R8934 T12396 T12397 arg1Of protected,against
R8935 T12401 T12397 arg2Of infection,against
R8936 T12401 T12398 arg1Of infection,a
R8937 T12401 T12399 arg1Of infection,lethal
R8938 T12401 T12400 arg1Of infection,IAV
R8939 T12401 T12402 arg1Of infection,","
R894 T1630 T1627 arg1Of disease,contagious
R8940 T12401 T12403 arg1Of infection,which
R8941 T12401 T12404 arg1Of infection,is
R8942 T12401 T12406 arg1Of infection,surprising
R8943 T12404 T12407 arg1Of is,since
R8944 T12406 T12404 arg2Of surprising,is
R8945 T12406 T12405 arg1Of surprising,rather
R8946 T12412 T12408 arg1Of response,an
R8947 T12412 T12409 arg1Of response,excessive
R8948 T12412 T12410 arg1Of response,proinflammatory
R8949 T12412 T12411 arg1Of response,cytokine
R895 T1630 T1628 arg1Of disease,acute
R8950 T12412 T12413 arg1Of response,and
R8951 T12413 T12420 arg1Of and,is
R8952 T12413 T12422 arg2Of and,believed
R8953 T12413 T12424 arg1Of and,be
R8954 T12413 T12425 arg2Of and,associated
R8955 T12416 T12413 arg2Of influx,and
R8956 T12416 T12414 arg1Of influx,an
R8957 T12416 T12415 arg1Of influx,excessive
R8958 T12416 T12417 arg1Of influx,of
R8959 T12419 T12417 arg2Of cells,of
R896 T1630 T1629 arg1Of disease,respiratory
R8960 T12419 T12418 arg1Of cells,inflammatory
R8961 T12422 T12407 arg2Of believed,since
R8962 T12422 T12420 arg2Of believed,is
R8963 T12422 T12421 arg1Of believed,generally
R8964 T12422 T12432 arg1Of believed,","
R8965 T12422 T12433 arg1Of believed,[
R8966 T12425 T12422 arg3Of associated,believed
R8967 T12425 T12423 arg1Of associated,to
R8968 T12425 T12424 arg2Of associated,be
R8969 T12425 T12426 arg1Of associated,with
R897 T1630 T1631 arg1Of disease,that
R8970 T12428 T12426 arg2Of lethality,with
R8971 T12428 T12427 arg2Of lethality,increased
R8972 T12428 T12429 arg1Of lethality,[
R8973 T12430 T12429 arg2Of 64,[
R8974 T12431 T12429 arg3Of ],[
R8975 T12434 T12433 arg2Of 79,[
R8976 T12435 T12433 arg3Of ],[
R8977 T12440 T12438 arg1Of effect,the
R8978 T12440 T12439 arg1Of effect,selective
R8979 T12440 T12441 arg1Of effect,of
R898 T1630 T1632 arg1Of disease,causes
R8980 T12440 T12444 arg1Of effect,on
R8981 T12440 T12449 arg1Of effect,altering
R8982 T12440 T12459 arg1Of effect,support
R8983 T12443 T12441 arg2Of deficiency,of
R8984 T12443 T12442 arg1Of deficiency,A20
R8985 T12446 T12444 arg2Of recruitment,on
R8986 T12446 T12445 arg1Of recruitment,neutrophil
R8987 T12449 T12448 arg2Of altering,without
R8988 T12451 T12450 arg1Of monocyte,inflammatory
R8989 T12451 T12452 arg1Of monocyte,(
R899 T1634 T1632 arg2Of mortality,causes
R8990 T12454 T12452 arg2Of CD11b+,(
R8991 T12454 T12453 arg1Of CD11b+,Ly6C+
R8992 T12455 T12452 arg3Of ),(
R8993 T12456 T12449 arg2Of recruitment,altering
R8994 T12456 T12451 arg1Of recruitment,monocyte
R8995 T12459 T12436 arg1Of support,However
R8996 T12459 T12437 arg1Of support,","
R8997 T12459 T12447 arg1Of support,","
R8998 T12459 T12448 arg1Of support,without
R8999 T12459 T12457 arg1Of support,","
R9 T77 T76 arg1Of Protects,Cells
R90 T161 T158 arg2Of strategies,develop
R900 T1634 T1633 arg1Of mortality,considerable
R9000 T12459 T12458 arg1Of support,further
R9001 T12461 T12459 arg2Of idea,support
R9002 T12461 T12460 arg1Of idea,the
R9003 T12463 T12464 arg1Of monocytes,and
R9004 T12464 T12467 arg1Of and,are
R9005 T12466 T12464 arg2Of neutrophils,and
R9006 T12466 T12465 arg1Of neutrophils,not
R9007 T12467 T12461 arg2Of are,idea
R9008 T12467 T12462 arg1Of are,that
R9009 T12469 T12467 arg2Of contributors,are
R901 T1634 T1635 arg1Of mortality,","
R9010 T12469 T12468 arg1Of contributors,major
R9011 T12469 T12470 arg1Of contributors,to
R9012 T12472 T12471 arg1Of immunopathology,IAV-associated
R9013 T12472 T12473 arg1Of immunopathology,and
R9014 T12473 T12470 arg2Of and,to
R9015 T12474 T12473 arg2Of lethality,and
R9016 T12474 T12475 arg1Of lethality,[
R9017 T12476 T12475 arg2Of 78,[
R9018 T12477 T12475 arg3Of ],[
R9019 T12478 T12479 arg1Of We,show
R902 T1634 T1636 arg1Of mortality,which
R9020 T12484 T12481 arg1Of display,A20
R9021 T12484 T12482 arg1Of display,deficient
R9022 T12484 T12483 arg1Of display,BMDM
R9023 T12484 T12485 arg1Of display,enhanced
R9024 T12485 T12479 arg2Of enhanced,show
R9025 T12485 T12480 arg1Of enhanced,that
R9026 T12486 T12487 arg1Of NF-κB,and
R9027 T12488 T12487 arg2Of IRF3,and
R9028 T12489 T12485 arg2Of activation,enhanced
R9029 T12489 T12486 arg1Of activation,NF-κB
R903 T1634 T1637 arg1Of mortality,is
R9030 T12489 T12488 arg1Of activation,IRF3
R9031 T12489 T12490 arg1Of activation,in
R9032 T12489 T12495 arg1Of activation,by
R9033 T12490 T12492 arg1Of in,to
R9034 T12491 T12490 arg2Of response,in
R9035 T12494 T12490 arg3Of stimulation,in
R9036 T12494 T12493 arg1Of stimulation,RIG-I
R9037 T12498 T12496 arg1Of double,synthetic
R9038 T12498 T12497 arg1Of double,LMW
R9039 T12500 T12495 arg2Of RNA,by
R904 T1634 T1639 arg2Of mortality,believed
R9040 T12500 T12498 arg1Of RNA,double
R9041 T12500 T12499 arg1Of RNA,stranded
R9042 T12501 T12502 arg1Of RIG-I,has
R9043 T12501 T12504 arg1Of RIG-I,been
R9044 T12501 T12505 arg2Of RIG-I,shown
R9045 T12501 T12507 arg1Of RIG-I,play
R9046 T12505 T12502 arg2Of shown,has
R9047 T12505 T12503 arg1Of shown,previously
R9048 T12505 T12504 arg2Of shown,been
R9049 T12507 T12505 arg3Of play,shown
R905 T1634 T1641 arg1Of mortality,be
R9050 T12507 T12506 arg1Of play,to
R9051 T12507 T12511 arg1Of play,in
R9052 T12507 T12521 arg1Of play,","
R9053 T12507 T12522 modOf play,suggesting
R9054 T12510 T12507 arg2Of role,play
R9055 T12510 T12508 arg1Of role,a
R9056 T12510 T12509 arg1Of role,key
R9057 T12515 T12511 arg2Of response,in
R9058 T12515 T12512 arg1Of response,the
R9059 T12515 T12513 arg1Of response,innate
R906 T1634 T1643 arg1Of mortality,to
R9060 T12515 T12514 arg1Of response,immune
R9061 T12515 T12516 arg1Of response,to
R9062 T12517 T12516 arg2Of IAV,to
R9063 T12517 T12518 arg1Of IAV,[
R9064 T12519 T12518 arg2Of 13,[
R9065 T12520 T12518 arg3Of ],[
R9066 T12527 T12524 arg1Of response,the
R9067 T12527 T12525 arg2Of response,increased
R9068 T12527 T12526 arg1Of response,immune
R9069 T12527 T12528 arg1Of response,of
R907 T1639 T1637 arg2Of believed,is
R9070 T12527 T12531 arg1Of response,to
R9071 T12527 T12535 arg1Of response,reflects
R9072 T12530 T12528 arg2Of mice,of
R9073 T12530 T12529 arg1Of mice,A20myel-KO
R9074 T12534 T12531 arg2Of infection,to
R9075 T12534 T12532 arg1Of infection,IAV
R9076 T12534 T12533 arg1Of infection,lung
R9077 T12535 T12522 arg2Of reflects,suggesting
R9078 T12535 T12523 arg1Of reflects,that
R9079 T12538 T12535 arg2Of signaling,reflects
R908 T1639 T1638 arg1Of believed,generally
R9080 T12538 T12536 arg2Of signaling,enhanced
R9081 T12538 T12537 arg1Of signaling,RIG-I
R9082 T12539 T12540 arg1Of We,propose
R9083 T12542 T12543 arg1Of A20,inhibits
R9084 T12543 T12540 arg2Of inhibits,propose
R9085 T12543 T12541 arg1Of inhibits,that
R9086 T12543 T12548 arg1Of inhibits,(
R9087 T12543 T12566 arg1Of inhibits,by
R9088 T12547 T12543 arg2Of expression,inhibits
R9089 T12547 T12544 arg1Of expression,IAV-induced
R909 T1641 T1639 arg3Of be,believed
R9090 T12547 T12545 arg1Of expression,proinflammatory
R9091 T12547 T12546 arg1Of expression,gene
R9092 T12549 T12548 arg2Of as,(
R9093 T12550 T12549 arg2Of shown,as
R9094 T12550 T12551 arg1Of shown,in
R9095 T12553 T12551 arg2Of manuscript,in
R9096 T12553 T12552 arg1Of manuscript,our
R9097 T12553 T12554 arg1Of manuscript,for
R9098 T12555 T12556 arg1Of TNF,","
R9099 T12556 T12558 arg1Of ",",","
R91 T161 T159 arg1Of strategies,novel
R910 T1641 T1640 arg1Of be,to
R9100 T12557 T12556 arg2Of IL-6,","
R9101 T12558 T12560 arg1Of ",",","
R9102 T12559 T12558 arg2Of KC,","
R9103 T12560 T12563 arg1Of ",",and
R9104 T12561 T12560 arg2Of MIP-2,","
R9105 T12563 T12554 arg2Of and,for
R9106 T12563 T12562 arg1Of and,","
R9107 T12564 T12563 arg2Of IFNβ,and
R9108 T12565 T12548 arg3Of ),(
R9109 T12568 T12566 arg2Of regulating,by
R911 T1643 T1641 arg2Of to,be
R9110 T12568 T12567 arg1Of regulating,negatively
R9111 T12569 T12570 arg1Of NF-κB,and
R9112 T12571 T12570 arg2Of IRF3,and
R9113 T12572 T12568 arg2Of activation,regulating
R9114 T12572 T12569 arg1Of activation,NF-κB
R9115 T12572 T12571 arg1Of activation,IRF3
R9116 T12572 T12573 arg1Of activation,","
R9117 T12572 T12574 arg1Of activation,which
R9118 T12572 T12575 arg1Of activation,are
R9119 T12578 T12575 arg2Of pathways,are
R912 T1643 T1642 arg1Of to,due
R9120 T12578 T12576 arg1Of pathways,the
R9121 T12578 T12577 arg1Of pathways,major
R9122 T12578 T12579 arg1Of pathways,controlling
R9123 T12581 T12579 arg2Of genes,controlling
R9124 T12581 T12580 arg1Of genes,these
R9125 T12584 T12585 arg1Of this,does
R9126 T12584 T12587 arg1Of this,exclude
R9127 T12587 T12582 arg1Of exclude,However
R9128 T12587 T12583 arg1Of exclude,","
R9129 T12587 T12585 arg2Of exclude,does
R913 T1648 T1643 arg2Of response,to
R9130 T12587 T12586 arg1Of exclude,not
R9131 T12590 T12587 arg2Of effect,exclude
R9132 T12590 T12588 arg1Of effect,an
R9133 T12590 T12589 arg1Of effect,additional
R9134 T12590 T12591 arg1Of effect,of
R9135 T12590 T12593 arg1Of effect,on
R9136 T12592 T12591 arg2Of A20,of
R9137 T12596 T12593 arg2Of pathways,on
R9138 T12596 T12594 arg1Of pathways,other
R9139 T12596 T12595 arg1Of pathways,signaling
R914 T1648 T1644 arg1Of response,an
R9140 T12596 T12597 arg1Of pathways,that
R9141 T12596 T12598 arg1Of pathways,may
R9142 T12596 T12599 arg1Of pathways,contribute
R9143 T12599 T12598 arg2Of contribute,may
R9144 T12599 T12600 arg1Of contribute,to
R9145 T12603 T12600 arg2Of expression,to
R9146 T12603 T12601 arg1Of expression,proinflammatory
R9147 T12603 T12602 arg1Of expression,gene
R9148 T12604 T12605 arg1Of A20,is
R9149 T12604 T12606 arg2Of A20,believed
R915 T1648 T1645 arg1Of response,excessive
R9150 T12604 T12608 arg1Of A20,exert
R9151 T12604 T12616 arg1Of A20,modulating
R9152 T12606 T12605 arg2Of believed,is
R9153 T12608 T12606 arg3Of exert,believed
R9154 T12608 T12607 arg1Of exert,to
R9155 T12608 T12615 arg1Of exert,by
R9156 T12608 T12624 arg1Of exert,[
R9157 T12610 T12611 arg1Of NF-κB,and
R9158 T12612 T12611 arg2Of IRF3,and
R9159 T12614 T12608 arg2Of functions,exert
R916 T1648 T1646 arg1Of response,host
R9160 T12614 T12609 arg1Of functions,its
R9161 T12614 T12610 arg1Of functions,NF-κB
R9162 T12614 T12612 arg1Of functions,IRF3
R9163 T12614 T12613 arg1Of functions,inhibitory
R9164 T12616 T12615 arg2Of modulating,by
R9165 T12619 T12616 arg2Of status,modulating
R9166 T12619 T12617 arg1Of status,the
R9167 T12619 T12618 arg1Of status,ubiquitination
R9168 T12619 T12620 arg1Of status,of
R9169 T12623 T12620 arg2Of proteins,of
R917 T1648 T1647 arg1Of response,inflammatory
R9170 T12623 T12621 arg1Of proteins,different
R9171 T12623 T12622 arg1Of proteins,signaling
R9172 T12625 T12624 arg2Of 80,[
R9173 T12626 T12624 arg3Of ],[
R9174 T12629 T12627 arg2Of context,In
R9175 T12629 T12628 arg1Of context,this
R9176 T12631 T12632 arg1Of it,was
R9177 T12631 T12634 arg2Of it,shown
R9178 T12634 T12627 arg1Of shown,In
R9179 T12634 T12630 arg1Of shown,","
R918 T1649 T1650 arg1Of Emergence,of
R9180 T12634 T12632 arg2Of shown,was
R9181 T12634 T12633 arg1Of shown,recently
R9182 T12636 T12637 arg1Of A20,cooperates
R9183 T12637 T12634 arg3Of cooperates,shown
R9184 T12637 T12635 arg1Of cooperates,that
R9185 T12637 T12638 arg1Of cooperates,with
R9186 T12637 T12645 arg1Of cooperates,to
R9187 T12637 T12651 arg1Of cooperates,","
R9188 T12637 T12654 modOf cooperates,affecting
R9189 T12641 T12639 arg1Of proteins,the
R919 T1649 T1659 arg1Of Emergence,underscores
R9190 T12641 T12640 arg1Of proteins,ubiquitin-binding
R9191 T12642 T12643 arg1Of TAX1BP1,and
R9192 T12643 T12638 arg2Of and,with
R9193 T12643 T12641 arg1Of and,proteins
R9194 T12644 T12643 arg2Of ABIN1,and
R9195 T12647 T12637 arg2Of disrupt,cooperates
R9196 T12647 T12646 arg1Of disrupt,to
R9197 T12650 T12647 arg2Of complex,disrupt
R9198 T12650 T12648 arg1Of complex,the
R9199 T12650 T12649 arg1Of complex,TRAF3-TBK1-IKKε
R92 T161 T160 arg1Of strategies,therapeutic
R920 T1652 T1650 arg2Of strains,of
R9200 T12654 T12652 arg1Of affecting,thereby
R9201 T12654 T12653 arg1Of affecting,negatively
R9202 T12654 T12670 arg1Of affecting,","
R9203 T12654 T12671 arg1Of affecting,[
R9204 T12655 T12654 arg2Of K63-polyubiquitination,affecting
R9205 T12655 T12656 arg1Of K63-polyubiquitination,of
R9206 T12657 T12658 arg1Of TBK1,and
R9207 T12658 T12661 arg1Of and,and
R9208 T12659 T12658 arg2Of IKKε,and
R9209 T12661 T12656 arg2Of and,of
R921 T1652 T1651 arg1Of strains,drug-resistant
R9210 T12661 T12660 arg1Of and,","
R9211 T12663 T12661 arg2Of ability,and
R9212 T12663 T12662 arg1Of ability,their
R9213 T12663 T12664 arg1Of ability,to
R9214 T12666 T12664 arg2Of IRF3,to
R9215 T12666 T12665 arg1Of IRF3,activity
R9216 T12666 T12667 arg1Of IRF3,[
R9217 T12668 T12667 arg2Of 81,[
R9218 T12669 T12667 arg3Of ],[
R9219 T12672 T12671 arg2Of 82,[
R922 T1652 T1653 arg1Of strains,of
R9220 T12673 T12671 arg3Of ],[
R9221 T12676 T12675 arg1Of mechanisms,similar
R9222 T12676 T12677 arg1Of mechanisms,are
R9223 T12676 T12678 arg2Of mechanisms,involved
R9224 T12678 T12674 arg1Of involved,Whether
R9225 T12678 T12677 arg2Of involved,are
R9226 T12678 T12679 arg1Of involved,in
R9227 T12678 T12687 arg1Of involved,is
R9228 T12678 T12689 arg1Of involved,unclear
R9229 T12681 T12679 arg2Of regulation,in
R923 T1655 T1653 arg2Of viruses,of
R9230 T12681 T12680 arg1Of regulation,the
R9231 T12681 T12682 arg1Of regulation,of
R9232 T12683 T12682 arg2Of RIG-I,of
R9233 T12686 T12679 arg3Of activation,in
R9234 T12686 T12684 arg2Of activation,induced
R9235 T12686 T12685 arg1Of activation,NF-κB
R9236 T12687 T12688 arg1Of is,still
R9237 T12689 T12687 arg2Of unclear,is
R9238 T12691 T12690 arg1Of far,So
R9239 T12692 T12693 arg1Of we,were
R924 T1655 T1654 arg1Of viruses,influenza
R9240 T12692 T12694 arg1Of we,unable
R9241 T12692 T12697 arg1Of we,detect
R9242 T12692 T12707 arg1Of we,preventing
R9243 T12693 T12691 arg1Of were,far
R9244 T12694 T12693 arg2Of unable,were
R9245 T12697 T12694 arg2Of detect,unable
R9246 T12697 T12695 arg1Of detect,to
R9247 T12697 T12696 arg1Of detect,clearly
R9248 T12697 T12706 arg1Of detect,","
R9249 T12697 T12707 modOf detect,preventing
R925 T1655 T1656 arg1Of viruses,with
R9250 T12698 T12697 arg2Of ubiquitination,detect
R9251 T12698 T12699 arg1Of ubiquitination,of
R9252 T12698 T12703 arg1Of ubiquitination,in
R9253 T12700 T12701 arg1Of TBK1,and
R9254 T12701 T12699 arg2Of and,of
R9255 T12702 T12701 arg2Of IKKε,and
R9256 T12705 T12703 arg2Of macrophages,in
R9257 T12705 T12704 arg1Of macrophages,primary
R9258 T12707 T12709 arg1Of preventing,from
R9259 T12708 T12707 arg2Of us,preventing
R926 T1658 T1656 arg2Of potential,with
R9260 T12710 T12709 arg2Of studying,from
R9261 T12712 T12710 arg2Of effect,studying
R9262 T12712 T12711 arg1Of effect,the
R9263 T12712 T12713 arg1Of effect,of
R9264 T12712 T12716 arg1Of effect,on
R9265 T12715 T12713 arg2Of deficiency,of
R9266 T12715 T12714 arg1Of deficiency,A20
R9267 T12719 T12716 arg2Of status,on
R9268 T12719 T12717 arg1Of status,their
R9269 T12719 T12718 arg1Of status,ubiquitination
R927 T1658 T1657 arg1Of potential,pandemic
R9270 T12720 T12721 arg1Of It,can
R9271 T12720 T12723 arg1Of It,be
R9272 T12720 T12724 arg2Of It,excluded
R9273 T12724 T12721 arg2Of excluded,can
R9274 T12724 T12722 arg1Of excluded,not
R9275 T12724 T12723 arg2Of excluded,be
R9276 T12724 T12725 arg1Of excluded,however
R9277 T12727 T12726 arg1Of A20,that
R9278 T12727 T12729 arg1Of A20,targets
R9279 T12729 T12725 arg2Of targets,however
R928 T1661 T1659 arg2Of importance,underscores
R9280 T12729 T12728 arg1Of targets,also
R9281 T12731 T12729 arg2Of substrates,targets
R9282 T12731 T12730 arg1Of substrates,other
R9283 T12731 T12732 arg1Of substrates,that
R9284 T12731 T12733 arg1Of substrates,mediate
R9285 T12733 T12738 arg1Of mediate,in
R9286 T12734 T12735 arg1Of NF-κB,and
R9287 T12735 T12733 arg2Of and,mediate
R9288 T12737 T12735 arg2Of activation,and
R9289 T12737 T12736 arg1Of activation,IRF3
R929 T1661 T1660 arg1Of importance,the
R9290 T12740 T12738 arg2Of cells,in
R9291 T12740 T12739 arg1Of cells,myeloid
R9292 T12742 T12741 arg1Of identification,The
R9293 T12742 T12743 arg1Of identification,of
R9294 T12742 T12746 arg1Of identification,will
R9295 T12742 T12747 arg1Of identification,be
R9296 T12745 T12743 arg2Of substrates,of
R9297 T12745 T12744 arg1Of substrates,these
R9298 T12747 T12746 arg2Of be,will
R9299 T12747 T12753 arg1Of be,in
R93 T163 T164 arg1Of we,used
R930 T1661 T1662 arg1Of importance,of
R9300 T12749 T12747 arg2Of topic,be
R9301 T12749 T12748 arg1Of topic,the
R9302 T12749 T12750 arg1Of topic,of
R9303 T12752 T12750 arg2Of investigations,of
R9304 T12752 T12751 arg1Of investigations,future
R9305 T12755 T12753 arg2Of laboratory,in
R9306 T12755 T12754 arg1Of laboratory,our
R9307 T12759 T12756 arg1Of enzymes,Multiple
R9308 T12759 T12757 arg1Of enzymes,other
R9309 T12759 T12758 arg1Of enzymes,deubiquitinating
R931 T1666 T1662 arg2Of strategies,of
R9310 T12759 T12760 arg1Of enzymes,(
R9311 T12759 T12763 arg1Of enzymes,","
R9312 T12759 T12765 arg1Of enzymes,as
R9313 T12761 T12760 arg2Of DUBs,(
R9314 T12762 T12760 arg3Of ),(
R9315 T12765 T12764 arg1Of as,such
R9316 T12766 T12767 arg1Of DUBA,[
R9317 T12766 T12770 arg1Of DUBA,","
R9318 T12768 T12767 arg2Of 28,[
R9319 T12769 T12767 arg3Of ],[
R932 T1666 T1663 arg1Of strategies,developing
R9320 T12770 T12775 arg1Of ",",","
R9321 T12770 T12776 arg1Of ",",[
R9322 T12770 T12779 arg1Of ",",","
R9323 T12770 T12785 arg1Of ",",and
R9324 T12771 T12770 arg2Of CYLD,","
R9325 T12771 T12772 arg1Of CYLD,[
R9326 T12773 T12772 arg2Of 29,[
R9327 T12774 T12772 arg3Of ],[
R9328 T12777 T12776 arg2Of 30,[
R9329 T12778 T12776 arg3Of ],[
R933 T1666 T1664 arg1Of strategies,novel
R9330 T12780 T12779 arg2Of OTUB1/2,","
R9331 T12780 T12781 arg1Of OTUB1/2,[
R9332 T12782 T12781 arg2Of 31,[
R9333 T12783 T12781 arg3Of ],[
R9334 T12785 T12765 arg2Of and,as
R9335 T12785 T12784 arg1Of and,","
R9336 T12786 T12785 arg2Of A20,and
R9337 T12786 T12787 arg1Of A20,[
R9338 T12786 T12794 modOf A20,have
R9339 T12788 T12787 arg2Of 49,[
R934 T1666 T1665 arg1Of strategies,antiviral
R9340 T12789 T12787 arg3Of ],[
R9341 T12790 T12791 arg1Of –,[
R9342 T12790 T12794 arg1Of –,have
R9343 T12790 T12795 arg1Of –,been
R9344 T12790 T12796 arg2Of –,shown
R9345 T12790 T12799 arg1Of –,regulate
R9346 T12792 T12791 arg2Of 52,[
R9347 T12793 T12791 arg3Of ],[
R9348 T12796 T12794 arg2Of shown,have
R9349 T12796 T12795 arg2Of shown,been
R935 T1669 T1667 arg2Of context,In
R9350 T12796 T12806 arg1Of shown,","
R9351 T12796 T12807 modOf shown,implicating
R9352 T12799 T12796 arg3Of regulate,shown
R9353 T12799 T12797 arg1Of regulate,to
R9354 T12799 T12798 arg1Of regulate,negatively
R9355 T12801 T12799 arg2Of signaling,regulate
R9356 T12801 T12800 arg1Of signaling,RIG-I
R9357 T12801 T12802 arg1Of signaling,to
R9358 T12803 T12804 arg1Of NF-κB,and
R9359 T12804 T12802 arg2Of and,to
R936 T1669 T1668 arg1Of context,this
R9360 T12805 T12804 arg2Of IRF-3,and
R9361 T12809 T12807 arg2Of redundancy,implicating
R9362 T12809 T12808 arg1Of redundancy,possible
R9363 T12812 T12815 arg1Of evidence,was
R9364 T12812 T12816 arg2Of evidence,limited
R9365 T12812 T12822 arg1Of evidence,was
R9366 T12812 T12823 arg2Of evidence,obtained
R9367 T12814 T12813 arg1Of far,so
R9368 T12816 T12815 arg2Of limited,was
R9369 T12816 T12817 arg1Of limited,to
R937 T1671 T1672 arg1Of understanding,of
R9370 T12816 T12821 arg1Of limited,and
R9371 T12819 T12818 arg1Of vitro,in
R9372 T12820 T12817 arg2Of data,to
R9373 T12820 T12819 arg1Of data,vitro
R9374 T12821 T12810 arg1Of and,However
R9375 T12821 T12811 arg1Of and,","
R9376 T12821 T12814 arg1Of and,far
R9377 T12823 T12821 arg2Of obtained,and
R9378 T12823 T12822 arg2Of obtained,was
R9379 T12823 T12824 arg1Of obtained,under
R938 T1671 T1680 arg1Of understanding,is
R9380 T12826 T12824 arg2Of conditions,under
R9381 T12826 T12825 arg1Of conditions,non-physiological
R9382 T12830 T12827 arg1Of phenotype,The
R9383 T12830 T12828 arg1Of phenotype,clear
R9384 T12830 T12829 arg1Of phenotype,protective
R9385 T12830 T12831 arg1Of phenotype,of
R9386 T12830 T12834 arg1Of phenotype,that
R9387 T12830 T12837 arg2Of phenotype,describe
R9388 T12830 T12838 arg1Of phenotype,indicates
R9389 T12833 T12831 arg2Of mice,of
R939 T1671 T1681 arg1Of understanding,critical
R9390 T12833 T12832 arg1Of mice,A20myel-KO
R9391 T12835 T12837 arg1Of we,describe
R9392 T12837 T12836 arg1Of describe,here
R9393 T12841 T12840 arg1Of expression,A20
R9394 T12841 T12842 arg1Of expression,in
R9395 T12841 T12845 arg1Of expression,is
R9396 T12844 T12842 arg2Of cells,in
R9397 T12844 T12843 arg1Of cells,myeloid
R9398 T12845 T12839 arg1Of is,that
R9399 T12845 T12853 arg1Of is,in
R94 T163 T172 arg1Of we,examine
R940 T1674 T1672 arg2Of mechanisms,of
R9400 T12845 T12858 arg1Of is,and
R9401 T12848 T12845 arg2Of gatekeeper,is
R9402 T12848 T12846 arg1Of gatekeeper,a
R9403 T12848 T12847 arg1Of gatekeeper,central
R9404 T12848 T12849 arg1Of gatekeeper,of
R9405 T12852 T12849 arg2Of signaling,of
R9406 T12852 T12850 arg1Of signaling,RIG-I
R9407 T12852 T12851 arg2Of signaling,induced
R9408 T12853 T12855 arg1Of in,to
R9409 T12854 T12853 arg2Of response,in
R941 T1674 T1673 arg1Of mechanisms,the
R9410 T12857 T12853 arg3Of infection,in
R9411 T12857 T12856 arg1Of infection,IAV
R9412 T12858 T12838 arg2Of and,indicates
R9413 T12859 T12858 arg2Of that,and
R9414 T12861 T12860 arg1Of DUBs,other
R9415 T12861 T12862 arg1Of DUBs,can
R9416 T12861 T12864 arg1Of DUBs,substitute
R9417 T12864 T12859 arg2Of substitute,that
R9418 T12864 T12862 arg2Of substitute,can
R9419 T12864 T12863 arg1Of substitute,not
R942 T1674 T1675 arg1Of mechanisms,that
R9420 T12864 T12865 arg1Of substitute,for
R9421 T12864 T12868 arg1Of substitute,under
R9422 T12867 T12865 arg2Of deficiency,for
R9423 T12867 T12866 arg1Of deficiency,A20
R9424 T12870 T12868 arg2Of conditions,under
R9425 T12870 T12869 arg1Of conditions,physiological
R9426 T12872 T12873 arg1Of A20,has
R9427 T12873 T12871 arg1Of has,If
R9428 T12873 T12897 arg1Of has,remains
R9429 T12873 T12899 arg1Of has,be
R943 T1674 T1676 arg1Of mechanisms,regulate
R9430 T12873 T12900 arg2Of has,investigated
R9431 T12877 T12873 arg2Of role,has
R9432 T12877 T12874 arg1Of role,a
R9433 T12877 T12875 arg1Of role,similar
R9434 T12877 T12876 arg1Of role,non-redundant
R9435 T12877 T12878 arg1Of role,in
R9436 T12877 T12890 arg1Of role,","
R9437 T12877 T12892 arg1Of role,as
R9438 T12881 T12878 arg2Of types,in
R9439 T12881 T12879 arg1Of types,other
R944 T1679 T1676 arg2Of responses,regulate
R9440 T12881 T12880 arg1Of types,cell
R9441 T12881 T12882 arg1Of types,that
R9442 T12881 T12883 arg1Of types,are
R9443 T12881 T12884 arg2Of types,implicated
R9444 T12884 T12883 arg2Of implicated,are
R9445 T12884 T12885 arg1Of implicated,in
R9446 T12887 T12885 arg2Of response,in
R9447 T12887 T12886 arg1Of response,the
R9448 T12887 T12888 arg1Of response,to
R9449 T12889 T12888 arg2Of IAV,to
R945 T1679 T1677 arg1Of responses,IAV-induced
R9450 T12892 T12891 arg1Of as,such
R9451 T12895 T12892 arg2Of cells,as
R9452 T12895 T12893 arg1Of cells,lung
R9453 T12895 T12894 arg1Of cells,epithelial
R9454 T12897 T12896 arg1Of remains,","
R9455 T12900 T12897 arg2Of investigated,remains
R9456 T12900 T12898 arg1Of investigated,to
R9457 T12900 T12899 arg2Of investigated,be
R9458 T12901 T12902 arg1Of Understanding,and
R9459 T12902 T12911 arg2Of and,is
R946 T1679 T1678 arg1Of responses,immune
R9460 T12903 T12902 arg2Of controlling,and
R9461 T12905 T12901 arg2Of activation,Understanding
R9462 T12905 T12903 arg2Of activation,controlling
R9463 T12905 T12904 arg1Of activation,the
R9464 T12905 T12906 arg1Of activation,of
R9465 T12910 T12906 arg2Of responses,of
R9466 T12910 T12907 arg1Of responses,innate
R9467 T12910 T12908 arg1Of responses,antiviral
R9468 T12910 T12909 arg1Of responses,immune
R9469 T12914 T12901 arg1Of step,Understanding
R947 T1680 T1667 arg1Of is,In
R9470 T12914 T12903 arg1Of step,controlling
R9471 T12914 T12911 arg1Of step,is
R9472 T12914 T12912 arg1Of step,an
R9473 T12914 T12913 arg1Of step,important
R9474 T12914 T12915 arg1Of step,toward
R9475 T12917 T12915 arg2Of therapies,toward
R9476 T12917 T12916 arg1Of therapies,novel
R9477 T12920 T12918 arg1Of fifth,About
R9478 T12920 T12919 arg1Of fifth,a
R9479 T12920 T12921 arg1Of fifth,of
R948 T1680 T1670 arg1Of is,","
R9480 T12920 T12925 arg1Of fifth,is
R9481 T12920 T12926 arg2Of fifth,infected
R9482 T12922 T12923 arg2Of world,'s
R9483 T12924 T12921 arg2Of population,of
R9484 T12924 T12923 arg1Of population,'s
R9485 T12926 T12925 arg2Of infected,is
R9486 T12926 T12929 arg1Of infected,annually
R9487 T12926 T12930 arg1Of infected,","
R9488 T12926 T12931 modOf infected,leading
R9489 T12926 T12937 arg1Of infected,","
R949 T1681 T1680 arg2Of critical,is
R9490 T12926 T12939 arg1Of infected,in
R9491 T12928 T12926 arg1Of IAV,infected
R9492 T12928 T12927 arg2Of IAV,by
R9493 T12931 T12932 arg1Of leading,to
R9494 T12934 T12935 arg1Of morbidity,and
R9495 T12935 T12932 arg2Of and,to
R9496 T12935 T12933 arg1Of and,high
R9497 T12936 T12935 arg2Of mortality,and
R9498 T12939 T12938 arg1Of in,particularly
R9499 T12940 T12939 arg2Of infants,in
R95 T164 T162 arg1Of used,Here
R950 T1683 T1682 arg1Of infection,IAV
R9500 T12940 T12941 arg1Of infants,","
R9501 T12943 T12942 arg1Of elderly,the
R9502 T12943 T12944 arg1Of elderly,and
R9503 T12944 T12941 arg2Of and,","
R9504 T12946 T12944 arg2Of immunocompromised,and
R9505 T12946 T12945 arg1Of immunocompromised,the
R9506 T12950 T12947 arg1Of rate,The
R9507 T12950 T12948 arg1Of rate,high
R9508 T12950 T12949 arg1Of rate,mutation
R9509 T12950 T12951 arg1Of rate,of
R951 T1683 T1684 arg1Of infection,leads
R9510 T12950 T12953 arg1Of rate,turns
R9511 T12952 T12951 arg2Of IAV,of
R9512 T12955 T12953 arg2Of attempts,turns
R9513 T12955 T12954 arg1Of attempts,all
R9514 T12955 T12956 arg1Of attempts,of
R9515 T12955 T12961 arg1Of attempts,into
R9516 T12957 T12958 arg1Of vaccine,and
R9517 T12958 T12956 arg2Of and,of
R9518 T12960 T12958 arg2Of design,and
R9519 T12960 T12959 arg1Of design,antiviral
R952 T1684 T1685 arg1Of leads,to
R9520 T12962 T12964 arg1Of a,ending
R9521 T12964 T12961 arg2Of ending,into
R9522 T12964 T12962 arg1Of ending,a
R9523 T12964 T12963 arg1Of ending,never
R9524 T12965 T12964 arg2Of battle,ending
R9525 T12968 T12966 arg2Of years,In
R9526 T12968 T12967 arg1Of years,recent
R9527 T12971 T12970 arg1Of interference,RNA
R9528 T12971 T12972 arg1Of interference,","
R9529 T12971 T12973 arg2Of interference,triggered
R953 T1687 T1685 arg2Of exposure,to
R9530 T12971 T12983 arg1Of interference,has
R9531 T12971 T12985 arg1Of interference,evolved
R9532 T12978 T12973 arg1Of RNA,triggered
R9533 T12978 T12974 arg2Of RNA,by
R9534 T12978 T12975 arg1Of RNA,synthetic
R9535 T12978 T12976 arg1Of RNA,short
R9536 T12978 T12977 arg1Of RNA,interfering
R9537 T12978 T12979 arg1Of RNA,(
R9538 T12980 T12979 arg2Of siRNA,(
R9539 T12981 T12979 arg3Of ),(
R954 T1687 T1686 arg1Of exposure,the
R9540 T12985 T12966 arg1Of evolved,In
R9541 T12985 T12969 arg1Of evolved,","
R9542 T12985 T12982 arg1Of evolved,","
R9543 T12985 T12983 arg2Of evolved,has
R9544 T12985 T12984 arg1Of evolved,rapidly
R9545 T12985 T12986 arg1Of evolved,as
R9546 T12990 T12986 arg2Of regimen,as
R9547 T12990 T12987 arg1Of regimen,a
R9548 T12990 T12988 arg1Of regimen,potent
R9549 T12990 T12989 arg1Of regimen,antiviral
R955 T1687 T1688 arg1Of exposure,in
R9550 T12992 T12991 arg1Of designed,Properly
R9551 T12993 T12992 arg1Of siRNAs,designed
R9552 T12993 T12994 arg1Of siRNAs,have
R9553 T12993 T12995 arg1Of siRNAs,been
R9554 T12993 T12996 arg2Of siRNAs,shown
R9555 T12993 T12998 arg1Of siRNAs,function
R9556 T12996 T12994 arg2Of shown,have
R9557 T12996 T12995 arg2Of shown,been
R9558 T12998 T12996 arg3Of function,shown
R9559 T12998 T12997 arg1Of function,to
R956 T1687 T1700 arg1Of exposure,","
R9560 T12998 T12999 arg1Of function,as
R9561 T13001 T12999 arg2Of inhibitors,as
R9562 T13001 T13000 arg1Of inhibitors,potent
R9563 T13001 T13002 arg1Of inhibitors,of
R9564 T13005 T13002 arg2Of replication,of
R9565 T13005 T13003 arg1Of replication,influenza
R9566 T13005 T13004 arg1Of replication,virus
R9567 T13007 T13008 arg1Of specificity,and
R9568 T13008 T13011 arg1Of and,remain
R9569 T13010 T13008 arg2Of delivery,and
R957 T1691 T1688 arg2Of cell,in
R9570 T13010 T13009 arg1Of delivery,tissue
R9571 T13011 T13006 arg2Of remain,Although
R9572 T13011 T13014 arg1Of remain,in
R9573 T13011 T13020 arg1Of remain,in
R9574 T13013 T13011 arg2Of bottlenecks,remain
R9575 T13013 T13012 arg1Of bottlenecks,major
R9576 T13017 T13014 arg2Of applications,in
R9577 T13017 T13015 arg1Of applications,the
R9578 T13017 T13016 arg1Of applications,clinical
R9579 T13017 T13018 arg1Of applications,of
R958 T1691 T1689 arg1Of cell,the
R9580 T13019 T13018 arg2Of RNAi,of
R9581 T13021 T13020 arg2Of general,in
R9582 T13024 T13023 arg1Of application,intranasal
R9583 T13024 T13025 arg1Of application,of
R9584 T13024 T13027 arg1Of application,against
R9585 T13024 T13034 arg2Of application,limited
R9586 T13024 T13039 arg1Of application,has
R9587 T13024 T13040 arg1Of application,experienced
R9588 T13026 T13025 arg2Of siRNA,of
R9589 T13029 T13027 arg2Of viruses,against
R959 T1691 T1690 arg1Of cell,host
R9590 T13029 T13028 arg1Of viruses,respiratory
R9591 T13029 T13030 arg1Of viruses,including
R9592 T13030 T13032 arg1Of including,but
R9593 T13032 T13031 arg1Of but,","
R9594 T13032 T13033 arg1Of but,not
R9595 T13034 T13035 arg1Of limited,to
R9596 T13037 T13035 arg2Of virus,to
R9597 T13037 T13036 arg1Of virus,influenza
R9598 T13040 T13006 arg1Of experienced,Although
R9599 T13040 T13022 arg1Of experienced,","
R96 T164 T171 modOf used,to
R960 T1691 T1692 arg1Of cell,of
R9600 T13040 T13038 arg1Of experienced,","
R9601 T13040 T13039 arg2Of experienced,has
R9602 T13042 T13041 arg1Of success,significant
R9603 T13042 T13043 arg1Of success,and
R9604 T13043 T13040 arg2Of and,experienced
R9605 T13044 T13043 arg2Of optimism,and
R9606 T13044 T13045 arg1Of optimism,[
R9607 T13046 T13045 arg2Of 83,[
R9608 T13047 T13045 arg3Of ],[
R9609 T13049 T13048 arg1Of results,Our
R961 T1695 T1693 arg1Of RNA,single-stranded
R9610 T13049 T13050 arg1Of results,suggest
R9611 T13053 T13052 arg1Of only,not
R9612 T13054 T13053 arg1Of siRNA,only
R9613 T13054 T13055 arg1Of siRNA,targeting
R9614 T13054 T13060 arg1Of siRNA,boosting
R9615 T13054 T13072 arg1Of siRNA,might
R9616 T13054 T13073 arg1Of siRNA,be
R9617 T13055 T13059 arg1Of targeting,but
R9618 T13057 T13055 arg2Of components,targeting
R9619 T13057 T13056 arg1Of components,IAV
R962 T1695 T1694 arg1Of RNA,genomic
R9620 T13059 T13058 arg1Of but,","
R9621 T13060 T13059 arg2Of boosting,but
R9622 T13064 T13060 arg2Of response,boosting
R9623 T13064 T13061 arg1Of response,the
R9624 T13064 T13062 arg1Of response,antiviral
R9625 T13064 T13063 arg1Of response,immune
R9626 T13064 T13065 arg1Of response,by
R9627 T13067 T13065 arg2Of administration,by
R9628 T13067 T13066 arg1Of administration,intranasal
R9629 T13067 T13068 arg1Of administration,of
R963 T1695 T1696 arg1Of RNA,and
R9630 T13067 T13070 arg1Of administration,against
R9631 T13069 T13068 arg2Of siRNA,of
R9632 T13071 T13070 arg2Of A20,against
R9633 T13073 T13050 arg2Of be,suggest
R9634 T13073 T13051 arg1Of be,that
R9635 T13073 T13072 arg2Of be,might
R9636 T13076 T13075 arg1Of therapeutic,valid
R9637 T13077 T13073 arg2Of approach,be
R9638 T13077 T13074 arg1Of approach,a
R9639 T13077 T13076 arg1Of approach,therapeutic
R964 T1696 T1692 arg2Of and,of
R9640 T13079 T13078 arg1Of small,Also
R9641 T13081 T13079 arg1Of inhibitors,small
R9642 T13081 T13080 arg1Of inhibitors,compound
R9643 T13081 T13082 arg1Of inhibitors,of
R9644 T13081 T13084 arg1Of inhibitors,might
R9645 T13081 T13085 arg1Of inhibitors,be
R9646 T13083 T13082 arg2Of A20,of
R9647 T13085 T13084 arg2Of be,might
R9648 T13088 T13085 arg2Of alternative,be
R9649 T13088 T13086 arg1Of alternative,an
R965 T1699 T1696 arg2Of RNA,and
R9650 T13088 T13087 arg1Of alternative,interesting
R9651 T13092 T13091 arg1Of targeting,similar
R9652 T13092 T13093 arg1Of targeting,of
R9653 T13092 T13095 arg1Of targeting,might
R9654 T13092 T13096 arg1Of targeting,be
R9655 T13092 T13097 arg1Of targeting,of
R9656 T13094 T13093 arg2Of A20,of
R9657 T13096 T13089 arg1Of be,Finally
R9658 T13096 T13090 arg1Of be,","
R9659 T13096 T13095 arg2Of be,might
R966 T1699 T1697 arg1Of RNA,double
R9660 T13097 T13096 arg2Of of,be
R9661 T13098 T13097 arg2Of interest,of
R9662 T13098 T13099 arg1Of interest,in
R9663 T13101 T13099 arg2Of battle,in
R9664 T13101 T13100 arg1Of battle,the
R9665 T13101 T13102 arg1Of battle,against
R9666 T13105 T13102 arg2Of infections,against
R9667 T13105 T13103 arg1Of infections,other
R9668 T13105 T13104 arg1Of infections,viral
R9669 T13105 T13106 arg1Of infections,including
R967 T1699 T1698 arg1Of RNA,stranded
R9670 T13107 T13108 arg1Of RSV,and
R9671 T13108 T13106 arg2Of and,including
R9672 T13110 T13108 arg2Of coronavirus,and
R9673 T13110 T13109 arg1Of coronavirus,SARS
R968 T1702 T1700 arg2Of latter,","
R969 T1702 T1701 arg1Of latter,the
R97 T170 T164 arg2Of mice,used
R970 T1703 T1684 arg2Of being,leads
R971 T1705 T1703 arg2Of intermediate,being
R972 T1705 T1704 arg1Of intermediate,an
R973 T1705 T1706 arg1Of intermediate,of
R974 T1708 T1706 arg2Of replication,of
R975 T1708 T1707 arg1Of replication,viral
R976 T1709 T1710 arg1Of TLR3,and
R977 T1710 T1712 arg1Of and,have
R978 T1710 T1713 arg1Of and,been
R979 T1710 T1714 arg2Of and,implicated
R98 T170 T165 arg1Of mice,myeloid
R980 T1711 T1710 arg2Of RIG-I,and
R981 T1714 T1712 arg2Of implicated,have
R982 T1714 T1713 arg2Of implicated,been
R983 T1714 T1715 arg1Of implicated,as
R984 T1714 T1720 arg1Of implicated,[
R985 T1716 T1715 arg2Of sensors,as
R986 T1716 T1717 arg1Of sensors,of
R987 T1719 T1717 arg2Of infection,of
R988 T1719 T1718 arg1Of infection,IAV
R989 T1721 T1720 arg2Of 10,[
R99 T170 T166 arg1Of mice,cell
R990 T1722 T1720 arg3Of ],[
R991 T1723 T1714 arg3Of –,implicated
R992 T1723 T1724 arg1Of –,[
R993 T1725 T1724 arg2Of 12,[
R994 T1726 T1724 arg3Of ],[
R995 T1728 T1727 arg1Of receptors,Both
R996 T1728 T1729 arg1Of receptors,contribute
R997 T1729 T1730 arg1Of contribute,to
R998 T1729 T1737 arg1Of contribute,but
R999 T1733 T1730 arg2Of response,to