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PMC:3279418 / 165-1757 JSONTXT 16 Projects

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Id Subject Object Predicate Lexical cue
T417 0-11 JJ denotes Spontaneous
T418 12-21 NN denotes mutations
T419 22-24 IN denotes of
T420 25-28 DT denotes the
T421 29-36 NNP denotes Sharpin
T422 37-38 -LRB- denotes (
T423 38-54 JJ denotes SHANK-associated
T424 55-57 NN denotes RH
T425 58-76 JJ denotes domain-interacting
T426 77-84 NN denotes protein
T427 84-85 -COMMA- denotes ,
T428 86-91 JJ denotes other
T429 92-99 NN denotes aliases
T430 99-100 -COLON- denotes :
T431 101-107 NN denotes Rbckl1
T432 107-108 -COMMA- denotes ,
T433 109-114 NN denotes Sipl1
T434 114-115 -RRB- denotes )
T435 116-120 NN denotes gene
T436 121-123 IN denotes in
T437 124-128 NN denotes mice
T438 129-135 VB denotes result
T439 136-138 IN denotes in
T440 139-147 JJ denotes systemic
T441 148-160 NN denotes inflammation
T442 161-165 WDT denotes that
T443 166-168 VB denotes is
T444 169-182 VB denotes characterized
T445 183-185 IN denotes by
T446 186-193 JJ denotes chronic
T447 194-207 JJ denotes proliferative
T448 208-218 NN denotes dermatitis
T449 219-222 CC denotes and
T450 223-235 VB denotes dysregulated
T451 236-245 NN denotes secretion
T452 246-248 IN denotes of
T453 249-250 NN denotes T
T454 251-258 NN denotes helper1
T455 259-260 -LRB- denotes (
T456 260-263 NN denotes Th1
T457 263-264 -RRB- denotes )
T458 265-268 CC denotes and
T459 269-272 NN denotes Th2
T460 273-282 NN denotes cytokines
T461 284-287 DT denotes The
T462 288-296 JJ denotes cellular
T463 297-300 CC denotes and
T464 301-310 JJ denotes molecular
T465 311-321 NN denotes mechanisms
T466 322-332 VB denotes underlying
T467 333-337 DT denotes this
T468 338-350 JJ denotes inflammatory
T469 351-360 NN denotes phenotype
T470 361-367 VB denotes remain
T471 368-375 JJ denotes elusive
T472 377-386 JJ denotes Dendritic
T473 387-392 NN denotes cells
T474 393-396 MD denotes may
T475 397-407 VB denotes contribute
T476 408-410 TO denotes to
T477 411-414 DT denotes the
T478 415-425 NN denotes initiation
T479 426-429 CC denotes and
T480 430-441 NN denotes progression
T481 442-444 IN denotes of
T482 445-448 DT denotes the
T483 449-458 NN denotes phenotype
T484 459-461 IN denotes of
T485 462-479 JJ denotes SHARPIN-deficient
T486 480-484 NN denotes mice
T487 485-492 IN denotes because
T488 493-495 IN denotes of
T489 496-501 PRP-DOLLAR- denotes their
T490 502-509 JJ denotes pivotal
T491 510-514 NN denotes role
T492 515-517 IN denotes in
T493 518-524 JJ denotes innate
T494 525-528 CC denotes and
T495 529-537 JJ denotes adaptive
T496 538-546 NN denotes immunity
T497 548-552 RB denotes Here
T498 553-555 PRP denotes we
T499 556-560 VB denotes show
T500 561-563 IN denotes by
T501 564-568 NN denotes flow
T502 569-578 NN denotes cytometry
T503 579-583 IN denotes that
T504 584-592 NN denotes SHARPIN-
T505 593-603 NN denotes deficiency
T506 604-607 VB denotes did
T507 608-611 RB denotes not
T508 612-617 VB denotes alter
T509 618-621 DT denotes the
T510 622-634 NN denotes distribution
T511 635-637 IN denotes of
T512 638-647 JJ denotes different
T513 648-650 NN denotes DC
T514 651-659 NN denotes subtypes
T515 660-662 IN denotes in
T516 663-666 DT denotes the
T517 667-673 NN denotes spleen
T518 675-677 IN denotes In
T519 678-686 NN denotes response
T520 687-689 TO denotes to
T521 690-699 JJ denotes TOLL-like
T522 700-708 NN denotes receptor
T523 709-710 -LRB- denotes (
T524 710-713 NN denotes TLR
T525 713-714 -RRB- denotes )
T526 715-723 NN denotes agonists
T527 724-727 NN denotes LPS
T528 728-731 CC denotes and
T529 732-736 NN denotes poly
T530 737-738 NN denotes I
T531 738-739 -COLON- denotes :
T532 739-740 NN denotes C
T533 740-741 -COMMA- denotes ,
T534 742-750 VB denotes cultured
T535 751-755 NN denotes bone
T536 756-770 JJ denotes marrow-derived
T537 771-780 JJ denotes dendritic
T538 781-786 NN denotes cells
T539 787-788 -LRB- denotes (
T540 788-792 NN denotes BMDC
T541 792-793 -RRB- denotes )
T542 794-798 IN denotes from
T543 799-801 NN denotes WT
T544 802-805 CC denotes and
T545 806-812 JJ denotes mutant
T546 813-817 NN denotes mice
T547 818-827 VB denotes exhibited
T548 828-835 JJ denotes similar
T549 836-845 NN denotes increases
T550 846-848 IN denotes in
T551 849-859 NN denotes expression
T552 860-862 IN denotes of
T553 863-877 JJ denotes co-stimulatory
T554 878-887 NN denotes molecules
T555 888-892 NN denotes CD40
T556 892-893 -COMMA- denotes ,
T557 894-898 NN denotes CD80
T558 898-899 -COMMA- denotes ,
T559 900-903 CC denotes and
T560 904-908 NN denotes CD86
T561 910-917 RB denotes However
T562 917-918 -COMMA- denotes ,
T563 919-929 VB denotes stimulated
T564 930-947 JJ denotes SHARPIN-deficient
T565 948-952 NN denotes BMDC
T566 953-956 VB denotes had
T567 957-964 VB denotes reduced
T568 965-978 NN denotes transcription
T569 979-982 CC denotes and
T570 983-992 NN denotes secretion
T571 993-995 IN denotes of
T572 996-1012 JJ denotes pro-inflammatory
T573 1013-1022 NN denotes mediators
T574 1023-1026 NN denotes IL6
T575 1026-1027 -COMMA- denotes ,
T576 1028-1035 NN denotes IL12P70
T577 1035-1036 -COMMA- denotes ,
T578 1037-1042 NN denotes GMCSF
T579 1042-1043 -COMMA- denotes ,
T580 1044-1047 CC denotes and
T581 1048-1054 JJ denotes nitric
T582 1055-1060 NN denotes oxide
T583 1062-1068 JJ denotes Mutant
T584 1069-1073 NN denotes BMDC
T585 1074-1077 VB denotes had
T586 1078-1087 JJ denotes defective
T587 1088-1098 NN denotes activation
T588 1099-1101 IN denotes of
T589 1102-1107 NN denotes NF-κB
T590 1108-1117 NN denotes signaling
T591 1117-1118 -COMMA- denotes ,
T592 1119-1126 IN denotes whereas
T593 1127-1130 DT denotes the
T594 1131-1138 NN denotes MAPK1/3
T595 1139-1140 -LRB- denotes (
T596 1140-1146 NN denotes ERK1/2
T597 1146-1147 -RRB- denotes )
T598 1148-1151 CC denotes and
T599 1152-1167 NN denotes MAPK11/12/13/14
T600 1168-1169 -LRB- denotes (
T601 1169-1172 NN denotes p38
T602 1173-1176 NN denotes MAP
T603 1177-1183 NN denotes kinase
T604 1184-1192 NN denotes isoforms
T605 1192-1193 -RRB- denotes )
T606 1194-1197 CC denotes and
T607 1198-1202 NN denotes TBK1
T608 1203-1212 NN denotes signaling
T609 1213-1221 NN denotes pathways
T610 1222-1226 VB denotes were
T611 1227-1233 JJ denotes intact
T612 1235-1236 DT denotes A
T613 1237-1242 JJ denotes mixed
T614 1243-1253 NN denotes lymphocyte
T615 1254-1262 NN denotes reaction
T616 1263-1269 VB denotes showed
T617 1270-1274 IN denotes that
T618 1275-1281 JJ denotes mutant
T619 1282-1286 NN denotes BMDC
T620 1287-1291 RB denotes only
T621 1292-1299 VB denotes induced
T622 1300-1301 DT denotes a
T623 1302-1306 JJ denotes weak
T624 1307-1310 NN denotes Th1
T625 1311-1317 JJ denotes immune
T626 1318-1326 NN denotes response
T627 1327-1330 CC denotes but
T628 1331-1341 VB denotes stimulated
T629 1342-1351 VB denotes increased
T630 1352-1355 NN denotes Th2
T631 1356-1364 NN denotes cytokine
T632 1365-1375 NN denotes production
T633 1376-1380 IN denotes from
T634 1381-1391 JJ denotes allogeneic
T635 1392-1397 NN denotes naïve
T636 1398-1402 JJ denotes CD4+
T637 1403-1404 NN denotes T
T638 1405-1410 NN denotes cells
T639 1412-1414 IN denotes In
T640 1415-1425 NN denotes conclusion
T641 1425-1426 -COMMA- denotes ,
T642 1427-1431 NN denotes loss
T643 1432-1434 IN denotes of
T644 1435-1442 NN denotes Sharpin
T645 1443-1445 IN denotes in
T646 1446-1450 NN denotes mice
T647 1451-1464 RB denotes significantly
T648 1465-1472 VB denotes affects
T649 1473-1476 DT denotes the
T650 1477-1483 JJ denotes immune
T651 1484-1492 NN denotes function
T652 1493-1495 IN denotes of
T653 1496-1498 NN denotes DC
T654 1499-1502 CC denotes and
T655 1503-1507 DT denotes this
T656 1508-1511 MD denotes may
T657 1512-1521 RB denotes partially
T658 1522-1529 VB denotes account
T659 1530-1533 IN denotes for
T660 1534-1537 DT denotes the
T661 1538-1546 JJ denotes systemic
T662 1547-1559 NN denotes inflammation
T663 1560-1563 CC denotes and
T664 1564-1574 JJ denotes Th2-biased
T665 1575-1581 JJ denotes immune
T666 1582-1590 NN denotes response
R333 T418 T417 arg1Of mutations,Spontaneous
R334 T418 T419 arg1Of mutations,of
R335 T426 T419 arg2Of protein,of
R336 T426 T420 arg1Of protein,the
R337 T426 T421 arg1Of protein,Sharpin
R338 T426 T422 arg1Of protein,(
R339 T426 T423 arg1Of protein,SHANK-associated
R340 T426 T424 arg1Of protein,RH
R341 T426 T425 arg1Of protein,domain-interacting
R342 T426 T427 arg1Of protein,","
R343 T429 T427 arg2Of aliases,","
R344 T429 T428 arg1Of aliases,other
R345 T429 T430 arg1Of aliases,:
R346 T431 T432 arg1Of Rbckl1,","
R347 T431 T438 arg1Of Rbckl1,result
R348 T433 T432 arg2Of Sipl1,","
R349 T433 T434 arg1Of Sipl1,)
R350 T433 T435 arg1Of Sipl1,gene
R351 T433 T436 arg1Of Sipl1,in
R352 T437 T436 arg2Of mice,in
R353 T438 T439 arg1Of result,in
R354 T441 T439 arg2Of inflammation,in
R355 T441 T440 arg1Of inflammation,systemic
R356 T441 T442 arg1Of inflammation,that
R357 T441 T443 arg1Of inflammation,is
R358 T441 T444 arg2Of inflammation,characterized
R359 T444 T443 arg2Of characterized,is
R360 T448 T446 arg1Of dermatitis,chronic
R361 T448 T447 arg1Of dermatitis,proliferative
R362 T448 T449 arg1Of dermatitis,and
R363 T449 T444 arg1Of and,characterized
R364 T449 T445 arg2Of and,by
R365 T451 T449 arg2Of secretion,and
R366 T451 T450 arg2Of secretion,dysregulated
R367 T451 T452 arg1Of secretion,of
R368 T454 T453 arg1Of helper1,T
R369 T454 T455 arg1Of helper1,(
R370 T454 T458 arg1Of helper1,and
R371 T456 T455 arg2Of Th1,(
R372 T457 T455 arg3Of ),(
R373 T459 T458 arg2Of Th2,and
R374 T460 T452 arg2Of cytokines,of
R375 T460 T454 arg1Of cytokines,helper1
R376 T460 T459 arg1Of cytokines,Th2
R377 T462 T463 arg1Of cellular,and
R378 T464 T463 arg2Of molecular,and
R379 T465 T461 arg1Of mechanisms,The
R380 T465 T462 arg1Of mechanisms,cellular
R381 T465 T464 arg1Of mechanisms,molecular
R382 T465 T466 arg1Of mechanisms,underlying
R383 T465 T470 arg1Of mechanisms,remain
R384 T465 T471 arg1Of mechanisms,elusive
R385 T469 T466 arg2Of phenotype,underlying
R386 T469 T467 arg1Of phenotype,this
R387 T469 T468 arg1Of phenotype,inflammatory
R388 T471 T470 arg2Of elusive,remain
R389 T473 T472 arg1Of cells,Dendritic
R390 T473 T474 arg1Of cells,may
R391 T473 T475 arg1Of cells,contribute
R392 T475 T474 arg2Of contribute,may
R393 T475 T476 arg1Of contribute,to
R394 T475 T487 arg1Of contribute,because
R395 T478 T479 arg1Of initiation,and
R396 T479 T476 arg2Of and,to
R397 T479 T477 arg1Of and,the
R398 T479 T481 arg1Of and,of
R399 T480 T479 arg2Of progression,and
R400 T483 T481 arg2Of phenotype,of
R401 T483 T482 arg1Of phenotype,the
R402 T483 T484 arg1Of phenotype,of
R403 T486 T484 arg2Of mice,of
R404 T486 T485 arg1Of mice,SHARPIN-deficient
R405 T487 T488 arg1Of because,of
R406 T491 T487 arg2Of role,because
R407 T491 T489 arg1Of role,their
R408 T491 T490 arg1Of role,pivotal
R409 T491 T492 arg1Of role,in
R410 T493 T494 arg1Of innate,and
R411 T495 T494 arg2Of adaptive,and
R412 T496 T492 arg2Of immunity,in
R413 T496 T493 arg1Of immunity,innate
R414 T496 T495 arg1Of immunity,adaptive
R415 T498 T499 arg1Of we,show
R416 T499 T497 arg1Of show,Here
R417 T499 T500 arg1Of show,by
R418 T502 T500 arg2Of cytometry,by
R419 T502 T501 arg1Of cytometry,flow
R420 T505 T504 arg1Of deficiency,SHARPIN-
R421 T505 T506 arg1Of deficiency,did
R422 T505 T508 arg1Of deficiency,alter
R423 T508 T499 arg2Of alter,show
R424 T508 T503 arg1Of alter,that
R425 T508 T506 arg2Of alter,did
R426 T508 T507 arg1Of alter,not
R427 T510 T508 arg2Of distribution,alter
R428 T510 T509 arg1Of distribution,the
R429 T510 T511 arg1Of distribution,of
R430 T514 T511 arg2Of subtypes,of
R431 T514 T512 arg1Of subtypes,different
R432 T514 T513 arg1Of subtypes,DC
R433 T514 T515 arg1Of subtypes,in
R434 T517 T515 arg2Of spleen,in
R435 T517 T516 arg1Of spleen,the
R436 T519 T518 arg2Of response,In
R437 T519 T520 arg1Of response,to
R438 T524 T523 arg2Of TLR,(
R439 T525 T523 arg3Of ),(
R440 T527 T521 arg1Of LPS,TOLL-like
R441 T527 T522 arg1Of LPS,receptor
R442 T527 T523 arg1Of LPS,(
R443 T527 T526 arg1Of LPS,agonists
R444 T527 T528 arg1Of LPS,and
R445 T528 T520 arg2Of and,to
R446 T530 T531 arg1Of I,:
R447 T531 T528 arg2Of :,and
R448 T531 T529 arg1Of :,poly
R449 T532 T531 arg2Of C,:
R450 T538 T534 arg2Of cells,cultured
R451 T538 T535 arg1Of cells,bone
R452 T538 T536 arg1Of cells,marrow-derived
R453 T538 T537 arg1Of cells,dendritic
R454 T538 T539 arg1Of cells,(
R455 T538 T542 arg1Of cells,from
R456 T538 T547 arg1Of cells,exhibited
R457 T540 T539 arg2Of BMDC,(
R458 T541 T539 arg3Of ),(
R459 T543 T544 arg1Of WT,and
R460 T545 T544 arg2Of mutant,and
R461 T546 T542 arg2Of mice,from
R462 T546 T543 arg1Of mice,WT
R463 T546 T545 arg1Of mice,mutant
R464 T547 T518 arg1Of exhibited,In
R465 T547 T533 arg1Of exhibited,","
R466 T549 T547 arg2Of increases,exhibited
R467 T549 T548 arg1Of increases,similar
R468 T549 T550 arg1Of increases,in
R469 T551 T550 arg2Of expression,in
R470 T551 T552 arg1Of expression,of
R471 T555 T556 arg1Of CD40,","
R472 T556 T559 arg1Of ",",and
R473 T557 T556 arg2Of CD80,","
R474 T559 T552 arg2Of and,of
R475 T559 T553 arg1Of and,co-stimulatory
R476 T559 T554 arg1Of and,molecules
R477 T559 T558 arg1Of and,","
R478 T560 T559 arg2Of CD86,and
R479 T565 T563 arg1Of BMDC,stimulated
R480 T565 T564 arg1Of BMDC,SHARPIN-deficient
R481 T565 T566 arg1Of BMDC,had
R482 T565 T567 arg1Of BMDC,reduced
R483 T567 T561 arg1Of reduced,However
R484 T567 T562 arg1Of reduced,","
R485 T567 T566 arg2Of reduced,had
R486 T568 T569 arg1Of transcription,and
R487 T569 T567 arg2Of and,reduced
R488 T569 T571 arg1Of and,of
R489 T570 T569 arg2Of secretion,and
R490 T573 T572 arg1Of mediators,pro-inflammatory
R491 T574 T575 arg1Of IL6,","
R492 T575 T577 arg1Of ",",","
R493 T576 T575 arg2Of IL12P70,","
R494 T577 T580 arg1Of ",",and
R495 T578 T577 arg2Of GMCSF,","
R496 T580 T571 arg2Of and,of
R497 T580 T573 arg1Of and,mediators
R498 T580 T579 arg1Of and,","
R499 T582 T580 arg2Of oxide,and
R500 T582 T581 arg1Of oxide,nitric
R501 T584 T583 arg1Of BMDC,Mutant
R502 T584 T585 arg1Of BMDC,had
R503 T585 T592 arg1Of had,whereas
R504 T587 T585 arg2Of activation,had
R505 T587 T586 arg1Of activation,defective
R506 T587 T588 arg1Of activation,of
R507 T590 T588 arg2Of signaling,of
R508 T590 T589 arg1Of signaling,NF-κB
R509 T592 T591 arg1Of whereas,","
R510 T594 T593 arg1Of MAPK1/3,the
R511 T594 T595 arg1Of MAPK1/3,(
R512 T594 T598 arg1Of MAPK1/3,and
R513 T596 T595 arg2Of ERK1/2,(
R514 T597 T595 arg3Of ),(
R515 T598 T610 arg1Of and,were
R516 T598 T611 arg1Of and,intact
R517 T599 T600 arg1Of MAPK11/12/13/14,(
R518 T599 T606 arg1Of MAPK11/12/13/14,and
R519 T604 T600 arg2Of isoforms,(
R520 T604 T601 arg1Of isoforms,p38
R521 T604 T602 arg1Of isoforms,MAP
R522 T604 T603 arg1Of isoforms,kinase
R523 T605 T600 arg3Of ),(
R524 T606 T598 arg2Of and,and
R525 T609 T606 arg2Of pathways,and
R526 T609 T607 arg1Of pathways,TBK1
R527 T609 T608 arg1Of pathways,signaling
R528 T610 T592 arg2Of were,whereas
R529 T611 T610 arg2Of intact,were
R530 T615 T612 arg1Of reaction,A
R531 T615 T613 arg1Of reaction,mixed
R532 T615 T614 arg1Of reaction,lymphocyte
R533 T615 T616 arg1Of reaction,showed
R534 T619 T618 arg1Of BMDC,mutant
R535 T619 T621 arg1Of BMDC,induced
R536 T619 T628 arg1Of BMDC,stimulated
R537 T621 T627 arg1Of induced,but
R538 T626 T621 arg2Of response,induced
R539 T626 T622 arg1Of response,a
R540 T626 T623 arg1Of response,weak
R541 T626 T624 arg1Of response,Th1
R542 T626 T625 arg1Of response,immune
R543 T627 T616 arg2Of but,showed
R544 T627 T617 arg1Of but,that
R545 T627 T620 arg1Of but,only
R546 T628 T627 arg2Of stimulated,but
R547 T628 T633 arg1Of stimulated,from
R548 T632 T628 arg2Of production,stimulated
R549 T632 T629 arg2Of production,increased
R550 T632 T630 arg1Of production,Th2
R551 T632 T631 arg1Of production,cytokine
R552 T638 T633 arg2Of cells,from
R553 T638 T634 arg1Of cells,allogeneic
R554 T638 T635 arg1Of cells,naïve
R555 T638 T636 arg1Of cells,CD4+
R556 T638 T637 arg1Of cells,T
R557 T640 T639 arg2Of conclusion,In
R558 T642 T643 arg1Of loss,of
R559 T642 T645 arg1Of loss,in
R560 T642 T648 arg1Of loss,affects
R561 T644 T643 arg2Of Sharpin,of
R562 T646 T645 arg2Of mice,in
R563 T648 T647 arg1Of affects,significantly
R564 T648 T654 arg1Of affects,and
R565 T651 T648 arg2Of function,affects
R566 T651 T649 arg1Of function,the
R567 T651 T650 arg1Of function,immune
R568 T651 T652 arg1Of function,of
R569 T653 T652 arg2Of DC,of
R570 T654 T639 arg1Of and,In
R571 T654 T641 arg1Of and,","
R572 T655 T656 arg1Of this,may
R573 T655 T658 arg1Of this,account
R574 T658 T654 arg2Of account,and
R575 T658 T656 arg2Of account,may
R576 T658 T657 arg1Of account,partially
R577 T658 T659 arg1Of account,for
R578 T662 T661 arg1Of inflammation,systemic
R579 T662 T663 arg1Of inflammation,and
R580 T663 T659 arg2Of and,for
R581 T663 T660 arg1Of and,the
R582 T666 T663 arg2Of response,and
R583 T666 T664 arg1Of response,Th2-biased
R584 T666 T665 arg1Of response,immune