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PMC:3279418 JSONTXT 20 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T399 0-7 NN denotes SHARPIN
T400 8-10 VB denotes Is
T401 11-20 JJ denotes Essential
T402 21-24 IN denotes for
T403 25-33 NN denotes Cytokine
T404 34-44 NN denotes Production
T405 44-45 -COMMA- denotes ,
T406 46-51 NN denotes NF-κB
T407 52-61 NN denotes Signaling
T408 61-62 -COMMA- denotes ,
T409 63-66 CC denotes and
T410 67-76 NN denotes Induction
T411 77-79 IN denotes of
T412 80-83 NN denotes Th1
T413 84-99 NN denotes Differentiation
T414 100-102 IN denotes by
T415 103-112 JJ denotes Dendritic
T416 113-118 NN denotes Cells
T417 165-176 JJ denotes Spontaneous
T418 177-186 NN denotes mutations
T419 187-189 IN denotes of
T420 190-193 DT denotes the
T421 194-201 NNP denotes Sharpin
T422 202-203 -LRB- denotes (
T423 203-219 JJ denotes SHANK-associated
T424 220-222 NN denotes RH
T425 223-241 JJ denotes domain-interacting
T426 242-249 NN denotes protein
T427 249-250 -COMMA- denotes ,
T428 251-256 JJ denotes other
T429 257-264 NN denotes aliases
T430 264-265 -COLON- denotes :
T431 266-272 NN denotes Rbckl1
T432 272-273 -COMMA- denotes ,
T433 274-279 NN denotes Sipl1
T434 279-280 -RRB- denotes )
T435 281-285 NN denotes gene
T436 286-288 IN denotes in
T437 289-293 NN denotes mice
T438 294-300 VB denotes result
T439 301-303 IN denotes in
T440 304-312 JJ denotes systemic
T441 313-325 NN denotes inflammation
T442 326-330 WDT denotes that
T443 331-333 VB denotes is
T444 334-347 VB denotes characterized
T445 348-350 IN denotes by
T446 351-358 JJ denotes chronic
T447 359-372 JJ denotes proliferative
T448 373-383 NN denotes dermatitis
T449 384-387 CC denotes and
T450 388-400 VB denotes dysregulated
T451 401-410 NN denotes secretion
T452 411-413 IN denotes of
T453 414-415 NN denotes T
T454 416-423 NN denotes helper1
T455 424-425 -LRB- denotes (
T456 425-428 NN denotes Th1
T457 428-429 -RRB- denotes )
T458 430-433 CC denotes and
T459 434-437 NN denotes Th2
T460 438-447 NN denotes cytokines
T461 449-452 DT denotes The
T462 453-461 JJ denotes cellular
T463 462-465 CC denotes and
T464 466-475 JJ denotes molecular
T465 476-486 NN denotes mechanisms
T466 487-497 VB denotes underlying
T467 498-502 DT denotes this
T468 503-515 JJ denotes inflammatory
T469 516-525 NN denotes phenotype
T470 526-532 VB denotes remain
T471 533-540 JJ denotes elusive
T472 542-551 JJ denotes Dendritic
T473 552-557 NN denotes cells
T474 558-561 MD denotes may
T475 562-572 VB denotes contribute
T476 573-575 TO denotes to
T477 576-579 DT denotes the
T478 580-590 NN denotes initiation
T479 591-594 CC denotes and
T480 595-606 NN denotes progression
T481 607-609 IN denotes of
T482 610-613 DT denotes the
T483 614-623 NN denotes phenotype
T484 624-626 IN denotes of
T485 627-644 JJ denotes SHARPIN-deficient
T486 645-649 NN denotes mice
T487 650-657 IN denotes because
T488 658-660 IN denotes of
T489 661-666 PRP-DOLLAR- denotes their
T490 667-674 JJ denotes pivotal
T491 675-679 NN denotes role
T492 680-682 IN denotes in
T493 683-689 JJ denotes innate
T494 690-693 CC denotes and
T495 694-702 JJ denotes adaptive
T496 703-711 NN denotes immunity
T497 713-717 RB denotes Here
T498 718-720 PRP denotes we
T499 721-725 VB denotes show
T500 726-728 IN denotes by
T501 729-733 NN denotes flow
T502 734-743 NN denotes cytometry
T503 744-748 IN denotes that
T504 749-757 NN denotes SHARPIN-
T505 758-768 NN denotes deficiency
T506 769-772 VB denotes did
T507 773-776 RB denotes not
T508 777-782 VB denotes alter
T509 783-786 DT denotes the
T510 787-799 NN denotes distribution
T511 800-802 IN denotes of
T512 803-812 JJ denotes different
T513 813-815 NN denotes DC
T514 816-824 NN denotes subtypes
T515 825-827 IN denotes in
T516 828-831 DT denotes the
T517 832-838 NN denotes spleen
T518 840-842 IN denotes In
T519 843-851 NN denotes response
T520 852-854 TO denotes to
T521 855-864 JJ denotes TOLL-like
T522 865-873 NN denotes receptor
T523 874-875 -LRB- denotes (
T524 875-878 NN denotes TLR
T525 878-879 -RRB- denotes )
T526 880-888 NN denotes agonists
T527 889-892 NN denotes LPS
T528 893-896 CC denotes and
T529 897-901 NN denotes poly
T530 902-903 NN denotes I
T531 903-904 -COLON- denotes :
T532 904-905 NN denotes C
T533 905-906 -COMMA- denotes ,
T534 907-915 VB denotes cultured
T535 916-920 NN denotes bone
T536 921-935 JJ denotes marrow-derived
T537 936-945 JJ denotes dendritic
T538 946-951 NN denotes cells
T539 952-953 -LRB- denotes (
T540 953-957 NN denotes BMDC
T541 957-958 -RRB- denotes )
T542 959-963 IN denotes from
T543 964-966 NN denotes WT
T544 967-970 CC denotes and
T545 971-977 JJ denotes mutant
T546 978-982 NN denotes mice
T547 983-992 VB denotes exhibited
T548 993-1000 JJ denotes similar
T549 1001-1010 NN denotes increases
T550 1011-1013 IN denotes in
T551 1014-1024 NN denotes expression
T552 1025-1027 IN denotes of
T553 1028-1042 JJ denotes co-stimulatory
T554 1043-1052 NN denotes molecules
T555 1053-1057 NN denotes CD40
T556 1057-1058 -COMMA- denotes ,
T557 1059-1063 NN denotes CD80
T558 1063-1064 -COMMA- denotes ,
T559 1065-1068 CC denotes and
T560 1069-1073 NN denotes CD86
T561 1075-1082 RB denotes However
T562 1082-1083 -COMMA- denotes ,
T563 1084-1094 VB denotes stimulated
T564 1095-1112 JJ denotes SHARPIN-deficient
T565 1113-1117 NN denotes BMDC
T566 1118-1121 VB denotes had
T567 1122-1129 VB denotes reduced
T568 1130-1143 NN denotes transcription
T569 1144-1147 CC denotes and
T570 1148-1157 NN denotes secretion
T571 1158-1160 IN denotes of
T572 1161-1177 JJ denotes pro-inflammatory
T573 1178-1187 NN denotes mediators
T574 1188-1191 NN denotes IL6
T575 1191-1192 -COMMA- denotes ,
T576 1193-1200 NN denotes IL12P70
T577 1200-1201 -COMMA- denotes ,
T578 1202-1207 NN denotes GMCSF
T579 1207-1208 -COMMA- denotes ,
T580 1209-1212 CC denotes and
T581 1213-1219 JJ denotes nitric
T582 1220-1225 NN denotes oxide
T583 1227-1233 JJ denotes Mutant
T584 1234-1238 NN denotes BMDC
T585 1239-1242 VB denotes had
T586 1243-1252 JJ denotes defective
T587 1253-1263 NN denotes activation
T588 1264-1266 IN denotes of
T589 1267-1272 NN denotes NF-κB
T590 1273-1282 NN denotes signaling
T591 1282-1283 -COMMA- denotes ,
T592 1284-1291 IN denotes whereas
T593 1292-1295 DT denotes the
T594 1296-1303 NN denotes MAPK1/3
T595 1304-1305 -LRB- denotes (
T596 1305-1311 NN denotes ERK1/2
T597 1311-1312 -RRB- denotes )
T598 1313-1316 CC denotes and
T599 1317-1332 NN denotes MAPK11/12/13/14
T600 1333-1334 -LRB- denotes (
T601 1334-1337 NN denotes p38
T602 1338-1341 NN denotes MAP
T603 1342-1348 NN denotes kinase
T604 1349-1357 NN denotes isoforms
T605 1357-1358 -RRB- denotes )
T606 1359-1362 CC denotes and
T607 1363-1367 NN denotes TBK1
T608 1368-1377 NN denotes signaling
T609 1378-1386 NN denotes pathways
T610 1387-1391 VB denotes were
T611 1392-1398 JJ denotes intact
T612 1400-1401 DT denotes A
T613 1402-1407 JJ denotes mixed
T614 1408-1418 NN denotes lymphocyte
T615 1419-1427 NN denotes reaction
T616 1428-1434 VB denotes showed
T617 1435-1439 IN denotes that
T618 1440-1446 JJ denotes mutant
T619 1447-1451 NN denotes BMDC
T620 1452-1456 RB denotes only
T621 1457-1464 VB denotes induced
T622 1465-1466 DT denotes a
T623 1467-1471 JJ denotes weak
T624 1472-1475 NN denotes Th1
T625 1476-1482 JJ denotes immune
T626 1483-1491 NN denotes response
T627 1492-1495 CC denotes but
T628 1496-1506 VB denotes stimulated
T629 1507-1516 VB denotes increased
T630 1517-1520 NN denotes Th2
T631 1521-1529 NN denotes cytokine
T632 1530-1540 NN denotes production
T633 1541-1545 IN denotes from
T634 1546-1556 JJ denotes allogeneic
T635 1557-1562 NN denotes naïve
T636 1563-1567 JJ denotes CD4+
T637 1568-1569 NN denotes T
T638 1570-1575 NN denotes cells
T639 1577-1579 IN denotes In
T640 1580-1590 NN denotes conclusion
T641 1590-1591 -COMMA- denotes ,
T642 1592-1596 NN denotes loss
T643 1597-1599 IN denotes of
T644 1600-1607 NN denotes Sharpin
T645 1608-1610 IN denotes in
T646 1611-1615 NN denotes mice
T647 1616-1629 RB denotes significantly
T648 1630-1637 VB denotes affects
T649 1638-1641 DT denotes the
T650 1642-1648 JJ denotes immune
T651 1649-1657 NN denotes function
T652 1658-1660 IN denotes of
T653 1661-1663 NN denotes DC
T654 1664-1667 CC denotes and
T655 1668-1672 DT denotes this
T656 1673-1676 MD denotes may
T657 1677-1686 RB denotes partially
T658 1687-1694 VB denotes account
T659 1695-1698 IN denotes for
T660 1699-1702 DT denotes the
T661 1703-1711 JJ denotes systemic
T662 1712-1724 NN denotes inflammation
T663 1725-1728 CC denotes and
T664 1729-1739 JJ denotes Th2-biased
T665 1740-1746 JJ denotes immune
T666 1747-1755 NN denotes response
T1486 1771-1778 NN denotes SHARPIN
T1487 1779-1782 VB denotes was
T1488 1783-1793 RB denotes originally
T1489 1794-1804 VB denotes identified
T1490 1805-1807 IN denotes in
T1491 1808-1821 JJ denotes post-synaptic
T1492 1822-1831 NN denotes densities
T1493 1832-1834 IN denotes of
T1494 1835-1845 JJ denotes excitatory
T1495 1846-1854 NN denotes synapses
T1496 1855-1857 IN denotes in
T1497 1858-1861 DT denotes the
T1498 1862-1867 NN denotes brain
T1499 1868-1870 IN denotes of
T1500 1871-1875 NN denotes rats
T1501 1876-1877 -LRB- denotes [
T1502 1877-1878 CD denotes 1
T1503 1878-1879 -RRB- denotes ]
T1504 1879-1880 -COMMA- denotes ,
T1505 1881-1884 CC denotes but
T1506 1885-1889 DT denotes this
T1507 1890-1897 NN denotes protein
T1508 1898-1900 VB denotes is
T1509 1901-1907 RB denotes widely
T1510 1908-1917 VB denotes expressed
T1511 1918-1920 IN denotes in
T1512 1921-1922 DT denotes a
T1513 1923-1930 NN denotes variety
T1514 1931-1933 IN denotes of
T1515 1934-1941 NN denotes tissues
T1516 1942-1943 -LRB- denotes [
T1517 1943-1944 CD denotes 2
T1518 1944-1945 -RRB- denotes ]
T1519 1947-1950 CD denotes Two
T1520 1951-1958 JJ denotes allelic
T1521 1958-1959 -COMMA- denotes ,
T1522 1960-1969 JJ denotes autosomal
T1523 1970-1979 JJ denotes recessive
T1524 1980-1989 NN denotes mutations
T1525 1990-1992 IN denotes in
T1526 1993-1996 DT denotes the
T1527 1997-2004 NN denotes Sharpin
T1528 2005-2009 NN denotes gene
T1529 2010-2018 VB denotes occurred
T1530 2019-2032 RB denotes spontaneously
T1531 2033-2035 IN denotes in
T1532 2036-2039 CD denotes two
T1533 2040-2046 JJ denotes inbred
T1534 2047-2054 NN denotes strains
T1535 2055-2057 IN denotes of
T1536 2058-2062 NN denotes mice
T1537 2062-2063 -COMMA- denotes ,
T1538 2064-2101 NN denotes C57B/KaLawRij-Sharpincpdm/Sharpincpdm
T1539 2102-2105 CC denotes and
T1540 2106-2150 NN denotes CBy.Ocb3/Dem-Sharpincpdm-Dem/Sharpincpdm-Dem
T1541 2150-2151 -COMMA- denotes ,
T1542 2152-2161 VB denotes resulting
T1543 2162-2164 IN denotes in
T1544 2165-2174 JJ denotes premature
T1545 2175-2186 NN denotes termination
T1546 2187-2189 IN denotes of
T1547 2190-2194 NN denotes mRNA
T1548 2195-2204 NN denotes synthesis
T1549 2205-2208 CC denotes and
T1550 2209-2216 NN denotes absence
T1551 2217-2219 IN denotes of
T1552 2220-2221 DT denotes a
T1553 2222-2232 JJ denotes functional
T1554 2233-2240 NN denotes protein
T1555 2241-2248 NN denotes product
T1556 2249-2250 -LRB- denotes [
T1557 2250-2251 CD denotes 2
T1558 2251-2252 -RRB- denotes ]
T1559 2254-2261 IN denotes Despite
T1560 2262-2271 JJ denotes different
T1561 2272-2279 JJ denotes genetic
T1562 2280-2291 NN denotes backgrounds
T1563 2291-2292 -COMMA- denotes ,
T1564 2293-2297 DT denotes both
T1565 2298-2307 NN denotes mutations
T1566 2308-2313 VB denotes cause
T1567 2314-2321 JJ denotes similar
T1568 2322-2334 JJ denotes inflammatory
T1569 2335-2342 NN denotes disease
T1570 2343-2347 IN denotes with
T1571 2348-2354 JJ denotes severe
T1572 2355-2362 JJ denotes chronic
T1573 2363-2374 JJ denotes progressive
T1574 2375-2385 NN denotes dermatitis
T1575 2386-2389 CC denotes and
T1576 2390-2399 JJ denotes defective
T1577 2400-2411 NN denotes development
T1578 2412-2414 IN denotes of
T1579 2415-2424 JJ denotes secondary
T1580 2425-2433 JJ denotes lymphoid
T1581 2434-2440 NN denotes organs
T1582 2441-2442 -LRB- denotes [
T1583 2442-2443 CD denotes 2
T1584 2443-2444 -RRB- denotes ]
T1585 2444-2445 NN denotes –
T1586 2445-2446 -LRB- denotes [
T1587 2446-2447 CD denotes 4
T1588 2447-2448 -RRB- denotes ]
T1589 2450-2453 DT denotes The
T1590 2454-2464 NN denotes dermatitis
T1591 2465-2472 VB denotes becomes
T1592 2473-2483 RB denotes clinically
T1593 2484-2492 JJ denotes apparent
T1594 2493-2495 IN denotes at
T1595 2496-2501 RB denotes about
T1596 2502-2506 CD denotes four
T1597 2507-2512 NN denotes weeks
T1598 2513-2515 IN denotes of
T1599 2516-2519 NN denotes age
T1600 2521-2526 EX denotes There
T1601 2527-2530 VB denotes are
T1602 2531-2544 NN denotes accumulations
T1603 2545-2547 IN denotes of
T1604 2548-2559 NN denotes eosinophils
T1605 2559-2560 -COMMA- denotes ,
T1606 2561-2572 NN denotes neutrophils
T1607 2573-2576 CC denotes and
T1608 2577-2588 NN denotes macrophages
T1609 2589-2591 IN denotes in
T1610 2592-2595 DT denotes the
T1611 2596-2600 NN denotes skin
T1612 2601-2603 IN denotes of
T1613 2604-2627 NNP denotes Sharpincpdm/Sharpincpdm
T1614 2628-2634 JJ denotes mutant
T1615 2635-2639 NN denotes mice
T1616 2640-2641 -LRB- denotes (
T1617 2641-2650 RB denotes hereafter
T1618 2651-2659 VB denotes referred
T1619 2660-2662 TO denotes to
T1620 2663-2665 IN denotes as
T1621 2666-2670 NN denotes cpdm
T1622 2671-2675 NN denotes mice
T1623 2675-2676 -RRB- denotes )
T1624 2677-2687 VB denotes associated
T1625 2688-2692 IN denotes with
T1626 2693-2702 VB denotes increased
T1627 2703-2713 NN denotes expression
T1628 2714-2716 IN denotes of
T1629 2717-2720 NN denotes Th2
T1630 2721-2730 NN denotes cytokines
T1631 2731-2733 IN denotes in
T1632 2734-2737 DT denotes the
T1633 2738-2742 NN denotes skin
T1634 2743-2746 CC denotes and
T1635 2747-2749 IN denotes in
T1636 2750-2753 DT denotes the
T1637 2754-2766 NN denotes supernatants
T1638 2767-2769 IN denotes of
T1639 2770-2779 VB denotes activated
T1640 2780-2791 NN denotes splenocytes
T1641 2792-2793 -LRB- denotes [
T1642 2793-2794 CD denotes 5
T1643 2794-2795 -RRB- denotes ]
T1644 2797-2800 DT denotes The
T1645 2801-2805 NN denotes mice
T1646 2806-2810 VB denotes have
T1647 2811-2813 DT denotes an
T1648 2814-2822 JJ denotes impaired
T1649 2823-2830 VB denotes delayed
T1650 2831-2835 NN denotes type
T1651 2836-2852 NN denotes hypersensitivity
T1652 2853-2861 NN denotes response
T1653 2862-2865 CC denotes and
T1654 2866-2875 VB denotes decreased
T1655 2876-2885 NN denotes secretion
T1656 2886-2888 IN denotes of
T1657 2889-2893 NN denotes IFNγ
T1658 2894-2895 -LRB- denotes [
T1659 2895-2896 CD denotes 5
T1660 2896-2897 -RRB- denotes ]
T1661 2897-2898 -COMMA- denotes ,
T1662 2899-2909 VB denotes indicating
T1663 2910-2911 DT denotes a
T1664 2912-2918 NN denotes defect
T1665 2919-2921 IN denotes in
T1666 2922-2925 NN denotes Th1
T1667 2926-2932 JJ denotes immune
T1668 2933-2942 NN denotes responses
T1669 2943-2946 CC denotes and
T1670 2947-2948 DT denotes a
T1671 2949-2953 NN denotes bias
T1672 2954-2961 IN denotes towards
T1673 2962-2963 DT denotes a
T1674 2964-2967 NN denotes Th2
T1675 2968-2974 JJ denotes immune
T1676 2975-2983 NN denotes response
T1677 2985-2993 JJ denotes Systemic
T1678 2994-3003 NN denotes treatment
T1679 3004-3006 IN denotes of
T1680 3007-3011 NN denotes cpdm
T1681 3012-3016 NN denotes mice
T1682 3017-3021 IN denotes with
T1683 3022-3033 JJ denotes recombinant
T1684 3034-3038 NN denotes IL12
T1685 3039-3045 VB denotes caused
T1686 3046-3054 JJ denotes complete
T1687 3055-3064 NN denotes remission
T1688 3065-3067 IN denotes of
T1689 3068-3071 DT denotes the
T1690 3072-3082 NN denotes dermatitis
T1691 3083-3084 -LRB- denotes [
T1692 3084-3085 CD denotes 5
T1693 3085-3086 -RRB- denotes ]
T1694 3088-3102 NN denotes Neutralization
T1695 3103-3105 IN denotes of
T1696 3106-3109 NN denotes IL5
T1697 3110-3112 IN denotes by
T1698 3113-3121 NN denotes antibody
T1699 3122-3131 NN denotes treatment
T1700 3132-3134 CC denotes or
T1701 3135-3142 NN denotes crosses
T1702 3143-3147 IN denotes with
T1703 3148-3161 JJ denotes IL5-deficient
T1704 3162-3166 NN denotes mice
T1705 3167-3174 VB denotes reduced
T1706 3175-3178 DT denotes the
T1707 3179-3185 NN denotes number
T1708 3186-3188 IN denotes of
T1709 3189-3200 VB denotes circulating
T1710 3201-3204 CC denotes and
T1711 3205-3214 JJ denotes cutaneous
T1712 3215-3226 NN denotes eosinophils
T1713 3226-3227 -COMMA- denotes ,
T1714 3228-3231 CC denotes but
T1715 3232-3238 VB denotes failed
T1716 3239-3241 TO denotes to
T1717 3242-3248 VB denotes reduce
T1718 3249-3252 DT denotes the
T1719 3253-3258 NN denotes onset
T1720 3259-3262 CC denotes and
T1721 3263-3271 NN denotes severity
T1722 3272-3274 IN denotes of
T1723 3275-3278 DT denotes the
T1724 3279-3289 NN denotes dermatitis
T1725 3290-3291 -LRB- denotes [
T1726 3291-3292 CD denotes 6
T1727 3292-3293 -RRB- denotes ]
T1728 3295-3303 RB denotes Recently
T1729 3303-3304 -COMMA- denotes ,
T1730 3305-3310 CD denotes three
T1731 3311-3322 JJ denotes independent
T1732 3323-3329 NN denotes groups
T1733 3330-3340 VB denotes identified
T1734 3341-3348 NN denotes SHARPIN
T1735 3349-3351 IN denotes as
T1736 3352-3354 DT denotes an
T1737 3355-3364 JJ denotes essential
T1738 3365-3374 NN denotes component
T1739 3375-3377 IN denotes of
T1740 3378-3381 DT denotes the
T1741 3382-3388 JJ denotes linear
T1742 3389-3398 NN denotes ubiquitin
T1743 3399-3404 NN denotes chain
T1744 3405-3413 NN denotes assembly
T1745 3414-3421 NN denotes complex
T1746 3422-3423 -LRB- denotes (
T1747 3423-3428 NN denotes LUBAC
T1748 3428-3429 -RRB- denotes )
T1749 3430-3434 WDT denotes that
T1750 3435-3444 VB denotes regulates
T1751 3445-3457 JJ denotes TNFα-induced
T1752 3458-3467 JJ denotes canonical
T1753 3468-3473 NN denotes NF-κB
T1754 3474-3483 NN denotes signaling
T1755 3484-3485 -LRB- denotes [
T1756 3485-3486 CD denotes 7
T1757 3486-3487 -RRB- denotes ]
T1758 3487-3488 NN denotes –
T1759 3488-3489 -LRB- denotes [
T1760 3489-3490 CD denotes 9
T1761 3490-3491 -RRB- denotes ]
T1762 3493-3510 JJ denotes SHARPIN-deficient
T1763 3511-3516 NN denotes mouse
T1764 3517-3526 JJ denotes embryonic
T1765 3527-3537 NN denotes fibroblast
T1766 3538-3539 -LRB- denotes (
T1767 3539-3542 NN denotes MEF
T1768 3542-3543 -RRB- denotes )
T1769 3544-3548 VB denotes were
T1770 3549-3559 VB denotes sensitized
T1771 3560-3562 TO denotes to
T1772 3563-3575 JJ denotes TNFα-induced
T1773 3576-3585 NN denotes apoptosis
T1774 3586-3589 CC denotes and
T1775 3590-3594 NN denotes cell
T1776 3595-3600 NN denotes death
T1777 3601-3604 VB denotes was
T1778 3605-3615 VB denotes implicated
T1779 3616-3618 IN denotes as
T1780 3619-3620 DT denotes a
T1781 3621-3627 NN denotes factor
T1782 3628-3630 IN denotes in
T1783 3631-3634 DT denotes the
T1784 3635-3645 NN denotes dermatitis
T1785 3646-3648 IN denotes of
T1786 3649-3653 NN denotes cpdm
T1787 3654-3658 NN denotes mice
T1788 3659-3660 -LRB- denotes [
T1789 3660-3661 CD denotes 7
T1790 3661-3662 -RRB- denotes ]
T1791 3662-3663 NN denotes –
T1792 3663-3664 -LRB- denotes [
T1793 3664-3665 CD denotes 9
T1794 3665-3666 -RRB- denotes ]
T1795 3668-3677 JJ denotes Dendritic
T1796 3678-3683 NN denotes cells
T1797 3684-3685 -LRB- denotes (
T1798 3685-3687 NN denotes DC
T1799 3687-3688 -RRB- denotes )
T1800 3689-3693 VB denotes have
T1801 3694-3695 DT denotes a
T1802 3696-3704 NN denotes sentinel
T1803 3705-3709 NN denotes role
T1804 3710-3712 IN denotes in
T1805 3713-3720 VB denotes sensing
T1806 3721-3729 NN denotes pathogen
T1807 3730-3732 CC denotes or
T1808 3733-3739 NN denotes danger
T1809 3740-3747 NN denotes signals
T1810 3748-3751 CC denotes and
T1811 3752-3760 NN denotes initiate
T1812 3761-3764 CC denotes and
T1813 3765-3771 JJ denotes direct
T1814 3772-3782 NN denotes activation
T1815 3783-3785 IN denotes of
T1816 3786-3789 DT denotes the
T1817 3790-3798 JJ denotes adaptive
T1818 3799-3805 JJ denotes immune
T1819 3806-3814 NN denotes response
T1820 3815-3816 -LRB- denotes [
T1821 3816-3818 CD denotes 10
T1822 3818-3819 -RRB- denotes ]
T1823 3821-3830 VB denotes Activated
T1824 3831-3834 CC denotes and
T1825 3835-3841 JJ denotes mature
T1826 3842-3844 NN denotes DC
T1827 3845-3848 MD denotes can
T1828 3849-3854 VB denotes carry
T1829 3855-3864 VB denotes processed
T1830 3865-3874 JJ denotes antigenic
T1831 3875-3883 NN denotes peptides
T1832 3883-3884 -COMMA- denotes ,
T1833 3885-3892 VB denotes migrate
T1834 3893-3895 TO denotes to
T1835 3896-3904 JJ denotes lymphoid
T1836 3905-3911 NN denotes organs
T1837 3911-3912 -COMMA- denotes ,
T1838 3913-3916 CC denotes and
T1839 3917-3923 VB denotes induce
T1840 3924-3939 JJ denotes T-cell-mediated
T1841 3940-3946 JJ denotes immune
T1842 3947-3956 NN denotes responses
T1843 3957-3959 CC denotes or
T1844 3960-3969 NN denotes tolerance
T1845 3971-3973 NN denotes DC
T1846 3974-3980 VB denotes direct
T1847 3981-3984 DT denotes the
T1848 3985-4000 NN denotes differentiation
T1849 4001-4003 IN denotes of
T1850 4004-4008 JJ denotes CD4+
T1851 4009-4010 NN denotes T
T1852 4011-4016 NN denotes cells
T1853 4016-4017 -COMMA- denotes ,
T1854 4018-4021 CC denotes and
T1855 4022-4027 RB denotes hence
T1856 4028-4031 DT denotes the
T1857 4032-4036 NN denotes type
T1858 4037-4039 IN denotes of
T1859 4040-4046 JJ denotes immune
T1860 4047-4055 NN denotes response
T1861 4055-4056 -COMMA- denotes ,
T1862 4057-4064 IN denotes through
T1863 4065-4068 DT denotes the
T1864 4069-4078 JJ denotes selective
T1865 4079-4088 NN denotes secretion
T1866 4089-4091 IN denotes of
T1867 4092-4101 NN denotes cytokines
T1868 4103-4105 PRP denotes We
T1869 4106-4118 VB denotes hypothesized
T1870 4119-4123 IN denotes that
T1871 4124-4133 JJ denotes defective
T1872 4134-4142 NN denotes cytokine
T1873 4143-4152 NN denotes secretion
T1874 4153-4155 IN denotes by
T1875 4156-4158 NN denotes DC
T1876 4159-4170 VB denotes contributed
T1877 4171-4173 TO denotes to
T1878 4174-4177 DT denotes the
T1879 4178-4188 JJ denotes Th2-biased
T1880 4189-4201 JJ denotes inflammatory
T1881 4202-4211 NN denotes phenotype
T1882 4212-4214 IN denotes in
T1883 4215-4232 JJ denotes SHARPIN-deficient
T1884 4233-4237 NN denotes mice
T1885 4239-4242 DT denotes The
T1886 4243-4250 NN denotes studies
T1887 4251-4259 VB denotes reported
T1888 4260-4264 RB denotes here
T1889 4265-4270 VB denotes found
T1890 4271-4275 IN denotes that
T1891 4276-4280 NN denotes lack
T1892 4281-4283 IN denotes of
T1893 4284-4291 NN denotes SHARPIN
T1894 4292-4299 NN denotes protein
T1895 4300-4302 IN denotes in
T1896 4303-4307 NN denotes BMDC
T1897 4308-4314 VB denotes caused
T1898 4315-4324 JJ denotes defective
T1899 4325-4335 NN denotes expression
T1900 4336-4338 IN denotes of
T1901 4339-4355 JJ denotes pro-inflammatory
T1902 4356-4365 NN denotes mediators
T1903 4366-4369 CC denotes and
T1904 4370-4378 JJ denotes impaired
T1905 4379-4384 NN denotes NF-κB
T1906 4385-4395 NN denotes activation
T1907 4396-4400 IN denotes upon
T1908 4401-4407 NN denotes ligand
T1909 4408-4419 NN denotes stimulation
T1910 4421-4424 DT denotes The
T1911 4425-4432 NN denotes ability
T1912 4433-4435 IN denotes of
T1913 4436-4440 NN denotes cpdm
T1914 4441-4445 NN denotes BMDC
T1915 4446-4448 TO denotes to
T1916 4449-4458 VB denotes stimulate
T1917 4459-4462 NN denotes Th1
T1918 4463-4471 NN denotes cytokine
T1919 4472-4482 NN denotes production
T1920 4483-4485 IN denotes in
T1921 4486-4496 JJ denotes allogeneic
T1922 4497-4501 JJ denotes CD4+
T1923 4502-4503 NN denotes T
T1924 4504-4509 NN denotes cells
T1925 4510-4513 VB denotes was
T1926 4514-4525 VB denotes compromised
T1927 4527-4532 VB denotes Taken
T1928 4533-4541 RB denotes together
T1929 4541-4542 -COMMA- denotes ,
T1930 4543-4548 DT denotes these
T1931 4549-4556 NN denotes results
T1932 4557-4563 VB denotes reveal
T1933 4564-4568 IN denotes that
T1934 4569-4576 NN denotes SHARPIN
T1935 4577-4579 VB denotes is
T1936 4580-4581 DT denotes a
T1937 4582-4587 JJ denotes novel
T1938 4588-4598 JJ denotes regulatory
T1939 4599-4607 NN denotes molecule
T1940 4608-4610 IN denotes in
T1941 4611-4613 NN denotes DC
T1942 4614-4621 NN denotes biology
T1943 4622-4625 CC denotes and
T1944 4626-4633 VB denotes suggest
T1945 4634-4638 IN denotes that
T1946 4639-4642 DT denotes the
T1947 4643-4655 VB denotes dysregulated
T1948 4656-4664 NN denotes function
T1949 4665-4667 IN denotes of
T1950 4668-4685 JJ denotes SHARPIN-deficient
T1951 4686-4688 NN denotes DC
T1952 4689-4694 VB denotes plays
T1953 4695-4696 DT denotes a
T1954 4697-4701 NN denotes role
T1955 4702-4704 IN denotes in
T1956 4705-4708 DT denotes the
T1957 4709-4713 NN denotes cpdm
T1958 4714-4723 NN denotes phenotype
T2461 4735-4751 NN denotes Characterization
T2462 4752-4754 IN denotes of
T2463 4755-4762 NNP denotes Sharpin
T2464 4764-4773 NN denotes Orthologs
T2465 4774-4776 IN denotes of
T2466 4777-4784 NN denotes SHARPIN
T2467 4785-4792 NN denotes protein
T2468 4793-4796 VB denotes are
T2469 4797-4802 VB denotes found
T2470 4803-4805 IN denotes in
T2471 4806-4813 JJ denotes various
T2472 4814-4821 NN denotes species
T2473 4821-4822 -COMMA- denotes ,
T2474 4823-4832 VB denotes including
T2475 4833-4838 JJ denotes human
T2476 4838-4839 -COMMA- denotes ,
T2477 4840-4845 NN denotes mouse
T2478 4846-4849 CC denotes and
T2479 4850-4853 NN denotes rat
T2480 4855-4860 NN denotes Motif
T2481 4861-4871 NN denotes prediction
T2482 4872-4883 NN denotes programming
T2483 4883-4884 -COMMA- denotes ,
T2484 4885-4890 VB denotes using
T2485 4891-4896 NN denotes COILS
T2486 4897-4898 -LRB- denotes [
T2487 4898-4900 CD denotes 11
T2488 4900-4901 -RRB- denotes ]
T2489 4902-4905 CC denotes and
T2490 4906-4915 NNP denotes MotifScan
T2491 4916-4917 -LRB- denotes [
T2492 4917-4919 CD denotes 12
T2493 4919-4920 -RRB- denotes ]
T2494 4920-4921 -COMMA- denotes ,
T2495 4922-4930 VB denotes suggests
T2496 4931-4935 IN denotes that
T2497 4936-4943 NN denotes SHARPIN
T2498 4944-4952 VB denotes contains
T2499 4953-4954 DT denotes a
T2500 4955-4966 NN denotes coiled-coil
T2501 4967-4968 -LRB- denotes (
T2502 4968-4970 NN denotes CC
T2503 4970-4971 -RRB- denotes )
T2504 4972-4978 NN denotes domain
T2505 4978-4979 -COMMA- denotes ,
T2506 4980-4981 DT denotes a
T2507 4982-4996 JJ denotes ubiquitin-like
T2508 4997-4998 -LRB- denotes (
T2509 4998-5001 NN denotes UBL
T2510 5001-5002 -RRB- denotes )
T2511 5003-5009 NN denotes domain
T2512 5009-5010 -COMMA- denotes ,
T2513 5011-5014 CC denotes and
T2514 5015-5016 DT denotes a
T2515 5017-5028 JJ denotes zinc-finger
T2516 5029-5040 JJ denotes Ran-binding
T2517 5041-5048 NN denotes protein
T2518 5049-5050 CD denotes 2
T2519 5051-5052 -LRB- denotes (
T2520 5052-5057 NN denotes ZFRBP
T2521 5057-5058 -RRB- denotes )
T2522 5059-5065 NN denotes domain
T2523 5067-5072 DT denotes These
T2524 5073-5083 JJ denotes functional
T2525 5084-5090 NN denotes motifs
T2526 5091-5101 VB denotes constitute
T2527 5102-5109 JJ denotes similar
T2528 5110-5116 NN denotes domain
T2529 5117-5125 NN denotes profiles
T2530 5126-5130 WDT denotes that
T2531 5131-5134 VB denotes are
T2532 5135-5142 JJ denotes present
T2533 5143-5145 IN denotes in
T2534 5146-5149 DT denotes the
T2535 5150-5157 NN denotes SHARPIN
T2536 5158-5165 NN denotes protein
T2537 5166-5168 IN denotes of
T2538 5169-5172 DT denotes all
T2539 5173-5178 CD denotes three
T2540 5179-5186 NN denotes origins
T2541 5187-5188 -LRB- denotes (
T2542 5188-5192 NNP denotes Fig.
T2543 5193-5195 NN denotes 1A
T2544 5195-5196 -RRB- denotes )
T2545 5196-5197 -COMMA- denotes ,
T2546 5198-5208 VB denotes suggesting
T2547 5209-5213 IN denotes that
T2548 5214-5221 NN denotes SHARPIN
T2549 5222-5228 NN denotes exerts
T2550 5229-5235 RB denotes highly
T2551 5236-5245 VB denotes conserved
T2552 5246-5255 NN denotes functions
T2553 5256-5262 IN denotes across
T2554 5263-5270 NN denotes species
T2555 5272-5283 JJ denotes Spontaneous
T2556 5284-5293 NN denotes mutations
T2557 5294-5296 IN denotes in
T2558 5297-5300 DT denotes the
T2559 5301-5306 NN denotes mouse
T2560 5307-5314 NN denotes Sharpin
T2561 5315-5319 NN denotes gene
T2562 5320-5327 VB denotes results
T2563 5328-5330 IN denotes in
T2564 5331-5332 DT denotes a
T2565 5333-5340 JJ denotes complex
T2566 5341-5353 JJ denotes inflammatory
T2567 5354-5363 NN denotes phenotype
T2568 5364-5377 VB denotes characterized
T2569 5378-5380 IN denotes by
T2570 5381-5387 JJ denotes severe
T2571 5388-5398 NN denotes dermatitis
T2572 5399-5400 -LRB- denotes (
T2573 5400-5404 NN denotes Fig.
T2574 5405-5407 NN denotes 1B
T2575 5407-5408 -RRB- denotes )
T2576 5408-5409 -COMMA- denotes ,
T2577 5410-5418 JJ denotes systemic
T2578 5419-5431 NN denotes inflammation
T2579 5432-5435 CC denotes and
T2580 5436-5438 DT denotes an
T2581 5439-5447 JJ denotes enlarged
T2582 5448-5454 NN denotes spleen
T2583 5455-5456 -LRB- denotes (
T2584 5456-5460 NN denotes Fig.
T2585 5461-5463 NN denotes 1C
T2586 5463-5464 -RRB- denotes )
T2587 5465-5471 VB denotes caused
T2588 5472-5474 IN denotes by
T2589 5475-5489 JJ denotes extramedullary
T2590 5490-5503 NN denotes hematopoiesis
T2591 5504-5505 -LRB- denotes [
T2592 5505-5506 CD denotes 3
T2593 5506-5507 -RRB- denotes ]
T2594 5509-5512 DT denotes The
T2595 5513-5523 JJ denotes endogenous
T2596 5524-5534 NN denotes expression
T2597 5535-5537 IN denotes of
T2598 5538-5545 NN denotes Sharpin
T2599 5546-5550 NN denotes mRNA
T2600 5551-5553 IN denotes in
T2601 5554-5558 NN denotes BMDC
T2602 5559-5562 VB denotes was
T2603 5563-5573 VB denotes determined
T2604 5574-5576 IN denotes by
T2605 5577-5589 JJ denotes quantitative
T2606 5590-5594 JJ denotes real
T2607 5595-5603 NN denotes time-PCR
T2608 5604-5605 -LRB- denotes (
T2609 5605-5612 NN denotes qRT-PCR
T2610 5612-5613 -RRB- denotes )
T2611 5614-5623 VB denotes following
T2612 5624-5631 NN denotes culture
T2613 5632-5634 IN denotes in
T2614 5635-5641 NN denotes medium
T2615 5642-5646 RB denotes only
T2616 5647-5649 CC denotes or
T2617 5650-5655 IN denotes after
T2618 5656-5667 NN denotes stimulation
T2619 5668-5672 IN denotes with
T2620 5673-5676 NN denotes LPS
T2621 5678-5685 NN denotes Sharpin
T2622 5686-5690 NN denotes mRNA
T2623 5691-5694 VB denotes was
T2624 5695-5702 JJ denotes present
T2625 5703-5705 IN denotes in
T2626 5706-5710 NN denotes BMDC
T2627 5711-5720 VB denotes generated
T2628 5721-5725 IN denotes from
T2629 5726-5728 JJ denotes WT
T2630 5729-5733 NN denotes mice
T2631 5734-5735 -LRB- denotes (
T2632 5735-5739 NNP denotes Fig.
T2633 5740-5742 NN denotes 1D
T2634 5742-5743 -RRB- denotes )
T2635 5744-5747 CC denotes and
T2636 5748-5751 PRP-DOLLAR- denotes its
T2637 5752-5757 NN denotes level
T2638 5758-5761 VB denotes was
T2639 5762-5770 RB denotes modestly
T2640 5771-5780 VB denotes decreased
T2641 5781-5783 IN denotes by
T2642 5784-5787 NN denotes LPS
T2643 5788-5799 NN denotes stimulation
T2644 5801-5806 EX denotes There
T2645 5807-5810 VB denotes was
T2646 5811-5812 DT denotes a
T2647 5813-5824 JJ denotes significant
T2648 5825-5834 NN denotes reduction
T2649 5835-5837 IN denotes of
T2650 5838-5845 NN denotes Sharpin
T2651 5846-5850 NN denotes mRNA
T2652 5851-5852 -LRB- denotes (
T2653 5852-5860 JJ denotes 6–7-fold
T2654 5860-5861 -RRB- denotes )
T2655 5862-5864 IN denotes in
T2656 5865-5869 NN denotes BMDC
T2657 5870-5879 VB denotes generated
T2658 5880-5884 IN denotes from
T2659 5885-5889 NN denotes cpdm
T2660 5890-5894 NN denotes mice
T2661 5896-5908 NN denotes Transfection
T2662 5909-5911 IN denotes of
T2663 5912-5923 JJ denotes Flag-tagged
T2664 5924-5931 NNP denotes Sharpin
T2665 5932-5934 IN denotes in
T2666 5935-5946 NN denotes fibroblasts
T2667 5947-5948 -LRB- denotes (
T2668 5948-5954 NN denotes NIH3T3
T2669 5954-5955 -RRB- denotes )
T2670 5956-5959 CC denotes and
T2671 5960-5971 NN denotes macrophages
T2672 5972-5973 -LRB- denotes (
T2673 5973-5981 NN denotes RAW264.7
T2674 5981-5982 -RRB- denotes )
T2675 5983-5992 VB denotes indicated
T2676 5993-6004 JJ denotes cytoplasmic
T2677 6005-6017 NN denotes localization
T2678 6018-6020 IN denotes of
T2679 6021-6024 DT denotes the
T2680 6025-6032 NN denotes SHARPIN
T2681 6033-6040 NN denotes protein
T2682 6041-6042 -LRB- denotes (
T2683 6042-6046 NN denotes Fig.
T2684 6047-6049 NN denotes 1E
T2685 6049-6050 -RRB- denotes )
T12991 6096-6098 FW denotes In
T12992 6099-6103 FW denotes vivo
T12993 6104-6107 CC denotes and
T12994 6108-6110 FW denotes in
T12995 6111-6116 FW denotes vitro
T12996 6117-6125 NN denotes features
T12997 6126-6128 IN denotes of
T12998 6129-6136 NN denotes SHARPIN
T12999 6138-6139 -LRB- denotes (
T13000 6139-6140 NN denotes A
T13001 6140-6141 -RRB- denotes )
T13002 6142-6147 NN denotes COILS
T13003 6148-6151 CC denotes and
T13004 6152-6161 NNP denotes MotifScan
T13005 6162-6170 NN denotes programs
T13006 6171-6175 VB denotes were
T13007 6176-6180 VB denotes used
T13008 6181-6183 TO denotes to
T13009 6184-6191 VB denotes predict
T13010 6192-6195 DT denotes the
T13011 6196-6204 NN denotes presence
T13012 6205-6207 IN denotes of
T13013 6208-6210 NN denotes CC
T13014 6211-6212 -LRB- denotes (
T13015 6212-6223 NN denotes coiled-coil
T13016 6223-6224 -RRB- denotes )
T13017 6225-6231 NN denotes domain
T13018 6231-6232 -COMMA- denotes ,
T13019 6233-6236 NN denotes UBL
T13020 6237-6238 -LRB- denotes (
T13021 6238-6252 JJ denotes ubiquitin-like
T13022 6252-6253 -RRB- denotes )
T13023 6254-6260 NN denotes domain
T13024 6261-6264 CC denotes and
T13025 6265-6270 NN denotes ZFRBP
T13026 6271-6272 -LRB- denotes (
T13027 6272-6283 NN denotes zinc-finger
T13028 6284-6295 NN denotes Ran-Binding
T13029 6296-6303 NN denotes protein
T13030 6304-6305 CD denotes 2
T13031 6305-6306 -RRB- denotes )
T13032 6307-6313 NN denotes domain
T13033 6314-6319 WDT denotes which
T13034 6320-6324 VB denotes form
T13035 6325-6332 JJ denotes similar
T13036 6333-6338 NN denotes motif
T13037 6339-6347 NN denotes patterns
T13038 6348-6350 IN denotes in
T13039 6351-6354 DT denotes the
T13040 6355-6362 NN denotes SHARPIN
T13041 6363-6370 NN denotes protein
T13042 6371-6373 IN denotes of
T13043 6374-6379 JJ denotes human
T13044 6379-6380 -COMMA- denotes ,
T13045 6381-6386 NN denotes mouse
T13046 6387-6390 CC denotes and
T13047 6391-6394 NN denotes rat
T13048 6395-6403 NN denotes origins.
T13049 6404-6405 -LRB- denotes (
T13050 6405-6406 NN denotes B
T13051 6406-6407 -RRB- denotes )
T13052 6408-6413 CD denotes Eight
T13053 6414-6422 JJ denotes week-old
T13054 6423-6430 NN denotes females
T13055 6431-6433 IN denotes of
T13056 6434-6436 NN denotes WT
T13057 6437-6440 CC denotes and
T13058 6441-6445 NN denotes cpdm
T13059 6446-6450 NN denotes mice
T13060 6452-6455 DT denotes The
T13061 6456-6462 JJ denotes mutant
T13062 6463-6467 NN denotes mice
T13063 6468-6469 -LRB- denotes (
T13064 6469-6474 IN denotes above
T13065 6474-6475 -RRB- denotes )
T13066 6476-6483 VB denotes develop
T13067 6484-6495 JJ denotes progressive
T13068 6496-6500 NN denotes skin
T13069 6501-6513 NN denotes inflammation
T13070 6514-6522 VB denotes starting
T13071 6523-6525 IN denotes at
T13072 6526-6531 IN denotes about
T13073 6532-6536 CD denotes four
T13074 6537-6543 NN denotes weeks.
T13075 6544-6545 -LRB- denotes (
T13076 6545-6546 NN denotes C
T13077 6546-6547 -RRB- denotes )
T13078 6548-6562 JJ denotes Extramedullary
T13079 6563-6576 NN denotes hematopoiesis
T13080 6577-6583 VB denotes causes
T13081 6584-6590 JJ denotes marked
T13082 6591-6602 NN denotes enlargement
T13083 6603-6605 IN denotes of
T13084 6606-6609 DT denotes the
T13085 6610-6616 NN denotes spleen
T13086 6617-6619 IN denotes of
T13087 6620-6624 NN denotes cpdm
T13088 6625-6630 NN denotes mice.
T13089 6631-6632 -LRB- denotes (
T13090 6632-6633 NN denotes D
T13091 6633-6634 -RRB- denotes )
T13092 6635-6639 NN denotes BMDC
T13093 6640-6644 VB denotes were
T13094 6645-6654 VB denotes incubated
T13095 6655-6657 IN denotes in
T13096 6658-6661 DT denotes the
T13097 6662-6669 NN denotes absence
T13098 6670-6672 CC denotes or
T13099 6673-6681 NN denotes presence
T13100 6682-6684 IN denotes of
T13101 6685-6688 CD denotes 100
T13102 6689-6694 NN denotes ng/ml
T13103 6695-6698 NN denotes LPS
T13104 6699-6702 IN denotes for
T13105 6703-6704 CD denotes 4
T13106 6705-6710 NN denotes hours
T13107 6712-6715 DT denotes The
T13108 6716-6720 NN denotes mRNA
T13109 6721-6726 NN denotes level
T13110 6727-6729 IN denotes of
T13111 6730-6737 NN denotes Sharpin
T13112 6738-6741 VB denotes was
T13113 6742-6750 VB denotes measured
T13114 6751-6753 IN denotes by
T13115 6754-6761 NN denotes qRT-PCR
T13116 6762-6765 CC denotes and
T13117 6766-6775 VB denotes presented
T13118 6776-6784 JJ denotes relative
T13119 6785-6787 TO denotes to
T13120 6788-6791 DT denotes the
T13121 6792-6796 NN denotes mRNA
T13122 6797-6807 NN denotes expression
T13123 6808-6810 IN denotes in
T13124 6811-6825 JJ denotes non-stimulated
T13125 6826-6828 NNP denotes WT
T13126 6829-6833 NN denotes BMDC
T13127 6835-6839 NN denotes Bars
T13128 6840-6849 VB denotes represent
T13129 6850-6853 DT denotes the
T13130 6854-6858 JJ denotes mean
T13131 6859-6860 JJ denotes ±
T13132 6861-6865 NN denotes s.d.
T13133 6866-6868 IN denotes of
T13134 6869-6870 CD denotes 3
T13135 6871-6876 NN denotes mice.
T13136 6877-6878 SYM denotes *
T13137 6879-6880 NN denotes P
T13138 6880-6881 SYM denotes <
T13139 6881-6885 CD denotes 0.05
T13140 6885-6886 -COLON- denotes ;
T13141 6887-6889 SYM denotes **
T13142 6890-6891 NN denotes P
T13143 6891-6892 SYM denotes <
T13144 6892-6898 CD denotes 0.001.
T13145 6899-6900 -LRB- denotes (
T13146 6900-6901 NN denotes E
T13147 6901-6902 -RRB- denotes )
T13148 6903-6913 NN denotes Fibroblast
T13149 6914-6915 -LRB- denotes (
T13150 6915-6921 NN denotes NIH3T3
T13151 6921-6922 -RRB- denotes )
T13152 6923-6926 CC denotes and
T13153 6927-6938 NN denotes macrophages
T13154 6939-6940 -LRB- denotes (
T13155 6940-6948 NN denotes RAW264.7
T13156 6948-6949 -RRB- denotes )
T13157 6950-6955 NN denotes cells
T13158 6956-6960 VB denotes were
T13159 6961-6972 VB denotes transfected
T13160 6973-6977 IN denotes with
T13161 6978-6981 DT denotes the
T13162 6982-6992 NN denotes expression
T13163 6993-7000 NN denotes plasmid
T13164 7001-7014 NN denotes pFLAG-SHARPIN
T13165 7016-7021 IN denotes After
T13166 7022-7024 CD denotes 48
T13167 7025-7030 NN denotes hours
T13168 7030-7031 -COMMA- denotes ,
T13169 7032-7037 NN denotes cells
T13170 7038-7042 VB denotes were
T13171 7043-7048 VB denotes fixed
T13172 7049-7052 CC denotes and
T13173 7053-7059 VB denotes probed
T13174 7060-7064 IN denotes with
T13175 7065-7074 JJ denotes anti-FLAG
T13176 7075-7078 CC denotes and
T13177 7079-7094 JJ denotes FITC-conjugated
T13178 7095-7104 JJ denotes secondary
T13179 7105-7113 NN denotes antibody
T13180 7115-7121 NN denotes Nuclei
T13181 7122-7126 VB denotes were
T13182 7127-7134 VB denotes stained
T13183 7135-7139 IN denotes with
T13184 7140-7144 NNP denotes DAPI
T13185 7146-7148 IN denotes In
T13186 7149-7153 DT denotes both
T13187 7154-7165 VB denotes transfected
T13188 7166-7170 NN denotes cell
T13189 7171-7176 NN denotes lines
T13190 7176-7177 -COMMA- denotes ,
T13191 7178-7190 NN denotes FLAG-SHARPIN
T13192 7191-7194 VB denotes was
T13193 7195-7200 VB denotes found
T13194 7201-7203 TO denotes to
T13195 7204-7206 VB denotes be
T13196 7207-7226 JJ denotes cytoplasm-localized
T3281 7229-7240 NN denotes Phenotyping
T3282 7241-7248 JJ denotes splenic
T3283 7249-7251 NN denotes DC
T3284 7252-7255 CC denotes and
T3285 7256-7260 NN denotes BMDC
T3286 7261-7265 IN denotes from
T3287 7266-7268 NN denotes WT
T3288 7269-7272 CC denotes and
T3289 7273-7277 NN denotes cpdm
T3290 7278-7282 NN denotes mice
T3291 7283-7285 NN denotes DC
T3292 7286-7289 VB denotes are
T3293 7290-7303 JJ denotes heterogeneous
T3294 7304-7307 CC denotes and
T3295 7308-7311 MD denotes can
T3296 7312-7314 VB denotes be
T3297 7315-7326 VB denotes categorized
T3298 7327-7331 IN denotes into
T3299 7332-7340 JJ denotes multiple
T3300 7341-7349 NN denotes subtypes
T3301 7350-7355 VB denotes based
T3302 7356-7358 IN denotes on
T3303 7359-7366 NN denotes surface
T3304 7367-7374 NN denotes markers
T3305 7375-7376 -LRB- denotes [
T3306 7376-7378 CD denotes 13
T3307 7378-7379 -RRB- denotes ]
T3308 7381-7383 TO denotes To
T3309 7384-7393 VB denotes determine
T3310 7394-7396 IN denotes if
T3311 7397-7400 DT denotes the
T3312 7401-7408 NNP denotes Sharpin
T3313 7409-7417 NN denotes mutation
T3314 7418-7425 VB denotes affects
T3315 7426-7428 NN denotes DC
T3316 7429-7440 NN denotes development
T3317 7441-7443 IN denotes in
T3318 7444-7452 JJ denotes lymphoid
T3319 7453-7460 NN denotes tissues
T3320 7460-7461 -COMMA- denotes ,
T3321 7462-7467 NN denotes mouse
T3322 7468-7475 NN denotes spleens
T3323 7476-7480 VB denotes were
T3324 7481-7489 VB denotes examined
T3325 7490-7493 IN denotes for
T3326 7494-7497 DT denotes the
T3327 7498-7510 NN denotes distribution
T3328 7511-7513 IN denotes of
T3329 7514-7526 JJ denotes conventional
T3330 7527-7529 NN denotes DC
T3331 7530-7531 -LRB- denotes (
T3332 7531-7534 NN denotes cDC
T3333 7534-7535 -COLON- denotes ;
T3334 7536-7547 JJ denotes CD11c+CD8α+
T3335 7548-7551 CC denotes and
T3336 7552-7563 NN denotes CD11c+CD8α−
T3337 7563-7564 -RRB- denotes )
T3338 7565-7566 -LRB- denotes [
T3339 7566-7568 CD denotes 13
T3340 7568-7569 -RRB- denotes ]
T3341 7570-7573 CC denotes and
T3342 7574-7586 JJ denotes plasmacytoid
T3343 7587-7589 NN denotes DC
T3344 7590-7591 -LRB- denotes (
T3345 7591-7594 NN denotes pDC
T3346 7594-7595 -COLON- denotes ;
T3347 7596-7609 JJ denotes CD11c−PDCA-1+
T3348 7609-7610 -RRB- denotes )
T3349 7611-7612 -LRB- denotes [
T3350 7612-7614 CD denotes 14
T3351 7614-7615 -RRB- denotes ]
T3352 7617-7620 DT denotes The
T3353 7621-7632 NN denotes percentages
T3354 7633-7636 IN denotes for
T3355 7637-7644 JJ denotes splenic
T3356 7645-7648 NN denotes cDC
T3357 7649-7652 CC denotes and
T3358 7653-7656 NN denotes pDC
T3359 7657-7661 VB denotes were
T3360 7662-7666 DT denotes both
T3361 7667-7674 VB denotes reduced
T3362 7675-7677 IN denotes in
T3363 7678-7682 NN denotes cpdm
T3364 7683-7687 NN denotes mice
T3365 7688-7692 WRB denotes when
T3366 7693-7701 VB denotes compared
T3367 7702-7706 IN denotes with
T3368 7707-7709 JJ denotes WT
T3369 7710-7718 NN denotes controls
T3370 7719-7720 -LRB- denotes (
T3371 7720-7724 NNP denotes Fig.
T3372 7725-7727 NN denotes 2A
T3373 7727-7728 -RRB- denotes )
T3374 7730-7737 RB denotes However
T3375 7737-7738 -COMMA- denotes ,
T3376 7739-7743 WRB denotes when
T3377 7744-7749 VB denotes gated
T3378 7750-7752 IN denotes on
T3379 7753-7759 JJ denotes CD11c+
T3380 7760-7763 NN denotes cDC
T3381 7763-7764 -COMMA- denotes ,
T3382 7765-7768 DT denotes the
T3383 7769-7780 NN denotes percentages
T3384 7781-7783 IN denotes of
T3385 7784-7789 JJ denotes CD8α+
T3386 7790-7793 CC denotes and
T3387 7794-7799 NN denotes CD8α−
T3388 7800-7805 NN denotes cells
T3389 7806-7810 VB denotes were
T3390 7811-7814 RB denotes not
T3391 7815-7823 VB denotes affected
T3392 7824-7826 IN denotes by
T3393 7827-7834 NN denotes SHARPIN
T3394 7835-7845 NN denotes deficiency
T3395 7846-7847 -LRB- denotes (
T3396 7847-7851 NN denotes Fig.
T3397 7852-7854 NN denotes 2A
T3398 7854-7855 -RRB- denotes )
T3399 7857-7862 IN denotes Since
T3400 7863-7866 DT denotes the
T3401 7867-7873 NN denotes spleen
T3402 7874-7876 IN denotes of
T3403 7877-7881 NN denotes cpdm
T3404 7882-7886 NN denotes mice
T3405 7887-7889 VB denotes is
T3406 7890-7898 RB denotes markedly
T3407 7899-7907 VB denotes enlarged
T3408 7908-7911 CC denotes and
T3409 7912-7920 VB denotes contains
T3410 7921-7926 CD denotes three
T3411 7927-7932 NN denotes times
T3412 7933-7935 IN denotes as
T3413 7936-7940 JJ denotes many
T3414 7941-7946 NN denotes cells
T3415 7947-7948 -LRB- denotes (
T3416 7948-7952 NN denotes Fig.
T3417 7953-7955 NN denotes 1C
T3418 7955-7956 -RRB- denotes )
T3419 7956-7957 -COMMA- denotes ,
T3420 7958-7961 DT denotes the
T3421 7962-7971 JJ denotes different
T3422 7972-7983 NN denotes percentages
T3423 7984-7986 IN denotes of
T3424 7987-7994 JJ denotes splenic
T3425 7995-7998 NN denotes cDC
T3426 7999-8002 CC denotes and
T3427 8003-8006 NN denotes pDC
T3428 8007-8014 IN denotes between
T3429 8015-8017 NN denotes WT
T3430 8018-8021 CC denotes and
T3431 8022-8028 JJ denotes mutant
T3432 8029-8033 NN denotes mice
T3433 8034-8041 VB denotes reflect
T3434 8042-8045 DT denotes the
T3435 8046-8055 VB denotes increased
T3436 8056-8062 NN denotes number
T3437 8063-8065 IN denotes of
T3438 8066-8071 JJ denotes total
T3439 8072-8078 NN denotes spleen
T3440 8079-8084 NN denotes cells
T3441 8085-8091 RB denotes rather
T3442 8092-8096 IN denotes than
T3443 8097-8098 DT denotes a
T3444 8099-8108 NN denotes reduction
T3445 8109-8111 IN denotes in
T3446 8112-8115 NN denotes cDC
T3447 8116-8119 CC denotes and
T3448 8120-8123 NN denotes pDC
T3449 8124-8131 NN denotes numbers
T3450 8133-8138 DT denotes These
T3451 8139-8143 NN denotes data
T3452 8144-8152 VB denotes indicate
T3453 8153-8157 IN denotes that
T3454 8158-8161 DT denotes the
T3455 8162-8169 NNP denotes Sharpin
T3456 8170-8178 NN denotes mutation
T3457 8179-8183 VB denotes does
T3458 8184-8187 RB denotes not
T3459 8188-8194 VB denotes affect
T3460 8195-8198 DT denotes the
T3461 8199-8211 NN denotes distribution
T3462 8212-8214 IN denotes of
T3463 8215-8218 DT denotes the
T3464 8219-8227 VB denotes examined
T3465 8228-8230 NN denotes DC
T3466 8231-8238 NN denotes subsets
T3467 8239-8241 IN denotes in
T3468 8242-8245 DT denotes the
T3469 8246-8252 NN denotes spleen
T13537 8298-8304 NN denotes Effect
T13538 8305-8307 IN denotes of
T13539 8308-8315 NNP denotes Sharpin
T13540 8316-8324 NN denotes mutation
T13541 8325-8327 IN denotes on
T13542 8328-8330 NN denotes DC
T13543 8331-8345 NN denotes subpopulations
T13544 8346-8349 CC denotes and
T13545 8350-8360 NN denotes maturation
T13546 8362-8363 -LRB- denotes (
T13547 8363-8364 NN denotes A
T13548 8364-8365 -RRB- denotes )
T13549 8366-8373 NN denotes Spleens
T13550 8374-8378 IN denotes from
T13551 8379-8381 NN denotes WT
T13552 8382-8385 CC denotes and
T13553 8386-8390 NN denotes cpdm
T13554 8391-8395 NN denotes mice
T13555 8396-8400 VB denotes were
T13556 8401-8409 VB denotes isolated
T13557 8410-8413 CC denotes and
T13558 8414-8421 JJ denotes subject
T13559 8422-8424 TO denotes to
T13560 8425-8436 NN denotes collagenase
T13561 8437-8440 CC denotes and
T13562 8441-8446 NN denotes DNase
T13563 8447-8456 NN denotes digestion
T13564 8458-8461 DT denotes The
T13565 8462-8470 VB denotes obtained
T13566 8471-8478 JJ denotes splenic
T13567 8479-8490 NN denotes homogenates
T13568 8491-8495 VB denotes were
T13569 8496-8507 VB denotes centrifuged
T13570 8508-8512 IN denotes over
T13571 8513-8514 DT denotes a
T13572 8515-8522 NN denotes Percoll
T13573 8523-8531 NN denotes gradient
T13574 8532-8533 -LRB- denotes (
T13575 8533-8535 CD denotes 35
T13576 8535-8536 NN denotes %
T13577 8537-8540 CC denotes and
T13578 8541-8543 CD denotes 55
T13579 8543-8544 NN denotes %
T13580 8545-8552 NN denotes density
T13581 8552-8553 -RRB- denotes )
T13582 8554-8557 IN denotes for
T13583 8558-8560 CD denotes 15
T13584 8561-8568 NN denotes minutes
T13585 8570-8573 DT denotes The
T13586 8574-8579 NN denotes bands
T13587 8580-8582 IN denotes at
T13588 8583-8586 DT denotes the
T13589 8587-8589 CD denotes 35
T13590 8589-8590 NN denotes %
T13591 8590-8597 NN denotes -medium
T13592 8598-8601 CC denotes and
T13593 8602-8605 DT denotes the
T13594 8606-8611 CD denotes 35–55
T13595 8611-8612 NN denotes %
T13596 8613-8622 NN denotes interface
T13597 8623-8627 VB denotes were
T13598 8628-8634 VB denotes pooled
T13599 8634-8635 -COMMA- denotes ,
T13600 8636-8642 VB denotes washed
T13601 8643-8646 CC denotes and
T13602 8647-8654 VB denotes stained
T13603 8655-8659 IN denotes with
T13604 8660-8661 DT denotes a
T13605 8662-8673 NN denotes combination
T13606 8674-8676 IN denotes of
T13607 8677-8684 JJ denotes various
T13608 8685-8695 NN denotes antibodies
T13609 8696-8698 TO denotes to
T13610 8699-8704 VB denotes stain
T13611 8705-8714 JJ denotes different
T13612 8715-8717 NN denotes DC
T13613 8718-8725 NN denotes subsets
T13614 8725-8726 -COMMA- denotes ,
T13615 8727-8739 JJ denotes conventional
T13616 8740-8751 NN denotes CD11c+CD8α+
T13617 8751-8752 -COMMA- denotes ,
T13618 8753-8764 NN denotes CD11c+CD8α−
T13619 8765-8768 CC denotes and
T13620 8769-8781 JJ denotes plasmacytoid
T13621 8782-8784 NN denotes DC
T13622 8785-8786 -LRB- denotes (
T13623 8786-8799 JJ denotes CD11c−PDCA-1+
T13624 8799-8800 -RRB- denotes )
T13625 8800-8804 NN denotes .The
T13626 8805-8808 JJ denotes top
T13627 8809-8815 NN denotes panels
T13628 8816-8820 VB denotes were
T13629 8821-8826 VB denotes gated
T13630 8827-8829 IN denotes on
T13631 8830-8840 NN denotes FSChiSSClo
T13632 8841-8846 NN denotes cells
T13633 8847-8849 TO denotes to
T13634 8850-8854 VB denotes show
T13635 8855-8863 JJ denotes separate
T13636 8864-8875 NN denotes populations
T13637 8876-8878 IN denotes of
T13638 8879-8892 JJ denotes CD11c+PDCA-1−
T13639 8893-8896 CC denotes and
T13640 8897-8910 JJ denotes CD11c−PDCA-1+
T13641 8911-8916 NN denotes cells
T13642 8918-8925 RB denotes Further
T13643 8926-8932 VB denotes gating
T13644 8933-8935 IN denotes on
T13645 8936-8939 DT denotes the
T13646 8940-8953 JJ denotes CD11c+PDCA-1−
T13647 8954-8967 NN denotes subpopulation
T13648 8968-8972 VB denotes gave
T13649 8973-8976 DT denotes the
T13650 8977-8983 NN denotes bottom
T13651 8984-8989 NN denotes panel
T13652 8990-8994 WDT denotes that
T13653 8995-9001 VB denotes showed
T13654 9002-9005 CD denotes two
T13655 9006-9014 JJ denotes distinct
T13656 9015-9020 NN denotes pools
T13657 9021-9023 IN denotes of
T13658 9024-9035 JJ denotes CD11c+CD8α+
T13659 9036-9039 CC denotes and
T13660 9040-9051 NN denotes CD11c+CD8α−
T13661 9052-9057 NN denotes cells
T13662 9059-9070 NN denotes Percentages
T13663 9071-9075 VB denotes were
T13664 9076-9086 VB denotes calculated
T13665 9087-9092 VB denotes based
T13666 9093-9095 IN denotes on
T13667 9096-9099 DT denotes the
T13668 9100-9108 JJ denotes parental
T13669 9109-9119 NN denotes population
T13670 9120-9123 CC denotes and
T13671 9124-9128 VB denotes were
T13672 9129-9141 RB denotes additionally
T13673 9142-9147 VB denotes shown
T13674 9148-9150 IN denotes as
T13675 9151-9154 NN denotes bar
T13676 9155-9161 NN denotes graphs
T13677 9162-9163 -LRB- denotes (
T13678 9163-9168 NN denotes n = 2
T13679 9168-9169 -RRB- denotes )
T13680 9170-9171 -LRB- denotes (
T13681 9171-9172 NN denotes B
T13682 9172-9173 -RRB- denotes )
T13683 9173-9174 -LRB- denotes .
T13684 9175-9176 NN denotes (
T13685 9176-9177 -RRB- denotes C
T13686 9177-9179 NN denotes )
T13687 9179-9182 CC denotes WT
T13688 9182-9186 NN denotes and
T13689 9186-9190 NN denotes cpdm
T13690 9191-9192 -LRB- denotes B
T13691 9192-9197 CD denotes MDC (
T13692 9197-9198 -RRB- denotes 5
T13693 9198-9203 NN denotes ×105)
T13694 9204-9208 VB denotes cell
T13695 9208-9218 VB denotes s were sti
T13696 9218-9222 IN denotes mula
T13697 9222-9228 NN denotes ted wi
T13698 9228-9229 -COMMA- denotes t
T13699 9229-9232 CD denotes h m
T13700 9232-9237 NN denotes edium
T13701 9237-9240 NN denotes , 1
T13702 9240-9242 CC denotes 00
T13703 9243-9245 CD denotes ng
T13704 9245-9250 NN denotes /ml L
T13705 9250-9254 NN denotes PS o
T13706 9254-9255 NN denotes r
T13707 9256-9257 -COLON- denotes 2
T13708 9257-9258 NN denotes 5
T13709 9259-9262 IN denotes µg/
T13710 9262-9264 CD denotes ml
T13711 9265-9270 NN denotes poly
T13712 9288-9291 DT denotes The
T13713 9292-9297 NN denotes cells
T13714 9298-9302 VB denotes were
T13715 9303-9310 VB denotes labeled
T13716 9311-9315 IN denotes with
T13717 9316-9326 JJ denotes PE-labeled
T13718 9327-9336 NN denotes anti-CD40
T13719 9336-9337 -COMMA- denotes ,
T13720 9338-9347 NN denotes anti-CD80
T13721 9347-9348 -COMMA- denotes ,
T13722 9349-9352 CC denotes and
T13723 9353-9362 NN denotes anti-CD86
T13724 9362-9363 -COMMA- denotes ,
T13725 9364-9367 CC denotes and
T13726 9368-9377 VB denotes subjected
T13727 9378-9380 TO denotes to
T13728 9381-9385 VB denotes flow
T13729 9386-9395 NN denotes cytometry
T13730 9396-9404 NN denotes analysis
T13731 9406-9409 DT denotes The
T13732 9410-9421 NN denotes populations
T13733 9422-9427 VB denotes shown
T13734 9428-9430 IN denotes in
T13735 9431-9441 NN denotes histograms
T13736 9442-9446 VB denotes were
T13737 9447-9452 VB denotes gated
T13738 9453-9455 IN denotes on
T13739 9456-9462 JJ denotes CD11c+
T13740 9463-9468 NN denotes cells
T13741 9470-9479 JJ denotes Unstained
T13742 9480-9485 NN denotes cells
T13743 9486-9492 VB denotes served
T13744 9493-9495 IN denotes as
T13745 9496-9504 JJ denotes negative
T13746 9505-9513 NN denotes controls
T13747 9515-9522 NN denotes Results
T13748 9523-9526 VB denotes are
T13749 9527-9541 JJ denotes representative
T13750 9542-9544 IN denotes of
T13751 9545-9548 CD denotes two
T13752 9549-9560 JJ denotes independent
T13753 9561-9572 NN denotes experiments
T3470 9576-9580 NN denotes BMDC
T3471 9581-9585 IN denotes from
T3472 9586-9588 FW denotes in
T3473 9589-9594 FW denotes vitro
T3474 9595-9603 NN denotes cultures
T3475 9604-9616 RB denotes functionally
T3476 9617-9625 VB denotes resemble
T3477 9626-9638 JJ denotes non-lymphoid
T3478 9639-9645 NN denotes tissue
T3479 9646-9648 NN denotes DC
T3480 9649-9652 CC denotes and
T3481 9653-9669 JJ denotes monocyte-derived
T3482 9670-9682 JJ denotes inflammatory
T3483 9683-9685 NN denotes DC
T3484 9686-9687 -LRB- denotes [
T3485 9687-9689 CD denotes 15
T3486 9689-9690 -RRB- denotes ]
T3487 9690-9691 -COMMA- denotes ,
T3488 9692-9693 -LRB- denotes [
T3489 9693-9695 CD denotes 16
T3490 9695-9696 -RRB- denotes ]
T3491 9698-9701 DT denotes The
T3492 9702-9708 NN denotes yields
T3493 9709-9711 IN denotes of
T3494 9712-9716 NN denotes BMDC
T3495 9717-9721 IN denotes from
T3496 9722-9724 NN denotes WT
T3497 9725-9728 CC denotes and
T3498 9729-9733 NN denotes cpdm
T3499 9734-9738 NN denotes mice
T3500 9739-9743 VB denotes were
T3501 9744-9751 JJ denotes similar
T3502 9753-9757 NN denotes BMDC
T3503 9758-9762 VB denotes were
T3504 9763-9769 JJ denotes CD11c+
T3505 9770-9773 CC denotes and
T3506 9774-9777 NN denotes MHC
T3507 9778-9781 JJ denotes II+
T3508 9782-9786 IN denotes with
T3509 9787-9790 JJ denotes low
T3510 9791-9801 NN denotes expression
T3511 9802-9804 IN denotes of
T3512 9805-9819 JJ denotes co-stimulatory
T3513 9820-9829 NN denotes molecules
T3514 9830-9834 NN denotes CD40
T3515 9834-9835 -COMMA- denotes ,
T3516 9836-9840 NN denotes CD80
T3517 9840-9841 -COMMA- denotes ,
T3518 9842-9845 CC denotes and
T3519 9846-9850 NN denotes CD86
T3520 9852-9855 DT denotes The
T3521 9856-9860 NN denotes TLR3
T3522 9861-9867 NN denotes ligand
T3523 9868-9872 NN denotes poly
T3524 9873-9874 NN denotes I
T3525 9874-9875 -COLON- denotes :
T3526 9875-9876 NN denotes C
T3527 9877-9880 CC denotes and
T3528 9881-9884 DT denotes the
T3529 9885-9889 NN denotes TLR4
T3530 9890-9896 NN denotes ligand
T3531 9897-9900 NN denotes LPS
T3532 9901-9905 DT denotes each
T3533 9906-9914 VB denotes activate
T3534 9915-9926 VB denotes overlapping
T3535 9927-9930 CC denotes but
T3536 9931-9940 JJ denotes different
T3537 9941-9950 NN denotes signaling
T3538 9951-9959 NN denotes pathways
T3539 9960-9963 CC denotes and
T3540 9964-9968 VB denotes were
T3541 9969-9973 VB denotes used
T3542 9974-9976 TO denotes to
T3543 9977-9983 VB denotes induce
T3544 9984-9986 NN denotes DC
T3545 9987-9997 NN denotes maturation
T3546 9998-9999 -LRB- denotes [
T3547 9999-10001 CD denotes 17
T3548 10001-10002 -RRB- denotes ]
T3549 10002-10003 -COMMA- denotes ,
T3550 10004-10005 -LRB- denotes [
T3551 10005-10007 CD denotes 18
T3552 10007-10008 -RRB- denotes ]
T3553 10010-10020 NN denotes Incubation
T3554 10021-10025 IN denotes with
T3555 10026-10029 DT denotes the
T3556 10030-10033 NN denotes TLR
T3557 10034-10042 NN denotes agonists
T3558 10043-10046 IN denotes for
T3559 10047-10049 CD denotes 24
T3560 10050-10055 NN denotes hours
T3561 10056-10064 VB denotes resulted
T3562 10065-10067 IN denotes in
T3563 10068-10077 VB denotes increased
T3564 10078-10088 NN denotes expression
T3565 10089-10091 IN denotes of
T3566 10092-10096 NN denotes CD40
T3567 10096-10097 -COMMA- denotes ,
T3568 10098-10102 NN denotes CD80
T3569 10102-10103 -COMMA- denotes ,
T3570 10104-10107 CC denotes and
T3571 10108-10112 NN denotes CD86
T3572 10113-10115 IN denotes on
T3573 10116-10120 NN denotes BMDC
T3574 10120-10121 -COLON- denotes ;
T3575 10122-10129 RB denotes however
T3576 10129-10130 -COMMA- denotes ,
T3577 10131-10136 EX denotes there
T3578 10137-10140 VB denotes was
T3579 10141-10143 DT denotes no
T3580 10144-10154 NN denotes difference
T3581 10155-10157 IN denotes in
T3582 10158-10161 DT denotes the
T3583 10162-10172 NN denotes expression
T3584 10173-10179 NN denotes levels
T3585 10180-10182 IN denotes of
T3586 10183-10188 DT denotes these
T3587 10189-10196 NN denotes markers
T3588 10197-10204 IN denotes between
T3589 10205-10207 NN denotes WT
T3590 10208-10211 CC denotes and
T3591 10212-10216 NN denotes cpdm
T3592 10217-10221 NN denotes BMDC
T3593 10222-10223 -LRB- denotes (
T3594 10223-10227 NN denotes Fig.
T3595 10228-10230 NN denotes 2B
T3596 10230-10231 -RRB- denotes )
T3597 10233-10237 RB denotes Thus
T3598 10237-10238 -COMMA- denotes ,
T3599 10239-10246 NN denotes SHARPIN
T3600 10247-10257 NN denotes deficiency
T3601 10258-10261 VB denotes did
T3602 10262-10265 RB denotes not
T3603 10266-10275 VB denotes influence
T3604 10276-10279 DT denotes the
T3605 10280-10290 NN denotes expression
T3606 10291-10293 IN denotes of
T3607 10294-10308 JJ denotes co-stimulatory
T3608 10309-10318 NN denotes molecules
T3609 10319-10321 IN denotes by
T3610 10322-10326 NN denotes BMDC
T4014 10329-10339 NN denotes Production
T4015 10340-10342 IN denotes of
T4016 10343-10358 JJ denotes proinflammatory
T4017 10359-10368 NN denotes mediators
T4018 10369-10371 IN denotes by
T4019 10372-10376 NN denotes cpdm
T4020 10377-10381 NN denotes BMDC
T4021 10382-10384 VB denotes is
T4022 10385-10393 VB denotes impaired
T4023 10394-10404 NN denotes Incubation
T4024 10405-10409 IN denotes with
T4025 10410-10413 NN denotes LPS
T4026 10414-10416 CC denotes or
T4027 10417-10421 NN denotes poly
T4028 10422-10423 NN denotes I
T4029 10423-10424 SYM denotes :
T4030 10424-10425 NN denotes C
T4031 10426-10434 VB denotes resulted
T4032 10435-10437 IN denotes in
T4033 10438-10447 NN denotes secretion
T4034 10448-10450 IN denotes of
T4035 10451-10454 NN denotes IL6
T4036 10454-10455 -COMMA- denotes ,
T4037 10456-10463 NN denotes IL12P70
T4038 10463-10464 -COMMA- denotes ,
T4039 10465-10468 CC denotes and
T4040 10469-10474 NN denotes GMCSF
T4041 10475-10479 IN denotes from
T4042 10480-10484 CC denotes both
T4043 10485-10487 NN denotes WT
T4044 10488-10491 CC denotes and
T4045 10492-10496 NN denotes cpdm
T4046 10497-10501 NN denotes BMDC
T4047 10501-10502 -COLON- denotes ;
T4048 10503-10510 RB denotes however
T4049 10510-10511 -COMMA- denotes ,
T4050 10512-10516 NN denotes BMDC
T4051 10517-10521 IN denotes from
T4052 10522-10526 NN denotes cpdm
T4053 10527-10531 NN denotes mice
T4054 10532-10540 VB denotes produced
T4055 10541-10554 RB denotes significantly
T4056 10555-10559 JJ denotes less
T4057 10560-10562 IN denotes of
T4058 10563-10566 DT denotes all
T4059 10567-10572 CD denotes three
T4060 10573-10582 NN denotes cytokines
T4061 10583-10591 VB denotes compared
T4062 10592-10596 IN denotes with
T4063 10597-10599 JJ denotes WT
T4064 10600-10604 NN denotes BMDC
T4065 10605-10606 -LRB- denotes (
T4066 10606-10610 NNP denotes Fig.
T4067 10611-10615 NN denotes 3A–C
T4068 10615-10616 -COMMA- denotes ,
T4069 10617-10620 NN denotes E–F
T4070 10620-10621 -RRB- denotes )
T4071 10623-10626 DT denotes The
T4072 10627-10633 NN denotes amount
T4073 10634-10636 IN denotes of
T4074 10637-10643 JJ denotes nitric
T4075 10644-10649 NN denotes oxide
T4076 10650-10659 VB denotes generated
T4077 10660-10662 IN denotes by
T4078 10663-10669 JJ denotes mutant
T4079 10670-10674 NN denotes BMDC
T4080 10675-10678 VB denotes was
T4081 10679-10683 RB denotes also
T4082 10684-10697 RB denotes significantly
T4083 10698-10705 VB denotes reduced
T4084 10706-10714 VB denotes compared
T4085 10715-10719 IN denotes with
T4086 10720-10722 JJ denotes WT
T4087 10723-10728 NN denotes cells
T4088 10729-10730 -LRB- denotes (
T4089 10730-10734 NN denotes Fig.
T4090 10735-10737 NN denotes 3D
T4091 10737-10738 -RRB- denotes )
T4092 10738-10739 -COMMA- denotes ,
T4093 10740-10750 VB denotes indicating
T4094 10751-10759 RB denotes severely
T4095 10760-10769 VB denotes disrupted
T4096 10770-10780 NN denotes production
T4097 10781-10783 IN denotes of
T4098 10784-10799 JJ denotes proinflammatory
T4099 10800-10809 NN denotes mediators
T4100 10810-10814 IN denotes from
T4101 10815-10832 JJ denotes Sharpin-deficient
T4102 10833-10837 NN denotes BMDC
T4103 10839-10841 FW denotes In
T4104 10842-10846 FW denotes vivo
T4105 10847-10862 NN denotes complementation
T4106 10863-10867 IN denotes with
T4107 10868-10869 DT denotes a
T4108 10870-10877 NNP denotes Sharpin
T4109 10878-10893 JJ denotes gene-containing
T4110 10894-10897 NN denotes BAC
T4111 10898-10906 VB denotes reversed
T4112 10907-10910 DT denotes the
T4113 10911-10920 NN denotes phenotype
T4114 10921-10923 IN denotes of
T4115 10924-10927 DT denotes the
T4116 10928-10934 JJ denotes mutant
T4117 10935-10939 NN denotes mice
T4118 10940-10941 -LRB- denotes [
T4119 10941-10942 CD denotes 2
T4120 10942-10943 -RRB- denotes ]
T4121 10943-10944 -COMMA- denotes ,
T4122 10945-10948 CC denotes and
T4123 10949-10953 NN denotes BMDC
T4124 10954-10963 VB denotes generated
T4125 10964-10968 IN denotes from
T4126 10969-10974 DT denotes these
T4127 10975-10982 VB denotes rescued
T4128 10983-10987 NN denotes mice
T4129 10988-10996 VB denotes secreted
T4130 10997-11010 RB denotes significantly
T4131 11011-11015 JJ denotes more
T4132 11016-11023 NN denotes IL12P70
T4133 11024-11028 IN denotes than
T4134 11029-11033 NN denotes BMDC
T4135 11034-11038 IN denotes from
T4136 11039-11043 NN denotes cpdm
T4137 11044-11048 NN denotes mice
T4138 11049-11050 -LRB- denotes (
T4139 11050-11054 NNP denotes Fig.
T4140 11055-11057 NN denotes 3G
T4141 11057-11058 -RRB- denotes )
T4142 11058-11059 -COMMA- denotes ,
T4143 11060-11070 VB denotes supporting
T4144 11071-11072 DT denotes a
T4145 11073-11082 JJ denotes necessary
T4146 11083-11087 NN denotes role
T4147 11088-11090 IN denotes of
T4148 11091-11098 NN denotes SHARPIN
T4149 11099-11102 IN denotes for
T4150 11103-11106 DT denotes the
T4151 11107-11117 NN denotes production
T4152 11118-11120 IN denotes of
T4153 11121-11128 NN denotes IL12P70
T4154 11130-11132 IN denotes In
T4155 11133-11141 NN denotes addition
T4156 11141-11142 -COMMA- denotes ,
T4157 11143-11146 DT denotes the
T4158 11147-11157 NN denotes transcript
T4159 11158-11164 NN denotes levels
T4160 11165-11167 IN denotes of
T4161 11168-11171 DT denotes the
T4162 11172-11184 JJ denotes inflammatory
T4163 11185-11194 NN denotes cytokines
T4164 11195-11198 NN denotes Il6
T4165 11198-11199 -COMMA- denotes ,
T4166 11200-11207 NN denotes Il12p40
T4167 11207-11208 -COMMA- denotes ,
T4168 11209-11214 NN denotes Gmcsf
T4169 11214-11215 -COMMA- denotes ,
T4170 11216-11219 CC denotes and
T4171 11220-11224 NN denotes Ifnb
T4172 11225-11229 VB denotes were
T4173 11230-11238 VB denotes examined
T4174 11238-11239 -COMMA- denotes ,
T4175 11240-11243 CC denotes and
T4176 11244-11249 DT denotes these
T4177 11250-11254 VB denotes were
T4178 11255-11258 DT denotes all
T4179 11259-11272 RB denotes significantly
T4180 11273-11280 VB denotes reduced
T4181 11281-11283 IN denotes in
T4182 11284-11294 VB denotes stimulated
T4183 11295-11299 NN denotes cpdm
T4184 11300-11304 NN denotes BMDC
T4185 11305-11309 WRB denotes when
T4186 11310-11318 VB denotes compared
T4187 11319-11323 IN denotes with
T4188 11324-11326 JJ denotes WT
T4189 11327-11335 NN denotes controls
T4190 11336-11337 -LRB- denotes (
T4191 11337-11341 NN denotes Fig.
T4192 11342-11343 CD denotes 4
T4193 11343-11344 -RRB- denotes )
T14018 11390-11399 JJ denotes Defective
T14019 11400-11410 NN denotes production
T14020 11411-11413 IN denotes of
T14021 11414-11430 JJ denotes pro-inflammatory
T14022 11431-11440 NN denotes mediators
T14023 11441-11445 IN denotes from
T14024 11446-11456 VB denotes stimulated
T14025 11457-11461 NN denotes cpdm
T14026 11462-11466 NN denotes BMDC
T14027 11468-11469 -LRB- denotes (
T14028 11469-11472 NN denotes A–D
T14029 11472-11473 -RRB- denotes )
T14030 11474-11482 JJ denotes Cultured
T14031 11483-11485 NN denotes WT
T14032 11486-11489 CC denotes and
T14033 11490-11494 NN denotes cpdm
T14034 11495-11499 NN denotes BMDC
T14035 11500-11501 -LRB- denotes (
T14036 11501-11506 CD denotes 1×105
T14037 11507-11512 NN denotes cells
T14038 11513-11515 IN denotes in
T14039 11516-11519 CD denotes 0.1
T14040 11520-11522 NN denotes ml
T14041 11523-11531 JJ denotes complete
T14042 11532-11538 NN denotes medium
T14043 11538-11539 -RRB- denotes )
T14044 11540-11544 VB denotes were
T14045 11545-11551 VB denotes washed
T14046 11552-11555 CC denotes and
T14047 11556-11566 VB denotes stimulated
T14048 11567-11571 IN denotes with
T14049 11572-11578 NN denotes medium
T14050 11578-11579 -COMMA- denotes ,
T14051 11580-11583 CD denotes 100
T14052 11584-11589 NN denotes ng/ml
T14053 11590-11593 NN denotes LPS
T14054 11594-11596 CC denotes or
T14055 11597-11599 CD denotes 25
T14056 11600-11605 NN denotes µg/ml
T14057 11606-11610 NN denotes poly
T14058 11611-11612 NN denotes I
T14059 11612-11613 -COLON- denotes :
T14060 11613-11614 NN denotes C
T14061 11615-11618 IN denotes for
T14062 11619-11621 CD denotes 24
T14063 11622-11627 NN denotes hours
T14064 11629-11641 NN denotes Supernatants
T14065 11642-11646 VB denotes were
T14066 11647-11656 VB denotes collected
T14067 11657-11660 IN denotes for
T14068 11661-11666 NN denotes ELISA
T14069 11667-11669 IN denotes of
T14070 11670-11677 NN denotes IL12P70
T14071 11677-11678 -COMMA- denotes ,
T14072 11679-11682 NN denotes IL6
T14073 11682-11683 -COMMA- denotes ,
T14074 11684-11687 CC denotes and
T14075 11688-11693 NN denotes GMCSF
T14076 11693-11694 -COMMA- denotes ,
T14077 11695-11698 CC denotes and
T14078 11699-11702 IN denotes for
T14079 11703-11717 NN denotes quantification
T14080 11718-11720 IN denotes of
T14081 11721-11727 JJ denotes nitric
T14082 11728-11733 NN denotes oxide
T14083 11734-11735 -LRB- denotes (
T14084 11735-11737 NN denotes NO
T14085 11737-11738 -RRB- denotes )
T14086 11738-11739 -LRB- denotes .
T14087 11740-11743 NN denotes (E–
T14088 11743-11744 -RRB- denotes F
T14089 11744-11752 NN denotes ) Gradie
T14090 11752-11759 NN denotes nt numb
T14091 11759-11760 -LRB- denotes e
T14092 11760-11765 CD denotes rs (1
T14093 11765-11766 -COMMA- denotes ×
T14094 11766-11771 CD denotes 104,
T14095 11771-11772 -COMMA- denotes 2
T14096 11772-11775 CC denotes ×10
T14097 11775-11780 CD denotes 4, an
T14098 11780-11785 NN denotes d 4×1
T14099 11785-11787 IN denotes 04
T14100 11788-11791 CD denotes cel
T14101 11791-11793 NN denotes ls
T14102 11794-11802 JJ denotes in 0.1 m
T14103 11802-11808 NN denotes L comp
T14104 11808-11809 -RRB- denotes l
T14105 11809-11811 IN denotes et
T14106 11811-11815 NN denotes e me
T14107 11815-11819 VB denotes dium
T14108 11819-11823 VB denotes ) of
T14109 11824-11830 NN denotes BMDC w
T14110 11830-11835 NN denotes ere u
T14111 11835-11838 NN denotes sed
T14112 11839-11850 NN denotes for100 ng/m
T14113 11869-11874 IN denotes After
T14114 11875-11877 CD denotes 24
T14115 11878-11883 NN denotes hours
T14116 11883-11884 -COMMA- denotes ,
T14117 11885-11888 DT denotes the
T14118 11889-11896 NN denotes amounts
T14119 11897-11899 IN denotes of
T14120 11900-11907 NN denotes IL12P70
T14121 11908-11911 CC denotes and
T14122 11912-11915 NN denotes IL6
T14123 11916-11920 IN denotes from
T14124 11921-11924 DT denotes the
T14125 11925-11936 NN denotes supernatant
T14126 11937-11941 VB denotes were
T14127 11942-11951 VB denotes measured.
T14128 11952-11953 -LRB- denotes (
T14129 11953-11954 NN denotes G
T14130 11954-11955 -RRB- denotes )
T14131 11956-11959 DT denotes The
T14132 11960-11964 NN denotes cpdm
T14133 11965-11969 NN denotes mice
T14134 11970-11977 VB denotes rescued
T14135 11978-11980 IN denotes by
T14136 11981-11999 JJ denotes Sharpin-containing
T14137 12000-12003 NN denotes BAC
T14138 12004-12007 VB denotes had
T14139 12008-12016 JJ denotes complete
T14140 12017-12026 NN denotes remission
T14141 12027-12029 IN denotes of
T14142 12030-12033 DT denotes the
T14143 12034-12046 JJ denotes inflammatory
T14144 12047-12056 NN denotes phenotype
T14145 12057-12058 -LRB- denotes [
T14146 12058-12059 CD denotes 2
T14147 12059-12060 -RRB- denotes ]
T14148 12062-12066 NN denotes BMDC
T14149 12067-12076 VB denotes developed
T14150 12077-12081 IN denotes from
T14151 12082-12086 NN denotes cpdm
T14152 12087-12090 CC denotes and
T14153 12091-12098 VB denotes rescued
T14154 12099-12103 NN denotes cpdm
T14155 12104-12108 NN denotes mice
T14156 12109-12113 VB denotes were
T14157 12114-12120 VB denotes plated
T14158 12121-12122 -LRB- denotes (
T14159 12122-12127 CD denotes 1×106
T14160 12128-12133 NN denotes cells
T14161 12134-12136 IN denotes in
T14162 12137-12140 CD denotes 0.3
T14163 12141-12143 NN denotes mL
T14164 12143-12144 -RRB- denotes )
T14165 12145-12148 CC denotes and
T14166 12149-12159 VB denotes stimulated
T14167 12160-12164 IN denotes with
T14168 12165-12168 CD denotes 100
T14169 12169-12174 NN denotes ng/mL
T14170 12175-12178 NN denotes LPS
T14171 12180-12185 IN denotes After
T14172 12186-12188 CD denotes 24
T14173 12189-12194 NN denotes hours
T14174 12194-12195 -COMMA- denotes ,
T14175 12196-12208 NN denotes supernatants
T14176 12209-12213 VB denotes were
T14177 12214-12223 VB denotes collected
T14178 12224-12227 IN denotes for
T14179 12228-12236 NN denotes analysis
T14180 12237-12239 IN denotes of
T14181 12240-12247 NN denotes IL12P70
T14182 12248-12258 NN denotes production
T14183 12260-12264 NN denotes Data
T14184 12265-12268 VB denotes are
T14185 12269-12283 JJ denotes representative
T14186 12284-12286 IN denotes of
T14187 12287-12292 CD denotes three
T14188 12293-12304 JJ denotes independent
T14189 12305-12317 NN denotes experiments.
T14190 12318-12319 SYM denotes *
T14191 12320-12321 NN denotes P
T14192 12321-12322 SYM denotes <
T14193 12322-12326 CD denotes 0.01
T14194 12326-12327 -COLON- denotes ;
T14195 12328-12330 SYM denotes **
T14196 12331-12332 NN denotes P
T14197 12332-12333 SYM denotes <
T14198 12333-12338 CD denotes 0.005
T14388 12384-12393 VB denotes Decreased
T14389 12394-12398 NN denotes mRNA
T14390 12399-12405 NN denotes levels
T14391 12406-12408 IN denotes of
T14392 12409-12421 JJ denotes inflammatory
T14393 12422-12431 NN denotes cytokines
T14394 12432-12436 IN denotes from
T14395 12437-12441 NN denotes cpdm
T14396 12442-12446 NN denotes BMDC
T14397 12448-12456 VB denotes Cultured
T14398 12457-12459 NN denotes WT
T14399 12460-12463 CC denotes and
T14400 12464-12468 NN denotes cpdm
T14401 12469-12473 NN denotes BMDC
T14402 12474-12475 -LRB- denotes (
T14403 12475-12480 CD denotes 5×105
T14404 12481-12486 NN denotes cells
T14405 12487-12489 IN denotes in
T14406 12490-12493 CD denotes 0.2
T14407 12494-12496 NN denotes ml
T14408 12497-12505 JJ denotes complete
T14409 12506-12512 NN denotes medium
T14410 12512-12513 -RRB- denotes )
T14411 12514-12518 VB denotes were
T14412 12519-12525 VB denotes washed
T14413 12526-12529 CC denotes and
T14414 12530-12540 VB denotes stimulated
T14415 12541-12545 IN denotes with
T14416 12546-12549 CD denotes 100
T14417 12550-12555 NN denotes ng/ml
T14418 12556-12559 NN denotes LPS
T14419 12560-12561 -LRB- denotes (
T14420 12561-12562 NN denotes A
T14421 12562-12563 -COMMA- denotes ,
T14422 12563-12564 NN denotes C
T14423 12564-12565 -COMMA- denotes ,
T14424 12565-12566 NN denotes E
T14425 12566-12567 -COMMA- denotes ,
T14426 12567-12568 NN denotes G
T14427 12568-12569 -RRB- denotes )
T14428 12570-12572 CC denotes or
T14429 12573-12575 CD denotes 25
T14430 12576-12581 NN denotes µg/ml
T14431 12582-12586 NN denotes poly
T14432 12587-12588 NN denotes I
T14433 12588-12589 SYM denotes :
T14434 12589-12590 NN denotes C
T14435 12591-12592 -LRB- denotes (
T14436 12592-12593 NN denotes B
T14437 12593-12594 -COMMA- denotes ,
T14438 12594-12595 NNP denotes D
T14439 12595-12596 -COMMA- denotes ,
T14440 12596-12597 NNP denotes F
T14441 12597-12598 -COMMA- denotes ,
T14442 12598-12599 NN denotes H
T14443 12599-12600 -RRB- denotes )
T14444 12602-12604 IN denotes At
T14445 12605-12606 CD denotes 0
T14446 12606-12607 -COMMA- denotes ,
T14447 12608-12609 CD denotes 1
T14448 12610-12613 CC denotes and
T14449 12614-12615 CD denotes 2
T14450 12616-12621 NN denotes hours
T14451 12621-12622 -COMMA- denotes ,
T14452 12623-12628 JJ denotes total
T14453 12629-12632 NN denotes RNA
T14454 12633-12636 VB denotes was
T14455 12637-12646 VB denotes extracted
T14456 12647-12650 CC denotes and
T14457 12651-12658 JJ denotes subject
T14458 12659-12661 TO denotes to
T14459 12662-12669 NN denotes qRT-PCR
T14460 12670-12672 TO denotes to
T14461 12673-12680 VB denotes measure
T14462 12681-12684 DT denotes the
T14463 12685-12695 NN denotes expression
T14464 12696-12698 IN denotes of
T14465 12699-12706 NN denotes Il12p40
T14466 12707-12708 -LRB- denotes (
T14467 12708-12709 NN denotes A
T14468 12709-12710 -COMMA- denotes ,
T14469 12710-12711 NN denotes B
T14470 12711-12712 -RRB- denotes )
T14471 12712-12713 -COMMA- denotes ,
T14472 12714-12717 NN denotes Il6
T14473 12718-12719 -LRB- denotes (
T14474 12719-12720 NN denotes C
T14475 12720-12721 -COMMA- denotes ,
T14476 12721-12722 NN denotes D
T14477 12722-12723 -RRB- denotes )
T14478 12723-12724 -COMMA- denotes ,
T14479 12725-12730 NN denotes Gmcsf
T14480 12731-12732 -LRB- denotes (
T14481 12732-12733 NN denotes E
T14482 12733-12734 -COMMA- denotes ,
T14483 12734-12735 NN denotes F
T14484 12735-12736 -RRB- denotes )
T14485 12736-12737 -COMMA- denotes ,
T14486 12738-12741 CC denotes and
T14487 12742-12746 NN denotes Ifnb
T14488 12747-12748 -LRB- denotes (
T14489 12748-12749 NN denotes G
T14490 12749-12750 -COMMA- denotes ,
T14491 12750-12751 NN denotes H
T14492 12751-12752 -RRB- denotes )
T14493 12753-12757 NN denotes mRNA
T14494 12759-12763 NN denotes Bars
T14495 12764-12773 VB denotes represent
T14496 12774-12778 JJ denotes mean
T14497 12779-12780 JJ denotes ±
T14498 12781-12783 NN denotes SD
T14499 12785-12789 NN denotes Data
T14500 12790-12793 VB denotes are
T14501 12794-12808 JJ denotes representative
T14502 12809-12811 IN denotes of
T14503 12812-12815 CD denotes two
T14504 12816-12827 JJ denotes independent
T14505 12828-12839 NN denotes experiments
T4912 12842-12850 JJ denotes Impaired
T4913 12851-12859 NN denotes cytokine
T4914 12860-12870 NN denotes production
T4915 12871-12873 IN denotes by
T4916 12874-12878 NN denotes cpdm
T4917 12879-12883 NN denotes BMDC
T4918 12884-12886 VB denotes is
T4919 12887-12897 VB denotes correlated
T4920 12898-12902 IN denotes with
T4921 12903-12912 JJ denotes selective
T4922 12913-12920 NN denotes defects
T4923 12921-12923 IN denotes in
T4924 12924-12929 NN denotes NF-κB
T4925 12930-12939 NN denotes signaling
T4926 12940-12945 EX denotes There
T4927 12946-12949 VB denotes are
T4928 12950-12951 DT denotes a
T4929 12952-12958 NN denotes number
T4930 12959-12961 IN denotes of
T4931 12962-12970 JJ denotes possible
T4932 12971-12983 NN denotes explanations
T4933 12984-12987 IN denotes for
T4934 12988-12991 DT denotes the
T4935 12992-13001 JJ denotes defective
T4936 13002-13010 NN denotes cytokine
T4937 13011-13020 NN denotes secretion
T4938 13021-13023 IN denotes in
T4939 13024-13034 VB denotes stimulated
T4940 13035-13039 NN denotes cpdm
T4941 13040-13044 NN denotes BMDC
T4942 13044-13045 -COMMA- denotes ,
T4943 13046-13055 VB denotes including
T4944 13056-13057 CD denotes 1
T4945 13057-13058 -RRB- denotes )
T4946 13059-13066 VB denotes reduced
T4947 13067-13074 NN denotes surface
T4948 13075-13085 NN denotes expression
T4949 13086-13088 IN denotes of
T4950 13089-13092 DT denotes the
T4951 13093-13096 NN denotes LPS
T4952 13097-13105 NN denotes receptor
T4953 13106-13113 NN denotes complex
T4954 13113-13114 -COMMA- denotes ,
T4955 13115-13116 CD denotes 2
T4956 13116-13117 -RRB- denotes )
T4957 13118-13127 VB denotes increased
T4958 13128-13138 NN denotes production
T4959 13139-13141 IN denotes of
T4960 13142-13159 JJ denotes anti-inflammatory
T4961 13160-13169 NN denotes mediators
T4962 13169-13170 -COMMA- denotes ,
T4963 13171-13172 CD denotes 3
T4964 13172-13173 -RRB- denotes )
T4965 13174-13183 VB denotes increased
T4966 13184-13194 NN denotes expression
T4967 13195-13197 IN denotes of
T4968 13198-13206 JJ denotes negative
T4969 13207-13217 NN denotes regulators
T4970 13218-13220 IN denotes of
T4971 13221-13224 NN denotes TLR
T4972 13225-13233 NN denotes pathways
T4973 13233-13234 -COMMA- denotes ,
T4974 13235-13238 CC denotes and
T4975 13239-13240 CD denotes 4
T4976 13240-13241 -RRB- denotes )
T4977 13242-13250 JJ denotes impaired
T4978 13251-13262 JJ denotes TLR-induced
T4979 13263-13272 NN denotes signaling
T4980 13273-13283 NN denotes activation
T4981 13285-13287 PRP denotes We
T4982 13288-13298 VB denotes determined
T4983 13299-13302 DT denotes the
T4984 13303-13310 NN denotes surface
T4985 13311-13321 NN denotes expression
T4986 13322-13324 IN denotes of
T4987 13325-13328 DT denotes the
T4988 13329-13332 NN denotes LPS
T4989 13333-13341 NN denotes receptor
T4990 13342-13349 NN denotes complex
T4991 13350-13354 WDT denotes that
T4992 13355-13364 VB denotes comprises
T4993 13365-13369 NN denotes TLR4
T4994 13369-13370 -COMMA- denotes ,
T4995 13371-13374 DT denotes the
T4996 13375-13384 JJ denotes accessory
T4997 13385-13393 NN denotes proteins
T4998 13394-13398 NN denotes CD14
T4999 13399-13402 CC denotes and
T5000 13403-13410 JJ denotes myeloid
T5001 13411-13426 NN denotes differentiation
T5002 13427-13433 NN denotes factor
T5003 13434-13435 CD denotes 2
T5004 13436-13437 -LRB- denotes (
T5005 13437-13445 NN denotes MD2/LY96
T5006 13445-13446 -RRB- denotes )
T5007 13447-13448 -LRB- denotes [
T5008 13448-13450 CD denotes 19
T5009 13450-13451 -RRB- denotes ]
T5010 13453-13457 NN denotes Flow
T5011 13458-13468 JJ denotes cytometric
T5012 13469-13477 NN denotes analysis
T5013 13478-13483 VB denotes shows
T5014 13484-13488 IN denotes that
T5015 13489-13492 DT denotes the
T5016 13493-13503 NN denotes expression
T5017 13504-13510 NN denotes levels
T5018 13511-13513 IN denotes of
T5019 13514-13518 NN denotes CD14
T5020 13519-13522 CC denotes and
T5021 13523-13531 NN denotes TLR4/MD2
T5022 13532-13539 IN denotes between
T5023 13540-13542 NN denotes WT
T5024 13543-13546 CC denotes and
T5025 13547-13551 NN denotes cpdm
T5026 13552-13556 NN denotes BMDC
T5027 13557-13561 VB denotes were
T5028 13562-13569 JJ denotes similar
T5029 13570-13571 -LRB- denotes (
T5030 13571-13575 NN denotes Fig.
T5031 13576-13578 NN denotes 5A
T5032 13578-13579 -RRB- denotes )
T5033 13581-13583 PRP denotes We
T5034 13584-13588 RB denotes then
T5035 13589-13599 VB denotes quantified
T5036 13600-13603 DT denotes the
T5037 13604-13613 NN denotes secretion
T5038 13614-13616 IN denotes of
T5039 13617-13620 DT denotes the
T5040 13621-13632 JJ denotes suppressive
T5041 13633-13642 NN denotes cytokines
T5042 13643-13647 NN denotes IL10
T5043 13648-13652 WDT denotes that
T5044 13653-13656 MD denotes can
T5045 13657-13664 VB denotes inhibit
T5046 13665-13669 NN denotes IL12
T5047 13670-13679 NN denotes secretion
T5048 13680-13682 IN denotes in
T5049 13683-13685 DT denotes an
T5050 13686-13695 JJ denotes autocrine
T5051 13696-13702 NN denotes manner
T5052 13703-13704 -LRB- denotes [
T5053 13704-13706 CD denotes 20
T5054 13706-13707 -RRB- denotes ]
T5055 13707-13708 -COMMA- denotes ,
T5056 13709-13710 -LRB- denotes [
T5057 13710-13712 CD denotes 21
T5058 13712-13713 -RRB- denotes ]
T5059 13715-13718 DT denotes The
T5060 13719-13731 NN denotes supernatants
T5061 13732-13736 IN denotes from
T5062 13737-13751 JJ denotes LPS-stimulated
T5063 13752-13756 NN denotes cpdm
T5064 13757-13761 NN denotes BMDC
T5065 13762-13771 VB denotes contained
T5066 13772-13785 RB denotes significantly
T5067 13786-13791 JJ denotes lower
T5068 13792-13798 NN denotes levels
T5069 13799-13801 IN denotes of
T5070 13802-13806 NN denotes IL10
T5071 13807-13811 IN denotes than
T5072 13812-13822 VB denotes stimulated
T5073 13823-13825 NN denotes WT
T5074 13826-13830 NN denotes BMDC
T5075 13831-13832 -LRB- denotes (
T5076 13832-13836 NN denotes Fig.
T5077 13837-13839 NN denotes 5B
T5078 13839-13840 -RRB- denotes )
T5079 13840-13841 -COMMA- denotes ,
T5080 13842-13852 VB denotes suggesting
T5081 13853-13857 IN denotes that
T5082 13858-13862 NN denotes IL10
T5083 13863-13866 VB denotes was
T5084 13867-13870 RB denotes not
T5085 13871-13882 JJ denotes responsible
T5086 13883-13886 IN denotes for
T5087 13887-13896 VB denotes decreased
T5088 13897-13906 NN denotes secretion
T5089 13907-13909 IN denotes of
T5090 13910-13917 NN denotes IL12P70
T5091 13918-13920 IN denotes by
T5092 13921-13925 NN denotes cpdm
T5093 13926-13930 NN denotes BMDC
T5094 13932-13941 VB denotes Increased
T5095 13942-13952 NN denotes expression
T5096 13953-13955 IN denotes of
T5097 13956-13957 DT denotes a
T5098 13958-13966 JJ denotes negative
T5099 13967-13976 NN denotes regulator
T5100 13977-13979 IN denotes of
T5101 13980-13983 NN denotes TLR
T5102 13984-13993 NN denotes signaling
T5103 13994-13998 JJ denotes such
T5104 13999-14001 IN denotes as
T5105 14002-14005 NN denotes A20
T5106 14006-14007 -LRB- denotes [
T5107 14007-14009 CD denotes 22
T5108 14009-14010 -RRB- denotes ]
T5109 14011-14014 MD denotes may
T5110 14015-14019 RB denotes also
T5111 14020-14028 VB denotes suppress
T5112 14029-14037 NN denotes cytokine
T5113 14038-14047 NN denotes secretion
T5114 14049-14056 RB denotes However
T5115 14056-14057 -COMMA- denotes ,
T5116 14058-14061 DT denotes the
T5117 14062-14072 NN denotes transcript
T5118 14073-14078 NN denotes level
T5119 14079-14081 IN denotes of
T5120 14082-14085 NN denotes A20
T5121 14086-14089 VB denotes was
T5122 14090-14095 JJ denotes lower
T5123 14096-14098 IN denotes in
T5124 14099-14112 JJ denotes LPS-activated
T5125 14113-14117 NN denotes cpdm
T5126 14118-14122 NN denotes BMDC
T5127 14123-14127 IN denotes than
T5128 14128-14130 JJ denotes WT
T5129 14131-14139 NN denotes controls
T5130 14140-14141 -LRB- denotes (
T5131 14141-14145 NNP denotes Fig.
T5132 14146-14148 NN denotes 5C
T5133 14148-14149 -RRB- denotes )
T5134 14149-14150 -COMMA- denotes ,
T5135 14151-14158 RB denotes thereby
T5136 14159-14165 VB denotes ruling
T5137 14166-14169 RP denotes out
T5138 14170-14184 NN denotes overexpression
T5139 14185-14187 IN denotes of
T5140 14188-14191 NN denotes A20
T5141 14192-14194 IN denotes as
T5142 14195-14196 DT denotes a
T5143 14197-14203 NN denotes factor
T5144 14204-14206 IN denotes in
T5145 14207-14210 DT denotes the
T5146 14211-14218 VB denotes reduced
T5147 14219-14227 NN denotes cytokine
T5148 14228-14238 NN denotes production
T14698 14284-14290 JJ denotes Normal
T14699 14291-14295 NN denotes TLR4
T14700 14296-14299 CC denotes and
T14701 14300-14303 NN denotes MD2
T14702 14304-14314 NN denotes expression
T14703 14315-14318 CC denotes and
T14704 14319-14328 VB denotes decreased
T14705 14329-14333 NN denotes IL10
T14706 14334-14343 NN denotes secretion
T14707 14344-14347 CC denotes and
T14708 14348-14351 NN denotes A20
T14709 14352-14362 NN denotes expression
T14710 14363-14365 IN denotes by
T14711 14366-14370 NN denotes cpdm
T14712 14371-14375 NN denotes BMDC
T14713 14377-14378 -LRB- denotes (
T14714 14378-14379 NN denotes A
T14715 14379-14380 -RRB- denotes )
T14716 14381-14393 JJ denotes Unstimulated
T14717 14394-14396 NN denotes WT
T14718 14397-14400 CC denotes and
T14719 14401-14405 NN denotes cpdm
T14720 14406-14410 NN denotes BMDC
T14721 14411-14412 -LRB- denotes (
T14722 14412-14417 CD denotes 5×105
T14723 14417-14418 -RRB- denotes )
T14724 14419-14423 VB denotes were
T14725 14424-14431 VB denotes labeled
T14726 14432-14436 IN denotes with
T14727 14437-14447 JJ denotes PE-labeled
T14728 14448-14461 NN denotes anti-TLR4/MD2
T14729 14462-14464 CC denotes or
T14730 14465-14474 NN denotes anti-CD14
T14731 14475-14478 CC denotes and
T14732 14479-14483 RB denotes then
T14733 14484-14491 JJ denotes subject
T14734 14492-14494 TO denotes to
T14735 14495-14499 VB denotes flow
T14736 14500-14509 NN denotes cytometry
T14737 14510-14518 NN denotes analysis
T14738 14520-14529 JJ denotes Unstained
T14739 14530-14535 NN denotes cells
T14740 14536-14541 VB denotes serve
T14741 14542-14544 IN denotes as
T14742 14545-14553 JJ denotes negative
T14743 14554-14563 NN denotes controls.
T14744 14564-14565 -LRB- denotes (
T14745 14565-14566 NN denotes B
T14746 14566-14567 -RRB- denotes )
T14747 14568-14576 JJ denotes Cultured
T14748 14577-14579 NN denotes WT
T14749 14580-14583 CC denotes and
T14750 14584-14588 NN denotes cpdm
T14751 14589-14593 NN denotes BMDC
T14752 14594-14595 -LRB- denotes (
T14753 14595-14600 CD denotes 1×105
T14754 14601-14606 NN denotes cells
T14755 14607-14609 IN denotes in
T14756 14610-14613 CD denotes 0.1
T14757 14614-14616 NN denotes ml
T14758 14617-14625 JJ denotes complete
T14759 14626-14632 NN denotes medium
T14760 14632-14633 -RRB- denotes )
T14761 14634-14638 VB denotes were
T14762 14639-14645 VB denotes washed
T14763 14646-14649 CC denotes and
T14764 14650-14660 VB denotes stimulated
T14765 14661-14665 IN denotes with
T14766 14666-14672 NN denotes medium
T14767 14672-14673 -COMMA- denotes ,
T14768 14674-14677 CD denotes 100
T14769 14678-14683 NN denotes ng/ml
T14770 14684-14687 NN denotes LPS
T14771 14688-14690 CC denotes or
T14772 14691-14693 CD denotes 25
T14773 14694-14699 NN denotes µg/ml
T14774 14700-14704 NN denotes poly
T14775 14705-14706 NN denotes I
T14776 14706-14707 -COLON- denotes :
T14777 14707-14708 NN denotes C
T14778 14709-14712 IN denotes for
T14779 14713-14715 CD denotes 24
T14780 14716-14721 NN denotes hours
T14781 14723-14735 NN denotes Supernatants
T14782 14736-14740 VB denotes were
T14783 14741-14750 VB denotes collected
T14784 14751-14754 IN denotes for
T14785 14755-14760 NN denotes ELISA
T14786 14761-14763 IN denotes of
T14787 14764-14769 NN denotes IL10.
T14788 14770-14771 -LRB- denotes (
T14789 14771-14772 NN denotes C
T14790 14772-14773 -RRB- denotes )
T14791 14774-14782 JJ denotes Cultured
T14792 14783-14785 NN denotes WT
T14793 14786-14789 CC denotes and
T14794 14790-14794 NN denotes cpdm
T14795 14795-14799 NN denotes BMDC
T14796 14800-14801 -LRB- denotes (
T14797 14801-14806 CD denotes 5×105
T14798 14807-14812 NN denotes cells
T14799 14813-14815 IN denotes in
T14800 14816-14819 CD denotes 0.2
T14801 14820-14822 NN denotes ml
T14802 14823-14831 JJ denotes complete
T14803 14832-14838 NN denotes medium
T14804 14838-14839 -RRB- denotes )
T14805 14840-14844 VB denotes were
T14806 14845-14851 VB denotes washed
T14807 14852-14855 CC denotes and
T14808 14856-14866 VB denotes stimulated
T14809 14867-14871 IN denotes with
T14810 14872-14875 CD denotes 100
T14811 14876-14881 NN denotes ng/ml
T14812 14882-14885 NN denotes LPS
T14813 14886-14888 CC denotes or
T14814 14889-14891 CD denotes 25
T14815 14892-14897 NN denotes µg/ml
T14816 14898-14902 NN denotes poly
T14817 14903-14904 CD denotes I
T14818 14904-14905 -COLON- denotes :
T14819 14905-14907 NNP denotes C.
T14820 14908-14910 IN denotes At
T14821 14911-14912 CD denotes 0
T14822 14912-14913 -COMMA- denotes ,
T14823 14914-14915 CD denotes 1
T14824 14915-14916 -COMMA- denotes ,
T14825 14917-14920 CC denotes and
T14826 14921-14922 CD denotes 2
T14827 14923-14928 NN denotes hours
T14828 14928-14929 -COMMA- denotes ,
T14829 14930-14935 JJ denotes total
T14830 14936-14939 NN denotes RNA
T14831 14940-14943 VB denotes was
T14832 14944-14953 VB denotes extracted
T14833 14954-14957 CC denotes and
T14834 14958-14965 JJ denotes subject
T14835 14966-14968 TO denotes to
T14836 14969-14976 NN denotes qRT-PCR
T14837 14977-14979 TO denotes to
T14838 14980-14987 VB denotes measure
T14839 14988-14991 DT denotes the
T14840 14992-15002 NN denotes production
T14841 15003-15005 IN denotes of
T14842 15006-15009 NN denotes A20
T5149 15014-15017 DT denotes The
T5150 15018-15031 NN denotes transcription
T5151 15032-15034 IN denotes of
T5152 15035-15049 JJ denotes TLR3/4-induced
T5153 15050-15065 JJ denotes proinflammatory
T5154 15066-15079 NN denotes intermediates
T5155 15080-15082 VB denotes is
T5156 15083-15090 RB denotes tightly
T5157 15091-15100 VB denotes regulated
T5158 15101-15103 IN denotes by
T5159 15104-15112 JJ denotes cellular
T5160 15113-15122 NN denotes signaling
T5161 15123-15131 NN denotes pathways
T5162 15131-15132 -COMMA- denotes ,
T5163 15133-15135 IN denotes in
T5164 15136-15146 JJ denotes particular
T5165 15147-15152 NN denotes NF-κB
T5166 15152-15153 -COMMA- denotes ,
T5167 15154-15163 NN denotes TBK1/IRF3
T5168 15163-15164 -COMMA- denotes ,
T5169 15165-15168 CC denotes and
T5170 15169-15173 NN denotes MAPK
T5171 15174-15175 -LRB- denotes [
T5172 15175-15177 CD denotes 23
T5173 15177-15178 -RRB- denotes ]
T5174 15178-15179 NNP denotes –
T5175 15179-15180 -LRB- denotes [
T5176 15180-15182 CD denotes 27
T5177 15182-15183 -RRB- denotes ]
T5178 15185-15187 PRP denotes We
T5179 15188-15192 RB denotes next
T5180 15193-15203 VB denotes determined
T5181 15204-15206 IN denotes if
T5182 15207-15216 VB denotes disrupted
T5183 15217-15222 NN denotes NF-κB
T5184 15222-15223 -COMMA- denotes ,
T5185 15224-15233 NN denotes TBK1/IRF3
T5186 15233-15234 -COMMA- denotes ,
T5187 15235-15241 CC denotes and/or
T5188 15242-15246 NN denotes MAPK
T5189 15247-15256 NN denotes signaling
T5190 15257-15260 MD denotes may
T5191 15261-15269 VB denotes underlie
T5192 15270-15273 DT denotes the
T5193 15274-15282 JJ denotes impaired
T5194 15283-15291 NN denotes cytokine
T5195 15292-15302 NN denotes production
T5196 15303-15307 IN denotes from
T5197 15308-15318 VB denotes stimulated
T5198 15319-15336 JJ denotes Sharpin-deficient
T5199 15337-15341 NN denotes BMDC
T5200 15343-15359 JJ denotes Stimulus-induced
T5201 15360-15375 NN denotes phosphorylation
T5202 15376-15378 IN denotes of
T5203 15379-15382 DT denotes the
T5204 15383-15386 NN denotes IκB
T5205 15387-15393 NN denotes kinase
T5206 15394-15395 -LRB- denotes (
T5207 15395-15401 NN denotes IKK1/2
T5208 15401-15402 -RRB- denotes )
T5209 15403-15405 VB denotes is
T5210 15406-15408 DT denotes an
T5211 15409-15418 JJ denotes essential
T5212 15419-15423 NN denotes step
T5213 15424-15426 IN denotes in
T5214 15427-15432 NN denotes NF-κB
T5215 15433-15442 NN denotes signaling
T5216 15442-15443 -COMMA- denotes ,
T5217 15444-15452 VB denotes allowing
T5218 15453-15468 NN denotes phosphorylation
T5219 15469-15472 CC denotes and
T5220 15473-15492 JJ denotes proteasome-mediated
T5221 15493-15504 NN denotes degradation
T5222 15505-15507 IN denotes of
T5223 15508-15511 DT denotes the
T5224 15512-15517 NN denotes NF-κB
T5225 15518-15527 NN denotes inhibitor
T5226 15528-15532 NN denotes IκBα
T5227 15533-15535 TO denotes to
T5228 15536-15543 VB denotes release
T5229 15544-15547 DT denotes the
T5230 15548-15553 NN denotes NF-κB
T5231 15554-15567 NN denotes transcription
T5232 15568-15575 NN denotes factors
T5233 15576-15580 IN denotes into
T5234 15581-15584 DT denotes the
T5235 15585-15592 NN denotes nucleus
T5236 15594-15597 DT denotes The
T5237 15598-15604 NN denotes amount
T5238 15605-15607 IN denotes of
T5239 15608-15622 VB denotes phosphorylated
T5240 15623-15629 NN denotes IKK1/2
T5241 15630-15631 -LRB- denotes (
T5242 15631-15639 NN denotes p-IKK1/2
T5243 15639-15640 -RRB- denotes )
T5244 15641-15644 CC denotes and
T5245 15645-15649 NN denotes IκBα
T5246 15650-15651 -LRB- denotes (
T5247 15651-15657 NN denotes p-IκBα
T5248 15657-15658 -RRB- denotes )
T5249 15659-15668 VB denotes following
T5250 15669-15679 NN denotes incubation
T5251 15680-15684 IN denotes with
T5252 15685-15688 NN denotes LPS
T5253 15689-15691 CC denotes or
T5254 15692-15696 NN denotes poly
T5255 15697-15698 NN denotes I
T5256 15698-15699 SYM denotes :
T5257 15699-15700 NN denotes C
T5258 15701-15704 VB denotes was
T5259 15705-15713 RB denotes severely
T5260 15714-15723 VB denotes decreased
T5261 15724-15726 IN denotes in
T5262 15727-15731 NN denotes cpdm
T5263 15732-15736 NN denotes BMDC
T5264 15737-15739 IN denotes as
T5265 15740-15748 VB denotes compared
T5266 15749-15753 IN denotes with
T5267 15754-15756 JJ denotes WT
T5268 15757-15765 NN denotes controls
T5269 15766-15767 -LRB- denotes (
T5270 15767-15771 NN denotes Fig.
T5271 15772-15773 CD denotes 6
T5272 15773-15774 -RRB- denotes )
T5273 15776-15779 DT denotes The
T5274 15780-15784 NN denotes cpdm
T5275 15785-15789 NN denotes BMDC
T5276 15790-15799 VB denotes exhibited
T5277 15800-15807 JJ denotes similar
T5278 15808-15814 NN denotes levels
T5279 15815-15817 IN denotes of
T5280 15818-15822 NN denotes TBK1
T5281 15822-15823 -COMMA- denotes ,
T5282 15824-15830 NN denotes ERK1/2
T5283 15830-15831 -COMMA- denotes ,
T5284 15832-15835 CC denotes and
T5285 15836-15839 NN denotes p38
T5286 15840-15855 NN denotes phosphorylation
T5287 15856-15858 TO denotes to
T5288 15859-15864 DT denotes those
T5289 15865-15867 IN denotes of
T5290 15868-15870 JJ denotes WT
T5291 15871-15876 NN denotes cells
T5292 15877-15878 -LRB- denotes (
T5293 15878-15882 NN denotes Fig.
T5294 15883-15884 CD denotes 6
T5295 15884-15885 -RRB- denotes )
T5296 15887-15892 DT denotes These
T5297 15893-15900 NN denotes results
T5298 15901-15909 VB denotes indicate
T5299 15910-15914 IN denotes that
T5300 15915-15918 DT denotes the
T5301 15919-15926 NN denotes absence
T5302 15927-15929 IN denotes of
T5303 15930-15940 JJ denotes functional
T5304 15941-15948 NN denotes SHARPIN
T5305 15949-15958 VB denotes decreased
T5306 15959-15964 NN denotes NF-κB
T5307 15965-15975 NN denotes activation
T5308 15976-15979 CC denotes but
T5309 15980-15983 VB denotes did
T5310 15984-15987 RB denotes not
T5311 15988-15994 VB denotes affect
T5312 15995-16004 NN denotes TBK1/IRF3
T5313 16004-16005 -COMMA- denotes ,
T5314 16006-16012 NN denotes ERK1/2
T5315 16012-16013 -COMMA- denotes ,
T5316 16014-16017 CC denotes and
T5317 16018-16021 NN denotes p38
T5318 16022-16031 NN denotes signaling
T5319 16032-16034 IN denotes in
T5320 16035-16039 NN denotes BMDC
T14998 16085-16095 NN denotes Inhibition
T14999 16096-16098 IN denotes of
T15000 16099-16104 NN denotes NF-κB
T15001 16105-16114 NN denotes signaling
T15002 16115-16117 IN denotes in
T15003 16118-16122 NN denotes cpdm
T15004 16123-16127 NN denotes BMDC
T15005 16129-16131 NN denotes WT
T15006 16132-16135 CC denotes and
T15007 16136-16140 NN denotes cpdm
T15008 16141-16145 NN denotes BMDC
T15009 16146-16147 -LRB- denotes (
T15010 16147-16152 CD denotes 2×106
T15011 16153-16158 NN denotes cells
T15012 16159-16161 IN denotes in
T15013 16162-16165 CD denotes 0.5
T15014 16166-16168 NN denotes mL
T15015 16169-16177 JJ denotes complete
T15016 16178-16184 NN denotes medium
T15017 16184-16185 -RRB- denotes )
T15018 16186-16190 VB denotes were
T15019 16191-16201 VB denotes stimulated
T15020 16202-16206 IN denotes with
T15021 16207-16210 CD denotes 100
T15022 16211-16216 NN denotes ng/mL
T15023 16217-16220 NN denotes LPS
T15024 16221-16222 -LRB- denotes (
T15025 16222-16223 NN denotes A
T15026 16223-16224 -RRB- denotes )
T15027 16225-16227 CC denotes or
T15028 16228-16230 CD denotes 25
T15029 16231-16236 NN denotes µg/mL
T15030 16237-16241 NN denotes poly
T15031 16242-16243 NN denotes I
T15032 16243-16244 SYM denotes :
T15033 16244-16245 NN denotes C
T15034 16246-16247 -LRB- denotes (
T15035 16247-16248 NN denotes B
T15036 16248-16249 -RRB- denotes )
T15037 16251-16253 IN denotes At
T15038 16254-16255 CD denotes 0
T15039 16255-16256 -COMMA- denotes ,
T15040 16257-16259 CD denotes 15
T15041 16259-16260 -COMMA- denotes ,
T15042 16261-16263 CD denotes 30
T15043 16263-16264 -COMMA- denotes ,
T15044 16265-16268 CC denotes and
T15045 16269-16271 CD denotes 60
T15046 16272-16279 NN denotes minutes
T15047 16279-16280 -COMMA- denotes ,
T15048 16281-16291 JJ denotes whole-cell
T15049 16292-16299 NN denotes lysates
T15050 16300-16304 VB denotes were
T15051 16305-16313 VB denotes obtained
T15052 16314-16317 CC denotes and
T15053 16318-16325 JJ denotes subject
T15054 16326-16328 TO denotes to
T15055 16329-16340 NN denotes immunoblots
T15056 16341-16345 IN denotes with
T15057 16346-16356 NN denotes antibodies
T15058 16357-16364 IN denotes against
T15059 16365-16373 NN denotes proteins
T15060 16374-16382 VB denotes involved
T15061 16383-16385 IN denotes in
T15062 16386-16391 NN denotes NF-κB
T15063 16391-16392 -COMMA- denotes ,
T15064 16393-16402 NN denotes TBK1/IRF3
T15065 16402-16403 -COMMA- denotes ,
T15066 16404-16410 NN denotes ERK1/2
T15067 16410-16411 -COMMA- denotes ,
T15068 16412-16415 CC denotes and
T15069 16416-16419 NN denotes p38
T15070 16420-16429 NN denotes signaling
T15071 16430-16438 NN denotes pathways
T15072 16440-16450 NN denotes Beta-actin
T15073 16451-16454 VB denotes was
T15074 16455-16459 VB denotes used
T15075 16460-16462 IN denotes as
T15076 16463-16470 VB denotes loading
T15077 16471-16479 NN denotes control.
T15078 16480-16481 -LRB- denotes (
T15079 16481-16482 NN denotes C
T15080 16482-16483 -RRB- denotes )
T15081 16484-16492 JJ denotes Cellular
T15082 16493-16499 NN denotes levels
T15083 16500-16502 IN denotes of
T15084 16503-16511 NN denotes p-IKK1/2
T15085 16512-16515 CC denotes and
T15086 16516-16522 NN denotes p-IκBα
T15087 16523-16525 IN denotes in
T15088 16526-16530 NN denotes LPS-
T15089 16531-16533 CC denotes or
T15090 16534-16538 NN denotes poly
T15091 16539-16540 CD denotes I
T15092 16540-16541 -COLON- denotes :
T15093 16541-16553 JJ denotes C-stimulated
T15094 16554-16558 NN denotes BMDC
T15095 16559-16563 VB denotes were
T15096 16564-16575 VB denotes quantitated
T15097 16576-16580 IN denotes with
T15098 16581-16587 NN denotes ImageJ
T15099 16588-16589 -LRB- denotes (
T15100 16589-16592 NN denotes NIH
T15101 16592-16593 -RRB- denotes )
T15102 16594-16597 CC denotes and
T15103 16598-16607 VB denotes presented
T15104 16608-16610 IN denotes as
T15105 16611-16616 NN denotes trend
T15106 16617-16622 NN denotes lines
T15107 16624-16631 NN denotes Results
T15108 16632-16635 VB denotes are
T15109 16636-16650 JJ denotes representative
T15110 16651-16653 IN denotes of
T15111 16654-16656 IN denotes at
T15112 16657-16662 JJ denotes least
T15113 16663-16666 CD denotes two
T15114 16667-16678 JJ denotes independent
T15115 16679-16690 NN denotes experiments
T6137 16693-16703 JJ denotes Th2-biased
T6138 16704-16718 NN denotes immunogenicity
T6139 16719-16721 IN denotes of
T6140 16722-16732 VB denotes stimulated
T6141 16733-16737 NN denotes cpdm
T6142 16738-16742 NN denotes BMDC
T6143 16743-16746 DT denotes The
T6144 16747-16756 JJ denotes defective
T6145 16757-16761 NN denotes IL12
T6146 16762-16772 NN denotes production
T6147 16773-16774 -LRB- denotes (
T6148 16774-16778 NN denotes Fig.
T6149 16779-16781 NN denotes 3A
T6150 16781-16782 -RRB- denotes )
T6151 16783-16786 CC denotes and
T6152 16787-16799 JJ denotes Th2-dominant
T6153 16800-16808 NN denotes cytokine
T6154 16809-16816 NN denotes profile
T6155 16817-16819 IN denotes in
T6156 16820-16824 NN denotes cpdm
T6157 16825-16829 NN denotes mice
T6158 16830-16831 -LRB- denotes [
T6159 16831-16832 CD denotes 5
T6160 16832-16833 -RRB- denotes ]
T6161 16834-16841 VB denotes suggest
T6162 16842-16846 IN denotes that
T6163 16847-16850 DT denotes the
T6164 16851-16858 NN denotes absence
T6165 16859-16861 IN denotes of
T6166 16862-16869 NN denotes SHARPIN
T6167 16870-16877 VB denotes affects
T6168 16878-16881 DT denotes the
T6169 16882-16889 NN denotes ability
T6170 16890-16892 IN denotes of
T6171 16893-16897 NN denotes cpdm
T6172 16898-16902 NN denotes BMDC
T6173 16903-16905 TO denotes to
T6174 16906-16912 VB denotes induce
T6175 16913-16914 NN denotes T
T6176 16915-16919 NN denotes cell
T6177 16920-16935 NN denotes differentiation
T6178 16936-16940 IN denotes into
T6179 16941-16949 NN denotes effector
T6180 16950-16955 NN denotes cells
T6181 16957-16967 NN denotes Co-culture
T6182 16968-16970 IN denotes of
T6183 16971-16981 JJ denotes allogeneic
T6184 16982-16987 NN denotes naïve
T6185 16988-16992 JJ denotes CD4+
T6186 16993-16994 NN denotes T
T6187 16995-17000 NN denotes cells
T6188 17001-17005 IN denotes with
T6189 17006-17008 NN denotes WT
T6190 17009-17013 NN denotes BMDC
T6191 17014-17024 VB denotes stimulated
T6192 17025-17029 IN denotes with
T6193 17030-17033 NN denotes LPS
T6194 17034-17036 CC denotes or
T6195 17037-17041 NN denotes poly
T6196 17042-17043 NN denotes I
T6197 17043-17044 SYM denotes :
T6198 17044-17045 NN denotes C
T6199 17046-17054 VB denotes elicited
T6200 17055-17061 JJ denotes robust
T6201 17062-17066 NN denotes IFNγ
T6202 17067-17077 NN denotes production
T6203 17077-17078 -COMMA- denotes ,
T6204 17079-17086 IN denotes whereas
T6205 17087-17090 DT denotes the
T6206 17091-17104 NN denotes concentration
T6207 17105-17107 IN denotes of
T6208 17108-17112 NN denotes IFNγ
T6209 17113-17115 IN denotes in
T6210 17116-17120 NN denotes cpdm
T6211 17121-17127 NN denotes BMDC-T
T6212 17128-17132 NN denotes cell
T6213 17133-17141 NN denotes cultures
T6214 17142-17145 VB denotes was
T6215 17146-17159 RB denotes significantly
T6216 17160-17165 JJ denotes lower
T6217 17166-17171 IN denotes after
T6218 17172-17175 NN denotes LPS
T6219 17176-17187 NN denotes stimulation
T6220 17188-17189 -LRB- denotes (
T6221 17189-17193 NNP denotes Fig.
T6222 17194-17196 NN denotes 7A
T6223 17196-17197 -RRB- denotes )
T6224 17197-17198 -COMMA- denotes ,
T6225 17199-17209 VB denotes indicating
T6226 17210-17218 JJ denotes impaired
T6227 17219-17233 JJ denotes Th1-polarizing
T6228 17234-17243 NN denotes abilities
T6229 17244-17246 IN denotes of
T6230 17247-17251 NN denotes cpdm
T6231 17252-17256 NN denotes BMDC
T6232 17258-17260 IN denotes In
T6233 17261-17269 NN denotes addition
T6234 17270-17272 TO denotes to
T6235 17273-17279 NN denotes TLR3/4
T6236 17280-17288 NN denotes agonists
T6237 17288-17289 -COMMA- denotes ,
T6238 17290-17293 DT denotes the
T6239 17294-17298 NN denotes TLR2
T6240 17299-17305 NN denotes ligand
T6241 17306-17313 NN denotes Pam3CYS
T6242 17314-17317 VB denotes was
T6243 17318-17322 VB denotes used
T6244 17323-17328 IN denotes since
T6245 17329-17331 PRP denotes it
T6246 17332-17335 VB denotes has
T6247 17336-17340 VB denotes been
T6248 17341-17346 VB denotes shown
T6249 17347-17349 TO denotes to
T6250 17350-17356 VB denotes induce
T6251 17357-17361 CC denotes both
T6252 17362-17365 NN denotes Th1
T6253 17366-17369 CC denotes and
T6254 17370-17373 NN denotes Th2
T6255 17374-17383 NN denotes responses
T6256 17384-17385 -LRB- denotes [
T6257 17385-17387 CD denotes 28
T6258 17387-17388 -RRB- denotes ]
T6259 17388-17389 CD denotes –
T6260 17389-17390 -LRB- denotes [
T6261 17390-17392 CD denotes 30
T6262 17392-17393 -RRB- denotes ]
T6263 17395-17410 JJ denotes Pam3CYS-matured
T6264 17411-17413 NN denotes WT
T6265 17414-17418 NN denotes BMDC
T6266 17419-17426 VB denotes induced
T6267 17427-17433 JJ denotes robust
T6268 17434-17438 NN denotes IFNγ
T6269 17439-17449 NN denotes production
T6270 17450-17452 IN denotes at
T6271 17453-17454 DT denotes a
T6272 17455-17468 RB denotes significantly
T6273 17469-17475 JJ denotes higher
T6274 17476-17481 NN denotes level
T6275 17482-17486 IN denotes than
T6276 17487-17491 NN denotes cpdm
T6277 17492-17496 NN denotes BMDC
T6278 17497-17498 -LRB- denotes (
T6279 17498-17502 NNP denotes Fig.
T6280 17503-17505 NN denotes 7A
T6281 17505-17506 -RRB- denotes )
T6282 17508-17511 DT denotes The
T6283 17512-17519 VB denotes reduced
T6284 17520-17523 NN denotes Th1
T6285 17524-17539 NN denotes differentiation
T6286 17540-17549 VB denotes following
T6287 17550-17557 NN denotes Pam3CYS
T6288 17558-17569 NN denotes stimulation
T6289 17570-17572 VB denotes is
T6290 17573-17583 JJ denotes consistent
T6291 17584-17588 IN denotes with
T6292 17589-17592 DT denotes the
T6293 17593-17599 JJ denotes recent
T6294 17600-17606 NN denotes report
T6295 17607-17609 IN denotes of
T6296 17610-17619 VB denotes decreased
T6297 17620-17624 NN denotes IL12
T6298 17625-17635 NN denotes production
T6299 17636-17638 IN denotes in
T6300 17639-17643 NN denotes cpdm
T6301 17644-17655 NN denotes macrophages
T6302 17656-17665 VB denotes following
T6303 17666-17670 NN denotes TLR2
T6304 17671-17682 NN denotes stimulation
T6305 17683-17684 -LRB- denotes [
T6306 17684-17686 CD denotes 31
T6307 17686-17687 -RRB- denotes ]
T6308 17689-17691 IN denotes In
T6309 17692-17700 NN denotes contrast
T6310 17700-17701 -COMMA- denotes ,
T6311 17702-17706 RB denotes more
T6312 17707-17719 JJ denotes Th2-specific
T6313 17720-17723 NN denotes IL4
T6314 17724-17732 NN denotes cytokine
T6315 17733-17736 VB denotes was
T6316 17737-17745 VB denotes produced
T6317 17746-17748 IN denotes in
T6318 17749-17752 DT denotes the
T6319 17753-17757 NN denotes cpdm
T6320 17758-17762 NN denotes BMDC
T6321 17763-17774 NN denotes co-cultures
T6322 17775-17779 IN denotes than
T6323 17780-17783 DT denotes the
T6324 17784-17786 NN denotes WT
T6325 17787-17794 NN denotes control
T6326 17795-17796 -LRB- denotes (
T6327 17796-17800 NNP denotes Fig.
T6328 17801-17803 NN denotes 7B
T6329 17803-17804 -RRB- denotes )
T6330 17804-17805 -COMMA- denotes ,
T6331 17806-17816 VB denotes suggesting
T6332 17817-17827 JJ denotes Th2-skewed
T6333 17828-17842 NN denotes immunogenicity
T6334 17843-17845 IN denotes of
T6335 17846-17850 NN denotes cpdm
T6336 17851-17855 NN denotes BMDC
T6337 17857-17860 DT denotes The
T6338 17861-17871 NN denotes production
T6339 17872-17874 IN denotes of
T6340 17875-17888 JJ denotes Th17-specific
T6341 17889-17897 NN denotes cytokine
T6342 17898-17903 NN denotes IL17A
T6343 17904-17913 VB denotes following
T6344 17914-17917 NN denotes LPS
T6345 17918-17929 NN denotes stimulation
T6346 17930-17932 IN denotes of
T6347 17933-17942 JJ denotes dendritic
T6348 17943-17948 NN denotes cells
T6349 17949-17952 VB denotes was
T6350 17953-17960 JJ denotes similar
T6351 17961-17968 IN denotes between
T6352 17969-17979 VB denotes stimulated
T6353 17980-17982 NN denotes WT
T6354 17983-17986 CC denotes and
T6355 17987-17991 NN denotes cpdm
T6356 17992-17996 NN denotes BMDC
T6357 17997-18007 NN denotes cocultures
T6358 18008-18009 -LRB- denotes (
T6359 18009-18013 NN denotes data
T6360 18014-18017 RB denotes not
T6361 18018-18023 VB denotes shown
T6362 18023-18024 -RRB- denotes )
T6363 18026-18033 IN denotes Despite
T6364 18034-18037 DT denotes the
T6365 18038-18046 JJ denotes distinct
T6366 18047-18051 NN denotes Th1-
T6367 18052-18055 CC denotes and
T6368 18056-18071 JJ denotes Th2-stimulating
T6369 18072-18081 NN denotes abilities
T6370 18082-18084 IN denotes of
T6371 18085-18087 NN denotes WT
T6372 18088-18091 CC denotes and
T6373 18092-18096 NN denotes cpdm
T6374 18097-18101 NN denotes BMDC
T6375 18101-18102 -COMMA- denotes ,
T6376 18103-18107 PRP denotes they
T6377 18108-18112 VB denotes were
T6378 18113-18120 RB denotes equally
T6379 18121-18130 JJ denotes effective
T6380 18131-18133 IN denotes in
T6381 18134-18137 NN denotes IL2
T6382 18138-18148 NN denotes production
T6383 18149-18153 IN denotes from
T6384 18154-18160 NN denotes BMDC-T
T6385 18161-18165 NN denotes cell
T6386 18166-18177 NN denotes co-cultures
T6387 18178-18184 IN denotes except
T6388 18185-18188 IN denotes for
T6389 18189-18193 NN denotes poly
T6390 18194-18195 NN denotes I
T6391 18195-18196 -COLON- denotes :
T6392 18196-18197 NN denotes C
T6393 18198-18209 NN denotes stimulation
T6394 18210-18215 WRB denotes where
T6395 18216-18218 NN denotes WT
T6396 18219-18223 NN denotes BMDC
T6397 18224-18231 VB denotes induced
T6398 18232-18236 JJ denotes more
T6399 18237-18240 NN denotes IL2
T6400 18241-18245 IN denotes than
T6401 18246-18250 NN denotes cpdm
T6402 18251-18255 NN denotes BMDC
T6403 18256-18257 -LRB- denotes (
T6404 18257-18261 NNP denotes Fig.
T6405 18262-18264 NN denotes 7C
T6406 18264-18265 -RRB- denotes )
T6407 18267-18270 DT denotes The
T6408 18271-18281 JJ denotes Th2-biased
T6409 18282-18293 VB denotes stimulating
T6410 18294-18304 NN denotes capability
T6411 18305-18307 IN denotes of
T6412 18308-18312 NN denotes cpdm
T6413 18313-18317 NN denotes BMDC
T6414 18318-18322 WRB denotes when
T6415 18323-18334 VB denotes co-cultured
T6416 18335-18339 IN denotes with
T6417 18340-18350 JJ denotes allogeneic
T6418 18351-18356 NN denotes naïve
T6419 18357-18361 JJ denotes CD4+
T6420 18362-18363 NN denotes T
T6421 18364-18369 NN denotes cells
T6422 18370-18372 VB denotes is
T6423 18373-18383 JJ denotes consistent
T6424 18384-18388 IN denotes with
T6425 18389-18392 DT denotes the
T6426 18393-18405 JJ denotes Th2-dominant
T6427 18406-18414 NN denotes cytokine
T6428 18415-18424 NN denotes phenotype
T6429 18425-18433 VB denotes observed
T6430 18434-18436 IN denotes in
T6431 18437-18441 NN denotes cpdm
T6432 18442-18446 NN denotes mice
T15341 18492-18502 VB denotes Stimulated
T15342 18503-18507 NN denotes cpdm
T15343 18508-18512 NN denotes BMDC
T15344 18513-18520 VB denotes induced
T15345 18521-18531 JJ denotes Th2-biased
T15346 18532-18540 NN denotes cytokine
T15347 18541-18551 NN denotes production
T15348 18552-18556 IN denotes from
T15349 18557-18562 NN denotes naïve
T15350 18563-18567 JJ denotes CD4+
T15351 18568-18569 NN denotes T
T15352 18570-18575 NN denotes cells
T15353 18577-18579 NN denotes WT
T15354 18580-18583 CC denotes and
T15355 18584-18588 NN denotes cpdm
T15356 18589-18593 NN denotes BMDC
T15357 18594-18595 -LRB- denotes (
T15358 18595-18600 CD denotes 5×104
T15359 18601-18606 NN denotes cells
T15360 18607-18609 IN denotes in
T15361 18610-18613 CD denotes 0.1
T15362 18614-18616 NN denotes mL
T15363 18617-18625 JJ denotes complete
T15364 18626-18632 NN denotes medium
T15365 18632-18633 -COLON- denotes ;
T15366 18634-18637 NN denotes MHC
T15367 18638-18647 NN denotes haplotype
T15368 18647-18648 -COLON- denotes :
T15369 18649-18653 NN denotes H-2b
T15370 18653-18654 -RRB- denotes )
T15371 18655-18659 VB denotes were
T15372 18660-18669 VB denotes incubated
T15373 18670-18674 IN denotes with
T15374 18675-18681 NN denotes medium
T15375 18681-18682 -COMMA- denotes ,
T15376 18683-18686 CD denotes 100
T15377 18687-18692 NN denotes ng/mL
T15378 18693-18696 NN denotes LPS
T15379 18696-18697 -COMMA- denotes ,
T15380 18698-18700 CD denotes 25
T15381 18701-18706 NN denotes µg/mL
T15382 18707-18711 NN denotes poly
T15383 18712-18713 NN denotes I
T15384 18713-18714 -COLON- denotes :
T15385 18714-18715 NN denotes C
T15386 18716-18718 CC denotes or
T15387 18719-18720 CD denotes 5
T15388 18721-18726 NN denotes µg/mL
T15389 18727-18734 NN denotes Pam3CYS
T15390 18736-18741 IN denotes After
T15391 18742-18744 CD denotes 24
T15392 18745-18750 NN denotes hours
T15393 18750-18751 -COMMA- denotes ,
T15394 18752-18757 NN denotes cells
T15395 18758-18762 VB denotes were
T15396 18763-18769 VB denotes washed
T15397 18770-18774 IN denotes with
T15398 18775-18778 NNP denotes PBS
T15399 18779-18782 CC denotes and
T15400 18783-18792 VB denotes incubated
T15401 18793-18797 IN denotes with
T15402 18798-18805 RB denotes freshly
T15403 18806-18814 VB denotes isolated
T15404 18815-18825 JJ denotes allogeneic
T15405 18826-18831 NN denotes naïve
T15406 18832-18836 JJ denotes CD4+
T15407 18837-18838 NN denotes T
T15408 18839-18844 NN denotes cells
T15409 18845-18846 -LRB- denotes (
T15410 18846-18853 CD denotes 2.5×105
T15411 18854-18859 NN denotes cells
T15412 18860-18862 IN denotes in
T15413 18863-18866 CD denotes 0.1
T15414 18867-18869 NN denotes mL
T15415 18870-18878 JJ denotes complete
T15416 18879-18885 NN denotes medium
T15417 18885-18886 -COLON- denotes ;
T15418 18887-18890 NN denotes MHC
T15419 18891-18900 NN denotes haplotype
T15420 18900-18901 -COLON- denotes :
T15421 18902-18906 NN denotes H-2d
T15422 18906-18907 -RRB- denotes )
T15423 18909-18914 IN denotes After
T15424 18915-18916 CD denotes 5
T15425 18917-18921 NN denotes days
T15426 18921-18922 -COMMA- denotes ,
T15427 18923-18935 NN denotes supernatants
T15428 18936-18940 VB denotes were
T15429 18941-18950 VB denotes collected
T15430 18951-18954 CC denotes and
T15431 18955-18958 DT denotes the
T15432 18959-18968 NN denotes secretion
T15433 18969-18971 IN denotes of
T15434 18972-18976 NN denotes IFNγ
T15435 18976-18977 -COMMA- denotes ,
T15436 18978-18981 NN denotes IL4
T15437 18981-18982 -COMMA- denotes ,
T15438 18983-18986 CC denotes and
T15439 18987-18990 NN denotes IL2
T15440 18991-18995 VB denotes were
T15441 18996-19004 VB denotes measured
T15442 19005-19007 IN denotes by
T15443 19008-19013 NN denotes ELISA
T15444 19015-19023 JJ denotes Negative
T15445 19024-19032 NN denotes controls
T15446 19033-19036 VB denotes are
T15447 19037-19038 CD denotes 1
T15448 19038-19039 -RRB- denotes )
T15449 19040-19050 VB denotes stimulated
T15450 19051-19055 NN denotes BMDC
T15451 19056-19063 IN denotes without
T15452 19064-19074 NN denotes co-culture
T15453 19075-19079 IN denotes with
T15454 19080-19090 JJ denotes allogeneic
T15455 19091-19095 JJ denotes CD4+
T15456 19096-19097 NN denotes T
T15457 19098-19103 NN denotes cells
T15458 19103-19104 -COLON- denotes ;
T15459 19105-19106 LS denotes 2
T15460 19106-19107 -RRB- denotes )
T15461 19108-19118 JJ denotes allogeneic
T15462 19119-19123 JJ denotes CD4+
T15463 19124-19125 NN denotes T
T15464 19126-19131 NN denotes cells
T15465 19132-19139 IN denotes without
T15466 19140-19150 NN denotes co-culture
T15467 19151-19155 IN denotes with
T15468 19156-19166 VB denotes stimulated
T15469 19167-19171 NN denotes BMDC
T15470 19173-19180 NN denotes Samples
T15471 19181-19185 IN denotes from
T15472 19186-19190 CC denotes both
T15473 19191-19199 JJ denotes negative
T15474 19200-19208 NN denotes controls
T15475 19209-19212 VB denotes had
T15476 19213-19215 DT denotes no
T15477 19216-19226 JJ denotes detectable
T15478 19227-19237 NN denotes production
T15479 19238-19240 IN denotes of
T15480 19241-19244 DT denotes the
T15481 19245-19259 JJ denotes aforementioned
T15482 19260-19269 NN denotes cytokines
T15483 19270-19271 -LRB- denotes (
T15484 19271-19274 RB denotes not
T15485 19275-19280 VB denotes shown
T15486 19280-19281 -RRB- denotes )
T15487 19283-19290 NN denotes Results
T15488 19291-19294 VB denotes are
T15489 19295-19303 VB denotes analyzed
T15490 19304-19309 VB denotes based
T15491 19310-19312 IN denotes on
T15492 19313-19316 CD denotes 2–4
T15493 19317-19321 NN denotes mice
T15494 19322-19325 IN denotes per
T15495 19326-19332 NN denotes group.
T15496 19333-19334 SYM denotes *
T15497 19335-19336 NN denotes P
T15498 19336-19337 SYM denotes <
T15499 19337-19341 CD denotes 0.05
T7942 19355-19358 DT denotes The
T7943 19359-19366 JJ denotes present
T7944 19367-19373 NN denotes report
T7945 19374-19380 VB denotes showed
T7946 19381-19385 IN denotes that
T7947 19386-19390 JJ denotes null
T7948 19391-19400 NN denotes mutations
T7949 19401-19403 IN denotes of
T7950 19404-19407 DT denotes the
T7951 19408-19413 NN denotes mouse
T7952 19414-19421 NN denotes Sharpin
T7953 19422-19426 NN denotes gene
T7954 19427-19430 VB denotes did
T7955 19431-19434 RB denotes not
T7956 19435-19441 VB denotes affect
T7957 19442-19445 DT denotes the
T7958 19446-19458 JJ denotes steady-state
T7959 19459-19471 NN denotes distribution
T7960 19472-19474 IN denotes of
T7961 19475-19482 JJ denotes splenic
T7962 19483-19485 NN denotes DC
T7963 19486-19493 NN denotes subsets
T7964 19494-19497 CC denotes nor
T7965 19498-19501 DT denotes the
T7966 19502-19513 NN denotes development
T7967 19514-19517 CC denotes and
T7968 19518-19527 NN denotes phenotype
T7969 19528-19530 IN denotes of
T7970 19531-19535 NN denotes BMDC
T7971 19537-19544 RB denotes However
T7972 19544-19545 -COMMA- denotes ,
T7973 19546-19550 NN denotes loss
T7974 19551-19553 IN denotes of
T7975 19554-19561 NN denotes SHARPIN
T7976 19562-19575 RB denotes significantly
T7977 19576-19586 VB denotes diminished
T7978 19587-19590 DT denotes the
T7979 19591-19599 NN denotes capacity
T7980 19600-19602 IN denotes of
T7981 19603-19607 NN denotes BMDC
T7982 19608-19610 TO denotes to
T7983 19611-19618 VB denotes secrete
T7984 19619-19631 JJ denotes inflammatory
T7985 19632-19641 NN denotes cytokines
T7986 19642-19645 CC denotes and
T7987 19646-19652 JJ denotes nitric
T7988 19653-19658 NN denotes oxide
T7989 19660-19663 DT denotes The
T7990 19664-19674 VB denotes attenuated
T7991 19675-19683 NN denotes cytokine
T7992 19684-19694 NN denotes production
T7993 19695-19698 VB denotes was
T7994 19699-19702 RB denotes not
T7995 19703-19706 JJ denotes due
T7996 19707-19709 TO denotes to
T7997 19710-19713 DT denotes the
T7998 19714-19722 NN denotes presence
T7999 19723-19725 IN denotes of
T8000 19726-19743 JJ denotes anti-inflammatory
T8001 19744-19754 NN denotes inhibitors
T8002 19754-19755 -COMMA- denotes ,
T8003 19756-19759 CC denotes and
T8004 19760-19763 MD denotes can
T8005 19764-19766 VB denotes be
T8006 19767-19774 RB denotes largely
T8007 19775-19784 VB denotes explained
T8008 19785-19787 IN denotes by
T8009 19788-19797 JJ denotes selective
T8010 19798-19810 NN denotes inactivation
T8011 19811-19813 IN denotes of
T8012 19814-19819 NN denotes NF-κB
T8013 19820-19829 NN denotes signaling
T8014 19831-19841 VB denotes Stimulated
T8015 19842-19846 NN denotes cpdm
T8016 19847-19851 NN denotes BMDC
T8017 19852-19861 VB denotes exhibited
T8018 19862-19872 JJ denotes Th2-biased
T8019 19873-19874 NN denotes T
T8020 19875-19890 JJ denotes cell-polarizing
T8021 19891-19903 NN denotes capabilities
T8022 19903-19904 -COMMA- denotes ,
T8023 19905-19915 JJ denotes consistent
T8024 19916-19920 IN denotes with
T8025 19921-19924 DT denotes the
T8026 19925-19928 NN denotes Th2
T8027 19929-19946 JJ denotes cytokine-dominant
T8028 19947-19956 NN denotes phenotype
T8029 19957-19959 IN denotes in
T8030 19960-19964 NN denotes cpdm
T8031 19965-19969 NN denotes mice
T8032 19971-19979 RB denotes Together
T8033 19979-19980 -COMMA- denotes ,
T8034 19981-19986 DT denotes these
T8035 19987-19994 NN denotes results
T8036 19995-20003 VB denotes indicate
T8037 20004-20006 DT denotes an
T8038 20007-20020 JJ denotes indispensible
T8039 20021-20025 NN denotes role
T8040 20026-20028 IN denotes of
T8041 20029-20036 NN denotes SHARPIN
T8042 20037-20039 IN denotes in
T8043 20040-20050 VB denotes regulating
T8044 20051-20053 NN denotes DC
T8045 20054-20067 JJ denotes immunological
T8046 20068-20077 NN denotes functions
T8047 20077-20078 -COMMA- denotes ,
T8048 20079-20089 NN denotes disruption
T8049 20090-20092 IN denotes of
T8050 20093-20098 WDT denotes which
T8051 20099-20102 MD denotes may
T8052 20103-20113 VB denotes contribute
T8053 20114-20116 TO denotes to
T8054 20117-20120 DT denotes the
T8055 20121-20132 NN denotes development
T8056 20133-20135 IN denotes of
T8057 20136-20142 JJ denotes immune
T8058 20143-20151 NN denotes diseases
T8059 20153-20158 IN denotes Since
T8060 20159-20161 NN denotes WT
T8061 20162-20165 CC denotes and
T8062 20166-20170 NN denotes cpdm
T8063 20171-20175 NN denotes mice
T8064 20176-20179 VB denotes are
T8065 20180-20184 DT denotes both
T8066 20185-20193 JJ denotes specific
T8067 20194-20207 NN denotes pathogen-free
T8068 20207-20208 -COMMA- denotes ,
T8069 20209-20212 DT denotes the
T8070 20213-20219 NN denotes nature
T8071 20220-20222 IN denotes of
T8072 20223-20226 DT denotes the
T8073 20227-20234 NN denotes trigger
T8074 20235-20237 IN denotes of
T8075 20238-20241 DT denotes the
T8076 20242-20248 JJ denotes severe
T8077 20249-20261 NN denotes inflammation
T8078 20262-20264 IN denotes in
T8079 20265-20269 NN denotes cpdm
T8080 20270-20274 NN denotes mice
T8081 20275-20277 VB denotes is
T8082 20278-20281 RB denotes not
T8083 20282-20289 JJ denotes obvious
T8084 20291-20294 CD denotes One
T8085 20295-20299 JJ denotes such
T8086 20300-20310 VB denotes initiating
T8087 20311-20317 NN denotes factor
T8088 20318-20323 MD denotes could
T8089 20324-20326 VB denotes be
T8090 20327-20337 JJ denotes endogenous
T8091 20338-20347 JJ denotes apoptotic
T8092 20348-20354 CC denotes and/or
T8093 20355-20363 JJ denotes necrotic
T8094 20364-20369 NN denotes cells
T8095 20370-20374 WDT denotes that
T8096 20375-20378 MD denotes can
T8097 20379-20386 VB denotes release
T8098 20387-20404 JJ denotes danger-associated
T8099 20405-20414 JJ denotes molecular
T8100 20415-20423 NN denotes patterns
T8101 20424-20425 -LRB- denotes (
T8102 20425-20430 NN denotes DAMPs
T8103 20430-20431 -RRB- denotes )
T8104 20432-20434 TO denotes to
T8105 20435-20441 VB denotes launch
T8106 20442-20445 CC denotes and
T8107 20446-20453 VB denotes amplify
T8108 20454-20456 DT denotes an
T8109 20457-20469 JJ denotes inflammatory
T8110 20470-20478 NN denotes response
T8111 20479-20480 -LRB- denotes [
T8112 20480-20482 CD denotes 32
T8113 20482-20483 -RRB- denotes ]
T8114 20485-20489 JJ denotes Such
T8115 20490-20499 NN denotes ‘sterile’
T8116 20500-20512 NN denotes inflammation
T8117 20513-20518 MD denotes could
T8118 20519-20521 VB denotes be
T8119 20522-20531 VB denotes initiated
T8120 20532-20535 CC denotes and
T8121 20536-20540 VB denotes take
T8122 20541-20546 NN denotes place
T8123 20547-20549 IN denotes in
T8124 20550-20553 DT denotes all
T8125 20554-20560 NN denotes organs
T8126 20561-20564 CC denotes and
T8127 20565-20572 NN denotes tissues
T8128 20573-20581 VB denotes affected
T8129 20582-20584 IN denotes in
T8130 20585-20589 NN denotes cpdm
T8131 20590-20594 NN denotes mice
T8132 20594-20595 -COMMA- denotes ,
T8133 20596-20600 RB denotes thus
T8134 20601-20608 VB denotes causing
T8135 20609-20620 JJ denotes multi-organ
T8136 20621-20633 JJ denotes inflammatory
T8137 20634-20643 NN denotes disorders
T8138 20645-20649 DT denotes This
T8139 20650-20660 NN denotes hypothesis
T8140 20661-20663 VB denotes is
T8141 20664-20673 VB denotes supported
T8142 20674-20676 IN denotes by
T8143 20677-20684 JJ denotes several
T8144 20685-20691 JJ denotes recent
T8145 20692-20699 NN denotes studies
T8146 20701-20712 NN denotes Fibroblasts
T8147 20713-20715 IN denotes of
T8148 20716-20720 NN denotes cpdm
T8149 20721-20725 NN denotes mice
T8150 20726-20729 VB denotes are
T8151 20730-20736 RB denotes highly
T8152 20737-20746 JJ denotes sensitive
T8153 20747-20749 TO denotes to
T8154 20750-20762 JJ denotes TNFα-induced
T8155 20763-20767 NN denotes cell
T8156 20768-20773 NN denotes death
T8157 20774-20777 CC denotes and
T8158 20778-20781 DT denotes the
T8159 20782-20786 NN denotes cpdm
T8160 20787-20796 NN denotes phenotype
T8161 20797-20800 MD denotes can
T8162 20801-20803 VB denotes be
T8163 20804-20813 RB denotes partially
T8164 20814-20821 VB denotes rescued
T8165 20822-20824 IN denotes by
T8166 20825-20833 NN denotes deletion
T8167 20834-20836 IN denotes of
T8168 20837-20840 NN denotes TNF
T8169 20841-20842 -LRB- denotes [
T8170 20842-20843 CD denotes 7
T8171 20843-20844 -RRB- denotes ]
T8172 20844-20845 -COMMA- denotes ,
T8173 20846-20847 -LRB- denotes [
T8174 20847-20848 CD denotes 8
T8175 20848-20849 -RRB- denotes ]
T8176 20849-20850 -COMMA- denotes ,
T8177 20851-20861 VB denotes suggesting
T8178 20862-20866 IN denotes that
T8179 20867-20877 NN denotes deficiency
T8180 20878-20880 IN denotes of
T8181 20881-20888 NN denotes SHARPIN
T8182 20889-20900 VB denotes compromises
T8183 20901-20904 DT denotes the
T8184 20905-20919 JJ denotes anti-apoptotic
T8185 20920-20930 NN denotes mechanisms
T8186 20931-20933 IN denotes in
T8187 20934-20938 NN denotes cpdm
T8188 20939-20943 NN denotes mice
T8189 20944-20953 VB denotes resulting
T8190 20954-20956 IN denotes in
T8191 20957-20961 NN denotes cell
T8192 20962-20975 JJ denotes death-induced
T8193 20976-20988 JJ denotes inflammatory
T8194 20989-20996 NN denotes disease
T8195 20998-21007 NN denotes Apoptosis
T8196 21008-21010 IN denotes of
T8197 21011-21024 NN denotes keratinocytes
T8198 21025-21027 VB denotes is
T8199 21028-21029 DT denotes a
T8200 21030-21039 JJ denotes prominent
T8201 21040-21047 NN denotes feature
T8202 21048-21050 IN denotes of
T8203 21051-21054 DT denotes the
T8204 21055-21059 NN denotes skin
T8205 21060-21067 NN denotes lesions
T8206 21068-21070 IN denotes in
T8207 21071-21075 NN denotes cpdm
T8208 21076-21080 NN denotes mice
T8209 21081-21082 -LRB- denotes [
T8210 21082-21084 CD denotes 33
T8211 21084-21085 -RRB- denotes ]
T8212 21086-21089 CC denotes and
T8213 21090-21094 DT denotes this
T8214 21095-21097 VB denotes is
T8215 21098-21106 VB denotes mediated
T8216 21107-21109 IN denotes by
T8217 21110-21127 JJ denotes caspase-dependent
T8218 21128-21141 JJ denotes mitochondrial
T8219 21142-21150 NN denotes pathways
T8220 21151-21152 -LRB- denotes [
T8221 21152-21154 CD denotes 34
T8222 21154-21155 -RRB- denotes ]
T8223 21157-21162 DT denotes These
T8224 21163-21170 VB denotes induced
T8225 21171-21177 CC denotes and/or
T8226 21178-21187 JJ denotes intrinsic
T8227 21188-21197 JJ denotes apoptotic
T8228 21198-21203 NN denotes cells
T8229 21204-21207 MD denotes can
T8230 21208-21215 VB denotes release
T8231 21216-21223 JJ denotes various
T8232 21224-21229 NN denotes types
T8233 21230-21232 IN denotes of
T8234 21233-21238 NN denotes DAMPs
T8235 21239-21243 WDT denotes that
T8236 21244-21249 VB denotes exert
T8237 21250-21255 PRP-DOLLAR- denotes their
T8238 21256-21272 JJ denotes pro-inflammatory
T8239 21273-21283 NN denotes properties
T8240 21284-21286 IN denotes by
T8241 21287-21297 VB denotes activating
T8242 21298-21300 NN denotes DC
T8243 21301-21308 IN denotes through
T8244 21309-21316 NN denotes pattern
T8245 21317-21328 NN denotes recognition
T8246 21329-21338 NN denotes receptors
T8247 21339-21340 -LRB- denotes [
T8248 21340-21342 CD denotes 32
T8249 21342-21343 -RRB- denotes ]
T8250 21343-21344 -COMMA- denotes ,
T8251 21345-21346 -LRB- denotes [
T8252 21346-21348 CD denotes 35
T8253 21348-21349 -RRB- denotes ]
T8254 21349-21350 -COMMA- denotes ,
T8255 21351-21355 JJ denotes such
T8256 21356-21358 IN denotes as
T8257 21359-21364 NN denotes HMGB1
T8258 21365-21375 VB denotes recognized
T8259 21376-21378 IN denotes by
T8260 21379-21385 NN denotes TLR2/4
T8261 21386-21387 -LRB- denotes [
T8262 21387-21389 CD denotes 36
T8263 21389-21390 -RRB- denotes ]
T8264 21390-21391 -COMMA- denotes ,
T8265 21392-21393 -LRB- denotes [
T8266 21393-21395 CD denotes 37
T8267 21395-21396 -RRB- denotes ]
T8268 21398-21408 JJ denotes Consistent
T8269 21409-21413 IN denotes with
T8270 21414-21417 DT denotes the
T8271 21418-21426 JJ denotes impaired
T8272 21427-21430 NN denotes Th1
T8273 21431-21437 JJ denotes immune
T8274 21438-21446 NN denotes response
T8275 21447-21449 IN denotes in
T8276 21450-21454 NN denotes cpdm
T8277 21455-21459 NN denotes mice
T8278 21460-21461 -LRB- denotes [
T8279 21461-21462 CD denotes 5
T8280 21462-21463 -RRB- denotes ]
T8281 21463-21464 -COMMA- denotes ,
T8282 21465-21475 VB denotes stimulated
T8283 21476-21480 NN denotes BMDC
T8284 21481-21487 RB denotes weakly
T8285 21488-21497 VB denotes polarized
T8286 21498-21501 NN denotes Th1
T8287 21502-21517 NN denotes differentiation
T8288 21517-21518 -COMMA- denotes ,
T8289 21519-21522 CC denotes but
T8290 21523-21531 RB denotes strongly
T8291 21532-21541 VB denotes supported
T8292 21542-21545 DT denotes the
T8293 21546-21557 NN denotes development
T8294 21558-21560 IN denotes of
T8295 21561-21564 NN denotes Th2
T8296 21565-21573 NN denotes effector
T8297 21574-21579 NN denotes cells
T8298 21581-21589 VB denotes Combined
T8299 21590-21594 IN denotes with
T8300 21595-21598 DT denotes the
T8301 21599-21607 JJ denotes dramatic
T8302 21608-21614 NN denotes effect
T8303 21615-21617 IN denotes of
T8304 21618-21622 NN denotes IL12
T8305 21623-21632 NN denotes treatment
T8306 21633-21635 IN denotes on
T8307 21636-21639 DT denotes the
T8308 21640-21649 NN denotes phenotype
T8309 21650-21652 IN denotes of
T8310 21653-21658 DT denotes these
T8311 21659-21663 NN denotes mice
T8312 21664-21665 -LRB- denotes [
T8313 21665-21666 CD denotes 5
T8314 21666-21667 -RRB- denotes ]
T8315 21667-21668 -COMMA- denotes ,
T8316 21669-21673 DT denotes this
T8317 21674-21682 VB denotes suggests
T8318 21683-21687 IN denotes that
T8319 21688-21691 DT denotes the
T8320 21692-21702 JJ denotes Th2-biased
T8321 21703-21711 JJ denotes systemic
T8322 21712-21724 NN denotes inflammation
T8323 21725-21727 IN denotes in
T8324 21728-21732 NN denotes cpdm
T8325 21733-21737 NN denotes mice
T8326 21738-21740 VB denotes is
T8327 21741-21747 VB denotes caused
T8328 21748-21750 IN denotes by
T8329 21751-21758 VB denotes reduced
T8330 21759-21766 NN denotes IL12P70
T8331 21767-21777 NN denotes production
T8332 21778-21782 IN denotes from
T8333 21783-21785 NN denotes DC
T8334 21787-21790 DT denotes The
T8335 21791-21801 NN denotes importance
T8336 21802-21804 IN denotes of
T8337 21805-21812 NN denotes IL12P70
T8338 21813-21815 IN denotes in
T8339 21816-21826 VB denotes regulating
T8340 21827-21830 NN denotes Th1
T8341 21831-21834 CC denotes and
T8342 21835-21838 NN denotes Th2
T8343 21839-21845 JJ denotes immune
T8344 21846-21855 NN denotes responses
T8345 21856-21858 IN denotes in
T8346 21859-21863 NN denotes mice
T8347 21864-21867 VB denotes was
T8348 21868-21875 RB denotes clearly
T8349 21876-21888 VB denotes demonstrated
T8350 21889-21891 IN denotes in
T8351 21892-21900 NN denotes IL12P35-
T8352 21901-21904 CC denotes and
T8353 21905-21922 JJ denotes IL12P40-deficient
T8354 21923-21927 NN denotes mice
T8355 21928-21929 -LRB- denotes [
T8356 21929-21931 CD denotes 38
T8357 21931-21932 -RRB- denotes ]
T8358 21932-21933 -COMMA- denotes ,
T8359 21934-21935 -LRB- denotes [
T8360 21935-21937 CD denotes 39
T8361 21937-21938 -RRB- denotes ]
T8362 21939-21942 CC denotes and
T8363 21943-21950 IN denotes through
T8364 21951-21959 JJ denotes clinical
T8365 21960-21967 NN denotes studies
T8366 21968-21970 IN denotes in
T8367 21971-21976 JJ denotes human
T8368 21977-21985 NN denotes patients
T8369 21986-21987 -LRB- denotes [
T8370 21987-21989 CD denotes 40
T8371 21989-21990 -RRB- denotes ]
T8372 21990-21991 CD denotes –
T8373 21991-21992 -LRB- denotes [
T8374 21992-21994 CD denotes 42
T8375 21994-21995 -RRB- denotes ]
T8376 21997-22002 NN denotes NF-κB
T8377 22002-22003 -COMMA- denotes ,
T8378 22004-22012 NN denotes TBK/IRF3
T8379 22012-22013 -COMMA- denotes ,
T8380 22014-22017 CC denotes and
T8381 22018-22022 NN denotes MAPK
T8382 22023-22032 NN denotes signaling
T8383 22033-22036 VB denotes are
T8384 22037-22046 JJ denotes important
T8385 22047-22055 NN denotes pathways
T8386 22056-22065 VB denotes activated
T8387 22066-22068 IN denotes by
T8388 22069-22072 NN denotes LPS
T8389 22073-22075 CC denotes or
T8390 22076-22080 NN denotes poly
T8391 22081-22082 NN denotes I
T8392 22082-22083 -COLON- denotes :
T8393 22083-22084 NN denotes C
T8394 22085-22088 CC denotes and
T8395 22089-22099 NN denotes disruption
T8396 22100-22102 IN denotes of
T8397 22103-22109 DT denotes either
T8398 22110-22117 NN denotes pathway
T8399 22118-22121 MD denotes may
T8400 22122-22126 VB denotes lead
T8401 22127-22129 TO denotes to
T8402 22130-22139 VB denotes decreased
T8403 22140-22148 NN denotes cytokine
T8404 22149-22159 NN denotes expression
T8405 22161-22166 NN denotes NF-κB
T8406 22167-22177 NN denotes activation
T8407 22178-22181 VB denotes was
T8408 22182-22193 RB denotes selectively
T8409 22194-22203 VB denotes inhibited
T8410 22204-22206 IN denotes in
T8411 22207-22210 NN denotes LPS
T8412 22211-22214 CC denotes and
T8413 22215-22219 NN denotes poly
T8414 22220-22221 NN denotes I
T8415 22221-22222 SYM denotes :
T8416 22222-22223 NN denotes C
T8417 22224-22234 VB denotes stimulated
T8418 22235-22239 NN denotes cpdm
T8419 22240-22244 NN denotes BMDC
T8420 22245-22253 VB denotes compared
T8421 22254-22256 TO denotes to
T8422 22257-22261 JJ denotes wild
T8423 22262-22266 NN denotes type
T8424 22266-22267 -COMMA- denotes ,
T8425 22268-22273 IN denotes while
T8426 22274-22284 NN denotes activation
T8427 22285-22287 IN denotes of
T8428 22288-22297 NN denotes TBK1/IRF3
T8429 22297-22298 -COMMA- denotes ,
T8430 22299-22305 NN denotes ERK1/2
T8431 22305-22306 -COMMA- denotes ,
T8432 22307-22309 CC denotes or
T8433 22310-22313 NN denotes p38
T8434 22314-22317 VB denotes was
T8435 22318-22321 RB denotes not
T8436 22321-22322 -COMMA- denotes ,
T8437 22323-22333 VB denotes indicating
T8438 22334-22338 IN denotes that
T8439 22339-22348 VB denotes disrupted
T8440 22349-22354 NN denotes NF-κB
T8441 22355-22364 NN denotes signaling
T8442 22365-22367 IN denotes in
T8443 22368-22372 NN denotes cpdm
T8444 22373-22375 NN denotes DC
T8445 22376-22378 VB denotes is
T8446 22379-22390 JJ denotes responsible
T8447 22391-22394 IN denotes for
T8448 22395-22398 DT denotes the
T8449 22399-22408 JJ denotes defective
T8450 22409-22417 NN denotes cytokine
T8451 22418-22428 NN denotes expression
T8452 22430-22435 DT denotes These
T8453 22436-22443 NN denotes results
T8454 22444-22448 VB denotes seem
T8455 22449-22451 TO denotes to
T8456 22452-22462 VB denotes contradict
T8457 22463-22464 DT denotes a
T8458 22465-22471 JJ denotes recent
T8459 22472-22477 NN denotes study
T8460 22478-22482 WDT denotes that
T8461 22483-22488 VB denotes found
T8462 22489-22498 VB denotes increased
T8463 22499-22505 NN denotes levels
T8464 22506-22508 IN denotes of
T8465 22509-22514 NN denotes NF-κB
T8466 22515-22525 NN denotes activation
T8467 22526-22529 CC denotes and
T8468 22530-22533 NN denotes IL1
T8469 22534-22547 NN denotes transcription
T8470 22548-22550 IN denotes in
T8471 22551-22555 NN denotes cpdm
T8472 22556-22560 NN denotes mice
T8473 22561-22562 -LRB- denotes [
T8474 22562-22564 CD denotes 43
T8475 22564-22565 -RRB- denotes ]
T8476 22567-22571 DT denotes This
T8477 22572-22582 NN denotes difference
T8478 22583-22586 MD denotes can
T8479 22587-22595 RB denotes probably
T8480 22596-22598 VB denotes be
T8481 22599-22609 VB denotes attributed
T8482 22610-22612 TO denotes to
T8483 22613-22616 DT denotes the
T8484 22617-22626 JJ denotes different
T8485 22627-22632 NN denotes cells
T8486 22633-22636 CC denotes and
T8487 22637-22644 NN denotes tissues
T8488 22645-22649 VB denotes used
T8489 22650-22652 IN denotes in
T8490 22653-22658 DT denotes these
T8491 22659-22666 NN denotes studies
T8492 22666-22667 -COMMA- denotes ,
T8493 22668-22671 CC denotes and
T8494 22672-22675 MD denotes may
T8495 22676-22681 VB denotes point
T8496 22682-22684 TO denotes to
T8497 22685-22690 NN denotes cell-
T8498 22691-22694 CC denotes and
T8499 22695-22702 NN denotes tissue-
T8500 22703-22707 NN denotes type
T8501 22708-22716 JJ denotes specific
T8502 22717-22726 NN denotes functions
T8503 22727-22729 IN denotes of
T8504 22730-22737 NN denotes SHARPIN
T8505 22739-22743 DT denotes This
T8506 22744-22746 VB denotes is
T8507 22747-22757 JJ denotes consistent
T8508 22758-22762 IN denotes with
T8509 22763-22769 JJ denotes recent
T8510 22770-22777 NN denotes reports
T8511 22778-22780 IN denotes of
T8512 22781-22796 JJ denotes tissue-specific
T8513 22797-22804 NN denotes effects
T8514 22805-22807 IN denotes of
T8515 22808-22813 NN denotes NF-κB
T8516 22814-22823 NN denotes signaling
T8517 22824-22825 -LRB- denotes [
T8518 22825-22827 CD denotes 44
T8519 22827-22828 -RRB- denotes ]
T8520 22830-22840 JJ denotes Ubiquitous
T8521 22841-22851 NN denotes activation
T8522 22852-22854 IN denotes of
T8523 22855-22860 NN denotes NF-κB
T8524 22861-22863 IN denotes by
T8525 22864-22872 VB denotes removing
T8526 22873-22883 NN denotes inhibitors
T8527 22884-22888 JJ denotes such
T8528 22889-22891 IN denotes as
T8529 22892-22895 NN denotes A20
T8530 22896-22899 CC denotes and
T8531 22900-22904 NN denotes ITCH
T8532 22905-22912 IN denotes through
T8533 22913-22920 JJ denotes genetic
T8534 22921-22933 NN denotes manipulation
T8535 22934-22941 VB denotes results
T8536 22942-22944 IN denotes in
T8537 22945-22955 JJ denotes widespread
T8538 22956-22968 NN denotes inflammation
T8539 22968-22969 -COMMA- denotes ,
T8540 22970-22980 JJ denotes consistent
T8541 22981-22985 IN denotes with
T8542 22986-22989 DT denotes the
T8543 22990-22994 NN denotes role
T8544 22995-22997 IN denotes of
T8545 22998-23003 NN denotes NF-κB
T8546 23004-23006 IN denotes in
T8547 23007-23010 DT denotes the
T8548 23011-23021 NN denotes production
T8549 23022-23024 IN denotes of
T8550 23025-23041 JJ denotes pro-inflammatory
T8551 23042-23051 NN denotes mediators
T8552 23052-23053 -LRB- denotes [
T8553 23053-23055 CD denotes 45
T8554 23055-23056 -RRB- denotes ]
T8555 23056-23057 -COMMA- denotes ,
T8556 23058-23059 -LRB- denotes [
T8557 23059-23061 CD denotes 46
T8558 23061-23062 -RRB- denotes ]
T8559 23064-23071 RB denotes However
T8560 23071-23072 -COMMA- denotes ,
T8561 23073-23082 JJ denotes selective
T8562 23083-23093 NN denotes inhibition
T8563 23094-23096 IN denotes of
T8564 23097-23102 NN denotes NF-κB
T8565 23103-23113 NN denotes activation
T8566 23114-23116 IN denotes in
T8567 23117-23128 JJ denotes parenchymal
T8568 23129-23134 NN denotes cells
T8569 23135-23137 IN denotes of
T8570 23138-23141 DT denotes the
T8571 23142-23146 NN denotes skin
T8572 23146-23147 -COMMA- denotes ,
T8573 23148-23153 NN denotes liver
T8574 23153-23154 -COMMA- denotes ,
T8575 23155-23158 CC denotes and
T8576 23159-23168 NN denotes intestine
T8577 23169-23176 VB denotes results
T8578 23177-23179 IN denotes in
T8579 23180-23187 JJ denotes chronic
T8580 23188-23200 NN denotes inflammation
T8581 23201-23207 VB denotes driven
T8582 23208-23210 IN denotes by
T8583 23211-23216 NN denotes NF-κB
T8584 23217-23226 JJ denotes competent
T8585 23227-23237 NN denotes leukocytes
T8586 23238-23239 -LRB- denotes [
T8587 23239-23241 CD denotes 47
T8588 23241-23242 -RRB- denotes ]
T8589 23242-23243 CD denotes –
T8590 23243-23244 -LRB- denotes [
T8591 23244-23246 CD denotes 50
T8592 23246-23247 -RRB- denotes ]
T8593 23249-23253 DT denotes This
T8594 23254-23263 VB denotes indicates
T8595 23264-23268 IN denotes that
T8596 23269-23270 DT denotes a
T8597 23271-23278 NN denotes balance
T8598 23279-23286 IN denotes between
T8599 23287-23290 DT denotes the
T8600 23291-23307 JJ denotes pro-inflammatory
T8601 23308-23312 NN denotes role
T8602 23313-23315 IN denotes of
T8603 23316-23321 NN denotes NF-κB
T8604 23322-23324 IN denotes in
T8605 23325-23335 NN denotes leukocytes
T8606 23336-23339 CC denotes and
T8607 23340-23343 DT denotes the
T8608 23344-23361 JJ denotes anti-inflammatory
T8609 23362-23366 NN denotes role
T8610 23367-23369 IN denotes in
T8611 23370-23381 JJ denotes parenchymal
T8612 23382-23387 NN denotes cells
T8613 23388-23390 VB denotes is
T8614 23391-23399 JJ denotes critical
T8615 23400-23402 IN denotes in
T8616 23403-23406 DT denotes the
T8617 23407-23418 NN denotes maintenance
T8618 23419-23421 IN denotes of
T8619 23422-23428 NN denotes tissue
T8620 23429-23440 NN denotes homeostasis
T8621 23442-23453 NN denotes Experiments
T8622 23454-23458 IN denotes with
T8623 23459-23463 NN denotes mice
T8624 23464-23468 IN denotes with
T8625 23469-23474 NN denotes cell-
T8626 23475-23478 CC denotes and
T8627 23479-23494 JJ denotes tissue-specific
T8628 23495-23503 NN denotes deletion
T8629 23504-23506 IN denotes of
T8630 23507-23514 NNP denotes Sharpin
T8631 23514-23515 -COMMA- denotes ,
T8632 23516-23525 RB denotes currently
T8633 23526-23531 IN denotes under
T8634 23532-23535 NN denotes way
T8635 23535-23536 -COMMA- denotes ,
T8636 23537-23541 MD denotes will
T8637 23542-23546 VB denotes help
T8638 23547-23549 TO denotes to
T8639 23550-23559 VB denotes elucidate
T8640 23560-23563 DT denotes the
T8641 23564-23568 NN denotes role
T8642 23569-23571 IN denotes of
T8643 23572-23579 NN denotes SHARPIN
T8644 23580-23582 IN denotes in
T8645 23583-23595 NN denotes inflammation
T8646 23597-23604 IN denotes Despite
T8647 23605-23614 JJ denotes defective
T8648 23615-23620 NN denotes NF-κB
T8649 23621-23631 NN denotes activation
T8650 23632-23634 IN denotes in
T8651 23635-23638 DT denotes the
T8652 23639-23646 NN denotes absence
T8653 23647-23649 IN denotes of
T8654 23650-23657 NN denotes Sharpin
T8655 23658-23668 NN denotes expression
T8656 23668-23669 -COMMA- denotes ,
T8657 23670-23675 EX denotes there
T8658 23676-23679 VB denotes was
T8659 23680-23682 DT denotes no
T8660 23683-23694 JJ denotes significant
T8661 23695-23701 NN denotes change
T8662 23702-23704 IN denotes in
T8663 23705-23712 JJ denotes splenic
T8664 23713-23715 NN denotes DC
T8665 23716-23727 NN denotes populations
T8666 23728-23730 CC denotes or
T8667 23731-23741 NN denotes expression
T8668 23742-23744 IN denotes of
T8669 23745-23759 JJ denotes co-stimulatory
T8670 23760-23769 NN denotes molecules
T8671 23770-23772 IN denotes on
T8672 23773-23777 NN denotes BMDC
T8673 23779-23788 JJ denotes Different
T8674 23789-23794 NN denotes NF-κB
T8675 23795-23803 NN denotes subunits
T8676 23804-23812 VB denotes involved
T8677 23813-23815 IN denotes in
T8678 23816-23819 DT denotes the
T8679 23820-23829 JJ denotes canonical
T8680 23830-23833 CC denotes and
T8681 23834-23847 JJ denotes non-canonical
T8682 23848-23856 NN denotes branches
T8683 23857-23859 IN denotes of
T8684 23860-23863 DT denotes the
T8685 23864-23869 NN denotes NF-κB
T8686 23870-23879 NN denotes signaling
T8687 23880-23887 NN denotes pathway
T8688 23888-23892 VB denotes have
T8689 23893-23901 JJ denotes distinct
T8690 23902-23911 NN denotes functions
T8691 23912-23914 TO denotes to
T8692 23915-23922 VB denotes control
T8693 23923-23931 JJ denotes specific
T8694 23932-23939 NN denotes aspects
T8695 23940-23942 IN denotes of
T8696 23943-23945 NN denotes DC
T8697 23946-23957 NN denotes development
T8698 23958-23961 CC denotes and
T8699 23962-23970 NN denotes function
T8700 23971-23972 -LRB- denotes [
T8701 23972-23974 CD denotes 51
T8702 23974-23975 -RRB- denotes ]
T8703 23975-23976 -COMMA- denotes ,
T8704 23977-23978 -LRB- denotes [
T8705 23978-23980 CD denotes 52
T8706 23980-23981 -RRB- denotes ]
T8707 23983-23986 DT denotes The
T8708 23987-24000 JJ denotes non-canonical
T8709 24001-24008 NN denotes pathway
T8710 24009-24010 -LRB- denotes (
T8711 24010-24014 NN denotes p100
T8712 24015-24025 NN denotes processing
T8713 24026-24028 TO denotes to
T8714 24029-24036 VB denotes produce
T8715 24037-24040 NN denotes p52
T8716 24040-24041 -RRB- denotes )
T8717 24042-24049 VB denotes appears
T8718 24050-24052 TO denotes to
T8719 24053-24055 VB denotes be
T8720 24056-24062 JJ denotes intact
T8721 24063-24065 IN denotes in
T8722 24066-24083 JJ denotes SHARPIN-deficient
T8723 24084-24089 NN denotes cells
T8724 24090-24091 -LRB- denotes [
T8725 24091-24092 CD denotes 7
T8726 24092-24093 -RRB- denotes ]
T8727 24093-24094 -COMMA- denotes ,
T8728 24095-24096 -LRB- denotes [
T8729 24096-24097 CD denotes 9
T8730 24097-24098 -RRB- denotes ]
T8731 24099-24109 VB denotes suggesting
T8732 24110-24114 IN denotes that
T8733 24115-24118 DT denotes the
T8734 24119-24124 NN denotes NF-κB
T8735 24125-24136 NN denotes heterodimer
T8736 24137-24145 NN denotes p52/RELB
T8737 24146-24148 VB denotes is
T8738 24149-24159 JJ denotes sufficient
T8739 24160-24162 TO denotes to
T8740 24163-24171 VB denotes maintain
T8741 24172-24175 DT denotes the
T8742 24176-24182 JJ denotes normal
T8743 24183-24193 NN denotes regulation
T8744 24194-24196 IN denotes of
T8745 24197-24199 NN denotes DC
T8746 24200-24211 NN denotes homeostasis
T8747 24212-24215 CC denotes and
T8748 24216-24226 NN denotes maturation
T8749 24228-24231 DT denotes The
T8750 24232-24241 JJ denotes molecular
T8751 24242-24247 NN denotes basis
T8752 24248-24250 IN denotes by
T8753 24251-24256 WDT denotes which
T8754 24257-24260 DT denotes the
T8755 24261-24268 NNP denotes Sharpin
T8756 24269-24277 NN denotes mutation
T8757 24278-24284 VB denotes causes
T8758 24285-24292 VB denotes reduced
T8759 24293-24298 NN denotes NF-κB
T8760 24299-24309 NN denotes activation
T8761 24310-24312 IN denotes in
T8762 24313-24317 NN denotes BMDC
T8763 24318-24325 VB denotes remains
T8764 24326-24328 TO denotes to
T8765 24329-24331 VB denotes be
T8766 24332-24342 VB denotes determined
T8767 24344-24347 NN denotes LPS
T8768 24348-24351 CC denotes and
T8769 24352-24356 NN denotes poly
T8770 24357-24358 NN denotes I
T8771 24358-24359 -COLON- denotes :
T8772 24359-24360 NN denotes C
T8773 24361-24365 VB denotes used
T8774 24366-24370 RB denotes here
T8775 24371-24374 VB denotes are
T8776 24375-24387 JJ denotes well-defined
T8777 24388-24395 NN denotes ligands
T8778 24396-24400 WDT denotes that
T8779 24401-24413 RB denotes specifically
T8780 24414-24420 VB denotes engage
T8781 24421-24425 NN denotes TLR4
T8782 24426-24429 CC denotes and
T8783 24430-24434 NN denotes TLR3
T8784 24434-24435 -COMMA- denotes ,
T8785 24436-24448 RB denotes respectively
T8786 24450-24453 DT denotes The
T8787 24454-24464 NN denotes expression
T8788 24465-24472 NN denotes profile
T8789 24473-24475 IN denotes of
T8790 24476-24483 NN denotes surface
T8791 24484-24488 NN denotes TLR4
T8792 24489-24498 NN denotes complexes
T8793 24499-24501 VB denotes is
T8794 24502-24509 JJ denotes similar
T8795 24510-24517 IN denotes between
T8796 24518-24520 NN denotes WT
T8797 24521-24524 CC denotes and
T8798 24525-24529 NN denotes cpdm
T8799 24530-24534 NN denotes BMDC
T8800 24535-24545 VB denotes suggesting
T8801 24546-24550 IN denotes that
T8802 24551-24560 JJ denotes defective
T8803 24561-24566 NN denotes NF-κB
T8804 24567-24577 NN denotes activation
T8805 24578-24580 VB denotes is
T8806 24581-24584 RB denotes not
T8807 24585-24586 DT denotes a
T8808 24587-24593 NN denotes result
T8809 24594-24596 IN denotes of
T8810 24597-24609 JJ denotes differential
T8811 24610-24613 NN denotes TLR
T8812 24614-24624 NN denotes expression
T8813 24625-24627 IN denotes on
T8814 24628-24634 NN denotes target
T8815 24635-24640 NN denotes cells
T8816 24642-24645 NN denotes LPS
T8817 24646-24653 VB denotes engages
T8818 24654-24658 NN denotes TLR4
T8819 24659-24661 TO denotes to
T8820 24662-24670 VB denotes activate
T8821 24671-24686 JJ denotes MYD88-dependent
T8822 24687-24690 CC denotes and
T8823 24691-24705 JJ denotes TRIF-dependent
T8824 24706-24714 NN denotes pathways
T8825 24714-24715 -COMMA- denotes ,
T8826 24716-24723 IN denotes whereas
T8827 24724-24728 NN denotes TLR3
T8828 24729-24739 VB denotes stimulated
T8829 24740-24742 IN denotes by
T8830 24743-24747 NN denotes poly
T8831 24748-24749 NN denotes I
T8832 24749-24750 -COLON- denotes :
T8833 24750-24751 NN denotes C
T8834 24752-24756 RB denotes only
T8835 24757-24765 VB denotes triggers
T8836 24766-24780 JJ denotes TRIF-dependent
T8837 24781-24790 NN denotes signaling
T8838 24791-24792 -LRB- denotes [
T8839 24792-24794 CD denotes 53
T8840 24794-24795 -RRB- denotes ]
T8841 24797-24800 DT denotes The
T8842 24801-24810 JJ denotes defective
T8843 24811-24816 NN denotes NF-κB
T8844 24817-24827 NN denotes activation
T8845 24828-24830 IN denotes by
T8846 24831-24835 DT denotes both
T8847 24836-24843 NN denotes stimuli
T8848 24844-24852 VB denotes suggests
T8849 24853-24857 IN denotes that
T8850 24858-24861 DT denotes the
T8851 24862-24869 NNP denotes Sharpin
T8852 24870-24878 NN denotes mutation
T8853 24879-24889 VB denotes interferes
T8854 24890-24894 IN denotes with
T8855 24895-24898 DT denotes the
T8856 24899-24906 NN denotes protein
T8857 24907-24915 NN denotes adaptors
T8858 24916-24918 CC denotes or
T8859 24919-24926 NN denotes kinases
T8860 24927-24933 VB denotes shared
T8861 24934-24936 IN denotes by
T8862 24937-24941 CC denotes both
T8863 24942-24951 NN denotes signaling
T8864 24952-24960 NN denotes pathways
T8865 24960-24961 -COMMA- denotes ,
T8866 24962-24966 JJ denotes such
T8867 24967-24969 IN denotes as
T8868 24970-24974 NN denotes RIP1
T8869 24975-24978 CC denotes and
T8870 24979-24984 NN denotes TRAF6
T8871 24985-24986 -LRB- denotes [
T8872 24986-24988 CD denotes 18
T8873 24988-24989 -RRB- denotes ]
T8874 24991-24997 JJ denotes Recent
T8875 24998-25005 NN denotes studies
T8876 25006-25018 VB denotes demonstrated
T8877 25019-25023 IN denotes that
T8878 25024-25031 NN denotes SHARPIN
T8879 25032-25041 VB denotes interacts
T8880 25042-25046 IN denotes with
T8881 25047-25051 NN denotes HOIP
T8882 25052-25054 TO denotes to
T8883 25055-25059 VB denotes form
T8884 25060-25065 NN denotes LUBAC
T8885 25066-25070 WDT denotes that
T8886 25071-25077 VB denotes exerts
T8887 25078-25081 PRP-DOLLAR- denotes its
T8888 25082-25111 NN denotes linear-ubiquitin-chain-ligase
T8889 25112-25120 NN denotes activity
T8890 25121-25123 IN denotes on
T8891 25124-25129 NN denotes NF-κB
T8892 25130-25139 NN denotes signaling
T8893 25140-25147 NN denotes players
T8894 25148-25152 NN denotes RIP1
T8895 25153-25156 CC denotes and
T8896 25157-25161 NN denotes NEMO
T8897 25162-25163 -LRB- denotes [
T8898 25163-25164 CD denotes 7
T8899 25164-25165 -RRB- denotes ]
T8900 25165-25166 -COMMA- denotes ,
T8901 25167-25169 DT denotes an
T8902 25170-25179 JJ denotes essential
T8903 25180-25184 NN denotes step
T8904 25185-25188 IN denotes for
T8905 25189-25195 JJ denotes intact
T8906 25196-25211 JJ denotes TNFα-stimulated
T8907 25212-25217 NN denotes NF-κB
T8908 25218-25228 NN denotes activation
T8909 25230-25233 DT denotes The
T8910 25234-25241 NNP denotes Sharpin
T8911 25242-25246 JJ denotes null
T8912 25247-25255 NN denotes mutation
T8913 25256-25264 VB denotes disrupts
T8914 25265-25268 DT denotes the
T8915 25269-25283 NN denotes ubiquitylation
T8916 25284-25291 NN denotes process
T8917 25292-25295 CC denotes and
T8918 25296-25305 VB denotes abrogates
T8919 25306-25309 DT denotes the
T8920 25310-25322 JJ denotes TNFα-induced
T8921 25323-25328 NN denotes NF-κB
T8922 25329-25338 NN denotes signaling
T8923 25339-25346 NN denotes pathway
T8924 25348-25353 IN denotes Since
T8925 25354-25358 NN denotes TNFR
T8926 25359-25362 CC denotes and
T8927 25363-25366 NN denotes TLR
T8928 25367-25376 RB denotes partially
T8929 25377-25382 VB denotes share
T8930 25383-25388 PRP-DOLLAR- denotes their
T8931 25389-25399 JJ denotes downstream
T8932 25400-25409 NN denotes signaling
T8933 25410-25418 NN denotes cascades
T8934 25418-25419 -COMMA- denotes ,
T8935 25420-25421 DT denotes a
T8936 25422-25429 JJ denotes similar
T8937 25430-25448 JJ denotes ubiquitin-mediated
T8938 25449-25459 NN denotes regulation
T8939 25460-25463 MD denotes may
T8940 25464-25468 VB denotes hold
T8941 25469-25473 JJ denotes true
T8942 25474-25477 IN denotes for
T8943 25478-25485 NN denotes SHARPIN
T8944 25486-25488 IN denotes in
T8945 25489-25493 NN denotes LPS-
T8946 25494-25497 CC denotes and
T8947 25498-25502 NN denotes poly
T8948 25503-25504 CD denotes I
T8949 25504-25505 -COLON- denotes :
T8950 25505-25514 JJ denotes C-induced
T8951 25515-25520 NN denotes NF-κB
T8952 25521-25531 NN denotes activation
T8953 25533-25535 IN denotes In
T8954 25536-25543 NN denotes summary
T8955 25543-25544 -COMMA- denotes ,
T8956 25545-25548 DT denotes the
T8957 25549-25556 JJ denotes present
T8958 25557-25562 NN denotes study
T8959 25563-25573 VB denotes identified
T8960 25574-25576 DT denotes an
T8961 25577-25590 JJ denotes indispensible
T8962 25591-25595 NN denotes role
T8963 25596-25598 IN denotes of
T8964 25599-25606 NN denotes SHARPIN
T8965 25607-25609 IN denotes in
T8966 25610-25613 DT denotes the
T8967 25614-25624 NN denotes production
T8968 25625-25627 IN denotes of
T8969 25628-25644 JJ denotes pro-inflammatory
T8970 25645-25654 NN denotes mediators
T8971 25655-25658 CC denotes and
T8972 25659-25670 JJ denotes TLR-induced
T8973 25671-25676 NN denotes NF-κB
T8974 25677-25686 NN denotes signaling
T8975 25688-25691 DT denotes The
T8976 25692-25700 JJ denotes impaired
T8977 25701-25716 JJ denotes Th1-stimulating
T8978 25717-25724 NN denotes ability
T8979 25725-25727 IN denotes of
T8980 25728-25745 JJ denotes Sharpin-deficient
T8981 25746-25748 NN denotes DC
T8982 25749-25752 MD denotes may
T8983 25753-25760 VB denotes account
T8984 25761-25764 IN denotes for
T8985 25765-25768 DT denotes the
T8986 25769-25781 JJ denotes Th2-dominant
T8987 25782-25794 JJ denotes inflammatory
T8988 25795-25804 NN denotes phenotype
T8989 25805-25807 IN denotes of
T8990 25808-25812 NN denotes cpdm
T8991 25813-25817 NN denotes mice
T8992 25819-25822 DT denotes The
T8993 25823-25830 NN denotes balance
T8994 25831-25838 IN denotes between
T8995 25839-25842 NN denotes Th1
T8996 25843-25846 CC denotes and
T8997 25847-25850 NN denotes Th2
T8998 25851-25866 NN denotes differentiation
T8999 25867-25869 VB denotes is
T9000 25870-25878 JJ denotes critical
T9001 25879-25882 IN denotes for
T9002 25883-25889 JJ denotes immune
T9003 25890-25901 NN denotes homeostasis
T9004 25903-25904 DT denotes A
T9005 25905-25911 JJ denotes better
T9006 25912-25925 NN denotes understanding
T9007 25926-25928 IN denotes of
T9008 25929-25932 WRB denotes how
T9009 25933-25937 JJ denotes such
T9010 25938-25945 NN denotes balance
T9011 25946-25948 VB denotes is
T9012 25949-25959 VB denotes maintained
T9013 25960-25964 MD denotes will
T9014 25965-25969 VB denotes help
T9015 25970-25976 VB denotes design
T9016 25977-25985 NN denotes cytokine
T9017 25986-25995 NN denotes treatment
T9018 25996-25999 IN denotes for
T9019 26000-26005 JJ denotes human
T9020 26006-26014 NN denotes diseases
T9021 26015-26019 IN denotes with
T9022 26020-26030 JJ denotes Th2-biased
T9023 26031-26039 NN denotes cytokine
T9024 26040-26049 NN denotes secretion
T9025 26050-26057 JJ denotes similar
T9026 26058-26060 TO denotes to
T9027 26061-26064 DT denotes the
T9028 26065-26070 NN denotes mouse
T9029 26071-26075 NN denotes cpdm
T9030 26075-26076 -COMMA- denotes ,
T9031 26077-26081 JJ denotes such
T9032 26082-26084 IN denotes as
T9033 26085-26094 NN denotes allergies
T9034 26095-26098 CC denotes and
T9035 26099-26116 JJ denotes hypereosinophilic
T9036 26117-26126 NN denotes syndromes
T9602 26152-26158 NNP denotes Ethics
T9603 26159-26168 NNP denotes Statement
T9604 26169-26172 DT denotes All
T9605 26173-26178 NN denotes mouse
T9606 26179-26183 NN denotes work
T9607 26184-26187 VB denotes was
T9608 26188-26195 VB denotes carried
T9609 26196-26199 RP denotes out
T9610 26200-26202 IN denotes in
T9611 26203-26209 JJ denotes strict
T9612 26210-26220 NN denotes accordance
T9613 26221-26225 IN denotes with
T9614 26226-26235 NN denotes protocols
T9615 26236-26244 VB denotes approved
T9616 26245-26247 IN denotes by
T9617 26248-26251 DT denotes the
T9618 26252-26265 NNP denotes Institutional
T9619 26266-26272 NNP denotes Animal
T9620 26273-26277 NNP denotes Care
T9621 26278-26281 CC denotes and
T9622 26282-26285 NNP denotes Use
T9623 26286-26296 NNP denotes Committees
T9786 26299-26303 NN denotes Mice
T9787 26304-26321 NN denotes Specific-pathogen
T9788 26322-26326 JJ denotes free
T9789 26327-26335 NN denotes colonies
T9790 26336-26338 IN denotes of
T9791 26339-26373 NN denotes C57BL/KaLawRij-Sharpincpdm/RijSunJ
T9792 26374-26375 -LRB- denotes (
T9793 26375-26377 NNP denotes JR
T9794 26377-26378 -SHARP- denotes #
T9795 26378-26382 CD denotes 7599
T9796 26382-26383 -RRB- denotes )
T9797 26384-26387 CC denotes and
T9798 26388-26390 JJ denotes WT
T9799 26391-26395 NN denotes mice
T9800 26396-26400 VB denotes were
T9801 26401-26409 VB denotes obtained
T9802 26410-26414 IN denotes from
T9803 26415-26418 DT denotes The
T9804 26419-26426 NNP denotes Jackson
T9805 26427-26437 NNP denotes Laboratory
T9806 26438-26439 -LRB- denotes (
T9807 26439-26442 NNP denotes Bar
T9808 26443-26449 NNP denotes Harbor
T9809 26449-26450 -COMMA- denotes ,
T9810 26451-26453 NN denotes ME
T9811 26453-26454 -RRB- denotes )
T9812 26455-26458 CC denotes and
T9813 26459-26463 VB denotes were
T9814 26464-26474 VB denotes maintained
T9815 26475-26477 IN denotes in
T9816 26478-26479 DT denotes a
T9817 26480-26487 NN denotes barrier
T9818 26488-26496 NN denotes facility
T9819 26498-26504 JJ denotes Normal
T9820 26505-26515 NN denotes littermate
T9821 26516-26524 NN denotes controls
T9822 26525-26529 VB denotes were
T9823 26530-26536 CC denotes either
T9824 26537-26540 SYM denotes +/+
T9825 26541-26543 CC denotes or
T9826 26544-26558 NNP denotes +/Sharpincpdm.
T9827 26559-26564 DT denotes These
T9828 26565-26572 NN denotes control
T9829 26573-26580 NN denotes animals
T9830 26581-26585 VB denotes were
T9831 26586-26600 RB denotes phenotypically
T9832 26601-26618 JJ denotes indistinguishable
T9833 26619-26622 CC denotes and
T9834 26623-26626 VB denotes are
T9835 26627-26635 VB denotes referred
T9836 26636-26638 TO denotes to
T9837 26639-26641 IN denotes as
T9838 26642-26644 NNP denotes WT
T9839 26646-26657 JJ denotes Sex-matched
T9840 26658-26660 NN denotes WT
T9841 26661-26664 CC denotes and
T9842 26665-26671 JJ denotes mutant
T9843 26672-26676 NN denotes mice
T9844 26677-26681 VB denotes were
T9845 26682-26686 VB denotes used
T9846 26687-26689 IN denotes at
T9847 26690-26694 CD denotes 6–10
T9848 26695-26700 NN denotes weeks
T9849 26701-26703 IN denotes of
T9850 26704-26707 NN denotes age
T9851 26709-26712 IN denotes For
T9852 26713-26717 DT denotes some
T9853 26718-26729 NN denotes experiments
T9854 26729-26730 -COMMA- denotes ,
T9855 26731-26735 NN denotes cpdm
T9856 26736-26740 NN denotes mice
T9857 26741-26745 VB denotes were
T9858 26746-26753 VB denotes crossed
T9859 26754-26758 IN denotes with
T9860 26759-26769 JJ denotes transgenic
T9861 26770-26774 NN denotes mice
T9862 26775-26779 IN denotes with
T9863 26780-26781 DT denotes a
T9864 26782-26791 JJ denotes bacterial
T9865 26792-26802 JJ denotes artificial
T9866 26803-26813 NN denotes chromosome
T9867 26814-26815 -LRB- denotes (
T9868 26815-26818 NN denotes BAC
T9869 26818-26819 -RRB- denotes )
T9870 26820-26830 VB denotes containing
T9871 26831-26834 DT denotes the
T9872 26835-26842 NN denotes Sharpin
T9873 26843-26847 NN denotes gene
T9874 26848-26849 -LRB- denotes (
T9875 26849-26858 NN denotes FVB/NJ-Tg
T9876 26858-26859 -LRB- denotes (
T9877 26859-26870 NN denotes RP24-173I23
T9878 26870-26871 -RRB- denotes )
T9879 26871-26879 NN denotes 1Sun/Sun
T9880 26879-26880 -COMMA- denotes ,
T9881 26881-26883 NNP denotes JR
T9882 26883-26884 -SHARP- denotes #
T9883 26884-26888 CD denotes 8279
T9884 26888-26889 -RRB- denotes )
T9885 26891-26896 DT denotes These
T9886 26897-26901 NN denotes mice
T9887 26902-26906 VB denotes were
T9888 26907-26918 VB denotes backcrossed
T9889 26919-26923 IN denotes onto
T9890 26924-26927 DT denotes the
T9891 26928-26962 NN denotes C57BL/KaLawRij-Sharpincpdm/RijSunJ
T9892 26963-26973 NN denotes background
T9893 26974-26977 CC denotes and
T9894 26978-26980 NN denotes N4
T9895 26981-26985 NN denotes mice
T9896 26986-26990 VB denotes were
T9897 26991-26995 VB denotes used
T9898 26996-26998 IN denotes in
T9899 26999-27002 DT denotes the
T9900 27003-27014 NN denotes experiments
T9901 27015-27023 VB denotes reported
T9902 27024-27028 RB denotes here
T9903 27030-27033 DT denotes All
T9904 27034-27039 NN denotes mouse
T9905 27040-27044 NN denotes work
T9906 27045-27048 VB denotes was
T9907 27049-27056 VB denotes carried
T9908 27057-27060 RP denotes out
T9909 27061-27063 IN denotes in
T9910 27064-27070 JJ denotes strict
T9911 27071-27081 NN denotes accordance
T9912 27082-27086 IN denotes with
T9913 27087-27090 DT denotes the
T9914 27091-27099 VB denotes approved
T9915 27100-27109 NN denotes protocols
T9916 27110-27112 IN denotes by
T9917 27113-27116 DT denotes the
T9918 27117-27130 NNP denotes Institutional
T9919 27131-27137 NNP denotes Animal
T9920 27138-27142 NNP denotes Care
T9921 27143-27146 CC denotes and
T9922 27147-27150 NNP denotes Use
T9923 27151-27160 NNP denotes Committee
T10135 27163-27173 NN denotes Constructs
T10136 27174-27177 CC denotes and
T10137 27178-27190 NN denotes transfection
T10138 27191-27194 DT denotes The
T10139 27195-27208 JJ denotes complementary
T10140 27209-27212 NN denotes DNA
T10141 27213-27214 -LRB- denotes (
T10142 27214-27218 NN denotes cDNA
T10143 27218-27219 -RRB- denotes )
T10144 27220-27222 IN denotes of
T10145 27223-27226 DT denotes the
T10146 27227-27232 NN denotes mouse
T10147 27233-27240 NN denotes Sharpin
T10148 27241-27245 NN denotes gene
T10149 27246-27249 VB denotes was
T10150 27250-27256 VB denotes cloned
T10151 27257-27260 CC denotes and
T10152 27261-27270 VB denotes amplified
T10153 27271-27275 IN denotes from
T10154 27276-27284 NN denotes RAW264.7
T10155 27285-27288 NN denotes RNA
T10156 27289-27297 NN denotes extracts
T10157 27299-27302 DT denotes The
T10158 27303-27309 NN denotes primer
T10159 27310-27319 NN denotes sequences
T10160 27320-27324 VB denotes were
T10161 27325-27332 RB denotes forward
T10162 27332-27333 -COMMA- denotes ,
T10163 27334-27339 NN denotes 5′-CC
T10164 27340-27343 NN denotes ATG
T10165 27344-27347 NN denotes GCG
T10166 27348-27351 NN denotes ATG
T10167 27352-27355 NN denotes TCG
T10168 27356-27359 NN denotes CCG
T10169 27360-27363 NN denotes CCC
T10170 27364-27367 NN denotes GCC
T10171 27368-27371 NN denotes GGC
T10172 27372-27375 NN denotes GGT
T10173 27375-27376 -COLON- denotes ;
T10174 27377-27384 NN denotes reverse
T10175 27384-27385 -COMMA- denotes ,
T10176 27386-27389 JJ denotes 5′-
T10177 27390-27393 NN denotes AAG
T10178 27394-27397 NN denotes CTT
T10179 27398-27401 NN denotes CTA
T10180 27402-27405 NNP denotes GGT
T10181 27406-27409 NNP denotes GGA
T10182 27410-27413 NNP denotes AGC
T10183 27414-27417 NNP denotes TGC
T10184 27418-27421 NNP denotes AGC
T10185 27422-27425 NN denotes AAG
T10186 27426-27428 NN denotes A.
T10187 27429-27432 DT denotes The
T10188 27433-27440 NNP denotes Sharpin
T10189 27441-27445 NN denotes cDNA
T10190 27446-27449 VB denotes was
T10191 27450-27456 VB denotes cloned
T10192 27457-27461 IN denotes into
T10193 27462-27472 NN denotes expression
T10194 27473-27479 NN denotes vector
T10195 27480-27491 NN denotes pFLAG-CMV-2
T10196 27493-27499 JJ denotes Murine
T10197 27500-27511 NN denotes fibroblasts
T10198 27512-27515 CC denotes and
T10199 27516-27527 NN denotes macrophages
T10200 27528-27532 VB denotes were
T10201 27533-27537 VB denotes were
T10202 27538-27542 VB denotes used
T10203 27543-27545 TO denotes to
T10204 27546-27553 VB denotes express
T10205 27554-27565 JJ denotes recombinant
T10206 27566-27573 NN denotes SHARPIN
T10207 27574-27581 NN denotes protein
T10208 27583-27588 NN denotes Cells
T10209 27589-27590 -LRB- denotes (
T10210 27590-27595 CD denotes 2×104
T10211 27595-27596 -RRB- denotes )
T10212 27597-27601 VB denotes were
T10213 27602-27608 VB denotes seeded
T10214 27609-27611 IN denotes in
T10215 27612-27619 JJ denotes 96-well
T10216 27620-27627 VB denotes treated
T10217 27628-27634 VB denotes plates
T10218 27635-27638 DT denotes the
T10219 27639-27642 NN denotes day
T10220 27643-27649 IN denotes before
T10221 27650-27662 NN denotes transfection
T10222 27664-27669 IN denotes After
T10223 27670-27679 JJ denotes overnight
T10224 27680-27690 NN denotes incubation
T10225 27690-27691 -COMMA- denotes ,
T10226 27692-27695 CD denotes 200
T10227 27696-27698 NN denotes ng
T10228 27699-27712 NN denotes pFLAG-SHARPIN
T10229 27713-27721 NN denotes plasmids
T10230 27722-27726 VB denotes were
T10231 27727-27738 VB denotes transfected
T10232 27739-27743 IN denotes with
T10233 27744-27747 CD denotes 0.5
T10234 27748-27750 NN denotes ul
T10235 27751-27764 NN denotes Lipofectamine
T10236 27765-27769 CD denotes 2000
T10237 27771-27773 CD denotes 24
T10238 27774-27779 NN denotes hours
T10239 27780-27785 RB denotes later
T10240 27785-27786 -COMMA- denotes ,
T10241 27787-27792 NN denotes cells
T10242 27793-27797 VB denotes were
T10243 27798-27807 VB denotes incubated
T10244 27808-27812 IN denotes with
T10245 27813-27818 JJ denotes fresh
T10246 27819-27826 NN denotes culture
T10247 27827-27833 NN denotes medium
T10248 27835-27840 IN denotes After
T10249 27841-27848 DT denotes another
T10250 27849-27851 CD denotes 24
T10251 27852-27857 NN denotes hours
T10252 27857-27858 -COMMA- denotes ,
T10253 27859-27864 NN denotes cells
T10254 27865-27869 VB denotes were
T10255 27870-27875 VB denotes lysed
T10256 27876-27878 TO denotes to
T10257 27879-27886 VB denotes confirm
T10258 27887-27890 DT denotes the
T10259 27891-27903 NN denotes FLAG-SHARPIN
T10260 27904-27914 NN denotes expression
T10261 27915-27917 IN denotes by
T10262 27918-27929 NN denotes immunoblots
T10263 27930-27934 IN denotes with
T10264 27935-27944 NN denotes anti-FLAG
T10265 27946-27951 NN denotes Cells
T10266 27952-27956 IN denotes with
T10267 27957-27959 DT denotes no
T10268 27960-27972 NN denotes transfection
T10269 27973-27976 CC denotes and
T10270 27977-27988 VB denotes transfected
T10271 27989-27993 IN denotes with
T10272 27994-27999 JJ denotes empty
T10273 28000-28006 NN denotes vector
T10274 28007-28018 NN denotes pFLAG-CMV-2
T10275 28019-28023 VB denotes were
T10276 28024-28028 VB denotes used
T10277 28029-28031 IN denotes as
T10278 28032-28040 JJ denotes negative
T10279 28041-28048 NN denotes control
T10280 28049-28051 IN denotes in
T10281 28052-28055 DT denotes all
T10282 28056-28068 NN denotes transfection
T10283 28069-28080 NN denotes experiments
T10381 28083-28093 NN denotes Generation
T10382 28094-28096 IN denotes of
T10383 28097-28101 NN denotes BMDC
T10384 28102-28106 NN denotes BMDC
T10385 28107-28111 VB denotes were
T10386 28112-28121 VB denotes developed
T10387 28122-28124 IN denotes as
T10388 28125-28135 RB denotes previously
T10389 28136-28144 VB denotes reported
T10390 28145-28146 -LRB- denotes [
T10391 28146-28148 CD denotes 54
T10392 28148-28149 -RRB- denotes ]
T10393 28149-28150 -COMMA- denotes ,
T10394 28151-28152 -LRB- denotes [
T10395 28152-28154 CD denotes 55
T10396 28154-28155 -RRB- denotes ]
T10397 28157-28162 NN denotes Cells
T10398 28163-28167 VB denotes were
T10399 28168-28177 VB denotes collected
T10400 28178-28183 IN denotes after
T10401 28184-28189 CD denotes 10–12
T10402 28190-28194 NN denotes days
T10403 28195-28197 IN denotes of
T10404 28198-28205 NN denotes culture
T10405 28207-28210 DT denotes The
T10406 28211-28215 NN denotes cell
T10407 28216-28221 NN denotes yield
T10408 28222-28225 VB denotes was
T10409 28226-28233 CD denotes 2–3×107
T10410 28234-28245 NN denotes cells/mouse
T10411 28246-28250 IN denotes with
T10412 28251-28256 CD denotes 80–95
T10413 28256-28257 NN denotes %
T10414 28258-28262 NN denotes BMDC
T10676 28265-28274 NN denotes Phenotype
T10677 28275-28277 IN denotes of
T10678 28278-28282 NN denotes BMDC
T10679 28283-28286 CC denotes and
T10680 28287-28294 JJ denotes splenic
T10681 28295-28297 NN denotes DC
T10682 28298-28305 NN denotes subsets
T10683 28306-28309 DT denotes The
T10684 28310-28319 NN denotes phenotype
T10685 28320-28322 IN denotes of
T10686 28323-28327 NN denotes BMDC
T10687 28328-28331 VB denotes was
T10688 28332-28342 VB denotes determined
T10689 28343-28349 IN denotes before
T10690 28350-28353 CC denotes and
T10691 28354-28359 IN denotes after
T10692 28360-28362 CD denotes 24
T10693 28363-28367 NN denotes hour
T10694 28368-28375 NN denotes culture
T10695 28376-28378 IN denotes in
T10696 28379-28382 DT denotes the
T10697 28383-28391 NN denotes presence
T10698 28392-28394 IN denotes of
T10699 28395-28398 CD denotes 100
T10700 28399-28404 NN denotes ng/mL
T10701 28405-28408 NN denotes LPS
T10702 28410-28413 DT denotes The
T10703 28414-28419 NN denotes cells
T10704 28420-28424 VB denotes were
T10705 28425-28434 VB denotes incubated
T10706 28435-28437 IN denotes in
T10707 28438-28441 NNP denotes PBS
T10708 28442-28446 IN denotes with
T10709 28447-28450 CD denotes 0.1
T10710 28450-28451 NN denotes %
T10711 28452-28456 NN denotes NaN3
T10712 28456-28457 -COMMA- denotes ,
T10713 28458-28459 CD denotes 1
T10714 28459-28460 NN denotes %
T10715 28461-28464 NN denotes BSA
T10716 28465-28468 CC denotes and
T10717 28469-28471 CD denotes 10
T10718 28471-28472 NN denotes %
T10719 28473-28479 JJ denotes normal
T10720 28480-28486 NN denotes rabbit
T10721 28487-28492 NN denotes serum
T10722 28493-28496 IN denotes for
T10723 28497-28499 CD denotes 20
T10724 28500-28507 NN denotes minutes
T10725 28508-28510 IN denotes on
T10726 28511-28514 NN denotes ice
T10727 28514-28515 -COMMA- denotes ,
T10728 28516-28522 VB denotes washed
T10729 28523-28526 CC denotes and
T10730 28527-28536 VB denotes incubated
T10731 28537-28540 IN denotes for
T10732 28541-28543 CD denotes 30
T10733 28544-28551 NN denotes minutes
T10734 28552-28554 IN denotes on
T10735 28555-28558 NN denotes ice
T10736 28559-28563 IN denotes with
T10737 28564-28568 NNP denotes Alex
T10738 28569-28582 JJ denotes Fluor-labeled
T10739 28583-28593 NN denotes anti-CD11c
T10740 28594-28595 -LRB- denotes (
T10741 28595-28603 NN denotes MCD11C20
T10742 28603-28604 -COMMA- denotes ,
T10743 28605-28611 NN denotes CALTAG
T10744 28611-28612 -RRB- denotes )
T10745 28613-28615 IN denotes in
T10746 28616-28627 NN denotes combination
T10747 28628-28632 IN denotes with
T10748 28633-28636 NN denotes PE-
T10749 28637-28646 NN denotes anti-CD40
T10750 28647-28648 -LRB- denotes (
T10751 28648-28652 CD denotes 3/23
T10752 28652-28653 -COMMA- denotes ,
T10753 28654-28656 NNP denotes BD
T10754 28657-28668 NNP denotes Biosciences
T10755 28668-28669 -RRB- denotes )
T10756 28669-28670 -COMMA- denotes ,
T10757 28671-28683 NN denotes PE-anti-CD80
T10758 28684-28685 -LRB- denotes (
T10759 28685-28692 NN denotes 16-10A1
T10760 28692-28693 -COMMA- denotes ,
T10761 28694-28705 NN denotes eBioscience
T10762 28705-28706 -RRB- denotes )
T10763 28706-28707 -COMMA- denotes ,
T10764 28708-28720 NN denotes PE-anti-CD86
T10765 28721-28722 -LRB- denotes (
T10766 28722-28727 NN denotes P03.1
T10767 28727-28728 -COMMA- denotes ,
T10768 28729-28740 NN denotes eBioscience
T10769 28740-28741 -RRB- denotes )
T10770 28741-28742 -COMMA- denotes ,
T10771 28743-28755 NN denotes PE-anti-CD14
T10772 28756-28757 -LRB- denotes (
T10773 28757-28762 NN denotes Sa2.8
T10774 28762-28763 -COMMA- denotes ,
T10775 28764-28775 NN denotes eBioscience
T10776 28775-28776 -RRB- denotes )
T10777 28777-28780 CC denotes and
T10778 28781-28793 VB denotes biotinylated
T10779 28794-28803 NN denotes anti-TLR4
T10780 28804-28805 -LRB- denotes (
T10781 28805-28814 NN denotes BioLegend
T10782 28814-28815 -RRB- denotes )
T10783 28817-28820 DT denotes The
T10784 28821-28826 NN denotes cells
T10785 28827-28836 VB denotes incubated
T10786 28837-28841 IN denotes with
T10787 28842-28854 VB denotes biotinylated
T10788 28855-28869 NN denotes anti-TLR4/MD-2
T10789 28870-28874 VB denotes were
T10790 28875-28881 VB denotes washed
T10791 28882-28887 RB denotes twice
T10792 28888-28891 CC denotes and
T10793 28892-28901 VB denotes incubated
T10794 28902-28905 IN denotes for
T10795 28906-28908 CD denotes 30
T10796 28909-28916 NN denotes minutes
T10797 28917-28919 IN denotes on
T10798 28920-28923 NN denotes ice
T10799 28924-28928 IN denotes with
T10800 28929-28938 NN denotes avidin-PE
T10801 28940-28942 TO denotes To
T10802 28943-28950 VB denotes isolate
T10803 28951-28958 JJ denotes splenic
T10804 28959-28961 NN denotes DC
T10805 28961-28962 -COMMA- denotes ,
T10806 28963-28970 NN denotes spleens
T10807 28971-28975 VB denotes were
T10808 28976-28987 NN denotes collagenase
T10809 28988-28996 VB denotes digested
T10810 28997-29000 CC denotes and
T10811 29001-29008 JJ denotes subject
T10812 29009-29011 TO denotes to
T10813 29012-29019 VB denotes Percoll
T10814 29020-29028 NN denotes gradient
T10815 29029-29043 NN denotes centrifugation
T10816 29045-29048 DT denotes The
T10817 29049-29054 NN denotes bands
T10818 29055-29057 IN denotes at
T10819 29058-29061 DT denotes the
T10820 29062-29067 CD denotes 35–55
T10821 29067-29068 NN denotes %
T10822 29069-29078 NN denotes interface
T10823 29079-29083 VB denotes were
T10824 29084-29093 VB denotes collected
T10825 29094-29096 TO denotes to
T10826 29097-29102 VB denotes stain
T10827 29103-29107 IN denotes with
T10828 29108-29121 NN denotes PE-anti-CD11c
T10829 29122-29123 -LRB- denotes (
T10830 29123-29126 NN denotes HL3
T10831 29126-29127 -COMMA- denotes ,
T10832 29128-29137 NNP denotes BioLegend
T10833 29137-29138 -RRB- denotes )
T10834 29138-29139 -COMMA- denotes ,
T10835 29140-29155 NN denotes APC-anti-PDCA-1
T10836 29156-29157 -LRB- denotes (
T10837 29157-29160 CD denotes 927
T10838 29160-29161 -COMMA- denotes ,
T10839 29162-29171 NNP denotes BioLegend
T10840 29171-29172 -RRB- denotes )
T10841 29173-29176 CC denotes and
T10842 29177-29191 NN denotes FITC-anti-CD8α
T10843 29192-29193 -LRB- denotes (
T10844 29193-29199 CD denotes 53–6.7
T10845 29199-29200 -COMMA- denotes ,
T10846 29201-29203 NNP denotes BD
T10847 29204-29214 NNP denotes BioScience
T10848 29214-29215 -RRB- denotes )
T10849 29217-29220 DT denotes The
T10850 29221-29226 NN denotes cells
T10851 29227-29231 VB denotes were
T10852 29232-29238 VB denotes washed
T10853 29239-29244 RB denotes twice
T10854 29244-29245 -COMMA- denotes ,
T10855 29246-29251 VB denotes fixed
T10856 29252-29254 IN denotes in
T10857 29255-29256 CD denotes 2
T10858 29256-29257 NN denotes %
T10859 29258-29274 NN denotes paraformaldehyde
T10860 29274-29275 -COMMA- denotes ,
T10861 29276-29279 CC denotes and
T10862 29280-29286 VB denotes stored
T10863 29287-29289 IN denotes at
T10864 29290-29293 NN denotes 4°C
T10865 29294-29299 IN denotes until
T10866 29300-29308 NN denotes analysis
T10867 29310-29314 NN denotes Flow
T10868 29315-29324 NN denotes cytometry
T10869 29325-29328 VB denotes was
T10870 29329-29338 VB denotes performed
T10871 29339-29341 IN denotes in
T10872 29342-29344 DT denotes an
T10873 29345-29350 NNP denotes Excel
T10874 29351-29352 -LRB- denotes (
T10875 29352-29359 NNP denotes Coulter
T10876 29359-29360 -RRB- denotes )
T10877 29361-29371 NN denotes instrument
T10878 29373-29377 NN denotes Dead
T10879 29378-29383 NN denotes cells
T10880 29384-29388 VB denotes were
T10881 29389-29396 VB denotes omitted
T10882 29397-29401 IN denotes from
T10883 29402-29405 DT denotes the
T10884 29406-29414 NN denotes analysis
T10885 29415-29417 IN denotes by
T10886 29418-29424 VB denotes gating
T10887 29425-29427 IN denotes on
T10888 29428-29435 JJ denotes forward
T10889 29436-29439 CC denotes and
T10890 29440-29443 CD denotes 90°
T10891 29444-29449 JJ denotes light
T10892 29450-29457 NN denotes scatter
T10893 29457-29458 -COMMA- denotes ,
T10894 29459-29462 CC denotes and
T10895 29463-29469 CD denotes 10,000
T10896 29470-29475 NN denotes cells
T10897 29476-29480 VB denotes were
T10898 29481-29489 VB denotes analyzed
T10899 29490-29492 IN denotes by
T10900 29493-29499 NNP denotes FlowJo
T10901 29500-29508 NN denotes software
T11111 29511-29517 NN denotes BMDC-T
T11112 29518-29522 NN denotes cell
T11113 29523-29525 FW denotes in
T11114 29526-29531 FW denotes vitro
T11115 29532-29543 NN denotes interaction
T11116 29544-29546 NN denotes WT
T11117 29547-29550 CC denotes and
T11118 29551-29555 NN denotes cpdm
T11119 29556-29560 NN denotes BMDC
T11120 29561-29562 -LRB- denotes (
T11121 29562-29567 CD denotes 5×104
T11122 29567-29568 -RRB- denotes )
T11123 29569-29573 VB denotes were
T11124 29574-29584 VB denotes stimulated
T11125 29585-29589 IN denotes with
T11126 29590-29596 NN denotes medium
T11127 29596-29597 -COMMA- denotes ,
T11128 29598-29599 CD denotes 1
T11129 29600-29605 NN denotes µg/mL
T11130 29606-29609 NN denotes LPS
T11131 29609-29610 -COMMA- denotes ,
T11132 29611-29613 CD denotes 25
T11133 29614-29619 NN denotes µg/mL
T11134 29620-29623 CC denotes and
T11135 29624-29625 CD denotes 5
T11136 29626-29631 NN denotes µg/mL
T11137 29632-29639 NN denotes Pam3CYS
T11138 29641-29643 CD denotes 24
T11139 29644-29649 NN denotes hours
T11140 29650-29655 RB denotes later
T11141 29655-29656 -COMMA- denotes ,
T11142 29657-29662 NN denotes cells
T11143 29663-29667 VB denotes were
T11144 29668-29677 VB denotes collected
T11145 29678-29681 CC denotes and
T11146 29682-29688 VB denotes washed
T11147 29689-29693 IN denotes with
T11148 29694-29697 NNP denotes PBS
T11149 29699-29709 JJ denotes Allogeneic
T11150 29710-29715 NN denotes naïve
T11151 29716-29720 JJ denotes CD4+
T11152 29721-29722 NN denotes T
T11153 29723-29728 NN denotes cells
T11154 29729-29733 VB denotes were
T11155 29734-29742 VB denotes isolated
T11156 29743-29747 IN denotes from
T11157 29748-29755 NN denotes spleens
T11158 29756-29758 IN denotes of
T11159 29759-29765 NN denotes BALB/c
T11160 29766-29770 NN denotes mice
T11161 29771-29773 IN denotes by
T11162 29774-29782 JJ denotes negative
T11163 29783-29792 NN denotes selection
T11164 29793-29796 NN denotes kit
T11165 29797-29798 -LRB- denotes (
T11166 29798-29808 NN denotes Invitrogen
T11167 29808-29809 -RRB- denotes )
T11168 29810-29813 CC denotes and
T11169 29814-29818 VB denotes were
T11170 29819-29823 RB denotes then
T11171 29824-29829 VB denotes added
T11172 29830-29832 IN denotes at
T11173 29833-29840 CD denotes 2.5×105
T11174 29841-29844 CC denotes and
T11175 29845-29856 VB denotes co-cultured
T11176 29857-29861 IN denotes with
T11177 29862-29871 VB denotes activated
T11178 29872-29876 NN denotes BMDC
T11179 29878-29883 IN denotes After
T11180 29884-29885 CD denotes 5
T11181 29886-29890 NN denotes days
T11182 29890-29891 -COMMA- denotes ,
T11183 29892-29903 NN denotes supernatant
T11184 29904-29907 VB denotes was
T11185 29908-29917 VB denotes collected
T11186 29918-29921 CC denotes and
T11187 29922-29925 DT denotes the
T11188 29926-29935 NN denotes secretion
T11189 29936-29938 IN denotes of
T11190 29939-29943 NN denotes IFNγ
T11191 29943-29944 -COMMA- denotes ,
T11192 29945-29948 NN denotes IL4
T11193 29948-29949 -COMMA- denotes ,
T11194 29950-29953 NN denotes IL2
T11195 29953-29954 -COMMA- denotes ,
T11196 29955-29958 CC denotes and
T11197 29959-29964 NN denotes IL17A
T11198 29965-29973 VB denotes measured
T11199 29974-29976 IN denotes by
T11200 29977-29982 NN denotes ELISA
T11201 29984-29992 JJ denotes Negative
T11202 29993-30001 NN denotes controls
T11203 30002-30005 VB denotes are
T11204 30006-30007 CD denotes 1
T11205 30007-30008 -RRB- denotes )
T11206 30009-30019 VB denotes stimulated
T11207 30020-30024 NN denotes BMDC
T11208 30025-30032 IN denotes without
T11209 30033-30043 NN denotes co-culture
T11210 30044-30048 IN denotes with
T11211 30049-30059 JJ denotes allogeneic
T11212 30060-30064 JJ denotes CD4+
T11213 30065-30066 NN denotes T
T11214 30067-30072 NN denotes cells
T11215 30072-30073 -COLON- denotes ;
T11216 30074-30075 LS denotes 2
T11217 30075-30076 -RRB- denotes )
T11218 30077-30087 JJ denotes allogeneic
T11219 30088-30092 JJ denotes CD4+
T11220 30093-30094 NN denotes T
T11221 30095-30100 NN denotes cells
T11222 30101-30108 IN denotes without
T11223 30109-30119 NN denotes co-culture
T11224 30120-30124 IN denotes with
T11225 30125-30135 VB denotes stimulated
T11226 30136-30140 NN denotes BMDC
T11227 30142-30146 DT denotes Both
T11228 30147-30155 JJ denotes negative
T11229 30156-30164 NN denotes controls
T11230 30165-30169 VB denotes show
T11231 30170-30172 DT denotes no
T11232 30173-30183 NN denotes production
T11233 30184-30186 IN denotes of
T11234 30187-30201 JJ denotes aforementioned
T11235 30202-30211 NN denotes cytokines
T11602 30214-30217 NN denotes RNA
T11603 30218-30228 NN denotes expression
T11604 30229-30231 IN denotes by
T11605 30232-30236 NN denotes BMDC
T11606 30237-30241 NN denotes BMDC
T11607 30242-30246 VB denotes were
T11608 30247-30255 VB denotes cultured
T11609 30256-30258 IN denotes at
T11610 30259-30262 CD denotes 106
T11611 30263-30271 NN denotes cells/mL
T11612 30272-30274 IN denotes in
T11613 30275-30277 CD denotes 10
T11614 30278-30280 NN denotes mL
T11615 30281-30283 IN denotes of
T11616 30284-30293 NN denotes RPMI-1640
T11617 30294-30302 JJ denotes complete
T11618 30303-30309 NN denotes medium
T11619 30310-30312 IN denotes in
T11620 30313-30316 DT denotes the
T11621 30317-30325 NN denotes presence
T11622 30326-30328 CC denotes or
T11623 30329-30336 NN denotes absence
T11624 30337-30339 IN denotes of
T11625 30340-30343 CD denotes 100
T11626 30344-30349 NN denotes ng/mL
T11627 30350-30353 NN denotes LPS
T11628 30354-30356 CC denotes or
T11629 30357-30359 CD denotes 25
T11630 30360-30365 NN denotes µg/mL
T11631 30366-30370 NN denotes poly
T11632 30371-30372 CD denotes I
T11633 30372-30373 -COLON- denotes :
T11634 30373-30375 NNP denotes C.
T11635 30376-30381 IN denotes After
T11636 30382-30383 CD denotes 1
T11637 30384-30387 CC denotes and
T11638 30388-30389 CD denotes 2
T11639 30390-30395 NN denotes hours
T11640 30395-30396 -COMMA- denotes ,
T11641 30397-30400 NN denotes RNA
T11642 30401-30404 VB denotes was
T11643 30405-30413 VB denotes isolated
T11644 30414-30418 IN denotes with
T11645 30419-30430 NN denotes TRI-reagent
T11646 30431-30432 -LRB- denotes (
T11647 30432-30437 NN denotes Sigma
T11648 30437-30438 -RRB- denotes )
T11649 30439-30448 VB denotes according
T11650 30449-30451 TO denotes to
T11651 30452-30455 DT denotes the
T11652 30456-30468 NN denotes manufacturer
T11653 30468-30470 POS denotes 's
T11654 30471-30483 NN denotes instructions
T11655 30485-30488 DT denotes The
T11656 30489-30499 NN denotes expression
T11657 30500-30502 IN denotes of
T11658 30503-30506 NN denotes Il6
T11659 30506-30507 -COMMA- denotes ,
T11660 30508-30515 NN denotes Il12p40
T11661 30515-30516 -COMMA- denotes ,
T11662 30517-30522 NN denotes Gmcsf
T11663 30522-30523 -COMMA- denotes ,
T11664 30524-30527 CC denotes and
T11665 30528-30535 NN denotes Sharpin
T11666 30536-30540 NN denotes mRNA
T11667 30541-30544 VB denotes was
T11668 30545-30555 VB denotes determined
T11669 30556-30558 IN denotes by
T11670 30559-30566 NN denotes qRT-PCR
T11671 30568-30575 NN denotes Primers
T11672 30576-30579 CC denotes and
T11673 30580-30586 NN denotes probes
T11674 30587-30591 VB denotes were
T11675 30592-30601 VB denotes purchased
T11676 30602-30606 IN denotes from
T11677 30607-30614 NNP denotes Applied
T11678 30615-30626 NNP denotes Biosystems.
T11679 30627-30634 NNP denotes Reverse
T11680 30635-30648 NN denotes transcription
T11681 30649-30652 VB denotes was
T11682 30653-30662 VB denotes performed
T11683 30663-30665 IN denotes at
T11684 30666-30670 NN denotes 42°C
T11685 30671-30674 IN denotes for
T11686 30675-30677 CD denotes 60
T11687 30678-30685 NN denotes minutes
T11688 30686-30690 IN denotes with
T11689 30691-30694 DT denotes the
T11690 30695-30700 JJ denotes final
T11691 30701-30713 NN denotes denaturation
T11692 30714-30718 NN denotes step
T11693 30719-30721 IN denotes at
T11694 30722-30726 NN denotes 90°C
T11695 30727-30730 IN denotes for
T11696 30731-30732 CD denotes 5
T11697 30733-30740 NN denotes minutes
T11698 30741-30743 IN denotes in
T11699 30744-30746 CD denotes 30
T11700 30747-30749 NN denotes µl
T11701 30750-30760 VB denotes containing
T11702 30761-30764 CD denotes 0.5
T11703 30765-30767 NN denotes µg
T11704 30768-30770 IN denotes of
T11705 30771-30776 JJ denotes total
T11706 30777-30781 NN denotes RNA.
T11707 30782-30787 NN denotes dNTPs
T11708 30787-30788 -COMMA- denotes ,
T11709 30789-30794 NN denotes oligo
T11710 30794-30795 -LRB- denotes (
T11711 30795-30797 NN denotes dT
T11712 30797-30798 -RRB- denotes )
T11713 30798-30800 CD denotes 15
T11714 30801-30807 NN denotes primer
T11715 30807-30808 -COMMA- denotes ,
T11716 30809-30820 JJ denotes recombinant
T11717 30821-30827 NNP denotes RNasin
T11718 30828-30840 NNP denotes Ribonuclease
T11719 30841-30850 NNP denotes Inhibitor
T11720 30850-30851 -COMMA- denotes ,
T11721 30852-30855 CC denotes and
T11722 30856-30861 NN denotes M-MLV
T11723 30862-30869 JJ denotes Reverse
T11724 30870-30883 NN denotes Transcriptase
T11725 30884-30885 -LRB- denotes (
T11726 30885-30888 DT denotes all
T11727 30889-30893 IN denotes from
T11728 30894-30901 NNP denotes Promega
T11729 30901-30902 -COMMA- denotes ,
T11730 30903-30910 NNP denotes Madison
T11731 30910-30911 -COMMA- denotes ,
T11732 30912-30914 NNP denotes WI
T11733 30914-30915 -RRB- denotes )
T11734 30916-30920 VB denotes were
T11735 30921-30925 VB denotes used
T11736 30926-30935 VB denotes according
T11737 30936-30938 TO denotes to
T11738 30939-30942 DT denotes the
T11739 30943-30955 NN denotes manufacturer
T11740 30955-30957 POS denotes 's
T11741 30958-30969 NN denotes instruction
T11742 30971-30978 JJ denotes Reverse
T11743 30979-30992 NN denotes transcription
T11744 30993-30996 VB denotes was
T11745 30997-31001 VB denotes done
T11746 31002-31004 IN denotes in
T11747 31005-31006 DT denotes a
T11748 31007-31014 NN denotes PTC-200
T11749 31015-31022 NNP denotes Peltier
T11750 31023-31030 NNP denotes Thermal
T11751 31031-31037 NNP denotes Cycler
T11752 31038-31039 -LRB- denotes (
T11753 31039-31041 NNP denotes MJ
T11754 31042-31050 NNP denotes Research
T11755 31050-31051 -COMMA- denotes ,
T11756 31052-31061 NNP denotes Watertown
T11757 31061-31062 -COMMA- denotes ,
T11758 31063-31065 JJ denotes MA
T11759 31065-31066 -RRB- denotes )
T11760 31066-31073 NN denotes . qRT-P
T11761 31073-31076 VB denotes CR
T11762 31076-31085 VB denotes was perfo
T11763 31085-31087 IN denotes rm
T11764 31087-31090 NNP denotes ed
T11765 31090-31095 NNP denotes in AB
T11766 31095-31099 CD denotes I Pr
T11767 31099-31107 NNP denotes ism 7700
T11768 31108-31117 NNP denotes Sequence
T11769 31117-31123 NNP denotes Detect
T11770 31123-31127 IN denotes ion
T11771 31127-31134 NNP denotes System
T11772 31134-31138 NNP denotes with
T11773 31139-31149 NN denotes TaqMan® Ge
T11774 31149-31155 NN denotes ne Exp
T11775 31155-31156 -LRB- denotes r
T11776 31156-31163 NNP denotes ession
T11777 31163-31173 NNP denotes Assays (Ap
T11778 31173-31174 -COMMA- denotes p
T11779 31174-31180 NNP denotes lied B
T11780 31180-31184 NNP denotes iosy
T11781 31184-31185 -COMMA- denotes s
T11782 31185-31187 NNP denotes te
T11783 31187-31188 -RRB- denotes m
T11784 31188-31191 IN denotes s,
T11785 31191-31196 NN denotes Foste
T11786 31196-31200 NN denotes r Ci
T11787 31200-31201 -COMMA- denotes t
T11788 31201-31204 NN denotes y,
T11789 31204-31205 -COMMA- denotes C
T11790 31205-31212 NN denotes A) for
T11791 31212-31213 -COMMA- denotes m
T11792 31213-31217 NNP denotes ouse
T11793 31218-31219 -COMMA- denotes A
T11794 31219-31224 NNP denotes ctb,
T11795 31224-31225 -COMMA- denotes I
T11796 31225-31228 CC denotes L6,
T11797 31229-31236 NNP denotes IL12p40
T11798 31236-31245 VB denotes , Ifnβ, G
T11799 31245-31247 TO denotes mc
T11800 31247-31250 DT denotes sf,
T11801 31251-31263 NN denotes and Sharpin
T11802 31263-31265 POS denotes ac
T11803 31265-31273 NN denotes cording
T11804 31305-31308 DT denotes The
T11805 31309-31319 JJ denotes endogenous
T11806 31320-31328 NN denotes standard
T11807 31329-31332 IN denotes for
T11808 31333-31346 NN denotes normalization
T11809 31347-31349 IN denotes of
T11810 31350-31353 DT denotes the
T11811 31354-31360 NN denotes target
T11812 31361-31365 NN denotes gene
T11813 31366-31369 VB denotes was
T11814 31370-31377 JJ denotes β-actin
T11815 31379-31387 JJ denotes Relative
T11816 31388-31392 NN denotes gene
T11817 31393-31403 NN denotes expression
T11818 31404-31407 VB denotes was
T11819 31408-31418 VB denotes calculated
T11820 31419-31424 VB denotes using
T11821 31425-31428 DT denotes the
T11822 31429-31435 NN denotes 2−ΔΔCt
T11823 31436-31442 NN denotes method
T11824 31443-31444 -LRB- denotes [
T11825 31444-31446 CD denotes 56
T11826 31446-31447 -RRB- denotes ]
T12001 31450-31452 FW denotes In
T12002 31453-31458 FW denotes vitro
T12003 31459-31467 NN denotes cytokine
T12004 31468-31477 NN denotes secretion
T12005 31478-31480 IN denotes by
T12006 31481-31485 NN denotes BMDC
T12007 31486-31489 DT denotes The
T12008 31490-31494 NN denotes BMDC
T12009 31495-31499 VB denotes were
T12010 31500-31508 VB denotes cultured
T12011 31509-31511 IN denotes in
T12012 31512-31522 JJ denotes triplicate
T12013 31523-31528 NN denotes wells
T12014 31529-31531 IN denotes of
T12015 31532-31539 JJ denotes 24-well
T12016 31540-31542 CC denotes or
T12017 31543-31550 JJ denotes 96-well
T12018 31551-31557 NN denotes plates
T12019 31558-31560 IN denotes at
T12020 31561-31564 CD denotes 106
T12021 31565-31567 CC denotes or
T12022 31568-31571 CD denotes 105
T12023 31572-31580 NN denotes cells/mL
T12024 31580-31581 -COMMA- denotes ,
T12025 31582-31594 RB denotes respectively
T12026 31594-31595 -COMMA- denotes ,
T12027 31596-31598 IN denotes in
T12028 31599-31608 NN denotes RPMI-1640
T12029 31609-31617 JJ denotes complete
T12030 31618-31624 NN denotes medium
T12031 31626-31629 DT denotes The
T12032 31630-31635 NN denotes cells
T12033 31636-31640 VB denotes were
T12034 31641-31647 VB denotes washed
T12035 31648-31651 CC denotes and
T12036 31652-31662 VB denotes stimulated
T12037 31663-31667 IN denotes with
T12038 31668-31671 CD denotes 100
T12039 31672-31677 NN denotes ng/mL
T12040 31678-31681 NN denotes LPS
T12041 31682-31684 CC denotes or
T12042 31685-31687 CD denotes 25
T12043 31688-31693 NN denotes µg/mL
T12044 31694-31698 NN denotes poly
T12045 31699-31700 CD denotes I
T12046 31700-31701 -COLON- denotes :
T12047 31701-31703 NNP denotes C.
T12048 31704-31709 IN denotes After
T12049 31710-31712 CD denotes 24
T12050 31713-31718 NN denotes hours
T12051 31718-31719 -COMMA- denotes ,
T12052 31720-31732 NN denotes supernatants
T12053 31733-31737 VB denotes were
T12054 31738-31747 VB denotes harvested
T12055 31748-31751 IN denotes for
T12056 31752-31757 NN denotes ELISA
T12057 31758-31766 NN denotes analysis
T12058 31768-31771 DT denotes The
T12059 31772-31780 NN denotes presence
T12060 31781-31783 IN denotes of
T12061 31784-31791 NN denotes nitrite
T12062 31792-31794 IN denotes in
T12063 31795-31798 DT denotes the
T12064 31799-31811 NN denotes supernatants
T12065 31812-31815 VB denotes was
T12066 31816-31826 VB denotes determined
T12067 31827-31832 VB denotes using
T12068 31833-31836 DT denotes the
T12069 31837-31843 NNP denotes Griess
T12070 31844-31851 NN denotes reagent
T12218 31854-31872 NN denotes Immunofluorescence
T12219 31873-31883 NN denotes Fibroblast
T12220 31884-31887 CC denotes and
T12221 31888-31898 NN denotes macrophage
T12222 31899-31904 NN denotes cells
T12223 31905-31909 VB denotes were
T12224 31910-31921 VB denotes transfected
T12225 31922-31926 IN denotes with
T12226 31927-31940 NN denotes pFLAG-SHARPIN
T12227 31942-31944 CD denotes 48
T12228 31945-31950 NN denotes hours
T12229 31951-31956 RB denotes later
T12230 31956-31957 -COMMA- denotes ,
T12231 31958-31963 NN denotes cells
T12232 31964-31968 VB denotes were
T12233 31969-31975 VB denotes washed
T12234 31976-31983 RB denotes briefly
T12235 31984-31988 IN denotes with
T12236 31989-31992 NNP denotes PBS
T12237 31992-31993 -COMMA- denotes ,
T12238 31994-31998 RB denotes then
T12239 31999-32004 VB denotes fixed
T12240 32005-32007 IN denotes in
T12241 32008-32012 JJ denotes cold
T12242 32013-32021 NN denotes methanol
T12243 32022-32024 IN denotes at
T12244 32025-32030 NN denotes −20°C
T12245 32031-32034 IN denotes for
T12246 32035-32037 CD denotes 10
T12247 32038-32045 NN denotes minutes
T12248 32046-32049 CC denotes and
T12249 32050-32054 JJ denotes cold
T12250 32055-32062 NN denotes acetone
T12251 32063-32065 IN denotes at
T12252 32066-32071 NN denotes -20°C
T12253 32072-32075 IN denotes for
T12254 32076-32077 CD denotes 1
T12255 32078-32084 NN denotes minute
T12256 32086-32094 NN denotes Incubate
T12257 32095-32100 NN denotes cells
T12258 32101-32105 IN denotes with
T12259 32106-32111 NN denotes PBS+1
T12260 32111-32112 NN denotes %
T12261 32113-32116 NN denotes BSA
T12262 32117-32120 IN denotes for
T12263 32121-32123 CD denotes 15
T12264 32124-32131 NN denotes minutes
T12265 32132-32134 TO denotes to
T12266 32135-32140 VB denotes block
T12267 32141-32153 JJ denotes non-specific
T12268 32154-32161 NN denotes binding
T12269 32163-32168 VB denotes Fixed
T12270 32169-32174 NN denotes cells
T12271 32175-32179 VB denotes were
T12272 32180-32184 RB denotes then
T12273 32185-32194 VB denotes incubated
T12274 32195-32199 IN denotes with
T12275 32200-32209 JJ denotes anti-FLAG
T12276 32210-32211 -LRB- denotes (
T12277 32211-32216 CD denotes 1∶100
T12278 32216-32217 -RRB- denotes )
T12279 32218-32220 IN denotes as
T12280 32221-32224 DT denotes the
T12281 32225-32232 JJ denotes primary
T12282 32233-32241 NN denotes antibody
T12283 32242-32244 IN denotes at
T12284 32245-32249 NN denotes room
T12285 32250-32261 NN denotes temperature
T12286 32262-32265 IN denotes for
T12287 32266-32267 CD denotes 1
T12288 32268-32272 NN denotes hour
T12289 32272-32273 -COMMA- denotes ,
T12290 32274-32282 VB denotes followed
T12291 32283-32285 IN denotes by
T12292 32286-32291 CD denotes three
T12293 32292-32300 JJ denotes 5-minute
T12294 32301-32307 NN denotes washes
T12295 32309-32314 NN denotes Cells
T12296 32315-32319 VB denotes were
T12297 32320-32327 RB denotes further
T12298 32328-32337 VB denotes incubated
T12299 32338-32342 IN denotes with
T12300 32343-32347 NN denotes goat
T12301 32348-32359 JJ denotes anti-rabbit
T12302 32360-32368 NN denotes IgG-FITC
T12303 32369-32370 -LRB- denotes (
T12304 32370-32375 CD denotes 1∶100
T12305 32375-32376 -RRB- denotes )
T12306 32377-32379 IN denotes as
T12307 32380-32383 DT denotes the
T12308 32384-32393 JJ denotes secondary
T12309 32394-32402 NN denotes antibody
T12310 32403-32405 IN denotes at
T12311 32406-32410 NN denotes room
T12312 32411-32422 NN denotes temperature
T12313 32423-32426 IN denotes for
T12314 32427-32429 CD denotes 30
T12315 32430-32437 NN denotes minutes
T12316 32437-32438 -COMMA- denotes ,
T12317 32439-32447 VB denotes followed
T12318 32448-32450 IN denotes by
T12319 32451-32456 CD denotes three
T12320 32457-32465 JJ denotes 5-minute
T12321 32466-32472 NN denotes washes
T12322 32474-32479 NN denotes Cells
T12323 32480-32484 VB denotes were
T12324 32485-32489 RB denotes then
T12325 32490-32498 VB denotes examined
T12326 32499-32504 VB denotes using
T12327 32505-32512 JJ denotes inverse
T12328 32513-32525 NN denotes fluorescence
T12329 32526-32536 NN denotes microscope
T12503 32539-32550 NN denotes Immunoblots
T12504 32551-32556 IN denotes After
T12505 32557-32563 VB denotes adding
T12506 32564-32575 VB denotes stimulating
T12507 32576-32583 NN denotes ligands
T12508 32583-32584 -COMMA- denotes ,
T12509 32585-32588 CD denotes 100
T12510 32589-32594 NN denotes ng/mL
T12511 32595-32598 NN denotes LPS
T12512 32599-32601 CC denotes or
T12513 32602-32604 CD denotes 25
T12514 32605-32610 NN denotes µg/mL
T12515 32611-32615 NN denotes poly
T12516 32616-32617 NN denotes I
T12517 32617-32618 -COLON- denotes :
T12518 32618-32619 NN denotes C
T12519 32619-32620 -COMMA- denotes ,
T12520 32621-32625 NN denotes BMDC
T12521 32626-32630 VB denotes were
T12522 32631-32640 VB denotes collected
T12523 32641-32644 CC denotes and
T12524 32645-32650 VB denotes lysed
T12525 32651-32653 IN denotes at
T12526 32654-32656 CD denotes 0-
T12527 32656-32657 -COMMA- denotes ,
T12528 32658-32661 CD denotes 15-
T12529 32661-32662 -COMMA- denotes ,
T12530 32663-32666 CD denotes 30-
T12531 32666-32667 -COMMA- denotes ,
T12532 32668-32671 CC denotes and
T12533 32672-32681 JJ denotes 60-minute
T12534 32682-32686 NN denotes time
T12535 32687-32693 NN denotes points
T12536 32695-32706 NN denotes Immunoblots
T12537 32707-32711 VB denotes were
T12538 32712-32721 VB denotes performed
T12539 32722-32726 IN denotes with
T12540 32727-32737 NN denotes antibodies
T12541 32738-32739 -LRB- denotes (
T12542 32739-32743 NNP denotes Cell
T12543 32744-32753 NNP denotes Signaling
T12544 32754-32764 NNP denotes Technology
T12545 32764-32765 -RRB- denotes )
T12546 32766-32773 IN denotes against
T12547 32774-32782 NN denotes p-IKK1/2
T12548 32782-32783 -LRB- denotes (
T12549 32783-32784 -SHARP- denotes #
T12550 32784-32788 CD denotes 2697
T12551 32788-32789 -RRB- denotes )
T12552 32789-32790 -COMMA- denotes ,
T12553 32791-32797 NN denotes p-IκBα
T12554 32798-32799 -LRB- denotes (
T12555 32799-32800 -SHARP- denotes #
T12556 32800-32804 CD denotes 9246
T12557 32804-32805 -RRB- denotes )
T12558 32805-32806 -COMMA- denotes ,
T12559 32807-32811 NN denotes IκBα
T12560 32812-32813 -LRB- denotes (
T12561 32813-32814 -SHARP- denotes #
T12562 32814-32818 CD denotes 4814
T12563 32818-32819 -RRB- denotes )
T12564 32819-32820 -COMMA- denotes ,
T12565 32821-32827 NN denotes p-TBK1
T12566 32827-32828 -LRB- denotes (
T12567 32828-32829 -SHARP- denotes #
T12568 32829-32833 CD denotes 5483
T12569 32833-32834 -RRB- denotes )
T12570 32834-32835 -COMMA- denotes ,
T12571 32836-32841 NN denotes p-p38
T12572 32842-32843 -LRB- denotes (
T12573 32843-32844 -SHARP- denotes #
T12574 32844-32848 CD denotes 9216
T12575 32848-32849 -RRB- denotes )
T12576 32849-32850 -COMMA- denotes ,
T12577 32851-32854 NN denotes p38
T12578 32855-32856 -LRB- denotes (
T12579 32856-32857 -SHARP- denotes #
T12580 32857-32861 CD denotes 9212
T12581 32861-32862 -RRB- denotes )
T12582 32862-32863 -COMMA- denotes ,
T12583 32864-32872 NN denotes p-ERK1/2
T12584 32873-32874 -LRB- denotes (
T12585 32874-32875 -SHARP- denotes #
T12586 32875-32879 CD denotes 4376
T12587 32879-32880 -RRB- denotes )
T12588 32880-32881 -COMMA- denotes ,
T12589 32882-32885 CC denotes and
T12590 32886-32892 NN denotes ERK1/2
T12591 32893-32894 -LRB- denotes (
T12592 32894-32895 -SHARP- denotes #
T12593 32895-32899 CD denotes 4695
T12594 32899-32900 -RRB- denotes )
T12595 32902-32912 NN denotes Beta-actin
T12596 32913-32914 -LRB- denotes (
T12597 32914-32922 NN denotes sc-47778
T12598 32922-32923 -COMMA- denotes ,
T12599 32924-32929 NNP denotes Santa
T12600 32930-32934 NNP denotes Cruz
T12601 32935-32948 NNP denotes Biotechnology
T12602 32948-32949 -RRB- denotes )
T12603 32950-32953 VB denotes was
T12604 32954-32958 VB denotes used
T12605 32959-32961 IN denotes as
T12606 32962-32969 VB denotes loading
T12607 32970-32977 NN denotes control
T12709 32980-32991 JJ denotes Statistical
T12710 32992-33000 NN denotes analysis
T12711 33001-33005 NN denotes Data
T12712 33006-33009 VB denotes are
T12713 33010-33019 VB denotes expressed
T12714 33020-33022 IN denotes as
T12715 33023-33027 JJ denotes mean
T12716 33028-33029 NN denotes ±
T12717 33030-33032 NN denotes SD
T12718 33034-33037 DT denotes The
T12719 33038-33049 JJ denotes statistical
T12720 33050-33062 NN denotes significance
T12721 33063-33065 IN denotes of
T12722 33066-33077 NN denotes differences
T12723 33078-33080 IN denotes of
T12724 33081-33086 NN denotes means
T12725 33087-33094 IN denotes between
T12726 33095-33107 JJ denotes experimental
T12727 33108-33114 NN denotes groups
T12728 33115-33118 VB denotes was
T12729 33119-33129 VB denotes determined
T12730 33130-33132 IN denotes by
T12731 33133-33141 NN denotes Students
T12732 33141-33142 POS denotes '
T12733 33143-33149 NN denotes t-test
R10000 T12036 T12037 arg1Of stimulated,with
R10001 T12038 T12039 arg1Of 100,ng/mL
R10002 T12040 T12038 arg1Of LPS,100
R10003 T12040 T12041 arg1Of LPS,or
R10004 T12041 T12037 arg2Of or,with
R10005 T12041 T12046 arg1Of or,:
R10006 T12044 T12041 arg2Of poly,or
R10007 T12044 T12042 arg1Of poly,25
R10008 T12044 T12043 arg1Of poly,µg/mL
R10009 T12044 T12045 arg1Of poly,I
R10010 T12047 T12046 arg2Of C.,:
R10011 T12050 T12048 arg2Of hours,After
R10012 T12050 T12049 arg1Of hours,24
R10013 T12052 T12053 arg1Of supernatants,were
R10014 T12052 T12054 arg2Of supernatants,harvested
R10015 T12054 T12051 arg2Of harvested,","
R10016 T12054 T12053 arg2Of harvested,were
R10017 T12054 T12055 arg1Of harvested,for
R10018 T12057 T12055 arg2Of analysis,for
R10019 T12057 T12056 arg1Of analysis,ELISA
R10020 T12059 T12058 arg1Of presence,The
R10021 T12059 T12060 arg1Of presence,of
R10022 T12059 T12062 arg1Of presence,in
R10023 T12059 T12065 arg1Of presence,was
R10024 T12059 T12066 arg2Of presence,determined
R10025 T12061 T12060 arg2Of nitrite,of
R10026 T12064 T12062 arg2Of supernatants,in
R10027 T12064 T12063 arg1Of supernatants,the
R10028 T12066 T12065 arg2Of determined,was
R10029 T12067 T12066 arg3Of using,determined
R10030 T12070 T12067 arg2Of reagent,using
R10031 T12070 T12068 arg1Of reagent,the
R10032 T12070 T12069 arg1Of reagent,Griess
R10161 T12219 T12220 arg1Of Fibroblast,and
R10162 T12221 T12220 arg2Of macrophage,and
R10163 T12222 T12219 arg1Of cells,Fibroblast
R10164 T12222 T12221 arg1Of cells,macrophage
R10165 T12222 T12223 arg1Of cells,were
R10166 T12222 T12224 arg2Of cells,transfected
R10167 T12224 T12223 arg2Of transfected,were
R10168 T12224 T12225 arg1Of transfected,with
R10169 T12226 T12225 arg2Of pFLAG-SHARPIN,with
R10170 T12228 T12227 arg1Of hours,48
R10171 T12229 T12228 arg1Of later,hours
R10172 T12231 T12232 arg1Of cells,were
R10173 T12231 T12233 arg2Of cells,washed
R10174 T12233 T12229 arg1Of washed,later
R10175 T12233 T12230 arg1Of washed,","
R10176 T12233 T12232 arg2Of washed,were
R10177 T12233 T12234 arg1Of washed,briefly
R10178 T12233 T12235 arg1Of washed,with
R10179 T12236 T12235 arg2Of PBS,with
R10180 T12236 T12237 arg1Of PBS,","
R10181 T12236 T12239 arg2Of PBS,fixed
R10182 T12239 T12238 arg1Of fixed,then
R10183 T12239 T12240 arg1Of fixed,in
R10184 T12242 T12240 arg2Of methanol,in
R10185 T12242 T12241 arg1Of methanol,cold
R10186 T12242 T12243 arg1Of methanol,at
R10187 T12244 T12243 arg2Of −20°C,at
R10188 T12244 T12245 arg1Of −20°C,for
R10189 T12244 T12251 arg1Of −20°C,at
R10190 T12247 T12246 arg1Of minutes,10
R10191 T12247 T12248 arg1Of minutes,and
R10192 T12248 T12245 arg2Of and,for
R10193 T12250 T12248 arg2Of acetone,and
R10194 T12250 T12249 arg1Of acetone,cold
R10195 T12252 T12251 arg2Of -20°C,at
R10196 T12252 T12253 arg1Of -20°C,for
R10197 T12255 T12253 arg2Of minute,for
R10198 T12255 T12254 arg1Of minute,1
R10199 T12257 T12256 arg1Of cells,Incubate
R10200 T12257 T12258 arg1Of cells,with
R10201 T12257 T12262 arg1Of cells,for
R10202 T12261 T12258 arg2Of BSA,with
R10203 T12261 T12259 arg1Of BSA,PBS+1
R10204 T12261 T12260 arg1Of BSA,%
R10205 T12264 T12262 arg2Of minutes,for
R10206 T12264 T12263 arg1Of minutes,15
R10207 T12264 T12266 arg1Of minutes,block
R10208 T12266 T12262 arg3Of block,for
R10209 T12266 T12265 arg1Of block,to
R10210 T12268 T12266 arg2Of binding,block
R10211 T12268 T12267 arg1Of binding,non-specific
R10212 T12270 T12269 arg2Of cells,Fixed
R10213 T12270 T12271 arg1Of cells,were
R10214 T12270 T12273 arg2Of cells,incubated
R10215 T12273 T12271 arg2Of incubated,were
R10216 T12273 T12272 arg1Of incubated,then
R10217 T12273 T12274 arg1Of incubated,with
R10218 T12273 T12279 arg1Of incubated,as
R10219 T12273 T12289 arg1Of incubated,","
R10220 T12273 T12290 modOf incubated,followed
R10221 T12275 T12274 arg2Of anti-FLAG,with
R10222 T12275 T12276 arg1Of anti-FLAG,(
R10223 T12277 T12276 arg2Of 1∶100,(
R10224 T12278 T12276 arg3Of ),(
R10225 T12282 T12279 arg2Of antibody,as
R10226 T12282 T12280 arg1Of antibody,the
R10227 T12282 T12281 arg1Of antibody,primary
R10228 T12282 T12283 arg1Of antibody,at
R10229 T12285 T12283 arg2Of temperature,at
R10230 T12285 T12284 arg1Of temperature,room
R10231 T12285 T12286 arg1Of temperature,for
R10232 T12288 T12286 arg2Of hour,for
R10233 T12288 T12287 arg1Of hour,1
R10234 T12294 T12290 arg1Of washes,followed
R10235 T12294 T12291 arg2Of washes,by
R10236 T12294 T12292 arg1Of washes,three
R10237 T12294 T12293 arg1Of washes,5-minute
R10238 T12295 T12296 arg1Of Cells,were
R10239 T12295 T12298 arg2Of Cells,incubated
R10240 T12298 T12296 arg2Of incubated,were
R10241 T12298 T12297 arg1Of incubated,further
R10242 T12298 T12299 arg1Of incubated,with
R10243 T12298 T12306 arg1Of incubated,as
R10244 T12298 T12316 arg1Of incubated,","
R10245 T12298 T12317 modOf incubated,followed
R10246 T12302 T12299 arg2Of IgG-FITC,with
R10247 T12302 T12300 arg1Of IgG-FITC,goat
R10248 T12302 T12301 arg1Of IgG-FITC,anti-rabbit
R10249 T12302 T12303 arg1Of IgG-FITC,(
R10250 T12304 T12303 arg2Of 1∶100,(
R10251 T12305 T12303 arg3Of ),(
R10252 T12309 T12306 arg2Of antibody,as
R10253 T12309 T12307 arg1Of antibody,the
R10254 T12309 T12308 arg1Of antibody,secondary
R10255 T12309 T12310 arg1Of antibody,at
R10256 T12312 T12310 arg2Of temperature,at
R10257 T12312 T12311 arg1Of temperature,room
R10258 T12312 T12313 arg1Of temperature,for
R10259 T12315 T12313 arg2Of minutes,for
R10260 T12315 T12314 arg1Of minutes,30
R10261 T12321 T12317 arg1Of washes,followed
R10262 T12321 T12318 arg2Of washes,by
R10263 T12321 T12319 arg1Of washes,three
R10264 T12321 T12320 arg1Of washes,5-minute
R10265 T12322 T12323 arg1Of Cells,were
R10266 T12322 T12325 arg2Of Cells,examined
R10267 T12325 T12323 arg2Of examined,were
R10268 T12325 T12324 arg1Of examined,then
R10269 T12325 T12326 modOf examined,using
R10270 T12329 T12326 arg2Of microscope,using
R10271 T12329 T12327 arg1Of microscope,inverse
R10272 T12329 T12328 arg1Of microscope,fluorescence
R10390 T12505 T12504 arg2Of adding,After
R10391 T12505 T12517 arg1Of adding,:
R10392 T12505 T12518 arg1Of adding,C
R10393 T12507 T12506 arg1Of ligands,stimulating
R10394 T12507 T12508 arg1Of ligands,","
R10395 T12508 T12512 arg1Of ",",or
R10396 T12509 T12510 arg1Of 100,ng/mL
R10397 T12511 T12509 arg1Of LPS,100
R10398 T12511 T12508 arg2Of LPS,","
R10399 T12512 T12505 arg2Of or,adding
R10400 T12516 T12512 arg2Of I,or
R10401 T12516 T12513 arg1Of I,25
R10402 T12516 T12514 arg1Of I,µg/mL
R10403 T12516 T12515 arg1Of I,poly
R10404 T12520 T12505 arg1Of BMDC,adding
R10405 T12520 T12521 arg1Of BMDC,were
R10406 T12520 T12522 arg2Of BMDC,collected
R10407 T12520 T12524 arg2Of BMDC,lysed
R10408 T12522 T12523 arg1Of collected,and
R10409 T12523 T12504 arg1Of and,After
R10410 T12523 T12519 arg1Of and,","
R10411 T12523 T12521 arg2Of and,were
R10412 T12523 T12525 arg1Of and,at
R10413 T12524 T12523 arg2Of lysed,and
R10414 T12526 T12527 arg1Of 0-,","
R10415 T12528 T12527 arg2Of 15-,","
R10416 T12530 T12532 arg1Of 30-,and
R10417 T12532 T12531 arg1Of and,","
R10418 T12533 T12532 arg2Of 60-minute,and
R10419 T12535 T12525 arg2Of points,at
R10420 T12535 T12526 arg1Of points,0-
R10421 T12535 T12528 arg1Of points,15-
R10422 T12535 T12529 arg1Of points,","
R10423 T12535 T12530 arg1Of points,30-
R10424 T12535 T12533 arg1Of points,60-minute
R10425 T12535 T12534 arg1Of points,time
R10426 T12536 T12537 arg1Of Immunoblots,were
R10427 T12536 T12538 arg2Of Immunoblots,performed
R10428 T12538 T12537 arg2Of performed,were
R10429 T12538 T12539 arg1Of performed,with
R10430 T12540 T12539 arg2Of antibodies,with
R10431 T12540 T12541 arg1Of antibodies,(
R10432 T12540 T12546 arg1Of antibodies,against
R10433 T12544 T12541 arg2Of Technology,(
R10434 T12544 T12542 arg1Of Technology,Cell
R10435 T12544 T12543 arg1Of Technology,Signaling
R10436 T12545 T12541 arg3Of ),(
R10437 T12547 T12548 arg1Of p-IKK1/2,(
R10438 T12547 T12552 arg1Of p-IKK1/2,","
R10439 T12550 T12548 arg2Of 2697,(
R10440 T12550 T12549 arg1Of 2697,#
R10441 T12551 T12548 arg3Of ),(
R10442 T12552 T12558 arg1Of ",",","
R10443 T12553 T12552 arg2Of p-IκBα,","
R10444 T12553 T12554 arg1Of p-IκBα,(
R10445 T12556 T12554 arg2Of 9246,(
R10446 T12556 T12555 arg1Of 9246,#
R10447 T12557 T12554 arg3Of ),(
R10448 T12558 T12546 arg2Of ",",against
R10449 T12559 T12560 arg1Of IκBα,(
R10450 T12559 T12564 arg1Of IκBα,","
R10451 T12562 T12560 arg2Of 4814,(
R10452 T12562 T12561 arg1Of 4814,#
R10453 T12563 T12560 arg3Of ),(
R10454 T12564 T12570 arg1Of ",",","
R10455 T12565 T12564 arg2Of p-TBK1,","
R10456 T12565 T12566 arg1Of p-TBK1,(
R10457 T12568 T12566 arg2Of 5483,(
R10458 T12568 T12567 arg1Of 5483,#
R10459 T12569 T12566 arg3Of ),(
R10460 T12570 T12576 arg1Of ",",","
R10461 T12571 T12570 arg2Of p-p38,","
R10462 T12571 T12572 arg1Of p-p38,(
R10463 T12574 T12572 arg2Of 9216,(
R10464 T12574 T12573 arg1Of 9216,#
R10465 T12575 T12572 arg3Of ),(
R10466 T12576 T12558 arg2Of ",",","
R10467 T12577 T12578 arg1Of p38,(
R10468 T12577 T12582 arg1Of p38,","
R10469 T12580 T12578 arg2Of 9212,(
R10470 T12580 T12579 arg1Of 9212,#
R10471 T12581 T12578 arg3Of ),(
R10472 T12582 T12589 arg1Of ",",and
R10473 T12583 T12582 arg2Of p-ERK1/2,","
R10474 T12583 T12584 arg1Of p-ERK1/2,(
R10475 T12586 T12584 arg2Of 4376,(
R10476 T12586 T12585 arg1Of 4376,#
R10477 T12587 T12584 arg3Of ),(
R10478 T12589 T12576 arg2Of and,","
R10479 T12589 T12588 arg1Of and,","
R10480 T12590 T12589 arg2Of ERK1/2,and
R10481 T12590 T12591 arg1Of ERK1/2,(
R10482 T12593 T12591 arg2Of 4695,(
R10483 T12593 T12592 arg1Of 4695,#
R10484 T12594 T12591 arg3Of ),(
R10485 T12595 T12596 arg1Of Beta-actin,(
R10486 T12595 T12603 arg1Of Beta-actin,was
R10487 T12595 T12604 arg2Of Beta-actin,used
R10488 T12597 T12596 arg2Of sc-47778,(
R10489 T12597 T12598 arg1Of sc-47778,","
R10490 T12601 T12598 arg2Of Biotechnology,","
R10491 T12601 T12599 arg1Of Biotechnology,Santa
R10492 T12601 T12600 arg1Of Biotechnology,Cruz
R10493 T12602 T12596 arg3Of ),(
R10494 T12604 T12603 arg2Of used,was
R10495 T12604 T12605 arg1Of used,as
R10496 T12606 T12605 arg2Of loading,as
R10497 T12607 T12606 arg2Of control,loading
R10525 T12710 T12709 arg1Of analysis,Statistical
R10526 T12711 T12712 arg1Of Data,are
R10527 T12711 T12713 arg2Of Data,expressed
R10528 T12713 T12712 arg2Of expressed,are
R10529 T12713 T12714 arg1Of expressed,as
R10530 T12717 T12714 arg2Of SD,as
R10531 T12717 T12715 arg1Of SD,mean
R10532 T12717 T12716 arg1Of SD,±
R10533 T12720 T12718 arg1Of significance,The
R10534 T12720 T12719 arg1Of significance,statistical
R10535 T12720 T12721 arg1Of significance,of
R10536 T12720 T12728 arg1Of significance,was
R10537 T12720 T12729 arg2Of significance,determined
R10538 T12722 T12721 arg2Of differences,of
R10539 T12722 T12723 arg1Of differences,of
R10540 T12722 T12725 arg1Of differences,between
R10541 T12724 T12723 arg2Of means,of
R10542 T12727 T12725 arg2Of groups,between
R10543 T12727 T12726 arg1Of groups,experimental
R10544 T12729 T12728 arg2Of determined,was
R10545 T12731 T12732 arg2Of Students,'
R10546 T12733 T12729 arg1Of t-test,determined
R10547 T12733 T12730 arg2Of t-test,by
R10548 T12733 T12732 arg1Of t-test,'
R10778 T12992 T12991 arg1Of vivo,In
R10779 T12992 T12993 arg1Of vivo,and
R10780 T12995 T12993 arg2Of vitro,and
R10781 T12995 T12994 arg1Of vitro,in
R10782 T12996 T12992 arg1Of features,vivo
R10783 T12996 T12995 arg1Of features,vitro
R10784 T12996 T12997 arg1Of features,of
R10785 T12998 T12997 arg2Of SHARPIN,of
R10786 T13000 T12999 arg2Of A,(
R10787 T13001 T12999 arg3Of ),(
R10788 T13002 T13003 arg1Of COILS,and
R10789 T13004 T13003 arg2Of MotifScan,and
R10790 T13005 T12999 arg1Of programs,(
R10791 T13005 T13002 arg1Of programs,COILS
R10792 T13005 T13004 arg1Of programs,MotifScan
R10793 T13005 T13006 arg1Of programs,were
R10794 T13005 T13007 arg2Of programs,used
R10795 T13007 T13006 arg2Of used,were
R10796 T13009 T13007 arg3Of predict,used
R10797 T13009 T13008 arg1Of predict,to
R10798 T13011 T13009 arg2Of presence,predict
R10799 T13011 T13010 arg1Of presence,the
R10800 T13011 T13012 arg1Of presence,of
R10801 T13015 T13014 arg2Of coiled-coil,(
R10802 T13016 T13014 arg3Of ),(
R10803 T13017 T13013 arg1Of domain,CC
R10804 T13017 T13014 arg1Of domain,(
R10805 T13017 T13018 arg1Of domain,","
R10806 T13018 T13024 arg1Of ",",and
R10807 T13021 T13020 arg2Of ubiquitin-like,(
R10808 T13022 T13020 arg3Of ),(
R10809 T13023 T13018 arg2Of domain,","
R10810 T13023 T13019 arg1Of domain,UBL
R10811 T13023 T13020 arg1Of domain,(
R10812 T13024 T13012 arg2Of and,of
R10813 T13024 T13033 arg1Of and,which
R10814 T13024 T13034 arg1Of and,form
R10815 T13025 T13026 arg1Of ZFRBP,(
R10816 T13029 T13026 arg2Of protein,(
R10817 T13029 T13027 arg1Of protein,zinc-finger
R10818 T13029 T13028 arg1Of protein,Ran-Binding
R10819 T13029 T13030 arg1Of protein,2
R10820 T13031 T13026 arg3Of ),(
R10821 T13032 T13024 arg2Of domain,and
R10822 T13032 T13025 arg1Of domain,ZFRBP
R10823 T13037 T13034 arg2Of patterns,form
R10824 T13037 T13035 arg1Of patterns,similar
R10825 T13037 T13036 arg1Of patterns,motif
R10826 T13037 T13038 arg1Of patterns,in
R10827 T13037 T13042 arg1Of patterns,of
R10828 T13041 T13038 arg2Of protein,in
R10829 T13041 T13039 arg1Of protein,the
R10830 T13041 T13040 arg1Of protein,SHARPIN
R10831 T13043 T13044 arg1Of human,","
R10832 T13045 T13046 arg1Of mouse,and
R10833 T13046 T13044 arg2Of and,","
R10834 T13048 T13046 arg2Of origins.,and
R10835 T13048 T13047 arg1Of origins.,rat
R10836 T13048 T13049 arg1Of origins.,(
R10837 T13050 T13049 arg2Of B,(
R10838 T13051 T13049 arg3Of ),(
R10839 T13054 T13042 arg2Of females,of
R10840 T13054 T13043 arg1Of females,human
R10841 T13054 T13045 arg1Of females,mouse
R10842 T13054 T13048 arg1Of females,origins.
R10843 T13054 T13052 arg1Of females,Eight
R10844 T13054 T13053 arg1Of females,week-old
R10845 T13054 T13055 arg1Of females,of
R10846 T13056 T13057 arg1Of WT,and
R10847 T13058 T13057 arg2Of cpdm,and
R10848 T13059 T13055 arg2Of mice,of
R10849 T13059 T13056 arg1Of mice,WT
R10850 T13059 T13058 arg1Of mice,cpdm
R10851 T13062 T13060 arg1Of mice,The
R10852 T13062 T13061 arg1Of mice,mutant
R10853 T13062 T13066 arg1Of mice,develop
R10854 T13066 T13063 arg1Of develop,(
R10855 T13066 T13064 arg1Of develop,above
R10856 T13066 T13065 arg1Of develop,)
R10857 T13069 T13066 arg2Of inflammation,develop
R10858 T13069 T13067 arg1Of inflammation,progressive
R10859 T13069 T13068 arg1Of inflammation,skin
R10860 T13069 T13070 arg1Of inflammation,starting
R10861 T13070 T13071 arg1Of starting,at
R10862 T13073 T13072 arg1Of four,about
R10863 T13074 T13073 arg1Of weeks.,four
R10864 T13074 T13075 arg1Of weeks.,(
R10865 T13076 T13075 arg2Of C,(
R10866 T13077 T13075 arg3Of ),(
R10867 T13078 T13074 arg1Of Extramedullary,weeks.
R10868 T13080 T13071 arg2Of causes,at
R10869 T13080 T13078 arg1Of causes,Extramedullary
R10870 T13080 T13079 arg1Of causes,hematopoiesis
R10871 T13080 T13093 modOf causes,were
R10872 T13082 T13081 arg1Of enlargement,marked
R10873 T13082 T13083 arg1Of enlargement,of
R10874 T13082 T13093 arg1Of enlargement,were
R10875 T13082 T13094 arg2Of enlargement,incubated
R10876 T13085 T13083 arg2Of spleen,of
R10877 T13085 T13084 arg1Of spleen,the
R10878 T13085 T13086 arg1Of spleen,of
R10879 T13088 T13087 arg1Of mice.,cpdm
R10880 T13088 T13089 arg1Of mice.,(
R10881 T13090 T13089 arg2Of D,(
R10882 T13091 T13089 arg3Of ),(
R10883 T13092 T13086 arg2Of BMDC,of
R10884 T13092 T13088 arg1Of BMDC,mice.
R10885 T13094 T13093 arg2Of incubated,were
R10886 T13094 T13095 arg1Of incubated,in
R10887 T13097 T13098 arg1Of absence,or
R10888 T13098 T13095 arg2Of or,in
R10889 T13098 T13096 arg1Of or,the
R10890 T13098 T13100 arg1Of or,of
R10891 T13099 T13098 arg2Of presence,or
R10892 T13101 T13102 arg1Of 100,ng/ml
R10893 T13103 T13100 arg2Of LPS,of
R10894 T13103 T13101 arg1Of LPS,100
R10895 T13103 T13104 arg1Of LPS,for
R10896 T13106 T13104 arg2Of hours,for
R10897 T13106 T13105 arg1Of hours,4
R10898 T13109 T13107 arg1Of level,The
R10899 T13109 T13108 arg1Of level,mRNA
R10900 T13109 T13110 arg1Of level,of
R10901 T13109 T13112 arg1Of level,was
R10902 T13109 T13113 arg2Of level,measured
R10903 T13109 T13117 arg1Of level,presented
R10904 T13111 T13110 arg2Of Sharpin,of
R10905 T13113 T13112 arg2Of measured,was
R10906 T13113 T13114 arg1Of measured,by
R10907 T13113 T13116 arg1Of measured,and
R10908 T13115 T13114 arg2Of qRT-PCR,by
R10909 T13117 T13116 arg2Of presented,and
R10910 T13117 T13119 arg1Of presented,to
R10911 T13119 T13118 arg1Of to,relative
R10912 T13122 T13119 arg2Of expression,to
R10913 T13122 T13120 arg1Of expression,the
R10914 T13122 T13121 arg1Of expression,mRNA
R10915 T13122 T13123 arg1Of expression,in
R10916 T13126 T13123 arg2Of BMDC,in
R10917 T13126 T13124 arg1Of BMDC,non-stimulated
R10918 T13126 T13125 arg1Of BMDC,WT
R10919 T13127 T13128 arg1Of Bars,represent
R10920 T13128 T13140 arg1Of represent,;
R10921 T13132 T13128 arg2Of s.d.,represent
R10922 T13132 T13129 arg1Of s.d.,the
R10923 T13132 T13130 arg1Of s.d.,mean
R10924 T13132 T13131 arg1Of s.d.,±
R10925 T13132 T13133 arg1Of s.d.,of
R10926 T13139 T13133 arg2Of 0.05,of
R10927 T13139 T13134 arg1Of 0.05,3
R10928 T13139 T13135 arg1Of 0.05,mice.
R10929 T13139 T13136 arg1Of 0.05,*
R10930 T13139 T13137 arg1Of 0.05,P
R10931 T13139 T13138 arg1Of 0.05,<
R10932 T13144 T13143 arg1Of 0.001.,<
R10933 T13146 T13145 arg2Of E,(
R10934 T13147 T13145 arg3Of ),(
R10935 T13148 T13141 arg1Of Fibroblast,**
R10936 T13148 T13142 arg1Of Fibroblast,P
R10937 T13148 T13144 arg1Of Fibroblast,0.001.
R10938 T13148 T13145 arg1Of Fibroblast,(
R10939 T13148 T13149 arg1Of Fibroblast,(
R10940 T13148 T13152 arg1Of Fibroblast,and
R10941 T13150 T13149 arg2Of NIH3T3,(
R10942 T13151 T13149 arg3Of ),(
R10943 T13152 T13154 arg1Of and,(
R10944 T13153 T13152 arg2Of macrophages,and
R10945 T13155 T13154 arg2Of RAW264.7,(
R10946 T13156 T13154 arg3Of ),(
R10947 T13157 T13148 arg1Of cells,Fibroblast
R10948 T13157 T13153 arg1Of cells,macrophages
R10949 T13157 T13158 arg1Of cells,were
R10950 T13157 T13159 arg2Of cells,transfected
R10951 T13159 T13140 arg2Of transfected,;
R10952 T13159 T13158 arg2Of transfected,were
R10953 T13159 T13160 arg1Of transfected,with
R10954 T13164 T13160 arg2Of pFLAG-SHARPIN,with
R10955 T13164 T13161 arg1Of pFLAG-SHARPIN,the
R10956 T13164 T13162 arg1Of pFLAG-SHARPIN,expression
R10957 T13164 T13163 arg1Of pFLAG-SHARPIN,plasmid
R10958 T13167 T13165 arg2Of hours,After
R10959 T13167 T13166 arg1Of hours,48
R10960 T13169 T13170 arg1Of cells,were
R10961 T13169 T13171 arg2Of cells,fixed
R10962 T13169 T13173 arg2Of cells,probed
R10963 T13171 T13172 arg1Of fixed,and
R10964 T13172 T13165 arg1Of and,After
R10965 T13172 T13168 arg1Of and,","
R10966 T13172 T13170 arg2Of and,were
R10967 T13173 T13172 arg2Of probed,and
R10968 T13173 T13174 arg1Of probed,with
R10969 T13175 T13176 arg1Of anti-FLAG,and
R10970 T13177 T13176 arg2Of FITC-conjugated,and
R10971 T13179 T13174 arg2Of antibody,with
R10972 T13179 T13175 arg1Of antibody,anti-FLAG
R10973 T13179 T13177 arg1Of antibody,FITC-conjugated
R10974 T13179 T13178 arg1Of antibody,secondary
R10975 T13180 T13181 arg1Of Nuclei,were
R10976 T13180 T13182 arg2Of Nuclei,stained
R10977 T13182 T13181 arg2Of stained,were
R10978 T13182 T13183 arg1Of stained,with
R10979 T13184 T13183 arg2Of DAPI,with
R10980 T13189 T13185 arg2Of lines,In
R10981 T13189 T13186 arg1Of lines,both
R10982 T13189 T13187 arg2Of lines,transfected
R10983 T13189 T13188 arg1Of lines,cell
R10984 T13191 T13192 arg1Of FLAG-SHARPIN,was
R10985 T13191 T13193 arg2Of FLAG-SHARPIN,found
R10986 T13191 T13195 arg1Of FLAG-SHARPIN,be
R10987 T13191 T13196 arg1Of FLAG-SHARPIN,cytoplasm-localized
R10988 T13193 T13185 arg1Of found,In
R10989 T13193 T13190 arg1Of found,","
R10990 T13193 T13192 arg2Of found,was
R10991 T13195 T13193 arg3Of be,found
R10992 T13195 T13194 arg1Of be,to
R10993 T13196 T13195 arg2Of cytoplasm-localized,be
R11269 T13537 T13538 arg1Of Effect,of
R11270 T13537 T13541 arg1Of Effect,on
R11271 T13540 T13538 arg2Of mutation,of
R11272 T13540 T13539 arg1Of mutation,Sharpin
R11273 T13543 T13542 arg1Of subpopulations,DC
R11274 T13543 T13544 arg1Of subpopulations,and
R11275 T13544 T13541 arg2Of and,on
R11276 T13545 T13544 arg2Of maturation,and
R11277 T13547 T13546 arg2Of A,(
R11278 T13548 T13546 arg3Of ),(
R11279 T13549 T13546 arg1Of Spleens,(
R11280 T13549 T13550 arg1Of Spleens,from
R11281 T13549 T13555 arg1Of Spleens,were
R11282 T13549 T13556 arg2Of Spleens,isolated
R11283 T13549 T13558 arg1Of Spleens,subject
R11284 T13551 T13552 arg1Of WT,and
R11285 T13553 T13552 arg2Of cpdm,and
R11286 T13554 T13550 arg2Of mice,from
R11287 T13554 T13551 arg1Of mice,WT
R11288 T13554 T13553 arg1Of mice,cpdm
R11289 T13556 T13557 arg1Of isolated,and
R11290 T13557 T13555 arg2Of and,were
R11291 T13558 T13557 arg2Of subject,and
R11292 T13558 T13559 arg1Of subject,to
R11293 T13560 T13561 arg1Of collagenase,and
R11294 T13561 T13559 arg2Of and,to
R11295 T13563 T13561 arg2Of digestion,and
R11296 T13563 T13562 arg1Of digestion,DNase
R11297 T13567 T13564 arg1Of homogenates,The
R11298 T13567 T13565 arg2Of homogenates,obtained
R11299 T13567 T13566 arg1Of homogenates,splenic
R11300 T13567 T13568 arg1Of homogenates,were
R11301 T13567 T13569 arg2Of homogenates,centrifuged
R11302 T13569 T13568 arg2Of centrifuged,were
R11303 T13569 T13570 arg1Of centrifuged,over
R11304 T13573 T13570 arg2Of gradient,over
R11305 T13573 T13571 arg1Of gradient,a
R11306 T13573 T13572 arg1Of gradient,Percoll
R11307 T13573 T13574 arg1Of gradient,(
R11308 T13573 T13582 arg1Of gradient,for
R11309 T13576 T13575 arg1Of %,35
R11310 T13576 T13577 arg1Of %,and
R11311 T13577 T13579 arg1Of and,%
R11312 T13578 T13577 arg2Of 55,and
R11313 T13580 T13574 arg2Of density,(
R11314 T13580 T13576 arg1Of density,%
R11315 T13580 T13578 arg1Of density,55
R11316 T13581 T13574 arg3Of ),(
R11317 T13584 T13582 arg2Of minutes,for
R11318 T13584 T13583 arg1Of minutes,15
R11319 T13586 T13585 arg1Of bands,The
R11320 T13586 T13587 arg1Of bands,at
R11321 T13586 T13597 arg1Of bands,were
R11322 T13586 T13598 arg2Of bands,pooled
R11323 T13586 T13600 arg2Of bands,washed
R11324 T13586 T13602 arg2Of bands,stained
R11325 T13589 T13590 arg1Of 35,%
R11326 T13591 T13588 arg1Of -medium,the
R11327 T13591 T13589 arg1Of -medium,35
R11328 T13591 T13592 arg1Of -medium,and
R11329 T13592 T13587 arg2Of and,at
R11330 T13594 T13595 arg1Of 35–55,%
R11331 T13596 T13592 arg2Of interface,and
R11332 T13596 T13593 arg1Of interface,the
R11333 T13596 T13594 arg1Of interface,35–55
R11334 T13598 T13599 arg1Of pooled,","
R11335 T13599 T13601 arg1Of ",",and
R11336 T13600 T13599 arg2Of washed,","
R11337 T13601 T13597 arg2Of and,were
R11338 T13602 T13601 arg2Of stained,and
R11339 T13602 T13603 arg1Of stained,with
R11340 T13605 T13603 arg2Of combination,with
R11341 T13605 T13604 arg1Of combination,a
R11342 T13605 T13606 arg1Of combination,of
R11343 T13605 T13609 modOf combination,to
R11344 T13605 T13628 modOf combination,were
R11345 T13608 T13606 arg2Of antibodies,of
R11346 T13608 T13607 arg1Of antibodies,various
R11347 T13610 T13609 arg1Of stain,to
R11348 T13613 T13610 arg2Of subsets,stain
R11349 T13613 T13611 arg1Of subsets,different
R11350 T13613 T13612 arg1Of subsets,DC
R11351 T13613 T13614 arg1Of subsets,","
R11352 T13616 T13617 arg1Of CD11c+CD8α+,","
R11353 T13617 T13619 arg1Of ",",and
R11354 T13618 T13617 arg2Of CD11c+CD8α−,","
R11355 T13619 T13614 arg2Of and,","
R11356 T13619 T13615 arg1Of and,conventional
R11357 T13621 T13619 arg2Of DC,and
R11358 T13621 T13620 arg1Of DC,plasmacytoid
R11359 T13623 T13622 arg2Of CD11c−PDCA-1+,(
R11360 T13624 T13622 arg3Of ),(
R11361 T13627 T13622 arg1Of panels,(
R11362 T13627 T13625 arg1Of panels,.The
R11363 T13627 T13626 arg1Of panels,top
R11364 T13627 T13628 arg1Of panels,were
R11365 T13627 T13629 arg2Of panels,gated
R11366 T13629 T13628 arg2Of gated,were
R11367 T13629 T13630 arg1Of gated,on
R11368 T13629 T13633 modOf gated,to
R11369 T13632 T13630 arg2Of cells,on
R11370 T13632 T13631 arg1Of cells,FSChiSSClo
R11371 T13634 T13633 arg1Of show,to
R11372 T13636 T13634 arg2Of populations,show
R11373 T13636 T13635 arg1Of populations,separate
R11374 T13636 T13637 arg1Of populations,of
R11375 T13638 T13639 arg1Of CD11c+PDCA-1−,and
R11376 T13640 T13639 arg2Of CD11c−PDCA-1+,and
R11377 T13641 T13637 arg2Of cells,of
R11378 T13641 T13638 arg1Of cells,CD11c+PDCA-1−
R11379 T13641 T13640 arg1Of cells,CD11c−PDCA-1+
R11380 T13643 T13642 arg1Of gating,Further
R11381 T13643 T13644 arg1Of gating,on
R11382 T13643 T13648 arg1Of gating,gave
R11383 T13647 T13644 arg2Of subpopulation,on
R11384 T13647 T13645 arg1Of subpopulation,the
R11385 T13647 T13646 arg1Of subpopulation,CD11c+PDCA-1−
R11386 T13651 T13648 arg2Of panel,gave
R11387 T13651 T13649 arg1Of panel,the
R11388 T13651 T13650 arg1Of panel,bottom
R11389 T13652 T13648 arg3Of that,gave
R11390 T13652 T13653 arg1Of that,showed
R11391 T13656 T13653 arg2Of pools,showed
R11392 T13656 T13654 arg1Of pools,two
R11393 T13656 T13655 arg1Of pools,distinct
R11394 T13656 T13657 arg1Of pools,of
R11395 T13661 T13657 arg2Of cells,of
R11396 T13661 T13658 arg1Of cells,CD11c+CD8α+
R11397 T13661 T13659 arg1Of cells,and
R11398 T13661 T13660 arg1Of cells,CD11c+CD8α−
R11399 T13662 T13663 arg1Of Percentages,were
R11400 T13662 T13664 arg2Of Percentages,calculated
R11401 T13662 T13671 arg1Of Percentages,were
R11402 T13662 T13673 arg2Of Percentages,shown
R11403 T13664 T13663 arg2Of calculated,were
R11404 T13664 T13665 arg1Of calculated,based
R11405 T13664 T13670 arg1Of calculated,and
R11406 T13666 T13665 arg2Of on,based
R11407 T13669 T13666 arg2Of population,on
R11408 T13669 T13667 arg1Of population,the
R11409 T13669 T13668 arg1Of population,parental
R11410 T13673 T13670 arg2Of shown,and
R11411 T13673 T13671 arg2Of shown,were
R11412 T13673 T13672 arg1Of shown,additionally
R11413 T13673 T13674 arg1Of shown,as
R11414 T13673 T13680 arg1Of shown,(
R11415 T13673 T13708 arg1Of shown,5
R11416 T13676 T13674 arg2Of graphs,as
R11417 T13676 T13675 arg1Of graphs,bar
R11418 T13676 T13677 arg1Of graphs,(
R11419 T13678 T13677 arg2Of n = 2,(
R11420 T13679 T13677 arg3Of ),(
R11421 T13681 T13680 arg2Of B,(
R11422 T13682 T13680 arg3Of ),(
R11423 T13684 T13683 arg2Of (,.
R11424 T13685 T13683 arg3Of C,.
R11425 T13686 T13683 arg1Of ) ,.
R11426 T13686 T13687 arg1Of ) ,WT
R11427 T13687 T13673 arg3Of WT ,shown
R11428 T13687 T13694 modOf WT ,cell
R11429 T13687 T13707 arg1Of WT ,2
R11430 T13689 T13687 arg2Of cpdm,WT
R11431 T13689 T13688 arg1Of cpdm,and
R11432 T13689 T13690 arg1Of cpdm,B
R11433 T13691 T13690 arg2Of MDC (,B
R11434 T13692 T13690 arg3Of 5,B
R11435 T13693 T13694 arg1Of ×105),cell
R11436 T13693 T13695 arg2Of ×105),s were sti
R11437 T13695 T13694 arg2Of s were sti,cell
R11438 T13695 T13696 arg1Of s were sti,mula
R11439 T13697 T13698 arg1Of ted wi,t
R11440 T13698 T13702 arg1Of t,00
R11441 T13699 T13700 arg1Of h m,edium
R11442 T13701 T13698 arg2Of ", 1",t
R11443 T13701 T13699 arg1Of ", 1",h m
R11444 T13702 T13696 arg2Of 00,mula
R11445 T13706 T13702 arg2Of r,00
R11446 T13706 T13703 arg1Of r,ng
R11447 T13706 T13704 arg1Of r,/ml L
R11448 T13706 T13705 arg1Of r,PS o
R11449 T13708 T13709 arg1Of 5,µg/
R11450 T13711 T13709 arg2Of poly ,µg/
R11451 T13711 T13710 arg1Of poly ,ml
R11452 T13713 T13712 arg1Of cells,The
R11453 T13713 T13714 arg1Of cells,were
R11454 T13713 T13715 arg2Of cells,labeled
R11455 T13713 T13726 arg2Of cells,subjected
R11456 T13713 T13728 arg1Of cells,flow
R11457 T13715 T13716 arg1Of labeled,with
R11458 T13715 T13725 arg1Of labeled,and
R11459 T13718 T13717 arg1Of anti-CD40,PE-labeled
R11460 T13718 T13719 arg1Of anti-CD40,","
R11461 T13719 T13722 arg1Of ",",and
R11462 T13720 T13719 arg2Of anti-CD80,","
R11463 T13722 T13716 arg2Of and,with
R11464 T13722 T13721 arg1Of and,","
R11465 T13723 T13722 arg2Of anti-CD86,and
R11466 T13725 T13714 arg2Of and,were
R11467 T13725 T13724 arg1Of and,","
R11468 T13726 T13725 arg2Of subjected,and
R11469 T13728 T13726 arg3Of flow,subjected
R11470 T13728 T13727 arg1Of flow,to
R11471 T13730 T13728 arg2Of analysis,flow
R11472 T13730 T13729 arg1Of analysis,cytometry
R11473 T13732 T13731 arg1Of populations,The
R11474 T13732 T13733 arg2Of populations,shown
R11475 T13732 T13736 arg1Of populations,were
R11476 T13732 T13737 arg2Of populations,gated
R11477 T13733 T13734 arg1Of shown,in
R11478 T13735 T13734 arg2Of histograms,in
R11479 T13737 T13736 arg2Of gated,were
R11480 T13737 T13738 arg1Of gated,on
R11481 T13740 T13738 arg2Of cells,on
R11482 T13740 T13739 arg1Of cells,CD11c+
R11483 T13742 T13741 arg1Of cells,Unstained
R11484 T13742 T13743 arg1Of cells,served
R11485 T13743 T13744 arg1Of served,as
R11486 T13746 T13744 arg2Of controls,as
R11487 T13746 T13745 arg1Of controls,negative
R11488 T13747 T13748 arg1Of Results,are
R11489 T13747 T13749 arg1Of Results,representative
R11490 T13749 T13748 arg2Of representative,are
R11491 T13749 T13750 arg1Of representative,of
R11492 T13753 T13750 arg2Of experiments,of
R11493 T13753 T13751 arg1Of experiments,two
R11494 T13753 T13752 arg1Of experiments,independent
R11703 T14019 T14018 arg1Of production,Defective
R11704 T14019 T14020 arg1Of production,of
R11705 T14022 T14020 arg2Of mediators,of
R11706 T14022 T14021 arg1Of mediators,pro-inflammatory
R11707 T14022 T14023 arg1Of mediators,from
R11708 T14026 T14023 arg2Of BMDC,from
R11709 T14026 T14024 arg2Of BMDC,stimulated
R11710 T14026 T14025 arg1Of BMDC,cpdm
R11711 T14028 T14027 arg2Of A–D,(
R11712 T14029 T14027 arg3Of ),(
R11713 T14031 T14032 arg1Of WT,and
R11714 T14033 T14032 arg2Of cpdm,and
R11715 T14034 T14027 arg1Of BMDC,(
R11716 T14034 T14030 arg1Of BMDC,Cultured
R11717 T14034 T14031 arg1Of BMDC,WT
R11718 T14034 T14033 arg1Of BMDC,cpdm
R11719 T14034 T14035 arg1Of BMDC,(
R11720 T14034 T14044 arg1Of BMDC,were
R11721 T14034 T14045 arg2Of BMDC,washed
R11722 T14034 T14047 arg2Of BMDC,stimulated
R11723 T14037 T14035 arg2Of cells,(
R11724 T14037 T14036 arg1Of cells,1×105
R11725 T14037 T14038 arg1Of cells,in
R11726 T14042 T14038 arg2Of medium,in
R11727 T14042 T14039 arg1Of medium,0.1
R11728 T14042 T14040 arg1Of medium,ml
R11729 T14042 T14041 arg1Of medium,complete
R11730 T14043 T14035 arg3Of ),(
R11731 T14045 T14046 arg1Of washed,and
R11732 T14046 T14044 arg2Of and,were
R11733 T14046 T14048 arg1Of and,with
R11734 T14047 T14046 arg2Of stimulated,and
R11735 T14049 T14050 arg1Of medium,","
R11736 T14050 T14054 arg1Of ",",or
R11737 T14051 T14052 arg1Of 100,ng/ml
R11738 T14053 T14050 arg2Of LPS,","
R11739 T14053 T14051 arg1Of LPS,100
R11740 T14054 T14048 arg2Of or,with
R11741 T14058 T14057 arg1Of I,poly
R11742 T14058 T14059 arg1Of I,:
R11743 T14060 T14054 arg2Of C,or
R11744 T14060 T14055 arg1Of C,25
R11745 T14060 T14056 arg1Of C,µg/ml
R11746 T14060 T14058 arg1Of C,I
R11747 T14060 T14061 arg1Of C,for
R11748 T14063 T14061 arg2Of hours,for
R11749 T14063 T14062 arg1Of hours,24
R11750 T14064 T14065 arg1Of Supernatants,were
R11751 T14064 T14066 arg2Of Supernatants,collected
R11752 T14066 T14065 arg2Of collected,were
R11753 T14066 T14067 arg1Of collected,for
R11754 T14068 T14067 arg2Of ELISA,for
R11755 T14068 T14069 arg1Of ELISA,of
R11756 T14068 T14078 arg1Of ELISA,for
R11757 T14069 T14077 arg1Of of,and
R11758 T14070 T14071 arg1Of IL12P70,","
R11759 T14071 T14074 arg1Of ",",and
R11760 T14072 T14071 arg2Of IL6,","
R11761 T14074 T14069 arg2Of and,of
R11762 T14074 T14073 arg1Of and,","
R11763 T14075 T14074 arg2Of GMCSF,and
R11764 T14077 T14076 arg1Of and,","
R11765 T14078 T14077 arg2Of for,and
R11766 T14079 T14078 arg2Of quantification,for
R11767 T14079 T14080 arg1Of quantification,of
R11768 T14082 T14080 arg2Of oxide,of
R11769 T14082 T14081 arg1Of oxide,nitric
R11770 T14082 T14083 arg1Of oxide,(
R11771 T14082 T14107 modOf oxide,dium
R11772 T14084 T14083 arg2Of NO,(
R11773 T14085 T14083 arg3Of ),(
R11774 T14087 T14086 arg2Of (E–,.
R11775 T14088 T14086 arg3Of F,.
R11776 T14090 T14086 arg1Of nt numb,.
R11777 T14090 T14089 arg1Of nt numb,) Gradie
R11778 T14090 T14091 arg1Of nt numb,e
R11779 T14090 T14105 arg1Of nt numb,et
R11780 T14090 T14107 arg1Of nt numb,dium
R11781 T14090 T14108 arg2Of nt numb,) of
R11782 T14092 T14093 arg1Of rs (1,×
R11783 T14093 T14096 arg1Of ×,×10
R11784 T14094 T14093 arg2Of "104, ",×
R11785 T14096 T14091 arg2Of ×10,e
R11786 T14096 T14095 arg1Of ×10,2
R11787 T14098 T14096 arg2Of d 4×1,×10
R11788 T14098 T14097 arg1Of d 4×1,"4, an"
R11789 T14098 T14099 arg1Of d 4×1,04
R11790 T14103 T14099 arg2Of L comp,04
R11791 T14103 T14100 arg1Of L comp,cel
R11792 T14103 T14101 arg1Of L comp,ls
R11793 T14103 T14102 arg1Of L comp,in 0.1 m
R11794 T14104 T14091 arg3Of l,e
R11795 T14106 T14105 arg2Of e me,et
R11796 T14108 T14107 arg2Of ) of,dium
R11797 T14112 T14108 arg3Of for100 ng/m,) of
R11798 T14112 T14109 arg1Of for100 ng/m,BMDC w
R11799 T14112 T14110 arg1Of for100 ng/m,ere u
R11800 T14112 T14111 arg1Of for100 ng/m,sed
R11801 T14114 T14113 arg2Of 24,After
R11802 T14115 T14126 modOf hours,were
R11803 T14115 T14134 arg2Of hours,rescued
R11804 T14115 T14138 arg1Of hours,had
R11805 T14118 T14117 arg1Of amounts,the
R11806 T14118 T14119 arg1Of amounts,of
R11807 T14118 T14123 arg1Of amounts,from
R11808 T14118 T14126 arg1Of amounts,were
R11809 T14118 T14127 arg2Of amounts,measured.
R11810 T14120 T14121 arg1Of IL12P70,and
R11811 T14121 T14119 arg2Of and,of
R11812 T14122 T14121 arg2Of IL6,and
R11813 T14125 T14123 arg2Of supernatant,from
R11814 T14125 T14124 arg1Of supernatant,the
R11815 T14127 T14116 arg1Of measured.,","
R11816 T14127 T14126 arg2Of measured.,were
R11817 T14127 T14128 arg1Of measured.,(
R11818 T14129 T14128 arg2Of G,(
R11819 T14130 T14128 arg3Of ),(
R11820 T14133 T14127 arg3Of mice,measured.
R11821 T14133 T14131 arg1Of mice,The
R11822 T14133 T14132 arg1Of mice,cpdm
R11823 T14137 T14134 arg1Of BAC,rescued
R11824 T14137 T14135 arg2Of BAC,by
R11825 T14137 T14136 arg1Of BAC,Sharpin-containing
R11826 T14138 T14113 arg1Of had,After
R11827 T14138 T14145 arg1Of had,[
R11828 T14140 T14138 arg2Of remission,had
R11829 T14140 T14139 arg1Of remission,complete
R11830 T14140 T14141 arg1Of remission,of
R11831 T14144 T14141 arg2Of phenotype,of
R11832 T14144 T14142 arg1Of phenotype,the
R11833 T14144 T14143 arg1Of phenotype,inflammatory
R11834 T14146 T14145 arg2Of 2,[
R11835 T14147 T14145 arg3Of ],[
R11836 T14148 T14149 arg1Of BMDC,developed
R11837 T14148 T14153 arg1Of BMDC,rescued
R11838 T14148 T14166 arg2Of BMDC,stimulated
R11839 T14149 T14150 arg1Of developed,from
R11840 T14149 T14152 arg1Of developed,and
R11841 T14151 T14150 arg2Of cpdm,from
R11842 T14153 T14161 arg1Of rescued,in
R11843 T14153 T14165 arg1Of rescued,and
R11844 T14154 T14156 modOf cpdm,were
R11845 T14155 T14156 arg1Of mice,were
R11846 T14155 T14157 arg2Of mice,plated
R11847 T14157 T14156 arg2Of plated,were
R11848 T14160 T14153 arg2Of cells,rescued
R11849 T14160 T14154 arg1Of cells,cpdm
R11850 T14160 T14158 arg1Of cells,(
R11851 T14160 T14159 arg1Of cells,1×106
R11852 T14163 T14161 arg2Of mL,in
R11853 T14163 T14162 arg1Of mL,0.3
R11854 T14163 T14164 arg1Of mL,)
R11855 T14165 T14152 arg2Of and,and
R11856 T14166 T14165 arg2Of stimulated,and
R11857 T14166 T14167 arg1Of stimulated,with
R11858 T14168 T14169 arg1Of 100,ng/mL
R11859 T14170 T14167 arg2Of LPS,with
R11860 T14170 T14168 arg1Of LPS,100
R11861 T14173 T14171 arg2Of hours,After
R11862 T14173 T14172 arg1Of hours,24
R11863 T14175 T14176 arg1Of supernatants,were
R11864 T14175 T14177 arg2Of supernatants,collected
R11865 T14177 T14171 arg1Of collected,After
R11866 T14177 T14174 arg1Of collected,","
R11867 T14177 T14176 arg2Of collected,were
R11868 T14177 T14178 arg1Of collected,for
R11869 T14179 T14178 arg2Of analysis,for
R11870 T14179 T14180 arg1Of analysis,of
R11871 T14182 T14180 arg2Of production,of
R11872 T14182 T14181 arg1Of production,IL12P70
R11873 T14183 T14184 arg1Of Data,are
R11874 T14183 T14185 arg1Of Data,representative
R11875 T14185 T14184 arg2Of representative,are
R11876 T14185 T14186 arg1Of representative,of
R11877 T14185 T14193 arg1Of representative,0.01
R11878 T14189 T14186 arg2Of experiments.,of
R11879 T14189 T14187 arg1Of experiments.,three
R11880 T14189 T14188 arg1Of experiments.,independent
R11881 T14193 T14190 arg1Of 0.01,*
R11882 T14193 T14191 arg1Of 0.01,P
R11883 T14193 T14192 arg1Of 0.01,<
R11884 T14193 T14194 arg1Of 0.01,;
R11885 T14198 T14194 arg2Of 0.005,;
R11886 T14198 T14195 arg1Of 0.005,**
R11887 T14198 T14196 arg1Of 0.005,P
R11888 T14198 T14197 arg1Of 0.005,<
R12030 T14390 T14388 arg2Of levels,Decreased
R12031 T14390 T14389 arg1Of levels,mRNA
R12032 T14390 T14391 arg1Of levels,of
R12033 T14393 T14391 arg2Of cytokines,of
R12034 T14393 T14392 arg1Of cytokines,inflammatory
R12035 T14393 T14394 arg1Of cytokines,from
R12036 T14396 T14394 arg2Of BMDC,from
R12037 T14396 T14395 arg1Of BMDC,cpdm
R12038 T14398 T14399 arg1Of WT,and
R12039 T14400 T14399 arg2Of cpdm,and
R12040 T14401 T14397 arg2Of BMDC,Cultured
R12041 T14401 T14398 arg1Of BMDC,WT
R12042 T14401 T14400 arg1Of BMDC,cpdm
R12043 T14401 T14402 arg1Of BMDC,(
R12044 T14401 T14411 arg1Of BMDC,were
R12045 T14401 T14412 arg2Of BMDC,washed
R12046 T14401 T14414 arg2Of BMDC,stimulated
R12047 T14404 T14402 arg2Of cells,(
R12048 T14404 T14403 arg1Of cells,5×105
R12049 T14404 T14405 arg1Of cells,in
R12050 T14409 T14405 arg2Of medium,in
R12051 T14409 T14406 arg1Of medium,0.2
R12052 T14409 T14407 arg1Of medium,ml
R12053 T14409 T14408 arg1Of medium,complete
R12054 T14410 T14402 arg3Of ),(
R12055 T14412 T14413 arg1Of washed,and
R12056 T14413 T14411 arg2Of and,were
R12057 T14413 T14415 arg1Of and,with
R12058 T14414 T14413 arg2Of stimulated,and
R12059 T14416 T14417 arg1Of 100,ng/ml
R12060 T14418 T14416 arg1Of LPS,100
R12061 T14418 T14419 arg1Of LPS,(
R12062 T14418 T14428 arg1Of LPS,or
R12063 T14420 T14421 arg1Of A,","
R12064 T14421 T14423 arg1Of ",",","
R12065 T14422 T14421 arg2Of C,","
R12066 T14423 T14419 arg2Of ",",(
R12067 T14423 T14425 arg1Of ",",","
R12068 T14424 T14423 arg2Of E,","
R12069 T14426 T14425 arg2Of G,","
R12070 T14427 T14419 arg3Of ),(
R12071 T14428 T14415 arg2Of or,with
R12072 T14434 T14428 arg2Of C,or
R12073 T14434 T14429 arg1Of C,25
R12074 T14434 T14430 arg1Of C,µg/ml
R12075 T14434 T14431 arg1Of C,poly
R12076 T14434 T14432 arg1Of C,I
R12077 T14434 T14433 arg1Of C,:
R12078 T14434 T14435 arg1Of C,(
R12079 T14436 T14435 arg2Of B,(
R12080 T14436 T14437 arg1Of B,","
R12081 T14436 T14441 arg1Of B,","
R12082 T14436 T14442 arg1Of B,H
R12083 T14438 T14439 arg1Of D,","
R12084 T14439 T14437 arg2Of ",",","
R12085 T14440 T14439 arg2Of F,","
R12086 T14443 T14435 arg3Of ),(
R12087 T14445 T14446 arg1Of 0,","
R12088 T14446 T14448 arg1Of ",",and
R12089 T14447 T14446 arg2Of 1,","
R12090 T14449 T14448 arg2Of 2,and
R12091 T14450 T14444 arg2Of hours,At
R12092 T14450 T14445 arg1Of hours,0
R12093 T14450 T14447 arg1Of hours,1
R12094 T14450 T14449 arg1Of hours,2
R12095 T14453 T14452 arg1Of RNA,total
R12096 T14453 T14454 arg1Of RNA,was
R12097 T14453 T14455 arg2Of RNA,extracted
R12098 T14453 T14457 arg1Of RNA,subject
R12099 T14455 T14456 arg1Of extracted,and
R12100 T14456 T14444 arg1Of and,At
R12101 T14456 T14451 arg1Of and,","
R12102 T14456 T14454 arg2Of and,was
R12103 T14457 T14456 arg2Of subject,and
R12104 T14457 T14458 arg1Of subject,to
R12105 T14459 T14458 arg2Of qRT-PCR,to
R12106 T14459 T14460 modOf qRT-PCR,to
R12107 T14461 T14460 arg1Of measure,to
R12108 T14463 T14464 arg1Of expression,of
R12109 T14463 T14478 arg1Of expression,","
R12110 T14465 T14466 arg1Of Il12p40,(
R12111 T14465 T14471 arg1Of Il12p40,","
R12112 T14467 T14466 arg2Of A,(
R12113 T14467 T14468 arg1Of A,","
R12114 T14469 T14468 arg2Of B,","
R12115 T14470 T14466 arg3Of ),(
R12116 T14471 T14464 arg2Of ",",of
R12117 T14471 T14473 arg1Of ",",(
R12118 T14472 T14471 arg2Of Il6,","
R12119 T14474 T14473 arg2Of C,(
R12120 T14474 T14475 arg1Of C,","
R12121 T14476 T14475 arg2Of D,","
R12122 T14477 T14473 arg3Of ),(
R12123 T14478 T14461 arg2Of ",",measure
R12124 T14478 T14462 arg1Of ",",the
R12125 T14479 T14480 arg1Of Gmcsf,(
R12126 T14479 T14486 arg1Of Gmcsf,and
R12127 T14481 T14480 arg2Of E,(
R12128 T14481 T14482 arg1Of E,","
R12129 T14483 T14482 arg2Of F,","
R12130 T14484 T14480 arg3Of ),(
R12131 T14486 T14478 arg2Of and,","
R12132 T14486 T14485 arg1Of and,","
R12133 T14487 T14488 arg1Of Ifnb,(
R12134 T14489 T14488 arg2Of G,(
R12135 T14489 T14490 arg1Of G,","
R12136 T14489 T14491 arg1Of G,H
R12137 T14492 T14488 arg3Of ),(
R12138 T14493 T14486 arg2Of mRNA,and
R12139 T14493 T14487 arg1Of mRNA,Ifnb
R12140 T14494 T14495 arg1Of Bars,represent
R12141 T14498 T14495 arg2Of SD,represent
R12142 T14498 T14496 arg1Of SD,mean
R12143 T14498 T14497 arg1Of SD,±
R12144 T14499 T14500 arg1Of Data,are
R12145 T14499 T14501 arg1Of Data,representative
R12146 T14501 T14500 arg2Of representative,are
R12147 T14501 T14502 arg1Of representative,of
R12148 T14505 T14502 arg2Of experiments,of
R12149 T14505 T14503 arg1Of experiments,two
R12150 T14505 T14504 arg1Of experiments,independent
R12302 T14699 T14698 arg1Of TLR4,Normal
R12303 T14699 T14700 arg1Of TLR4,and
R12304 T14700 T14704 arg1Of and,decreased
R12305 T14702 T14700 arg2Of expression,and
R12306 T14702 T14701 arg1Of expression,MD2
R12307 T14704 T14703 arg1Of decreased,and
R12308 T14706 T14705 arg1Of secretion,IL10
R12309 T14706 T14707 arg1Of secretion,and
R12310 T14707 T14704 arg2Of and,decreased
R12311 T14707 T14710 arg1Of and,by
R12312 T14709 T14707 arg2Of expression,and
R12313 T14709 T14708 arg1Of expression,A20
R12314 T14712 T14710 arg2Of BMDC,by
R12315 T14712 T14711 arg1Of BMDC,cpdm
R12316 T14714 T14713 arg2Of A,(
R12317 T14715 T14713 arg3Of ),(
R12318 T14717 T14713 arg1Of WT,(
R12319 T14717 T14716 arg1Of WT,Unstimulated
R12320 T14717 T14718 arg1Of WT,and
R12321 T14718 T14724 arg1Of and,were
R12322 T14718 T14725 arg2Of and,labeled
R12323 T14720 T14718 arg2Of BMDC,and
R12324 T14720 T14719 arg1Of BMDC,cpdm
R12325 T14720 T14721 arg1Of BMDC,(
R12326 T14722 T14721 arg2Of 5×105,(
R12327 T14723 T14721 arg3Of ),(
R12328 T14725 T14724 arg2Of labeled,were
R12329 T14725 T14726 arg1Of labeled,with
R12330 T14725 T14733 arg1Of labeled,subject
R12331 T14728 T14727 arg1Of anti-TLR4/MD2,PE-labeled
R12332 T14728 T14729 arg1Of anti-TLR4/MD2,or
R12333 T14729 T14726 arg2Of or,with
R12334 T14730 T14731 arg1Of anti-CD14,and
R12335 T14731 T14729 arg2Of and,or
R12336 T14732 T14731 arg2Of then,and
R12337 T14733 T14734 modOf subject,to
R12338 T14735 T14734 arg1Of flow,to
R12339 T14737 T14735 arg2Of analysis,flow
R12340 T14737 T14736 arg1Of analysis,cytometry
R12341 T14739 T14738 arg1Of cells,Unstained
R12342 T14739 T14740 arg1Of cells,serve
R12343 T14740 T14741 arg1Of serve,as
R12344 T14745 T14744 arg2Of B,(
R12345 T14746 T14744 arg3Of ),(
R12346 T14747 T14743 arg1Of Cultured,controls.
R12347 T14747 T14744 arg1Of Cultured,(
R12348 T14748 T14749 arg1Of WT,and
R12349 T14749 T14742 arg1Of and,negative
R12350 T14749 T14747 arg1Of and,Cultured
R12351 T14749 T14761 modOf and,were
R12352 T14749 T14776 arg1Of and,:
R12353 T14750 T14749 arg2Of cpdm,and
R12354 T14751 T14752 arg1Of BMDC,(
R12355 T14751 T14761 arg1Of BMDC,were
R12356 T14751 T14762 arg2Of BMDC,washed
R12357 T14751 T14764 arg2Of BMDC,stimulated
R12358 T14754 T14752 arg2Of cells,(
R12359 T14754 T14753 arg1Of cells,1×105
R12360 T14754 T14755 arg1Of cells,in
R12361 T14759 T14755 arg2Of medium,in
R12362 T14759 T14756 arg1Of medium,0.1
R12363 T14759 T14757 arg1Of medium,ml
R12364 T14759 T14758 arg1Of medium,complete
R12365 T14760 T14752 arg3Of ),(
R12366 T14762 T14763 arg1Of washed,and
R12367 T14763 T14761 arg2Of and,were
R12368 T14763 T14765 arg1Of and,with
R12369 T14764 T14763 arg2Of stimulated,and
R12370 T14766 T14767 arg1Of medium,","
R12371 T14767 T14771 arg1Of ",",or
R12372 T14768 T14769 arg1Of 100,ng/ml
R12373 T14770 T14767 arg2Of LPS,","
R12374 T14770 T14768 arg1Of LPS,100
R12375 T14771 T14765 arg2Of or,with
R12376 T14775 T14771 arg2Of I,or
R12377 T14775 T14772 arg1Of I,25
R12378 T14775 T14773 arg1Of I,µg/ml
R12379 T14775 T14774 arg1Of I,poly
R12380 T14777 T14741 arg2Of C,as
R12381 T14777 T14748 arg1Of C,WT
R12382 T14777 T14750 arg1Of C,cpdm
R12383 T14777 T14778 arg1Of C,for
R12384 T14780 T14778 arg2Of hours,for
R12385 T14780 T14779 arg1Of hours,24
R12386 T14781 T14782 arg1Of Supernatants,were
R12387 T14781 T14783 arg2Of Supernatants,collected
R12388 T14783 T14782 arg2Of collected,were
R12389 T14783 T14784 arg1Of collected,for
R12390 T14783 T14818 arg1Of collected,:
R12391 T14785 T14784 arg2Of ELISA,for
R12392 T14785 T14786 arg1Of ELISA,of
R12393 T14785 T14805 modOf ELISA,were
R12394 T14787 T14786 arg2Of IL10.,of
R12395 T14787 T14788 arg1Of IL10.,(
R12396 T14789 T14788 arg2Of C,(
R12397 T14790 T14788 arg3Of ),(
R12398 T14792 T14793 arg1Of WT,and
R12399 T14794 T14793 arg2Of cpdm,and
R12400 T14795 T14791 arg1Of BMDC,Cultured
R12401 T14795 T14792 arg1Of BMDC,WT
R12402 T14795 T14794 arg1Of BMDC,cpdm
R12403 T14795 T14796 arg1Of BMDC,(
R12404 T14795 T14805 arg1Of BMDC,were
R12405 T14795 T14806 arg2Of BMDC,washed
R12406 T14795 T14808 arg2Of BMDC,stimulated
R12407 T14798 T14796 arg2Of cells,(
R12408 T14798 T14797 arg1Of cells,5×105
R12409 T14798 T14799 arg1Of cells,in
R12410 T14803 T14799 arg2Of medium,in
R12411 T14803 T14800 arg1Of medium,0.2
R12412 T14803 T14801 arg1Of medium,ml
R12413 T14803 T14802 arg1Of medium,complete
R12414 T14804 T14796 arg3Of ),(
R12415 T14806 T14807 arg1Of washed,and
R12416 T14807 T14805 arg2Of and,were
R12417 T14807 T14809 arg1Of and,with
R12418 T14808 T14807 arg2Of stimulated,and
R12419 T14810 T14811 arg1Of 100,ng/ml
R12420 T14812 T14810 arg1Of LPS,100
R12421 T14812 T14813 arg1Of LPS,or
R12422 T14813 T14809 arg2Of or,with
R12423 T14816 T14813 arg2Of poly,or
R12424 T14816 T14814 arg1Of poly,25
R12425 T14816 T14815 arg1Of poly,µg/ml
R12426 T14816 T14817 arg1Of poly,I
R12427 T14819 T14838 arg2Of C.,measure
R12428 T14821 T14822 arg1Of 0,","
R12429 T14822 T14825 arg1Of ",",and
R12430 T14823 T14822 arg2Of 1,","
R12431 T14825 T14820 arg2Of and,At
R12432 T14825 T14824 arg1Of and,","
R12433 T14827 T14825 arg2Of hours,and
R12434 T14827 T14826 arg1Of hours,2
R12435 T14830 T14829 arg1Of RNA,total
R12436 T14830 T14831 arg1Of RNA,was
R12437 T14830 T14832 arg2Of RNA,extracted
R12438 T14830 T14834 arg1Of RNA,subject
R12439 T14832 T14833 arg1Of extracted,and
R12440 T14833 T14818 arg2Of and,:
R12441 T14833 T14820 arg1Of and,At
R12442 T14833 T14828 arg1Of and,","
R12443 T14833 T14831 arg2Of and,was
R12444 T14833 T14837 modOf and,to
R12445 T14834 T14833 arg2Of subject,and
R12446 T14834 T14835 arg1Of subject,to
R12447 T14836 T14835 arg2Of qRT-PCR,to
R12448 T14838 T14837 arg1Of measure,to
R12449 T14840 T14838 arg3Of production,measure
R12450 T14840 T14839 arg1Of production,the
R12451 T14840 T14841 arg1Of production,of
R12452 T14842 T14841 arg2Of A20,of
R1248 T1486 T1487 arg1Of SHARPIN,was
R1249 T1486 T1489 arg2Of SHARPIN,identified
R1250 T1489 T1487 arg2Of identified,was
R1251 T1489 T1488 arg1Of identified,originally
R1252 T1489 T1490 arg1Of identified,in
R1253 T1489 T1505 arg1Of identified,but
R12537 T14998 T14999 arg1Of Inhibition,of
R12538 T14998 T15002 arg1Of Inhibition,in
R12539 T15001 T14999 arg2Of signaling,of
R1254 T1492 T1490 arg2Of densities,in
R12540 T15001 T15000 arg1Of signaling,NF-κB
R12541 T15004 T15002 arg2Of BMDC,in
R12542 T15004 T15003 arg1Of BMDC,cpdm
R12543 T15005 T15006 arg1Of WT,and
R12544 T15007 T15006 arg2Of cpdm,and
R12545 T15008 T15005 arg1Of BMDC,WT
R12546 T15008 T15007 arg1Of BMDC,cpdm
R12547 T15008 T15009 arg1Of BMDC,(
R12548 T15008 T15018 arg1Of BMDC,were
R12549 T15008 T15019 arg2Of BMDC,stimulated
R1255 T1492 T1491 arg1Of densities,post-synaptic
R12550 T15011 T15009 arg2Of cells,(
R12551 T15011 T15010 arg1Of cells,2×106
R12552 T15011 T15012 arg1Of cells,in
R12553 T15016 T15012 arg2Of medium,in
R12554 T15016 T15013 arg1Of medium,0.5
R12555 T15016 T15014 arg1Of medium,mL
R12556 T15016 T15015 arg1Of medium,complete
R12557 T15017 T15009 arg3Of ),(
R12558 T15019 T15018 arg2Of stimulated,were
R12559 T15019 T15020 arg1Of stimulated,with
R1256 T1492 T1493 arg1Of densities,of
R12560 T15021 T15022 arg1Of 100,ng/mL
R12561 T15023 T15021 arg1Of LPS,100
R12562 T15023 T15024 arg1Of LPS,(
R12563 T15023 T15027 arg1Of LPS,or
R12564 T15025 T15024 arg2Of A,(
R12565 T15026 T15024 arg3Of ),(
R12566 T15027 T15020 arg2Of or,with
R12567 T15033 T15027 arg2Of C,or
R12568 T15033 T15028 arg1Of C,25
R12569 T15033 T15029 arg1Of C,µg/mL
R1257 T1495 T1493 arg2Of synapses,of
R12570 T15033 T15030 arg1Of C,poly
R12571 T15033 T15031 arg1Of C,I
R12572 T15033 T15032 arg1Of C,:
R12573 T15033 T15034 arg1Of C,(
R12574 T15035 T15034 arg2Of B,(
R12575 T15036 T15034 arg3Of ),(
R12576 T15038 T15039 arg1Of 0,","
R12577 T15039 T15041 arg1Of ",",","
R12578 T15040 T15039 arg2Of 15,","
R12579 T15041 T15044 arg1Of ",",and
R1258 T1495 T1494 arg1Of synapses,excitatory
R12580 T15042 T15041 arg2Of 30,","
R12581 T15044 T15037 arg2Of and,At
R12582 T15044 T15043 arg1Of and,","
R12583 T15046 T15044 arg2Of minutes,and
R12584 T15046 T15045 arg1Of minutes,60
R12585 T15049 T15048 arg1Of lysates,whole-cell
R12586 T15049 T15050 arg1Of lysates,were
R12587 T15049 T15051 arg2Of lysates,obtained
R12588 T15049 T15053 arg1Of lysates,subject
R12589 T15051 T15052 arg1Of obtained,and
R1259 T1495 T1496 arg1Of synapses,in
R12590 T15052 T15037 arg1Of and,At
R12591 T15052 T15047 arg1Of and,","
R12592 T15052 T15050 arg2Of and,were
R12593 T15053 T15052 arg2Of subject,and
R12594 T15053 T15054 arg1Of subject,to
R12595 T15055 T15054 arg2Of immunoblots,to
R12596 T15055 T15056 arg1Of immunoblots,with
R12597 T15057 T15056 arg2Of antibodies,with
R12598 T15057 T15058 arg1Of antibodies,against
R12599 T15059 T15058 arg2Of proteins,against
R1260 T1498 T1496 arg2Of brain,in
R12600 T15059 T15060 arg2Of proteins,involved
R12601 T15060 T15061 arg1Of involved,in
R12602 T15062 T15063 arg1Of NF-κB,","
R12603 T15063 T15065 arg1Of ",",","
R12604 T15064 T15063 arg2Of TBK1/IRF3,","
R12605 T15065 T15068 arg1Of ",",and
R12606 T15066 T15065 arg2Of ERK1/2,","
R12607 T15068 T15067 arg1Of and,","
R12608 T15069 T15068 arg2Of p38,and
R12609 T15071 T15061 arg2Of pathways,in
R1261 T1498 T1497 arg1Of brain,the
R12610 T15071 T15062 arg1Of pathways,NF-κB
R12611 T15071 T15064 arg1Of pathways,TBK1/IRF3
R12612 T15071 T15066 arg1Of pathways,ERK1/2
R12613 T15071 T15069 arg1Of pathways,p38
R12614 T15071 T15070 arg1Of pathways,signaling
R12615 T15072 T15073 arg1Of Beta-actin,was
R12616 T15072 T15074 arg2Of Beta-actin,used
R12617 T15074 T15073 arg2Of used,was
R12618 T15074 T15075 arg1Of used,as
R12619 T15074 T15092 arg1Of used,:
R1262 T1498 T1499 arg1Of brain,of
R12620 T15076 T15075 arg2Of loading,as
R12621 T15079 T15078 arg2Of C,(
R12622 T15080 T15078 arg3Of ),(
R12623 T15082 T15076 arg2Of levels,loading
R12624 T15082 T15077 arg1Of levels,control.
R12625 T15082 T15078 arg1Of levels,(
R12626 T15082 T15081 arg1Of levels,Cellular
R12627 T15082 T15083 arg1Of levels,of
R12628 T15082 T15087 arg1Of levels,in
R12629 T15084 T15085 arg1Of p-IKK1/2,and
R1263 T1500 T1499 arg2Of rats,of
R12630 T15085 T15083 arg2Of and,of
R12631 T15086 T15085 arg2Of p-IκBα,and
R12632 T15088 T15089 arg1Of LPS-,or
R12633 T15089 T15087 arg2Of or,in
R12634 T15090 T15089 arg2Of poly,or
R12635 T15090 T15091 arg1Of poly,I
R12636 T15094 T15093 arg1Of BMDC,C-stimulated
R12637 T15094 T15095 arg1Of BMDC,were
R12638 T15094 T15096 arg2Of BMDC,quantitated
R12639 T15094 T15103 arg2Of BMDC,presented
R1264 T1500 T1501 arg1Of rats,[
R12640 T15096 T15097 arg1Of quantitated,with
R12641 T15096 T15102 arg1Of quantitated,and
R12642 T15098 T15097 arg2Of ImageJ,with
R12643 T15098 T15099 arg1Of ImageJ,(
R12644 T15100 T15099 arg2Of NIH,(
R12645 T15101 T15099 arg3Of ),(
R12646 T15102 T15092 arg2Of and,:
R12647 T15102 T15095 arg2Of and,were
R12648 T15103 T15102 arg2Of presented,and
R12649 T15103 T15104 arg1Of presented,as
R1265 T1502 T1501 arg2Of 1,[
R12650 T15106 T15104 arg2Of lines,as
R12651 T15106 T15105 arg1Of lines,trend
R12652 T15107 T15108 arg1Of Results,are
R12653 T15107 T15109 arg1Of Results,representative
R12654 T15109 T15108 arg2Of representative,are
R12655 T15109 T15110 arg1Of representative,of
R12656 T15113 T15111 arg1Of two,at
R12657 T15113 T15112 arg1Of two,least
R12658 T15115 T15110 arg2Of experiments,of
R12659 T15115 T15113 arg1Of experiments,two
R1266 T1503 T1501 arg3Of ],[
R12660 T15115 T15114 arg1Of experiments,independent
R1267 T1505 T1504 arg1Of but,","
R1268 T1507 T1506 arg1Of protein,this
R1269 T1507 T1508 arg1Of protein,is
R1270 T1507 T1510 arg2Of protein,expressed
R1271 T1510 T1505 arg2Of expressed,but
R1272 T1510 T1508 arg2Of expressed,is
R1273 T1510 T1509 arg1Of expressed,widely
R1274 T1510 T1511 arg1Of expressed,in
R1275 T1513 T1511 arg2Of variety,in
R1276 T1513 T1512 arg1Of variety,a
R1277 T1513 T1514 arg1Of variety,of
R1278 T1515 T1514 arg2Of tissues,of
R1279 T1515 T1516 arg1Of tissues,[
R1280 T1517 T1516 arg2Of 2,[
R12806 T15343 T15341 arg2Of BMDC,Stimulated
R12807 T15343 T15342 arg1Of BMDC,cpdm
R12808 T15343 T15344 arg1Of BMDC,induced
R12809 T15347 T15344 arg2Of production,induced
R1281 T1518 T1516 arg3Of ],[
R12810 T15347 T15345 arg1Of production,Th2-biased
R12811 T15347 T15346 arg1Of production,cytokine
R12812 T15347 T15348 arg1Of production,from
R12813 T15352 T15348 arg2Of cells,from
R12814 T15352 T15349 arg1Of cells,naïve
R12815 T15352 T15350 arg1Of cells,CD4+
R12816 T15352 T15351 arg1Of cells,T
R12817 T15353 T15354 arg1Of WT,and
R12818 T15355 T15354 arg2Of cpdm,and
R12819 T15356 T15353 arg1Of BMDC,WT
R1282 T1520 T1521 arg1Of allelic,","
R12820 T15356 T15355 arg1Of BMDC,cpdm
R12821 T15356 T15357 arg1Of BMDC,(
R12822 T15356 T15371 arg1Of BMDC,were
R12823 T15356 T15372 arg2Of BMDC,incubated
R12824 T15359 T15357 arg2Of cells,(
R12825 T15359 T15358 arg1Of cells,5×104
R12826 T15359 T15360 arg1Of cells,in
R12827 T15359 T15368 arg1Of cells,:
R12828 T15364 T15361 arg1Of medium,0.1
R12829 T15364 T15362 arg1Of medium,mL
R1283 T1522 T1521 arg2Of autosomal,","
R12830 T15364 T15363 arg1Of medium,complete
R12831 T15364 T15365 arg1Of medium,;
R12832 T15365 T15360 arg2Of ;,in
R12833 T15367 T15365 arg2Of haplotype,;
R12834 T15367 T15366 arg1Of haplotype,MHC
R12835 T15369 T15368 arg2Of H-2b,:
R12836 T15370 T15357 arg3Of ),(
R12837 T15372 T15371 arg2Of incubated,were
R12838 T15372 T15373 arg1Of incubated,with
R12839 T15374 T15375 arg1Of medium,","
R1284 T1524 T1519 arg1Of mutations,Two
R12840 T15375 T15379 arg1Of ",",","
R12841 T15378 T15375 arg2Of LPS,","
R12842 T15378 T15376 arg1Of LPS,100
R12843 T15378 T15377 arg1Of LPS,ng/mL
R12844 T15379 T15386 arg1Of ",",or
R12845 T15383 T15382 arg1Of I,poly
R12846 T15383 T15384 arg1Of I,:
R12847 T15385 T15379 arg2Of C,","
R12848 T15385 T15380 arg1Of C,25
R12849 T15385 T15381 arg1Of C,µg/mL
R1285 T1524 T1520 arg1Of mutations,allelic
R12850 T15385 T15383 arg1Of C,I
R12851 T15386 T15373 arg2Of or,with
R12852 T15389 T15386 arg2Of Pam3CYS,or
R12853 T15389 T15387 arg1Of Pam3CYS,5
R12854 T15389 T15388 arg1Of Pam3CYS,µg/mL
R12855 T15392 T15390 arg2Of hours,After
R12856 T15392 T15391 arg1Of hours,24
R12857 T15394 T15395 arg1Of cells,were
R12858 T15394 T15396 arg2Of cells,washed
R12859 T15394 T15400 arg2Of cells,incubated
R1286 T1524 T1522 arg1Of mutations,autosomal
R12860 T15396 T15397 arg1Of washed,with
R12861 T15396 T15399 arg1Of washed,and
R12862 T15398 T15397 arg2Of PBS,with
R12863 T15399 T15390 arg1Of and,After
R12864 T15399 T15393 arg1Of and,","
R12865 T15399 T15395 arg2Of and,were
R12866 T15400 T15399 arg2Of incubated,and
R12867 T15400 T15401 arg1Of incubated,with
R12868 T15403 T15402 arg1Of isolated,freshly
R12869 T15408 T15401 arg2Of cells,with
R1287 T1524 T1523 arg1Of mutations,recessive
R12870 T15408 T15403 arg1Of cells,isolated
R12871 T15408 T15404 arg1Of cells,allogeneic
R12872 T15408 T15405 arg1Of cells,naïve
R12873 T15408 T15406 arg1Of cells,CD4+
R12874 T15408 T15407 arg1Of cells,T
R12875 T15408 T15409 arg1Of cells,(
R12876 T15411 T15409 arg2Of cells,(
R12877 T15411 T15410 arg1Of cells,2.5×105
R12878 T15411 T15412 arg1Of cells,in
R12879 T15411 T15420 arg1Of cells,:
R1288 T1524 T1525 arg1Of mutations,in
R12880 T15416 T15413 arg1Of medium,0.1
R12881 T15416 T15414 arg1Of medium,mL
R12882 T15416 T15415 arg1Of medium,complete
R12883 T15416 T15417 arg1Of medium,;
R12884 T15417 T15412 arg2Of ;,in
R12885 T15419 T15417 arg2Of haplotype,;
R12886 T15419 T15418 arg1Of haplotype,MHC
R12887 T15421 T15420 arg2Of H-2d,:
R12888 T15422 T15409 arg3Of ),(
R12889 T15425 T15423 arg2Of days,After
R1289 T1524 T1529 arg1Of mutations,occurred
R12890 T15425 T15424 arg1Of days,5
R12891 T15427 T15428 arg1Of supernatants,were
R12892 T15427 T15429 arg2Of supernatants,collected
R12893 T15429 T15428 arg2Of collected,were
R12894 T15429 T15430 arg1Of collected,and
R12895 T15430 T15423 arg1Of and,After
R12896 T15430 T15426 arg1Of and,","
R12897 T15432 T15431 arg1Of secretion,the
R12898 T15432 T15433 arg1Of secretion,of
R12899 T15432 T15440 arg1Of secretion,were
R1290 T1528 T1525 arg2Of gene,in
R12900 T15432 T15441 arg2Of secretion,measured
R12901 T15434 T15435 arg1Of IFNγ,","
R12902 T15435 T15438 arg1Of ",",and
R12903 T15436 T15435 arg2Of IL4,","
R12904 T15438 T15433 arg2Of and,of
R12905 T15438 T15437 arg1Of and,","
R12906 T15439 T15438 arg2Of IL2,and
R12907 T15441 T15430 arg2Of measured,and
R12908 T15441 T15440 arg2Of measured,were
R12909 T15443 T15441 arg1Of ELISA,measured
R1291 T1528 T1526 arg1Of gene,the
R12910 T15443 T15442 arg2Of ELISA,by
R12911 T15445 T15444 arg1Of controls,Negative
R12912 T15445 T15446 arg1Of controls,are
R12913 T15447 T15449 arg1Of 1,stimulated
R12914 T15449 T15446 arg2Of stimulated,are
R12915 T15449 T15448 arg1Of stimulated,)
R12916 T15449 T15451 arg1Of stimulated,without
R12917 T15450 T15449 arg2Of BMDC,stimulated
R12918 T15452 T15451 arg2Of co-culture,without
R12919 T15452 T15453 arg1Of co-culture,with
R1292 T1528 T1527 arg1Of gene,Sharpin
R12920 T15457 T15454 arg1Of cells,allogeneic
R12921 T15457 T15455 arg1Of cells,CD4+
R12922 T15457 T15456 arg1Of cells,T
R12923 T15457 T15458 arg1Of cells,;
R12924 T15458 T15453 arg2Of ;,with
R12925 T15459 T15460 arg1Of 2,)
R12926 T15464 T15458 arg2Of cells,;
R12927 T15464 T15459 arg1Of cells,2
R12928 T15464 T15461 arg1Of cells,allogeneic
R12929 T15464 T15462 arg1Of cells,CD4+
R1293 T1529 T1530 arg1Of occurred,spontaneously
R12930 T15464 T15463 arg1Of cells,T
R12931 T15464 T15465 arg1Of cells,without
R12932 T15466 T15465 arg2Of co-culture,without
R12933 T15466 T15467 arg1Of co-culture,with
R12934 T15469 T15467 arg2Of BMDC,with
R12935 T15469 T15468 arg2Of BMDC,stimulated
R12936 T15470 T15471 arg1Of Samples,from
R12937 T15470 T15475 arg1Of Samples,had
R12938 T15474 T15471 arg2Of controls,from
R12939 T15474 T15472 arg1Of controls,both
R1294 T1529 T1531 arg1Of occurred,in
R12940 T15474 T15473 arg1Of controls,negative
R12941 T15478 T15475 arg2Of production,had
R12942 T15478 T15476 arg1Of production,no
R12943 T15478 T15477 arg1Of production,detectable
R12944 T15478 T15479 arg1Of production,of
R12945 T15482 T15479 arg2Of cytokines,of
R12946 T15482 T15480 arg1Of cytokines,the
R12947 T15482 T15481 arg1Of cytokines,aforementioned
R12948 T15482 T15483 arg1Of cytokines,(
R12949 T15485 T15483 arg2Of shown,(
R1295 T1529 T1541 arg1Of occurred,","
R12950 T15485 T15484 arg1Of shown,not
R12951 T15486 T15483 arg3Of ),(
R12952 T15487 T15488 arg1Of Results,are
R12953 T15487 T15489 arg2Of Results,analyzed
R12954 T15489 T15488 arg2Of analyzed,are
R12955 T15489 T15490 arg1Of analyzed,based
R12956 T15491 T15490 arg2Of on,based
R12957 T15493 T15491 arg2Of mice,on
R12958 T15493 T15492 arg1Of mice,2–4
R12959 T15493 T15494 arg1Of mice,per
R1296 T1529 T1542 modOf occurred,resulting
R12960 T15495 T15494 arg2Of group.,per
R12961 T15499 T15489 arg3Of 0.05,analyzed
R12962 T15499 T15496 arg1Of 0.05,*
R12963 T15499 T15497 arg1Of 0.05,P
R12964 T15499 T15498 arg1Of 0.05,<
R1297 T1529 T1556 arg1Of occurred,[
R1298 T1534 T1531 arg2Of strains,in
R1299 T1534 T1532 arg1Of strains,two
R1300 T1534 T1533 arg1Of strains,inbred
R1301 T1534 T1535 arg1Of strains,of
R1302 T1534 T1537 arg1Of strains,","
R1303 T1536 T1535 arg2Of mice,of
R1304 T1538 T1539 arg1Of C57B/KaLawRij-Sharpincpdm/Sharpincpdm,and
R1305 T1539 T1537 arg2Of and,","
R1306 T1540 T1539 arg2Of CBy.Ocb3/Dem-Sharpincpdm-Dem/Sharpincpdm-Dem,and
R1307 T1542 T1543 arg1Of resulting,in
R1308 T1545 T1544 arg1Of termination,premature
R1309 T1545 T1546 arg1Of termination,of
R1310 T1545 T1549 arg1Of termination,and
R1311 T1548 T1546 arg2Of synthesis,of
R1312 T1548 T1547 arg1Of synthesis,mRNA
R1313 T1549 T1543 arg2Of and,in
R1314 T1550 T1549 arg2Of absence,and
R1315 T1550 T1551 arg1Of absence,of
R1316 T1555 T1551 arg2Of product,of
R1317 T1555 T1552 arg1Of product,a
R1318 T1555 T1553 arg1Of product,functional
R1319 T1555 T1554 arg1Of product,protein
R1320 T1557 T1556 arg2Of 2,[
R1321 T1558 T1556 arg3Of ],[
R1322 T1562 T1559 arg2Of backgrounds,Despite
R1323 T1562 T1560 arg1Of backgrounds,different
R1324 T1562 T1561 arg1Of backgrounds,genetic
R1325 T1565 T1564 arg1Of mutations,both
R1326 T1565 T1566 arg1Of mutations,cause
R1327 T1566 T1559 arg1Of cause,Despite
R1328 T1566 T1563 arg1Of cause,","
R1329 T1566 T1586 arg1Of cause,[
R1330 T1569 T1566 arg2Of disease,cause
R1331 T1569 T1567 arg1Of disease,similar
R1332 T1569 T1568 arg1Of disease,inflammatory
R1333 T1569 T1570 arg1Of disease,with
R1334 T1573 T1574 arg1Of progressive,dermatitis
R1335 T1573 T1575 arg1Of progressive,and
R1336 T1576 T1575 arg2Of defective,and
R1337 T1577 T1570 arg2Of development,with
R1338 T1577 T1571 arg1Of development,severe
R1339 T1577 T1572 arg1Of development,chronic
R1340 T1577 T1573 arg1Of development,progressive
R1341 T1577 T1576 arg1Of development,defective
R1342 T1577 T1578 arg1Of development,of
R1343 T1577 T1585 arg1Of development,–
R1344 T1581 T1578 arg2Of organs,of
R1345 T1581 T1579 arg1Of organs,secondary
R1346 T1581 T1580 arg1Of organs,lymphoid
R1347 T1581 T1582 arg1Of organs,[
R1348 T1583 T1582 arg2Of 2,[
R1349 T1584 T1582 arg3Of ],[
R1350 T1587 T1586 arg2Of 4,[
R1351 T1588 T1586 arg3Of ],[
R1352 T1590 T1589 arg1Of dermatitis,The
R1353 T1590 T1591 arg1Of dermatitis,becomes
R1354 T1590 T1593 arg1Of dermatitis,apparent
R1355 T1591 T1594 arg1Of becomes,at
R1356 T1593 T1591 arg2Of apparent,becomes
R1357 T1593 T1592 arg1Of apparent,clinically
R1358 T1596 T1595 arg1Of four,about
R1359 T1597 T1594 arg2Of weeks,at
R1360 T1597 T1596 arg1Of weeks,four
R1361 T1597 T1598 arg1Of weeks,of
R1362 T1599 T1598 arg2Of age,of
R1363 T1600 T1601 arg1Of There,are
R1364 T1602 T1601 arg2Of accumulations,are
R1365 T1602 T1603 arg1Of accumulations,of
R1366 T1602 T1616 arg1Of accumulations,(
R1367 T1602 T1624 arg2Of accumulations,associated
R1368 T1604 T1605 arg1Of eosinophils,","
R1369 T1605 T1607 arg1Of ",",and
R1370 T1606 T1605 arg2Of neutrophils,","
R1371 T1607 T1603 arg2Of and,of
R1372 T1607 T1609 arg1Of and,in
R1373 T1608 T1607 arg2Of macrophages,and
R1374 T1611 T1609 arg2Of skin,in
R1375 T1611 T1610 arg1Of skin,the
R1376 T1611 T1612 arg1Of skin,of
R1377 T1615 T1612 arg2Of mice,of
R1378 T1615 T1613 arg1Of mice,Sharpincpdm/Sharpincpdm
R1379 T1615 T1614 arg1Of mice,mutant
R1380 T1618 T1616 arg2Of referred,(
R1381 T1618 T1617 arg1Of referred,hereafter
R1382 T1618 T1619 arg1Of referred,to
R1383 T1618 T1620 arg1Of referred,as
R1384 T1622 T1620 arg2Of mice,as
R1385 T1622 T1621 arg1Of mice,cpdm
R1386 T1623 T1616 arg3Of ),(
R1387 T1624 T1625 arg1Of associated,with
R1388 T1624 T1635 arg1Of associated,in
R1389 T1625 T1634 arg1Of with,and
R1390 T1627 T1625 arg2Of expression,with
R1391 T1627 T1626 arg2Of expression,increased
R1392 T1627 T1628 arg1Of expression,of
R1393 T1627 T1631 arg1Of expression,in
R1394 T1630 T1628 arg2Of cytokines,of
R1395 T1630 T1629 arg1Of cytokines,Th2
R1396 T1633 T1631 arg2Of skin,in
R1397 T1633 T1632 arg1Of skin,the
R1398 T1635 T1634 arg2Of in,and
R1399 T1637 T1635 arg2Of supernatants,in
R1400 T1637 T1636 arg1Of supernatants,the
R1401 T1637 T1638 arg1Of supernatants,of
R1402 T1640 T1638 arg2Of splenocytes,of
R1403 T1640 T1639 arg2Of splenocytes,activated
R1404 T1640 T1641 arg1Of splenocytes,[
R1405 T1642 T1641 arg2Of 5,[
R1406 T1643 T1641 arg3Of ],[
R1407 T1645 T1644 arg1Of mice,The
R1408 T1645 T1646 arg1Of mice,have
R1409 T1645 T1654 arg1Of mice,decreased
R1410 T1646 T1653 arg1Of have,and
R1411 T1652 T1646 arg2Of response,have
R1412 T1652 T1647 arg1Of response,an
R1413 T1652 T1648 arg1Of response,impaired
R1414 T1652 T1649 arg2Of response,delayed
R1415 T1652 T1650 arg1Of response,type
R1416 T1652 T1651 arg1Of response,hypersensitivity
R1417 T1653 T1658 arg1Of and,[
R1418 T1653 T1661 arg1Of and,","
R1419 T1653 T1662 modOf and,indicating
R1420 T1654 T1653 arg2Of decreased,and
R1421 T1655 T1654 arg2Of secretion,decreased
R1422 T1655 T1656 arg1Of secretion,of
R1423 T1657 T1656 arg2Of IFNγ,of
R1424 T1659 T1658 arg2Of 5,[
R1425 T1660 T1658 arg3Of ],[
R1426 T1664 T1663 arg1Of defect,a
R1427 T1664 T1665 arg1Of defect,in
R1428 T1664 T1669 arg1Of defect,and
R1429 T1668 T1665 arg2Of responses,in
R1430 T1668 T1666 arg1Of responses,Th1
R1431 T1668 T1667 arg1Of responses,immune
R1432 T1669 T1662 arg2Of and,indicating
R1433 T1671 T1669 arg2Of bias,and
R1434 T1671 T1670 arg1Of bias,a
R1435 T1671 T1672 arg1Of bias,towards
R1436 T1676 T1672 arg2Of response,towards
R1437 T1676 T1673 arg1Of response,a
R1438 T1676 T1674 arg1Of response,Th2
R1439 T1676 T1675 arg1Of response,immune
R1440 T1678 T1677 arg1Of treatment,Systemic
R1441 T1678 T1679 arg1Of treatment,of
R1442 T1678 T1682 arg1Of treatment,with
R1443 T1678 T1685 arg1Of treatment,caused
R1444 T1681 T1679 arg2Of mice,of
R1445 T1681 T1680 arg1Of mice,cpdm
R1446 T1684 T1682 arg2Of IL12,with
R1447 T1684 T1683 arg1Of IL12,recombinant
R1448 T1685 T1691 arg1Of caused,[
R1449 T1687 T1685 arg2Of remission,caused
R1450 T1687 T1686 arg1Of remission,complete
R1451 T1687 T1688 arg1Of remission,of
R1452 T1690 T1688 arg2Of dermatitis,of
R1453 T1690 T1689 arg1Of dermatitis,the
R1454 T1692 T1691 arg2Of 5,[
R1455 T1693 T1691 arg3Of ],[
R1456 T1694 T1695 arg1Of Neutralization,of
R1457 T1694 T1697 arg1Of Neutralization,by
R1458 T1694 T1705 arg1Of Neutralization,reduced
R1459 T1694 T1715 arg1Of Neutralization,failed
R1460 T1694 T1717 arg1Of Neutralization,reduce
R1461 T1696 T1695 arg2Of IL5,of
R1462 T1699 T1698 arg1Of treatment,antibody
R1463 T1699 T1700 arg1Of treatment,or
R1464 T1700 T1697 arg2Of or,by
R1465 T1701 T1700 arg2Of crosses,or
R1466 T1701 T1702 arg1Of crosses,with
R1467 T1704 T1702 arg2Of mice,with
R1468 T1704 T1703 arg1Of mice,IL5-deficient
R1469 T1705 T1714 arg1Of reduced,but
R1470 T1707 T1705 arg2Of number,reduced
R1471 T1707 T1706 arg1Of number,the
R1472 T1707 T1708 arg1Of number,of
R1473 T1712 T1708 arg2Of eosinophils,of
R1474 T1712 T1709 arg1Of eosinophils,circulating
R1475 T1712 T1710 arg1Of eosinophils,and
R1476 T1712 T1711 arg1Of eosinophils,cutaneous
R1477 T1714 T1713 arg1Of but,","
R1478 T1715 T1714 arg2Of failed,but
R1479 T1717 T1715 arg2Of reduce,failed
R1480 T1717 T1716 arg1Of reduce,to
R1481 T1717 T1725 arg1Of reduce,[
R1482 T1719 T1720 arg1Of onset,and
R1483 T1720 T1717 arg2Of and,reduce
R1484 T1720 T1718 arg1Of and,the
R1485 T1720 T1722 arg1Of and,of
R1486 T1721 T1720 arg2Of severity,and
R1487 T1724 T1722 arg2Of dermatitis,of
R1488 T1724 T1723 arg1Of dermatitis,the
R1489 T1726 T1725 arg2Of 6,[
R1490 T1727 T1725 arg3Of ],[
R1491 T1732 T1730 arg1Of groups,three
R1492 T1732 T1731 arg1Of groups,independent
R1493 T1732 T1733 arg1Of groups,identified
R1494 T1733 T1728 arg1Of identified,Recently
R1495 T1733 T1729 arg1Of identified,","
R1496 T1733 T1735 arg1Of identified,as
R1497 T1734 T1733 arg2Of SHARPIN,identified
R1498 T1738 T1735 arg2Of component,as
R1499 T1738 T1736 arg1Of component,an
R1500 T1738 T1737 arg1Of component,essential
R1501 T1738 T1739 arg1Of component,of
R1502 T1745 T1739 arg2Of complex,of
R1503 T1745 T1740 arg1Of complex,the
R1504 T1745 T1741 arg1Of complex,linear
R1505 T1745 T1742 arg1Of complex,ubiquitin
R1506 T1745 T1743 arg1Of complex,chain
R1507 T1745 T1744 arg1Of complex,assembly
R1508 T1745 T1746 arg1Of complex,(
R1509 T1745 T1749 arg1Of complex,that
R1510 T1745 T1750 arg1Of complex,regulates
R1511 T1747 T1746 arg2Of LUBAC,(
R1512 T1748 T1746 arg3Of ),(
R1513 T1756 T1755 arg2Of 7,[
R1514 T1757 T1755 arg3Of ],[
R1515 T1758 T1750 arg2Of –,regulates
R1516 T1758 T1751 arg1Of –,TNFα-induced
R1517 T1758 T1752 arg1Of –,canonical
R1518 T1758 T1753 arg1Of –,NF-κB
R1519 T1758 T1754 arg1Of –,signaling
R1520 T1758 T1755 arg1Of –,[
R1521 T1758 T1759 arg1Of –,[
R1522 T1760 T1759 arg2Of 9,[
R1523 T1761 T1759 arg3Of ],[
R1524 T1765 T1762 arg1Of fibroblast,SHARPIN-deficient
R1525 T1765 T1763 arg1Of fibroblast,mouse
R1526 T1765 T1764 arg1Of fibroblast,embryonic
R1527 T1765 T1766 arg1Of fibroblast,(
R1528 T1765 T1769 arg1Of fibroblast,were
R1529 T1765 T1770 arg2Of fibroblast,sensitized
R1530 T1767 T1766 arg2Of MEF,(
R1531 T1768 T1766 arg3Of ),(
R1532 T1770 T1769 arg2Of sensitized,were
R1533 T1770 T1771 arg1Of sensitized,to
R1534 T1770 T1774 arg1Of sensitized,and
R1535 T1773 T1771 arg2Of apoptosis,to
R1536 T1773 T1772 arg1Of apoptosis,TNFα-induced
R1537 T1776 T1775 arg1Of death,cell
R1538 T1776 T1777 arg1Of death,was
R1539 T1776 T1778 arg2Of death,implicated
R1540 T1778 T1774 arg2Of implicated,and
R1541 T1778 T1777 arg2Of implicated,was
R1542 T1778 T1779 arg1Of implicated,as
R1543 T1778 T1792 arg1Of implicated,[
R1544 T1781 T1779 arg2Of factor,as
R1545 T1781 T1780 arg1Of factor,a
R1546 T1781 T1782 arg1Of factor,in
R1547 T1784 T1783 arg1Of dermatitis,the
R1548 T1784 T1785 arg1Of dermatitis,of
R1549 T1784 T1788 arg1Of dermatitis,[
R1550 T1787 T1785 arg2Of mice,of
R1551 T1787 T1786 arg1Of mice,cpdm
R1552 T1789 T1788 arg2Of 7,[
R1553 T1790 T1788 arg3Of ],[
R1554 T1791 T1782 arg2Of –,in
R1555 T1791 T1784 arg1Of –,dermatitis
R1556 T1793 T1792 arg2Of 9,[
R1557 T1794 T1792 arg3Of ],[
R1558 T1796 T1795 arg1Of cells,Dendritic
R1559 T1796 T1797 arg1Of cells,(
R1560 T1796 T1800 arg1Of cells,have
R1561 T1798 T1797 arg2Of DC,(
R1562 T1799 T1797 arg3Of ),(
R1563 T1800 T1804 arg1Of have,in
R1564 T1803 T1800 arg2Of role,have
R1565 T1803 T1801 arg1Of role,a
R1566 T1803 T1802 arg1Of role,sentinel
R1567 T1805 T1804 arg2Of sensing,in
R1568 T1806 T1807 arg1Of pathogen,or
R1569 T1808 T1807 arg2Of danger,or
R1570 T1809 T1810 arg1Of signals,and
R1571 T1810 T1806 arg1Of and,pathogen
R1572 T1810 T1808 arg1Of and,danger
R1573 T1810 T1812 arg1Of and,and
R1574 T1811 T1810 arg2Of initiate,and
R1575 T1812 T1805 arg2Of and,sensing
R1576 T1814 T1812 arg2Of activation,and
R1577 T1814 T1813 arg1Of activation,direct
R1578 T1814 T1815 arg1Of activation,of
R1579 T1819 T1815 arg2Of response,of
R1580 T1819 T1816 arg1Of response,the
R1581 T1819 T1817 arg1Of response,adaptive
R1582 T1819 T1818 arg1Of response,immune
R1583 T1819 T1820 arg1Of response,[
R1584 T1821 T1820 arg2Of 10,[
R1585 T1822 T1820 arg3Of ],[
R1586 T1823 T1824 arg1Of Activated,and
R1587 T1825 T1824 arg2Of mature,and
R1588 T1826 T1823 arg1Of DC,Activated
R1589 T1826 T1825 arg1Of DC,mature
R1590 T1826 T1827 arg1Of DC,can
R1591 T1826 T1828 arg1Of DC,carry
R1592 T1826 T1833 arg1Of DC,migrate
R1593 T1826 T1839 arg1Of DC,induce
R1594 T1828 T1827 arg2Of carry,can
R1595 T1828 T1832 arg1Of carry,","
R1596 T1831 T1828 arg2Of peptides,carry
R1597 T1831 T1829 arg2Of peptides,processed
R1598 T1831 T1830 arg1Of peptides,antigenic
R1599 T1832 T1838 arg1Of ",",and
R1600 T1833 T1832 arg2Of migrate,","
R1601 T1833 T1834 arg1Of migrate,to
R1602 T1836 T1834 arg2Of organs,to
R1603 T1836 T1835 arg1Of organs,lymphoid
R1604 T1838 T1837 arg1Of and,","
R1605 T1839 T1838 arg2Of induce,and
R1606 T1842 T1840 arg1Of responses,T-cell-mediated
R1607 T1842 T1841 arg1Of responses,immune
R1608 T1842 T1843 arg1Of responses,or
R1609 T1843 T1839 arg2Of or,induce
R1610 T1844 T1843 arg2Of tolerance,or
R1611 T1845 T1846 arg1Of DC,direct
R1612 T1846 T1861 arg1Of direct,","
R1613 T1846 T1862 arg1Of direct,through
R1614 T1848 T1847 arg1Of differentiation,the
R1615 T1848 T1849 arg1Of differentiation,of
R1616 T1848 T1854 arg1Of differentiation,and
R1617 T1852 T1849 arg2Of cells,of
R1618 T1852 T1850 arg1Of cells,CD4+
R1619 T1852 T1851 arg1Of cells,T
R1620 T1854 T1846 arg2Of and,direct
R1621 T1854 T1853 arg1Of and,","
R1622 T1857 T1854 arg2Of type,and
R1623 T1857 T1855 arg1Of type,hence
R1624 T1857 T1856 arg1Of type,the
R1625 T1857 T1858 arg1Of type,of
R1626 T1860 T1858 arg2Of response,of
R1627 T1860 T1859 arg1Of response,immune
R1628 T1865 T1862 arg2Of secretion,through
R1629 T1865 T1863 arg1Of secretion,the
R1630 T1865 T1864 arg1Of secretion,selective
R1631 T1865 T1866 arg1Of secretion,of
R1632 T1867 T1866 arg2Of cytokines,of
R1633 T1868 T1869 arg1Of We,hypothesized
R1634 T1873 T1871 arg1Of secretion,defective
R1635 T1873 T1872 arg1Of secretion,cytokine
R1636 T1873 T1874 arg1Of secretion,by
R1637 T1873 T1876 arg1Of secretion,contributed
R1638 T1875 T1874 arg2Of DC,by
R1639 T1876 T1869 arg2Of contributed,hypothesized
R1640 T1876 T1870 arg1Of contributed,that
R1641 T1902 T1900 arg2Of mediators,of
R1642 T1902 T1901 arg1Of mediators,pro-inflammatory
R1643 T1876 T1877 arg1Of contributed,to
R1644 T1903 T1897 arg2Of and,caused
R1645 T1881 T1877 arg2Of phenotype,to
R1646 T1906 T1903 arg2Of activation,and
R1647 T1906 T1904 arg1Of activation,impaired
R1648 T1906 T1905 arg1Of activation,NF-κB
R1649 T1906 T1907 arg1Of activation,upon
R1650 T1881 T1878 arg1Of phenotype,the
R1651 T1881 T1879 arg1Of phenotype,Th2-biased
R1652 T1881 T1880 arg1Of phenotype,inflammatory
R1653 T1909 T1907 arg2Of stimulation,upon
R1654 T1909 T1908 arg1Of stimulation,ligand
R1655 T1881 T1882 arg1Of phenotype,in
R1656 T1884 T1882 arg2Of mice,in
R1657 T1911 T1910 arg1Of ability,The
R1658 T1911 T1912 arg1Of ability,of
R1659 T1911 T1915 modOf ability,to
R1660 T1911 T1925 arg1Of ability,was
R1661 T1911 T1926 arg2Of ability,compromised
R1662 T1914 T1912 arg2Of BMDC,of
R1663 T1914 T1913 arg1Of BMDC,cpdm
R1664 T1916 T1915 arg1Of stimulate,to
R1665 T1884 T1883 arg1Of mice,SHARPIN-deficient
R1666 T1886 T1885 arg1Of studies,The
R1667 T1919 T1916 arg2Of production,stimulate
R1668 T1919 T1917 arg1Of production,Th1
R1669 T1919 T1918 arg1Of production,cytokine
R1670 T1919 T1920 arg1Of production,in
R1671 T1886 T1887 arg2Of studies,reported
R1672 T1886 T1889 arg1Of studies,found
R1673 T1887 T1888 arg1Of reported,here
R1674 T1924 T1920 arg2Of cells,in
R1675 T1924 T1921 arg1Of cells,allogeneic
R1676 T1924 T1922 arg1Of cells,CD4+
R1677 T1924 T1923 arg1Of cells,T
R1678 T1926 T1925 arg2Of compromised,was
R1679 T1927 T1928 arg1Of Taken,together
R1680 T1891 T1892 arg1Of lack,of
R1681 T1931 T1930 arg1Of results,these
R1682 T1931 T1932 arg1Of results,reveal
R1683 T1931 T1944 arg1Of results,suggest
R1684 T1932 T1943 arg1Of reveal,and
R1685 T1934 T1935 arg1Of SHARPIN,is
R1686 T1935 T1932 arg2Of is,reveal
R1687 T1935 T1933 arg1Of is,that
R1688 T1935 T1940 arg1Of is,in
R1689 T1891 T1897 arg1Of lack,caused
R1690 T1894 T1892 arg2Of protein,of
R1691 T1939 T1935 arg2Of molecule,is
R1692 T1939 T1936 arg1Of molecule,a
R1693 T1939 T1937 arg1Of molecule,novel
R1694 T1939 T1938 arg1Of molecule,regulatory
R1695 T1942 T1940 arg2Of biology,in
R1696 T1942 T1941 arg1Of biology,DC
R1697 T1943 T1927 modOf and,Taken
R1698 T1943 T1929 arg1Of and,","
R1699 T1944 T1943 arg2Of suggest,and
R1700 T1894 T1893 arg1Of protein,SHARPIN
R1701 T1894 T1895 arg1Of protein,in
R1702 T1896 T1895 arg2Of BMDC,in
R1703 T1948 T1946 arg1Of function,the
R1704 T1948 T1947 arg2Of function,dysregulated
R1705 T1948 T1949 arg1Of function,of
R1706 T1948 T1952 arg1Of function,plays
R1707 T1897 T1889 arg2Of caused,found
R1708 T1951 T1949 arg2Of DC,of
R1709 T1951 T1950 arg1Of DC,SHARPIN-deficient
R1710 T1952 T1944 arg2Of plays,suggest
R1711 T1952 T1945 arg1Of plays,that
R1712 T1952 T1955 arg1Of plays,in
R1713 T1897 T1890 arg1Of caused,that
R1714 T1954 T1952 arg2Of role,plays
R1715 T1954 T1953 arg1Of role,a
R1716 T1899 T1898 arg1Of expression,defective
R1717 T1958 T1955 arg2Of phenotype,in
R1718 T1958 T1956 arg1Of phenotype,the
R1719 T1958 T1957 arg1Of phenotype,cpdm
R1720 T1899 T1900 arg1Of expression,of
R1721 T1899 T1903 arg1Of expression,and
R2041 T2461 T2462 arg1Of Characterization,of
R2042 T2463 T2462 arg2Of Sharpin,of
R2043 T2464 T2465 arg1Of Orthologs,of
R2044 T2464 T2468 arg1Of Orthologs,are
R2045 T2464 T2469 arg2Of Orthologs,found
R2046 T2467 T2465 arg2Of protein,of
R2047 T2467 T2466 arg1Of protein,SHARPIN
R2048 T2469 T2468 arg2Of found,are
R2049 T2469 T2470 arg1Of found,in
R2050 T2472 T2470 arg2Of species,in
R2051 T2472 T2471 arg1Of species,various
R2052 T2472 T2473 arg1Of species,","
R2053 T2472 T2474 arg1Of species,including
R2054 T2475 T2476 arg1Of human,","
R2055 T2477 T2478 arg1Of mouse,and
R2056 T2478 T2474 arg2Of and,including
R2057 T2478 T2475 arg1Of and,human
R2058 T2479 T2478 arg2Of rat,and
R2059 T2482 T2480 arg1Of programming,Motif
R2060 T2482 T2481 arg1Of programming,prediction
R2061 T2482 T2495 arg1Of programming,suggests
R2062 T2485 T2486 arg1Of COILS,[
R2063 T2485 T2489 arg1Of COILS,and
R2064 T2487 T2486 arg2Of 11,[
R2065 T2488 T2486 arg3Of ],[
R2066 T2489 T2484 arg2Of and,using
R2067 T2490 T2489 arg2Of MotifScan,and
R2068 T2490 T2491 arg1Of MotifScan,[
R2069 T2492 T2491 arg2Of 12,[
R2070 T2493 T2491 arg3Of ],[
R2071 T2495 T2483 arg1Of suggests,","
R2072 T2495 T2484 modOf suggests,using
R2073 T2495 T2494 arg1Of suggests,","
R2074 T2497 T2498 arg1Of SHARPIN,contains
R2075 T2498 T2495 arg2Of contains,suggests
R2076 T2498 T2496 arg1Of contains,that
R2077 T2502 T2501 arg2Of CC,(
R2078 T2503 T2501 arg3Of ),(
R2079 T2504 T2499 arg1Of domain,a
R2080 T2504 T2500 arg1Of domain,coiled-coil
R2081 T2504 T2501 arg1Of domain,(
R2082 T2504 T2505 arg1Of domain,","
R2083 T2504 T2513 arg1Of domain,and
R2084 T2507 T2508 arg1Of ubiquitin-like,(
R2085 T2509 T2508 arg2Of UBL,(
R2086 T2510 T2508 arg3Of ),(
R2087 T2511 T2505 arg2Of domain,","
R2088 T2511 T2506 arg1Of domain,a
R2089 T2511 T2507 arg1Of domain,ubiquitin-like
R2090 T2513 T2498 arg2Of and,contains
R2091 T2513 T2512 arg1Of and,","
R2092 T2520 T2519 arg2Of ZFRBP,(
R2093 T2521 T2519 arg3Of ),(
R2094 T2522 T2513 arg2Of domain,and
R2095 T2522 T2514 arg1Of domain,a
R2096 T2522 T2515 arg1Of domain,zinc-finger
R2097 T2522 T2516 arg1Of domain,Ran-binding
R2098 T2522 T2517 arg1Of domain,protein
R2099 T2522 T2518 arg1Of domain,2
R2100 T2522 T2519 arg1Of domain,(
R2101 T2525 T2523 arg1Of motifs,These
R2102 T2525 T2524 arg1Of motifs,functional
R2103 T2525 T2526 arg1Of motifs,constitute
R2104 T2526 T2545 arg1Of constitute,","
R2105 T2526 T2546 modOf constitute,suggesting
R2106 T2529 T2526 arg2Of profiles,constitute
R2107 T2529 T2527 arg1Of profiles,similar
R2108 T2529 T2528 arg1Of profiles,domain
R2109 T2529 T2530 arg1Of profiles,that
R2110 T2529 T2531 arg1Of profiles,are
R2111 T2529 T2532 arg1Of profiles,present
R2112 T2532 T2531 arg2Of present,are
R2113 T2532 T2533 arg1Of present,in
R2114 T2536 T2533 arg2Of protein,in
R2115 T2536 T2534 arg1Of protein,the
R2116 T2536 T2535 arg1Of protein,SHARPIN
R2117 T2536 T2537 arg1Of protein,of
R2118 T2540 T2537 arg2Of origins,of
R2119 T2540 T2538 arg1Of origins,all
R2120 T2540 T2539 arg1Of origins,three
R2121 T2540 T2541 arg1Of origins,(
R2122 T2543 T2541 arg2Of 1A,(
R2123 T2543 T2542 arg1Of 1A,Fig.
R2124 T2544 T2541 arg3Of ),(
R2125 T2546 T2553 arg1Of suggesting,across
R2126 T2548 T2549 arg1Of SHARPIN,exerts
R2127 T2549 T2546 arg2Of exerts,suggesting
R2128 T2549 T2547 arg1Of exerts,that
R2129 T2552 T2549 arg2Of functions,exerts
R2130 T2552 T2550 arg1Of functions,highly
R2131 T2552 T2551 arg2Of functions,conserved
R2132 T2554 T2553 arg2Of species,across
R2133 T2556 T2555 arg1Of mutations,Spontaneous
R2134 T2556 T2557 arg1Of mutations,in
R2135 T2556 T2562 arg1Of mutations,results
R2136 T2561 T2557 arg2Of gene,in
R2137 T2561 T2558 arg1Of gene,the
R2138 T2561 T2559 arg1Of gene,mouse
R2139 T2561 T2560 arg1Of gene,Sharpin
R2140 T2562 T2563 arg1Of results,in
R2141 T2566 T2565 arg1Of inflammatory,complex
R2142 T2567 T2563 arg2Of phenotype,in
R2143 T2567 T2564 arg1Of phenotype,a
R2144 T2567 T2566 arg1Of phenotype,inflammatory
R2145 T2567 T2568 arg2Of phenotype,characterized
R2146 T2571 T2570 arg1Of dermatitis,severe
R2147 T2571 T2572 arg1Of dermatitis,(
R2148 T2571 T2576 arg1Of dermatitis,","
R2149 T2574 T2572 arg2Of 1B,(
R2150 T2574 T2573 arg1Of 1B,Fig.
R2151 T2575 T2572 arg3Of ),(
R2152 T2576 T2579 arg1Of ",",and
R2153 T2578 T2576 arg2Of inflammation,","
R2154 T2578 T2577 arg1Of inflammation,systemic
R2155 T2579 T2568 arg1Of and,characterized
R2156 T2579 T2569 arg2Of and,by
R2157 T2582 T2579 arg2Of spleen,and
R2158 T2582 T2580 arg1Of spleen,an
R2159 T2582 T2581 arg1Of spleen,enlarged
R2160 T2582 T2583 arg1Of spleen,(
R2161 T2582 T2587 arg2Of spleen,caused
R2162 T2585 T2583 arg2Of 1C,(
R2163 T2585 T2584 arg1Of 1C,Fig.
R2164 T2586 T2583 arg3Of ),(
R2165 T2590 T2587 arg1Of hematopoiesis,caused
R2166 T2590 T2588 arg2Of hematopoiesis,by
R2167 T2590 T2589 arg1Of hematopoiesis,extramedullary
R2168 T2590 T2591 arg1Of hematopoiesis,[
R2169 T2592 T2591 arg2Of 3,[
R2170 T2593 T2591 arg3Of ],[
R2171 T2596 T2594 arg1Of expression,The
R2172 T2596 T2595 arg1Of expression,endogenous
R2173 T2596 T2597 arg1Of expression,of
R2174 T2596 T2600 arg1Of expression,in
R2175 T2596 T2602 arg1Of expression,was
R2176 T2596 T2603 arg2Of expression,determined
R2177 T2599 T2597 arg2Of mRNA,of
R2178 T2599 T2598 arg1Of mRNA,Sharpin
R2179 T2601 T2600 arg2Of BMDC,in
R2180 T2603 T2602 arg2Of determined,was
R2181 T2603 T2611 arg1Of determined,following
R2182 T2603 T2613 arg1Of determined,in
R2183 T2607 T2603 arg1Of time-PCR,determined
R2184 T2607 T2604 arg2Of time-PCR,by
R2185 T2607 T2605 arg1Of time-PCR,quantitative
R2186 T2607 T2606 arg1Of time-PCR,real
R2187 T2607 T2608 arg1Of time-PCR,(
R2188 T2609 T2608 arg2Of qRT-PCR,(
R2189 T2610 T2608 arg3Of ),(
R2190 T2612 T2611 arg2Of culture,following
R2191 T2614 T2613 arg2Of medium,in
R2192 T2615 T2616 arg1Of only,or
R2193 T2616 T2613 arg3Of or,in
R2194 T2617 T2616 arg2Of after,or
R2195 T2618 T2617 arg2Of stimulation,after
R2196 T2618 T2619 arg1Of stimulation,with
R2197 T2620 T2619 arg2Of LPS,with
R2198 T2622 T2621 arg1Of mRNA,Sharpin
R2199 T2622 T2623 arg1Of mRNA,was
R2200 T2622 T2624 arg1Of mRNA,present
R2201 T2623 T2635 arg1Of was,and
R2202 T2624 T2623 arg2Of present,was
R2203 T2624 T2625 arg1Of present,in
R2204 T2626 T2625 arg2Of BMDC,in
R2205 T2626 T2627 arg2Of BMDC,generated
R2206 T2627 T2628 arg1Of generated,from
R2207 T2627 T2631 arg1Of generated,(
R2208 T2630 T2628 arg2Of mice,from
R2209 T2630 T2629 arg1Of mice,WT
R2210 T2633 T2631 arg2Of 1D,(
R2211 T2633 T2632 arg1Of 1D,Fig.
R2212 T2634 T2631 arg3Of ),(
R2213 T2637 T2636 arg1Of level,its
R2214 T2637 T2638 arg1Of level,was
R2215 T2637 T2640 arg2Of level,decreased
R2216 T2640 T2635 arg2Of decreased,and
R2217 T2640 T2638 arg2Of decreased,was
R2218 T2640 T2639 arg1Of decreased,modestly
R2219 T2640 T2641 arg1Of decreased,by
R2220 T2643 T2641 arg2Of stimulation,by
R2221 T2643 T2642 arg1Of stimulation,LPS
R2222 T2644 T2645 arg1Of There,was
R2223 T2645 T2655 arg1Of was,in
R2224 T2648 T2645 arg2Of reduction,was
R2225 T2648 T2646 arg1Of reduction,a
R2226 T2648 T2647 arg1Of reduction,significant
R2227 T2648 T2649 arg1Of reduction,of
R2228 T2651 T2649 arg2Of mRNA,of
R2229 T2651 T2650 arg1Of mRNA,Sharpin
R2230 T2651 T2652 arg1Of mRNA,(
R2231 T2653 T2652 arg2Of 6–7-fold,(
R2232 T2654 T2652 arg3Of ),(
R2233 T2656 T2655 arg2Of BMDC,in
R2234 T2656 T2657 arg2Of BMDC,generated
R2235 T2657 T2658 arg1Of generated,from
R2236 T2660 T2658 arg2Of mice,from
R2237 T2660 T2659 arg1Of mice,cpdm
R2238 T2661 T2662 arg1Of Transfection,of
R2239 T2661 T2665 arg1Of Transfection,in
R2240 T2661 T2675 arg1Of Transfection,indicated
R2241 T2664 T2662 arg2Of Sharpin,of
R2242 T2664 T2663 arg1Of Sharpin,Flag-tagged
R2243 T2666 T2667 arg1Of fibroblasts,(
R2244 T2666 T2670 arg1Of fibroblasts,and
R2245 T2668 T2667 arg2Of NIH3T3,(
R2246 T2669 T2667 arg3Of ),(
R2247 T2670 T2665 arg2Of and,in
R2248 T2671 T2670 arg2Of macrophages,and
R2249 T2671 T2672 arg1Of macrophages,(
R2250 T2673 T2672 arg2Of RAW264.7,(
R2251 T2674 T2672 arg3Of ),(
R2252 T2677 T2675 arg2Of localization,indicated
R2253 T2677 T2676 arg1Of localization,cytoplasmic
R2254 T2677 T2678 arg1Of localization,of
R2255 T2681 T2678 arg2Of protein,of
R2256 T2681 T2679 arg1Of protein,the
R2257 T2681 T2680 arg1Of protein,SHARPIN
R2258 T2681 T2682 arg1Of protein,(
R2259 T2684 T2682 arg2Of 1E,(
R2260 T2684 T2683 arg1Of 1E,Fig.
R2261 T2685 T2682 arg3Of ),(
R2707 T3283 T3281 arg1Of DC,Phenotyping
R2708 T3283 T3282 arg1Of DC,splenic
R2709 T3283 T3284 arg1Of DC,and
R2710 T3285 T3284 arg2Of BMDC,and
R2711 T3285 T3286 arg1Of BMDC,from
R2712 T3287 T3288 arg1Of WT,and
R2713 T3289 T3288 arg2Of cpdm,and
R2714 T3290 T3289 arg1Of mice,cpdm
R2715 T3290 T3286 arg2Of mice,from
R2716 T3290 T3287 arg1Of mice,WT
R2717 T3291 T3292 arg1Of DC,are
R2718 T3291 T3293 arg1Of DC,heterogeneous
R2719 T3291 T3295 arg1Of DC,can
R2720 T3291 T3296 arg1Of DC,be
R2721 T3291 T3297 arg2Of DC,categorized
R2722 T3292 T3294 arg1Of are,and
R2723 T3293 T3292 arg2Of heterogeneous,are
R2724 T3297 T3294 arg2Of categorized,and
R2725 T3297 T3295 arg2Of categorized,can
R2726 T3297 T3296 arg2Of categorized,be
R2727 T3297 T3298 arg1Of categorized,into
R2728 T3300 T3298 arg2Of subtypes,into
R2729 T3300 T3299 arg1Of subtypes,multiple
R2730 T3300 T3301 arg1Of subtypes,based
R2731 T3302 T3301 arg2Of on,based
R2732 T3304 T3302 arg2Of markers,on
R2733 T3304 T3303 arg1Of markers,surface
R2734 T3304 T3305 arg1Of markers,[
R2735 T3306 T3305 arg2Of 13,[
R2736 T3307 T3305 arg3Of ],[
R2737 T3309 T3308 arg1Of determine,To
R2738 T3313 T3311 arg1Of mutation,the
R2739 T3313 T3312 arg1Of mutation,Sharpin
R2740 T3313 T3314 arg1Of mutation,affects
R2741 T3314 T3309 arg2Of affects,determine
R2742 T3314 T3310 arg1Of affects,if
R2743 T3314 T3317 arg1Of affects,in
R2744 T3316 T3314 arg2Of development,affects
R2745 T3316 T3315 arg1Of development,DC
R2746 T3319 T3317 arg2Of tissues,in
R2747 T3319 T3318 arg1Of tissues,lymphoid
R2748 T3322 T3321 arg1Of spleens,mouse
R2749 T3322 T3323 arg1Of spleens,were
R2750 T3322 T3324 arg2Of spleens,examined
R2751 T3324 T3308 modOf examined,To
R2752 T3324 T3320 arg1Of examined,","
R2753 T3324 T3323 arg2Of examined,were
R2754 T3324 T3325 arg1Of examined,for
R2755 T3324 T3349 arg1Of examined,[
R2756 T3327 T3328 arg1Of distribution,of
R2757 T3327 T3331 arg1Of distribution,(
R2758 T3327 T3338 arg1Of distribution,[
R2759 T3327 T3341 arg1Of distribution,and
R2760 T3330 T3328 arg2Of DC,of
R2761 T3330 T3329 arg1Of DC,conventional
R2762 T3332 T3331 arg2Of cDC,(
R2763 T3332 T3333 arg1Of cDC,;
R2764 T3334 T3335 arg1Of CD11c+CD8α+,and
R2765 T3335 T3333 arg2Of and,;
R2766 T3336 T3335 arg2Of CD11c+CD8α−,and
R2767 T3337 T3331 arg3Of ),(
R2768 T3339 T3338 arg2Of 13,[
R2769 T3340 T3338 arg3Of ],[
R2770 T3341 T3325 arg2Of and,for
R2771 T3341 T3326 arg1Of and,the
R2772 T3343 T3341 arg2Of DC,and
R2773 T3343 T3342 arg1Of DC,plasmacytoid
R2774 T3343 T3344 arg1Of DC,(
R2775 T3345 T3344 arg2Of pDC,(
R2776 T3345 T3346 arg1Of pDC,;
R2777 T3345 T3347 arg1Of pDC,CD11c−PDCA-1+
R2778 T3348 T3344 arg3Of ),(
R2779 T3350 T3349 arg2Of 14,[
R2780 T3351 T3349 arg3Of ],[
R2781 T3353 T3352 arg1Of percentages,The
R2782 T3353 T3354 arg1Of percentages,for
R2783 T3353 T3359 arg1Of percentages,were
R2784 T3353 T3361 arg2Of percentages,reduced
R2785 T3353 T3366 arg1Of percentages,compared
R2786 T3356 T3357 arg1Of cDC,and
R2787 T3357 T3354 arg2Of and,for
R2788 T3357 T3355 arg1Of and,splenic
R2789 T3358 T3357 arg2Of pDC,and
R2790 T3361 T3359 arg2Of reduced,were
R2791 T3361 T3360 arg1Of reduced,both
R2792 T3361 T3362 arg1Of reduced,in
R2793 T3361 T3365 arg1Of reduced,when
R2794 T3364 T3362 arg2Of mice,in
R2795 T3364 T3363 arg1Of mice,cpdm
R2796 T3366 T3365 arg2Of compared,when
R2797 T3366 T3367 arg1Of compared,with
R2798 T3369 T3367 arg2Of controls,with
R2799 T3369 T3368 arg1Of controls,WT
R2800 T3369 T3370 arg1Of controls,(
R2801 T3372 T3370 arg2Of 2A,(
R2802 T3372 T3371 arg1Of 2A,Fig.
R2803 T3373 T3370 arg3Of ),(
R2804 T3377 T3376 arg2Of gated,when
R2805 T3377 T3378 arg1Of gated,on
R2806 T3380 T3378 arg2Of cDC,on
R2807 T3380 T3379 arg1Of cDC,CD11c+
R2808 T3383 T3377 arg1Of percentages,gated
R2809 T3383 T3382 arg1Of percentages,the
R2810 T3383 T3384 arg1Of percentages,of
R2811 T3383 T3389 arg1Of percentages,were
R2812 T3383 T3391 arg2Of percentages,affected
R2813 T3388 T3384 arg2Of cells,of
R2814 T3388 T3385 arg1Of cells,CD8α+
R2815 T3388 T3386 arg1Of cells,and
R2816 T3388 T3387 arg1Of cells,CD8α−
R2817 T3391 T3374 arg1Of affected,However
R2818 T3391 T3375 arg1Of affected,","
R2819 T3391 T3376 arg1Of affected,when
R2820 T3391 T3381 arg1Of affected,","
R2821 T3391 T3389 arg2Of affected,were
R2822 T3391 T3390 arg1Of affected,not
R2823 T3394 T3391 arg1Of deficiency,affected
R2824 T3394 T3392 arg2Of deficiency,by
R2825 T3394 T3393 arg1Of deficiency,SHARPIN
R2826 T3394 T3395 arg1Of deficiency,(
R2827 T3397 T3395 arg2Of 2A,(
R2828 T3397 T3396 arg1Of 2A,Fig.
R2829 T3398 T3395 arg3Of ),(
R2830 T3401 T3400 arg1Of spleen,the
R2831 T3401 T3402 arg1Of spleen,of
R2832 T3401 T3405 arg1Of spleen,is
R2833 T3401 T3407 arg2Of spleen,enlarged
R2834 T3401 T3409 arg1Of spleen,contains
R2835 T3404 T3402 arg2Of mice,of
R2836 T3404 T3403 arg1Of mice,cpdm
R2837 T3407 T3405 arg2Of enlarged,is
R2838 T3407 T3406 arg1Of enlarged,markedly
R2839 T3407 T3408 arg1Of enlarged,and
R2840 T3408 T3399 arg2Of and,Since
R2841 T3409 T3408 arg2Of contains,and
R2842 T3409 T3412 arg1Of contains,as
R2843 T3411 T3409 arg2Of times,contains
R2844 T3411 T3410 arg1Of times,three
R2845 T3414 T3412 arg2Of cells,as
R2846 T3414 T3413 arg1Of cells,many
R2847 T3414 T3415 arg1Of cells,(
R2848 T3417 T3415 arg2Of 1C,(
R2849 T3417 T3416 arg1Of 1C,Fig.
R2850 T3418 T3415 arg3Of ),(
R2851 T3422 T3420 arg1Of percentages,the
R2852 T3422 T3421 arg1Of percentages,different
R2853 T3422 T3423 arg1Of percentages,of
R2854 T3422 T3433 arg1Of percentages,reflect
R2855 T3425 T3426 arg1Of cDC,and
R2856 T3426 T3423 arg2Of and,of
R2857 T3426 T3424 arg1Of and,splenic
R2858 T3426 T3428 arg1Of and,between
R2859 T3427 T3426 arg2Of pDC,and
R2860 T3429 T3430 arg1Of WT,and
R2861 T3431 T3430 arg2Of mutant,and
R2862 T3432 T3428 arg2Of mice,between
R2863 T3432 T3429 arg1Of mice,WT
R2864 T3432 T3431 arg1Of mice,mutant
R2865 T3433 T3399 arg1Of reflect,Since
R2866 T3433 T3419 arg1Of reflect,","
R2867 T3436 T3434 arg1Of number,the
R2868 T3436 T3435 arg2Of number,increased
R2869 T3436 T3437 arg1Of number,of
R2870 T3436 T3442 arg1Of number,than
R2871 T3440 T3437 arg2Of cells,of
R2872 T3440 T3438 arg1Of cells,total
R2873 T3440 T3439 arg1Of cells,spleen
R2874 T3442 T3433 arg2Of than,reflect
R2875 T3442 T3441 arg1Of than,rather
R2876 T3444 T3442 arg2Of reduction,than
R2877 T3444 T3443 arg1Of reduction,a
R2878 T3444 T3445 arg1Of reduction,in
R2879 T3446 T3447 arg1Of cDC,and
R2880 T3448 T3447 arg2Of pDC,and
R2881 T3449 T3445 arg2Of numbers,in
R2882 T3449 T3446 arg1Of numbers,cDC
R2883 T3449 T3448 arg1Of numbers,pDC
R2884 T3451 T3450 arg1Of data,These
R2885 T3451 T3452 arg1Of data,indicate
R2886 T3456 T3454 arg1Of mutation,the
R2887 T3456 T3455 arg1Of mutation,Sharpin
R2888 T3456 T3457 arg1Of mutation,does
R2889 T3456 T3459 arg1Of mutation,affect
R2890 T3459 T3452 arg2Of affect,indicate
R2891 T3459 T3453 arg1Of affect,that
R2892 T3459 T3457 arg2Of affect,does
R2893 T3459 T3458 arg1Of affect,not
R2894 T3461 T3459 arg2Of distribution,affect
R2895 T3461 T3460 arg1Of distribution,the
R2896 T3461 T3462 arg1Of distribution,of
R2897 T3466 T3462 arg2Of subsets,of
R2898 T3466 T3463 arg1Of subsets,the
R2899 T3466 T3464 arg2Of subsets,examined
R2900 T3466 T3465 arg1Of subsets,DC
R2901 T3466 T3467 arg1Of subsets,in
R2902 T3469 T3467 arg2Of spleen,in
R2903 T3469 T3468 arg1Of spleen,the
R2904 T3470 T3471 arg1Of BMDC,from
R2905 T3470 T3476 arg1Of BMDC,resemble
R2906 T3473 T3472 arg1Of vitro,in
R2907 T3474 T3471 arg2Of cultures,from
R2908 T3474 T3473 arg1Of cultures,vitro
R2909 T3476 T3475 arg1Of resemble,functionally
R2910 T3476 T3487 arg1Of resemble,","
R2911 T3476 T3488 arg1Of resemble,[
R2912 T3479 T3477 arg1Of DC,non-lymphoid
R2913 T3479 T3478 arg1Of DC,tissue
R2914 T3479 T3480 arg1Of DC,and
R2915 T3480 T3476 arg2Of and,resemble
R2916 T3483 T3480 arg2Of DC,and
R2917 T3483 T3481 arg1Of DC,monocyte-derived
R2918 T3483 T3482 arg1Of DC,inflammatory
R2919 T3483 T3484 arg1Of DC,[
R2920 T3485 T3484 arg2Of 15,[
R2921 T3486 T3484 arg3Of ],[
R2922 T3489 T3488 arg2Of 16,[
R2923 T3490 T3488 arg3Of ],[
R2924 T3492 T3491 arg1Of yields,The
R2925 T3492 T3493 arg1Of yields,of
R2926 T3492 T3500 arg1Of yields,were
R2927 T3492 T3501 arg1Of yields,similar
R2928 T3494 T3493 arg2Of BMDC,of
R2929 T3494 T3495 arg1Of BMDC,from
R2930 T3496 T3497 arg1Of WT,and
R2931 T3498 T3497 arg2Of cpdm,and
R2932 T3499 T3495 arg2Of mice,from
R2933 T3499 T3496 arg1Of mice,WT
R2934 T3499 T3498 arg1Of mice,cpdm
R2935 T3501 T3500 arg2Of similar,were
R2936 T3502 T3503 arg1Of BMDC,were
R2937 T3502 T3504 arg1Of BMDC,CD11c+
R2938 T3502 T3507 arg1Of BMDC,II+
R2939 T3504 T3505 arg1Of CD11c+,and
R2940 T3505 T3503 arg2Of and,were
R2941 T3505 T3508 arg1Of and,with
R2942 T3507 T3505 arg2Of II+,and
R2943 T3507 T3506 arg1Of II+,MHC
R2944 T3510 T3508 arg2Of expression,with
R2945 T3510 T3509 arg1Of expression,low
R2946 T3510 T3511 arg1Of expression,of
R2947 T3514 T3515 arg1Of CD40,","
R2948 T3515 T3518 arg1Of ",",and
R2949 T3516 T3515 arg2Of CD80,","
R2950 T3518 T3511 arg2Of and,of
R2951 T3518 T3512 arg1Of and,co-stimulatory
R2952 T3518 T3513 arg1Of and,molecules
R2953 T3518 T3517 arg1Of and,","
R2954 T3519 T3518 arg2Of CD86,and
R2955 T3524 T3521 arg1Of I,TLR3
R2956 T3524 T3522 arg1Of I,ligand
R2957 T3524 T3523 arg1Of I,poly
R2958 T3524 T3525 arg1Of I,:
R2959 T3526 T3520 arg1Of C,The
R2960 T3526 T3524 arg1Of C,I
R2961 T3526 T3527 arg1Of C,and
R2962 T3527 T3533 arg1Of and,activate
R2963 T3527 T3540 arg1Of and,were
R2964 T3527 T3541 arg2Of and,used
R2965 T3531 T3527 arg2Of LPS,and
R2966 T3531 T3528 arg1Of LPS,the
R2967 T3531 T3529 arg1Of LPS,TLR4
R2968 T3531 T3530 arg1Of LPS,ligand
R2969 T3533 T3532 arg1Of activate,each
R2970 T3533 T3539 arg1Of activate,and
R2971 T3534 T3535 arg1Of overlapping,but
R2972 T3536 T3535 arg2Of different,but
R2973 T3538 T3533 arg2Of pathways,activate
R2974 T3538 T3534 arg1Of pathways,overlapping
R2975 T3538 T3536 arg1Of pathways,different
R2976 T3538 T3537 arg1Of pathways,signaling
R2977 T3539 T3549 arg1Of and,","
R2978 T3539 T3550 arg1Of and,[
R2979 T3541 T3539 arg2Of used,and
R2980 T3541 T3540 arg2Of used,were
R2981 T3543 T3541 arg3Of induce,used
R2982 T3543 T3542 arg1Of induce,to
R2983 T3545 T3543 arg2Of maturation,induce
R2984 T3545 T3544 arg1Of maturation,DC
R2985 T3545 T3546 arg1Of maturation,[
R2986 T3547 T3546 arg2Of 17,[
R2987 T3548 T3546 arg3Of ],[
R2988 T3551 T3550 arg2Of 18,[
R2989 T3552 T3550 arg3Of ],[
R2990 T3553 T3554 arg1Of Incubation,with
R2991 T3553 T3561 arg1Of Incubation,resulted
R2992 T3557 T3554 arg2Of agonists,with
R2993 T3557 T3555 arg1Of agonists,the
R2994 T3557 T3556 arg1Of agonists,TLR
R2995 T3557 T3558 arg1Of agonists,for
R2996 T3560 T3558 arg2Of hours,for
R2997 T3560 T3559 arg1Of hours,24
R2998 T3561 T3562 arg1Of resulted,in
R2999 T3561 T3574 arg1Of resulted,;
R3000 T3564 T3562 arg2Of expression,in
R3001 T3564 T3563 arg2Of expression,increased
R3002 T3564 T3565 arg1Of expression,of
R3003 T3564 T3572 arg1Of expression,on
R3004 T3566 T3567 arg1Of CD40,","
R3005 T3567 T3570 arg1Of ",",and
R3006 T3568 T3567 arg2Of CD80,","
R3007 T3570 T3565 arg2Of and,of
R3008 T3570 T3569 arg1Of and,","
R3009 T3571 T3570 arg2Of CD86,and
R3010 T3573 T3572 arg2Of BMDC,on
R3011 T3577 T3578 arg1Of there,was
R3012 T3578 T3574 arg2Of was,;
R3013 T3578 T3575 arg1Of was,however
R3014 T3578 T3576 arg1Of was,","
R3015 T3580 T3578 arg2Of difference,was
R3016 T3580 T3579 arg1Of difference,no
R3017 T3580 T3581 arg1Of difference,in
R3018 T3580 T3588 arg1Of difference,between
R3019 T3584 T3581 arg2Of levels,in
R3020 T3584 T3582 arg1Of levels,the
R3021 T3584 T3583 arg1Of levels,expression
R3022 T3584 T3585 arg1Of levels,of
R3023 T3587 T3585 arg2Of markers,of
R3024 T3587 T3586 arg1Of markers,these
R3025 T3589 T3590 arg1Of WT,and
R3026 T3590 T3588 arg2Of and,between
R3027 T3592 T3590 arg2Of BMDC,and
R3028 T3592 T3591 arg1Of BMDC,cpdm
R3029 T3592 T3593 arg1Of BMDC,(
R3030 T3595 T3593 arg2Of 2B,(
R3031 T3595 T3594 arg1Of 2B,Fig.
R3032 T3596 T3593 arg3Of ),(
R3033 T3600 T3599 arg1Of deficiency,SHARPIN
R3034 T3600 T3601 arg1Of deficiency,did
R3035 T3600 T3603 arg1Of deficiency,influence
R3036 T3603 T3597 arg1Of influence,Thus
R3037 T3603 T3598 arg1Of influence,","
R3038 T3603 T3601 arg2Of influence,did
R3039 T3603 T3602 arg1Of influence,not
R3040 T3605 T3603 arg2Of expression,influence
R3041 T3605 T3604 arg1Of expression,the
R3042 T3605 T3606 arg1Of expression,of
R3043 T3605 T3609 arg1Of expression,by
R3044 T3608 T3606 arg2Of molecules,of
R3045 T3608 T3607 arg1Of molecules,co-stimulatory
R3046 T3610 T3609 arg2Of BMDC,by
R315 T399 T400 arg1Of SHARPIN,Is
R316 T399 T401 arg1Of SHARPIN,Essential
R317 T401 T400 arg2Of Essential,Is
R318 T401 T402 arg1Of Essential,for
R319 T404 T403 arg1Of Production,Cytokine
R320 T404 T405 arg1Of Production,","
R321 T405 T409 arg1Of ",",and
R322 T407 T405 arg2Of Signaling,","
R323 T407 T406 arg1Of Signaling,NF-κB
R324 T409 T402 arg2Of and,for
R325 T409 T408 arg1Of and,","
R326 T410 T409 arg2Of Induction,and
R327 T410 T411 arg1Of Induction,of
R328 T410 T414 arg1Of Induction,by
R329 T413 T411 arg2Of Differentiation,of
R330 T413 T412 arg1Of Differentiation,Th1
R331 T416 T414 arg2Of Cells,by
R332 T416 T415 arg1Of Cells,Dendritic
R3321 T4014 T4021 arg1Of Production,is
R3322 T4014 T4022 arg2Of Production,impaired
R3323 T4014 T4015 arg1Of Production,of
R3324 T4014 T4018 arg1Of Production,by
R3325 T4017 T4015 arg2Of mediators,of
R3326 T4017 T4016 arg1Of mediators,proinflammatory
R3327 T4020 T4019 arg1Of BMDC,cpdm
R3328 T4020 T4018 arg2Of BMDC,by
R3329 T4022 T4021 arg2Of impaired,is
R333 T418 T417 arg1Of mutations,Spontaneous
R3330 T4023 T4024 arg1Of Incubation,with
R3331 T4023 T4031 arg1Of Incubation,resulted
R3332 T4025 T4026 arg1Of LPS,or
R3333 T4026 T4024 arg2Of or,with
R3334 T4030 T4026 arg2Of C,or
R3335 T4030 T4027 arg1Of C,poly
R3336 T4030 T4028 arg1Of C,I
R3337 T4030 T4029 arg1Of C,:
R3338 T4031 T4032 arg1Of resulted,in
R3339 T4031 T4047 arg1Of resulted,;
R334 T418 T419 arg1Of mutations,of
R3340 T4033 T4032 arg2Of secretion,in
R3341 T4033 T4034 arg1Of secretion,of
R3342 T4033 T4041 arg1Of secretion,from
R3343 T4035 T4036 arg1Of IL6,","
R3344 T4036 T4039 arg1Of ",",and
R3345 T4037 T4036 arg2Of IL12P70,","
R3346 T4039 T4034 arg2Of and,of
R3347 T4039 T4038 arg1Of and,","
R3348 T4040 T4039 arg2Of GMCSF,and
R3349 T4043 T4044 arg1Of WT,and
R335 T426 T419 arg2Of protein,of
R3350 T4044 T4042 arg1Of and,both
R3351 T4045 T4044 arg2Of cpdm,and
R3352 T4046 T4041 arg2Of BMDC,from
R3353 T4046 T4043 arg1Of BMDC,WT
R3354 T4046 T4045 arg1Of BMDC,cpdm
R3355 T4050 T4051 arg1Of BMDC,from
R3356 T4050 T4054 arg1Of BMDC,produced
R3357 T4053 T4051 arg2Of mice,from
R3358 T4053 T4052 arg1Of mice,cpdm
R3359 T4054 T4047 arg2Of produced,;
R336 T426 T420 arg1Of protein,the
R3360 T4054 T4048 arg1Of produced,however
R3361 T4054 T4049 arg1Of produced,","
R3362 T4054 T4055 arg1Of produced,significantly
R3363 T4054 T4061 arg1Of produced,compared
R3364 T4056 T4054 arg2Of less,produced
R3365 T4056 T4057 arg1Of less,of
R3366 T4060 T4057 arg2Of cytokines,of
R3367 T4060 T4058 arg1Of cytokines,all
R3368 T4060 T4059 arg1Of cytokines,three
R3369 T4062 T4061 arg2Of with,compared
R337 T426 T421 arg1Of protein,Sharpin
R3370 T4064 T4062 arg2Of BMDC,with
R3371 T4064 T4063 arg1Of BMDC,WT
R3372 T4064 T4065 arg1Of BMDC,(
R3373 T4067 T4065 arg2Of 3A–C,(
R3374 T4067 T4066 arg1Of 3A–C,Fig.
R3375 T4067 T4068 arg1Of 3A–C,","
R3376 T4069 T4068 arg2Of E–F,","
R3377 T4070 T4065 arg3Of ),(
R3378 T4072 T4071 arg1Of amount,The
R3379 T4072 T4073 arg1Of amount,of
R338 T426 T422 arg1Of protein,(
R3380 T4072 T4080 arg1Of amount,was
R3381 T4075 T4073 arg2Of oxide,of
R3382 T4075 T4074 arg1Of oxide,nitric
R3383 T4075 T4076 arg2Of oxide,generated
R3384 T4076 T4077 arg1Of generated,by
R3385 T4079 T4077 arg2Of BMDC,by
R3386 T4079 T4078 arg1Of BMDC,mutant
R3387 T4080 T4081 arg1Of was,also
R3388 T4080 T4091 arg1Of was,)
R3389 T4080 T4092 arg1Of was,","
R339 T426 T423 arg1Of protein,SHANK-associated
R3390 T4080 T4093 modOf was,indicating
R3391 T4083 T4082 arg1Of reduced,significantly
R3392 T4083 T4084 arg1Of reduced,compared
R3393 T4085 T4084 arg2Of with,compared
R3394 T4087 T4085 arg2Of cells,with
R3395 T4087 T4086 arg1Of cells,WT
R3396 T4090 T4080 arg2Of 3D,was
R3397 T4090 T4083 arg2Of 3D,reduced
R3398 T4090 T4088 arg1Of 3D,(
R3399 T4090 T4089 arg1Of 3D,Fig.
R340 T426 T424 arg1Of protein,RH
R3400 T4096 T4093 arg2Of production,indicating
R3401 T4096 T4094 arg1Of production,severely
R3402 T4096 T4095 arg2Of production,disrupted
R3403 T4096 T4097 arg1Of production,of
R3404 T4099 T4097 arg2Of mediators,of
R3405 T4099 T4098 arg1Of mediators,proinflammatory
R3406 T4099 T4100 arg1Of mediators,from
R3407 T4102 T4100 arg2Of BMDC,from
R3408 T4102 T4101 arg1Of BMDC,Sharpin-deficient
R3409 T4104 T4103 arg1Of vivo,In
R341 T426 T425 arg1Of protein,domain-interacting
R3410 T4105 T4104 arg1Of complementation,vivo
R3411 T4105 T4106 arg1Of complementation,with
R3412 T4105 T4111 arg1Of complementation,reversed
R3413 T4110 T4106 arg2Of BAC,with
R3414 T4110 T4107 arg1Of BAC,a
R3415 T4110 T4108 arg1Of BAC,Sharpin
R3416 T4110 T4109 arg1Of BAC,gene-containing
R3417 T4111 T4122 arg1Of reversed,and
R3418 T4113 T4111 arg2Of phenotype,reversed
R3419 T4113 T4112 arg1Of phenotype,the
R342 T426 T427 arg1Of protein,","
R3420 T4113 T4114 arg1Of phenotype,of
R3421 T4117 T4114 arg2Of mice,of
R3422 T4117 T4115 arg1Of mice,the
R3423 T4117 T4116 arg1Of mice,mutant
R3424 T4117 T4118 arg1Of mice,[
R3425 T4119 T4118 arg2Of 2,[
R3426 T4120 T4118 arg3Of ],[
R3427 T4122 T4121 arg1Of and,","
R3428 T4123 T4124 arg2Of BMDC,generated
R3429 T4123 T4129 arg1Of BMDC,secreted
R343 T429 T427 arg2Of aliases,","
R3430 T4124 T4125 arg1Of generated,from
R3431 T4128 T4125 arg2Of mice,from
R3432 T4128 T4126 arg1Of mice,these
R3433 T4128 T4127 arg2Of mice,rescued
R3434 T4129 T4122 arg2Of secreted,and
R3435 T4129 T4142 arg1Of secreted,","
R3436 T4129 T4143 modOf secreted,supporting
R3437 T4131 T4130 arg1Of more,significantly
R3438 T4132 T4129 arg2Of IL12P70,secreted
R3439 T4132 T4131 arg1Of IL12P70,more
R344 T429 T428 arg1Of aliases,other
R3440 T4132 T4133 arg1Of IL12P70,than
R3441 T4134 T4133 arg2Of BMDC,than
R3442 T4134 T4135 arg1Of BMDC,from
R3443 T4137 T4135 arg2Of mice,from
R3444 T4137 T4136 arg1Of mice,cpdm
R3445 T4137 T4138 arg1Of mice,(
R3446 T4140 T4138 arg2Of 3G,(
R3447 T4140 T4139 arg1Of 3G,Fig.
R3448 T4141 T4138 arg3Of ),(
R3449 T4146 T4143 arg2Of role,supporting
R345 T429 T430 arg1Of aliases,:
R3450 T4146 T4144 arg1Of role,a
R3451 T4146 T4145 arg1Of role,necessary
R3452 T4146 T4147 arg1Of role,of
R3453 T4146 T4149 arg1Of role,for
R3454 T4148 T4147 arg2Of SHARPIN,of
R3455 T4151 T4149 arg2Of production,for
R3456 T4151 T4150 arg1Of production,the
R3457 T4151 T4152 arg1Of production,of
R3458 T4153 T4152 arg2Of IL12P70,of
R3459 T4155 T4154 arg2Of addition,In
R346 T431 T432 arg1Of Rbckl1,","
R3460 T4159 T4157 arg1Of levels,the
R3461 T4159 T4158 arg1Of levels,transcript
R3462 T4159 T4160 arg1Of levels,of
R3463 T4159 T4172 arg1Of levels,were
R3464 T4159 T4173 arg2Of levels,examined
R3465 T4163 T4161 arg1Of cytokines,the
R3466 T4163 T4162 arg1Of cytokines,inflammatory
R3467 T4164 T4165 arg1Of Il6,","
R3468 T4165 T4167 arg1Of ",",","
R3469 T4166 T4165 arg2Of Il12p40,","
R347 T431 T438 arg1Of Rbckl1,result
R3470 T4167 T4170 arg1Of ",",and
R3471 T4168 T4167 arg2Of Gmcsf,","
R3472 T4170 T4160 arg2Of and,of
R3473 T4170 T4163 arg1Of and,cytokines
R3474 T4170 T4169 arg1Of and,","
R3475 T4171 T4170 arg2Of Ifnb,and
R3476 T4173 T4172 arg2Of examined,were
R3477 T4173 T4175 arg1Of examined,and
R3478 T4175 T4154 arg1Of and,In
R3479 T4175 T4156 arg1Of and,","
R348 T433 T432 arg2Of Sipl1,","
R3480 T4175 T4174 arg1Of and,","
R3481 T4176 T4177 arg1Of these,were
R3482 T4176 T4180 arg2Of these,reduced
R3483 T4176 T4186 arg1Of these,compared
R3484 T4180 T4175 arg2Of reduced,and
R3485 T4180 T4177 arg2Of reduced,were
R3486 T4180 T4178 arg1Of reduced,all
R3487 T4180 T4179 arg1Of reduced,significantly
R3488 T4180 T4181 arg1Of reduced,in
R3489 T4180 T4185 arg1Of reduced,when
R349 T433 T434 arg1Of Sipl1,)
R3490 T4184 T4181 arg2Of BMDC,in
R3491 T4184 T4182 arg2Of BMDC,stimulated
R3492 T4184 T4183 arg1Of BMDC,cpdm
R3493 T4186 T4185 arg2Of compared,when
R3494 T4186 T4187 arg1Of compared,with
R3495 T4189 T4187 arg2Of controls,with
R3496 T4189 T4188 arg1Of controls,WT
R3497 T4189 T4190 arg1Of controls,(
R3498 T4191 T4190 arg2Of Fig.,(
R3499 T4191 T4192 arg1Of Fig.,4
R350 T433 T435 arg1Of Sipl1,gene
R3500 T4193 T4190 arg3Of ),(
R351 T433 T436 arg1Of Sipl1,in
R352 T437 T436 arg2Of mice,in
R353 T438 T439 arg1Of result,in
R354 T441 T439 arg2Of inflammation,in
R355 T441 T440 arg1Of inflammation,systemic
R356 T441 T442 arg1Of inflammation,that
R357 T441 T443 arg1Of inflammation,is
R358 T441 T444 arg2Of inflammation,characterized
R359 T444 T443 arg2Of characterized,is
R360 T448 T446 arg1Of dermatitis,chronic
R361 T448 T447 arg1Of dermatitis,proliferative
R362 T448 T449 arg1Of dermatitis,and
R363 T449 T444 arg1Of and,characterized
R364 T449 T445 arg2Of and,by
R365 T451 T449 arg2Of secretion,and
R366 T451 T450 arg2Of secretion,dysregulated
R367 T451 T452 arg1Of secretion,of
R368 T454 T453 arg1Of helper1,T
R369 T454 T455 arg1Of helper1,(
R370 T454 T458 arg1Of helper1,and
R371 T456 T455 arg2Of Th1,(
R372 T457 T455 arg3Of ),(
R373 T459 T458 arg2Of Th2,and
R374 T460 T452 arg2Of cytokines,of
R375 T460 T454 arg1Of cytokines,helper1
R376 T460 T459 arg1Of cytokines,Th2
R377 T462 T463 arg1Of cellular,and
R378 T464 T463 arg2Of molecular,and
R379 T465 T461 arg1Of mechanisms,The
R380 T465 T462 arg1Of mechanisms,cellular
R381 T465 T464 arg1Of mechanisms,molecular
R382 T465 T466 arg1Of mechanisms,underlying
R383 T465 T470 arg1Of mechanisms,remain
R384 T465 T471 arg1Of mechanisms,elusive
R385 T469 T466 arg2Of phenotype,underlying
R386 T469 T467 arg1Of phenotype,this
R387 T469 T468 arg1Of phenotype,inflammatory
R388 T471 T470 arg2Of elusive,remain
R389 T473 T472 arg1Of cells,Dendritic
R390 T473 T474 arg1Of cells,may
R391 T473 T475 arg1Of cells,contribute
R392 T475 T474 arg2Of contribute,may
R393 T475 T476 arg1Of contribute,to
R394 T475 T487 arg1Of contribute,because
R395 T478 T479 arg1Of initiation,and
R396 T479 T476 arg2Of and,to
R397 T479 T477 arg1Of and,the
R398 T479 T481 arg1Of and,of
R399 T480 T479 arg2Of progression,and
R400 T483 T481 arg2Of phenotype,of
R401 T483 T482 arg1Of phenotype,the
R402 T483 T484 arg1Of phenotype,of
R403 T486 T484 arg2Of mice,of
R404 T486 T485 arg1Of mice,SHARPIN-deficient
R4047 T4914 T4912 arg1Of production,Impaired
R4048 T4914 T4913 arg1Of production,cytokine
R4049 T4914 T4915 arg1Of production,by
R405 T487 T488 arg1Of because,of
R4050 T4914 T4918 arg1Of production,is
R4051 T4914 T4919 arg2Of production,correlated
R4052 T4917 T4915 arg2Of BMDC,by
R4053 T4917 T4916 arg1Of BMDC,cpdm
R4054 T4919 T4918 arg2Of correlated,is
R4055 T4919 T4920 arg1Of correlated,with
R4056 T4922 T4920 arg2Of defects,with
R4057 T4922 T4921 arg1Of defects,selective
R4058 T4922 T4923 arg1Of defects,in
R4059 T4925 T4923 arg2Of signaling,in
R406 T491 T487 arg2Of role,because
R4060 T4925 T4924 arg1Of signaling,NF-κB
R4061 T4926 T4927 arg1Of There,are
R4062 T4929 T4927 arg2Of number,are
R4063 T4929 T4928 arg1Of number,a
R4064 T4929 T4930 arg1Of number,of
R4065 T4929 T4933 arg1Of number,for
R4066 T4932 T4930 arg2Of explanations,of
R4067 T4932 T4931 arg1Of explanations,possible
R4068 T4937 T4935 arg1Of secretion,defective
R4069 T4937 T4936 arg1Of secretion,cytokine
R407 T491 T489 arg1Of role,their
R4070 T4937 T4938 arg1Of secretion,in
R4071 T4937 T4942 arg1Of secretion,","
R4072 T4937 T4943 arg1Of secretion,including
R4073 T4937 T4956 arg1Of secretion,)
R4074 T4937 T4965 modOf secretion,increased
R4075 T4937 T4974 arg1Of secretion,and
R4076 T4941 T4938 arg2Of BMDC,in
R4077 T4941 T4939 arg2Of BMDC,stimulated
R4078 T4941 T4940 arg1Of BMDC,cpdm
R4079 T4948 T4943 arg2Of expression,including
R408 T491 T490 arg1Of role,pivotal
R4080 T4948 T4944 arg1Of expression,1
R4081 T4948 T4945 arg1Of expression,)
R4082 T4948 T4946 arg2Of expression,reduced
R4083 T4948 T4947 arg1Of expression,surface
R4084 T4948 T4949 arg1Of expression,of
R4085 T4953 T4949 arg2Of complex,of
R4086 T4953 T4950 arg1Of complex,the
R4087 T4953 T4951 arg1Of complex,LPS
R4088 T4953 T4952 arg1Of complex,receptor
R4089 T4953 T4954 arg1Of complex,","
R409 T491 T492 arg1Of role,in
R4090 T4955 T4954 arg2Of 2,","
R4091 T4958 T4957 arg2Of production,increased
R4092 T4958 T4959 arg1Of production,of
R4093 T4958 T4965 arg1Of production,increased
R4094 T4961 T4959 arg2Of mediators,of
R4095 T4961 T4960 arg1Of mediators,anti-inflammatory
R4096 T4961 T4962 arg1Of mediators,","
R4097 T4961 T4964 arg1Of mediators,)
R4098 T4963 T4962 arg2Of 3,","
R4099 T4966 T4965 arg2Of expression,increased
R410 T493 T494 arg1Of innate,and
R4100 T4966 T4967 arg1Of expression,of
R4101 T4969 T4967 arg2Of regulators,of
R4102 T4969 T4968 arg1Of regulators,negative
R4103 T4969 T4970 arg1Of regulators,of
R4104 T4972 T4970 arg2Of pathways,of
R4105 T4972 T4971 arg1Of pathways,TLR
R4106 T4974 T4933 arg2Of and,for
R4107 T4974 T4934 arg1Of and,the
R4108 T4974 T4973 arg1Of and,","
R4109 T4980 T4974 arg2Of activation,and
R411 T495 T494 arg2Of adaptive,and
R4110 T4980 T4975 arg1Of activation,4
R4111 T4980 T4976 arg1Of activation,)
R4112 T4980 T4977 arg1Of activation,impaired
R4113 T4980 T4978 arg1Of activation,TLR-induced
R4114 T4980 T4979 arg1Of activation,signaling
R4115 T4981 T4982 arg1Of We,determined
R4116 T4985 T4982 arg2Of expression,determined
R4117 T4985 T4983 arg1Of expression,the
R4118 T4985 T4984 arg1Of expression,surface
R4119 T4985 T4986 arg1Of expression,of
R412 T496 T492 arg2Of immunity,in
R4120 T4985 T4991 arg1Of expression,that
R4121 T4985 T4992 arg1Of expression,comprises
R4122 T4990 T4986 arg2Of complex,of
R4123 T4990 T4987 arg1Of complex,the
R4124 T4990 T4988 arg1Of complex,LPS
R4125 T4990 T4989 arg1Of complex,receptor
R4126 T4992 T5007 arg1Of comprises,[
R4127 T4993 T4994 arg1Of TLR4,","
R4128 T4994 T4999 arg1Of ",",and
R4129 T4997 T4995 arg1Of proteins,the
R413 T496 T493 arg1Of immunity,innate
R4130 T4997 T4996 arg1Of proteins,accessory
R4131 T4998 T4994 arg2Of CD14,","
R4132 T4998 T4997 arg1Of CD14,proteins
R4133 T4999 T4992 arg2Of and,comprises
R4134 T5002 T4999 arg2Of factor,and
R4135 T5002 T5000 arg1Of factor,myeloid
R4136 T5002 T5001 arg1Of factor,differentiation
R4137 T5002 T5003 arg1Of factor,2
R4138 T5002 T5004 arg1Of factor,(
R4139 T5005 T5004 arg2Of MD2/LY96,(
R414 T496 T495 arg1Of immunity,adaptive
R4140 T5006 T5004 arg3Of ),(
R4141 T5008 T5007 arg2Of 19,[
R4142 T5009 T5007 arg3Of ],[
R4143 T5012 T5010 arg1Of analysis,Flow
R4144 T5012 T5011 arg1Of analysis,cytometric
R4145 T5012 T5013 arg1Of analysis,shows
R4146 T5017 T5015 arg1Of levels,the
R4147 T5017 T5016 arg1Of levels,expression
R4148 T5017 T5018 arg1Of levels,of
R4149 T5017 T5022 arg1Of levels,between
R415 T498 T499 arg1Of we,show
R4150 T5017 T5027 arg1Of levels,were
R4151 T5017 T5028 arg1Of levels,similar
R4152 T5019 T5020 arg1Of CD14,and
R4153 T5020 T5018 arg2Of and,of
R4154 T5021 T5020 arg2Of TLR4/MD2,and
R4155 T5023 T5024 arg1Of WT,and
R4156 T5024 T5022 arg2Of and,between
R4157 T5026 T5024 arg2Of BMDC,and
R4158 T5026 T5025 arg1Of BMDC,cpdm
R4159 T5027 T5013 arg2Of were,shows
R416 T499 T497 arg1Of show,Here
R4160 T5027 T5014 arg1Of were,that
R4161 T5028 T5027 arg2Of similar,were
R4162 T5028 T5029 arg1Of similar,(
R4163 T5031 T5029 arg2Of 5A,(
R4164 T5031 T5030 arg1Of 5A,Fig.
R4165 T5032 T5029 arg3Of ),(
R4166 T5033 T5035 arg1Of We,quantified
R4167 T5035 T5034 arg1Of quantified,then
R4168 T5037 T5035 arg2Of secretion,quantified
R4169 T5037 T5036 arg1Of secretion,the
R417 T499 T500 arg1Of show,by
R4170 T5037 T5038 arg1Of secretion,of
R4171 T5041 T5039 arg1Of cytokines,the
R4172 T5041 T5040 arg1Of cytokines,suppressive
R4173 T5042 T5038 arg2Of IL10,of
R4174 T5042 T5041 arg1Of IL10,cytokines
R4175 T5042 T5043 arg1Of IL10,that
R4176 T5042 T5044 arg1Of IL10,can
R4177 T5042 T5045 arg1Of IL10,inhibit
R4178 T5045 T5044 arg2Of inhibit,can
R4179 T5045 T5048 arg1Of inhibit,in
R418 T502 T500 arg2Of cytometry,by
R4180 T5045 T5055 arg1Of inhibit,","
R4181 T5045 T5056 arg1Of inhibit,[
R4182 T5047 T5045 arg2Of secretion,inhibit
R4183 T5047 T5046 arg1Of secretion,IL12
R4184 T5051 T5048 arg2Of manner,in
R4185 T5051 T5049 arg1Of manner,an
R4186 T5051 T5050 arg1Of manner,autocrine
R4187 T5051 T5052 arg1Of manner,[
R4188 T5053 T5052 arg2Of 20,[
R4189 T5054 T5052 arg3Of ],[
R419 T502 T501 arg1Of cytometry,flow
R4190 T5057 T5056 arg2Of 21,[
R4191 T5058 T5056 arg3Of ],[
R4192 T5060 T5059 arg1Of supernatants,The
R4193 T5060 T5061 arg1Of supernatants,from
R4194 T5060 T5065 arg1Of supernatants,contained
R4195 T5064 T5061 arg2Of BMDC,from
R4196 T5064 T5062 arg1Of BMDC,LPS-stimulated
R4197 T5064 T5063 arg1Of BMDC,cpdm
R4198 T5065 T5079 arg1Of contained,","
R4199 T5065 T5080 modOf contained,suggesting
R420 T505 T504 arg1Of deficiency,SHARPIN-
R4200 T5067 T5066 arg1Of lower,significantly
R4201 T5068 T5065 arg2Of levels,contained
R4202 T5068 T5067 arg1Of levels,lower
R4203 T5068 T5069 arg1Of levels,of
R4204 T5068 T5071 arg1Of levels,than
R4205 T5070 T5069 arg2Of IL10,of
R4206 T5074 T5071 arg2Of BMDC,than
R4207 T5074 T5072 arg2Of BMDC,stimulated
R4208 T5074 T5073 arg1Of BMDC,WT
R4209 T5074 T5075 arg1Of BMDC,(
R421 T505 T506 arg1Of deficiency,did
R4210 T5077 T5075 arg2Of 5B,(
R4211 T5077 T5076 arg1Of 5B,Fig.
R4212 T5078 T5075 arg3Of ),(
R4213 T5082 T5083 arg1Of IL10,was
R4214 T5082 T5085 arg1Of IL10,responsible
R4215 T5083 T5080 arg2Of was,suggesting
R4216 T5083 T5081 arg1Of was,that
R4217 T5083 T5084 arg1Of was,not
R4218 T5085 T5083 arg2Of responsible,was
R4219 T5085 T5086 arg1Of responsible,for
R422 T505 T508 arg1Of deficiency,alter
R4220 T5088 T5086 arg2Of secretion,for
R4221 T5088 T5087 arg2Of secretion,decreased
R4222 T5088 T5089 arg1Of secretion,of
R4223 T5090 T5089 arg2Of IL12P70,of
R4224 T5090 T5091 arg1Of IL12P70,by
R4225 T5093 T5091 arg2Of BMDC,by
R4226 T5093 T5092 arg1Of BMDC,cpdm
R4227 T5095 T5094 arg2Of expression,Increased
R4228 T5095 T5096 arg1Of expression,of
R4229 T5095 T5109 arg1Of expression,may
R423 T508 T499 arg2Of alter,show
R4230 T5095 T5111 arg1Of expression,suppress
R4231 T5099 T5096 arg2Of regulator,of
R4232 T5099 T5097 arg1Of regulator,a
R4233 T5099 T5098 arg1Of regulator,negative
R4234 T5099 T5100 arg1Of regulator,of
R4235 T5099 T5104 arg1Of regulator,as
R4236 T5102 T5100 arg2Of signaling,of
R4237 T5102 T5101 arg1Of signaling,TLR
R4238 T5104 T5103 arg1Of as,such
R4239 T5105 T5104 arg2Of A20,as
R424 T508 T503 arg1Of alter,that
R4240 T5105 T5106 arg1Of A20,[
R4241 T5107 T5106 arg2Of 22,[
R4242 T5108 T5106 arg3Of ],[
R4243 T5111 T5109 arg2Of suppress,may
R4244 T5111 T5110 arg1Of suppress,also
R4245 T5113 T5111 arg2Of secretion,suppress
R4246 T5113 T5112 arg1Of secretion,cytokine
R4247 T5118 T5116 arg1Of level,the
R4248 T5118 T5117 arg1Of level,transcript
R4249 T5118 T5119 arg1Of level,of
R425 T508 T506 arg2Of alter,did
R4250 T5118 T5121 arg1Of level,was
R4251 T5118 T5122 arg1Of level,lower
R4252 T5118 T5136 arg1Of level,ruling
R4253 T5120 T5119 arg2Of A20,of
R4254 T5121 T5114 arg1Of was,However
R4255 T5121 T5115 arg1Of was,","
R4256 T5121 T5130 arg1Of was,(
R4257 T5121 T5134 arg1Of was,","
R4258 T5121 T5136 modOf was,ruling
R4259 T5122 T5121 arg2Of lower,was
R426 T508 T507 arg1Of alter,not
R4260 T5122 T5123 arg1Of lower,in
R4261 T5122 T5127 arg1Of lower,than
R4262 T5126 T5123 arg2Of BMDC,in
R4263 T5126 T5124 arg1Of BMDC,LPS-activated
R4264 T5126 T5125 arg1Of BMDC,cpdm
R4265 T5129 T5127 arg2Of controls,than
R4266 T5129 T5128 arg1Of controls,WT
R4267 T5132 T5130 arg2Of 5C,(
R4268 T5132 T5131 arg1Of 5C,Fig.
R4269 T5133 T5130 arg3Of ),(
R427 T510 T508 arg2Of distribution,alter
R4270 T5136 T5135 arg1Of ruling,thereby
R4271 T5136 T5137 arg1Of ruling,out
R4272 T5136 T5141 arg1Of ruling,as
R4273 T5138 T5136 arg2Of overexpression,ruling
R4274 T5138 T5139 arg1Of overexpression,of
R4275 T5140 T5139 arg2Of A20,of
R4276 T5143 T5141 arg2Of factor,as
R4277 T5143 T5142 arg1Of factor,a
R4278 T5143 T5144 arg1Of factor,in
R4279 T5148 T5144 arg2Of production,in
R428 T510 T509 arg1Of distribution,the
R4280 T5148 T5145 arg1Of production,the
R4281 T5148 T5146 arg2Of production,reduced
R4282 T5148 T5147 arg1Of production,cytokine
R4283 T5150 T5149 arg1Of transcription,The
R4284 T5150 T5151 arg1Of transcription,of
R4285 T5150 T5155 arg1Of transcription,is
R4286 T5150 T5157 arg2Of transcription,regulated
R4287 T5154 T5151 arg2Of intermediates,of
R4288 T5154 T5152 arg1Of intermediates,TLR3/4-induced
R4289 T5154 T5153 arg1Of intermediates,proinflammatory
R429 T510 T511 arg1Of distribution,of
R4290 T5157 T5155 arg2Of regulated,is
R4291 T5157 T5156 arg1Of regulated,tightly
R4292 T5157 T5162 arg1Of regulated,","
R4293 T5157 T5163 arg1Of regulated,in
R4294 T5161 T5157 arg1Of pathways,regulated
R4295 T5161 T5158 arg2Of pathways,by
R4296 T5161 T5159 arg1Of pathways,cellular
R4297 T5161 T5160 arg1Of pathways,signaling
R4298 T5165 T5164 arg1Of NF-κB,particular
R4299 T5165 T5166 arg1Of NF-κB,","
R430 T514 T511 arg2Of subtypes,of
R4300 T5166 T5169 arg1Of ",",and
R4301 T5167 T5166 arg2Of TBK1/IRF3,","
R4302 T5169 T5163 arg2Of and,in
R4303 T5169 T5168 arg1Of and,","
R4304 T5172 T5171 arg2Of 23,[
R4305 T5173 T5171 arg3Of ],[
R4306 T5174 T5169 arg2Of –,and
R4307 T5174 T5170 arg1Of –,MAPK
R4308 T5174 T5171 arg1Of –,[
R4309 T5174 T5175 arg1Of –,[
R431 T514 T512 arg1Of subtypes,different
R4310 T5176 T5175 arg2Of 27,[
R4311 T5177 T5175 arg3Of ],[
R4312 T5178 T5180 arg1Of We,determined
R4313 T5180 T5179 arg1Of determined,next
R4314 T5180 T5181 arg1Of determined,if
R4315 T5183 T5182 arg2Of NF-κB,disrupted
R4316 T5183 T5184 arg1Of NF-κB,","
R4317 T5184 T5187 arg1Of ",",and/or
R4318 T5185 T5184 arg2Of TBK1/IRF3,","
R4319 T5187 T5186 arg1Of and/or,","
R432 T514 T513 arg1Of subtypes,DC
R4320 T5187 T5190 arg1Of and/or,may
R4321 T5187 T5191 arg1Of and/or,underlie
R4322 T5189 T5187 arg2Of signaling,and/or
R4323 T5189 T5188 arg1Of signaling,MAPK
R4324 T5191 T5181 arg2Of underlie,if
R4325 T5191 T5190 arg2Of underlie,may
R4326 T5195 T5191 arg2Of production,underlie
R4327 T5195 T5192 arg1Of production,the
R4328 T5195 T5193 arg1Of production,impaired
R4329 T5195 T5194 arg1Of production,cytokine
R433 T514 T515 arg1Of subtypes,in
R4330 T5195 T5196 arg1Of production,from
R4331 T5199 T5196 arg2Of BMDC,from
R4332 T5199 T5197 arg2Of BMDC,stimulated
R4333 T5199 T5198 arg1Of BMDC,Sharpin-deficient
R4334 T5201 T5200 arg1Of phosphorylation,Stimulus-induced
R4335 T5201 T5202 arg1Of phosphorylation,of
R4336 T5201 T5209 arg1Of phosphorylation,is
R4337 T5205 T5202 arg2Of kinase,of
R4338 T5205 T5203 arg1Of kinase,the
R4339 T5205 T5204 arg1Of kinase,IκB
R434 T517 T515 arg2Of spleen,in
R4340 T5205 T5206 arg1Of kinase,(
R4341 T5207 T5206 arg2Of IKK1/2,(
R4342 T5208 T5206 arg3Of ),(
R4343 T5209 T5216 arg1Of is,","
R4344 T5209 T5217 modOf is,allowing
R4345 T5212 T5209 arg2Of step,is
R4346 T5212 T5210 arg1Of step,an
R4347 T5212 T5211 arg1Of step,essential
R4348 T5212 T5213 arg1Of step,in
R4349 T5215 T5213 arg2Of signaling,in
R435 T517 T516 arg1Of spleen,the
R4350 T5215 T5214 arg1Of signaling,NF-κB
R4351 T5218 T5219 arg1Of phosphorylation,and
R4352 T5219 T5217 arg2Of and,allowing
R4353 T5219 T5222 arg1Of and,of
R4354 T5219 T5228 arg1Of and,release
R4355 T5221 T5219 arg2Of degradation,and
R4356 T5221 T5220 arg1Of degradation,proteasome-mediated
R4357 T5226 T5222 arg2Of IκBα,of
R4358 T5226 T5223 arg1Of IκBα,the
R4359 T5226 T5224 arg1Of IκBα,NF-κB
R436 T519 T518 arg2Of response,In
R4360 T5226 T5225 arg1Of IκBα,inhibitor
R4361 T5228 T5217 arg3Of release,allowing
R4362 T5228 T5227 arg1Of release,to
R4363 T5228 T5233 arg1Of release,into
R4364 T5232 T5228 arg2Of factors,release
R4365 T5232 T5229 arg1Of factors,the
R4366 T5232 T5230 arg1Of factors,NF-κB
R4367 T5232 T5231 arg1Of factors,transcription
R4368 T5235 T5233 arg2Of nucleus,into
R4369 T5235 T5234 arg1Of nucleus,the
R437 T519 T520 arg1Of response,to
R4370 T5237 T5236 arg1Of amount,The
R4371 T5237 T5238 arg1Of amount,of
R4372 T5237 T5249 arg1Of amount,following
R4373 T5237 T5258 arg1Of amount,was
R4374 T5237 T5260 arg2Of amount,decreased
R4375 T5240 T5239 arg2Of IKK1/2,phosphorylated
R4376 T5240 T5241 arg1Of IKK1/2,(
R4377 T5240 T5244 arg1Of IKK1/2,and
R4378 T5242 T5241 arg2Of p-IKK1/2,(
R4379 T5243 T5241 arg3Of ),(
R438 T524 T523 arg2Of TLR,(
R4380 T5244 T5238 arg2Of and,of
R4381 T5245 T5244 arg2Of IκBα,and
R4382 T5245 T5246 arg1Of IκBα,(
R4383 T5247 T5246 arg2Of p-IκBα,(
R4384 T5248 T5246 arg3Of ),(
R4385 T5250 T5251 arg1Of incubation,with
R4386 T5250 T5253 arg1Of incubation,or
R4387 T5252 T5251 arg2Of LPS,with
R4388 T5253 T5249 arg2Of or,following
R4389 T5257 T5253 arg2Of C,or
R439 T525 T523 arg3Of ),(
R4390 T5257 T5254 arg1Of C,poly
R4391 T5257 T5255 arg1Of C,I
R4392 T5257 T5256 arg1Of C,:
R4393 T5260 T5258 arg2Of decreased,was
R4394 T5260 T5259 arg1Of decreased,severely
R4395 T5260 T5261 arg1Of decreased,in
R4396 T5260 T5264 arg1Of decreased,as
R4397 T5263 T5261 arg2Of BMDC,in
R4398 T5263 T5262 arg1Of BMDC,cpdm
R4399 T5265 T5264 arg2Of compared,as
R440 T527 T521 arg1Of LPS,TOLL-like
R4400 T5265 T5266 arg1Of compared,with
R4401 T5268 T5266 arg2Of controls,with
R4402 T5268 T5267 arg1Of controls,WT
R4403 T5268 T5269 arg1Of controls,(
R4404 T5270 T5269 arg2Of Fig.,(
R4405 T5270 T5271 arg1Of Fig.,6
R4406 T5272 T5269 arg3Of ),(
R4407 T5275 T5273 arg1Of BMDC,The
R4408 T5275 T5274 arg1Of BMDC,cpdm
R4409 T5275 T5276 arg1Of BMDC,exhibited
R441 T527 T522 arg1Of LPS,receptor
R4410 T5276 T5287 arg1Of exhibited,to
R4411 T5278 T5276 arg2Of levels,exhibited
R4412 T5278 T5277 arg1Of levels,similar
R4413 T5278 T5279 arg1Of levels,of
R4414 T5280 T5281 arg1Of TBK1,","
R4415 T5281 T5284 arg1Of ",",and
R4416 T5282 T5281 arg2Of ERK1/2,","
R4417 T5284 T5279 arg2Of and,of
R4418 T5284 T5283 arg1Of and,","
R4419 T5286 T5284 arg2Of phosphorylation,and
R442 T527 T523 arg1Of LPS,(
R4420 T5286 T5285 arg1Of phosphorylation,p38
R4421 T5288 T5287 arg2Of those,to
R4422 T5288 T5289 arg1Of those,of
R4423 T5291 T5289 arg2Of cells,of
R4424 T5291 T5290 arg1Of cells,WT
R4425 T5291 T5292 arg1Of cells,(
R4426 T5293 T5292 arg2Of Fig.,(
R4427 T5293 T5294 arg1Of Fig.,6
R4428 T5295 T5292 arg3Of ),(
R4429 T5297 T5296 arg1Of results,These
R443 T527 T526 arg1Of LPS,agonists
R4430 T5297 T5298 arg1Of results,indicate
R4431 T5301 T5300 arg1Of absence,the
R4432 T5301 T5302 arg1Of absence,of
R4433 T5301 T5305 arg1Of absence,decreased
R4434 T5301 T5309 arg1Of absence,did
R4435 T5301 T5311 arg1Of absence,affect
R4436 T5304 T5302 arg2Of SHARPIN,of
R4437 T5304 T5303 arg1Of SHARPIN,functional
R4438 T5305 T5308 arg1Of decreased,but
R4439 T5307 T5305 arg2Of activation,decreased
R444 T527 T528 arg1Of LPS,and
R4440 T5307 T5306 arg1Of activation,NF-κB
R4441 T5308 T5298 arg2Of but,indicate
R4442 T5308 T5299 arg1Of but,that
R4443 T5311 T5308 arg2Of affect,but
R4444 T5311 T5309 arg2Of affect,did
R4445 T5311 T5310 arg1Of affect,not
R4446 T5312 T5313 arg1Of TBK1/IRF3,","
R4447 T5313 T5316 arg1Of ",",and
R4448 T5314 T5313 arg2Of ERK1/2,","
R4449 T5316 T5311 arg2Of and,affect
R445 T528 T520 arg2Of and,to
R4450 T5316 T5315 arg1Of and,","
R4451 T5316 T5319 arg1Of and,in
R4452 T5318 T5316 arg2Of signaling,and
R4453 T5318 T5317 arg1Of signaling,p38
R4454 T5320 T5319 arg2Of BMDC,in
R446 T530 T531 arg1Of I,:
R447 T531 T528 arg2Of :,and
R448 T531 T529 arg1Of :,poly
R449 T532 T531 arg2Of C,:
R450 T538 T534 arg2Of cells,cultured
R451 T538 T535 arg1Of cells,bone
R452 T538 T536 arg1Of cells,marrow-derived
R453 T538 T537 arg1Of cells,dendritic
R454 T538 T539 arg1Of cells,(
R455 T538 T542 arg1Of cells,from
R456 T538 T547 arg1Of cells,exhibited
R457 T540 T539 arg2Of BMDC,(
R458 T541 T539 arg3Of ),(
R459 T543 T544 arg1Of WT,and
R460 T545 T544 arg2Of mutant,and
R461 T546 T542 arg2Of mice,from
R462 T546 T543 arg1Of mice,WT
R463 T546 T545 arg1Of mice,mutant
R464 T547 T518 arg1Of exhibited,In
R465 T547 T533 arg1Of exhibited,","
R466 T549 T547 arg2Of increases,exhibited
R467 T549 T548 arg1Of increases,similar
R468 T549 T550 arg1Of increases,in
R469 T551 T550 arg2Of expression,in
R470 T551 T552 arg1Of expression,of
R471 T555 T556 arg1Of CD40,","
R472 T556 T559 arg1Of ",",and
R473 T557 T556 arg2Of CD80,","
R474 T559 T552 arg2Of and,of
R475 T559 T553 arg1Of and,co-stimulatory
R476 T559 T554 arg1Of and,molecules
R477 T559 T558 arg1Of and,","
R478 T560 T559 arg2Of CD86,and
R479 T565 T563 arg1Of BMDC,stimulated
R480 T565 T564 arg1Of BMDC,SHARPIN-deficient
R481 T565 T566 arg1Of BMDC,had
R482 T565 T567 arg1Of BMDC,reduced
R483 T567 T561 arg1Of reduced,However
R484 T567 T562 arg1Of reduced,","
R485 T567 T566 arg2Of reduced,had
R486 T568 T569 arg1Of transcription,and
R487 T569 T567 arg2Of and,reduced
R488 T569 T571 arg1Of and,of
R489 T570 T569 arg2Of secretion,and
R490 T573 T572 arg1Of mediators,pro-inflammatory
R491 T574 T575 arg1Of IL6,","
R492 T575 T577 arg1Of ",",","
R493 T576 T575 arg2Of IL12P70,","
R494 T577 T580 arg1Of ",",and
R495 T578 T577 arg2Of GMCSF,","
R4958 T6138 T6137 arg1Of immunogenicity,Th2-biased
R4959 T6138 T6139 arg1Of immunogenicity,of
R496 T580 T571 arg2Of and,of
R4960 T6142 T6139 arg2Of BMDC,of
R4961 T6142 T6140 arg2Of BMDC,stimulated
R4962 T6142 T6141 arg1Of BMDC,cpdm
R4963 T6146 T6143 arg1Of production,The
R4964 T6146 T6144 arg1Of production,defective
R4965 T6146 T6145 arg1Of production,IL12
R4966 T6146 T6147 arg1Of production,(
R4967 T6146 T6151 arg1Of production,and
R4968 T6149 T6147 arg2Of 3A,(
R4969 T6149 T6148 arg1Of 3A,Fig.
R497 T580 T573 arg1Of and,mediators
R4970 T6150 T6147 arg3Of ),(
R4971 T6151 T6161 arg1Of and,suggest
R4972 T6154 T6151 arg2Of profile,and
R4973 T6154 T6152 arg1Of profile,Th2-dominant
R4974 T6154 T6153 arg1Of profile,cytokine
R4975 T6154 T6155 arg1Of profile,in
R4976 T6157 T6155 arg2Of mice,in
R4977 T6157 T6156 arg1Of mice,cpdm
R4978 T6157 T6158 arg1Of mice,[
R4979 T6159 T6158 arg2Of 5,[
R498 T580 T579 arg1Of and,","
R4980 T6160 T6158 arg3Of ],[
R4981 T6164 T6163 arg1Of absence,the
R4982 T6164 T6165 arg1Of absence,of
R4983 T6164 T6167 arg1Of absence,affects
R4984 T6166 T6165 arg2Of SHARPIN,of
R4985 T6167 T6161 arg2Of affects,suggest
R4986 T6167 T6162 arg1Of affects,that
R4987 T6169 T6167 arg2Of ability,affects
R4988 T6169 T6168 arg1Of ability,the
R4989 T6169 T6170 arg1Of ability,of
R499 T582 T580 arg2Of oxide,and
R4990 T6169 T6173 modOf ability,to
R4991 T6172 T6170 arg2Of BMDC,of
R4992 T6172 T6171 arg1Of BMDC,cpdm
R4993 T6174 T6173 arg1Of induce,to
R4994 T6174 T6178 arg1Of induce,into
R4995 T6177 T6174 arg2Of differentiation,induce
R4996 T6177 T6175 arg1Of differentiation,T
R4997 T6177 T6176 arg1Of differentiation,cell
R4998 T6180 T6178 arg2Of cells,into
R4999 T6180 T6179 arg1Of cells,effector
R500 T582 T581 arg1Of oxide,nitric
R5000 T6181 T6182 arg1Of Co-culture,of
R5001 T6181 T6188 arg1Of Co-culture,with
R5002 T6181 T6199 arg1Of Co-culture,elicited
R5003 T6187 T6182 arg2Of cells,of
R5004 T6187 T6183 arg1Of cells,allogeneic
R5005 T6187 T6184 arg1Of cells,naïve
R5006 T6187 T6185 arg1Of cells,CD4+
R5007 T6187 T6186 arg1Of cells,T
R5008 T6190 T6189 arg1Of BMDC,WT
R5009 T6190 T6191 arg2Of BMDC,stimulated
R501 T584 T583 arg1Of BMDC,Mutant
R5010 T6190 T6194 arg1Of BMDC,or
R5011 T6191 T6192 arg1Of stimulated,with
R5012 T6193 T6192 arg2Of LPS,with
R5013 T6194 T6188 arg2Of or,with
R5014 T6198 T6194 arg2Of C,or
R5015 T6198 T6195 arg1Of C,poly
R5016 T6198 T6196 arg1Of C,I
R5017 T6198 T6197 arg1Of C,:
R5018 T6199 T6203 arg1Of elicited,","
R5019 T6199 T6204 arg1Of elicited,whereas
R502 T584 T585 arg1Of BMDC,had
R5020 T6202 T6199 arg2Of production,elicited
R5021 T6202 T6200 arg1Of production,robust
R5022 T6202 T6201 arg1Of production,IFNγ
R5023 T6206 T6205 arg1Of concentration,the
R5024 T6206 T6207 arg1Of concentration,of
R5025 T6206 T6209 arg1Of concentration,in
R5026 T6206 T6214 arg1Of concentration,was
R5027 T6206 T6216 arg1Of concentration,lower
R5028 T6208 T6207 arg2Of IFNγ,of
R5029 T6213 T6209 arg2Of cultures,in
R503 T585 T592 arg1Of had,whereas
R5030 T6213 T6210 arg1Of cultures,cpdm
R5031 T6213 T6211 arg1Of cultures,BMDC-T
R5032 T6213 T6212 arg1Of cultures,cell
R5033 T6214 T6204 arg2Of was,whereas
R5034 T6214 T6217 arg1Of was,after
R5035 T6214 T6224 arg1Of was,","
R5036 T6214 T6225 modOf was,indicating
R5037 T6216 T6214 arg2Of lower,was
R5038 T6216 T6215 arg1Of lower,significantly
R5039 T6219 T6217 arg2Of stimulation,after
R504 T587 T585 arg2Of activation,had
R5040 T6219 T6218 arg1Of stimulation,LPS
R5041 T6219 T6220 arg1Of stimulation,(
R5042 T6222 T6220 arg2Of 7A,(
R5043 T6222 T6221 arg1Of 7A,Fig.
R5044 T6223 T6220 arg3Of ),(
R5045 T6227 T6226 arg1Of Th1-polarizing,impaired
R5046 T6228 T6225 arg2Of abilities,indicating
R5047 T6228 T6227 arg1Of abilities,Th1-polarizing
R5048 T6228 T6229 arg1Of abilities,of
R5049 T6231 T6229 arg2Of BMDC,of
R505 T587 T586 arg1Of activation,defective
R5050 T6231 T6230 arg1Of BMDC,cpdm
R5051 T6232 T6234 arg1Of In,to
R5052 T6233 T6232 arg2Of addition,In
R5053 T6236 T6232 arg3Of agonists,In
R5054 T6236 T6235 arg1Of agonists,TLR3/4
R5055 T6241 T6238 arg1Of Pam3CYS,the
R5056 T6241 T6239 arg1Of Pam3CYS,TLR2
R5057 T6241 T6240 arg1Of Pam3CYS,ligand
R5058 T6241 T6242 arg1Of Pam3CYS,was
R5059 T6241 T6243 arg2Of Pam3CYS,used
R506 T587 T588 arg1Of activation,of
R5060 T6243 T6232 arg1Of used,In
R5061 T6243 T6237 arg1Of used,","
R5062 T6243 T6242 arg2Of used,was
R5063 T6243 T6244 arg1Of used,since
R5064 T6245 T6246 arg1Of it,has
R5065 T6245 T6247 arg1Of it,been
R5066 T6245 T6248 arg2Of it,shown
R5067 T6245 T6250 arg1Of it,induce
R5068 T6248 T6244 arg2Of shown,since
R5069 T6248 T6246 arg2Of shown,has
R507 T590 T588 arg2Of signaling,of
R5070 T6248 T6247 arg2Of shown,been
R5071 T6250 T6248 arg3Of induce,shown
R5072 T6250 T6249 arg1Of induce,to
R5073 T6250 T6260 arg1Of induce,[
R5074 T6252 T6253 arg1Of Th1,and
R5075 T6254 T6253 arg2Of Th2,and
R5076 T6255 T6250 arg2Of responses,induce
R5077 T6255 T6251 arg1Of responses,both
R5078 T6255 T6252 arg1Of responses,Th1
R5079 T6255 T6254 arg1Of responses,Th2
R508 T590 T589 arg1Of signaling,NF-κB
R5080 T6255 T6256 arg1Of responses,[
R5081 T6255 T6259 arg1Of responses,–
R5082 T6257 T6256 arg2Of 28,[
R5083 T6258 T6256 arg3Of ],[
R5084 T6261 T6260 arg2Of 30,[
R5085 T6262 T6260 arg3Of ],[
R5086 T6265 T6263 arg1Of BMDC,Pam3CYS-matured
R5087 T6265 T6264 arg1Of BMDC,WT
R5088 T6265 T6266 arg1Of BMDC,induced
R5089 T6269 T6266 arg2Of production,induced
R509 T592 T591 arg1Of whereas,","
R5090 T6269 T6267 arg1Of production,robust
R5091 T6269 T6268 arg1Of production,IFNγ
R5092 T6269 T6270 arg1Of production,at
R5093 T6269 T6275 arg1Of production,than
R5094 T6273 T6272 arg1Of higher,significantly
R5095 T6274 T6270 arg2Of level,at
R5096 T6274 T6271 arg1Of level,a
R5097 T6274 T6273 arg1Of level,higher
R5098 T6277 T6275 arg2Of BMDC,than
R5099 T6277 T6276 arg1Of BMDC,cpdm
R510 T594 T593 arg1Of MAPK1/3,the
R5100 T6277 T6278 arg1Of BMDC,(
R5101 T6280 T6278 arg2Of 7A,(
R5102 T6280 T6279 arg1Of 7A,Fig.
R5103 T6281 T6278 arg3Of ),(
R5104 T6285 T6282 arg1Of differentiation,The
R5105 T6285 T6283 arg2Of differentiation,reduced
R5106 T6285 T6284 arg1Of differentiation,Th1
R5107 T6285 T6286 arg1Of differentiation,following
R5108 T6285 T6289 arg1Of differentiation,is
R5109 T6285 T6290 arg1Of differentiation,consistent
R511 T594 T595 arg1Of MAPK1/3,(
R5110 T6288 T6286 arg2Of stimulation,following
R5111 T6288 T6287 arg1Of stimulation,Pam3CYS
R5112 T6290 T6289 arg2Of consistent,is
R5113 T6290 T6291 arg1Of consistent,with
R5114 T6294 T6291 arg2Of report,with
R5115 T6294 T6292 arg1Of report,the
R5116 T6294 T6293 arg1Of report,recent
R5117 T6294 T6295 arg1Of report,of
R5118 T6294 T6299 arg1Of report,in
R5119 T6298 T6295 arg2Of production,of
R512 T594 T598 arg1Of MAPK1/3,and
R5120 T6298 T6296 arg2Of production,decreased
R5121 T6298 T6297 arg1Of production,IL12
R5122 T6301 T6299 arg2Of macrophages,in
R5123 T6301 T6300 arg1Of macrophages,cpdm
R5124 T6301 T6302 arg1Of macrophages,following
R5125 T6304 T6302 arg2Of stimulation,following
R5126 T6304 T6303 arg1Of stimulation,TLR2
R5127 T6304 T6305 arg1Of stimulation,[
R5128 T6306 T6305 arg2Of 31,[
R5129 T6307 T6305 arg3Of ],[
R513 T596 T595 arg2Of ERK1/2,(
R5130 T6309 T6308 arg2Of contrast,In
R5131 T6312 T6311 arg1Of Th2-specific,more
R5132 T6314 T6312 arg1Of cytokine,Th2-specific
R5133 T6314 T6313 arg1Of cytokine,IL4
R5134 T6314 T6315 arg1Of cytokine,was
R5135 T6314 T6316 arg2Of cytokine,produced
R5136 T6316 T6308 arg1Of produced,In
R5137 T6316 T6310 arg1Of produced,","
R5138 T6316 T6315 arg2Of produced,was
R5139 T6316 T6317 arg1Of produced,in
R514 T597 T595 arg3Of ),(
R5140 T6316 T6330 arg1Of produced,","
R5141 T6321 T6317 arg2Of co-cultures,in
R5142 T6321 T6318 arg1Of co-cultures,the
R5143 T6321 T6319 arg1Of co-cultures,cpdm
R5144 T6321 T6320 arg1Of co-cultures,BMDC
R5145 T6321 T6322 arg1Of co-cultures,than
R5146 T6325 T6322 arg2Of control,than
R5147 T6325 T6323 arg1Of control,the
R5148 T6325 T6324 arg1Of control,WT
R5149 T6325 T6326 arg1Of control,(
R515 T598 T610 arg1Of and,were
R5150 T6328 T6326 arg2Of 7B,(
R5151 T6328 T6327 arg1Of 7B,Fig.
R5152 T6329 T6326 arg3Of ),(
R5153 T6331 T6316 arg3Of suggesting,produced
R5154 T6333 T6331 arg2Of immunogenicity,suggesting
R5155 T6333 T6332 arg1Of immunogenicity,Th2-skewed
R5156 T6333 T6334 arg1Of immunogenicity,of
R5157 T6336 T6334 arg2Of BMDC,of
R5158 T6336 T6335 arg1Of BMDC,cpdm
R5159 T6338 T6337 arg1Of production,The
R516 T598 T611 arg1Of and,intact
R5160 T6338 T6339 arg1Of production,of
R5161 T6338 T6343 arg1Of production,following
R5162 T6338 T6349 arg1Of production,was
R5163 T6338 T6350 arg1Of production,similar
R5164 T6342 T6339 arg2Of IL17A,of
R5165 T6342 T6340 arg1Of IL17A,Th17-specific
R5166 T6342 T6341 arg1Of IL17A,cytokine
R5167 T6345 T6343 arg2Of stimulation,following
R5168 T6345 T6344 arg1Of stimulation,LPS
R5169 T6345 T6346 arg1Of stimulation,of
R517 T599 T600 arg1Of MAPK11/12/13/14,(
R5170 T6348 T6346 arg2Of cells,of
R5171 T6348 T6347 arg1Of cells,dendritic
R5172 T6349 T6351 arg1Of was,between
R5173 T6350 T6349 arg2Of similar,was
R5174 T6353 T6352 arg2Of WT,stimulated
R5175 T6353 T6354 arg1Of WT,and
R5176 T6354 T6351 arg2Of and,between
R5177 T6357 T6354 arg2Of cocultures,and
R5178 T6357 T6355 arg1Of cocultures,cpdm
R5179 T6357 T6356 arg1Of cocultures,BMDC
R518 T599 T606 arg1Of MAPK11/12/13/14,and
R5180 T6357 T6358 arg1Of cocultures,(
R5181 T6359 T6358 arg2Of data,(
R5182 T6359 T6361 arg2Of data,shown
R5183 T6361 T6360 arg1Of shown,not
R5184 T6362 T6358 arg3Of ),(
R5185 T6365 T6366 arg1Of distinct,Th1-
R5186 T6365 T6367 arg1Of distinct,and
R5187 T6368 T6367 arg2Of Th2-stimulating,and
R5188 T6369 T6363 arg2Of abilities,Despite
R5189 T6369 T6364 arg1Of abilities,the
R519 T604 T600 arg2Of isoforms,(
R5190 T6369 T6365 arg1Of abilities,distinct
R5191 T6369 T6368 arg1Of abilities,Th2-stimulating
R5192 T6369 T6370 arg1Of abilities,of
R5193 T6371 T6372 arg1Of WT,and
R5194 T6373 T6372 arg2Of cpdm,and
R5195 T6374 T6370 arg2Of BMDC,of
R5196 T6374 T6371 arg1Of BMDC,WT
R5197 T6374 T6373 arg1Of BMDC,cpdm
R5198 T6376 T6377 arg1Of they,were
R5199 T6376 T6379 arg1Of they,effective
R520 T604 T601 arg1Of isoforms,p38
R5200 T6377 T6363 arg1Of were,Despite
R5201 T6377 T6375 arg1Of were,","
R5202 T6379 T6377 arg2Of effective,were
R5203 T6379 T6378 arg1Of effective,equally
R5204 T6379 T6380 arg1Of effective,in
R5205 T6382 T6380 arg2Of production,in
R5206 T6382 T6381 arg1Of production,IL2
R5207 T6382 T6383 arg1Of production,from
R5208 T6382 T6388 arg1Of production,for
R5209 T6382 T6394 arg1Of production,where
R521 T604 T602 arg1Of isoforms,MAP
R5210 T6386 T6383 arg2Of co-cultures,from
R5211 T6386 T6384 arg1Of co-cultures,BMDC-T
R5212 T6386 T6385 arg1Of co-cultures,cell
R5213 T6388 T6387 arg1Of for,except
R5214 T6390 T6391 arg1Of I,:
R5215 T6392 T6391 arg2Of C,:
R5216 T6393 T6388 arg2Of stimulation,for
R5217 T6393 T6389 arg1Of stimulation,poly
R5218 T6393 T6390 arg1Of stimulation,I
R5219 T6393 T6392 arg1Of stimulation,C
R522 T604 T603 arg1Of isoforms,kinase
R5220 T6396 T6395 arg1Of BMDC,WT
R5221 T6396 T6397 arg1Of BMDC,induced
R5222 T6397 T6394 arg2Of induced,where
R5223 T6399 T6397 arg2Of IL2,induced
R5224 T6399 T6398 arg1Of IL2,more
R5225 T6399 T6400 arg1Of IL2,than
R5226 T6402 T6400 arg2Of BMDC,than
R5227 T6402 T6401 arg1Of BMDC,cpdm
R5228 T6402 T6403 arg1Of BMDC,(
R5229 T6405 T6403 arg2Of 7C,(
R523 T605 T600 arg3Of ),(
R5230 T6405 T6404 arg1Of 7C,Fig.
R5231 T6406 T6403 arg3Of ),(
R5232 T6410 T6407 arg1Of capability,The
R5233 T6410 T6408 arg1Of capability,Th2-biased
R5234 T6410 T6409 arg1Of capability,stimulating
R5235 T6410 T6411 arg1Of capability,of
R5236 T6410 T6415 arg1Of capability,co-cultured
R5237 T6410 T6422 arg1Of capability,is
R5238 T6410 T6423 arg1Of capability,consistent
R5239 T6413 T6411 arg2Of BMDC,of
R524 T606 T598 arg2Of and,and
R5240 T6413 T6412 arg1Of BMDC,cpdm
R5241 T6415 T6414 arg2Of co-cultured,when
R5242 T6415 T6416 arg1Of co-cultured,with
R5243 T6421 T6416 arg2Of cells,with
R5244 T6421 T6417 arg1Of cells,allogeneic
R5245 T6421 T6418 arg1Of cells,naïve
R5246 T6421 T6419 arg1Of cells,CD4+
R5247 T6421 T6420 arg1Of cells,T
R5248 T6422 T6414 arg1Of is,when
R5249 T6423 T6422 arg2Of consistent,is
R525 T609 T606 arg2Of pathways,and
R5250 T6423 T6424 arg1Of consistent,with
R5251 T6428 T6424 arg2Of phenotype,with
R5252 T6428 T6425 arg1Of phenotype,the
R5253 T6428 T6426 arg1Of phenotype,Th2-dominant
R5254 T6428 T6427 arg1Of phenotype,cytokine
R5255 T6428 T6429 arg2Of phenotype,observed
R5256 T6429 T6430 arg1Of observed,in
R5257 T6432 T6430 arg2Of mice,in
R5258 T6432 T6431 arg1Of mice,cpdm
R526 T609 T607 arg1Of pathways,TBK1
R527 T609 T608 arg1Of pathways,signaling
R528 T610 T592 arg2Of were,whereas
R529 T611 T610 arg2Of intact,were
R530 T615 T612 arg1Of reaction,A
R531 T615 T613 arg1Of reaction,mixed
R532 T615 T614 arg1Of reaction,lymphocyte
R533 T615 T616 arg1Of reaction,showed
R534 T619 T618 arg1Of BMDC,mutant
R535 T619 T621 arg1Of BMDC,induced
R536 T619 T628 arg1Of BMDC,stimulated
R537 T621 T627 arg1Of induced,but
R538 T626 T621 arg2Of response,induced
R539 T626 T622 arg1Of response,a
R540 T626 T623 arg1Of response,weak
R541 T626 T624 arg1Of response,Th1
R542 T626 T625 arg1Of response,immune
R543 T627 T616 arg2Of but,showed
R544 T627 T617 arg1Of but,that
R545 T627 T620 arg1Of but,only
R546 T628 T627 arg2Of stimulated,but
R547 T628 T633 arg1Of stimulated,from
R548 T632 T628 arg2Of production,stimulated
R549 T632 T629 arg2Of production,increased
R550 T632 T630 arg1Of production,Th2
R551 T632 T631 arg1Of production,cytokine
R552 T638 T633 arg2Of cells,from
R553 T638 T634 arg1Of cells,allogeneic
R554 T638 T635 arg1Of cells,naïve
R555 T638 T636 arg1Of cells,CD4+
R556 T638 T637 arg1Of cells,T
R557 T640 T639 arg2Of conclusion,In
R558 T642 T643 arg1Of loss,of
R559 T642 T645 arg1Of loss,in
R560 T642 T648 arg1Of loss,affects
R561 T644 T643 arg2Of Sharpin,of
R562 T646 T645 arg2Of mice,in
R563 T648 T647 arg1Of affects,significantly
R564 T648 T654 arg1Of affects,and
R565 T651 T648 arg2Of function,affects
R566 T651 T649 arg1Of function,the
R567 T651 T650 arg1Of function,immune
R568 T651 T652 arg1Of function,of
R569 T653 T652 arg2Of DC,of
R570 T654 T639 arg1Of and,In
R571 T654 T641 arg1Of and,","
R572 T655 T656 arg1Of this,may
R573 T655 T658 arg1Of this,account
R574 T658 T654 arg2Of account,and
R575 T658 T656 arg2Of account,may
R576 T658 T657 arg1Of account,partially
R577 T658 T659 arg1Of account,for
R578 T662 T661 arg1Of inflammation,systemic
R579 T662 T663 arg1Of inflammation,and
R580 T663 T659 arg2Of and,for
R581 T663 T660 arg1Of and,the
R582 T666 T663 arg2Of response,and
R583 T666 T664 arg1Of response,Th2-biased
R584 T666 T665 arg1Of response,immune
R6548 T7944 T7942 arg1Of report,The
R6549 T7944 T7943 arg1Of report,present
R6550 T7944 T7945 arg1Of report,showed
R6551 T7948 T7947 arg1Of mutations,null
R6552 T7948 T7949 arg1Of mutations,of
R6553 T7948 T7954 arg1Of mutations,did
R6554 T7948 T7956 arg1Of mutations,affect
R6555 T7953 T7949 arg2Of gene,of
R6556 T7953 T7950 arg1Of gene,the
R6557 T7953 T7951 arg1Of gene,mouse
R6558 T7953 T7952 arg1Of gene,Sharpin
R6559 T7956 T7945 arg2Of affect,showed
R6560 T7956 T7946 arg1Of affect,that
R6561 T7956 T7954 arg2Of affect,did
R6562 T7956 T7955 arg1Of affect,not
R6563 T7959 T7957 arg1Of distribution,the
R6564 T7959 T7958 arg1Of distribution,steady-state
R6565 T7959 T7960 arg1Of distribution,of
R6566 T7959 T7964 arg1Of distribution,nor
R6567 T7963 T7960 arg2Of subsets,of
R6568 T7963 T7961 arg1Of subsets,splenic
R6569 T7963 T7962 arg1Of subsets,DC
R6570 T7964 T7956 arg2Of nor,affect
R6571 T7966 T7967 arg1Of development,and
R6572 T7967 T7964 arg2Of and,nor
R6573 T7967 T7965 arg1Of and,the
R6574 T7967 T7969 arg1Of and,of
R6575 T7968 T7967 arg2Of phenotype,and
R6576 T7970 T7969 arg2Of BMDC,of
R6577 T7973 T7974 arg1Of loss,of
R6578 T7973 T7977 arg1Of loss,diminished
R6579 T7975 T7974 arg2Of SHARPIN,of
R6580 T7977 T7971 arg1Of diminished,However
R6581 T7977 T7972 arg1Of diminished,","
R6582 T7977 T7976 arg1Of diminished,significantly
R6583 T7979 T7977 arg2Of capacity,diminished
R6584 T7979 T7978 arg1Of capacity,the
R6585 T7979 T7980 arg1Of capacity,of
R6586 T7979 T7982 modOf capacity,to
R6587 T7981 T7980 arg2Of BMDC,of
R6588 T7983 T7982 arg1Of secrete,to
R6589 T7985 T7984 arg1Of cytokines,inflammatory
R6590 T7985 T7986 arg1Of cytokines,and
R6591 T7986 T7983 arg2Of and,secrete
R6592 T7988 T7986 arg2Of oxide,and
R6593 T7988 T7987 arg1Of oxide,nitric
R6594 T7992 T7989 arg1Of production,The
R6595 T7992 T7990 arg2Of production,attenuated
R6596 T7992 T7991 arg1Of production,cytokine
R6597 T7992 T7993 arg1Of production,was
R6598 T7992 T7995 arg1Of production,due
R6599 T7992 T8004 arg1Of production,can
R6600 T7992 T8005 arg1Of production,be
R6601 T7992 T8007 arg2Of production,explained
R6602 T7993 T7994 arg1Of was,not
R6603 T7993 T8003 arg1Of was,and
R6604 T7995 T7993 arg2Of due,was
R6605 T7995 T7996 arg1Of due,to
R6606 T7998 T7996 arg2Of presence,to
R6607 T7998 T7997 arg1Of presence,the
R6608 T7998 T7999 arg1Of presence,of
R6609 T8001 T7999 arg2Of inhibitors,of
R6610 T8001 T8000 arg1Of inhibitors,anti-inflammatory
R6611 T8003 T8002 arg1Of and,","
R6612 T8007 T8003 arg2Of explained,and
R6613 T8007 T8004 arg2Of explained,can
R6614 T8007 T8005 arg2Of explained,be
R6615 T8007 T8006 arg1Of explained,largely
R6616 T8007 T8008 arg1Of explained,by
R6617 T8010 T8008 arg2Of inactivation,by
R6618 T8010 T8009 arg1Of inactivation,selective
R6619 T8010 T8011 arg1Of inactivation,of
R6620 T8013 T8011 arg2Of signaling,of
R6621 T8013 T8012 arg1Of signaling,NF-κB
R6622 T8016 T8014 arg2Of BMDC,Stimulated
R6623 T8016 T8015 arg1Of BMDC,cpdm
R6624 T8016 T8017 arg1Of BMDC,exhibited
R6625 T8017 T8022 arg1Of exhibited,","
R6626 T8017 T8023 arg1Of exhibited,consistent
R6627 T8021 T8017 arg2Of capabilities,exhibited
R6628 T8021 T8018 arg1Of capabilities,Th2-biased
R6629 T8021 T8019 arg1Of capabilities,T
R6630 T8021 T8020 arg1Of capabilities,cell-polarizing
R6631 T8023 T8024 arg1Of consistent,with
R6632 T8028 T8024 arg2Of phenotype,with
R6633 T8028 T8025 arg1Of phenotype,the
R6634 T8028 T8026 arg1Of phenotype,Th2
R6635 T8028 T8027 arg1Of phenotype,cytokine-dominant
R6636 T8028 T8029 arg1Of phenotype,in
R6637 T8031 T8029 arg2Of mice,in
R6638 T8031 T8030 arg1Of mice,cpdm
R6639 T8035 T8034 arg1Of results,these
R6640 T8035 T8036 arg1Of results,indicate
R6641 T8036 T8032 arg1Of indicate,Together
R6642 T8036 T8033 arg1Of indicate,","
R6643 T8039 T8036 arg2Of role,indicate
R6644 T8039 T8037 arg1Of role,an
R6645 T8039 T8038 arg1Of role,indispensible
R6646 T8039 T8040 arg1Of role,of
R6647 T8041 T8040 arg2Of SHARPIN,of
R6648 T8041 T8042 arg1Of SHARPIN,in
R6649 T8043 T8042 arg2Of regulating,in
R6650 T8046 T8043 arg2Of functions,regulating
R6651 T8046 T8044 arg1Of functions,DC
R6652 T8046 T8045 arg1Of functions,immunological
R6653 T8046 T8049 arg2Of functions,of
R6654 T8046 T8050 arg1Of functions,which
R6655 T8048 T8049 arg1Of disruption,of
R6656 T8048 T8051 arg1Of disruption,may
R6657 T8048 T8052 arg1Of disruption,contribute
R6658 T8052 T8047 arg1Of contribute,","
R6659 T8052 T8051 arg2Of contribute,may
R6660 T8052 T8053 arg1Of contribute,to
R6661 T8055 T8053 arg2Of development,to
R6662 T8055 T8054 arg1Of development,the
R6663 T8055 T8056 arg1Of development,of
R6664 T8058 T8056 arg2Of diseases,of
R6665 T8058 T8057 arg1Of diseases,immune
R6666 T8060 T8061 arg1Of WT,and
R6667 T8062 T8061 arg2Of cpdm,and
R6668 T8063 T8060 arg1Of mice,WT
R6669 T8063 T8062 arg1Of mice,cpdm
R6670 T8063 T8064 arg1Of mice,are
R6671 T8064 T8059 arg2Of are,Since
R6672 T8067 T8064 arg2Of pathogen-free,are
R6673 T8067 T8065 arg1Of pathogen-free,both
R6674 T8067 T8066 arg1Of pathogen-free,specific
R6675 T8070 T8069 arg1Of nature,the
R6676 T8070 T8071 arg1Of nature,of
R6677 T8070 T8081 arg1Of nature,is
R6678 T8070 T8083 arg1Of nature,obvious
R6679 T8073 T8071 arg2Of trigger,of
R6680 T8073 T8072 arg1Of trigger,the
R6681 T8073 T8074 arg1Of trigger,of
R6682 T8073 T8078 arg1Of trigger,in
R6683 T8077 T8074 arg2Of inflammation,of
R6684 T8077 T8075 arg1Of inflammation,the
R6685 T8077 T8076 arg1Of inflammation,severe
R6686 T8080 T8078 arg2Of mice,in
R6687 T8080 T8079 arg1Of mice,cpdm
R6688 T8081 T8059 arg1Of is,Since
R6689 T8081 T8068 arg1Of is,","
R6690 T8081 T8082 arg1Of is,not
R6691 T8083 T8081 arg2Of obvious,is
R6692 T8087 T8084 arg1Of factor,One
R6693 T8087 T8085 arg1Of factor,such
R6694 T8087 T8086 arg1Of factor,initiating
R6695 T8087 T8088 arg1Of factor,could
R6696 T8087 T8089 arg1Of factor,be
R6697 T8089 T8088 arg2Of be,could
R6698 T8091 T8092 arg1Of apoptotic,and/or
R6699 T8093 T8092 arg2Of necrotic,and/or
R6700 T8094 T8089 arg2Of cells,be
R6701 T8094 T8090 arg1Of cells,endogenous
R6702 T8094 T8091 arg1Of cells,apoptotic
R6703 T8094 T8093 arg1Of cells,necrotic
R6704 T8094 T8095 arg1Of cells,that
R6705 T8094 T8096 arg1Of cells,can
R6706 T8094 T8097 arg1Of cells,release
R6707 T8097 T8096 arg2Of release,can
R6708 T8100 T8097 arg2Of patterns,release
R6709 T8100 T8098 arg1Of patterns,danger-associated
R6710 T8100 T8099 arg1Of patterns,molecular
R6711 T8100 T8101 arg1Of patterns,(
R6712 T8100 T8105 arg1Of patterns,launch
R6713 T8100 T8107 arg1Of patterns,amplify
R6714 T8102 T8101 arg2Of DAMPs,(
R6715 T8103 T8101 arg3Of ),(
R6716 T8105 T8106 arg1Of launch,and
R6717 T8106 T8097 arg3Of and,release
R6718 T8106 T8104 arg1Of and,to
R6719 T8106 T8111 arg1Of and,[
R6720 T8107 T8106 arg2Of amplify,and
R6721 T8110 T8105 arg2Of response,launch
R6722 T8110 T8107 arg2Of response,amplify
R6723 T8110 T8108 arg1Of response,an
R6724 T8110 T8109 arg1Of response,inflammatory
R6725 T8112 T8111 arg2Of 32,[
R6726 T8113 T8111 arg3Of ],[
R6727 T8116 T8114 arg1Of inflammation,Such
R6728 T8116 T8115 arg1Of inflammation,‘sterile’
R6729 T8116 T8117 arg1Of inflammation,could
R6730 T8116 T8118 arg1Of inflammation,be
R6731 T8116 T8119 arg2Of inflammation,initiated
R6732 T8116 T8121 arg1Of inflammation,take
R6733 T8119 T8118 arg2Of initiated,be
R6734 T8119 T8120 arg1Of initiated,and
R6735 T8120 T8117 arg2Of and,could
R6736 T8120 T8132 arg1Of and,","
R6737 T8120 T8134 modOf and,causing
R6738 T8121 T8120 arg2Of take,and
R6739 T8121 T8123 arg1Of take,in
R6740 T8122 T8121 arg2Of place,take
R6741 T8125 T8126 arg1Of organs,and
R6742 T8126 T8123 arg2Of and,in
R6743 T8126 T8124 arg1Of and,all
R6744 T8126 T8128 arg2Of and,affected
R6745 T8127 T8126 arg2Of tissues,and
R6746 T8128 T8129 arg1Of affected,in
R6747 T8131 T8129 arg2Of mice,in
R6748 T8131 T8130 arg1Of mice,cpdm
R6749 T8134 T8133 arg1Of causing,thus
R6750 T8137 T8134 arg2Of disorders,causing
R6751 T8137 T8135 arg1Of disorders,multi-organ
R6752 T8137 T8136 arg1Of disorders,inflammatory
R6753 T8139 T8138 arg1Of hypothesis,This
R6754 T8139 T8140 arg1Of hypothesis,is
R6755 T8139 T8141 arg2Of hypothesis,supported
R6756 T8141 T8140 arg2Of supported,is
R6757 T8145 T8141 arg1Of studies,supported
R6758 T8145 T8142 arg2Of studies,by
R6759 T8145 T8143 arg1Of studies,several
R6760 T8145 T8144 arg1Of studies,recent
R6761 T8146 T8147 arg1Of Fibroblasts,of
R6762 T8146 T8150 arg1Of Fibroblasts,are
R6763 T8146 T8152 arg1Of Fibroblasts,sensitive
R6764 T8149 T8147 arg2Of mice,of
R6765 T8149 T8148 arg1Of mice,cpdm
R6766 T8150 T8157 arg1Of are,and
R6767 T8152 T8150 arg2Of sensitive,are
R6768 T8152 T8151 arg1Of sensitive,highly
R6769 T8152 T8153 arg1Of sensitive,to
R6770 T8156 T8153 arg2Of death,to
R6771 T8156 T8154 arg1Of death,TNFα-induced
R6772 T8156 T8155 arg1Of death,cell
R6773 T8160 T8158 arg1Of phenotype,the
R6774 T8160 T8159 arg1Of phenotype,cpdm
R6775 T8160 T8161 arg1Of phenotype,can
R6776 T8160 T8162 arg1Of phenotype,be
R6777 T8160 T8164 arg2Of phenotype,rescued
R6778 T8164 T8157 arg2Of rescued,and
R6779 T8164 T8161 arg2Of rescued,can
R6780 T8164 T8162 arg2Of rescued,be
R6781 T8164 T8163 arg1Of rescued,partially
R6782 T8164 T8172 arg1Of rescued,","
R6783 T8164 T8173 arg1Of rescued,[
R6784 T8164 T8176 arg1Of rescued,","
R6785 T8164 T8177 modOf rescued,suggesting
R6786 T8166 T8164 arg1Of deletion,rescued
R6787 T8166 T8165 arg2Of deletion,by
R6788 T8166 T8167 arg1Of deletion,of
R6789 T8168 T8167 arg2Of TNF,of
R6790 T8168 T8169 arg1Of TNF,[
R6791 T8170 T8169 arg2Of 7,[
R6792 T8171 T8169 arg3Of ],[
R6793 T8174 T8173 arg2Of 8,[
R6794 T8175 T8173 arg3Of ],[
R6795 T8179 T8180 arg1Of deficiency,of
R6796 T8179 T8182 arg1Of deficiency,compromises
R6797 T8181 T8180 arg2Of SHARPIN,of
R6798 T8182 T8177 arg2Of compromises,suggesting
R6799 T8182 T8178 arg1Of compromises,that
R6800 T8182 T8186 arg1Of compromises,in
R6801 T8185 T8182 arg2Of mechanisms,compromises
R6802 T8185 T8183 arg1Of mechanisms,the
R6803 T8185 T8184 arg1Of mechanisms,anti-apoptotic
R6804 T8188 T8186 arg2Of mice,in
R6805 T8188 T8187 arg1Of mice,cpdm
R6806 T8188 T8189 arg1Of mice,resulting
R6807 T8189 T8190 arg1Of resulting,in
R6808 T8194 T8190 arg2Of disease,in
R6809 T8194 T8191 arg1Of disease,cell
R6810 T8194 T8192 arg1Of disease,death-induced
R6811 T8194 T8193 arg1Of disease,inflammatory
R6812 T8195 T8196 arg1Of Apoptosis,of
R6813 T8195 T8198 arg1Of Apoptosis,is
R6814 T8197 T8196 arg2Of keratinocytes,of
R6815 T8198 T8209 arg1Of is,[
R6816 T8198 T8212 arg1Of is,and
R6817 T8201 T8198 arg2Of feature,is
R6818 T8201 T8199 arg1Of feature,a
R6819 T8201 T8200 arg1Of feature,prominent
R6820 T8201 T8202 arg1Of feature,of
R6821 T8201 T8206 arg1Of feature,in
R6822 T8205 T8202 arg2Of lesions,of
R6823 T8205 T8203 arg1Of lesions,the
R6824 T8205 T8204 arg1Of lesions,skin
R6825 T8208 T8206 arg2Of mice,in
R6826 T8208 T8207 arg1Of mice,cpdm
R6827 T8210 T8209 arg2Of 33,[
R6828 T8211 T8209 arg3Of ],[
R6829 T8212 T8220 arg1Of and,[
R6830 T8213 T8214 arg1Of this,is
R6831 T8213 T8215 arg2Of this,mediated
R6832 T8215 T8212 arg2Of mediated,and
R6833 T8215 T8214 arg2Of mediated,is
R6834 T8219 T8215 arg1Of pathways,mediated
R6835 T8219 T8216 arg2Of pathways,by
R6836 T8219 T8217 arg1Of pathways,caspase-dependent
R6837 T8219 T8218 arg1Of pathways,mitochondrial
R6838 T8221 T8220 arg2Of 34,[
R6839 T8222 T8220 arg3Of ],[
R6840 T8322 T8319 arg1Of inflammation,the
R6841 T8224 T8225 arg1Of induced,and/or
R6842 T8226 T8225 arg2Of intrinsic,and/or
R6843 T8228 T8223 arg1Of cells,These
R6844 T8228 T8224 arg1Of cells,induced
R6845 T8228 T8226 arg1Of cells,intrinsic
R6846 T8228 T8227 arg1Of cells,apoptotic
R6847 T8228 T8229 arg1Of cells,can
R6848 T8228 T8230 arg1Of cells,release
R6849 T8230 T8229 arg2Of release,can
R6850 T8230 T8264 arg1Of release,","
R6851 T8230 T8265 arg1Of release,[
R6852 T8322 T8320 arg1Of inflammation,Th2-biased
R6853 T8232 T8230 arg2Of types,release
R6854 T8232 T8231 arg1Of types,various
R6855 T8232 T8233 arg1Of types,of
R6856 T8322 T8321 arg1Of inflammation,systemic
R6857 T8234 T8233 arg2Of DAMPs,of
R6858 T8234 T8235 arg1Of DAMPs,that
R6859 T8234 T8236 arg1Of DAMPs,exert
R6860 T8234 T8241 arg1Of DAMPs,activating
R6861 T8234 T8254 arg1Of DAMPs,","
R6862 T8234 T8256 arg1Of DAMPs,as
R6863 T8322 T8323 arg1Of inflammation,in
R6864 T8236 T8240 arg1Of exert,by
R6865 T8236 T8250 arg1Of exert,","
R6866 T8236 T8251 arg1Of exert,[
R6867 T8322 T8326 arg1Of inflammation,is
R6868 T8322 T8327 arg2Of inflammation,caused
R6869 T8239 T8236 arg2Of properties,exert
R6870 T8239 T8237 arg1Of properties,their
R6871 T8239 T8238 arg1Of properties,pro-inflammatory
R6872 T8325 T8323 arg2Of mice,in
R6873 T8241 T8240 arg2Of activating,by
R6874 T8241 T8243 arg1Of activating,through
R6875 T8242 T8241 arg2Of DC,activating
R6876 T8325 T8324 arg1Of mice,cpdm
R6877 T8246 T8243 arg2Of receptors,through
R6878 T8246 T8244 arg1Of receptors,pattern
R6879 T8246 T8245 arg1Of receptors,recognition
R6880 T8246 T8247 arg1Of receptors,[
R6881 T8248 T8247 arg2Of 32,[
R6882 T8327 T8317 arg2Of caused,suggests
R6883 T8249 T8247 arg3Of ],[
R6884 T8252 T8251 arg2Of 35,[
R6885 T8327 T8318 arg1Of caused,that
R6886 T8253 T8251 arg3Of ],[
R6887 T8327 T8326 arg2Of caused,is
R6888 T8331 T8327 arg1Of production,caused
R6889 T8256 T8255 arg1Of as,such
R6890 T8257 T8256 arg2Of HMGB1,as
R6891 T8257 T8258 arg2Of HMGB1,recognized
R6892 T8260 T8258 arg1Of TLR2/4,recognized
R6893 T8260 T8259 arg2Of TLR2/4,by
R6894 T8260 T8261 arg1Of TLR2/4,[
R6895 T8262 T8261 arg2Of 36,[
R6896 T8331 T8328 arg2Of production,by
R6897 T8263 T8261 arg3Of ],[
R6898 T8266 T8265 arg2Of 37,[
R6899 T8331 T8329 arg2Of production,reduced
R6900 T8267 T8265 arg3Of ],[
R6901 T8268 T8269 arg1Of Consistent,with
R6902 T8331 T8330 arg1Of production,IL12P70
R6903 T8331 T8332 arg1Of production,from
R6904 T8333 T8332 arg2Of DC,from
R6905 T8274 T8269 arg2Of response,with
R6906 T8274 T8270 arg1Of response,the
R6907 T8274 T8271 arg1Of response,impaired
R6908 T8274 T8272 arg1Of response,Th1
R6909 T8274 T8273 arg1Of response,immune
R6910 T8274 T8275 arg1Of response,in
R6911 T8335 T8334 arg1Of importance,The
R6912 T8277 T8275 arg2Of mice,in
R6913 T8277 T8276 arg1Of mice,cpdm
R6914 T8277 T8278 arg1Of mice,[
R6915 T8279 T8278 arg2Of 5,[
R6916 T8280 T8278 arg3Of ],[
R6917 T8335 T8336 arg1Of importance,of
R6918 T8335 T8338 arg1Of importance,in
R6919 T8335 T8345 arg1Of importance,in
R6920 T8283 T8282 arg1Of BMDC,stimulated
R6921 T8283 T8285 arg1Of BMDC,polarized
R6922 T8283 T8291 arg1Of BMDC,supported
R6923 T8335 T8347 arg1Of importance,was
R6924 T8285 T8289 arg1Of polarized,but
R6925 T8335 T8349 arg2Of importance,demonstrated
R6926 T8337 T8336 arg2Of IL12P70,of
R6927 T8287 T8285 arg2Of differentiation,polarized
R6928 T8287 T8286 arg1Of differentiation,Th1
R6929 T8289 T8268 arg1Of but,Consistent
R6930 T8289 T8281 arg1Of but,","
R6931 T8289 T8284 arg1Of but,weakly
R6932 T8289 T8288 arg1Of but,","
R6933 T8291 T8289 arg2Of supported,but
R6934 T8291 T8290 arg1Of supported,strongly
R6935 T8339 T8338 arg2Of regulating,in
R6936 T8293 T8291 arg2Of development,supported
R6937 T8293 T8292 arg1Of development,the
R6938 T8293 T8294 arg1Of development,of
R6939 T8297 T8294 arg2Of cells,of
R6940 T8297 T8295 arg1Of cells,Th2
R6941 T8297 T8296 arg1Of cells,effector
R6942 T8298 T8299 arg1Of Combined,with
R6943 T8340 T8341 arg1Of Th1,and
R6944 T8342 T8341 arg2Of Th2,and
R6945 T8302 T8299 arg2Of effect,with
R6946 T8302 T8300 arg1Of effect,the
R6947 T8302 T8301 arg1Of effect,dramatic
R6948 T8302 T8303 arg1Of effect,of
R6949 T8302 T8306 arg1Of effect,on
R6950 T8305 T8303 arg2Of treatment,of
R6951 T8305 T8304 arg1Of treatment,IL12
R6952 T8308 T8306 arg2Of phenotype,on
R6953 T8308 T8307 arg1Of phenotype,the
R6954 T8308 T8309 arg1Of phenotype,of
R6955 T8344 T8339 arg2Of responses,regulating
R6956 T8311 T8309 arg2Of mice,of
R6957 T8311 T8310 arg1Of mice,these
R6958 T8311 T8312 arg1Of mice,[
R6959 T8313 T8312 arg2Of 5,[
R6960 T8314 T8312 arg3Of ],[
R6961 T8344 T8340 arg1Of responses,Th1
R6962 T8316 T8298 arg2Of this,Combined
R6963 T8316 T8317 arg1Of this,suggests
R6964 T8344 T8342 arg1Of responses,Th2
R6965 T8317 T8298 modOf suggests,Combined
R6966 T8317 T8315 arg1Of suggests,","
R6967 T8344 T8343 arg1Of responses,immune
R6968 T8346 T8345 arg2Of mice,in
R6969 T8349 T8347 arg2Of demonstrated,was
R6970 T8416 T8405 arg1Of C,NF-κB
R6971 T8416 T8417 arg1Of C,stimulated
R6972 T8349 T8348 arg1Of demonstrated,clearly
R6973 T8417 T8420 arg1Of stimulated,compared
R6974 T8349 T8350 arg1Of demonstrated,in
R6975 T8417 T8424 arg1Of stimulated,","
R6976 T8417 T8425 arg1Of stimulated,while
R6977 T8349 T8363 arg1Of demonstrated,through
R6978 T8419 T8417 arg2Of BMDC,stimulated
R6979 T8419 T8418 arg1Of BMDC,cpdm
R6980 T8349 T8369 arg1Of demonstrated,[
R6981 T8421 T8420 arg2Of to,compared
R6982 T8349 T8372 arg1Of demonstrated,–
R6983 T8349 T8373 arg1Of demonstrated,[
R6984 T8423 T8421 arg2Of type,to
R6985 T8423 T8422 arg1Of type,wild
R6986 T8350 T8362 arg1Of in,and
R6987 T8426 T8427 arg1Of activation,of
R6988 T8426 T8434 arg1Of activation,was
R6989 T8426 T8437 arg1Of activation,indicating
R6990 T8351 T8352 arg1Of IL12P35-,and
R6991 T8428 T8429 arg1Of TBK1/IRF3,","
R6992 T8429 T8432 arg1Of ",",or
R6993 T8430 T8429 arg2Of ERK1/2,","
R6994 T8353 T8352 arg2Of IL12P40-deficient,and
R6995 T8432 T8427 arg2Of or,of
R6996 T8432 T8431 arg1Of or,","
R6997 T8433 T8432 arg2Of p38,or
R6998 T8437 T8425 arg2Of indicating,while
R6999 T8437 T8434 arg2Of indicating,was
R7000 T8437 T8435 arg1Of indicating,not
R7001 T8437 T8436 arg1Of indicating,","
R7002 T8354 T8350 arg2Of mice,in
R7003 T8441 T8439 arg2Of signaling,disrupted
R7004 T8441 T8440 arg1Of signaling,NF-κB
R7005 T8441 T8442 arg1Of signaling,in
R7006 T8441 T8445 arg1Of signaling,is
R7007 T8441 T8446 arg1Of signaling,responsible
R7008 T8354 T8351 arg1Of mice,IL12P35-
R7009 T8444 T8442 arg2Of DC,in
R7010 T8444 T8443 arg1Of DC,cpdm
R7011 T8445 T8437 arg2Of is,indicating
R7012 T8445 T8438 arg1Of is,that
R7013 T8354 T8353 arg1Of mice,IL12P40-deficient
R7014 T8446 T8445 arg2Of responsible,is
R7015 T8446 T8447 arg1Of responsible,for
R7016 T8354 T8355 arg1Of mice,[
R7017 T8354 T8358 arg1Of mice,","
R7018 T8354 T8359 arg1Of mice,[
R7019 T8356 T8355 arg2Of 38,[
R7020 T8451 T8447 arg2Of expression,for
R7021 T8451 T8448 arg1Of expression,the
R7022 T8451 T8449 arg1Of expression,defective
R7023 T8451 T8450 arg1Of expression,cytokine
R7024 T8453 T8452 arg1Of results,These
R7025 T8453 T8454 arg1Of results,seem
R7026 T8453 T8456 arg1Of results,contradict
R7027 T8357 T8355 arg3Of ],[
R7028 T8456 T8454 arg2Of contradict,seem
R7029 T8456 T8455 arg1Of contradict,to
R7030 T8360 T8359 arg2Of 39,[
R7031 T8459 T8456 arg2Of study,contradict
R7032 T8459 T8457 arg1Of study,a
R7033 T8459 T8458 arg1Of study,recent
R7034 T8459 T8460 arg1Of study,that
R7035 T8459 T8461 arg1Of study,found
R7036 T8461 T8473 arg1Of found,[
R7037 T8361 T8359 arg3Of ],[
R7038 T8463 T8461 arg2Of levels,found
R7039 T8463 T8462 arg2Of levels,increased
R7040 T8463 T8464 arg1Of levels,of
R7041 T8363 T8362 arg2Of through,and
R7042 T8466 T8465 arg1Of activation,NF-κB
R7043 T8466 T8467 arg1Of activation,and
R7044 T8467 T8464 arg2Of and,of
R7045 T8467 T8470 arg1Of and,in
R7046 T8469 T8467 arg2Of transcription,and
R7047 T8469 T8468 arg1Of transcription,IL1
R7048 T8365 T8363 arg2Of studies,through
R7049 T8472 T8470 arg2Of mice,in
R7050 T8472 T8471 arg1Of mice,cpdm
R7051 T8474 T8473 arg2Of 43,[
R7052 T8475 T8473 arg3Of ],[
R7053 T8477 T8476 arg1Of difference,This
R7054 T8477 T8478 arg1Of difference,can
R7055 T8477 T8480 arg1Of difference,be
R7056 T8477 T8481 arg2Of difference,attributed
R7057 T8477 T8494 arg1Of difference,may
R7058 T8477 T8495 arg1Of difference,point
R7059 T8365 T8364 arg1Of studies,clinical
R7060 T8365 T8366 arg1Of studies,in
R7061 T8481 T8478 arg2Of attributed,can
R7062 T8481 T8479 arg1Of attributed,probably
R7063 T8481 T8480 arg2Of attributed,be
R7064 T8481 T8482 arg1Of attributed,to
R7065 T8481 T8493 arg1Of attributed,and
R7066 T8368 T8366 arg2Of patients,in
R7067 T8485 T8486 arg1Of cells,and
R7068 T8486 T8482 arg2Of and,to
R7069 T8486 T8483 arg1Of and,the
R7070 T8486 T8484 arg1Of and,different
R7071 T8486 T8488 arg2Of and,used
R7072 T8487 T8486 arg2Of tissues,and
R7073 T8488 T8489 arg1Of used,in
R7074 T8368 T8367 arg1Of patients,human
R7075 T8370 T8369 arg2Of 40,[
R7076 T8491 T8489 arg2Of studies,in
R7077 T8491 T8490 arg1Of studies,these
R7078 T8493 T8492 arg1Of and,","
R7079 T8371 T8369 arg3Of ],[
R7080 T8495 T8493 arg2Of point,and
R7081 T8495 T8494 arg2Of point,may
R7082 T8495 T8496 arg1Of point,to
R7083 T8374 T8373 arg2Of 42,[
R7084 T8497 T8498 arg1Of cell-,and
R7085 T8499 T8498 arg2Of tissue-,and
R7086 T8375 T8373 arg3Of ],[
R7087 T8502 T8496 arg2Of functions,to
R7088 T8502 T8497 arg1Of functions,cell-
R7089 T8502 T8499 arg1Of functions,tissue-
R7090 T8502 T8500 arg1Of functions,type
R7091 T8502 T8501 arg1Of functions,specific
R7092 T8502 T8503 arg1Of functions,of
R7093 T8504 T8503 arg2Of SHARPIN,of
R7094 T8505 T8506 arg1Of This,is
R7095 T8505 T8507 arg1Of This,consistent
R7096 T8376 T8377 arg1Of NF-κB,","
R7097 T8377 T8380 arg1Of ",",and
R7098 T8506 T8517 arg1Of is,[
R7099 T8507 T8506 arg2Of consistent,is
R7100 T8507 T8508 arg1Of consistent,with
R7101 T8378 T8377 arg2Of TBK/IRF3,","
R7102 T8510 T8508 arg2Of reports,with
R7103 T8510 T8509 arg1Of reports,recent
R7104 T8510 T8511 arg1Of reports,of
R7105 T8380 T8379 arg1Of and,","
R7106 T8380 T8383 arg1Of and,are
R7107 T8382 T8380 arg2Of signaling,and
R7108 T8382 T8381 arg1Of signaling,MAPK
R7109 T8383 T8392 arg1Of are,:
R7110 T8513 T8511 arg2Of effects,of
R7111 T8513 T8512 arg1Of effects,tissue-specific
R7112 T8513 T8514 arg1Of effects,of
R7113 T8385 T8383 arg2Of pathways,are
R7114 T8516 T8514 arg2Of signaling,of
R7115 T8516 T8515 arg1Of signaling,NF-κB
R7116 T8518 T8517 arg2Of 44,[
R7117 T8519 T8517 arg3Of ],[
R7118 T8385 T8384 arg1Of pathways,important
R7119 T8385 T8386 arg2Of pathways,activated
R7120 T8521 T8520 arg1Of activation,Ubiquitous
R7121 T8521 T8522 arg1Of activation,of
R7122 T8521 T8524 arg1Of activation,by
R7123 T8521 T8535 arg1Of activation,results
R7124 T8521 T8540 arg1Of activation,consistent
R7125 T8388 T8389 arg1Of LPS,or
R7126 T8523 T8522 arg2Of NF-κB,of
R7127 T8525 T8524 arg2Of removing,by
R7128 T8526 T8525 arg2Of inhibitors,removing
R7129 T8526 T8528 arg1Of inhibitors,as
R7130 T8389 T8386 arg1Of or,activated
R7131 T8528 T8527 arg1Of as,such
R7132 T8529 T8530 arg1Of A20,and
R7133 T8530 T8528 arg2Of and,as
R7134 T8530 T8532 arg1Of and,through
R7135 T8389 T8387 arg2Of or,by
R7136 T8531 T8530 arg2Of ITCH,and
R7137 T8391 T8389 arg2Of I,or
R7138 T8534 T8532 arg2Of manipulation,through
R7139 T8534 T8533 arg1Of manipulation,genetic
R7140 T8535 T8536 arg1Of results,in
R7141 T8535 T8539 arg1Of results,","
R7142 T8535 T8540 modOf results,consistent
R7143 T8391 T8390 arg1Of I,poly
R7144 T8535 T8555 arg1Of results,","
R7145 T8535 T8556 arg1Of results,[
R7146 T8393 T8394 arg1Of C,and
R7147 T8538 T8536 arg2Of inflammation,in
R7148 T8538 T8537 arg1Of inflammation,widespread
R7149 T8540 T8541 arg1Of consistent,with
R7150 T8394 T8396 arg1Of and,of
R7151 T8543 T8541 arg2Of role,with
R7152 T8543 T8542 arg1Of role,the
R7153 T8543 T8544 arg1Of role,of
R7154 T8543 T8546 arg1Of role,in
R7155 T8545 T8544 arg2Of NF-κB,of
R7156 T8394 T8399 arg1Of and,may
R7157 T8394 T8400 arg1Of and,lead
R7158 T8548 T8546 arg2Of production,in
R7159 T8548 T8547 arg1Of production,the
R7160 T8548 T8549 arg1Of production,of
R7161 T8395 T8394 arg2Of disruption,and
R7162 T8551 T8549 arg2Of mediators,of
R7163 T8551 T8550 arg1Of mediators,pro-inflammatory
R7164 T8551 T8552 arg1Of mediators,[
R7165 T8398 T8396 arg2Of pathway,of
R7166 T8553 T8552 arg2Of 45,[
R7167 T8554 T8552 arg3Of ],[
R7168 T8398 T8397 arg1Of pathway,either
R7169 T8557 T8556 arg2Of 46,[
R7170 T8400 T8392 arg2Of lead,:
R7171 T8558 T8556 arg3Of ],[
R7172 T8400 T8399 arg2Of lead,may
R7173 T8400 T8401 arg1Of lead,to
R7174 T8562 T8561 arg1Of inhibition,selective
R7175 T8562 T8563 arg1Of inhibition,of
R7176 T8562 T8566 arg1Of inhibition,in
R7177 T8562 T8577 arg1Of inhibition,results
R7178 T8565 T8563 arg2Of activation,of
R7179 T8565 T8564 arg1Of activation,NF-κB
R7180 T8404 T8401 arg2Of expression,to
R7181 T8568 T8566 arg2Of cells,in
R7182 T8568 T8567 arg1Of cells,parenchymal
R7183 T8568 T8569 arg1Of cells,of
R7184 T8571 T8572 arg1Of skin,","
R7185 T8572 T8575 arg1Of ",",and
R7186 T8404 T8402 arg2Of expression,decreased
R7187 T8573 T8572 arg2Of liver,","
R7188 T8404 T8403 arg1Of expression,cytokine
R7189 T8575 T8569 arg2Of and,of
R7190 T8575 T8570 arg1Of and,the
R7191 T8575 T8574 arg1Of and,","
R7192 T8576 T8575 arg2Of intestine,and
R7193 T8405 T8407 modOf NF-κB,was
R7194 T8577 T8559 arg1Of results,However
R7195 T8577 T8560 arg1Of results,","
R7196 T8577 T8578 arg1Of results,in
R7197 T8577 T8590 arg1Of results,[
R7198 T8580 T8578 arg2Of inflammation,in
R7199 T8580 T8579 arg1Of inflammation,chronic
R7200 T8580 T8581 arg2Of inflammation,driven
R7201 T8580 T8589 arg1Of inflammation,–
R7202 T8581 T8586 arg1Of driven,[
R7203 T8405 T8415 arg1Of NF-κB,:
R7204 T8585 T8581 arg1Of leukocytes,driven
R7205 T8585 T8582 arg2Of leukocytes,by
R7206 T8585 T8583 arg1Of leukocytes,NF-κB
R7207 T8585 T8584 arg1Of leukocytes,competent
R7208 T8406 T8407 arg1Of activation,was
R7209 T8587 T8586 arg2Of 47,[
R7210 T8588 T8586 arg3Of ],[
R7211 T8406 T8409 arg2Of activation,inhibited
R7212 T8409 T8407 arg2Of inhibited,was
R7213 T8591 T8590 arg2Of 50,[
R7214 T8592 T8590 arg3Of ],[
R7215 T8593 T8594 arg1Of This,indicates
R7216 T8409 T8408 arg1Of inhibited,selectively
R7217 T8409 T8410 arg1Of inhibited,in
R7218 T8597 T8596 arg1Of balance,a
R7219 T8597 T8598 arg1Of balance,between
R7220 T8597 T8613 arg1Of balance,is
R7221 T8597 T8614 arg1Of balance,critical
R7222 T8411 T8412 arg1Of LPS,and
R7223 T8601 T8599 arg1Of role,the
R7224 T8601 T8600 arg1Of role,pro-inflammatory
R7225 T8601 T8602 arg1Of role,of
R7226 T8601 T8604 arg1Of role,in
R7227 T8601 T8606 arg1Of role,and
R7228 T8603 T8602 arg2Of NF-κB,of
R7229 T8412 T8410 arg2Of and,in
R7230 T8605 T8604 arg2Of leukocytes,in
R7231 T8606 T8598 arg2Of and,between
R7232 T8414 T8412 arg2Of I,and
R7233 T8609 T8606 arg2Of role,and
R7234 T8609 T8607 arg1Of role,the
R7235 T8609 T8608 arg1Of role,anti-inflammatory
R7236 T8609 T8610 arg1Of role,in
R7237 T8414 T8413 arg1Of I,poly
R7238 T8709 T8707 arg1Of pathway,The
R7239 T8709 T8708 arg1Of pathway,non-canonical
R7240 T8612 T8610 arg2Of cells,in
R7241 T8612 T8611 arg1Of cells,parenchymal
R7242 T8613 T8594 arg2Of is,indicates
R7243 T8613 T8595 arg1Of is,that
R7244 T8709 T8710 arg1Of pathway,(
R7245 T8614 T8613 arg2Of critical,is
R7246 T8614 T8615 arg1Of critical,in
R7247 T8709 T8717 arg1Of pathway,appears
R7248 T8709 T8719 arg1Of pathway,be
R7249 T8617 T8615 arg2Of maintenance,in
R7250 T8617 T8616 arg1Of maintenance,the
R7251 T8617 T8618 arg1Of maintenance,of
R7252 T8709 T8720 arg1Of pathway,intact
R7253 T8712 T8710 arg2Of processing,(
R7254 T8620 T8618 arg2Of homeostasis,of
R7255 T8620 T8619 arg1Of homeostasis,tissue
R7256 T8621 T8622 arg1Of Experiments,with
R7257 T8621 T8636 arg1Of Experiments,will
R7258 T8621 T8637 arg1Of Experiments,help
R7259 T8621 T8639 arg1Of Experiments,elucidate
R7260 T8623 T8622 arg2Of mice,with
R7261 T8623 T8624 arg1Of mice,with
R7262 T8625 T8626 arg1Of cell-,and
R7263 T8712 T8711 arg1Of processing,p100
R7264 T8627 T8626 arg2Of tissue-specific,and
R7265 T8712 T8713 modOf processing,to
R7266 T8628 T8624 arg2Of deletion,with
R7267 T8628 T8625 arg1Of deletion,cell-
R7268 T8628 T8627 arg1Of deletion,tissue-specific
R7269 T8628 T8629 arg1Of deletion,of
R7270 T8714 T8713 arg1Of produce,to
R7271 T8630 T8629 arg2Of Sharpin,of
R7272 T8630 T8631 arg1Of Sharpin,","
R7273 T8630 T8633 arg1Of Sharpin,under
R7274 T8633 T8632 arg1Of under,currently
R7275 T8715 T8714 arg2Of p52,produce
R7276 T8634 T8633 arg2Of way,under
R7277 T8716 T8710 arg3Of ),(
R7278 T8637 T8635 arg1Of help,","
R7279 T8637 T8636 arg2Of help,will
R7280 T8639 T8637 arg2Of elucidate,help
R7281 T8639 T8638 arg1Of elucidate,to
R7282 T8719 T8717 arg2Of be,appears
R7283 T8641 T8639 arg2Of role,elucidate
R7284 T8641 T8640 arg1Of role,the
R7285 T8641 T8642 arg1Of role,of
R7286 T8641 T8644 arg1Of role,in
R7287 T8643 T8642 arg2Of SHARPIN,of
R7288 T8645 T8644 arg2Of inflammation,in
R7289 T8719 T8718 arg1Of be,to
R7290 T8719 T8731 modOf be,suggesting
R7291 T8720 T8719 arg2Of intact,be
R7292 T8649 T8646 arg2Of activation,Despite
R7293 T8649 T8647 arg1Of activation,defective
R7294 T8649 T8648 arg1Of activation,NF-κB
R7295 T8649 T8650 arg1Of activation,in
R7296 T8650 T8651 arg1Of in,the
R7297 T8650 T8653 arg1Of in,of
R7298 T8652 T8650 arg2Of absence,in
R7299 T8720 T8721 arg1Of intact,in
R7300 T8655 T8650 arg3Of expression,in
R7301 T8655 T8654 arg1Of expression,Sharpin
R7302 T8723 T8721 arg2Of cells,in
R7303 T8657 T8658 arg1Of there,was
R7304 T8658 T8646 arg1Of was,Despite
R7305 T8658 T8656 arg1Of was,","
R7306 T8658 T8662 arg1Of was,in
R7307 T8661 T8658 arg2Of change,was
R7308 T8661 T8659 arg1Of change,no
R7309 T8661 T8660 arg1Of change,significant
R7310 T8723 T8722 arg1Of cells,SHARPIN-deficient
R7311 T8723 T8724 arg1Of cells,[
R7312 T8665 T8663 arg1Of populations,splenic
R7313 T8665 T8664 arg1Of populations,DC
R7314 T8665 T8666 arg1Of populations,or
R7315 T8666 T8662 arg2Of or,in
R7316 T8723 T8727 arg1Of cells,","
R7317 T8667 T8666 arg2Of expression,or
R7318 T8667 T8668 arg1Of expression,of
R7319 T8667 T8671 arg1Of expression,on
R7320 T8723 T8728 arg1Of cells,[
R7321 T8725 T8724 arg2Of 7,[
R7322 T8670 T8668 arg2Of molecules,of
R7323 T8670 T8669 arg1Of molecules,co-stimulatory
R7324 T8672 T8671 arg2Of BMDC,on
R7325 T8726 T8724 arg3Of ],[
R7326 T8675 T8673 arg1Of subunits,Different
R7327 T8675 T8674 arg1Of subunits,NF-κB
R7328 T8675 T8676 arg2Of subunits,involved
R7329 T8675 T8688 arg1Of subunits,have
R7330 T8675 T8692 arg1Of subunits,control
R7331 T8729 T8728 arg2Of 9,[
R7332 T8676 T8677 arg1Of involved,in
R7333 T8679 T8680 arg1Of canonical,and
R7334 T8730 T8728 arg3Of ],[
R7335 T8681 T8680 arg2Of non-canonical,and
R7336 T8682 T8677 arg2Of branches,in
R7337 T8682 T8678 arg1Of branches,the
R7338 T8682 T8679 arg1Of branches,canonical
R7339 T8682 T8681 arg1Of branches,non-canonical
R7340 T8682 T8683 arg1Of branches,of
R7341 T8736 T8733 arg1Of p52/RELB,the
R7342 T8687 T8683 arg2Of pathway,of
R7343 T8687 T8684 arg1Of pathway,the
R7344 T8687 T8685 arg1Of pathway,NF-κB
R7345 T8687 T8686 arg1Of pathway,signaling
R7346 T8688 T8691 modOf have,to
R7347 T8688 T8703 arg1Of have,","
R7348 T8688 T8704 arg1Of have,[
R7349 T8690 T8688 arg2Of functions,have
R7350 T8690 T8689 arg1Of functions,distinct
R7351 T8692 T8691 arg1Of control,to
R7352 T8694 T8692 arg2Of aspects,control
R7353 T8694 T8693 arg1Of aspects,specific
R7354 T8694 T8695 arg1Of aspects,of
R7355 T8736 T8734 arg1Of p52/RELB,NF-κB
R7356 T8697 T8696 arg1Of development,DC
R7357 T8697 T8698 arg1Of development,and
R7358 T8698 T8695 arg2Of and,of
R7359 T8736 T8735 arg1Of p52/RELB,heterodimer
R7360 T8699 T8698 arg2Of function,and
R7361 T8699 T8700 arg1Of function,[
R7362 T8736 T8737 arg1Of p52/RELB,is
R7363 T8701 T8700 arg2Of 51,[
R7364 T8736 T8738 arg1Of p52/RELB,sufficient
R7365 T8702 T8700 arg3Of ],[
R7366 T8737 T8731 arg2Of is,suggesting
R7367 T8737 T8732 arg1Of is,that
R7368 T8705 T8704 arg2Of 52,[
R7369 T8706 T8704 arg3Of ],[
R7370 T8737 T8739 modOf is,to
R7371 T8738 T8737 arg2Of sufficient,is
R7372 T8740 T8739 arg1Of maintain,to
R7373 T8743 T8740 arg2Of regulation,maintain
R7374 T8804 T8802 arg1Of activation,defective
R7375 T8804 T8803 arg1Of activation,NF-κB
R7376 T8804 T8805 arg1Of activation,is
R7377 T8805 T8800 arg2Of is,suggesting
R7378 T8805 T8801 arg1Of is,that
R7379 T8805 T8806 arg1Of is,not
R7380 T8808 T8805 arg2Of result,is
R7381 T8808 T8807 arg1Of result,a
R7382 T8808 T8809 arg1Of result,of
R7383 T8743 T8741 arg1Of regulation,the
R7384 T8743 T8742 arg1Of regulation,normal
R7385 T8812 T8809 arg2Of expression,of
R7386 T8812 T8810 arg1Of expression,differential
R7387 T8812 T8811 arg1Of expression,TLR
R7388 T8812 T8813 arg1Of expression,on
R7389 T8743 T8744 arg1Of regulation,of
R7390 T8746 T8747 arg1Of homeostasis,and
R7391 T8815 T8813 arg2Of cells,on
R7392 T8815 T8814 arg1Of cells,target
R7393 T8816 T8817 arg1Of LPS,engages
R7394 T8817 T8819 modOf engages,to
R7395 T8817 T8826 arg1Of engages,whereas
R7396 T8818 T8817 arg2Of TLR4,engages
R7397 T8820 T8819 arg1Of activate,to
R7398 T8747 T8744 arg2Of and,of
R7399 T8821 T8822 arg1Of MYD88-dependent,and
R7400 T8747 T8745 arg1Of and,DC
R7401 T8823 T8822 arg2Of TRIF-dependent,and
R7402 T8824 T8820 arg2Of pathways,activate
R7403 T8824 T8821 arg1Of pathways,MYD88-dependent
R7404 T8824 T8823 arg1Of pathways,TRIF-dependent
R7405 T8826 T8825 arg1Of whereas,","
R7406 T8827 T8828 arg2Of TLR3,stimulated
R7407 T8827 T8835 arg1Of TLR3,triggers
R7408 T8748 T8747 arg2Of maturation,and
R7409 T8831 T8830 arg1Of I,poly
R7410 T8831 T8832 arg1Of I,:
R7411 T8751 T8749 arg1Of basis,The
R7412 T8833 T8828 arg1Of C,stimulated
R7413 T8833 T8829 arg2Of C,by
R7414 T8833 T8831 arg1Of C,I
R7415 T8835 T8826 arg2Of triggers,whereas
R7416 T8835 T8834 arg1Of triggers,only
R7417 T8837 T8835 arg2Of signaling,triggers
R7418 T8837 T8836 arg1Of signaling,TRIF-dependent
R7419 T8837 T8838 arg1Of signaling,[
R7420 T8751 T8750 arg1Of basis,molecular
R7421 T8751 T8752 arg2Of basis,by
R7422 T8751 T8753 arg1Of basis,which
R7423 T8751 T8763 arg1Of basis,remains
R7424 T8839 T8838 arg2Of 53,[
R7425 T8751 T8765 arg1Of basis,be
R7426 T8840 T8838 arg3Of ],[
R7427 T8751 T8766 arg2Of basis,determined
R7428 T8756 T8754 arg1Of mutation,the
R7429 T8844 T8841 arg1Of activation,The
R7430 T8844 T8842 arg1Of activation,defective
R7431 T8844 T8843 arg1Of activation,NF-κB
R7432 T8844 T8845 arg1Of activation,by
R7433 T8844 T8848 arg1Of activation,suggests
R7434 T8847 T8845 arg2Of stimuli,by
R7435 T8847 T8846 arg1Of stimuli,both
R7436 T8756 T8755 arg1Of mutation,Sharpin
R7437 T8852 T8850 arg1Of mutation,the
R7438 T8852 T8851 arg1Of mutation,Sharpin
R7439 T8852 T8853 arg1Of mutation,interferes
R7440 T8756 T8757 arg1Of mutation,causes
R7441 T8853 T8848 arg2Of interferes,suggests
R7442 T8853 T8849 arg1Of interferes,that
R7443 T8853 T8854 arg1Of interferes,with
R7444 T8757 T8752 arg1Of causes,by
R7445 T8857 T8858 arg1Of adaptors,or
R7446 T8760 T8757 arg2Of activation,causes
R7447 T8858 T8854 arg2Of or,with
R7448 T8858 T8855 arg1Of or,the
R7449 T8858 T8856 arg1Of or,protein
R7450 T8858 T8860 arg2Of or,shared
R7451 T8859 T8858 arg2Of kinases,or
R7452 T8864 T8860 arg1Of pathways,shared
R7453 T8864 T8861 arg2Of pathways,by
R7454 T8864 T8862 arg1Of pathways,both
R7455 T8864 T8863 arg1Of pathways,signaling
R7456 T8864 T8865 arg1Of pathways,","
R7457 T8864 T8867 arg1Of pathways,as
R7458 T8867 T8866 arg1Of as,such
R7459 T8868 T8869 arg1Of RIP1,and
R7460 T8760 T8758 arg2Of activation,reduced
R7461 T8869 T8867 arg2Of and,as
R7462 T8760 T8759 arg1Of activation,NF-κB
R7463 T8760 T8761 arg1Of activation,in
R7464 T8762 T8761 arg2Of BMDC,in
R7465 T8869 T8871 arg1Of and,[
R7466 T8766 T8763 arg2Of determined,remains
R7467 T8870 T8869 arg2Of TRAF6,and
R7468 T8872 T8871 arg2Of 18,[
R7469 T8873 T8871 arg3Of ],[
R7470 T8766 T8764 arg1Of determined,to
R7471 T8875 T8874 arg1Of studies,Recent
R7472 T8875 T8876 arg1Of studies,demonstrated
R7473 T8766 T8765 arg2Of determined,be
R7474 T8767 T8768 arg1Of LPS,and
R7475 T8878 T8879 arg1Of SHARPIN,interacts
R7476 T8879 T8876 arg2Of interacts,demonstrated
R7477 T8879 T8877 arg1Of interacts,that
R7478 T8879 T8880 arg1Of interacts,with
R7479 T8881 T8880 arg2Of HOIP,with
R7480 T8881 T8882 modOf HOIP,to
R7481 T8768 T8771 arg1Of and,:
R7482 T8883 T8882 arg1Of form,to
R7483 T8884 T8883 arg2Of LUBAC,form
R7484 T8884 T8885 arg1Of LUBAC,that
R7485 T8884 T8886 arg1Of LUBAC,exerts
R7486 T8770 T8768 arg2Of I,and
R7487 T8889 T8886 arg2Of activity,exerts
R7488 T8889 T8887 arg1Of activity,its
R7489 T8889 T8888 arg1Of activity,linear-ubiquitin-chain-ligase
R7490 T8889 T8890 arg1Of activity,on
R7491 T8770 T8769 arg1Of I,poly
R7492 T8772 T8767 arg1Of C,LPS
R7493 T8894 T8891 arg1Of RIP1,NF-κB
R7494 T8894 T8892 arg1Of RIP1,signaling
R7495 T8894 T8893 arg1Of RIP1,players
R7496 T8894 T8895 arg1Of RIP1,and
R7497 T8895 T8890 arg2Of and,on
R7498 T8895 T8900 arg1Of and,","
R7499 T8896 T8895 arg2Of NEMO,and
R7500 T8896 T8897 arg1Of NEMO,[
R7501 T8772 T8770 arg1Of C,I
R7502 T8898 T8897 arg2Of 7,[
R7503 T8899 T8897 arg3Of ],[
R7504 T8772 T8773 arg2Of C,used
R7505 T8772 T8775 arg1Of C,are
R7506 T8773 T8774 arg1Of used,here
R7507 T8777 T8775 arg2Of ligands,are
R7508 T8903 T8900 arg2Of step,","
R7509 T8903 T8901 arg1Of step,an
R7510 T8903 T8902 arg1Of step,essential
R7511 T8903 T8904 arg1Of step,for
R7512 T8777 T8776 arg1Of ligands,well-defined
R7513 T8777 T8778 arg1Of ligands,that
R7514 T8777 T8780 arg1Of ligands,engage
R7515 T8780 T8779 arg1Of engage,specifically
R7516 T8908 T8904 arg2Of activation,for
R7517 T8908 T8905 arg1Of activation,intact
R7518 T8908 T8906 arg1Of activation,TNFα-stimulated
R7519 T8908 T8907 arg1Of activation,NF-κB
R7520 T8912 T8909 arg1Of mutation,The
R7521 T8912 T8910 arg1Of mutation,Sharpin
R7522 T8912 T8911 arg1Of mutation,null
R7523 T8912 T8913 arg1Of mutation,disrupts
R7524 T8780 T8784 arg1Of engage,","
R7525 T8912 T8918 arg1Of mutation,abrogates
R7526 T8780 T8785 arg1Of engage,respectively
R7527 T8913 T8917 arg1Of disrupts,and
R7528 T8781 T8782 arg1Of TLR4,and
R7529 T8782 T8780 arg2Of and,engage
R7530 T8916 T8913 arg2Of process,disrupts
R7531 T8916 T8914 arg1Of process,the
R7532 T8916 T8915 arg1Of process,ubiquitylation
R7533 T8918 T8917 arg2Of abrogates,and
R7534 T8783 T8782 arg2Of TLR3,and
R7535 T8788 T8786 arg1Of profile,The
R7536 T8923 T8918 arg2Of pathway,abrogates
R7537 T8923 T8919 arg1Of pathway,the
R7538 T8923 T8920 arg1Of pathway,TNFα-induced
R7539 T8923 T8921 arg1Of pathway,NF-κB
R7540 T8923 T8922 arg1Of pathway,signaling
R7541 T8925 T8926 arg1Of TNFR,and
R7542 T8926 T8929 arg1Of and,share
R7543 T8927 T8926 arg2Of TLR,and
R7544 T8929 T8924 arg2Of share,Since
R7545 T8929 T8928 arg1Of share,partially
R7546 T8788 T8787 arg1Of profile,expression
R7547 T8788 T8789 arg1Of profile,of
R7548 T8788 T8793 arg1Of profile,is
R7549 T8933 T8929 arg2Of cascades,share
R7550 T8933 T8930 arg1Of cascades,their
R7551 T8933 T8931 arg1Of cascades,downstream
R7552 T8933 T8932 arg1Of cascades,signaling
R7553 T8788 T8794 arg1Of profile,similar
R7554 T8938 T8935 arg1Of regulation,a
R7555 T8938 T8936 arg1Of regulation,similar
R7556 T8938 T8937 arg1Of regulation,ubiquitin-mediated
R7557 T8938 T8939 arg1Of regulation,may
R7558 T8938 T8940 arg1Of regulation,hold
R7559 T8938 T8941 arg1Of regulation,true
R7560 T8940 T8924 arg1Of hold,Since
R7561 T8940 T8934 arg1Of hold,","
R7562 T8940 T8939 arg2Of hold,may
R7563 T8792 T8789 arg2Of complexes,of
R7564 T8941 T8940 arg2Of true,hold
R7565 T8941 T8942 arg1Of true,for
R7566 T8943 T8942 arg2Of SHARPIN,for
R7567 T8943 T8944 arg1Of SHARPIN,in
R7568 T8943 T8949 arg1Of SHARPIN,:
R7569 T8945 T8946 arg1Of LPS-,and
R7570 T8946 T8944 arg2Of and,in
R7571 T8947 T8946 arg2Of poly,and
R7572 T8947 T8948 arg1Of poly,I
R7573 T8792 T8790 arg1Of complexes,surface
R7574 T8792 T8791 arg1Of complexes,TLR4
R7575 T8793 T8800 modOf is,suggesting
R7576 T8952 T8949 arg2Of activation,:
R7577 T8952 T8950 arg1Of activation,C-induced
R7578 T8952 T8951 arg1Of activation,NF-κB
R7579 T8794 T8793 arg2Of similar,is
R7580 T8954 T8953 arg2Of summary,In
R7581 T8794 T8795 arg1Of similar,between
R7582 T8796 T8797 arg1Of WT,and
R7583 T8958 T8956 arg1Of study,the
R7584 T8958 T8957 arg1Of study,present
R7585 T8958 T8959 arg1Of study,identified
R7586 T8959 T8953 arg1Of identified,In
R7587 T8959 T8955 arg1Of identified,","
R7588 T8962 T8959 arg2Of role,identified
R7589 T8962 T8960 arg1Of role,an
R7590 T8962 T8961 arg1Of role,indispensible
R7591 T8962 T8963 arg1Of role,of
R7592 T8962 T8965 arg1Of role,in
R7593 T8964 T8963 arg2Of SHARPIN,of
R7594 T8797 T8795 arg2Of and,between
R7595 T8799 T8797 arg2Of BMDC,and
R7596 T8967 T8965 arg2Of production,in
R7597 T8967 T8966 arg1Of production,the
R7598 T8967 T8968 arg1Of production,of
R7599 T8970 T8969 arg1Of mediators,pro-inflammatory
R7600 T8970 T8971 arg1Of mediators,and
R7601 T8971 T8968 arg2Of and,of
R7602 T8974 T8971 arg2Of signaling,and
R7603 T8974 T8972 arg1Of signaling,TLR-induced
R7604 T8974 T8973 arg1Of signaling,NF-κB
R7605 T8799 T8798 arg1Of BMDC,cpdm
R7606 T8998 T8994 arg2Of differentiation,between
R7607 T8977 T8976 arg1Of Th1-stimulating,impaired
R7608 T8978 T8975 arg1Of ability,The
R7609 T8978 T8977 arg1Of ability,Th1-stimulating
R7610 T8978 T8979 arg1Of ability,of
R7611 T8978 T8982 arg1Of ability,may
R7612 T8978 T8983 arg1Of ability,account
R7613 T8981 T8979 arg2Of DC,of
R7614 T8981 T8980 arg1Of DC,Sharpin-deficient
R7615 T8983 T8982 arg2Of account,may
R7616 T8983 T8984 arg1Of account,for
R7617 T8998 T8995 arg1Of differentiation,Th1
R7618 T8998 T8997 arg1Of differentiation,Th2
R7619 T8988 T8984 arg2Of phenotype,for
R7620 T8988 T8985 arg1Of phenotype,the
R7621 T8988 T8986 arg1Of phenotype,Th2-dominant
R7622 T8988 T8987 arg1Of phenotype,inflammatory
R7623 T8988 T8989 arg1Of phenotype,of
R7624 T9000 T8999 arg2Of critical,is
R7625 T8991 T8989 arg2Of mice,of
R7626 T8991 T8990 arg1Of mice,cpdm
R7627 T9000 T9001 arg1Of critical,for
R7628 T9003 T9001 arg2Of homeostasis,for
R7629 T8993 T8992 arg1Of balance,The
R7630 T8993 T8994 arg1Of balance,between
R7631 T8993 T8999 arg1Of balance,is
R7632 T8993 T9000 arg1Of balance,critical
R7633 T8995 T8996 arg1Of Th1,and
R7634 T8997 T8996 arg2Of Th2,and
R7635 T9003 T9002 arg1Of homeostasis,immune
R7636 T9006 T9004 arg1Of understanding,A
R7637 T9006 T9005 arg1Of understanding,better
R7638 T9006 T9007 arg1Of understanding,of
R7639 T9006 T9013 arg1Of understanding,will
R7640 T9006 T9014 arg1Of understanding,help
R7642 T9006 T9015 arg1Of understanding,design
R7643 T9008 T9007 arg2Of how,of
R7646 T9010 T9009 arg1Of balance,such
R7647 T9010 T9011 arg1Of balance,is
R7648 T9010 T9012 arg2Of balance,maintained
R7649 T9012 T9008 arg1Of maintained,how
R7650 T9012 T9011 arg2Of maintained,is
R7651 T9015 T9013 arg2Of design,will
R7652 T9015 T9014 arg2Of design,help
R7653 T9017 T9015 arg2Of treatment,design
R7654 T9017 T9016 arg1Of treatment,cytokine
R7655 T9017 T9018 arg1Of treatment,for
R7656 T9017 T9030 arg1Of treatment,","
R7657 T9017 T9032 arg1Of treatment,as
R7658 T9020 T9018 arg2Of diseases,for
R7659 T9020 T9019 arg1Of diseases,human
R7660 T9020 T9021 arg1Of diseases,with
R7661 T9024 T9021 arg2Of secretion,with
R7662 T9024 T9022 arg1Of secretion,Th2-biased
R7663 T9024 T9023 arg1Of secretion,cytokine
R7664 T9024 T9025 arg1Of secretion,similar
R7665 T9025 T9026 arg1Of similar,to
R7666 T9029 T9026 arg2Of cpdm,to
R7667 T9029 T9027 arg1Of cpdm,the
R7668 T9029 T9028 arg1Of cpdm,mouse
R7669 T9032 T9031 arg1Of as,such
R7670 T9033 T9034 arg1Of allergies,and
R7671 T9034 T9032 arg2Of and,as
R7672 T9036 T9034 arg2Of syndromes,and
R7673 T9036 T9035 arg1Of syndromes,hypereosinophilic
R7864 T9603 T9602 arg1Of Statement,Ethics
R7865 T9606 T9604 arg1Of work,All
R7866 T9606 T9605 arg1Of work,mouse
R7867 T9606 T9607 arg1Of work,was
R7868 T9606 T9608 arg2Of work,carried
R7869 T9608 T9607 arg2Of carried,was
R7870 T9608 T9609 arg1Of carried,out
R7871 T9608 T9610 arg1Of carried,in
R7872 T9608 T9613 arg1Of carried,with
R7873 T9612 T9610 arg2Of accordance,in
R7874 T9612 T9611 arg1Of accordance,strict
R7875 T9614 T9613 arg2Of protocols,with
R7876 T9614 T9615 arg2Of protocols,approved
R7877 T9620 T9618 arg1Of Care,Institutional
R7878 T9620 T9619 arg1Of Care,Animal
R7879 T9620 T9621 arg1Of Care,and
R7880 T9621 T9615 arg1Of and,approved
R7881 T9621 T9616 arg2Of and,by
R7882 T9621 T9617 arg1Of and,the
R7883 T9623 T9621 arg2Of Committees,and
R7884 T9623 T9622 arg1Of Committees,Use
R8035 T9789 T9787 arg1Of colonies,Specific-pathogen
R8036 T9789 T9788 arg1Of colonies,free
R8037 T9789 T9790 arg1Of colonies,of
R8038 T9789 T9792 arg1Of colonies,(
R8039 T9789 T9797 arg1Of colonies,and
R8040 T9791 T9790 arg2Of C57BL/KaLawRij-Sharpincpdm/RijSunJ,of
R8041 T9793 T9792 arg2Of JR,(
R8042 T9793 T9795 arg1Of JR,7599
R8043 T9795 T9794 arg1Of 7599,#
R8044 T9796 T9792 arg3Of ),(
R8045 T9797 T9800 arg1Of and,were
R8046 T9797 T9801 arg2Of and,obtained
R8047 T9797 T9813 arg1Of and,were
R8048 T9797 T9814 arg2Of and,maintained
R8049 T9799 T9797 arg2Of mice,and
R8050 T9799 T9798 arg1Of mice,WT
R8051 T9801 T9800 arg2Of obtained,were
R8052 T9801 T9802 arg1Of obtained,from
R8053 T9801 T9812 arg1Of obtained,and
R8054 T9805 T9802 arg2Of Laboratory,from
R8055 T9805 T9803 arg1Of Laboratory,The
R8056 T9805 T9804 arg1Of Laboratory,Jackson
R8057 T9805 T9806 arg1Of Laboratory,(
R8058 T9808 T9806 arg2Of Harbor,(
R8059 T9808 T9807 arg1Of Harbor,Bar
R8060 T9808 T9809 arg1Of Harbor,","
R8061 T9810 T9809 arg2Of ME,","
R8062 T9811 T9806 arg3Of ),(
R8063 T9814 T9812 arg2Of maintained,and
R8064 T9814 T9813 arg2Of maintained,were
R8065 T9814 T9815 arg1Of maintained,in
R8066 T9818 T9815 arg2Of facility,in
R8067 T9818 T9816 arg1Of facility,a
R8068 T9818 T9817 arg1Of facility,barrier
R8069 T9821 T9819 arg1Of controls,Normal
R8070 T9821 T9820 arg1Of controls,littermate
R8071 T9821 T9822 arg1Of controls,were
R8072 T9822 T9825 arg1Of were,or
R8073 T9824 T9822 arg2Of +/+,were
R8074 T9824 T9823 arg1Of +/+,either
R8075 T9829 T9826 arg1Of animals,+/Sharpincpdm.
R8076 T9829 T9827 arg1Of animals,These
R8077 T9829 T9828 arg1Of animals,control
R8078 T9829 T9830 arg1Of animals,were
R8079 T9829 T9832 arg1Of animals,indistinguishable
R8080 T9829 T9834 arg1Of animals,are
R8081 T9829 T9835 arg2Of animals,referred
R8082 T9830 T9833 arg1Of were,and
R8083 T9832 T9830 arg2Of indistinguishable,were
R8084 T9832 T9831 arg1Of indistinguishable,phenotypically
R8085 T9833 T9825 arg2Of and,or
R8086 T9835 T9833 arg2Of referred,and
R8087 T9835 T9834 arg2Of referred,are
R8088 T9835 T9836 arg1Of referred,to
R8089 T9835 T9837 arg1Of referred,as
R8090 T9838 T9837 arg2Of WT,as
R8091 T9839 T9840 arg1Of Sex-matched,WT
R8092 T9839 T9841 arg1Of Sex-matched,and
R8093 T9842 T9841 arg2Of mutant,and
R8094 T9843 T9839 arg1Of mice,Sex-matched
R8095 T9843 T9842 arg1Of mice,mutant
R8096 T9843 T9844 arg1Of mice,were
R8097 T9843 T9845 arg2Of mice,used
R8098 T9845 T9844 arg2Of used,were
R8099 T9845 T9846 arg1Of used,at
R8100 T9848 T9846 arg2Of weeks,at
R8101 T9848 T9847 arg1Of weeks,6–10
R8102 T9848 T9849 arg1Of weeks,of
R8103 T9850 T9849 arg2Of age,of
R8104 T9853 T9851 arg2Of experiments,For
R8105 T9853 T9852 arg1Of experiments,some
R8106 T9856 T9855 arg1Of mice,cpdm
R8107 T9856 T9857 arg1Of mice,were
R8108 T9856 T9858 arg2Of mice,crossed
R8109 T9858 T9851 arg1Of crossed,For
R8110 T9858 T9854 arg1Of crossed,","
R8111 T9858 T9857 arg2Of crossed,were
R8112 T9858 T9859 arg1Of crossed,with
R8113 T9858 T9862 arg1Of crossed,with
R8114 T9861 T9859 arg2Of mice,with
R8115 T9861 T9860 arg1Of mice,transgenic
R8116 T9866 T9862 arg2Of chromosome,with
R8117 T9866 T9863 arg1Of chromosome,a
R8118 T9866 T9864 arg1Of chromosome,bacterial
R8119 T9866 T9865 arg1Of chromosome,artificial
R8120 T9866 T9867 arg1Of chromosome,(
R8121 T9866 T9870 arg1Of chromosome,containing
R8122 T9868 T9867 arg2Of BAC,(
R8123 T9869 T9867 arg3Of ),(
R8124 T9873 T9870 arg2Of gene,containing
R8125 T9873 T9871 arg1Of gene,the
R8126 T9873 T9872 arg1Of gene,Sharpin
R8127 T9873 T9874 arg1Of gene,(
R8128 T9877 T9876 arg2Of RP24-173I23,(
R8129 T9878 T9876 arg3Of ),(
R8130 T9879 T9874 arg2Of 1Sun/Sun,(
R8131 T9879 T9875 arg1Of 1Sun/Sun,FVB/NJ-Tg
R8132 T9879 T9876 arg1Of 1Sun/Sun,(
R8133 T9879 T9880 arg1Of 1Sun/Sun,","
R8134 T9881 T9880 arg2Of JR,","
R8135 T9881 T9883 arg1Of JR,8279
R8136 T9883 T9882 arg1Of 8279,#
R8137 T9884 T9874 arg3Of ),(
R8138 T9886 T9885 arg1Of mice,These
R8139 T9886 T9887 arg1Of mice,were
R8140 T9886 T9888 arg2Of mice,backcrossed
R8141 T9888 T9887 arg2Of backcrossed,were
R8142 T9888 T9889 arg1Of backcrossed,onto
R8143 T9888 T9893 arg1Of backcrossed,and
R8144 T9892 T9889 arg2Of background,onto
R8145 T9892 T9890 arg1Of background,the
R8146 T9892 T9891 arg1Of background,C57BL/KaLawRij-Sharpincpdm/RijSunJ
R8147 T9895 T9894 arg1Of mice,N4
R8148 T9895 T9896 arg1Of mice,were
R8149 T9895 T9897 arg2Of mice,used
R8150 T9897 T9893 arg2Of used,and
R8151 T9897 T9896 arg2Of used,were
R8152 T9897 T9898 arg1Of used,in
R8153 T9900 T9898 arg2Of experiments,in
R8154 T9900 T9899 arg1Of experiments,the
R8155 T9900 T9901 arg2Of experiments,reported
R8156 T9901 T9902 arg1Of reported,here
R8157 T9905 T9903 arg1Of work,All
R8158 T9905 T9904 arg1Of work,mouse
R8159 T9905 T9906 arg1Of work,was
R8160 T9905 T9907 arg2Of work,carried
R8161 T9907 T9906 arg2Of carried,was
R8162 T9907 T9908 arg1Of carried,out
R8163 T9907 T9909 arg1Of carried,in
R8164 T9911 T9909 arg2Of accordance,in
R8165 T9911 T9910 arg1Of accordance,strict
R8166 T9911 T9912 arg1Of accordance,with
R8167 T9915 T9912 arg2Of protocols,with
R8168 T9915 T9913 arg1Of protocols,the
R8169 T9915 T9914 arg2Of protocols,approved
R8170 T9920 T9918 arg1Of Care,Institutional
R8171 T9920 T9919 arg1Of Care,Animal
R8172 T9920 T9921 arg1Of Care,and
R8173 T9921 T9907 arg1Of and,carried
R8174 T9921 T9916 arg2Of and,by
R8175 T9921 T9917 arg1Of and,the
R8176 T9923 T9921 arg2Of Committee,and
R8177 T9923 T9922 arg1Of Committee,Use
R8350 T10135 T10136 arg1Of Constructs,and
R8351 T10137 T10136 arg2Of transfection,and
R8352 T10140 T10138 arg1Of DNA,The
R8353 T10140 T10139 arg1Of DNA,complementary
R8354 T10140 T10141 arg1Of DNA,(
R8355 T10140 T10144 arg1Of DNA,of
R8356 T10140 T10149 arg1Of DNA,was
R8357 T10140 T10150 arg2Of DNA,cloned
R8358 T10140 T10152 arg2Of DNA,amplified
R8359 T10142 T10141 arg2Of cDNA,(
R8360 T10143 T10141 arg3Of ),(
R8361 T10148 T10144 arg2Of gene,of
R8362 T10148 T10145 arg1Of gene,the
R8363 T10148 T10146 arg1Of gene,mouse
R8364 T10148 T10147 arg1Of gene,Sharpin
R8365 T10150 T10151 arg1Of cloned,and
R8366 T10151 T10149 arg2Of and,was
R8367 T10151 T10153 arg1Of and,from
R8368 T10152 T10151 arg2Of amplified,and
R8369 T10156 T10153 arg2Of extracts,from
R8370 T10156 T10154 arg1Of extracts,RAW264.7
R8371 T10156 T10155 arg1Of extracts,RNA
R8372 T10159 T10157 arg1Of sequences,The
R8373 T10159 T10158 arg1Of sequences,primer
R8374 T10159 T10160 arg1Of sequences,were
R8375 T10160 T10161 arg1Of were,forward
R8376 T10160 T10162 arg1Of were,","
R8377 T10160 T10173 arg1Of were,;
R8378 T10172 T10160 arg2Of GGT,were
R8379 T10172 T10163 arg1Of GGT,5′-CC
R8380 T10172 T10164 arg1Of GGT,ATG
R8381 T10172 T10165 arg1Of GGT,GCG
R8382 T10172 T10166 arg1Of GGT,ATG
R8383 T10172 T10167 arg1Of GGT,TCG
R8384 T10172 T10168 arg1Of GGT,CCG
R8385 T10172 T10169 arg1Of GGT,CCC
R8386 T10172 T10170 arg1Of GGT,GCC
R8387 T10172 T10171 arg1Of GGT,GGC
R8388 T10174 T10175 arg1Of reverse,","
R8389 T10179 T10176 arg1Of CTA,5′-
R8390 T10179 T10177 arg1Of CTA,AAG
R8391 T10179 T10178 arg1Of CTA,CTT
R8392 T10184 T10180 arg1Of AGC,GGT
R8393 T10184 T10181 arg1Of AGC,GGA
R8394 T10184 T10182 arg1Of AGC,AGC
R8395 T10184 T10183 arg1Of AGC,TGC
R8396 T10186 T10175 arg2Of A.,","
R8397 T10186 T10179 arg1Of A.,CTA
R8398 T10186 T10184 arg1Of A.,AGC
R8399 T10186 T10185 arg1Of A.,AAG
R8400 T10189 T10187 arg1Of cDNA,The
R8401 T10189 T10188 arg1Of cDNA,Sharpin
R8402 T10189 T10190 arg1Of cDNA,was
R8403 T10189 T10191 arg2Of cDNA,cloned
R8404 T10191 T10173 arg2Of cloned,;
R8405 T10191 T10174 arg1Of cloned,reverse
R8406 T10191 T10190 arg2Of cloned,was
R8407 T10191 T10192 arg1Of cloned,into
R8408 T10195 T10192 arg2Of pFLAG-CMV-2,into
R8409 T10195 T10193 arg1Of pFLAG-CMV-2,expression
R8410 T10195 T10194 arg1Of pFLAG-CMV-2,vector
R8411 T10197 T10196 arg1Of fibroblasts,Murine
R8412 T10197 T10200 arg2Of fibroblasts,were
R8413 T10197 T10201 arg1Of fibroblasts,were
R8414 T10197 T10202 arg2Of fibroblasts,used
R8415 T10199 T10200 arg1Of macrophages,were
R8416 T10200 T10198 arg1Of were,and
R8417 T10202 T10201 arg2Of used,were
R8418 T10202 T10203 modOf used,to
R8419 T10204 T10203 arg1Of express,to
R8420 T10207 T10204 arg2Of protein,express
R8421 T10207 T10205 arg1Of protein,recombinant
R8422 T10207 T10206 arg1Of protein,SHARPIN
R8423 T10208 T10209 arg1Of Cells,(
R8424 T10208 T10212 arg1Of Cells,were
R8425 T10208 T10213 arg2Of Cells,seeded
R8426 T10210 T10209 arg2Of 2×104,(
R8427 T10211 T10209 arg3Of ),(
R8428 T10213 T10212 arg2Of seeded,were
R8429 T10213 T10214 arg1Of seeded,in
R8430 T10213 T10219 arg1Of seeded,day
R8431 T10213 T10220 arg1Of seeded,before
R8432 T10217 T10214 arg2Of plates,in
R8433 T10217 T10215 arg1Of plates,96-well
R8434 T10217 T10216 arg2Of plates,treated
R8435 T10219 T10218 arg1Of day,the
R8436 T10221 T10220 arg2Of transfection,before
R8437 T10224 T10222 arg2Of incubation,After
R8438 T10224 T10223 arg1Of incubation,overnight
R8439 T10229 T10226 arg1Of plasmids,200
R8440 T10229 T10227 arg1Of plasmids,ng
R8441 T10229 T10228 arg1Of plasmids,pFLAG-SHARPIN
R8442 T10229 T10230 arg1Of plasmids,were
R8443 T10229 T10231 arg2Of plasmids,transfected
R8444 T10231 T10222 arg1Of transfected,After
R8445 T10231 T10225 arg1Of transfected,","
R8446 T10231 T10230 arg2Of transfected,were
R8447 T10231 T10232 arg1Of transfected,with
R8448 T10235 T10232 arg2Of Lipofectamine,with
R8449 T10235 T10233 arg1Of Lipofectamine,0.5
R8450 T10235 T10234 arg1Of Lipofectamine,ul
R8451 T10235 T10236 arg1Of Lipofectamine,2000
R8452 T10238 T10237 arg1Of hours,24
R8453 T10239 T10238 arg1Of later,hours
R8454 T10241 T10242 arg1Of cells,were
R8455 T10241 T10243 arg2Of cells,incubated
R8456 T10243 T10239 arg1Of incubated,later
R8457 T10243 T10240 arg1Of incubated,","
R8458 T10243 T10242 arg2Of incubated,were
R8459 T10243 T10244 arg1Of incubated,with
R8460 T10247 T10244 arg2Of medium,with
R8461 T10247 T10245 arg1Of medium,fresh
R8462 T10247 T10246 arg1Of medium,culture
R8463 T10251 T10248 arg2Of hours,After
R8464 T10251 T10249 arg1Of hours,another
R8465 T10251 T10250 arg1Of hours,24
R8466 T10253 T10254 arg1Of cells,were
R8467 T10253 T10255 arg2Of cells,lysed
R8468 T10253 T10257 arg1Of cells,confirm
R8469 T10255 T10248 arg1Of lysed,After
R8470 T10255 T10252 arg1Of lysed,","
R8471 T10255 T10254 arg2Of lysed,were
R8472 T10257 T10255 arg3Of confirm,lysed
R8473 T10257 T10256 arg1Of confirm,to
R8474 T10260 T10257 arg2Of expression,confirm
R8475 T10260 T10258 arg1Of expression,the
R8476 T10260 T10259 arg1Of expression,FLAG-SHARPIN
R8477 T10260 T10261 arg1Of expression,by
R8478 T10262 T10261 arg2Of immunoblots,by
R8479 T10262 T10263 arg1Of immunoblots,with
R8480 T10264 T10263 arg2Of anti-FLAG,with
R8481 T10265 T10266 arg1Of Cells,with
R8482 T10265 T10270 arg2Of Cells,transfected
R8483 T10265 T10275 arg1Of Cells,were
R8484 T10265 T10276 arg2Of Cells,used
R8485 T10266 T10269 arg1Of with,and
R8486 T10268 T10266 arg2Of transfection,with
R8487 T10268 T10267 arg1Of transfection,no
R8488 T10270 T10269 arg2Of transfected,and
R8489 T10270 T10271 arg1Of transfected,with
R8490 T10274 T10271 arg2Of pFLAG-CMV-2,with
R8491 T10274 T10272 arg1Of pFLAG-CMV-2,empty
R8492 T10274 T10273 arg1Of pFLAG-CMV-2,vector
R8493 T10276 T10275 arg2Of used,were
R8494 T10276 T10277 arg1Of used,as
R8495 T10279 T10277 arg2Of control,as
R8496 T10279 T10278 arg1Of control,negative
R8497 T10279 T10280 arg1Of control,in
R8498 T10283 T10280 arg2Of experiments,in
R8499 T10283 T10281 arg1Of experiments,all
R8500 T10283 T10282 arg1Of experiments,transfection
R8552 T10381 T10382 arg1Of Generation,of
R8553 T10383 T10382 arg2Of BMDC,of
R8554 T10384 T10385 arg1Of BMDC,were
R8555 T10384 T10386 arg2Of BMDC,developed
R8556 T10386 T10385 arg2Of developed,were
R8557 T10386 T10387 arg1Of developed,as
R8558 T10386 T10393 arg1Of developed,","
R8559 T10386 T10394 arg1Of developed,[
R8560 T10389 T10388 arg1Of reported,previously
R8561 T10391 T10387 arg2Of 54,as
R8562 T10391 T10389 arg1Of 54,reported
R8563 T10391 T10390 arg2Of 54,[
R8564 T10392 T10390 arg3Of ],[
R8565 T10395 T10394 arg2Of 55,[
R8566 T10396 T10394 arg3Of ],[
R8567 T10397 T10398 arg1Of Cells,were
R8568 T10397 T10399 arg2Of Cells,collected
R8569 T10399 T10398 arg2Of collected,were
R8570 T10399 T10400 arg1Of collected,after
R8571 T10402 T10400 arg2Of days,after
R8572 T10402 T10401 arg1Of days,10–12
R8573 T10402 T10403 arg1Of days,of
R8574 T10404 T10403 arg2Of culture,of
R8575 T10407 T10405 arg1Of yield,The
R8576 T10407 T10406 arg1Of yield,cell
R8577 T10407 T10408 arg1Of yield,was
R8578 T10410 T10408 arg2Of cells/mouse,was
R8579 T10410 T10409 arg1Of cells/mouse,2–3×107
R8580 T10410 T10411 arg1Of cells/mouse,with
R8581 T10412 T10413 arg1Of 80–95,%
R8582 T10414 T10411 arg2Of BMDC,with
R8583 T10414 T10412 arg1Of BMDC,80–95
R8828 T10676 T10677 arg1Of Phenotype,of
R8829 T10678 T10679 arg1Of BMDC,and
R8830 T10680 T10679 arg2Of splenic,and
R8831 T10682 T10677 arg2Of subsets,of
R8832 T10682 T10678 arg1Of subsets,BMDC
R8833 T10682 T10680 arg1Of subsets,splenic
R8834 T10682 T10681 arg1Of subsets,DC
R8835 T10684 T10683 arg1Of phenotype,The
R8836 T10684 T10685 arg1Of phenotype,of
R8837 T10684 T10687 arg1Of phenotype,was
R8838 T10684 T10688 arg2Of phenotype,determined
R8839 T10686 T10685 arg2Of BMDC,of
R8840 T10688 T10687 arg2Of determined,was
R8841 T10688 T10689 arg1Of determined,before
R8842 T10688 T10691 arg1Of determined,after
R8843 T10688 T10695 arg1Of determined,in
R8844 T10689 T10690 arg1Of before,and
R8845 T10691 T10690 arg2Of after,and
R8846 T10692 T10693 arg1Of 24,hour
R8847 T10694 T10689 arg2Of culture,before
R8848 T10694 T10691 arg2Of culture,after
R8849 T10694 T10692 arg1Of culture,24
R8850 T10695 T10696 arg1Of in,the
R8851 T10695 T10698 arg1Of in,of
R8852 T10697 T10695 arg2Of presence,in
R8853 T10699 T10700 arg1Of 100,ng/mL
R8854 T10701 T10695 arg3Of LPS,in
R8855 T10701 T10699 arg1Of LPS,100
R8856 T10703 T10702 arg1Of cells,The
R8857 T10703 T10704 arg1Of cells,were
R8858 T10703 T10705 arg2Of cells,incubated
R8859 T10703 T10730 arg2Of cells,incubated
R8860 T10705 T10706 arg1Of incubated,in
R8861 T10705 T10708 arg1Of incubated,with
R8862 T10705 T10729 arg1Of incubated,and
R8863 T10707 T10706 arg2Of PBS,in
R8864 T10709 T10710 arg1Of 0.1,%
R8865 T10711 T10709 arg1Of NaN3,0.1
R8866 T10711 T10712 arg1Of NaN3,","
R8867 T10712 T10716 arg1Of ",",and
R8868 T10713 T10714 arg1Of 1,%
R8869 T10715 T10712 arg2Of BSA,","
R8870 T10715 T10713 arg1Of BSA,1
R8871 T10716 T10708 arg2Of and,with
R8872 T10716 T10727 arg1Of and,","
R8873 T10716 T10728 arg2Of and,washed
R8874 T10717 T10718 arg1Of 10,%
R8875 T10721 T10716 arg2Of serum,and
R8876 T10721 T10717 arg1Of serum,10
R8877 T10721 T10719 arg1Of serum,normal
R8878 T10721 T10720 arg1Of serum,rabbit
R8879 T10721 T10722 arg1Of serum,for
R8880 T10721 T10725 arg1Of serum,on
R8881 T10724 T10722 arg2Of minutes,for
R8882 T10724 T10723 arg1Of minutes,20
R8883 T10726 T10725 arg2Of ice,on
R8884 T10729 T10704 arg2Of and,were
R8885 T10730 T10729 arg2Of incubated,and
R8886 T10730 T10731 arg1Of incubated,for
R8887 T10730 T10734 arg1Of incubated,on
R8888 T10733 T10731 arg2Of minutes,for
R8889 T10733 T10732 arg1Of minutes,30
R8890 T10735 T10734 arg2Of ice,on
R8891 T10735 T10736 arg1Of ice,with
R8892 T10739 T10736 arg2Of anti-CD11c,with
R8893 T10739 T10737 arg1Of anti-CD11c,Alex
R8894 T10739 T10738 arg1Of anti-CD11c,Fluor-labeled
R8895 T10739 T10740 arg1Of anti-CD11c,(
R8896 T10739 T10745 arg1Of anti-CD11c,in
R8897 T10739 T10750 arg1Of anti-CD11c,(
R8898 T10739 T10756 arg1Of anti-CD11c,","
R8899 T10741 T10740 arg2Of MCD11C20,(
R8900 T10741 T10742 arg1Of MCD11C20,","
R8901 T10743 T10742 arg2Of CALTAG,","
R8902 T10744 T10740 arg3Of ),(
R8903 T10746 T10745 arg2Of combination,in
R8904 T10746 T10747 arg1Of combination,with
R8905 T10749 T10747 arg2Of anti-CD40,with
R8906 T10749 T10748 arg1Of anti-CD40,PE-
R8907 T10751 T10750 arg2Of 3/23,(
R8908 T10751 T10752 arg1Of 3/23,","
R8909 T10754 T10752 arg2Of Biosciences,","
R8910 T10754 T10753 arg1Of Biosciences,BD
R8911 T10755 T10750 arg3Of ),(
R8912 T10757 T10758 arg1Of PE-anti-CD80,(
R8913 T10757 T10763 arg1Of PE-anti-CD80,","
R8914 T10759 T10758 arg2Of 16-10A1,(
R8915 T10759 T10760 arg1Of 16-10A1,","
R8916 T10761 T10760 arg2Of eBioscience,","
R8917 T10762 T10758 arg3Of ),(
R8918 T10763 T10765 arg1Of ",",(
R8919 T10763 T10770 arg1Of ",",","
R8920 T10764 T10763 arg2Of PE-anti-CD86,","
R8921 T10766 T10765 arg2Of P03.1,(
R8922 T10766 T10767 arg1Of P03.1,","
R8923 T10768 T10767 arg2Of eBioscience,","
R8924 T10769 T10765 arg3Of ),(
R8925 T10770 T10756 arg2Of ",",","
R8926 T10771 T10772 arg1Of PE-anti-CD14,(
R8927 T10771 T10777 arg1Of PE-anti-CD14,and
R8928 T10773 T10772 arg2Of Sa2.8,(
R8929 T10773 T10774 arg1Of Sa2.8,","
R8930 T10775 T10774 arg2Of eBioscience,","
R8931 T10776 T10772 arg3Of ),(
R8932 T10777 T10770 arg2Of and,","
R8933 T10779 T10777 arg2Of anti-TLR4,and
R8934 T10779 T10778 arg2Of anti-TLR4,biotinylated
R8935 T10779 T10780 arg1Of anti-TLR4,(
R8936 T10781 T10780 arg2Of BioLegend,(
R8937 T10782 T10780 arg3Of ),(
R8938 T10784 T10783 arg1Of cells,The
R8939 T10784 T10785 arg2Of cells,incubated
R8940 T10784 T10789 arg1Of cells,were
R8941 T10784 T10790 arg2Of cells,washed
R8942 T10784 T10793 arg2Of cells,incubated
R8943 T10785 T10786 arg1Of incubated,with
R8944 T10788 T10786 arg2Of anti-TLR4/MD-2,with
R8945 T10788 T10787 arg2Of anti-TLR4/MD-2,biotinylated
R8946 T10790 T10791 arg1Of washed,twice
R8947 T10790 T10792 arg1Of washed,and
R8948 T10792 T10789 arg2Of and,were
R8949 T10793 T10792 arg2Of incubated,and
R8950 T10793 T10794 arg1Of incubated,for
R8951 T10796 T10794 arg2Of minutes,for
R8952 T10796 T10795 arg1Of minutes,30
R8953 T10796 T10797 arg1Of minutes,on
R8954 T10798 T10797 arg2Of ice,on
R8955 T10798 T10799 arg1Of ice,with
R8956 T10800 T10799 arg2Of avidin-PE,with
R8957 T10802 T10801 arg1Of isolate,To
R8958 T10804 T10802 arg2Of DC,isolate
R8959 T10804 T10803 arg1Of DC,splenic
R8960 T10806 T10802 arg1Of spleens,isolate
R8961 T10806 T10807 arg1Of spleens,were
R8962 T10806 T10809 arg1Of spleens,digested
R8963 T10806 T10811 arg1Of spleens,subject
R8964 T10807 T10801 modOf were,To
R8965 T10807 T10805 arg1Of were,","
R8966 T10809 T10808 arg1Of digested,collagenase
R8967 T10809 T10810 arg1Of digested,and
R8968 T10810 T10807 arg2Of and,were
R8969 T10811 T10810 arg2Of subject,and
R8970 T10811 T10812 arg1Of subject,to
R8971 T10815 T10812 arg2Of centrifugation,to
R8972 T10815 T10813 arg1Of centrifugation,Percoll
R8973 T10815 T10814 arg1Of centrifugation,gradient
R8974 T10817 T10816 arg1Of bands,The
R8975 T10817 T10818 arg1Of bands,at
R8976 T10817 T10823 arg1Of bands,were
R8977 T10817 T10824 arg2Of bands,collected
R8978 T10820 T10821 arg1Of 35–55,%
R8979 T10822 T10818 arg2Of interface,at
R8980 T10822 T10819 arg1Of interface,the
R8981 T10822 T10820 arg1Of interface,35–55
R8982 T10824 T10823 arg2Of collected,were
R8983 T10824 T10825 modOf collected,to
R8984 T10826 T10825 arg1Of stain,to
R8985 T10826 T10827 arg1Of stain,with
R8986 T10828 T10829 arg1Of PE-anti-CD11c,(
R8987 T10828 T10834 arg1Of PE-anti-CD11c,","
R8988 T10830 T10829 arg2Of HL3,(
R8989 T10830 T10831 arg1Of HL3,","
R8990 T10830 T10832 arg1Of HL3,BioLegend
R8991 T10833 T10829 arg3Of ),(
R8992 T10834 T10836 arg1Of ",",(
R8993 T10834 T10841 arg1Of ",",and
R8994 T10835 T10834 arg2Of APC-anti-PDCA-1,","
R8995 T10837 T10836 arg2Of 927,(
R8996 T10837 T10838 arg1Of 927,","
R8997 T10839 T10838 arg2Of BioLegend,","
R8998 T10840 T10836 arg3Of ),(
R8999 T10841 T10827 arg2Of and,with
R9000 T10842 T10841 arg2Of FITC-anti-CD8α,and
R9001 T10842 T10843 arg1Of FITC-anti-CD8α,(
R9002 T10844 T10843 arg2Of 53–6.7,(
R9003 T10844 T10845 arg1Of 53–6.7,","
R9004 T10847 T10845 arg2Of BioScience,","
R9005 T10847 T10846 arg1Of BioScience,BD
R9006 T10848 T10843 arg3Of ),(
R9007 T10850 T10849 arg1Of cells,The
R9008 T10850 T10851 arg1Of cells,were
R9009 T10850 T10852 arg2Of cells,washed
R9010 T10850 T10855 arg2Of cells,fixed
R9011 T10850 T10862 arg1Of cells,stored
R9012 T10852 T10853 arg1Of washed,twice
R9013 T10852 T10854 arg1Of washed,","
R9014 T10854 T10851 arg2Of ",",were
R9015 T10854 T10861 arg1Of ",",and
R9016 T10855 T10854 arg2Of fixed,","
R9017 T10855 T10856 arg1Of fixed,in
R9018 T10857 T10858 arg1Of 2,%
R9019 T10859 T10856 arg2Of paraformaldehyde,in
R9020 T10859 T10857 arg1Of paraformaldehyde,2
R9021 T10861 T10860 arg1Of and,","
R9022 T10862 T10861 arg2Of stored,and
R9023 T10862 T10863 arg1Of stored,at
R9024 T10862 T10865 arg1Of stored,until
R9025 T10864 T10863 arg2Of 4°C,at
R9026 T10866 T10865 arg2Of analysis,until
R9027 T10868 T10867 arg1Of cytometry,Flow
R9028 T10868 T10869 arg1Of cytometry,was
R9029 T10868 T10870 arg2Of cytometry,performed
R9030 T10870 T10869 arg2Of performed,was
R9031 T10870 T10871 arg1Of performed,in
R9032 T10875 T10874 arg2Of Coulter,(
R9033 T10876 T10874 arg3Of ),(
R9034 T10877 T10871 arg2Of instrument,in
R9035 T10877 T10872 arg1Of instrument,an
R9036 T10877 T10873 arg1Of instrument,Excel
R9037 T10877 T10874 arg1Of instrument,(
R9038 T10879 T10878 arg1Of cells,Dead
R9039 T10879 T10880 arg1Of cells,were
R9040 T10879 T10881 arg2Of cells,omitted
R9041 T10879 T10886 arg1Of cells,gating
R9042 T10881 T10880 arg2Of omitted,were
R9043 T10881 T10882 arg1Of omitted,from
R9044 T10881 T10885 arg1Of omitted,by
R9045 T10881 T10894 arg1Of omitted,and
R9046 T10884 T10882 arg2Of analysis,from
R9047 T10884 T10883 arg1Of analysis,the
R9048 T10886 T10885 arg2Of gating,by
R9049 T10886 T10887 arg1Of gating,on
R9050 T10888 T10889 arg1Of forward,and
R9051 T10889 T10891 arg1Of and,light
R9052 T10890 T10889 arg2Of 90°,and
R9053 T10892 T10887 arg2Of scatter,on
R9054 T10892 T10888 arg1Of scatter,forward
R9055 T10892 T10890 arg1Of scatter,90°
R9056 T10894 T10893 arg1Of and,","
R9057 T10896 T10895 arg1Of cells,"10,000"
R9058 T10896 T10897 arg1Of cells,were
R9059 T10896 T10898 arg2Of cells,analyzed
R9060 T10898 T10894 arg2Of analyzed,and
R9061 T10898 T10897 arg2Of analyzed,were
R9062 T10901 T10898 arg1Of software,analyzed
R9063 T10901 T10899 arg2Of software,by
R9064 T10901 T10900 arg1Of software,FlowJo
R9225 T11114 T11113 arg1Of vitro,in
R9226 T11115 T11111 arg1Of interaction,BMDC-T
R9227 T11115 T11112 arg1Of interaction,cell
R9228 T11115 T11114 arg1Of interaction,vitro
R9229 T11116 T11117 arg1Of WT,and
R9230 T11118 T11117 arg2Of cpdm,and
R9231 T11119 T11116 arg1Of BMDC,WT
R9232 T11119 T11118 arg1Of BMDC,cpdm
R9233 T11119 T11120 arg1Of BMDC,(
R9234 T11119 T11123 arg1Of BMDC,were
R9235 T11119 T11124 arg2Of BMDC,stimulated
R9236 T11121 T11120 arg2Of 5×104,(
R9237 T11122 T11120 arg3Of ),(
R9238 T11124 T11123 arg2Of stimulated,were
R9239 T11124 T11125 arg1Of stimulated,with
R9240 T11126 T11127 arg1Of medium,","
R9241 T11127 T11131 arg1Of ",",","
R9242 T11130 T11127 arg2Of LPS,","
R9243 T11130 T11128 arg1Of LPS,1
R9244 T11130 T11129 arg1Of LPS,µg/mL
R9245 T11131 T11134 arg1Of ",",and
R9246 T11133 T11131 arg2Of µg/mL,","
R9247 T11133 T11132 arg1Of µg/mL,25
R9248 T11134 T11125 arg2Of and,with
R9249 T11137 T11134 arg2Of Pam3CYS,and
R9250 T11137 T11135 arg1Of Pam3CYS,5
R9251 T11137 T11136 arg1Of Pam3CYS,µg/mL
R9252 T11139 T11138 arg1Of hours,24
R9253 T11140 T11139 arg1Of later,hours
R9254 T11142 T11143 arg1Of cells,were
R9255 T11142 T11144 arg2Of cells,collected
R9256 T11142 T11146 arg2Of cells,washed
R9257 T11144 T11145 arg1Of collected,and
R9258 T11145 T11140 arg1Of and,later
R9259 T11145 T11141 arg1Of and,","
R9260 T11145 T11143 arg2Of and,were
R9261 T11146 T11145 arg2Of washed,and
R9262 T11146 T11147 arg1Of washed,with
R9263 T11148 T11147 arg2Of PBS,with
R9264 T11153 T11149 arg1Of cells,Allogeneic
R9265 T11153 T11150 arg1Of cells,naïve
R9266 T11153 T11151 arg1Of cells,CD4+
R9267 T11153 T11152 arg1Of cells,T
R9268 T11153 T11154 arg1Of cells,were
R9269 T11153 T11155 arg2Of cells,isolated
R9270 T11153 T11169 arg1Of cells,were
R9271 T11153 T11171 arg2Of cells,added
R9272 T11153 T11175 arg2Of cells,co-cultured
R9273 T11155 T11154 arg2Of isolated,were
R9274 T11155 T11156 arg1Of isolated,from
R9275 T11155 T11168 arg1Of isolated,and
R9276 T11157 T11156 arg2Of spleens,from
R9277 T11157 T11158 arg1Of spleens,of
R9278 T11157 T11161 arg1Of spleens,by
R9279 T11160 T11158 arg2Of mice,of
R9280 T11160 T11159 arg1Of mice,BALB/c
R9281 T11164 T11161 arg2Of kit,by
R9282 T11164 T11162 arg1Of kit,negative
R9283 T11164 T11163 arg1Of kit,selection
R9284 T11164 T11165 arg1Of kit,(
R9285 T11166 T11165 arg2Of Invitrogen,(
R9286 T11167 T11165 arg3Of ),(
R9287 T11171 T11172 arg1Of added,at
R9288 T11171 T11174 arg1Of added,and
R9289 T11173 T11172 arg2Of 2.5×105,at
R9290 T11174 T11168 arg2Of and,and
R9291 T11174 T11169 arg2Of and,were
R9292 T11174 T11170 arg1Of and,then
R9293 T11175 T11174 arg2Of co-cultured,and
R9294 T11175 T11176 arg1Of co-cultured,with
R9295 T11178 T11176 arg2Of BMDC,with
R9296 T11178 T11177 arg2Of BMDC,activated
R9297 T11181 T11179 arg2Of days,After
R9298 T11181 T11180 arg1Of days,5
R9299 T11183 T11184 arg1Of supernatant,was
R9300 T11183 T11185 arg2Of supernatant,collected
R9301 T11185 T11184 arg2Of collected,was
R9302 T11185 T11186 arg1Of collected,and
R9303 T11186 T11179 arg1Of and,After
R9304 T11186 T11182 arg1Of and,","
R9305 T11188 T11187 arg1Of secretion,the
R9306 T11188 T11189 arg1Of secretion,of
R9307 T11188 T11198 arg2Of secretion,measured
R9308 T11190 T11191 arg1Of IFNγ,","
R9309 T11191 T11193 arg1Of ",",","
R9310 T11192 T11191 arg2Of IL4,","
R9311 T11193 T11196 arg1Of ",",and
R9312 T11194 T11193 arg2Of IL2,","
R9313 T11196 T11189 arg2Of and,of
R9314 T11196 T11195 arg1Of and,","
R9315 T11197 T11196 arg2Of IL17A,and
R9316 T11198 T11186 arg2Of measured,and
R9317 T11200 T11198 arg1Of ELISA,measured
R9318 T11200 T11199 arg2Of ELISA,by
R9319 T11202 T11201 arg1Of controls,Negative
R9320 T11202 T11203 arg1Of controls,are
R9321 T11204 T11206 arg1Of 1,stimulated
R9322 T11206 T11203 arg2Of stimulated,are
R9323 T11206 T11205 arg1Of stimulated,)
R9324 T11206 T11208 arg1Of stimulated,without
R9325 T11207 T11206 arg2Of BMDC,stimulated
R9326 T11209 T11208 arg2Of co-culture,without
R9327 T11209 T11210 arg1Of co-culture,with
R9328 T11214 T11211 arg1Of cells,allogeneic
R9329 T11214 T11212 arg1Of cells,CD4+
R9330 T11214 T11213 arg1Of cells,T
R9331 T11214 T11215 arg1Of cells,;
R9332 T11215 T11210 arg2Of ;,with
R9333 T11216 T11217 arg1Of 2,)
R9334 T11221 T11215 arg2Of cells,;
R9335 T11221 T11216 arg1Of cells,2
R9336 T11221 T11218 arg1Of cells,allogeneic
R9337 T11221 T11219 arg1Of cells,CD4+
R9338 T11221 T11220 arg1Of cells,T
R9339 T11221 T11222 arg1Of cells,without
R9340 T11223 T11222 arg2Of co-culture,without
R9341 T11223 T11224 arg1Of co-culture,with
R9342 T11226 T11224 arg2Of BMDC,with
R9343 T11226 T11225 arg2Of BMDC,stimulated
R9344 T11229 T11227 arg1Of controls,Both
R9345 T11229 T11228 arg1Of controls,negative
R9346 T11229 T11230 arg1Of controls,show
R9347 T11232 T11230 arg2Of production,show
R9348 T11232 T11231 arg1Of production,no
R9349 T11232 T11233 arg1Of production,of
R9350 T11235 T11233 arg2Of cytokines,of
R9351 T11235 T11234 arg1Of cytokines,aforementioned
R9640 T11603 T11602 arg1Of expression,RNA
R9641 T11603 T11604 arg1Of expression,by
R9642 T11605 T11604 arg2Of BMDC,by
R9643 T11606 T11607 arg1Of BMDC,were
R9644 T11606 T11608 arg2Of BMDC,cultured
R9645 T11608 T11607 arg2Of cultured,were
R9646 T11608 T11609 arg1Of cultured,at
R9647 T11608 T11612 arg1Of cultured,in
R9648 T11608 T11619 arg1Of cultured,in
R9649 T11608 T11635 arg1Of cultured,After
R9650 T11611 T11609 arg2Of cells/mL,at
R9651 T11611 T11610 arg1Of cells/mL,106
R9652 T11614 T11612 arg2Of mL,in
R9653 T11614 T11613 arg1Of mL,10
R9654 T11614 T11615 arg1Of mL,of
R9655 T11618 T11615 arg2Of medium,of
R9656 T11618 T11616 arg1Of medium,RPMI-1640
R9657 T11618 T11617 arg1Of medium,complete
R9658 T11621 T11622 arg1Of presence,or
R9659 T11622 T11619 arg2Of or,in
R9660 T11622 T11620 arg1Of or,the
R9661 T11622 T11624 arg1Of or,of
R9662 T11622 T11633 arg1Of or,:
R9663 T11623 T11622 arg2Of absence,or
R9664 T11625 T11626 arg1Of 100,ng/mL
R9665 T11627 T11625 arg1Of LPS,100
R9666 T11627 T11628 arg1Of LPS,or
R9667 T11628 T11624 arg2Of or,of
R9668 T11631 T11628 arg2Of poly,or
R9669 T11631 T11629 arg1Of poly,25
R9670 T11631 T11630 arg1Of poly,µg/mL
R9671 T11631 T11632 arg1Of poly,I
R9672 T11634 T11633 arg2Of C.,:
R9673 T11636 T11637 arg1Of 1,and
R9674 T11638 T11637 arg2Of 2,and
R9675 T11639 T11635 arg2Of hours,After
R9676 T11639 T11636 arg1Of hours,1
R9677 T11639 T11638 arg1Of hours,2
R9678 T11641 T11642 arg1Of RNA,was
R9679 T11641 T11643 arg2Of RNA,isolated
R9680 T11643 T11607 modOf isolated,were
R9681 T11643 T11640 arg1Of isolated,","
R9682 T11643 T11642 arg2Of isolated,was
R9683 T11643 T11644 arg1Of isolated,with
R9684 T11643 T11649 arg1Of isolated,according
R9685 T11645 T11644 arg2Of TRI-reagent,with
R9686 T11645 T11646 arg1Of TRI-reagent,(
R9687 T11647 T11646 arg2Of Sigma,(
R9688 T11648 T11646 arg3Of ),(
R9689 T11650 T11649 arg2Of to,according
R9690 T11652 T11651 arg1Of manufacturer,the
R9691 T11652 T11653 arg2Of manufacturer,'s
R9692 T11654 T11650 arg2Of instructions,to
R9693 T11654 T11653 arg1Of instructions,'s
R9694 T11656 T11655 arg1Of expression,The
R9695 T11656 T11657 arg1Of expression,of
R9696 T11656 T11667 arg1Of expression,was
R9697 T11656 T11668 arg2Of expression,determined
R9698 T11658 T11659 arg1Of Il6,","
R9699 T11659 T11661 arg1Of ",",","
R9700 T11660 T11659 arg2Of Il12p40,","
R9701 T11661 T11664 arg1Of ",",and
R9702 T11662 T11661 arg2Of Gmcsf,","
R9703 T11664 T11657 arg2Of and,of
R9704 T11664 T11663 arg1Of and,","
R9705 T11666 T11664 arg2Of mRNA,and
R9706 T11666 T11665 arg1Of mRNA,Sharpin
R9707 T11668 T11667 arg2Of determined,was
R9708 T11670 T11668 arg1Of qRT-PCR,determined
R9709 T11670 T11669 arg2Of qRT-PCR,by
R9710 T11671 T11672 arg1Of Primers,and
R9711 T11672 T11674 arg1Of and,were
R9712 T11672 T11675 arg2Of and,purchased
R9713 T11673 T11672 arg2Of probes,and
R9714 T11675 T11674 arg2Of purchased,were
R9715 T11675 T11676 arg1Of purchased,from
R9716 T11675 T11721 arg1Of purchased,and
R9717 T11679 T11677 arg1Of Reverse,Applied
R9718 T11679 T11678 arg1Of Reverse,Biosystems.
R9719 T11679 T11701 arg1Of Reverse,containing
R9720 T11680 T11681 arg1Of transcription,was
R9721 T11680 T11682 arg2Of transcription,performed
R9722 T11682 T11681 arg2Of performed,was
R9723 T11682 T11683 arg1Of performed,at
R9724 T11682 T11685 arg1Of performed,for
R9725 T11682 T11688 arg1Of performed,with
R9726 T11684 T11683 arg2Of 42°C,at
R9727 T11687 T11685 arg2Of minutes,for
R9728 T11687 T11686 arg1Of minutes,60
R9729 T11692 T11688 arg2Of step,with
R9730 T11692 T11689 arg1Of step,the
R9731 T11692 T11690 arg1Of step,final
R9732 T11692 T11691 arg1Of step,denaturation
R9733 T11692 T11693 arg1Of step,at
R9734 T11692 T11695 arg1Of step,for
R9735 T11692 T11698 arg1Of step,in
R9736 T11694 T11693 arg2Of 90°C,at
R9737 T11697 T11695 arg2Of minutes,for
R9738 T11697 T11696 arg1Of minutes,5
R9739 T11700 T11698 arg2Of µl,in
R9740 T11700 T11699 arg1Of µl,30
R9741 T11701 T11681 modOf containing,was
R9742 T11703 T11701 arg2Of µg,containing
R9743 T11703 T11702 arg1Of µg,0.5
R9744 T11703 T11704 arg1Of µg,of
R9745 T11707 T11704 arg2Of dNTPs,of
R9746 T11707 T11705 arg1Of dNTPs,total
R9747 T11707 T11706 arg1Of dNTPs,RNA.
R9748 T11707 T11708 arg1Of dNTPs,","
R9749 T11709 T11708 arg2Of oligo,","
R9750 T11709 T11710 arg1Of oligo,(
R9751 T11711 T11710 arg2Of dT,(
R9752 T11712 T11710 arg3Of ),(
R9753 T11714 T11676 arg2Of primer,from
R9754 T11714 T11679 arg1Of primer,Reverse
R9755 T11714 T11713 arg1Of primer,15
R9756 T11714 T11715 arg1Of primer,","
R9757 T11719 T11715 arg2Of Inhibitor,","
R9758 T11719 T11716 arg1Of Inhibitor,recombinant
R9759 T11719 T11717 arg1Of Inhibitor,RNasin
R9760 T11719 T11718 arg1Of Inhibitor,Ribonuclease
R9761 T11721 T11720 arg1Of and,","
R9762 T11724 T11722 arg1Of Transcriptase,M-MLV
R9763 T11724 T11723 arg1Of Transcriptase,Reverse
R9764 T11724 T11725 arg1Of Transcriptase,(
R9765 T11724 T11734 arg1Of Transcriptase,were
R9766 T11724 T11735 arg2Of Transcriptase,used
R9767 T11726 T11725 arg2Of all,(
R9768 T11726 T11727 arg1Of all,from
R9769 T11726 T11729 arg1Of all,","
R9770 T11728 T11727 arg2Of Promega,from
R9771 T11730 T11729 arg2Of Madison,","
R9772 T11730 T11731 arg1Of Madison,","
R9773 T11732 T11731 arg2Of WI,","
R9774 T11733 T11725 arg3Of ),(
R9775 T11735 T11721 arg2Of used,and
R9776 T11735 T11734 arg2Of used,were
R9777 T11735 T11736 arg1Of used,according
R9778 T11737 T11736 arg2Of to,according
R9779 T11739 T11738 arg1Of manufacturer,the
R9780 T11739 T11740 arg2Of manufacturer,'s
R9781 T11741 T11737 arg2Of instruction,to
R9782 T11741 T11740 arg1Of instruction,'s
R9783 T11743 T11742 arg1Of transcription,Reverse
R9784 T11743 T11744 arg1Of transcription,was
R9785 T11743 T11745 arg2Of transcription,done
R9786 T11745 T11744 arg2Of done,was
R9787 T11745 T11746 arg1Of done,in
R9788 T11751 T11746 arg2Of Cycler,in
R9789 T11751 T11747 arg1Of Cycler,a
R9790 T11751 T11748 arg1Of Cycler,PTC-200
R9791 T11751 T11749 arg1Of Cycler,Peltier
R9792 T11751 T11750 arg1Of Cycler,Thermal
R9793 T11751 T11752 arg1Of Cycler,(
R9794 T11754 T11753 arg1Of Research,MJ
R9795 T11754 T11755 arg1Of Research,","
R9796 T11755 T11752 arg2Of ",",(
R9797 T11755 T11757 arg1Of ",",","
R9798 T11755 T11758 arg1Of ",",MA
R9799 T11756 T11755 arg2Of Watertown,","
R9800 T11759 T11752 arg3Of ),(
R9801 T11760 T11761 arg1Of . qRT-P,CR
R9802 T11760 T11762 arg2Of . qRT-P,was perfo
R9803 T11762 T11744 modOf was perfo,was
R9804 T11762 T11761 arg2Of was perfo,CR
R9805 T11762 T11763 arg1Of was perfo,rm
R9806 T11762 T11798 arg1Of was perfo,", Ifnβ, G"
R9807 T11769 T11763 arg2Of Detect,rm
R9808 T11769 T11764 arg1Of Detect,ed
R9809 T11769 T11765 arg1Of Detect,in AB
R9810 T11769 T11766 arg1Of Detect,I Pr
R9811 T11769 T11767 arg1Of Detect,ism 7700
R9812 T11769 T11768 arg1Of Detect,Sequence
R9813 T11769 T11770 arg1Of Detect,ion
R9814 T11769 T11784 arg1Of Detect,"s, "
R9815 T11772 T11771 arg1Of with,System
R9816 T11774 T11770 arg2Of ne Exp,ion
R9817 T11774 T11772 arg1Of ne Exp,with
R9818 T11774 T11773 arg1Of ne Exp,TaqMan® Ge
R9819 T11774 T11775 arg1Of ne Exp,r
R9820 T11777 T11775 arg2Of Assays (Ap,r
R9821 T11777 T11776 arg1Of Assays (Ap,ession
R9822 T11777 T11778 arg1Of Assays (Ap,p
R9823 T11780 T11778 arg2Of iosy,p
R9824 T11780 T11779 arg1Of iosy,lied B
R9825 T11780 T11781 arg1Of iosy,s
R9826 T11782 T11781 arg2Of te,s
R9827 T11783 T11775 arg3Of m,r
R9828 T11786 T11785 arg1Of r Ci,Foste
R9829 T11786 T11787 arg1Of r Ci,t
R9830 T11787 T11789 arg1Of t,C
R9831 T11788 T11787 arg2Of "y, ",t
R9832 T11789 T11791 arg1Of C,m
R9833 T11790 T11789 arg2Of A) for ,C
R9834 T11791 T11793 arg1Of m,A
R9835 T11792 T11791 arg2Of ouse,m
R9836 T11793 T11796 arg1Of A,"L6,"
R9837 T11794 T11793 arg2Of "ctb, ",A
R9838 T11796 T11784 arg2Of "L6,","s, "
R9839 T11796 T11795 arg1Of "L6,",I
R9840 T11797 T11796 arg2Of IL12p40,"L6,"
R9841 T11799 T11798 arg2Of mc,", Ifnβ, G"
R9842 T11801 T11800 arg1Of and Sharpin ,"sf,"
R9843 T11801 T11802 arg2Of and Sharpin ,ac
R9844 T11803 T11799 arg2Of cording ,mc
R9845 T11803 T11802 arg1Of cording ,ac
R9846 T11806 T11804 arg1Of standard,The
R9847 T11806 T11805 arg1Of standard,endogenous
R9848 T11806 T11807 arg1Of standard,for
R9849 T11806 T11813 arg1Of standard,was
R9850 T11806 T11814 arg1Of standard,β-actin
R9851 T11808 T11807 arg2Of normalization,for
R9852 T11808 T11809 arg1Of normalization,of
R9853 T11812 T11809 arg2Of gene,of
R9854 T11812 T11810 arg1Of gene,the
R9855 T11812 T11811 arg1Of gene,target
R9856 T11814 T11813 arg2Of β-actin,was
R9857 T11817 T11815 arg1Of expression,Relative
R9858 T11817 T11816 arg1Of expression,gene
R9859 T11817 T11818 arg1Of expression,was
R9860 T11817 T11819 arg2Of expression,calculated
R9861 T11819 T11818 arg2Of calculated,was
R9862 T11819 T11820 modOf calculated,using
R9863 T11820 T11824 arg1Of using,[
R9864 T11823 T11820 arg2Of method,using
R9865 T11823 T11821 arg1Of method,the
R9866 T11823 T11822 arg1Of method,2−ΔΔCt
R9867 T11825 T11824 arg2Of 56,[
R9868 T11826 T11824 arg3Of ],[
R9960 T12002 T12001 arg1Of vitro,In
R9961 T12004 T12002 arg1Of secretion,vitro
R9962 T12004 T12003 arg1Of secretion,cytokine
R9963 T12004 T12005 arg1Of secretion,by
R9964 T12006 T12005 arg2Of BMDC,by
R9965 T12008 T12007 arg1Of BMDC,The
R9966 T12008 T12009 arg1Of BMDC,were
R9967 T12008 T12010 arg2Of BMDC,cultured
R9968 T12010 T12009 arg2Of cultured,were
R9969 T12010 T12011 arg1Of cultured,in
R9970 T12010 T12024 arg1Of cultured,","
R9971 T12010 T12025 arg1Of cultured,respectively
R9972 T12010 T12026 arg1Of cultured,","
R9973 T12010 T12027 arg1Of cultured,in
R9974 T12013 T12011 arg2Of wells,in
R9975 T12013 T12012 arg1Of wells,triplicate
R9976 T12013 T12014 arg1Of wells,of
R9977 T12015 T12016 arg1Of 24-well,or
R9978 T12017 T12016 arg2Of 96-well,or
R9979 T12018 T12014 arg2Of plates,of
R9980 T12018 T12015 arg1Of plates,24-well
R9981 T12018 T12017 arg1Of plates,96-well
R9982 T12018 T12019 arg1Of plates,at
R9983 T12020 T12021 arg1Of 106,or
R9984 T12022 T12021 arg2Of 105,or
R9985 T12023 T12019 arg2Of cells/mL,at
R9986 T12023 T12020 arg1Of cells/mL,106
R9987 T12023 T12022 arg1Of cells/mL,105
R9988 T12030 T12027 arg2Of medium,in
R9989 T12030 T12028 arg1Of medium,RPMI-1640
R9990 T12030 T12029 arg1Of medium,complete
R9991 T12032 T12031 arg1Of cells,The
R9992 T12032 T12033 arg1Of cells,were
R9993 T12032 T12034 arg2Of cells,washed
R9994 T12032 T12036 arg2Of cells,stimulated
R9995 T12034 T12035 arg1Of washed,and
R9996 T12035 T12033 arg2Of and,were
R9997 T12035 T12048 arg1Of and,After
R9998 T12035 T12051 arg1Of and,","
R9999 T12036 T12035 arg2Of stimulated,and