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PMC:3218875 JSONTXT 30 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T5 0-8 JJ denotes Negative
T6 9-19 NN denotes regulation
T7 20-22 IN denotes of
T8 23-28 NN denotes NF-κB
T9 29-32 CC denotes and
T10 33-36 PRP-DOLLAR- denotes its
T11 37-48 NN denotes involvement
T12 49-51 IN denotes in
T13 52-62 JJ denotes rheumatoid
T14 63-72 NN denotes arthritis
T15 83-86 DT denotes The
T16 87-100 NN denotes transcription
T17 101-107 NN denotes factor
T18 108-113 NN denotes NF-κB
T19 114-119 VB denotes plays
T20 120-127 JJ denotes crucial
T21 128-133 NN denotes roles
T22 134-136 IN denotes in
T23 137-140 DT denotes the
T24 141-151 NN denotes regulation
T25 152-154 IN denotes of
T26 155-167 NN denotes inflammation
T27 168-171 CC denotes and
T28 172-177 JJ denotes mmune
T29 178-187 NN denotes responses
T30 187-188 -COMMA- denotes ,
T31 189-192 CC denotes and
T32 193-206 JJ denotes inappropriate
T33 207-212 NN denotes NF-κB
T34 213-221 NN denotes activity
T35 222-225 VB denotes has
T36 226-230 VB denotes been
T37 231-237 VB denotes linked
T38 238-242 IN denotes with
T39 243-247 JJ denotes many
T40 248-258 JJ denotes autoimmune
T41 259-262 CC denotes and
T42 263-275 JJ denotes inflammatory
T43 276-284 NN denotes diseases
T44 284-285 -COMMA- denotes ,
T45 286-295 VB denotes including
T46 296-306 JJ denotes rheumatoid
T47 307-316 NN denotes arthritis
T48 318-323 NN denotes Cells
T49 324-330 VB denotes employ
T50 331-332 DT denotes a
T51 333-345 JJ denotes multilayered
T52 346-353 NN denotes control
T53 354-360 NN denotes system
T54 361-363 TO denotes to
T55 364-368 VB denotes keep
T56 369-374 NN denotes NF-κB
T57 375-385 NN denotes signalling
T58 386-388 IN denotes in
T59 389-394 NN denotes check
T60 394-395 -COMMA- denotes ,
T61 396-405 VB denotes including
T62 406-407 DT denotes a
T63 408-418 NN denotes repertoire
T64 419-421 IN denotes of
T65 422-430 JJ denotes negative
T66 431-439 NN denotes feedback
T67 440-450 NN denotes regulators
T68 451-459 VB denotes ensuring
T69 460-471 NN denotes termination
T70 472-474 IN denotes of
T71 475-480 NN denotes NF-κB
T72 481-490 NN denotes responses
T73 492-496 RB denotes Here
T74 497-499 PRP denotes we
T75 500-504 MD denotes will
T76 505-511 VB denotes review
T77 512-519 JJ denotes various
T78 520-528 JJ denotes negative
T79 529-539 JJ denotes regulatory
T80 540-550 NN denotes mechanisms
T81 551-555 WDT denotes that
T82 556-560 VB denotes have
T83 561-568 VB denotes evolved
T84 569-571 TO denotes to
T85 572-579 VB denotes control
T86 580-585 NN denotes NF-κB
T87 586-596 NN denotes signalling
T88 597-600 CC denotes and
T89 601-606 WDT denotes which
T90 607-611 VB denotes have
T91 612-616 VB denotes been
T92 617-627 VB denotes implicated
T93 628-630 IN denotes in
T94 631-634 DT denotes the
T95 635-647 NN denotes pathogenesis
T96 648-650 IN denotes of
T97 651-661 JJ denotes rheumatoid
T98 662-671 NN denotes arthritis
T374 687-697 JJ denotes Rheumatoid
T375 698-707 NN denotes arthritis
T376 708-709 -LRB- denotes (
T377 709-711 NN denotes RA
T378 711-712 -RRB- denotes )
T379 713-715 VB denotes is
T380 716-719 DT denotes the
T381 720-724 RB denotes most
T382 725-731 JJ denotes common
T383 732-744 JJ denotes inflammatory
T384 745-754 NN denotes arthritis
T385 754-755 -COMMA- denotes ,
T386 756-765 VB denotes affecting
T387 766-768 IN denotes up
T388 769-771 TO denotes to
T389 772-773 CD denotes 1
T390 773-774 NN denotes %
T391 775-777 IN denotes of
T392 778-781 DT denotes the
T393 782-787 JJ denotes adult
T394 788-798 NN denotes population
T395 800-802 NN denotes RA
T396 803-805 VB denotes is
T397 806-819 VB denotes characterised
T398 820-822 IN denotes by
T399 823-824 DT denotes a
T400 825-836 JJ denotes symmetrical
T401 837-850 NN denotes polyarthritis
T402 851-853 IN denotes in
T403 854-859 WDT denotes which
T404 860-867 JJ denotes chronic
T405 868-880 NN denotes inflammation
T406 881-883 IN denotes of
T407 884-890 NN denotes joints
T408 891-893 VB denotes is
T409 894-904 VB denotes associated
T410 905-909 IN denotes with
T411 910-911 DT denotes a
T412 912-923 JJ denotes progressive
T413 924-935 NN denotes destruction
T414 936-938 IN denotes of
T415 939-948 NN denotes cartilage
T416 949-952 CC denotes and
T417 953-957 NN denotes bone
T418 957-958 -COMMA- denotes ,
T419 959-966 VB denotes leading
T420 967-969 TO denotes to
T421 970-980 JJ denotes functional
T422 981-988 NN denotes decline
T423 989-992 CC denotes and
T424 993-1003 NN denotes disability
T425 1005-1017 NN denotes Infiltration
T426 1018-1020 IN denotes of
T427 1021-1026 NN denotes cells
T428 1027-1029 IN denotes of
T429 1030-1033 DT denotes the
T430 1034-1040 JJ denotes innate
T431 1041-1044 CC denotes and
T432 1045-1053 JJ denotes adaptive
T433 1054-1060 JJ denotes immune
T434 1061-1067 NN denotes system
T435 1068-1072 IN denotes into
T436 1073-1076 DT denotes the
T437 1077-1082 JJ denotes joint
T438 1083-1088 NN denotes space
T439 1089-1095 VB denotes drives
T440 1096-1099 DT denotes the
T441 1100-1105 JJ denotes local
T442 1106-1116 NN denotes production
T443 1117-1119 IN denotes of
T444 1120-1135 JJ denotes proinflammatory
T445 1136-1144 NN denotes T-helper
T446 1145-1149 NN denotes type
T447 1150-1151 CD denotes 1
T448 1152-1155 CC denotes and
T449 1156-1164 NN denotes T-helper
T450 1165-1169 NN denotes type
T451 1170-1172 CD denotes 17
T452 1173-1182 NN denotes cytokines
T453 1182-1183 -COMMA- denotes ,
T454 1184-1194 NN denotes chemokines
T455 1194-1195 -COMMA- denotes ,
T456 1196-1199 CC denotes and
T457 1200-1206 NN denotes matrix
T458 1207-1225 NN denotes metalloproteinases
T459 1226-1228 IN denotes by
T460 1229-1241 VB denotes infiltrating
T461 1242-1251 NN denotes monocytes
T462 1252-1255 CC denotes and
T463 1256-1264 JJ denotes synovial
T464 1265-1270 NN denotes cells
T465 1272-1285 NN denotes Proliferation
T466 1286-1288 IN denotes of
T467 1289-1297 JJ denotes synovial
T468 1298-1309 NN denotes fibroblasts
T469 1310-1315 VB denotes leads
T470 1316-1318 TO denotes to
T471 1319-1322 DT denotes the
T472 1323-1332 NN denotes formation
T473 1333-1335 IN denotes of
T474 1336-1342 NN denotes pannus
T475 1343-1349 NN denotes tissue
T476 1349-1350 -COMMA- denotes ,
T477 1351-1356 WDT denotes which
T478 1357-1364 VB denotes invades
T479 1365-1368 CC denotes and
T480 1369-1377 VB denotes degrades
T481 1378-1387 JJ denotes articular
T482 1388-1397 NN denotes cartilage
T483 1398-1401 CC denotes and
T484 1402-1413 JJ denotes subchondral
T485 1414-1418 NN denotes bone
T486 1420-1423 DT denotes The
T487 1424-1433 NN denotes aetiology
T488 1434-1436 IN denotes of
T489 1437-1439 NN denotes RA
T490 1440-1442 VB denotes is
T491 1443-1448 RB denotes still
T492 1449-1452 RB denotes not
T493 1453-1463 VB denotes understood
T494 1463-1464 -COMMA- denotes ,
T495 1465-1468 CC denotes but
T496 1469-1471 PRP denotes it
T497 1472-1474 VB denotes is
T498 1475-1479 RB denotes well
T499 1480-1488 VB denotes accepted
T500 1489-1493 IN denotes that
T501 1494-1504 NN denotes activation
T502 1505-1507 IN denotes of
T503 1508-1523 JJ denotes NF-κB-dependent
T504 1524-1528 NN denotes gene
T505 1529-1539 NN denotes expression
T506 1540-1545 VB denotes plays
T507 1546-1547 DT denotes a
T508 1548-1551 JJ denotes key
T509 1552-1556 NN denotes role
T510 1557-1559 IN denotes in
T511 1560-1563 DT denotes the
T512 1564-1575 NN denotes development
T513 1576-1578 IN denotes of
T514 1579-1581 NN denotes RA
T515 1582-1585 CC denotes and
T516 1586-1590 JJ denotes many
T517 1591-1596 JJ denotes other
T518 1597-1607 JJ denotes autoimmune
T519 1608-1616 NN denotes diseases
T520 1618-1623 NN denotes NF-κB
T521 1624-1634 VB denotes represents
T522 1635-1636 DT denotes a
T523 1637-1643 NN denotes family
T524 1644-1646 IN denotes of
T525 1647-1659 RB denotes structurally
T526 1660-1667 VB denotes related
T527 1668-1671 CC denotes and
T528 1672-1686 RB denotes evolutionarily
T529 1687-1696 VB denotes conserved
T530 1697-1705 NN denotes proteins
T531 1706-1707 -LRB- denotes (
T532 1707-1711 NN denotes p100
T533 1712-1714 CC denotes or
T534 1715-1721 NN denotes NF-κB2
T535 1721-1722 -COMMA- denotes ,
T536 1723-1727 NN denotes p105
T537 1728-1730 CC denotes or
T538 1731-1737 NN denotes NF-κB1
T539 1737-1738 -COMMA- denotes ,
T540 1739-1742 NN denotes p65
T541 1743-1745 CC denotes or
T542 1746-1750 NN denotes RelA
T543 1750-1751 -COMMA- denotes ,
T544 1752-1756 NN denotes RelB
T545 1756-1757 -COMMA- denotes ,
T546 1758-1763 NN denotes c-Rel
T547 1763-1764 -RRB- denotes )
T548 1765-1769 WDT denotes that
T549 1770-1778 VB denotes function
T550 1779-1781 IN denotes as
T551 1782-1792 NN denotes homodimers
T552 1793-1795 CC denotes or
T553 1796-1808 NN denotes heterodimers
T554 1809-1810 -LRB- denotes [
T555 1810-1811 CD denotes 1
T556 1811-1812 -RRB- denotes ]
T557 1812-1813 -COMMA- denotes ,
T558 1814-1817 CC denotes and
T559 1818-1822 WDT denotes that
T560 1823-1831 VB denotes regulate
T561 1832-1835 DT denotes the
T562 1836-1846 NN denotes expression
T563 1847-1849 IN denotes of
T564 1850-1851 DT denotes a
T565 1852-1857 JJ denotes large
T566 1858-1864 NN denotes number
T567 1865-1867 IN denotes of
T568 1868-1873 NN denotes genes
T569 1874-1875 -COLON- denotes -
T570 1876-1880 JJ denotes such
T571 1881-1883 IN denotes as
T572 1884-1887 NN denotes TNF
T573 1887-1888 -COMMA- denotes ,
T574 1889-1893 NN denotes IL-1
T575 1893-1894 -COMMA- denotes ,
T576 1895-1899 NN denotes IL-6
T577 1899-1900 -COMMA- denotes ,
T578 1901-1918 NN denotes cyclo-oxygenase-2
T579 1918-1919 -COMMA- denotes ,
T580 1920-1930 NN denotes chemokines
T581 1930-1931 -COMMA- denotes ,
T582 1932-1941 JJ denotes inducible
T583 1942-1948 JJ denotes nitric
T584 1949-1954 NN denotes oxide
T585 1955-1963 NN denotes synthase
T586 1963-1964 -COMMA- denotes ,
T587 1965-1968 CC denotes and
T588 1969-1975 NN denotes matrix
T589 1976-1994 NN denotes metalloproteinases
T590 1995-1996 -COLON- denotes -
T591 1997-2001 WDT denotes that
T592 2002-2005 VB denotes are
T593 2006-2014 VB denotes involved
T594 2015-2017 IN denotes in
T595 2018-2020 NN denotes RA
T596 2022-2024 IN denotes In
T597 2025-2033 NN denotes addition
T598 2033-2034 -COMMA- denotes ,
T599 2035-2038 NN denotes TNF
T600 2039-2042 CC denotes and
T601 2043-2047 NN denotes IL-1
T602 2048-2051 VB denotes are
T603 2052-2062 PRP denotes themselves
T604 2063-2067 RB denotes very
T605 2068-2074 JJ denotes potent
T606 2075-2085 NN denotes activators
T607 2086-2088 IN denotes of
T608 2089-2094 NN denotes NF-κB
T609 2095-2096 -LRB- denotes (
T610 2096-2104 VB denotes reviewed
T611 2105-2107 IN denotes in
T612 2108-2109 -LRB- denotes [
T613 2109-2112 CD denotes 2,3
T614 2112-2113 -RRB- denotes ]
T615 2113-2114 -RRB- denotes )
T616 2116-2121 NN denotes NF-κB
T617 2122-2132 NN denotes activation
T618 2133-2136 MD denotes can
T619 2137-2139 VB denotes be
T620 2140-2148 VB denotes detected
T621 2149-2151 IN denotes in
T622 2152-2160 VB denotes cultured
T623 2161-2169 JJ denotes synovial
T624 2170-2181 NN denotes fibroblasts
T625 2182-2185 CC denotes and
T626 2186-2194 JJ denotes synovial
T627 2195-2201 NN denotes tissue
T628 2202-2206 IN denotes from
T629 2207-2209 NN denotes RA
T630 2210-2218 NN denotes patients
T631 2218-2219 -COMMA- denotes ,
T632 2220-2223 CC denotes and
T633 2224-2230 NN denotes animal
T634 2231-2237 NN denotes models
T635 2238-2240 IN denotes of
T636 2241-2253 JJ denotes inflammatory
T637 2254-2263 NN denotes arthritis
T638 2264-2268 RB denotes also
T639 2269-2280 VB denotes demonstrate
T640 2281-2284 DT denotes the
T641 2285-2291 JJ denotes active
T642 2292-2296 NN denotes role
T643 2297-2299 IN denotes of
T644 2300-2305 NN denotes NF-κB
T645 2306-2308 IN denotes in
T646 2309-2312 DT denotes the
T647 2313-2324 NN denotes development
T648 2325-2328 CC denotes and
T649 2329-2340 NN denotes progression
T650 2341-2343 IN denotes of
T651 2344-2346 NN denotes RA
T652 2347-2348 -LRB- denotes (
T653 2348-2356 VB denotes reviewed
T654 2357-2359 IN denotes in
T655 2360-2361 -LRB- denotes [
T656 2361-2362 CD denotes 4
T657 2362-2363 -RRB- denotes ]
T658 2363-2364 -RRB- denotes )
T659 2366-2369 DT denotes The
T660 2370-2374 NN denotes time
T661 2375-2381 NN denotes course
T662 2382-2384 IN denotes of
T663 2385-2390 NN denotes NF-κB
T664 2391-2401 NN denotes activation
T665 2402-2409 VB denotes appears
T666 2410-2412 TO denotes to
T667 2413-2420 VB denotes precede
T668 2421-2424 DT denotes the
T669 2425-2430 NN denotes onset
T670 2431-2433 IN denotes of
T671 2434-2441 NN denotes disease
T672 2441-2442 -COMMA- denotes ,
T673 2443-2446 CC denotes and
T674 2447-2455 NN denotes blockade
T675 2456-2458 IN denotes of
T676 2459-2464 NN denotes NF-κB
T677 2465-2467 IN denotes by
T678 2468-2477 JJ denotes different
T679 2478-2483 NN denotes means
T680 2484-2493 VB denotes decreases
T681 2494-2501 NN denotes disease
T682 2502-2510 NN denotes severity
T683 2511-2512 -LRB- denotes [
T684 2512-2515 CD denotes 5,6
T685 2515-2516 -RRB- denotes ]
T686 2518-2522 JJ denotes Next
T687 2523-2525 TO denotes to
T688 2526-2529 PRP-DOLLAR- denotes its
T689 2530-2534 NN denotes role
T690 2535-2537 IN denotes in
T691 2538-2553 JJ denotes proinflammatory
T692 2554-2558 NN denotes gene
T693 2559-2569 NN denotes expression
T694 2569-2570 -COMMA- denotes ,
T695 2571-2576 NN denotes NF-κB
T696 2577-2579 VB denotes is
T697 2580-2584 RB denotes also
T698 2585-2594 JJ denotes essential
T699 2595-2598 IN denotes for
T700 2599-2617 NN denotes osteoclastogenesis
T701 2617-2618 -COMMA- denotes ,
T702 2619-2625 RB denotes mainly
T703 2626-2628 IN denotes by
T704 2629-2638 VB denotes mediating
T705 2639-2642 DT denotes the
T706 2643-2650 NN denotes effects
T707 2651-2653 IN denotes of
T708 2654-2662 NN denotes receptor
T709 2663-2672 NN denotes activator
T710 2673-2675 IN denotes of
T711 2676-2681 NN denotes NF-κB
T712 2682-2688 NN denotes ligand
T713 2689-2690 -LRB- denotes (
T714 2690-2695 NN denotes RANKL
T715 2695-2696 -RRB- denotes )
T716 2698-2705 NN denotes Defects
T717 2706-2708 IN denotes in
T718 2709-2712 DT denotes the
T719 2713-2723 NN denotes regulation
T720 2724-2726 IN denotes of
T721 2727-2745 NN denotes osteoclastogenesis
T722 2746-2749 VB denotes are
T723 2750-2753 DT denotes the
T724 2754-2759 JJ denotes major
T725 2760-2765 NN denotes cause
T726 2766-2768 IN denotes of
T727 2769-2773 NN denotes bone
T728 2774-2781 NN denotes erosion
T729 2782-2784 IN denotes in
T730 2785-2795 JJ denotes osteolytic
T731 2796-2804 NN denotes diseases
T732 2805-2809 JJ denotes such
T733 2810-2812 IN denotes as
T734 2813-2815 NN denotes RA
T735 2816-2817 -LRB- denotes [
T736 2817-2818 CD denotes 7
T737 2818-2819 -RRB- denotes ]
T738 2821-2828 RB denotes Finally
T739 2828-2829 -COMMA- denotes ,
T740 2830-2836 JJ denotes recent
T741 2837-2848 NN denotes discoveries
T742 2849-2858 VB denotes revealing
T743 2859-2860 DT denotes a
T744 2861-2868 JJ denotes genetic
T745 2869-2880 NN denotes association
T746 2881-2885 IN denotes with
T747 2886-2893 JJ denotes several
T748 2894-2899 NN denotes genes
T749 2900-2908 JJ denotes relevant
T750 2909-2911 TO denotes to
T751 2912-2917 NN denotes NF-κB
T752 2918-2928 NN denotes signalling
T753 2928-2929 -COMMA- denotes ,
T754 2930-2939 VB denotes including
T755 2940-2944 NN denotes CD40
T756 2944-2945 -COMMA- denotes ,
T757 2946-2951 NN denotes TRAF1
T758 2951-2952 -COMMA- denotes ,
T759 2953-2960 NN denotes TNFAIP3
T760 2960-2961 -COMMA- denotes ,
T761 2962-2965 CC denotes and
T762 2966-2971 NN denotes c-REL
T763 2971-2972 -COMMA- denotes ,
T764 2973-2980 RB denotes further
T765 2981-2990 VB denotes highlight
T766 2991-2994 DT denotes the
T767 2995-3005 NN denotes importance
T768 3006-3008 IN denotes of
T769 3009-3014 NN denotes NF-κB
T770 3015-3025 NN denotes activation
T771 3026-3028 IN denotes in
T772 3029-3031 NN denotes RA
T773 3032-3044 NN denotes pathogenesis
T774 3045-3046 -LRB- denotes [
T775 3046-3047 CD denotes 8
T776 3047-3048 -RRB- denotes ]
T1847 3099-3104 IN denotes Since
T1848 3105-3110 NN denotes NF-κB
T1849 3111-3113 VB denotes is
T1850 3114-3121 JJ denotes central
T1851 3122-3124 TO denotes to
T1852 3125-3128 DT denotes the
T1853 3129-3136 NN denotes process
T1854 3137-3139 IN denotes of
T1855 3140-3152 NN denotes inflammation
T1856 3153-3155 IN denotes in
T1857 3156-3158 NN denotes RA
T1858 3158-3159 -COMMA- denotes ,
T1859 3160-3164 JJ denotes much
T1860 3165-3173 NN denotes research
T1861 3174-3179 NN denotes deals
T1862 3180-3184 IN denotes with
T1863 3185-3188 DT denotes the
T1864 3189-3203 NN denotes identification
T1865 3204-3206 IN denotes of
T1866 3207-3210 DT denotes the
T1867 3211-3220 JJ denotes molecular
T1868 3221-3229 NN denotes triggers
T1869 3230-3234 WDT denotes that
T1870 3235-3243 VB denotes activate
T1871 3244-3249 NN denotes NF-κB
T1872 3250-3252 IN denotes in
T1873 3253-3255 NN denotes RA
T1874 3257-3259 PRP denotes It
T1875 3260-3262 VB denotes is
T1876 3263-3267 RB denotes well
T1877 3268-3276 VB denotes accepted
T1878 3277-3281 IN denotes that
T1879 3282-3297 JJ denotes proinflammatory
T1880 3298-3307 NN denotes cytokines
T1881 3308-3312 JJ denotes such
T1882 3313-3315 IN denotes as
T1883 3316-3319 NN denotes TNF
T1884 3320-3323 CC denotes and
T1885 3324-3328 NN denotes IL-1
T1886 3329-3333 VB denotes play
T1887 3334-3336 DT denotes an
T1888 3337-3346 JJ denotes important
T1889 3347-3351 NN denotes role
T1890 3351-3352 -COMMA- denotes ,
T1891 3353-3356 CC denotes and
T1892 3357-3371 NN denotes administration
T1893 3372-3374 IN denotes of
T1894 3375-3378 NN denotes TNF
T1895 3379-3390 NN denotes antagonists
T1896 3391-3393 VB denotes is
T1897 3394-3396 DT denotes an
T1898 3397-3406 JJ denotes effective
T1899 3407-3416 NN denotes treatment
T1900 3417-3420 IN denotes for
T1901 3421-3427 JJ denotes severe
T1902 3428-3430 NN denotes RA
T1903 3431-3432 -LRB- denotes (
T1904 3432-3440 VB denotes reviewed
T1905 3441-3443 IN denotes in
T1906 3444-3445 -LRB- denotes [
T1907 3445-3446 CD denotes 9
T1908 3446-3447 -RRB- denotes ]
T1909 3447-3448 -RRB- denotes )
T1910 3450-3453 NN denotes TNF
T1911 3454-3457 CC denotes and
T1912 3458-3462 NN denotes IL-1
T1913 3463-3466 VB denotes are
T1914 3467-3471 DT denotes both
T1915 3472-3476 RB denotes very
T1916 3477-3483 JJ denotes potent
T1917 3484-3494 NN denotes activators
T1918 3495-3497 IN denotes of
T1919 3498-3503 NN denotes NF-κB
T1920 3504-3507 CC denotes and
T1921 3508-3510 PRP denotes it
T1922 3511-3514 MD denotes can
T1923 3515-3517 VB denotes be
T1924 3518-3526 VB denotes expected
T1925 3527-3531 IN denotes that
T1926 3532-3537 NN denotes NF-κB
T1927 3538-3548 NN denotes activation
T1928 3549-3551 IN denotes by
T1929 3552-3557 DT denotes these
T1930 3558-3567 NN denotes cytokines
T1931 3568-3576 VB denotes mediates
T1932 3577-3581 JJ denotes most
T1933 3582-3584 IN denotes of
T1934 3585-3590 PRP-DOLLAR- denotes their
T1935 3591-3607 JJ denotes pro-inflammatory
T1936 3608-3618 NN denotes activities
T1937 3619-3621 IN denotes in
T1938 3622-3624 NN denotes RA
T1939 3625-3626 -LRB- denotes (
T1940 3626-3634 VB denotes reviewed
T1941 3635-3637 IN denotes in
T1942 3638-3639 -LRB- denotes [
T1943 3639-3640 CD denotes 3
T1944 3640-3641 -RRB- denotes ]
T1945 3641-3642 -RRB- denotes )
T1946 3644-3649 NN denotes NF-κB
T1947 3650-3660 NN denotes activation
T1948 3661-3663 IN denotes by
T1949 3664-3672 NN denotes receptor
T1950 3673-3682 NN denotes activator
T1951 3683-3685 IN denotes of
T1952 3686-3691 NN denotes NF-κB
T1953 3692-3693 -LRB- denotes (
T1954 3693-3697 NN denotes RANK
T1955 3697-3698 -RRB- denotes )
T1956 3698-3699 -COMMA- denotes ,
T1957 3700-3701 DT denotes a
T1958 3702-3705 NN denotes TNF
T1959 3706-3714 NN denotes receptor
T1960 3715-3721 NN denotes family
T1961 3722-3728 NN denotes member
T1962 3728-3729 -COMMA- denotes ,
T1963 3730-3732 VB denotes is
T1964 3733-3742 JJ denotes important
T1965 3743-3746 IN denotes for
T1966 3747-3765 NN denotes osteoclastogenesis
T1967 3765-3766 -COMMA- denotes ,
T1968 3767-3770 CC denotes and
T1969 3771-3778 NN denotes defects
T1970 3779-3781 IN denotes in
T1971 3782-3788 JJ denotes proper
T1972 3789-3799 NN denotes RANK-NF-κB
T1973 3800-3810 NN denotes signalling
T1974 3811-3814 VB denotes are
T1975 3815-3821 JJ denotes likely
T1976 3822-3824 TO denotes to
T1977 3825-3827 VB denotes be
T1978 3828-3836 VB denotes involved
T1979 3837-3839 IN denotes in
T1980 3840-3842 NN denotes RA
T1981 3843-3852 NN denotes pathology
T1982 3853-3856 CC denotes and
T1983 3857-3862 JJ denotes other
T1984 3863-3871 NN denotes diseases
T1985 3872-3882 VB denotes associated
T1986 3883-3887 IN denotes with
T1987 3888-3892 NN denotes bone
T1988 3893-3897 NN denotes loss
T1989 3898-3899 -LRB- denotes [
T1990 3899-3900 CD denotes 7
T1991 3900-3901 -RRB- denotes ]
T1992 3903-3907 NN denotes CD40
T1993 3908-3910 VB denotes is
T1994 3911-3918 DT denotes another
T1995 3919-3922 NN denotes TNF
T1996 3923-3931 NN denotes receptor
T1997 3932-3938 NN denotes family
T1998 3939-3945 NN denotes member
T1999 3946-3950 WDT denotes that
T2000 3951-3953 VB denotes is
T2001 3954-3966 RB denotes functionally
T2002 3967-3976 VB denotes expressed
T2003 3977-3979 IN denotes on
T2004 3980-3981 DT denotes a
T2005 3982-3989 NN denotes variety
T2006 3990-3992 IN denotes of
T2007 3993-3997 NN denotes cell
T2008 3998-4003 NN denotes types
T2009 4003-4004 -COMMA- denotes ,
T2010 4005-4014 VB denotes including
T2011 4015-4021 JJ denotes smooth
T2012 4022-4028 NN denotes muscle
T2013 4029-4040 NN denotes fibroblasts
T2014 4041-4045 IN denotes from
T2015 4046-4052 JJ denotes normal
T2016 4053-4056 CC denotes and
T2017 4057-4059 NN denotes RA
T2018 4060-4068 NN denotes patients
T2019 4069-4072 CC denotes and
T2020 4073-4075 NN denotes RA
T2021 4076-4084 JJ denotes synovial
T2022 4085-4090 NN denotes cells
T2023 4090-4091 -COMMA- denotes ,
T2024 4092-4093 NN denotes B
T2025 4094-4099 NN denotes cells
T2026 4099-4100 -COMMA- denotes ,
T2027 4101-4112 NN denotes macrophages
T2028 4112-4113 -COMMA- denotes ,
T2029 4114-4117 CC denotes and
T2030 4118-4127 JJ denotes dendritic
T2031 4128-4133 NN denotes cells
T2032 4133-4134 -COMMA- denotes ,
T2033 4135-4138 CC denotes and
T2034 4139-4142 MD denotes can
T2035 4143-4145 VB denotes be
T2036 4146-4157 VB denotes upregulated
T2037 4158-4160 IN denotes by
T2038 4161-4176 JJ denotes proinflammatory
T2039 4177-4186 NN denotes cytokines
T2040 4187-4196 VB denotes including
T2041 4197-4200 NN denotes TNF
T2042 4201-4202 -LRB- denotes [
T2043 4202-4204 CD denotes 10
T2044 4204-4205 -RRB- denotes ]
T2045 4207-4214 NN denotes Binding
T2046 4215-4217 IN denotes of
T2047 4218-4221 DT denotes the
T2048 4222-4226 NN denotes CD40
T2049 4227-4233 NN denotes ligand
T2050 4234-4235 -LRB- denotes (
T2051 4235-4240 NN denotes CD154
T2052 4240-4241 -RRB- denotes )
T2053 4241-4242 -COMMA- denotes ,
T2054 4243-4248 WDT denotes which
T2055 4249-4251 VB denotes is
T2056 4252-4263 RB denotes transiently
T2057 4264-4273 VB denotes expressed
T2058 4274-4276 IN denotes on
T2059 4277-4280 DT denotes the
T2060 4281-4288 NN denotes surface
T2061 4289-4291 IN denotes of
T2062 4292-4301 VB denotes activated
T2063 4302-4306 JJ denotes CD4+
T2064 4307-4308 NN denotes T
T2065 4309-4314 NN denotes cells
T2066 4314-4315 -COMMA- denotes ,
T2067 4316-4324 VB denotes triggers
T2068 4325-4330 NN denotes NF-κB
T2069 4331-4341 NN denotes activation
T2070 4342-4351 VB denotes resulting
T2071 4352-4354 IN denotes in
T2072 4355-4365 NN denotes fibroblast
T2073 4366-4379 NN denotes proliferation
T2074 4380-4383 CC denotes and
T2075 4384-4393 NN denotes secretion
T2076 4394-4396 IN denotes of
T2077 4397-4412 JJ denotes proinflammatory
T2078 4413-4422 NN denotes cytokines
T2079 4423-4426 CC denotes and
T2080 4427-4437 NN denotes chemokines
T2081 4437-4438 -COMMA- denotes ,
T2082 4439-4444 WDT denotes which
T2083 4445-4456 VB denotes contributes
T2084 4457-4459 TO denotes to
T2085 4460-4465 JJ denotes joint
T2086 4466-4477 NN denotes destruction
T2087 4479-4486 RB denotes However
T2088 4486-4487 -COMMA- denotes ,
T2089 4488-4495 NN denotes studies
T2090 4496-4500 IN denotes with
T2091 4501-4513 JJ denotes antagonistic
T2092 4514-4523 NN denotes anti-CD40
T2093 4524-4526 CC denotes or
T2094 4527-4537 JJ denotes anti-CD154
T2095 4538-4548 NN denotes antibodies
T2096 4549-4552 VB denotes led
T2097 4553-4555 TO denotes to
T2098 4556-4559 DT denotes the
T2099 4560-4570 NN denotes conclusion
T2100 4571-4575 IN denotes that
T2101 4576-4580 NN denotes CD40
T2102 4581-4588 NN denotes signals
T2103 4589-4592 MD denotes may
T2104 4593-4595 VB denotes be
T2105 4596-4605 JJ denotes important
T2106 4606-4608 IN denotes at
T2107 4609-4612 DT denotes the
T2108 4613-4620 JJ denotes initial
T2109 4621-4627 NN denotes stages
T2110 4628-4630 IN denotes of
T2111 4631-4640 NN denotes arthritis
T2112 4641-4650 NN denotes induction
T2113 4650-4651 -COMMA- denotes ,
T2114 4652-4655 CC denotes but
T2115 4656-4659 VB denotes are
T2116 4660-4663 RB denotes not
T2117 4664-4672 VB denotes required
T2118 4673-4677 RB denotes once
T2119 4678-4685 NN denotes disease
T2120 4686-4688 VB denotes is
T2121 4689-4700 VB denotes established
T2122 4701-4704 CC denotes and
T2123 4705-4715 JJ denotes pathogenic
T2124 4716-4726 NN denotes antibodies
T2125 4727-4730 VB denotes are
T2126 4731-4738 RB denotes already
T2127 4739-4746 JJ denotes present
T2128 4747-4748 -LRB- denotes [
T2129 4748-4753 CD denotes 11,12
T2130 4753-4754 -RRB- denotes ]
T2131 4756-4764 VB denotes Enhanced
T2132 4765-4775 NN denotes expression
T2133 4776-4778 IN denotes of
T2134 4779-4782 DT denotes the
T2135 4783-4786 NN denotes TNF
T2136 4787-4795 NN denotes receptor
T2137 4796-4802 NN denotes family
T2138 4803-4809 NN denotes member
T2139 4810-4816 NN denotes B-cell
T2140 4817-4827 VB denotes activating
T2141 4828-4834 NN denotes factor
T2142 4835-4836 -LRB- denotes (
T2143 4836-4840 NN denotes BAFF
T2144 4840-4841 -RRB- denotes )
T2145 4841-4842 -COMMA- denotes ,
T2146 4843-4851 VB denotes allowing
T2147 4852-4855 DT denotes the
T2148 4856-4864 NN denotes survival
T2149 4865-4867 IN denotes of
T2150 4868-4881 NN denotes autoantibody-
T2151 4882-4891 VB denotes producing
T2152 4892-4893 NN denotes B
T2153 4894-4905 NN denotes lymphocytes
T2154 4905-4906 -COMMA- denotes ,
T2155 4907-4909 VB denotes is
T2156 4910-4914 RB denotes also
T2157 4915-4929 JJ denotes characteristic
T2158 4930-4933 IN denotes for
T2159 4934-4936 NN denotes RA
T2160 4936-4937 -COMMA- denotes ,
T2161 4938-4941 CC denotes and
T2162 4942-4953 NN denotes antagonists
T2163 4954-4956 IN denotes of
T2164 4957-4961 NN denotes BAFF
T2165 4962-4966 VB denotes have
T2166 4967-4971 VB denotes been
T2167 4972-4981 VB denotes developed
T2168 4982-4984 TO denotes to
T2169 4985-4992 VB denotes counter
T2170 4993-4995 NN denotes RA
T2171 4996-4997 -LRB- denotes [
T2172 4997-4999 CD denotes 13
T2173 4999-5000 -RRB- denotes ]
T2174 5002-5009 RB denotes Finally
T2175 5009-5010 -COMMA- denotes ,
T2176 5011-5022 NN denotes lymphotoxin
T2177 5023-5024 NN denotes β
T2178 5025-5033 NN denotes receptor
T2179 5034-5044 NN denotes signalling
T2180 5045-5048 VB denotes has
T2181 5049-5053 VB denotes been
T2182 5054-5064 VB denotes implicated
T2183 5065-5067 IN denotes in
T2184 5068-5076 JJ denotes tertiary
T2185 5077-5085 JJ denotes lymphoid
T2186 5086-5091 NN denotes organ
T2187 5092-5101 NN denotes formation
T2188 5102-5104 IN denotes at
T2189 5105-5110 NN denotes sites
T2190 5111-5113 IN denotes of
T2191 5114-5121 JJ denotes chronic
T2192 5122-5134 NN denotes inflammation
T2193 5135-5144 VB denotes including
T2194 5145-5147 NN denotes RA
T2195 5148-5149 -LRB- denotes [
T2196 5149-5151 CD denotes 13
T2197 5151-5152 -RRB- denotes ]
T2198 5154-5163 JJ denotes Toll-like
T2199 5164-5173 NN denotes receptors
T2200 5174-5175 -LRB- denotes (
T2201 5175-5179 NN denotes TLRs
T2202 5179-5180 -RRB- denotes )
T2203 5181-5185 VB denotes have
T2204 5186-5190 VB denotes been
T2205 5191-5201 VB denotes implicated
T2206 5202-5204 IN denotes in
T2207 5205-5206 DT denotes a
T2208 5207-5214 NN denotes variety
T2209 5215-5217 IN denotes of
T2210 5218-5228 JJ denotes autoimmune
T2211 5229-5237 NN denotes diseases
T2212 5238-5241 CC denotes and
T2213 5242-5245 VB denotes are
T2214 5246-5255 JJ denotes potential
T2215 5256-5266 NN denotes candidates
T2216 5267-5270 IN denotes for
T2217 5271-5279 VB denotes inducing
T2218 5280-5295 JJ denotes NF-κB-dependent
T2219 5296-5308 NN denotes inflammation
T2220 5309-5311 IN denotes in
T2221 5312-5314 NN denotes RA
T2222 5316-5318 IN denotes In
T2223 5319-5327 NN denotes addition
T2224 5328-5330 TO denotes to
T2225 5331-5340 JJ denotes microbial
T2226 5341-5348 NN denotes ligands
T2227 5348-5349 -COMMA- denotes ,
T2228 5350-5352 DT denotes an
T2229 5353-5363 VB denotes increasing
T2230 5364-5370 NN denotes number
T2231 5371-5373 IN denotes of
T2232 5374-5384 JJ denotes endogenous
T2233 5385-5392 NN denotes ligands
T2234 5393-5394 -COLON- denotes -
T2235 5395-5396 DT denotes a
T2236 5397-5402 NN denotes group
T2237 5403-5405 IN denotes of
T2238 5406-5414 NN denotes proteins
T2239 5415-5422 VB denotes derived
T2240 5423-5427 IN denotes from
T2241 5428-5432 NN denotes host
T2242 5433-5440 NN denotes tissues
T2243 5441-5444 CC denotes and
T2244 5445-5450 NN denotes cells
T2245 5451-5452 -COLON- denotes -
T2246 5453-5457 VB denotes have
T2247 5458-5462 VB denotes been
T2248 5463-5471 VB denotes reported
T2249 5472-5474 IN denotes as
T2250 5475-5484 NN denotes candidate
T2251 5485-5495 NN denotes activators
T2252 5496-5498 IN denotes of
T2253 5499-5503 NN denotes TLRs
T2254 5504-5512 VB denotes inducing
T2255 5513-5522 JJ denotes so-called
T2256 5523-5530 JJ denotes sterile
T2257 5531-5543 NN denotes inflammation
T2258 5544-5545 -LRB- denotes (
T2259 5545-5553 VB denotes reviewed
T2260 5554-5556 IN denotes in
T2261 5557-5558 -LRB- denotes [
T2262 5558-5563 CD denotes 14,15
T2263 5563-5564 -RRB- denotes ]
T2264 5564-5565 -RRB- denotes )
T2265 5567-5571 NN denotes TLRs
T2266 5572-5575 VB denotes are
T2267 5576-5585 VB denotes expressed
T2268 5586-5588 IN denotes in
T2269 5589-5591 NN denotes RA
T2270 5592-5600 JJ denotes synovial
T2271 5601-5608 NN denotes tissues
T2272 5609-5612 CC denotes and
T2273 5613-5620 JJ denotes various
T2274 5621-5631 JJ denotes endogenous
T2275 5632-5639 NN denotes ligands
T2276 5640-5643 VB denotes are
T2277 5644-5651 JJ denotes present
T2278 5652-5658 IN denotes within
T2279 5659-5662 DT denotes the
T2280 5663-5671 JJ denotes inflamed
T2281 5672-5678 NN denotes joints
T2282 5679-5681 IN denotes of
T2283 5682-5684 NN denotes RA
T2284 5685-5693 NN denotes patients
T2285 5695-5703 RB denotes Moreover
T2286 5703-5704 -COMMA- denotes ,
T2287 5705-5711 NN denotes animal
T2288 5712-5718 NN denotes models
T2289 5719-5724 VB denotes using
T2290 5725-5728 NN denotes TLR
T2291 5729-5737 NN denotes knockout
T2292 5738-5742 NN denotes mice
T2293 5743-5745 CC denotes or
T2294 5746-5756 NN denotes strategies
T2295 5757-5759 TO denotes to
T2296 5760-5765 VB denotes block
T2297 5766-5769 NN denotes TLR
T2298 5770-5780 NN denotes signalling
T2299 5781-5788 RB denotes clearly
T2300 5789-5797 VB denotes identify
T2301 5798-5811 JJ denotes TLR-dependent
T2302 5812-5824 NN denotes inflammation
T2303 5825-5827 IN denotes as
T2304 5828-5833 VB denotes being
T2305 5834-5843 JJ denotes important
T2306 5844-5846 IN denotes in
T2307 5847-5850 DT denotes the
T2308 5851-5863 NN denotes pathogenesis
T2309 5864-5866 IN denotes of
T2310 5867-5870 DT denotes the
T2311 5871-5878 NN denotes disease
T2312 5880-5884 JJ denotes High
T2313 5885-5893 NN denotes mobility
T2314 5894-5899 NN denotes group
T2315 5900-5903 NN denotes box
T2316 5904-5915 JJ denotes chromosomal
T2317 5916-5923 NN denotes protein
T2318 5924-5925 CD denotes 1
T2319 5926-5927 -LRB- denotes (
T2320 5927-5932 NN denotes HMGB1
T2321 5932-5933 -RRB- denotes )
T2322 5933-5934 -COMMA- denotes ,
T2323 5935-5936 DT denotes a
T2324 5937-5943 RB denotes highly
T2325 5944-5953 VB denotes conserved
T2326 5954-5963 NN denotes chromatin
T2327 5964-5973 NN denotes component
T2328 5974-5978 WDT denotes that
T2329 5979-5982 MD denotes can
T2330 5983-5985 VB denotes be
T2331 5986-5994 RB denotes actively
T2332 5995-6003 VB denotes secreted
T2333 6004-6006 IN denotes by
T2334 6007-6018 NN denotes macrophages
T2335 6019-6021 CC denotes or
T2336 6022-6031 RB denotes passively
T2337 6032-6040 VB denotes released
T2338 6041-6043 IN denotes by
T2339 6044-6052 JJ denotes necrotic
T2340 6053-6058 NN denotes cells
T2341 6058-6059 -COMMA- denotes ,
T2342 6060-6062 VB denotes is
T2343 6063-6066 CD denotes one
T2344 6067-6069 IN denotes of
T2345 6070-6073 DT denotes the
T2346 6074-6078 RB denotes most
T2347 6079-6087 JJ denotes putative
T2348 6088-6098 JJ denotes endogenous
T2349 6099-6103 NN denotes TLR4
T2350 6104-6111 NN denotes ligands
T2351 6112-6120 VB denotes involved
T2352 6121-6123 IN denotes in
T2353 6124-6126 NN denotes RA
T2354 6127-6136 NN denotes pathology
T2355 6138-6143 NN denotes HMGB1
T2356 6144-6146 VB denotes is
T2357 6147-6156 VB denotes increased
T2358 6157-6159 IN denotes in
T2359 6160-6162 NN denotes RA
T2360 6163-6171 JJ denotes synovial
T2361 6172-6178 NN denotes tissue
T2362 6179-6182 CC denotes and
T2363 6183-6188 NN denotes HMGB1
T2364 6189-6201 VB denotes neutralising
T2365 6202-6212 NN denotes antibodies
T2366 6213-6215 CC denotes or
T2367 6216-6219 DT denotes the
T2368 6220-6232 JJ denotes antagonistic
T2369 6233-6237 NN denotes BoxA
T2370 6238-6244 NN denotes domain
T2371 6245-6247 IN denotes of
T2372 6248-6253 NN denotes HMGB1
T2373 6254-6261 NN denotes protect
T2374 6262-6269 IN denotes against
T2375 6270-6286 JJ denotes collagen-induced
T2376 6287-6296 NN denotes arthritis
T2377 6297-6299 IN denotes in
T2378 6300-6304 NN denotes mice
T2379 6305-6306 -LRB- denotes [
T2380 6306-6308 CD denotes 16
T2381 6308-6309 -RRB- denotes ]
T2382 6311-6326 JJ denotes Myeloid-related
T2383 6327-6334 NN denotes protein
T2384 6335-6336 CD denotes 8
T2385 6337-6340 CC denotes and
T2386 6341-6356 JJ denotes myeloid-related
T2387 6357-6364 NN denotes protein
T2388 6365-6367 CD denotes 14
T2389 6367-6368 -COMMA- denotes ,
T2390 6369-6386 JJ denotes damage-associated
T2391 6387-6396 JJ denotes molecular
T2392 6397-6404 NN denotes pattern
T2393 6405-6414 NN denotes molecules
T2394 6415-6424 VB denotes belonging
T2395 6425-6427 TO denotes to
T2396 6428-6431 DT denotes the
T2397 6432-6436 NN denotes S100
T2398 6437-6443 NN denotes family
T2399 6444-6446 IN denotes of
T2400 6447-6462 JJ denotes calcium-binding
T2401 6463-6471 NN denotes proteins
T2402 6471-6472 -COMMA- denotes ,
T2403 6473-6476 VB denotes are
T2404 6477-6481 RB denotes also
T2405 6482-6492 RB denotes abundantly
T2406 6493-6500 JJ denotes present
T2407 6501-6503 IN denotes in
T2408 6504-6506 NN denotes RA
T2409 6507-6515 JJ denotes synovial
T2410 6516-6521 NN denotes fluid
T2411 6521-6522 -COMMA- denotes ,
T2412 6523-6526 CC denotes and
T2413 6527-6531 VB denotes have
T2414 6532-6536 VB denotes been
T2415 6537-6546 VB denotes suggested
T2416 6547-6549 TO denotes to
T2417 6550-6552 VB denotes be
T2418 6553-6561 VB denotes involved
T2419 6562-6564 IN denotes in
T2420 6565-6577 JJ denotes TLR4-induced
T2421 6578-6585 JJ denotes chronic
T2422 6586-6598 NN denotes inflammation
T2423 6599-6601 IN denotes in
T2424 6602-6604 NN denotes RA
T2425 6605-6606 -LRB- denotes [
T2426 6606-6611 CD denotes 17,18
T2427 6611-6612 -RRB- denotes ]
T2428 6614-6619 JJ denotes Other
T2429 6620-6630 JJ denotes endogenous
T2430 6631-6634 NN denotes TLR
T2431 6635-6642 NN denotes ligands
T2432 6643-6647 WDT denotes that
T2433 6648-6651 MD denotes may
T2434 6652-6654 VB denotes be
T2435 6655-6663 VB denotes involved
T2436 6664-6666 IN denotes in
T2437 6667-6669 NN denotes RA
T2438 6670-6679 NN denotes pathology
T2439 6680-6683 VB denotes are
T2440 6684-6697 JJ denotes extracellular
T2441 6698-6704 NN denotes matrix
T2442 6705-6715 NN denotes components
T2443 6716-6720 JJ denotes such
T2444 6721-6723 IN denotes as
T2445 6724-6734 NN denotes fibrinogen
T2446 6734-6735 -COMMA- denotes ,
T2447 6736-6747 NN denotes fibronectin
T2448 6747-6748 -COMMA- denotes ,
T2449 6749-6757 NN denotes biglycan
T2450 6757-6758 -COMMA- denotes ,
T2451 6759-6767 NN denotes tenascin
T2452 6768-6769 NN denotes C
T2453 6769-6770 -COMMA- denotes ,
T2454 6771-6774 CC denotes and
T2455 6775-6786 JJ denotes hyal-uronic
T2456 6787-6791 NN denotes acid
T2457 6792-6801 NN denotes fragments
T2458 6802-6803 -LRB- denotes (
T2459 6803-6811 VB denotes reviewed
T2460 6812-6814 IN denotes in
T2461 6815-6816 -LRB- denotes [
T2462 6816-6821 CD denotes 14,15
T2463 6821-6822 -RRB- denotes ]
T2464 6822-6823 -RRB- denotes )
T2465 6825-6833 RB denotes Together
T2466 6833-6834 -COMMA- denotes ,
T2467 6835-6840 DT denotes these
T2468 6841-6848 NN denotes studies
T2469 6849-6856 VB denotes suggest
T2470 6857-6861 IN denotes that
T2471 6862-6869 JJ denotes several
T2472 6870-6873 NN denotes TLR
T2473 6874-6881 NN denotes ligands
T2474 6882-6884 IN denotes in
T2475 6885-6888 DT denotes the
T2476 6889-6897 JJ denotes inflamed
T2477 6898-6903 JJ denotes joint
T2478 6904-6910 NN denotes tissue
T2479 6911-6914 MD denotes may
T2480 6915-6925 VB denotes contribute
T2481 6926-6928 TO denotes to
T2482 6929-6934 NN denotes NF-κB
T2483 6935-6945 NN denotes activation
T2484 6946-6949 CC denotes and
T2485 6950-6962 JJ denotes inflammatory
T2486 6963-6967 NN denotes gene
T2487 6968-6978 NN denotes expression
T2488 6979-6981 IN denotes in
T2489 6982-6984 NN denotes RA
T4572 7024-7029 NN denotes NF-κB
T4573 7030-7038 NN denotes proteins
T4574 7039-7042 VB denotes are
T4575 7043-7054 VB denotes sequestered
T4576 7055-7057 IN denotes in
T4577 7058-7061 DT denotes the
T4578 7062-7071 NN denotes cytoplasm
T4579 7072-7074 IN denotes as
T4580 7075-7081 JJ denotes latent
T4581 7082-7091 NN denotes complexes
T4582 7092-7094 IN denotes by
T4583 7095-7105 JJ denotes inhibitory
T4584 7106-7114 NN denotes proteins
T4585 7115-7123 VB denotes referred
T4586 7124-7126 TO denotes to
T4587 7127-7129 IN denotes as
T4588 7130-7139 NN denotes inhibitor
T4589 7140-7142 IN denotes of
T4590 7143-7148 NN denotes NF-κB
T4591 7149-7150 -LRB- denotes (
T4592 7150-7153 NN denotes IκB
T4593 7153-7154 -RRB- denotes )
T4594 7155-7163 NN denotes proteins
T4595 7163-7164 -COMMA- denotes ,
T4596 7165-7170 WDT denotes which
T4597 7171-7178 VB denotes prevent
T4598 7179-7184 NN denotes NF-κB
T4599 7185-7192 JJ denotes nuclear
T4600 7193-7206 NN denotes translocation
T4601 7207-7210 CC denotes and
T4602 7211-7214 NN denotes DNA
T4603 7215-7222 NN denotes binding
T4604 7223-7224 -LRB- denotes [
T4605 7224-7226 CD denotes 19
T4606 7226-7227 -RRB- denotes ]
T4607 7229-7236 IN denotes Whereas
T4608 7237-7240 DT denotes the
T4609 7241-7249 NN denotes majority
T4610 7250-7252 IN denotes of
T4611 7253-7257 NN denotes IκBs
T4612 7258-7259 -LRB- denotes (
T4613 7259-7263 NN denotes IκBα
T4614 7263-7264 -COMMA- denotes ,
T4615 7265-7269 NN denotes IκBβ
T4616 7269-7270 -COMMA- denotes ,
T4617 7271-7275 NN denotes IκBε
T4618 7275-7276 -COMMA- denotes ,
T4619 7277-7281 NN denotes p105
T4620 7282-7283 -LRB- denotes (
T4621 7283-7287 RB denotes also
T4622 7288-7293 VB denotes known
T4623 7294-7296 IN denotes as
T4624 7297-7303 NN denotes NF-κB1
T4625 7303-7304 -RRB- denotes )
T4626 7304-7305 -COMMA- denotes ,
T4627 7306-7310 NN denotes p100
T4628 7311-7312 -LRB- denotes (
T4629 7312-7316 RB denotes also
T4630 7317-7322 VB denotes known
T4631 7323-7325 IN denotes as
T4632 7326-7332 NN denotes NF-κB2
T4633 7332-7333 -RRB- denotes )
T4634 7333-7334 -RRB- denotes )
T4635 7335-7340 VB denotes serve
T4636 7341-7343 IN denotes as
T4637 7344-7354 NN denotes inhibitors
T4638 7355-7357 IN denotes of
T4639 7358-7363 NN denotes NF-κB
T4640 7363-7364 -COMMA- denotes ,
T4641 7365-7369 NN denotes IκBξ
T4642 7370-7373 CC denotes and
T4643 7374-7379 NN denotes Bcl-3
T4644 7380-7387 RB denotes instead
T4645 7388-7398 VB denotes potentiate
T4646 7399-7404 NN denotes NF-κB
T4647 7405-7420 NN denotes transactivation
T4648 7421-7423 IN denotes in
T4649 7424-7427 DT denotes the
T4650 7428-7436 NN denotes nucleus.
T4651 7437-7441 NN denotes p100
T4652 7442-7445 CC denotes and
T4653 7446-7450 NN denotes p105
T4654 7451-7454 VB denotes are
T4655 7455-7465 NN denotes precursors
T4656 7466-7468 IN denotes of
T4657 7469-7472 DT denotes the
T4658 7473-7476 NN denotes p52
T4659 7477-7480 CC denotes and
T4660 7481-7484 NN denotes p50
T4661 7485-7490 NN denotes NF-κB
T4662 7491-7499 NN denotes subunits
T4663 7499-7500 -COMMA- denotes ,
T4664 7501-7513 RB denotes respectively
T4665 7515-7520 EX denotes There
T4666 7521-7524 VB denotes are
T4667 7525-7528 CD denotes two
T4668 7529-7535 JJ denotes unique
T4669 7536-7541 NN denotes NF-κB
T4670 7542-7552 NN denotes signalling
T4671 7553-7561 NN denotes pathways
T4672 7561-7562 -COMMA- denotes ,
T4673 7563-7569 VB denotes termed
T4674 7570-7579 JJ denotes canonical
T4675 7580-7581 -LRB- denotes (
T4676 7581-7583 CC denotes or
T4677 7584-7593 JJ denotes classical
T4678 7593-7594 -RRB- denotes )
T4679 7595-7598 CC denotes and
T4680 7599-7611 JJ denotes noncanonical
T4681 7612-7613 -LRB- denotes (
T4682 7613-7615 CC denotes or
T4683 7616-7627 JJ denotes alternative
T4684 7627-7628 -RRB- denotes )
T4685 7629-7634 NN denotes NF-κB
T4686 7635-7643 NN denotes pathways
T4687 7645-7648 DT denotes The
T4688 7649-7658 JJ denotes canonical
T4689 7659-7664 NN denotes NF-κB
T4690 7665-7672 NN denotes pathway
T4691 7673-7678 VB denotes plays
T4692 7679-7680 DT denotes a
T4693 7681-7686 JJ denotes major
T4694 7687-7691 NN denotes role
T4695 7692-7694 IN denotes in
T4696 7695-7701 JJ denotes innate
T4697 7702-7705 CC denotes and
T4698 7706-7714 JJ denotes adaptive
T4699 7715-7723 NN denotes immunity
T4700 7723-7724 -COMMA- denotes ,
T4701 7725-7728 CC denotes and
T4702 7729-7731 VB denotes is
T4703 7732-7741 VB denotes triggered
T4704 7742-7744 IN denotes by
T4705 7745-7749 JJ denotes many
T4706 7750-7757 NN denotes stimuli
T4707 7758-7767 VB denotes including
T4708 7768-7783 JJ denotes proinflammatory
T4709 7784-7793 NN denotes cytokines
T4710 7794-7795 -LRB- denotes (
T4711 7795-7798 IN denotes for
T4712 7799-7806 NN denotes example
T4713 7806-7807 -COMMA- denotes ,
T4714 7808-7811 NN denotes TNF
T4715 7811-7812 -COMMA- denotes ,
T4716 7813-7817 NN denotes IL-1
T4717 7817-7818 -RRB- denotes )
T4718 7818-7819 -COMMA- denotes ,
T4719 7820-7828 NN denotes antigens
T4720 7828-7829 -COMMA- denotes ,
T4721 7830-7835 NN denotes RANKL
T4722 7835-7836 -COMMA- denotes ,
T4723 7837-7840 CC denotes and
T4724 7841-7844 NN denotes TLR
T4725 7845-7852 NN denotes ligands
T4726 7854-7859 NN denotes NF-κB
T4727 7860-7870 NN denotes signalling
T4728 7871-7880 VB denotes initiated
T4729 7881-7883 IN denotes by
T4730 7884-7893 JJ denotes different
T4731 7894-7903 NN denotes receptors
T4732 7904-7912 VB denotes requires
T4733 7913-7916 DT denotes the
T4734 7917-7926 NN denotes formation
T4735 7927-7929 IN denotes of
T4736 7930-7938 JJ denotes proximal
T4737 7939-7954 JJ denotes protein-protein
T4738 7955-7967 NN denotes interactions
T4739 7968-7972 WDT denotes that
T4740 7973-7976 VB denotes are
T4741 7977-7982 RB denotes often
T4742 7983-7991 NN denotes receptor
T4743 7992-8000 JJ denotes specific
T4744 8000-8001 -COMMA- denotes ,
T4745 8002-8005 CC denotes but
T4746 8006-8016 RB denotes ultimately
T4747 8017-8025 VB denotes converge
T4748 8026-8028 IN denotes in
T4749 8029-8032 DT denotes the
T4750 8033-8043 NN denotes activation
T4751 8044-8046 IN denotes of
T4752 8047-8050 DT denotes the
T4753 8051-8054 NN denotes IκB
T4754 8055-8061 NN denotes kinase
T4755 8062-8063 -LRB- denotes (
T4756 8063-8066 NN denotes IKK
T4757 8066-8067 -RRB- denotes )
T4758 8068-8075 NN denotes complex
T4759 8075-8076 -COMMA- denotes ,
T4760 8077-8082 WDT denotes which
T4761 8083-8091 VB denotes mediates
T4762 8092-8107 NN denotes phosphorylation
T4763 8108-8110 IN denotes of
T4764 8111-8114 DT denotes the
T4765 8115-8125 JJ denotes inhibitory
T4766 8126-8129 NN denotes IκB
T4767 8130-8137 NN denotes protein
T4768 8138-8145 VB denotes leading
T4769 8146-8148 TO denotes to
T4770 8149-8152 PRP-DOLLAR- denotes its
T4771 8153-8175 NN denotes K48-polyubiquitination
T4772 8176-8179 CC denotes and
T4773 8180-8191 NN denotes degradation
T4774 8192-8194 IN denotes by
T4775 8195-8198 DT denotes the
T4776 8199-8209 NN denotes proteasome
T4777 8210-8211 -LRB- denotes [
T4778 8211-8213 CD denotes 20
T4779 8213-8214 -RRB- denotes ]
T4780 8216-8219 DT denotes The
T4781 8220-8223 NN denotes IKK
T4782 8224-8231 NN denotes complex
T4783 8232-8234 VB denotes is
T4784 8235-8244 VB denotes comprised
T4785 8245-8247 IN denotes of
T4786 8248-8251 DT denotes the
T4787 8252-8255 CD denotes two
T4788 8256-8265 JJ denotes catalytic
T4789 8266-8274 NN denotes subunits
T4790 8275-8279 NN denotes IKK1
T4791 8280-8283 CC denotes and
T4792 8284-8288 NN denotes IKK2
T4793 8289-8290 -LRB- denotes (
T4794 8290-8294 RB denotes also
T4795 8295-8300 VB denotes known
T4796 8301-8303 IN denotes as
T4797 8304-8308 NN denotes IKKα
T4798 8309-8312 CC denotes and
T4799 8313-8317 NN denotes IKKβ
T4800 8317-8318 -RRB- denotes )
T4801 8319-8322 CC denotes and
T4802 8323-8326 DT denotes the
T4803 8327-8337 JJ denotes regulatory
T4804 8338-8345 NN denotes subunit
T4805 8346-8351 NN denotes NF-κB
T4806 8352-8361 JJ denotes essential
T4807 8362-8371 NN denotes modulator
T4808 8372-8373 -LRB- denotes (
T4809 8373-8377 NN denotes NEMO
T4810 8378-8379 -COLON- denotes -
T4811 8380-8384 RB denotes also
T4812 8385-8390 VB denotes known
T4813 8391-8393 IN denotes as
T4814 8394-8398 NN denotes IKKγ
T4815 8398-8399 -RRB- denotes )
T4816 8400-8401 -LRB- denotes (
T4817 8401-8407 NN denotes Figure
T4818 8408-8409 CD denotes 1
T4819 8409-8410 -RRB- denotes )
T4820 8412-8416 NN denotes Gene
T4821 8417-8426 VB denotes targeting
T4822 8427-8438 NN denotes experiments
T4823 8439-8445 VB denotes showed
T4824 8446-8450 IN denotes that
T4825 8451-8455 NN denotes IKK2
T4826 8456-8459 CC denotes and
T4827 8460-8464 NN denotes NEMO
T4828 8464-8465 -COMMA- denotes ,
T4829 8466-8469 CC denotes but
T4830 8470-8473 RB denotes not
T4831 8474-8478 NN denotes IKK1
T4832 8478-8479 -COMMA- denotes ,
T4833 8480-8483 VB denotes are
T4834 8484-8492 VB denotes required
T4835 8493-8496 IN denotes for
T4836 8497-8506 JJ denotes canonical
T4837 8507-8512 NN denotes NF-κB
T4838 8513-8523 NN denotes activation
T4839 8524-8525 -LRB- denotes [
T4840 8525-8527 CD denotes 21
T4841 8527-8528 -RRB- denotes ]
T19640 8540-8549 JJ denotes Canonical
T19641 8550-8555 NN denotes NF-κB
T19642 8556-8566 NN denotes signalling
T19643 8567-8570 CC denotes and
T19644 8571-8579 JJ denotes negative
T19645 8580-8590 NN denotes regulators
T19646 8592-8598 NN denotes Ligand
T19647 8599-8609 NN denotes engagement
T19648 8610-8612 IN denotes of
T19649 8613-8621 JJ denotes specific
T19650 8622-8630 NN denotes membrane
T19651 8631-8640 NN denotes receptors
T19652 8641-8645 JJ denotes such
T19653 8646-8648 IN denotes as
T19654 8649-8654 NN denotes TNFR1
T19655 8654-8655 -COMMA- denotes ,
T19656 8656-8660 NN denotes CD40
T19657 8660-8661 -COMMA- denotes ,
T19658 8662-8666 NN denotes RANK
T19659 8666-8667 -COMMA- denotes ,
T19660 8668-8671 CC denotes and
T19661 8672-8676 NN denotes TLR4
T19662 8677-8684 VB denotes trigger
T19663 8685-8688 DT denotes the
T19664 8689-8700 NN denotes recruitment
T19665 8701-8703 IN denotes of
T19666 8704-8712 JJ denotes specific
T19667 8713-8720 NN denotes adaptor
T19668 8721-8729 NN denotes proteins
T19669 8730-8731 -LRB- denotes (
T19670 8731-8734 NN denotes TNF
T19671 8735-8743 NN denotes receptor
T19672 8744-8756 JJ denotes 1-associated
T19673 8757-8762 NN denotes death
T19674 8763-8769 NN denotes domain
T19675 8770-8777 NN denotes protein
T19676 8778-8779 -LRB- denotes (
T19677 8779-8784 NN denotes TRADD
T19678 8784-8785 -RRB- denotes )
T19679 8785-8786 -COMMA- denotes ,
T19680 8787-8792 NN denotes MyD88
T19681 8792-8793 -COMMA- denotes ,
T19682 8794-8797 NNP denotes MAL
T19683 8797-8798 -COMMA- denotes ,
T19684 8799-8802 NN denotes TIR
T19685 8803-8820 JJ denotes domain-containing
T19686 8821-8837 JJ denotes adaptor-inducing
T19687 8838-8842 NN denotes IFNβ
T19688 8843-8844 -LRB- denotes (
T19689 8844-8848 NN denotes TRIF
T19690 8848-8849 -RRB- denotes )
T19691 8849-8850 -RRB- denotes )
T19692 8850-8851 -COMMA- denotes ,
T19693 8852-8859 NN denotes kinases
T19694 8860-8861 -LRB- denotes (
T19695 8861-8865 NN denotes RIP1
T19696 8865-8866 -COMMA- denotes ,
T19697 8867-8872 NN denotes IRAK1
T19698 8872-8873 -COMMA- denotes ,
T19699 8874-8879 NN denotes IRAK4
T19700 8879-8880 -RRB- denotes )
T19701 8880-8881 -COMMA- denotes ,
T19702 8882-8885 CC denotes and
T19703 8886-8895 NN denotes ubiquitin
T19704 8896-8903 NN denotes ligases
T19705 8904-8905 -LRB- denotes (
T19706 8905-8910 NN denotes TRAF2
T19707 8910-8911 -COMMA- denotes ,
T19708 8912-8917 NN denotes TRAF6
T19709 8917-8918 -COMMA- denotes ,
T19710 8919-8924 NN denotes cIAP1
T19711 8924-8925 -COMMA- denotes ,
T19712 8926-8931 NN denotes cIAP2
T19713 8931-8932 -RRB- denotes )
T19714 8933-8935 TO denotes to
T19715 8936-8939 DT denotes the
T19716 8940-8948 NN denotes receptor
T19717 8950-8960 JJ denotes K63-linked
T19718 8961-8979 NN denotes polyubiquitination
T19719 8980-8982 IN denotes of
T19720 8983-8988 NN denotes TRAFs
T19721 8988-8989 -COMMA- denotes ,
T19722 8990-8994 NN denotes RIP1
T19723 8995-8998 CC denotes and
T19724 8999-9004 NN denotes IRAK1
T19725 9004-9005 -COMMA- denotes ,
T19726 9006-9008 VB denotes is
T19727 9009-9019 VB denotes recognised
T19728 9020-9022 IN denotes by
T19729 9023-9027 NN denotes NEMO
T19730 9028-9031 CC denotes and
T19731 9032-9035 NN denotes TAB
T19732 9036-9044 NN denotes proteins
T19733 9044-9045 -COMMA- denotes ,
T19734 9046-9055 VB denotes resulting
T19735 9056-9058 IN denotes in
T19736 9059-9062 DT denotes the
T19737 9063-9074 NN denotes recruitment
T19738 9075-9078 CC denotes and
T19739 9079-9089 NN denotes activation
T19740 9090-9092 IN denotes of
T19741 9093-9105 RB denotes respectively
T19742 9106-9110 NN denotes IKK2
T19743 9111-9114 CC denotes and
T19744 9115-9119 NN denotes TAK1
T19745 9121-9125 NN denotes TAK1
T19746 9126-9130 RB denotes then
T19747 9131-9145 VB denotes phosphorylates
T19748 9146-9149 CC denotes and
T19749 9150-9159 VB denotes activates
T19750 9160-9164 NN denotes IKK2
T19751 9164-9165 -COMMA- denotes ,
T19752 9166-9171 WDT denotes which
T19753 9172-9174 IN denotes in
T19754 9175-9179 NN denotes turn
T19755 9180-9194 VB denotes phosphorylates
T19756 9195-9199 NN denotes IκBα
T19757 9199-9200 -COMMA- denotes ,
T19758 9201-9211 VB denotes triggering
T19759 9212-9215 PRP-DOLLAR- denotes its
T19760 9216-9226 JJ denotes K48-linked
T19761 9227-9241 NN denotes ubiquitination
T19762 9242-9245 CC denotes and
T19763 9246-9257 JJ denotes proteasomal
T19764 9258-9269 NN denotes degradation
T19765 9271-9275 DT denotes This
T19766 9276-9282 VB denotes allows
T19767 9283-9288 NN denotes NF-κB
T19768 9289-9290 -LRB- denotes (
T19769 9290-9294 RB denotes here
T19770 9295-9300 VB denotes shown
T19771 9301-9303 IN denotes as
T19772 9304-9305 DT denotes a
T19773 9306-9317 NN denotes heterodimer
T19774 9318-9320 IN denotes of
T19775 9321-9324 NN denotes p65
T19776 9325-9328 CC denotes and
T19777 9329-9332 NN denotes p50
T19778 9332-9333 -RRB- denotes )
T19779 9334-9336 TO denotes to
T19780 9337-9348 VB denotes translocate
T19781 9349-9351 TO denotes to
T19782 9352-9355 DT denotes the
T19783 9356-9363 NN denotes nucleus
T19784 9364-9367 CC denotes and
T19785 9368-9375 VB denotes promote
T19786 9376-9382 NN denotes target
T19787 9383-9387 NN denotes gene
T19788 9388-9398 NN denotes expression
T19789 9400-9405 NN denotes TRAF1
T19790 9405-9406 -COMMA- denotes ,
T19791 9407-9412 WDT denotes which
T19792 9413-9416 VB denotes has
T19793 9417-9419 DT denotes no
T19794 9420-9429 NN denotes ubiquitin
T19795 9430-9436 NN denotes ligase
T19796 9437-9445 NN denotes activity
T19797 9445-9446 -COMMA- denotes ,
T19798 9447-9450 MD denotes can
T19799 9451-9461 RB denotes negatively
T19800 9462-9470 VB denotes regulate
T19801 9471-9476 NN denotes NF-κB
T19802 9477-9487 NN denotes activation
T19803 9487-9488 -COMMA- denotes ,
T19804 9489-9493 RB denotes most
T19805 9494-9502 RB denotes probably
T19806 9503-9505 IN denotes by
T19807 9506-9515 VB denotes competing
T19808 9516-9520 IN denotes with
T19809 9521-9526 JJ denotes other
T19810 9527-9532 NN denotes TRAFs
T19811 9534-9537 NN denotes A20
T19812 9538-9541 CC denotes and
T19813 9542-9546 NN denotes CYLD
T19814 9547-9550 VB denotes are
T19815 9551-9567 VB denotes deubiquitinating
T19816 9568-9575 NN denotes enzymes
T19817 9576-9580 WDT denotes that
T19818 9581-9588 VB denotes control
T19819 9589-9594 NN denotes NF-κB
T19820 9595-9605 NN denotes activation
T19821 9606-9608 IN denotes by
T19822 9609-9618 VB denotes targeting
T19823 9619-9627 JJ denotes specific
T19824 9628-9638 NN denotes signalling
T19825 9639-9647 NN denotes proteins
T19826 9648-9657 VB denotes including
T19827 9658-9662 NN denotes RIP1
T19828 9663-9666 CC denotes and
T19829 9667-9672 NN denotes TRAF6
T19830 9672-9673 -COMMA- denotes ,
T19831 9674-9676 TO denotes to
T19832 9677-9682 WDT denotes which
T19833 9683-9687 PRP denotes they
T19834 9688-9691 VB denotes are
T19835 9692-9701 VB denotes recruited
T19836 9702-9707 VB denotes using
T19837 9708-9716 JJ denotes specific
T19838 9717-9734 JJ denotes ubiquitin-binding
T19839 9735-9742 NN denotes adaptor
T19840 9743-9751 NN denotes proteins
T19841 9752-9756 JJ denotes such
T19842 9757-9759 IN denotes as
T19843 9760-9766 NN denotes ABIN-1
T19844 9767-9770 CC denotes and
T19845 9771-9775 NN denotes p62.
T19846 9776-9783 NN denotes miR-146
T19847 9784-9786 VB denotes is
T19848 9787-9794 VB denotes thought
T19849 9795-9797 TO denotes to
T19850 9798-9808 RB denotes negatively
T19851 9809-9817 VB denotes regulate
T19852 9818-9821 NN denotes TLR
T19853 9822-9832 NN denotes signalling
T19854 9833-9835 IN denotes by
T19855 9836-9846 VB denotes inhibiting
T19856 9847-9857 NN denotes expression
T19857 9858-9860 IN denotes of
T19858 9861-9866 NN denotes IRAK1
T19859 9867-9870 CC denotes and
T19860 9871-9876 NN denotes TRAF6
T19861 9878-9885 RB denotes Finally
T19862 9885-9886 -COMMA- denotes ,
T19863 9887-9890 NN denotes TLR
T19864 9891-9901 NN denotes signalling
T19865 9902-9905 MD denotes can
T19866 9906-9910 RB denotes also
T19867 9911-9913 VB denotes be
T19868 9914-9923 VB denotes inhibited
T19869 9924-9926 IN denotes by
T19870 9927-9930 DT denotes the
T19871 9931-9944 JJ denotes transmembrane
T19872 9945-9952 NN denotes protein
T19873 9953-9959 NN denotes SIGIRR
T19874 9959-9960 -COMMA- denotes ,
T19875 9961-9966 WDT denotes which
T19876 9967-9970 VB denotes has
T19877 9971-9975 VB denotes been
T19878 9976-9984 VB denotes proposed
T19879 9985-9987 TO denotes to
T19880 9988-9995 VB denotes compete
T19881 9996-10000 IN denotes with
T19882 10001-10005 NN denotes TLR4
T19883 10006-10009 IN denotes for
T19884 10010-10017 VB denotes binding
T19885 10018-10020 TO denotes to
T19886 10021-10026 NN denotes IRAK1
T19887 10027-10030 CC denotes and
T19888 10031-10036 NN denotes TRAF6
T19889 10038-10041 DT denotes The
T19890 10042-10052 NN denotes expression
T19891 10053-10055 IN denotes of
T19892 10056-10060 JJ denotes many
T19893 10061-10063 IN denotes of
T19894 10064-10069 DT denotes these
T19895 10070-10078 JJ denotes negative
T19896 10079-10089 JJ denotes regulatory
T19897 10090-10099 NN denotes molecules
T19898 10100-10102 VB denotes is
T19899 10103-10108 NN denotes NF-κB
T19900 10109-10118 JJ denotes dependent
T19901 10118-10119 -COMMA- denotes ,
T19902 10120-10131 VB denotes implicating
T19903 10132-10136 PRP denotes them
T19904 10137-10139 IN denotes in
T19905 10140-10143 DT denotes the
T19906 10144-10152 JJ denotes negative
T19907 10153-10161 NN denotes feedback
T19908 10162-10172 NN denotes regulation
T19909 10173-10175 IN denotes of
T19910 10176-10181 NN denotes NF-κB
T19911 10182-10192 NN denotes activation
T19912 10194-10198 NN denotes ABIN
T19913 10198-10199 -COMMA- denotes ,
T19914 10200-10211 JJ denotes A20-binding
T19915 10212-10221 NN denotes inhibitor
T19916 10222-10224 IN denotes of
T19917 10225-10230 NN denotes NF-κB
T19918 10230-10231 -COLON- denotes ;
T19919 10232-10236 NN denotes cIAP
T19920 10236-10237 -COMMA- denotes ,
T19921 10238-10246 JJ denotes cellular
T19922 10247-10256 NN denotes inhibitor
T19923 10257-10259 IN denotes of
T19924 10260-10269 NN denotes apoptosis
T19925 10269-10270 -COLON- denotes ;
T19926 10271-10275 NN denotes CYLD
T19927 10275-10276 -COMMA- denotes ,
T19928 10277-10292 NN denotes cylindromatosis
T19929 10292-10293 -COLON- denotes ;
T19930 10294-10297 NN denotes IKK
T19931 10297-10298 -COMMA- denotes ,
T19932 10299-10302 NN denotes IκB
T19933 10303-10309 NN denotes kinase
T19934 10309-10310 -COLON- denotes ;
T19935 10311-10314 NN denotes IκB
T19936 10314-10315 -COMMA- denotes ,
T19937 10316-10325 NN denotes inhibitor
T19938 10326-10328 IN denotes of
T19939 10329-10334 NN denotes NF-κB
T19940 10334-10335 -COLON- denotes ;
T19941 10336-10340 NN denotes IRAK
T19942 10340-10341 -COMMA- denotes ,
T19943 10342-10358 JJ denotes IL-1R-associated
T19944 10359-10365 NN denotes kinase
T19945 10365-10366 -COLON- denotes ;
T19946 10367-10372 NN denotes MyD88
T19947 10372-10373 -COMMA- denotes ,
T19948 10374-10381 JJ denotes myeloid
T19949 10382-10397 NN denotes differentiation
T19950 10398-10405 JJ denotes primary
T19951 10406-10414 NN denotes response
T19952 10415-10419 NN denotes gene
T19953 10420-10422 CD denotes 88
T19954 10422-10423 -COLON- denotes ;
T19955 10424-10428 NN denotes NEMO
T19956 10428-10429 -COMMA- denotes ,
T19957 10430-10435 NN denotes NF-κB
T19958 10436-10445 JJ denotes essential
T19959 10446-10455 NN denotes modulator
T19960 10455-10456 -COLON- denotes ;
T19961 10457-10459 NN denotes NF
T19962 10459-10460 -COMMA- denotes ,
T19963 10461-10468 JJ denotes nuclear
T19964 10469-10475 NN denotes factor
T19965 10475-10476 -COLON- denotes ;
T19966 10477-10481 NN denotes RANK
T19967 10481-10482 -COMMA- denotes ,
T19968 10483-10491 NN denotes receptor
T19969 10492-10501 NN denotes activator
T19970 10502-10504 IN denotes of
T19971 10505-10510 NN denotes NF-κB
T19972 10510-10511 -COLON- denotes ;
T19973 10512-10516 NN denotes RIP1
T19974 10516-10517 -COMMA- denotes ,
T19975 10518-10526 NN denotes receptor
T19976 10527-10538 VB denotes interacting
T19977 10539-10546 NN denotes protein
T19978 10547-10548 CD denotes 1
T19979 10548-10549 -COLON- denotes ;
T19980 10550-10556 NN denotes SIGIRR
T19981 10556-10557 -COMMA- denotes ,
T19982 10558-10583 NN denotes single-immunoglobulinIL-1
T19983 10584-10600 JJ denotes receptor-related
T19984 10600-10601 -COLON- denotes ;
T19985 10602-10605 NN denotes TIR
T19986 10605-10606 -COMMA- denotes ,
T19987 10607-10616 JJ denotes Toll-like
T19988 10617-10631 NN denotes receptor/IL-1R
T19989 10631-10632 -COLON- denotes ;
T19990 10633-10637 NN denotes TRAF
T19991 10637-10638 -COMMA- denotes ,
T19992 10639-10642 NN denotes TNF
T19993 10643-10662 JJ denotes receptor-associated
T19994 10663-10669 NN denotes factor
T19995 10669-10670 -COLON- denotes ;
T19996 10671-10674 NN denotes TLR
T19997 10674-10675 -COMMA- denotes ,
T19998 10676-10685 JJ denotes Toll-like
T19999 10686-10694 NN denotes receptor
T20000 10694-10695 -COLON- denotes ;
T20001 10696-10699 NN denotes TNF
T20002 10699-10700 -COMMA- denotes ,
T20003 10701-10707 NN denotes tumour
T20004 10708-10716 NN denotes necrosis
T20005 10717-10723 NN denotes factor
T4842 10725-10728 CD denotes One
T4843 10729-10731 IN denotes of
T4844 10732-10735 DT denotes the
T4845 10736-10740 JJ denotes best
T4846 10741-10748 VB denotes studied
T4847 10749-10754 NN denotes NF-κB
T4848 10755-10765 NN denotes signalling
T4849 10766-10774 NN denotes pathways
T4850 10775-10777 VB denotes is
T4851 10778-10781 DT denotes the
T4852 10782-10785 NN denotes TNF
T4853 10786-10793 NN denotes pathway
T4854 10795-10798 NN denotes TNF
T4855 10799-10810 NN denotes stimulation
T4856 10811-10818 VB denotes results
T4857 10819-10821 IN denotes in
T4858 10822-10825 DT denotes the
T4859 10826-10837 NN denotes recruitment
T4860 10838-10840 IN denotes of
T4861 10841-10844 NN denotes TNF
T4862 10845-10866 JJ denotes receptor-1-associated
T4863 10867-10872 NN denotes death
T4864 10873-10879 NN denotes domain
T4865 10880-10881 -LRB- denotes (
T4866 10881-10886 NN denotes TRADD
T4867 10886-10887 -RRB- denotes )
T4868 10888-10895 NN denotes protein
T4869 10896-10899 CC denotes and
T4870 10900-10902 IN denotes of
T4871 10903-10911 NN denotes receptor
T4872 10912-10923 VB denotes interacting
T4873 10924-10931 NN denotes protein
T4874 10932-10933 CD denotes 1
T4875 10934-10935 -LRB- denotes (
T4876 10935-10939 NN denotes RIP1
T4877 10939-10940 -RRB- denotes )
T4878 10940-10941 -COMMA- denotes ,
T4879 10942-10947 WDT denotes which
T4880 10948-10956 VB denotes function
T4881 10957-10959 IN denotes as
T4882 10960-10967 NN denotes adaptor
T4883 10968-10976 NN denotes proteins
T4884 10977-10980 IN denotes for
T4885 10981-10984 DT denotes the
T4886 10985-10987 NN denotes E3
T4887 10988-10997 NN denotes ubiquitin
T4888 10998-11005 NN denotes ligases
T4889 11006-11009 NN denotes TNF
T4890 11010-11029 JJ denotes receptor-associated
T4891 11030-11036 NN denotes factor
T4892 11037-11038 -LRB- denotes (
T4893 11038-11042 NN denotes TRAF
T4894 11042-11043 -RRB- denotes )
T4895 11044-11045 CD denotes 2
T4896 11046-11049 CC denotes and
T4897 11050-11055 NN denotes TRAF5
T4898 11055-11056 -COMMA- denotes ,
T4899 11057-11062 WDT denotes which
T4900 11063-11065 IN denotes in
T4901 11066-11070 NN denotes turn
T4902 11071-11075 VB denotes bind
T4903 11076-11079 DT denotes the
T4904 11080-11082 NN denotes E3
T4905 11083-11092 NN denotes ubiquitin
T4906 11093-11100 NN denotes ligases
T4907 11101-11109 JJ denotes cellular
T4908 11110-11119 NN denotes inhibitor
T4909 11120-11122 IN denotes of
T4910 11123-11132 NN denotes apoptosis
T4911 11133-11134 -LRB- denotes (
T4912 11134-11138 NN denotes cIAP
T4913 11138-11139 -RRB- denotes )
T4914 11140-11141 CD denotes 1
T4915 11142-11145 CC denotes and
T4916 11146-11151 NN denotes cIAP2
T4917 11152-11153 -LRB- denotes (
T4918 11153-11159 NN denotes Figure
T4919 11160-11161 CD denotes 1
T4920 11161-11162 -RRB- denotes )
T4921 11164-11166 IN denotes On
T4922 11167-11170 NN denotes TNF
T4923 11171-11182 NN denotes stimulation
T4924 11182-11183 -COMMA- denotes ,
T4925 11184-11196 NN denotes TNF-receptor
T4926 11197-11202 VB denotes bound
T4927 11203-11207 NN denotes RIP1
T4928 11208-11210 VB denotes is
T4929 11211-11218 RB denotes rapidly
T4930 11219-11227 VB denotes modified
T4931 11228-11230 IN denotes by
T4932 11231-11241 JJ denotes K63-linked
T4933 11242-11255 NN denotes polyubiquitin
T4934 11256-11262 NN denotes chains
T4935 11264-11271 NN denotes TRAF2/5
T4936 11272-11275 CC denotes and
T4937 11276-11283 NN denotes cIAP1/2
T4938 11284-11287 VB denotes are
T4939 11288-11292 JJ denotes good
T4940 11293-11303 NN denotes candidates
T4941 11304-11307 IN denotes for
T4942 11308-11312 NN denotes RIP1
T4943 11313-11327 NN denotes ubiquitination
T4944 11327-11328 -COMMA- denotes ,
T4945 11329-11332 CC denotes but
T4946 11333-11336 DT denotes the
T4947 11337-11345 JJ denotes specific
T4948 11346-11350 NN denotes role
T4949 11351-11353 IN denotes of
T4950 11354-11358 DT denotes each
T4951 11359-11361 VB denotes is
T4952 11362-11367 RB denotes still
T4953 11368-11375 JJ denotes unclear
T4954 11377-11380 DT denotes The
T4955 11381-11394 NN denotes polyubiquitin
T4956 11395-11401 NN denotes chains
T4957 11402-11404 IN denotes on
T4958 11405-11409 NN denotes RIP1
T4959 11410-11413 VB denotes are
T4960 11414-11422 VB denotes believed
T4961 11423-11425 TO denotes to
T4962 11426-11432 VB denotes create
T4963 11433-11434 DT denotes a
T4964 11435-11443 NN denotes scaffold
T4965 11444-11446 TO denotes to
T4966 11447-11454 VB denotes recruit
T4967 11455-11458 DT denotes the
T4968 11459-11462 NN denotes IKK
T4969 11463-11466 CC denotes and
T4970 11467-11471 NN denotes TAK1
T4971 11472-11479 NN denotes complex
T4972 11480-11483 IN denotes via
T4973 11484-11487 DT denotes the
T4974 11488-11505 JJ denotes ubiquitin-binding
T4975 11506-11514 NN denotes proteins
T4976 11515-11519 NN denotes NEMO
T4977 11520-11523 CC denotes and
T4978 11524-11530 NN denotes TAB1/2
T4979 11530-11531 -COMMA- denotes ,
T4980 11532-11544 RB denotes respectively
T4981 11546-11549 DT denotes The
T4982 11550-11556 JJ denotes recent
T4983 11557-11571 NN denotes identification
T4984 11572-11574 IN denotes of
T4985 11575-11576 DT denotes a
T4986 11577-11585 JJ denotes distinct
T4987 11586-11591 NN denotes E2/E3
T4988 11592-11598 NN denotes enzyme
T4989 11599-11606 NN denotes complex
T4990 11607-11611 WDT denotes that
T4991 11612-11620 VB denotes modifies
T4992 11621-11625 NN denotes NEMO
T4993 11626-11630 IN denotes with
T4994 11631-11637 JJ denotes linear
T4995 11638-11651 NN denotes polyubiquitin
T4996 11652-11658 NN denotes chains
T4997 11659-11662 CC denotes and
T4998 11663-11665 VB denotes is
T4999 11666-11675 JJ denotes essential
T5000 11676-11679 IN denotes for
T5001 11680-11693 JJ denotes TNF-activated
T5002 11694-11699 NN denotes NF-κB
T5003 11700-11710 NN denotes signalling
T5004 11711-11715 VB denotes adds
T5005 11716-11723 JJ denotes further
T5006 11724-11734 NN denotes complexity
T5007 11735-11736 -LRB- denotes [
T5008 11736-11738 CD denotes 22
T5009 11738-11739 -RRB- denotes ]
T5010 11741-11744 DT denotes The
T5011 11745-11750 JJ denotes exact
T5012 11751-11755 NN denotes role
T5013 11756-11758 IN denotes of
T5014 11759-11775 JJ denotes protein-anchored
T5015 11776-11789 NN denotes polyubiquitin
T5016 11790-11796 NN denotes chains
T5017 11797-11804 VB denotes remains
T5018 11805-11812 JJ denotes unclear
T5019 11812-11813 -COMMA- denotes ,
T5020 11814-11816 IN denotes as
T5021 11817-11819 PRP denotes it
T5022 11820-11823 VB denotes was
T5023 11824-11832 RB denotes recently
T5024 11833-11842 VB denotes suggested
T5025 11843-11847 IN denotes that
T5026 11848-11858 JJ denotes unanchored
T5027 11859-11872 NN denotes polyubiquitin
T5028 11873-11879 NN denotes chains
T5029 11880-11883 MD denotes can
T5030 11884-11892 RB denotes directly
T5031 11893-11901 VB denotes activate
T5032 11902-11905 DT denotes the
T5033 11906-11910 NN denotes TAK1
T5034 11911-11918 NN denotes complex
T5035 11919-11920 -LRB- denotes [
T5036 11920-11922 CD denotes 23
T5037 11922-11923 -RRB- denotes ]
T5038 11925-11932 JJ denotes Similar
T5039 11933-11943 NN denotes signalling
T5040 11944-11954 NN denotes principles
T5041 11955-11960 VB denotes apply
T5042 11961-11963 TO denotes to
T5043 11964-11969 JJ denotes other
T5044 11970-11979 NN denotes receptors
T5045 11981-11984 IN denotes For
T5046 11985-11992 NN denotes example
T5047 11992-11993 -COMMA- denotes ,
T5048 11994-11998 NN denotes TLR4
T5049 11999-12010 NN denotes stimulation
T5050 12011-12013 IN denotes by
T5051 12014-12032 NN denotes lipopolysaccharide
T5052 12033-12040 VB denotes induces
T5053 12041-12044 DT denotes the
T5054 12045-12056 NN denotes recruitment
T5055 12057-12059 IN denotes of
T5056 12060-12069 NN denotes Toll/IL-1
T5057 12070-12078 NN denotes receptor
T5058 12079-12086 NN denotes adaptor
T5059 12087-12094 NN denotes protein
T5060 12095-12096 -LRB- denotes (
T5061 12096-12100 RB denotes also
T5062 12101-12109 VB denotes referred
T5063 12110-12112 TO denotes to
T5064 12113-12115 IN denotes as
T5065 12116-12119 NNP denotes Mal
T5066 12119-12120 -RRB- denotes )
T5067 12121-12124 CC denotes and
T5068 12125-12137 JJ denotes TRIF-related
T5069 12138-12145 NN denotes adaptor
T5070 12146-12154 NN denotes molecule
T5071 12155-12156 -LRB- denotes (
T5072 12156-12160 NN denotes TRAM
T5073 12160-12161 -RRB- denotes )
T5074 12161-12162 -COMMA- denotes ,
T5075 12163-12168 WDT denotes which
T5076 12169-12173 RB denotes most
T5077 12174-12182 RB denotes probably
T5078 12183-12188 VB denotes serve
T5079 12189-12191 IN denotes as
T5080 12192-12200 VB denotes bridging
T5081 12201-12208 NN denotes factors
T5082 12209-12211 TO denotes to
T5083 12212-12219 VB denotes recruit
T5084 12220-12227 JJ denotes myeloid
T5085 12228-12243 NN denotes differentiation
T5086 12244-12251 JJ denotes primary
T5087 12252-12260 NN denotes response
T5088 12261-12265 NN denotes gene
T5089 12266-12268 CD denotes 88
T5090 12269-12270 -LRB- denotes (
T5091 12270-12275 NN denotes MyD88
T5092 12275-12276 -RRB- denotes )
T5093 12277-12280 CC denotes and
T5094 12281-12284 NN denotes TIR
T5095 12285-12302 JJ denotes domain-containing
T5096 12303-12319 JJ denotes adaptor-inducing
T5097 12320-12324 NN denotes IFNβ
T5098 12325-12326 -LRB- denotes (
T5099 12326-12330 NN denotes TRIF
T5100 12330-12331 -RRB- denotes )
T5101 12331-12332 -COMMA- denotes ,
T5102 12333-12345 RB denotes respectively
T5103 12347-12352 NN denotes MyD88
T5104 12353-12355 IN denotes in
T5105 12356-12360 NN denotes turn
T5106 12361-12369 VB denotes recruits
T5107 12370-12377 NN denotes members
T5108 12378-12380 IN denotes of
T5109 12381-12384 DT denotes the
T5110 12385-12401 JJ denotes IL-1R-associated
T5111 12402-12408 NN denotes kinase
T5112 12409-12410 -LRB- denotes (
T5113 12410-12414 NN denotes IRAK
T5114 12414-12415 -RRB- denotes )
T5115 12416-12422 NN denotes family
T5116 12423-12426 CC denotes and
T5117 12427-12432 NN denotes TRAF6
T5118 12432-12433 -COMMA- denotes ,
T5119 12434-12441 VB denotes leading
T5120 12442-12444 TO denotes to
T5121 12445-12460 NN denotes oligomerisation
T5122 12461-12464 CC denotes and
T5123 12465-12483 NN denotes selfubiquitination
T5124 12484-12486 IN denotes of
T5125 12487-12492 NN denotes TRAF6
T5126 12493-12494 -LRB- denotes [
T5127 12494-12496 CD denotes 24
T5128 12496-12497 -RRB- denotes ]
T5129 12499-12503 NN denotes TRIF
T5130 12504-12508 RB denotes also
T5131 12509-12517 VB denotes recruits
T5132 12518-12523 NN denotes TRAF6
T5133 12524-12525 -LRB- denotes [
T5134 12525-12527 CD denotes 25
T5135 12527-12528 -RRB- denotes ]
T5136 12529-12532 CC denotes and
T5137 12533-12537 NN denotes RIP1
T5138 12538-12539 -LRB- denotes [
T5139 12539-12541 CD denotes 26
T5140 12541-12542 -RRB- denotes ]
T5141 12543-12546 IN denotes via
T5142 12547-12548 DT denotes a
T5143 12549-12555 JJ denotes direct
T5144 12556-12567 NN denotes interaction
T5145 12569-12573 DT denotes Both
T5146 12574-12582 NN denotes pathways
T5147 12583-12587 RB denotes then
T5148 12588-12596 VB denotes activate
T5149 12597-12601 NN denotes TAK1
T5150 12602-12605 CC denotes and
T5151 12606-12609 NN denotes IKK
T5152 12610-12612 IN denotes in
T5153 12613-12614 DT denotes a
T5154 12615-12639 JJ denotes ubiquitination-dependent
T5155 12640-12646 NN denotes manner
T5156 12647-12654 JJ denotes similar
T5157 12655-12657 TO denotes to
T5158 12658-12661 DT denotes the
T5159 12662-12665 NN denotes TNF
T5160 12666-12673 NN denotes pathway
T5161 12674-12675 -LRB- denotes (
T5162 12675-12681 NN denotes Figure
T5163 12682-12683 CD denotes 1
T5164 12683-12684 -RRB- denotes )
T5165 12686-12689 DT denotes The
T5166 12690-12702 JJ denotes noncanonical
T5167 12703-12708 NN denotes NF-κB
T5168 12709-12716 NN denotes pathway
T5169 12717-12720 MD denotes can
T5170 12721-12723 VB denotes be
T5171 12724-12733 VB denotes activated
T5172 12734-12736 IN denotes by
T5173 12737-12740 DT denotes the
T5174 12741-12752 NN denotes lymphotoxin
T5175 12753-12754 NN denotes β
T5176 12755-12763 NN denotes receptor
T5177 12763-12764 -COMMA- denotes ,
T5178 12765-12769 NN denotes BAFF
T5179 12770-12778 NN denotes receptor
T5180 12778-12779 -COMMA- denotes ,
T5181 12780-12784 NN denotes CD40
T5182 12784-12785 -COMMA- denotes ,
T5183 12786-12789 CC denotes and
T5184 12790-12794 NN denotes RANK
T5185 12795-12796 -LRB- denotes (
T5186 12796-12802 NN denotes Figure
T5187 12803-12804 CD denotes 2
T5188 12804-12805 -RRB- denotes )
T5189 12807-12809 IN denotes In
T5190 12810-12814 DT denotes this
T5191 12815-12822 NN denotes pathway
T5192 12822-12823 -COMMA- denotes ,
T5193 12824-12828 NN denotes p100
T5194 12829-12831 VB denotes is
T5195 12832-12841 VB denotes processed
T5196 12842-12844 IN denotes by
T5197 12845-12848 DT denotes the
T5198 12849-12859 NN denotes proteasome
T5199 12860-12862 TO denotes to
T5200 12863-12866 NN denotes p52
T5201 12866-12867 -COMMA- denotes ,
T5202 12868-12873 WDT denotes which
T5203 12874-12882 RB denotes together
T5204 12883-12887 IN denotes with
T5205 12888-12891 DT denotes the
T5206 12892-12896 NN denotes RelB
T5207 12897-12902 NN denotes NF-κB
T5208 12903-12910 NN denotes subunit
T5209 12911-12920 VB denotes regulates
T5210 12921-12922 DT denotes a
T5211 12923-12931 JJ denotes distinct
T5212 12932-12935 NN denotes set
T5213 12936-12938 IN denotes of
T5214 12939-12945 NN denotes target
T5215 12946-12951 NN denotes genes
T5216 12952-12956 WDT denotes that
T5217 12957-12964 VB denotes control
T5218 12965-12971 NN denotes B-cell
T5219 12972-12983 NN denotes development
T5220 12983-12984 -COMMA- denotes ,
T5221 12985-12994 JJ denotes secondary
T5222 12995-13003 JJ denotes lymphoid
T5223 13004-13009 NN denotes organ
T5224 13010-13021 NN denotes development
T5225 13021-13022 -COMMA- denotes ,
T5226 13023-13026 CC denotes and
T5227 13027-13045 NN denotes osteoclastogenesis
T5228 13046-13047 -LRB- denotes [
T5229 13047-13049 CD denotes 27
T5230 13049-13050 -RRB- denotes ]
T5231 13051-13054 DT denotes The
T5232 13055-13067 JJ denotes noncanonical
T5233 13068-13073 NN denotes NF-κB
T5234 13074-13081 NN denotes pathway
T5235 13082-13084 VB denotes is
T5236 13085-13093 RB denotes strictly
T5237 13094-13103 JJ denotes dependent
T5238 13104-13106 IN denotes on
T5239 13107-13111 NN denotes IKK1
T5240 13111-13112 -COMMA- denotes ,
T5241 13113-13118 WDT denotes which
T5242 13119-13121 VB denotes is
T5243 13122-13131 VB denotes activated
T5244 13132-13136 IN denotes upon
T5245 13137-13152 NN denotes phosphorylation
T5246 13153-13155 IN denotes by
T5247 13156-13161 NN denotes NF-κB
T5248 13162-13170 VB denotes inducing
T5249 13171-13177 NN denotes kinase
T5250 13178-13179 -LRB- denotes (
T5251 13179-13182 NN denotes NIK
T5252 13182-13183 -RRB- denotes )
T5253 13185-13188 NN denotes NIK
T5254 13189-13191 VB denotes is
T5255 13192-13205 RB denotes predominantly
T5256 13206-13215 VB denotes regulated
T5257 13216-13218 IN denotes at
T5258 13219-13222 DT denotes the
T5259 13223-13241 JJ denotes post-translational
T5260 13242-13247 NN denotes level
T5261 13248-13251 CC denotes and
T5262 13252-13254 VB denotes is
T5263 13255-13262 JJ denotes present
T5264 13263-13265 IN denotes at
T5265 13266-13275 RB denotes extremely
T5266 13276-13279 JJ denotes low
T5267 13280-13286 NN denotes levels
T5268 13287-13289 IN denotes in
T5269 13290-13294 JJ denotes most
T5270 13295-13299 NN denotes cell
T5271 13300-13305 NN denotes types
T5272 13307-13309 IN denotes In
T5273 13310-13322 JJ denotes unstimulated
T5274 13323-13328 NN denotes cells
T5275 13328-13329 -COMMA- denotes ,
T5276 13330-13333 NN denotes NIK
T5277 13334-13340 VB denotes occurs
T5278 13341-13343 IN denotes in
T5279 13344-13345 DT denotes a
T5280 13346-13357 JJ denotes cytoplasmic
T5281 13358-13365 NN denotes complex
T5282 13366-13370 IN denotes with
T5283 13371-13376 NN denotes TRAF2
T5284 13376-13377 -COMMA- denotes ,
T5285 13378-13383 NN denotes TRAF3
T5286 13383-13384 -COMMA- denotes ,
T5287 13385-13388 CC denotes and
T5288 13389-13396 NN denotes cIAP1/2
T5289 13396-13397 -COMMA- denotes ,
T5290 13398-13403 WDT denotes which
T5291 13404-13425 VB denotes K48-polyubiquitinates
T5292 13426-13429 NN denotes NIK
T5293 13429-13430 -COMMA- denotes ,
T5294 13431-13438 VB denotes leading
T5295 13439-13441 TO denotes to
T5296 13442-13445 PRP-DOLLAR- denotes its
T5297 13446-13456 JJ denotes continuous
T5298 13457-13468 NN denotes degradation
T5299 13469-13471 IN denotes by
T5300 13472-13475 DT denotes the
T5301 13476-13486 NN denotes proteasome
T5302 13488-13496 NN denotes Receptor
T5303 13497-13505 NN denotes ligation
T5304 13506-13509 VB denotes has
T5305 13510-13514 VB denotes been
T5306 13515-13520 VB denotes shown
T5307 13521-13524 RB denotes not
T5308 13525-13529 RB denotes only
T5309 13530-13532 TO denotes to
T5310 13533-13539 VB denotes remove
T5311 13540-13545 NN denotes TRAF3
T5312 13546-13550 IN denotes from
T5313 13551-13555 DT denotes this
T5314 13556-13563 NN denotes complex
T5315 13564-13566 IN denotes by
T5316 13567-13577 VB denotes recruiting
T5317 13578-13580 PRP denotes it
T5318 13581-13583 TO denotes to
T5319 13584-13587 DT denotes the
T5320 13588-13596 NN denotes receptor
T5321 13596-13597 -COMMA- denotes ,
T5322 13598-13601 CC denotes but
T5323 13602-13606 RB denotes also
T5324 13607-13609 TO denotes to
T5325 13610-13617 VB denotes attract
T5326 13618-13623 NN denotes TRAF2
T5327 13624-13627 CC denotes and
T5328 13628-13635 NN denotes cIAP1/2
T5329 13635-13636 -COMMA- denotes ,
T5330 13637-13642 WDT denotes which
T5331 13643-13646 VB denotes are
T5332 13647-13656 JJ denotes essential
T5333 13657-13660 IN denotes for
T5334 13661-13671 JJ denotes subsequent
T5335 13672-13677 NN denotes TRAF3
T5336 13678-13689 NN denotes degradation
T5337 13691-13694 PDT denotes All
T5338 13695-13699 DT denotes this
T5339 13700-13711 VB denotes contributes
T5340 13712-13714 TO denotes to
T5341 13715-13724 VB denotes releasing
T5342 13725-13728 NN denotes NIK
T5343 13729-13733 IN denotes from
T5344 13734-13737 PRP-DOLLAR- denotes its
T5345 13738-13750 JJ denotes constitutive
T5346 13751-13762 NN denotes degradation
T5347 13762-13763 -COMMA- denotes ,
T5348 13764-13773 VB denotes resulting
T5349 13774-13776 IN denotes in
T5350 13777-13780 NN denotes NIK
T5351 13781-13793 NN denotes accumulation
T5352 13794-13797 CC denotes and
T5353 13798-13802 NN denotes IKK1
T5354 13803-13818 NN denotes phosphorylation
T5355 13819-13820 -LRB- denotes [
T5356 13820-13825 CD denotes 28,29
T5357 13825-13826 -RRB- denotes ]
T5358 13827-13828 -LRB- denotes (
T5359 13828-13834 NN denotes Figure
T5360 13835-13836 CD denotes 2
T5361 13836-13837 -RRB- denotes )
T21532 13849-13861 JJ denotes Noncanonical
T21533 13862-13867 NN denotes NF-κB
T21534 13868-13878 NN denotes signalling
T21535 13880-13884 NN denotes CD40
T21536 13885-13888 CC denotes and
T21537 13889-13893 NN denotes RANK
T21538 13894-13897 MD denotes can
T21539 13898-13906 VB denotes activate
T21540 13907-13910 DT denotes the
T21541 13911-13923 JJ denotes noncanonical
T21542 13924-13929 NN denotes NF-κB
T21543 13930-13937 NN denotes pathway
T21544 13938-13942 WDT denotes that
T21545 13943-13945 VB denotes is
T21546 13946-13955 JJ denotes dependent
T21547 13956-13958 IN denotes on
T21548 13959-13964 NN denotes NF-κB
T21549 13965-13973 VB denotes inducing
T21550 13974-13980 NN denotes kinase
T21551 13981-13982 -LRB- denotes (
T21552 13982-13985 NN denotes NIK
T21553 13985-13986 -RRB- denotes )
T21554 13987-13997 NN denotes expression
T21555 13998-14004 NN denotes levels
T21556 14006-14008 IN denotes In
T21557 14009-14021 JJ denotes unstimulated
T21558 14022-14027 NN denotes cells
T21559 14028-14031 NN denotes NIK
T21560 14032-14037 VB denotes forms
T21561 14038-14039 DT denotes a
T21562 14040-14049 JJ denotes cytosolic
T21563 14050-14057 NN denotes complex
T21564 14058-14062 IN denotes with
T21565 14063-14066 DT denotes the
T21566 14067-14076 NN denotes ubiquitin
T21567 14077-14084 NN denotes ligases
T21568 14085-14090 NN denotes TRAF2
T21569 14090-14091 -COMMA- denotes ,
T21570 14092-14097 NN denotes TRAF3
T21571 14098-14101 CC denotes and
T21572 14102-14109 NN denotes cIAP1/2
T21573 14109-14110 -COMMA- denotes ,
T21574 14111-14116 WDT denotes which
T21575 14117-14128 VB denotes facilitates
T21576 14129-14132 DT denotes the
T21577 14133-14143 JJ denotes K48-linked
T21578 14144-14162 NN denotes polyubiquitination
T21579 14163-14166 CC denotes and
T21580 14167-14178 JJ denotes proteasomal
T21581 14179-14190 NN denotes degradation
T21582 14191-14193 IN denotes of
T21583 14194-14197 NN denotes NIK
T21584 14197-14198 -COMMA- denotes ,
T21585 14199-14206 VB denotes keeping
T21586 14207-14210 NN denotes NIK
T21587 14211-14217 NN denotes levels
T21588 14218-14221 JJ denotes low
T21589 14223-14227 IN denotes Upon
T21590 14228-14234 NN denotes ligand
T21591 14235-14242 NN denotes binding
T21592 14242-14243 -COMMA- denotes ,
T21593 14244-14249 NN denotes TRAF3
T21594 14250-14252 VB denotes is
T21595 14253-14262 VB denotes recruited
T21596 14263-14265 TO denotes to
T21597 14266-14269 DT denotes the
T21598 14270-14278 NN denotes receptor
T21599 14278-14279 -COMMA- denotes ,
T21600 14280-14285 WRB denotes where
T21601 14286-14291 NN denotes TRAF2
T21602 14292-14299 VB denotes directs
T21603 14300-14314 JJ denotes nondegradative
T21604 14315-14325 JJ denotes K63-linked
T21605 14326-14344 NN denotes polyubiquitination
T21606 14345-14347 IN denotes of
T21607 14348-14355 NN denotes cIAP1/2
T21608 14355-14356 -COMMA- denotes ,
T21609 14357-14366 VB denotes resulting
T21610 14367-14369 IN denotes in
T21611 14370-14375 PRP-DOLLAR- denotes their
T21612 14376-14386 NN denotes activation
T21613 14388-14400 RB denotes Subsequently
T21614 14401-14408 NN denotes cIAP1/2
T21615 14409-14416 VB denotes directs
T21616 14417-14420 PRP-DOLLAR- denotes its
T21617 14421-14431 JJ denotes K48-linked
T21618 14432-14450 NN denotes polyubiquitination
T21619 14451-14453 TO denotes to
T21620 14454-14459 NN denotes TRAF3
T21621 14459-14460 -COMMA- denotes ,
T21622 14461-14467 RB denotes rather
T21623 14468-14472 IN denotes than
T21624 14473-14476 NN denotes NIK
T21625 14478-14480 IN denotes As
T21626 14481-14482 DT denotes a
T21627 14483-14489 NN denotes result
T21628 14489-14490 -COMMA- denotes ,
T21629 14491-14496 NN denotes TRAF3
T21630 14497-14499 VB denotes is
T21631 14500-14508 VB denotes degraded
T21632 14509-14512 CC denotes and
T21633 14513-14516 NN denotes NIK
T21634 14517-14519 VB denotes is
T21635 14520-14530 VB denotes stabilised
T21636 14530-14531 -COMMA- denotes ,
T21637 14532-14541 VB denotes resulting
T21638 14542-14544 IN denotes in
T21639 14545-14554 VB denotes increased
T21640 14555-14558 NN denotes NIK
T21641 14559-14565 NN denotes levels
T21642 14566-14568 IN denotes in
T21643 14569-14572 DT denotes the
T21644 14573-14577 NN denotes cell
T21645 14579-14582 NN denotes NIK
T21646 14583-14587 RB denotes then
T21647 14588-14602 VB denotes phosphorylates
T21648 14603-14606 CC denotes and
T21649 14607-14616 VB denotes activates
T21650 14617-14621 NN denotes IKK1
T21651 14621-14622 -COMMA- denotes ,
T21652 14623-14628 WDT denotes which
T21653 14629-14637 VB denotes mediates
T21654 14638-14643 NN denotes NF-κB
T21655 14644-14648 NN denotes p100
T21656 14649-14664 NN denotes phosphorylation
T21657 14666-14670 DT denotes This
T21658 14671-14673 VB denotes is
T21659 14674-14682 VB denotes followed
T21660 14683-14685 IN denotes by
T21661 14686-14696 JJ denotes K48-linked
T21662 14697-14715 NN denotes polyubiquitination
T21663 14716-14719 CC denotes and
T21664 14720-14727 JJ denotes partial
T21665 14728-14739 JJ denotes proteasomal
T21666 14740-14751 NN denotes degradation
T21667 14752-14754 IN denotes of
T21668 14755-14759 NN denotes p100
T21669 14760-14762 TO denotes to
T21670 14763-14766 NN denotes p52
T21671 14766-14767 -COMMA- denotes ,
T21672 14768-14773 WDT denotes which
T21673 14774-14779 VB denotes forms
T21674 14780-14781 DT denotes a
T21675 14782-14793 NN denotes heterodimer
T21676 14794-14798 IN denotes with
T21677 14799-14803 NN denotes RelB
T21678 14804-14806 TO denotes to
T21679 14807-14815 VB denotes activate
T21680 14816-14829 NN denotes transcription
T21681 14831-14835 JJ denotes Next
T21682 14836-14838 TO denotes to
T21683 14839-14844 NN denotes TRAF3
T21684 14844-14845 -COMMA- denotes ,
T21685 14846-14851 NN denotes TRAF1
T21686 14852-14855 VB denotes has
T21687 14856-14860 RB denotes also
T21688 14861-14865 VB denotes been
T21689 14866-14876 VB denotes identified
T21690 14877-14879 IN denotes as
T21691 14880-14881 DT denotes a
T21692 14882-14890 JJ denotes negative
T21693 14891-14900 NN denotes regulator
T21694 14901-14903 IN denotes of
T21695 14904-14908 DT denotes this
T21696 14909-14916 NN denotes pathway
T21697 14916-14917 -COMMA- denotes ,
T21698 14918-14922 RB denotes most
T21699 14923-14931 RB denotes probably
T21700 14932-14934 IN denotes by
T21701 14935-14944 VB denotes competing
T21702 14945-14949 IN denotes with
T21703 14950-14955 JJ denotes other
T21704 14956-14959 NN denotes TNF
T21705 14960-14979 JJ denotes receptor-associated
T21706 14980-14988 NN denotes factors.
T21707 14989-14993 NN denotes cIAP
T21708 14993-14994 -COMMA- denotes ,
T21709 14995-15003 JJ denotes cellular
T21710 15004-15013 NN denotes inhibitor
T21711 15014-15016 IN denotes of
T21712 15017-15026 NN denotes apoptosis
T21713 15026-15027 -COLON- denotes ;
T21714 15028-15031 NN denotes IKK
T21715 15031-15032 -COMMA- denotes ,
T21716 15033-15036 NN denotes IκB
T21717 15037-15043 NN denotes kinase
T21718 15043-15044 -COLON- denotes ;
T21719 15045-15047 NN denotes NF
T21720 15047-15048 -COMMA- denotes ,
T21721 15049-15056 JJ denotes nuclear
T21722 15057-15063 NN denotes factor
T21723 15063-15064 -COLON- denotes ;
T21724 15065-15069 NN denotes RANK
T21725 15069-15070 -COMMA- denotes ,
T21726 15071-15079 NN denotes receptor
T21727 15080-15089 NN denotes activator
T21728 15090-15092 IN denotes of
T21729 15093-15098 NN denotes NF-κB
T21730 15098-15099 -COLON- denotes ;
T21731 15100-15104 NN denotes TRAF
T21732 15104-15105 -COMMA- denotes ,
T21733 15106-15109 NN denotes TNF
T21734 15110-15129 JJ denotes receptor-associated
T21735 15130-15136 NN denotes factor
T21736 15136-15137 -COLON- denotes ;
T21737 15138-15141 NN denotes TNF
T21738 15141-15142 -COMMA- denotes ,
T21739 15143-15149 NN denotes tumour
T21740 15150-15158 NN denotes necrosis
T21741 15159-15165 NN denotes factor
T5362 15167-15169 PRP denotes It
T5363 15170-15176 MD denotes should
T5364 15177-15179 VB denotes be
T5365 15180-15189 VB denotes mentioned
T5366 15190-15194 IN denotes that
T5367 15195-15199 NN denotes CD40
T5368 15199-15200 -COMMA- denotes ,
T5369 15201-15212 NN denotes lymphotoxin
T5370 15213-15214 NN denotes β
T5371 15215-15223 NN denotes receptor
T5372 15224-15227 CC denotes and
T5373 15228-15232 NN denotes RANK
T5374 15233-15240 VB denotes mediate
T5375 15241-15244 DT denotes the
T5376 15245-15255 NN denotes activation
T5377 15256-15258 IN denotes of
T5378 15259-15263 CC denotes both
T5379 15264-15273 JJ denotes canonical
T5380 15274-15277 CC denotes and
T5381 15278-15290 JJ denotes noncanonical
T5382 15291-15296 NN denotes NF-κB
T5383 15297-15307 NN denotes signalling
T5384 15308-15316 NN denotes pathways
T5385 15318-15322 IN denotes Upon
T5386 15323-15330 NN denotes binding
T5387 15331-15333 IN denotes of
T5388 15334-15339 PRP-DOLLAR- denotes their
T5389 15340-15346 NN denotes ligand
T5390 15346-15347 -COMMA- denotes ,
T5391 15348-15352 NN denotes CD40
T5392 15353-15356 CC denotes and
T5393 15357-15361 NN denotes RANK
T5394 15362-15370 VB denotes interact
T5395 15371-15375 IN denotes with
T5396 15376-15383 JJ denotes several
T5397 15384-15388 NN denotes TRAF
T5398 15389-15396 NN denotes members
T5399 15396-15397 -COMMA- denotes ,
T5400 15398-15407 VB denotes including
T5401 15408-15413 NN denotes TRAF1
T5402 15413-15414 -COMMA- denotes ,
T5403 15415-15420 NN denotes TRAF2
T5404 15420-15421 -COMMA- denotes ,
T5405 15422-15427 NN denotes TRAF3
T5406 15427-15428 -COMMA- denotes ,
T5407 15429-15434 NN denotes TRAF5
T5408 15434-15435 -COMMA- denotes ,
T5409 15436-15439 CC denotes and
T5410 15440-15445 NN denotes TRAF6
T5411 15445-15446 -COMMA- denotes ,
T5412 15447-15450 CC denotes and
T5413 15451-15455 DT denotes this
T5414 15456-15461 VB denotes leads
T5415 15462-15464 TO denotes to
T5416 15465-15468 DT denotes the
T5417 15469-15480 NN denotes proteolysis
T5418 15481-15483 IN denotes of
T5419 15484-15488 CC denotes both
T5420 15489-15494 NN denotes TRAF2
T5421 15495-15498 CC denotes and
T5422 15499-15504 NN denotes TRAF3
T5423 15504-15505 -COMMA- denotes ,
T5424 15506-15511 WDT denotes which
T5425 15512-15522 VB denotes represents
T5426 15523-15525 DT denotes an
T5427 15526-15535 JJ denotes important
T5428 15536-15540 NN denotes step
T5429 15541-15543 IN denotes in
T5430 15544-15547 DT denotes the
T5431 15548-15558 NN denotes activation
T5432 15559-15561 IN denotes of
T5433 15562-15565 DT denotes the
T5434 15566-15578 JJ denotes noncanonical
T5435 15579-15586 NN denotes pathway
T5436 15587-15589 IN denotes as
T5437 15590-15599 VB denotes described
T5438 15600-15605 RB denotes above
T5439 15607-15615 JJ denotes Specific
T5440 15616-15620 NN denotes TRAF
T5441 15621-15630 NN denotes molecules
T5442 15631-15634 VB denotes are
T5443 15635-15645 VB denotes associated
T5444 15646-15650 IN denotes with
T5445 15651-15662 VB denotes overlapping
T5446 15663-15666 CC denotes and
T5447 15667-15675 JJ denotes distinct
T5448 15676-15689 JJ denotes CD40-mediated
T5449 15690-15699 NN denotes functions
T5450 15701-15704 IN denotes For
T5451 15705-15712 NN denotes example
T5452 15712-15713 -COMMA- denotes ,
T5453 15714-15716 IN denotes in
T5454 15717-15718 NN denotes B
T5455 15719-15724 NN denotes cells
T5456 15725-15730 NN denotes TRAF6
T5457 15731-15733 VB denotes is
T5458 15734-15742 VB denotes required
T5459 15743-15746 IN denotes for
T5460 15747-15760 JJ denotes CD40-mediated
T5461 15761-15764 NN denotes JNK
T5462 15765-15775 NN denotes activation
T5463 15776-15779 CC denotes and
T5464 15780-15784 NN denotes IL-6
T5465 15785-15795 NN denotes production
T5466 15795-15796 -COMMA- denotes ,
T5467 15797-15802 IN denotes while
T5468 15803-15808 NN denotes TRAF2
T5469 15809-15811 VB denotes is
T5470 15812-15820 VB denotes required
T5471 15821-15824 IN denotes for
T5472 15825-15835 NN denotes activation
T5473 15836-15838 IN denotes of
T5474 15839-15844 NN denotes NF-κB
T5475 15844-15845 -COMMA- denotes ,
T5476 15846-15849 CC denotes and
T5477 15850-15855 NN denotes TRAF3
T5478 15856-15862 VB denotes serves
T5479 15863-15865 IN denotes as
T5480 15866-15867 DT denotes a
T5481 15868-15876 JJ denotes negative
T5482 15877-15886 NN denotes regulator
T5483 15887-15889 IN denotes of
T5484 15890-15894 NN denotes CD40
T5485 15895-15905 NN denotes signalling
T5486 15906-15907 -LRB- denotes [
T5487 15907-15912 CD denotes 30,31
T5488 15912-15913 -RRB- denotes ]
T8426 15962-15967 IN denotes Since
T8427 15968-15973 NN denotes NF-κB
T8428 15974-15984 NN denotes activation
T8429 15985-15987 VB denotes is
T8430 15988-15990 RB denotes so
T8431 15991-15998 JJ denotes crucial
T8432 15999-16001 TO denotes to
T8433 16002-16006 JJ denotes many
T8434 16007-16015 JJ denotes cellular
T8435 16016-16025 NN denotes processes
T8436 16025-16026 -COMMA- denotes ,
T8437 16027-16028 DT denotes a
T8438 16029-16034 JJ denotes tight
T8439 16035-16045 NN denotes regulation
T8440 16046-16048 IN denotes of
T8441 16049-16052 DT denotes the
T8442 16053-16058 NN denotes NF-κB
T8443 16059-16069 NN denotes signalling
T8444 16070-16077 NN denotes pathway
T8445 16078-16081 CC denotes and
T8446 16082-16085 DT denotes the
T8447 16086-16091 NN denotes genes
T8448 16092-16094 PRP denotes it
T8449 16095-16102 VB denotes induces
T8450 16103-16105 VB denotes is
T8451 16106-16108 DT denotes an
T8452 16109-16117 JJ denotes absolute
T8453 16118-16129 NN denotes requirement
T8454 16130-16132 TO denotes to
T8455 16133-16142 VB denotes fine-tune
T8456 16143-16146 DT denotes the
T8457 16147-16159 JJ denotes inflammatory
T8458 16160-16168 NN denotes response
T8459 16170-16178 RB denotes Moreover
T8460 16178-16179 -COMMA- denotes ,
T8461 16180-16191 VB denotes terminating
T8462 16192-16194 DT denotes an
T8463 16195-16200 NN denotes NF-κB
T8464 16201-16209 NN denotes response
T8465 16210-16212 VB denotes is
T8466 16213-16222 JJ denotes essential
T8467 16223-16225 TO denotes to
T8468 16226-16233 VB denotes prevent
T8469 16234-16244 JJ denotes persistent
T8470 16245-16250 NN denotes NF-κB
T8471 16251-16261 NN denotes activation
T8472 16262-16266 WDT denotes that
T8473 16267-16270 MD denotes may
T8474 16271-16275 VB denotes lead
T8475 16276-16278 TO denotes to
T8476 16279-16286 JJ denotes chronic
T8477 16287-16299 NN denotes inflammation
T8478 16300-16306 CC denotes and/or
T8479 16307-16320 NN denotes tumorigenesis
T8480 16322-16324 TO denotes To
T8481 16325-16332 VB denotes achieve
T8482 16333-16337 DT denotes this
T8483 16337-16338 -COMMA- denotes ,
T8484 16339-16344 NN denotes cells
T8485 16345-16351 VB denotes employ
T8486 16352-16361 JJ denotes different
T8487 16362-16372 NN denotes mechanisms
T8488 16372-16373 -COMMA- denotes ,
T8489 16374-16383 VB denotes including
T8490 16384-16387 DT denotes the
T8491 16388-16398 NN denotes expression
T8492 16399-16401 IN denotes of
T8493 16402-16412 JJ denotes inhibitory
T8494 16413-16421 NN denotes proteins
T8495 16422-16426 WDT denotes that
T8496 16427-16439 VB denotes downregulate
T8497 16440-16445 NN denotes NF-κB
T8498 16446-16456 NN denotes signalling
T8499 16457-16458 -LRB- denotes [
T8500 16458-16460 CD denotes 32
T8501 16460-16461 -RRB- denotes ]
T8502 16463-16468 IN denotes Below
T8503 16469-16471 PRP denotes we
T8504 16472-16476 VB denotes give
T8505 16477-16479 DT denotes an
T8506 16480-16488 NN denotes overview
T8507 16489-16491 IN denotes of
T8508 16492-16493 DT denotes a
T8509 16494-16500 NN denotes number
T8510 16501-16503 IN denotes of
T8511 16504-16512 NN denotes proteins
T8512 16513-16517 WDT denotes that
T8513 16518-16521 VB denotes are
T8514 16522-16530 VB denotes involved
T8515 16531-16533 IN denotes in
T8516 16534-16537 DT denotes the
T8517 16538-16547 NN denotes dampening
T8518 16548-16550 CC denotes or
T8519 16551-16562 NN denotes termination
T8520 16563-16565 IN denotes of
T8521 16566-16569 DT denotes the
T8522 16570-16575 NN denotes NF-κB
T8523 16576-16584 NN denotes response
T8524 16584-16585 -COMMA- denotes ,
T8525 16586-16590 DT denotes some
T8526 16591-16593 IN denotes of
T8527 16594-16598 PRP denotes them
T8528 16599-16604 IN denotes under
T8529 16605-16608 DT denotes the
T8530 16609-16616 NN denotes control
T8531 16617-16619 IN denotes of
T8532 16620-16625 NN denotes NF-κB
T8533 16626-16632 PRP denotes itself
T8534 16633-16636 CC denotes and
T8535 16637-16641 RB denotes thus
T8536 16642-16648 VB denotes acting
T8537 16649-16651 IN denotes in
T8538 16652-16653 DT denotes a
T8539 16654-16662 JJ denotes negative
T8540 16663-16671 NN denotes feedback
T8541 16672-16676 NN denotes loop
T8542 16678-16680 IN denotes In
T8543 16681-16689 NN denotes addition
T8544 16689-16690 -COMMA- denotes ,
T8545 16691-16693 PRP denotes we
T8546 16694-16701 VB denotes discuss
T8547 16702-16705 DT denotes the
T8548 16706-16715 JJ denotes potential
T8549 16716-16720 NN denotes role
T8550 16721-16723 IN denotes of
T8551 16724-16729 DT denotes these
T8552 16730-16735 NN denotes NF-κB
T8553 16736-16746 JJ denotes inhibitory
T8554 16747-16754 NN denotes factors
T8555 16755-16757 IN denotes in
T8556 16758-16761 DT denotes the
T8557 16762-16777 NN denotes immunopathology
T8558 16778-16780 IN denotes of
T8559 16781-16783 NN denotes RA
T8560 16785-16792 JJ denotes Several
T8561 16793-16798 JJ denotes other
T8562 16799-16807 NN denotes proteins
T8563 16808-16816 VB denotes involved
T8564 16817-16819 IN denotes in
T8565 16820-16823 DT denotes the
T8566 16824-16832 JJ denotes negative
T8567 16833-16843 NN denotes regulation
T8568 16844-16846 IN denotes of
T8569 16847-16862 JJ denotes NF-κB-dependent
T8570 16863-16875 JJ denotes inflammatory
T8571 16876-16885 NN denotes responses
T8572 16885-16886 -COMMA- denotes ,
T8573 16887-16891 JJ denotes such
T8574 16892-16894 IN denotes as
T8575 16895-16901 NN denotes MyD88s
T8576 16901-16902 -COMMA- denotes ,
T8577 16903-16909 NN denotes IRAK-M
T8578 16909-16910 -COMMA- denotes ,
T8579 16911-16914 CC denotes and
T8580 16915-16921 NN denotes TOLLIP
T8581 16921-16922 -COMMA- denotes ,
T8582 16923-16927 VB denotes have
T8583 16928-16932 VB denotes been
T8584 16933-16942 VB denotes described
T8585 16943-16944 -LRB- denotes (
T8586 16944-16952 VB denotes reviewed
T8587 16953-16955 IN denotes in
T8588 16956-16957 -LRB- denotes [
T8589 16957-16959 CD denotes 33
T8590 16959-16960 -RRB- denotes ]
T8591 16960-16961 -RRB- denotes )
T8592 16963-16968 DT denotes These
T8593 16969-16977 NN denotes proteins
T8594 16978-16981 VB denotes are
T8595 16982-16985 RB denotes not
T8596 16986-16995 VB denotes discussed
T8597 16996-17000 RB denotes here
T8598 17000-17001 -COMMA- denotes ,
T8599 17002-17007 IN denotes since
T8600 17008-17009 DT denotes a
T8601 17010-17014 NN denotes link
T8602 17015-17019 IN denotes with
T8603 17020-17022 NN denotes RA
T8604 17023-17032 NN denotes pathology
T8605 17033-17036 VB denotes has
T8606 17037-17040 RB denotes not
T8607 17041-17044 RB denotes yet
T8608 17045-17049 VB denotes been
T8609 17050-17068 IN denotes reported. Although
T8610 17069-17073 NN denotes IKK1
T8611 17074-17076 VB denotes is
T8612 17077-17078 DT denotes a
T8613 17079-17087 JJ denotes critical
T8614 17088-17097 NN denotes component
T8615 17098-17100 IN denotes of
T8616 17101-17104 DT denotes the
T8617 17105-17118 JJ denotes non-canonical
T8618 17119-17124 NN denotes NF-κB
T8619 17125-17132 NN denotes pathway
T8620 17132-17133 -COMMA- denotes ,
T8621 17134-17136 PRP denotes it
T8622 17137-17143 MD denotes should
T8623 17144-17146 VB denotes be
T8624 17147-17156 VB denotes mentioned
T8625 17157-17161 IN denotes that
T8626 17162-17166 DT denotes this
T8627 17167-17173 NN denotes kinase
T8628 17174-17178 RB denotes also
T8629 17179-17184 VB denotes plays
T8630 17185-17186 DT denotes a
T8631 17187-17196 JJ denotes prominent
T8632 17197-17201 NN denotes role
T8633 17202-17204 IN denotes in
T8634 17205-17208 DT denotes the
T8635 17209-17217 JJ denotes negative
T8636 17218-17228 NN denotes regulation
T8637 17229-17231 IN denotes of
T8638 17232-17236 CC denotes both
T8639 17237-17246 JJ denotes canonical
T8640 17247-17250 CC denotes and
T8641 17251-17263 JJ denotes noncanonical
T8642 17264-17269 NN denotes NF-κB
T8643 17270-17278 NN denotes pathways
T8644 17280-17291 NN denotes Macrophages
T8645 17292-17296 IN denotes from
T8646 17297-17311 JJ denotes IKK1-deficient
T8647 17312-17316 NN denotes mice
T8648 17317-17319 CC denotes or
T8649 17320-17327 JJ denotes knockin
T8650 17328-17332 NN denotes mice
T8651 17333-17343 VB denotes expressing
T8652 17344-17352 JJ denotes inactive
T8653 17353-17357 NN denotes IKK1
T8654 17358-17362 VB denotes show
T8655 17363-17372 VB denotes increased
T8656 17373-17383 NN denotes production
T8657 17384-17386 IN denotes of
T8658 17387-17402 JJ denotes proinflammatory
T8659 17403-17412 NN denotes cytokines
T8660 17413-17415 IN denotes as
T8661 17416-17417 DT denotes a
T8662 17418-17424 NN denotes result
T8663 17425-17427 IN denotes of
T8664 17428-17436 VB denotes enhanced
T8665 17437-17441 NN denotes IKK2
T8666 17442-17452 NN denotes activation
T8667 17453-17456 CC denotes and
T8668 17457-17461 NN denotes IκBα
T8669 17462-17473 NN denotes degradation
T8670 17474-17475 -LRB- denotes [
T8671 17475-17477 CD denotes 34
T8672 17477-17478 -RRB- denotes ]
T8673 17480-17484 NN denotes IKK1
T8674 17485-17488 VB denotes has
T8675 17489-17493 RB denotes also
T8676 17494-17498 VB denotes been
T8677 17499-17504 VB denotes shown
T8678 17505-17507 TO denotes to
T8679 17508-17515 VB denotes inhibit
T8680 17516-17523 JJ denotes nuclear
T8681 17524-17529 NN denotes NF-κB
T8682 17530-17533 CC denotes and
T8683 17534-17536 TO denotes to
T8684 17537-17549 VB denotes downregulate
T8685 17550-17565 JJ denotes proinflammatory
T8686 17566-17576 NN denotes signalling
T8687 17577-17579 IN denotes by
T8688 17580-17595 VB denotes phosphorylating
T8689 17596-17601 NN denotes STAT1
T8690 17602-17603 -LRB- denotes [
T8691 17603-17605 CD denotes 35
T8692 17605-17606 -RRB- denotes ]
T8693 17608-17621 RB denotes Interestingly
T8694 17621-17622 -COMMA- denotes ,
T8695 17623-17624 DT denotes a
T8696 17625-17631 JJ denotes recent
T8697 17632-17637 NN denotes study
T8698 17638-17641 VB denotes has
T8699 17642-17654 VB denotes demonstrated
T8700 17655-17659 IN denotes that
T8701 17660-17664 NN denotes IKK1
T8702 17665-17679 VB denotes phosphorylates
T8703 17680-17683 NN denotes NIK
T8704 17684-17686 IN denotes in
T8705 17687-17695 JJ denotes negative
T8706 17696-17704 NN denotes feedback
T8707 17705-17715 NN denotes regulation
T8708 17716-17718 IN denotes of
T8709 17719-17722 DT denotes the
T8710 17723-17735 JJ denotes noncanonical
T8711 17736-17741 NN denotes NF-κB
T8712 17742-17749 NN denotes pathway
T8713 17750-17751 -LRB- denotes [
T8714 17751-17753 CD denotes 36
T8715 17753-17754 -RRB- denotes ]
T8716 17754-17755 -COMMA- denotes ,
T8717 17756-17766 VB denotes supporting
T8718 17767-17770 DT denotes the
T8719 17771-17775 NN denotes idea
T8720 17776-17780 IN denotes that
T8721 17781-17785 NN denotes IKK1
T8722 17786-17791 VB denotes plays
T8723 17792-17801 JJ denotes important
T8724 17802-17807 NN denotes roles
T8725 17808-17810 IN denotes in
T8726 17811-17822 VB denotes terminating
T8727 17823-17827 CC denotes both
T8728 17828-17837 JJ denotes canonical
T8729 17838-17841 CC denotes and
T8730 17842-17854 JJ denotes noncanonical
T8731 17855-17860 NN denotes NF-κB
T8732 17861-17869 NN denotes pathways
T8733 17870-17874 IN denotes with
T8734 17875-17883 JJ denotes possible
T8735 17884-17896 NN denotes implications
T8736 17897-17900 IN denotes for
T8737 17901-17908 JJ denotes chronic
T8738 17909-17921 JJ denotes inflammatory
T8739 17922-17930 NN denotes diseases
T8740 17931-17935 IN denotes like
T8741 17936-17938 NN denotes RA
T9821 17941-17944 NN denotes A20
T9822 17945-17952 NN denotes protein
T9823 17953-17956 NN denotes A20
T9824 17957-17958 -LRB- denotes (
T9825 17958-17962 RB denotes also
T9826 17963-17968 VB denotes known
T9827 17969-17971 IN denotes as
T9828 17972-17979 NN denotes TNFAIP3
T9829 17979-17980 -RRB- denotes )
T9830 17981-17983 VB denotes is
T9831 17984-17985 DT denotes a
T9832 17986-18003 JJ denotes ubiquitin-editing
T9833 18004-18011 NN denotes protein
T9834 18012-18016 WDT denotes that
T9835 18017-18027 RB denotes negatively
T9836 18028-18037 VB denotes regulates
T9837 18038-18053 JJ denotes NF-κB-dependent
T9838 18054-18058 NN denotes gene
T9839 18059-18069 NN denotes expression
T9840 18070-18072 IN denotes in
T9841 18073-18081 NN denotes response
T9842 18082-18084 TO denotes to
T9843 18085-18094 JJ denotes different
T9844 18095-18112 JJ denotes immune-activating
T9845 18113-18120 NN denotes stimuli
T9846 18120-18121 -COMMA- denotes ,
T9847 18122-18131 VB denotes including
T9848 18132-18135 NN denotes TNF
T9849 18135-18136 -COMMA- denotes ,
T9850 18137-18141 NN denotes IL-1
T9851 18142-18145 CC denotes and
T9852 18146-18154 NN denotes antigens
T9853 18154-18155 -COMMA- denotes ,
T9854 18156-18159 CC denotes and
T9855 18160-18163 DT denotes the
T9856 18164-18174 NN denotes triggering
T9857 18175-18177 IN denotes of
T9858 18178-18182 NN denotes TLRs
T9859 18183-18186 CC denotes and
T9860 18187-18190 DT denotes the
T9861 18191-18209 JJ denotes nucleotide-binding
T9862 18210-18225 NN denotes oligomerisation
T9863 18226-18243 JJ denotes domain-containing
T9864 18244-18245 CD denotes 2
T9865 18246-18254 NN denotes receptor
T9866 18255-18256 -LRB- denotes (
T9867 18256-18264 VB denotes reviewed
T9868 18265-18267 IN denotes in
T9869 18268-18269 -LRB- denotes [
T9870 18269-18271 CD denotes 37
T9871 18271-18272 -RRB- denotes ]
T9872 18272-18273 -RRB- denotes )
T9873 18275-18278 NN denotes A20
T9874 18279-18281 VB denotes is
T9875 18282-18290 VB denotes believed
T9876 18291-18293 TO denotes to
T9877 18294-18301 VB denotes inhibit
T9878 18302-18307 NN denotes NF-κB
T9879 18308-18316 NN denotes function
T9880 18317-18319 IN denotes by
T9881 18320-18336 VB denotes deubiquitinating
T9882 18337-18345 JJ denotes specific
T9883 18346-18351 NN denotes NF-κB
T9884 18352-18362 NN denotes signalling
T9885 18363-18372 NN denotes molecules
T9886 18372-18373 -COMMA- denotes ,
T9887 18374-18378 JJ denotes such
T9888 18379-18381 IN denotes as
T9889 18382-18386 NN denotes RIP1
T9890 18386-18387 -COMMA- denotes ,
T9891 18388-18392 NN denotes RIP2
T9892 18392-18393 -COMMA- denotes ,
T9893 18394-18399 NN denotes TRAF6
T9894 18400-18403 CC denotes and
T9895 18404-18409 NN denotes MALT1
T9896 18409-18410 -COMMA- denotes ,
T9897 18411-18416 WDT denotes which
T9898 18417-18425 VB denotes disrupts
T9899 18426-18434 JJ denotes specific
T9900 18435-18450 JJ denotes protein-protein
T9901 18451-18463 NN denotes interactions
T9902 18464-18465 -LRB- denotes [
T9903 18465-18470 CD denotes 38-41
T9904 18470-18471 -RRB- denotes ]
T9905 18472-18473 -LRB- denotes (
T9906 18473-18479 NN denotes Figure
T9907 18480-18481 CD denotes 1
T9908 18481-18482 -RRB- denotes )
T9909 18484-18492 RB denotes Recently
T9910 18492-18493 -COMMA- denotes ,
T9911 18494-18497 DT denotes the
T9912 18498-18508 NN denotes disruption
T9913 18509-18511 IN denotes of
T9914 18512-18524 NN denotes interactions
T9915 18525-18532 IN denotes between
T9916 18533-18535 NN denotes E2
T9917 18536-18545 NN denotes ubiquitin
T9918 18546-18557 VB denotes conjugating
T9919 18558-18565 NN denotes enzymes
T9920 18566-18567 -LRB- denotes (
T9921 18567-18572 NN denotes Ubc13
T9922 18573-18576 CC denotes and
T9923 18577-18583 NN denotes Ubc5hc
T9924 18583-18584 -RRB- denotes )
T9925 18585-18588 CC denotes and
T9926 18589-18591 NN denotes E3
T9927 18592-18601 NN denotes ubiquitin
T9928 18602-18609 NN denotes ligases
T9929 18610-18611 -LRB- denotes (
T9930 18611-18616 NN denotes TRAF6
T9931 18616-18617 -COMMA- denotes ,
T9932 18618-18623 NN denotes TRAF2
T9933 18624-18627 CC denotes and
T9934 18628-18635 NN denotes cIAP1/2
T9935 18635-18636 -RRB- denotes )
T9936 18637-18641 VB denotes were
T9937 18642-18651 VB denotes described
T9938 18652-18654 IN denotes as
T9939 18655-18662 DT denotes another
T9940 18663-18672 JJ denotes important
T9941 18673-18682 NN denotes mechanism
T9942 18683-18687 VB denotes used
T9943 18688-18690 IN denotes by
T9944 18691-18694 NN denotes A20
T9945 18695-18697 TO denotes to
T9946 18698-18710 VB denotes downregulate
T9947 18711-18716 NN denotes NF-κB
T9948 18717-18727 NN denotes signalling
T9949 18728-18729 -LRB- denotes [
T9950 18729-18731 CD denotes 42
T9951 18731-18732 -RRB- denotes ]
T9952 18734-18737 DT denotes The
T9953 18738-18749 NN denotes association
T9954 18750-18752 IN denotes of
T9955 18753-18756 NN denotes A20
T9956 18757-18761 IN denotes with
T9957 18762-18765 PRP-DOLLAR- denotes its
T9958 18766-18773 NN denotes targets
T9959 18774-18782 VB denotes requires
T9960 18783-18791 JJ denotes specific
T9961 18792-18809 JJ denotes ubiquitin-binding
T9962 18810-18817 NN denotes adaptor
T9963 18818-18826 NN denotes proteins
T9964 18826-18827 -COMMA- denotes ,
T9965 18828-18837 VB denotes including
T9966 18838-18849 JJ denotes A20-binding
T9967 18850-18859 NN denotes inhibitor
T9968 18860-18862 IN denotes of
T9969 18863-18868 NN denotes NF-κB
T9970 18869-18870 -LRB- denotes (
T9971 18870-18874 NN denotes ABIN
T9972 18874-18875 -RRB- denotes )
T9973 18876-18877 CD denotes 1
T9974 18878-18881 CC denotes and
T9975 18882-18894 JJ denotes Tax1-binding
T9976 18895-18902 NN denotes protein
T9977 18903-18904 CD denotes 1
T9978 18905-18906 -LRB- denotes [
T9979 18906-18911 CD denotes 43-46
T9980 18911-18912 -RRB- denotes ]
T9981 18914-18918 JJ denotes Next
T9982 18919-18921 TO denotes to
T9983 18922-18925 PRP-DOLLAR- denotes its
T9984 18926-18930 NN denotes role
T9985 18931-18933 IN denotes in
T9986 18934-18945 VB denotes suppressing
T9987 18946-18951 NN denotes NF-κB
T9988 18952-18962 NN denotes activation
T9989 18962-18963 -COMMA- denotes ,
T9990 18964-18967 NN denotes A20
T9991 18968-18970 VB denotes is
T9992 18971-18975 RB denotes also
T9993 18976-18977 DT denotes a
T9994 18978-18984 JJ denotes strong
T9995 18985-18994 NN denotes inhibitor
T9996 18995-18997 IN denotes of
T9997 18998-19007 NN denotes apoptosis
T9998 19007-19008 -COMMA- denotes ,
T9999 19009-19011 IN denotes at
T10000 19012-19017 JJ denotes least
T10001 19018-19020 IN denotes in
T10002 19021-19025 DT denotes some
T10003 19026-19030 NN denotes cell
T10004 19031-19036 NN denotes types
T10005 19038-19041 DT denotes The
T10006 19042-19052 NN denotes mechanisms
T10007 19053-19055 IN denotes by
T10008 19056-19061 WDT denotes which
T10009 19062-19065 NN denotes A20
T10010 19066-19075 VB denotes regulates
T10011 19076-19085 JJ denotes apoptotic
T10012 19086-19096 NN denotes signalling
T10013 19096-19097 -COMMA- denotes ,
T10014 19098-19105 RB denotes however
T10015 19105-19106 -COMMA- denotes ,
T10016 19107-19110 VB denotes are
T10017 19111-19116 RB denotes still
T10018 19117-19124 JJ denotes elusive
T10019 19126-19139 JJ denotes A20-deficient
T10020 19140-19144 NN denotes mice
T10021 19145-19158 RB denotes spontaneously
T10022 19159-19166 VB denotes develop
T10023 19167-19177 JJ denotes multiorgan
T10024 19178-19190 NN denotes inflammation
T10025 19191-19194 CC denotes and
T10026 19195-19203 NN denotes cachexia
T10027 19204-19207 CC denotes and
T10028 19208-19211 VB denotes die
T10029 19212-19218 IN denotes within
T10030 19219-19220 CD denotes 2
T10031 19221-19226 NN denotes weeks
T10032 19227-19229 IN denotes of
T10033 19230-19235 NN denotes birth
T10034 19235-19236 -COMMA- denotes ,
T10035 19237-19249 VB denotes illustrating
T10036 19250-19253 DT denotes the
T10037 19254-19260 JJ denotes potent
T10038 19261-19278 JJ denotes anti-inflammatory
T10039 19279-19287 NN denotes function
T10040 19288-19290 IN denotes of
T10041 19291-19295 DT denotes this
T10042 19296-19304 NN denotes molecule
T10043 19305-19306 -LRB- denotes [
T10044 19306-19308 CD denotes 46
T10045 19308-19309 -RRB- denotes ]
T10046 19311-19324 JJ denotes A20-deficient
T10047 19325-19330 NN denotes cells
T10048 19331-19334 VB denotes are
T10049 19335-19339 RB denotes also
T10050 19340-19344 RB denotes more
T10051 19345-19356 JJ denotes susceptible
T10052 19357-19359 TO denotes to
T10053 19360-19372 JJ denotes TNF-mediated
T10054 19373-19382 NN denotes apoptosis
T10055 19382-19383 -COMMA- denotes ,
T10056 19384-19394 VB denotes confirming
T10057 19395-19398 PRP-DOLLAR- denotes its
T10058 19399-19403 NN denotes role
T10059 19404-19406 IN denotes as
T10060 19407-19409 DT denotes an
T10061 19410-19423 JJ denotes antiapoptotic
T10062 19424-19431 NN denotes protein
T10063 19433-19435 PRP denotes We
T10064 19436-19444 RB denotes recently
T10065 19445-19451 VB denotes showed
T10066 19452-19456 IN denotes that
T10067 19457-19461 NN denotes mice
T10068 19462-19474 RB denotes specifically
T10069 19475-19482 VB denotes lacking
T10070 19483-19486 NN denotes A20
T10071 19487-19489 IN denotes in
T10072 19490-19500 JJ denotes intestinal
T10073 19501-19511 JJ denotes epithelial
T10074 19512-19517 NN denotes cells
T10075 19518-19525 VB denotes exhibit
T10076 19526-19535 VB denotes increased
T10077 19536-19550 NN denotes susceptibility
T10078 19551-19553 TO denotes to
T10079 19554-19566 JJ denotes experimental
T10080 19567-19574 NN denotes colitis
T10081 19575-19578 JJ denotes due
T10082 19579-19581 TO denotes to
T10083 19582-19585 DT denotes the
T10084 19586-19602 NN denotes hypersensitivity
T10085 19603-19605 IN denotes of
T10086 19606-19611 PRP-DOLLAR- denotes their
T10087 19612-19622 JJ denotes intestinal
T10088 19623-19633 JJ denotes epithelial
T10089 19634-19639 NN denotes cells
T10090 19640-19642 TO denotes to
T10091 19643-19654 JJ denotes TNF-induced
T10092 19655-19664 NN denotes apoptosis
T10093 19664-19665 -COMMA- denotes ,
T10094 19666-19676 VB denotes confirming
T10095 19677-19680 NN denotes A20
T10096 19681-19683 IN denotes as
T10097 19684-19685 DT denotes a
T10098 19686-19691 JJ denotes major
T10099 19692-19705 JJ denotes antiapoptotic
T10100 19706-19713 NN denotes protein
T10101 19714-19716 IN denotes in
T10102 19717-19720 DT denotes the
T10103 19721-19731 JJ denotes intestinal
T10104 19732-19742 NN denotes epithelium
T10105 19743-19744 -LRB- denotes [
T10106 19744-19746 CD denotes 47
T10107 19746-19747 -RRB- denotes ]
T10108 19749-19752 CD denotes Two
T10109 19753-19764 JJ denotes independent
T10110 19765-19772 NN denotes studies
T10111 19773-19779 VB denotes showed
T10112 19780-19784 IN denotes that
T10113 19785-19789 NN denotes mice
T10114 19790-19797 VB denotes lacking
T10115 19798-19801 NN denotes A20
T10116 19802-19804 IN denotes in
T10117 19805-19806 NN denotes B
T10118 19807-19812 NN denotes cells
T10119 19813-19820 VB denotes develop
T10120 19821-19833 NN denotes autoimmunity
T10121 19834-19837 JJ denotes due
T10122 19838-19840 TO denotes to
T10123 19841-19852 JJ denotes hyperactive
T10124 19853-19858 NN denotes NF-κB
T10125 19859-19868 NN denotes responses
T10126 19869-19871 IN denotes in
T10127 19872-19873 NN denotes B
T10128 19874-19879 NN denotes cells
T10129 19880-19887 VB denotes leading
T10130 19888-19890 TO denotes to
T10131 19891-19903 JJ denotes unrestricted
T10132 19904-19910 NN denotes B-cell
T10133 19911-19919 NN denotes survival
T10134 19920-19921 -LRB- denotes [
T10135 19921-19926 CD denotes 48,49
T10136 19926-19927 -RRB- denotes ]
T10137 19929-19932 NN denotes A20
T10138 19933-19943 NN denotes expression
T10139 19944-19947 VB denotes has
T10140 19948-19952 VB denotes been
T10141 19953-19961 VB denotes observed
T10142 19962-19964 IN denotes in
T10143 19965-19972 JJ denotes several
T10144 19973-19977 NN denotes cell
T10145 19978-19983 NN denotes types
T10146 19984-19988 WDT denotes that
T10147 19989-19993 VB denotes play
T10148 19994-20003 JJ denotes important
T10149 20004-20009 NN denotes roles
T10150 20010-20012 IN denotes in
T10151 20013-20016 DT denotes the
T10152 20017-20032 NN denotes pathophysiology
T10153 20033-20035 IN denotes of
T10154 20036-20038 NN denotes RA
T10155 20038-20039 -COMMA- denotes ,
T10156 20040-20044 JJ denotes such
T10157 20045-20047 IN denotes as
T10158 20048-20059 NN denotes fibroblasts
T10159 20059-20060 -COMMA- denotes ,
T10160 20061-20073 NN denotes synoviocytes
T10161 20074-20077 CC denotes and
T10162 20078-20089 NN denotes lymphocytes
T10163 20091-20104 RB denotes Interestingly
T10164 20104-20105 -COMMA- denotes ,
T10165 20106-20109 NN denotes A20
T10166 20110-20120 NN denotes expression
T10167 20121-20123 VB denotes is
T10168 20124-20130 PRP denotes itself
T10169 20131-20140 VB denotes regulated
T10170 20141-20143 IN denotes by
T10171 20144-20149 NN denotes NF-κB
T10172 20150-20151 -LRB- denotes [
T10173 20151-20153 CD denotes 50
T10174 20153-20154 -RRB- denotes ]
T10175 20154-20155 -COMMA- denotes ,
T10176 20156-20167 VB denotes implicating
T10177 20168-20171 NN denotes A20
T10178 20172-20174 IN denotes in
T10179 20175-20178 DT denotes the
T10180 20179-20187 JJ denotes negative
T10181 20188-20196 NN denotes feedback
T10182 20197-20207 NN denotes regulation
T10183 20208-20210 IN denotes of
T10184 20211-20216 NN denotes NF-κB
T10185 20217-20227 NN denotes signalling
T10186 20229-20237 RB denotes Recently
T10187 20237-20238 -COMMA- denotes ,
T10188 20239-20254 JJ denotes intra-articular
T10189 20255-20264 NN denotes injection
T10190 20265-20267 IN denotes of
T10191 20268-20270 DT denotes an
T10192 20271-20285 JJ denotes A20-expressing
T10193 20286-20296 NN denotes adenovirus
T10194 20297-20300 VB denotes was
T10195 20301-20306 VB denotes shown
T10196 20307-20309 TO denotes to
T10197 20310-20316 VB denotes reduce
T10198 20317-20320 DT denotes the
T10199 20321-20329 NN denotes severity
T10200 20330-20332 IN denotes of
T10201 20333-20341 JJ denotes synovial
T10202 20342-20354 NN denotes inflammation
T10203 20355-20358 CC denotes and
T10204 20359-20364 JJ denotes joint
T10205 20365-20376 NN denotes destruction
T10206 20377-20379 IN denotes in
T10207 20380-20381 DT denotes a
T10208 20382-20387 NN denotes mouse
T10209 20388-20393 NN denotes model
T10210 20394-20396 IN denotes of
T10211 20397-20413 JJ denotes collagen-induced
T10212 20414-20423 NN denotes arthritis
T10213 20423-20424 -COMMA- denotes ,
T10214 20425-20429 RB denotes even
T10215 20430-20432 IN denotes in
T10216 20433-20442 JJ denotes untreated
T10217 20443-20449 NN denotes joints
T10218 20449-20450 -COMMA- denotes ,
T10219 20451-20453 IN denotes in
T10220 20454-20458 CC denotes both
T10221 20459-20460 DT denotes a
T10222 20461-20473 JJ denotes prophylactic
T10223 20474-20477 CC denotes and
T10224 20478-20489 JJ denotes therapeutic
T10225 20490-20497 NN denotes setting
T10226 20499-20502 NN denotes A20
T10227 20503-20513 NN denotes expression
T10228 20514-20516 IN denotes in
T10229 20517-20525 JJ denotes synovial
T10230 20526-20532 NN denotes tissue
T10231 20533-20536 VB denotes was
T10232 20537-20547 VB denotes associated
T10233 20548-20552 IN denotes with
T10234 20553-20563 NN denotes inhibition
T10235 20564-20566 IN denotes of
T10236 20567-20572 NN denotes NF-κB
T10237 20573-20581 NN denotes activity
T10238 20582-20585 CC denotes and
T10239 20586-20595 VB denotes decreased
T10240 20596-20602 NN denotes levels
T10241 20603-20605 IN denotes of
T10242 20606-20609 NN denotes TNF
T10243 20609-20610 -COMMA- denotes ,
T10244 20611-20616 NN denotes IL-1β
T10245 20616-20617 -COMMA- denotes ,
T10246 20618-20622 NN denotes IL-6
T10247 20622-20623 -COMMA- denotes ,
T10248 20624-20631 JJ denotes soluble
T10249 20632-20637 NN denotes RANKL
T10250 20637-20638 -COMMA- denotes ,
T10251 20639-20647 NN denotes monocyte
T10252 20648-20664 JJ denotes chemo-attractant
T10253 20665-20672 NN denotes protein
T10254 20673-20674 CD denotes 1
T10255 20674-20675 -COMMA- denotes ,
T10256 20676-20679 CC denotes and
T10257 20680-20685 NN denotes IL-17
T10258 20685-20686 -COMMA- denotes ,
T10259 20687-20697 VB denotes suggesting
T10260 20698-20702 IN denotes that
T10261 20703-20706 NN denotes A20
T10262 20707-20714 VB denotes induces
T10263 20715-20716 DT denotes a
T10264 20717-20727 JJ denotes protective
T10265 20728-20734 NN denotes effect
T10266 20735-20737 IN denotes in
T10267 20738-20754 JJ denotes collagen-induced
T10268 20755-20764 NN denotes arthritis
T10269 20765-20769 NN denotes mice
T10270 20770-20777 IN denotes through
T10271 20778-20789 NN denotes suppression
T10272 20790-20792 IN denotes of
T10273 20793-20798 NN denotes NF-κB
T10274 20799-20809 NN denotes activation
T10275 20810-20813 CC denotes and
T10276 20814-20817 NF- denotes NF-
T10277 20818-20830 JJ denotes κB-dependent
T10278 20831-20835 NN denotes gene
T10279 20836-20846 NN denotes expression
T10280 20847-20848 -LRB- denotes [
T10281 20848-20850 CD denotes 51
T10282 20850-20851 -RRB- denotes ]
T10283 20853-20860 IN denotes Because
T10284 20861-20864 NN denotes TNF
T10285 20865-20868 CC denotes and
T10286 20869-20874 NN denotes IL-1β
T10287 20875-20878 VB denotes are
T10288 20879-20884 VB denotes known
T10289 20885-20887 TO denotes to
T10290 20888-20895 VB denotes mediate
T10291 20896-20905 NN denotes synovitis
T10292 20905-20906 -COMMA- denotes ,
T10293 20907-20913 NN denotes pannus
T10294 20914-20923 NN denotes formation
T10295 20923-20924 -COMMA- denotes ,
T10296 20925-20928 CC denotes and
T10297 20929-20936 NN denotes erosion
T10298 20937-20939 IN denotes of
T10299 20940-20949 NN denotes cartilage
T10300 20950-20953 CC denotes and
T10301 20954-20958 NN denotes bone
T10302 20959-20961 IN denotes in
T10303 20962-20964 NN denotes RA
T10304 20964-20965 -COMMA- denotes ,
T10305 20966-20969 DT denotes the
T10306 20970-20979 VB denotes decreased
T10307 20980-20985 NN denotes serum
T10308 20986-20992 NN denotes levels
T10309 20993-20995 IN denotes of
T10310 20996-20999 NN denotes TNF
T10311 21000-21003 CC denotes and
T10312 21004-21009 NN denotes IL-1β
T10313 21010-21012 IN denotes in
T10314 21013-21027 JJ denotes A20-transduced
T10315 21028-21032 NN denotes mice
T10316 21033-21038 MD denotes might
T10317 21039-21046 VB denotes explain
T10318 21047-21050 DT denotes the
T10319 21051-21061 JJ denotes beneficial
T10320 21062-21069 NN denotes effects
T10321 21070-21072 IN denotes in
T10322 21073-21076 DT denotes the
T10323 21077-21085 JJ denotes clinical
T10324 21085-21086 -COMMA- denotes ,
T10325 21087-21099 JJ denotes pathological
T10326 21099-21100 -COMMA- denotes ,
T10327 21101-21104 CC denotes and
T10328 21105-21117 JJ denotes radiological
T10329 21118-21126 NN denotes findings
T10330 21128-21132 DT denotes This
T10331 21133-21138 NN denotes study
T10332 21139-21143 RB denotes also
T10333 21144-21156 VB denotes demonstrated
T10334 21157-21161 IN denotes that
T10335 21162-21165 NN denotes A20
T10336 21166-21180 NN denotes overexpression
T10337 21181-21186 VB denotes leads
T10338 21187-21189 TO denotes to
T10339 21190-21191 DT denotes a
T10340 21192-21200 NN denotes decrease
T10341 21201-21203 IN denotes in
T10342 21204-21207 DT denotes the
T10343 21208-21214 NN denotes number
T10344 21215-21217 IN denotes of
T10345 21218-21227 VB denotes activated
T10346 21228-21239 NN denotes osteoclasts
T10347 21240-21242 IN denotes in
T10348 21243-21248 JJ denotes joint
T10349 21249-21255 NN denotes tissue
T10350 21257-21260 NN denotes A20
T10351 21261-21266 MD denotes might
T10352 21267-21276 RB denotes therefore
T10353 21277-21285 VB denotes minimise
T10354 21286-21291 JJ denotes joint
T10355 21292-21303 NN denotes destruction
T10356 21304-21311 IN denotes through
T10357 21312-21322 VB denotes decreasing
T10358 21323-21326 DT denotes the
T10359 21327-21337 NN denotes osteoclast
T10360 21338-21344 NN denotes number
T10361 21345-21348 CC denotes and
T10362 21349-21357 NN denotes activity
T10363 21359-21361 PRP denotes It
T10364 21362-21366 MD denotes will
T10365 21367-21369 VB denotes be
T10366 21370-21381 JJ denotes interesting
T10367 21382-21384 TO denotes to
T10368 21385-21392 VB denotes analyse
T10369 21393-21395 IN denotes in
T10370 21396-21402 JJ denotes future
T10371 21403-21406 DT denotes the
T10372 21407-21421 NN denotes susceptibility
T10373 21422-21424 IN denotes of
T10374 21425-21436 JJ denotes conditional
T10375 21437-21445 NN denotes knockout
T10376 21446-21450 NN denotes mice
T10377 21451-21455 WDT denotes that
T10378 21456-21460 VB denotes lack
T10379 21461-21464 NN denotes A20
T10380 21465-21467 IN denotes in
T10381 21468-21476 JJ denotes specific
T10382 21477-21481 NN denotes cell
T10383 21482-21487 NN denotes types
T10384 21488-21492 JJ denotes such
T10385 21493-21495 IN denotes as
T10386 21496-21504 JJ denotes synovial
T10387 21505-21516 NN denotes fibroblasts
T10388 21516-21517 -COMMA- denotes ,
T10389 21518-21529 NN denotes macrophages
T10390 21529-21530 -COMMA- denotes ,
T10391 21531-21540 JJ denotes dendritic
T10392 21541-21546 NN denotes cells
T10393 21546-21547 -COMMA- denotes ,
T10394 21548-21549 NN denotes B
T10395 21550-21555 NN denotes cells
T10396 21556-21558 CC denotes or
T10397 21559-21560 NN denotes T
T10398 21561-21566 NN denotes cells
T10399 21568-21579 RB denotes Importantly
T10400 21579-21580 -COMMA- denotes ,
T10401 21581-21588 JJ denotes several
T10402 21589-21593 NN denotes SNPs
T10403 21594-21596 IN denotes in
T10404 21597-21600 DT denotes the
T10405 21601-21606 JJ denotes human
T10406 21607-21610 NN denotes A20
T10407 21611-21616 NN denotes locus
T10408 21617-21621 VB denotes have
T10409 21622-21626 VB denotes been
T10410 21627-21637 VB denotes associated
T10411 21638-21642 IN denotes with
T10412 21643-21652 VB denotes increased
T10413 21653-21667 NN denotes susceptibility
T10414 21668-21670 TO denotes to
T10415 21671-21682 NN denotes development
T10416 21683-21685 IN denotes of
T10417 21686-21696 JJ denotes autoimmune
T10418 21697-21708 NN denotes pathologies
T10419 21709-21710 -LRB- denotes (
T10420 21710-21718 VB denotes reviewed
T10421 21719-21721 IN denotes in
T10422 21722-21723 -LRB- denotes [
T10423 21723-21725 CD denotes 52
T10424 21725-21726 -RRB- denotes ]
T10425 21726-21727 -RRB- denotes )
T10426 21729-21736 JJ denotes Several
T10427 21737-21748 JJ denotes genome-wide
T10428 21749-21760 NN denotes association
T10429 21761-21768 NN denotes studies
T10430 21769-21773 RB denotes also
T10431 21774-21782 VB denotes revealed
T10432 21783-21784 DT denotes a
T10433 21785-21790 JJ denotes clear
T10434 21791-21802 NN denotes association
T10435 21803-21810 IN denotes between
T10436 21811-21820 NN denotes mutations
T10437 21821-21823 IN denotes in
T10438 21824-21827 DT denotes the
T10439 21828-21831 NN denotes A20
T10440 21832-21837 NN denotes locus
T10441 21838-21840 IN denotes in
T10442 21841-21844 DT denotes the
T10443 21845-21849 NN denotes 6q23
T10444 21850-21860 NN denotes chromosome
T10445 21861-21864 CC denotes and
T10446 21865-21879 NN denotes susceptibility
T10447 21880-21882 TO denotes to
T10448 21883-21885 NN denotes RA
T10449 21886-21887 -LRB- denotes [
T10450 21887-21889 CD denotes 52
T10451 21889-21890 -RRB- denotes ]
T10452 21892-21900 IN denotes Although
T10453 21901-21904 DT denotes the
T10454 21905-21915 VB denotes identified
T10455 21916-21924 NN denotes variants
T10456 21925-21928 VB denotes are
T10457 21929-21932 RB denotes not
T10458 21933-21940 VB denotes located
T10459 21941-21943 IN denotes in
T10460 21944-21945 DT denotes a
T10461 21946-21950 NN denotes gene
T10462 21950-21951 -COMMA- denotes ,
T10463 21952-21956 PRP denotes they
T10464 21957-21960 VB denotes are
T10465 21961-21968 VB denotes thought
T10466 21969-21971 TO denotes to
T10467 21972-21981 VB denotes influence
T10468 21982-21985 NN denotes A20
T10469 21986-21988 IN denotes as
T10470 21989-21992 PRP-DOLLAR- denotes its
T10471 21993-22000 JJ denotes nearest
T10472 22001-22005 NN denotes gene
T10473 22006-22007 -LRB- denotes (
T10474 22007-22011 CD denotes ~150
T10475 22012-22014 NN denotes kb
T10476 22015-22025 RB denotes downstream
T10477 22026-22028 IN denotes of
T10478 22029-22032 NN denotes A20
T10479 22032-22033 -RRB- denotes )
T10480 22033-22034 -COMMA- denotes ,
T10481 22035-22043 RB denotes probably
T10482 22044-22046 IN denotes by
T10483 22047-22050 DT denotes the
T10484 22051-22059 NN denotes presence
T10485 22060-22062 IN denotes of
T10486 22063-22072 JJ denotes potential
T10487 22073-22083 JJ denotes regulatory
T10488 22084-22087 NN denotes DNA
T10489 22088-22096 NN denotes elements
T10490 22097-22099 IN denotes in
T10491 22100-22104 DT denotes this
T10492 22105-22111 NN denotes region
T10493 22113-22115 IN denotes As
T10494 22116-22119 NN denotes A20
T10495 22120-22122 VB denotes is
T10496 22123-22131 VB denotes required
T10497 22132-22135 IN denotes for
T10498 22136-22147 NN denotes termination
T10499 22148-22150 IN denotes of
T10500 22151-22162 JJ denotes TNF-induced
T10501 22163-22170 NN denotes signals
T10502 22170-22171 -COMMA- denotes ,
T10503 22172-22175 CC denotes and
T10504 22176-22179 NN denotes TNF
T10505 22180-22182 VB denotes is
T10506 22183-22186 DT denotes the
T10507 22187-22194 JJ denotes primary
T10508 22195-22207 JJ denotes inflammatory
T10509 22208-22216 NN denotes cytokine
T10510 22217-22219 IN denotes in
T10511 22220-22222 NN denotes RA
T10512 22222-22223 -COMMA- denotes ,
T10513 22224-22229 DT denotes these
T10514 22230-22238 NN denotes findings
T10515 22239-22245 VB denotes reveal
T10516 22246-22249 NN denotes A20
T10517 22250-22252 IN denotes as
T10518 22253-22254 DT denotes a
T10519 22255-22264 NN denotes candidate
T10520 22265-22279 NN denotes susceptibility
T10521 22280-22285 NN denotes locus
T10522 22286-22289 IN denotes for
T10523 22290-22292 NN denotes RA
T10524 22294-22297 WRB denotes How
T10525 22298-22303 DT denotes these
T10526 22304-22312 NN denotes variants
T10527 22313-22319 VB denotes affect
T10528 22320-22326 JJ denotes normal
T10529 22327-22330 NN denotes A20
T10530 22331-22339 NN denotes activity
T10531 22340-22343 CC denotes and
T10532 22344-22347 WRB denotes how
T10533 22348-22352 PRP denotes they
T10534 22353-22358 VB denotes cause
T10535 22359-22361 NN denotes RA
T10536 22361-22362 -COMMA- denotes ,
T10537 22363-22370 RB denotes however
T10538 22370-22371 -COMMA- denotes ,
T10539 22372-22378 VB denotes remain
T10540 22379-22386 JJ denotes unclear
T10541 22388-22396 RB denotes Recently
T10542 22396-22397 -COMMA- denotes ,
T10543 22398-22403 NNP denotes Elsby
T10544 22404-22407 CC denotes and
T10545 22408-22418 NN denotes colleagues
T10546 22419-22431 RB denotes functionally
T10547 22432-22441 VB denotes evaluated
T10548 22442-22444 FW denotes in
T10549 22445-22450 FW denotes vitro
T10550 22451-22454 DT denotes the
T10551 22455-22465 JJ denotes regulatory
T10552 22466-22473 NN denotes ability
T10553 22474-22476 IN denotes of
T10554 22477-22490 JJ denotes RA-associated
T10555 22491-22494 NN denotes SNP
T10556 22495-22503 NN denotes variants
T10557 22504-22506 IN denotes on
T10558 22507-22510 NN denotes A20
T10559 22511-22519 NN denotes promoter
T10560 22520-22528 NN denotes activity
T10561 22528-22529 -COMMA- denotes ,
T10562 22530-22533 CC denotes and
T10563 22534-22539 MD denotes could
T10564 22540-22544 VB denotes show
T10565 22545-22554 VB denotes repressed
T10566 22555-22558 NN denotes A20
T10567 22559-22572 NN denotes transcription
T10568 22573-22576 IN denotes for
T10569 22577-22581 DT denotes some
T10570 22582-22584 IN denotes of
T10571 22585-22588 DT denotes the
T10572 22589-22593 NN denotes SNPs
T10573 22594-22606 VB denotes investigated
T10574 22607-22608 -LRB- denotes [
T10575 22608-22610 CD denotes 53
T10576 22610-22611 -RRB- denotes ]
T10577 22613-22615 PRP denotes It
T10578 22616-22620 MD denotes will
T10579 22621-22623 VB denotes be
T10580 22624-22626 IN denotes of
T10581 22627-22635 NN denotes interest
T10582 22636-22638 TO denotes to
T10583 22639-22647 VB denotes identify
T10584 22648-22651 DT denotes the
T10585 22652-22658 JJ denotes actual
T10586 22659-22665 JJ denotes causal
T10587 22666-22674 NN denotes variants
T10588 22675-22678 CC denotes and
T10589 22679-22681 TO denotes to
T10590 22682-22691 VB denotes elucidate
T10591 22692-22695 DT denotes the
T10592 22696-22706 JJ denotes functional
T10593 22707-22719 NN denotes consequences
T10594 22720-22722 IN denotes of
T10595 22723-22728 DT denotes these
T10596 22729-22737 NN denotes variants
T10597 22739-22741 IN denotes In
T10598 22742-22746 DT denotes this
T10599 22747-22754 NN denotes context
T10600 22754-22755 -COMMA- denotes ,
T10601 22756-22763 JJ denotes knockin
T10602 22764-22768 NN denotes mice
T10603 22769-22772 IN denotes for
T10604 22773-22776 DT denotes the
T10605 22777-22790 VB denotes corresponding
T10606 22791-22794 NN denotes A20
T10607 22795-22799 NN denotes SNPs
T10608 22799-22800 -COMMA- denotes ,
T10609 22801-22809 VB denotes combined
T10610 22810-22814 IN denotes with
T10611 22815-22820 NN denotes mouse
T10612 22821-22827 NN denotes models
T10613 22828-22831 IN denotes for
T10614 22832-22834 NN denotes RA
T10615 22834-22835 -COMMA- denotes ,
T10616 22836-22840 MD denotes will
T10617 22841-22843 VB denotes be
T10618 22844-22848 RB denotes very
T10619 22849-22857 JJ denotes valuable
T10620 22858-22863 NN denotes tools
T12737 22866-22877 JJ denotes A20-binding
T12738 22878-22888 NN denotes inhibitors
T12739 22889-22891 IN denotes of
T12740 22892-22897 NN denotes NF-κB
T12741 22898-22904 NN denotes ABIN-1
T12742 22904-22905 -COMMA- denotes ,
T12743 22906-22912 NN denotes ABIN-2
T12744 22913-22916 CC denotes and
T12745 22917-22923 NN denotes ABIN-3
T12746 22924-22925 -LRB- denotes (
T12747 22925-22929 RB denotes also
T12748 22930-22935 VB denotes known
T12749 22936-22938 IN denotes as
T12750 22939-22945 NN denotes TNIP-1
T12751 22945-22946 -COMMA- denotes ,
T12752 22947-22953 NN denotes TNIP-2
T12753 22953-22954 -COMMA- denotes ,
T12754 22955-22958 CC denotes and
T12755 22959-22965 NN denotes TNIP-3
T12756 22965-22966 -RRB- denotes )
T12757 22967-22971 VB denotes were
T12758 22972-22982 VB denotes identified
T12759 22983-22985 IN denotes as
T12760 22986-22998 RB denotes ubiquitously
T12761 22999-23008 VB denotes expressed
T12762 23009-23012 NN denotes A20
T12763 23013-23024 VB denotes interacting
T12764 23025-23033 NN denotes proteins
T12765 23034-23037 CC denotes and
T12766 23038-23042 VB denotes were
T12767 23043-23048 VB denotes shown
T12768 23049-23051 TO denotes to
T12769 23052-23059 VB denotes inhibit
T12770 23060-23065 NN denotes NF-κB
T12771 23066-23076 NN denotes activation
T12772 23077-23079 IN denotes by
T12773 23080-23083 NN denotes TNF
T12774 23084-23087 CC denotes and
T12775 23088-23095 JJ denotes several
T12776 23096-23101 JJ denotes other
T12777 23102-23114 JJ denotes inflammatory
T12778 23115-23122 NN denotes stimuli
T12779 23123-23127 IN denotes upon
T12780 23128-23142 NN denotes overexpression
T12781 23144-23151 IN denotes Because
T12782 23152-23157 NN denotes ABINs
T12783 23158-23165 VB denotes contain
T12784 23166-23167 DT denotes a
T12785 23168-23176 JJ denotes specific
T12786 23177-23194 JJ denotes ubiquitin-binding
T12787 23195-23200 NN denotes motif
T12788 23200-23201 -COMMA- denotes ,
T12789 23202-23206 PRP denotes they
T12790 23207-23211 VB denotes have
T12791 23212-23216 VB denotes been
T12792 23217-23225 VB denotes proposed
T12793 23226-23228 TO denotes to
T12794 23229-23235 VB denotes target
T12795 23236-23239 NN denotes A20
T12796 23240-23242 TO denotes to
T12797 23243-23260 VB denotes polyubiquitinated
T12798 23261-23271 NN denotes substrates
T12799 23272-23273 -LRB- denotes [
T12800 23273-23278 CD denotes 43,44
T12801 23278-23279 -RRB- denotes ]
T12802 23281-23288 JJ denotes Similar
T12803 23289-23291 TO denotes to
T12804 23292-23295 NN denotes A20
T12805 23295-23296 -COMMA- denotes ,
T12806 23297-23303 NN denotes ABIN-1
T12807 23304-23307 CC denotes and
T12808 23308-23314 NN denotes ABIN-3
T12809 23315-23325 NN denotes expression
T12810 23326-23328 VB denotes is
T12811 23329-23334 NN denotes NF-κB
T12812 23335-23344 JJ denotes dependent
T12813 23344-23345 -COMMA- denotes ,
T12814 23346-23357 VB denotes implicating
T12815 23358-23359 DT denotes a
T12816 23360-23369 JJ denotes potential
T12817 23370-23374 NN denotes role
T12818 23375-23378 IN denotes for
T12819 23379-23382 DT denotes the
T12820 23383-23391 NN denotes A20/ABIN
T12821 23392-23399 NN denotes complex
T12822 23400-23402 IN denotes in
T12823 23403-23406 DT denotes the
T12824 23407-23415 JJ denotes negative
T12825 23416-23424 NN denotes feedback
T12826 23425-23435 NN denotes regulation
T12827 23436-23438 IN denotes of
T12828 23439-23444 NN denotes NF-κB
T12829 23445-23455 NN denotes activation
T12830 23456-23457 -LRB- denotes (
T12831 23457-23465 VB denotes reviewed
T12832 23466-23468 IN denotes in
T12833 23469-23470 -LRB- denotes [
T12834 23470-23472 CD denotes 54
T12835 23472-23473 -RRB- denotes ]
T12836 23473-23474 -RRB- denotes )
T12837 23476-23488 RB denotes Unexpectedly
T12838 23488-23489 -COMMA- denotes ,
T12839 23490-23494 CC denotes both
T12840 23495-23511 JJ denotes ABIN-1-deficient
T12841 23512-23515 CC denotes and
T12842 23516-23532 JJ denotes ABIN-2-deficient
T12843 23533-23537 NN denotes mice
T12844 23538-23545 VB denotes exhibit
T12845 23546-23550 RB denotes only
T12846 23551-23559 RB denotes slightly
T12847 23560-23569 VB denotes increased
T12848 23570-23572 CC denotes or
T12849 23573-23579 JJ denotes normal
T12850 23580-23585 NN denotes NF-κB
T12851 23586-23595 NN denotes responses
T12852 23595-23596 -COMMA- denotes ,
T12853 23597-23609 RB denotes respectively
T12854 23609-23610 -COMMA- denotes ,
T12855 23611-23619 RB denotes possibly
T12856 23620-23630 VB denotes reflecting
T12857 23631-23640 JJ denotes redundant
T12858 23641-23646 NN denotes NF-κB
T12859 23647-23657 JJ denotes inhibitory
T12860 23658-23668 NN denotes activities
T12861 23669-23671 IN denotes of
T12862 23672-23680 JJ denotes multiple
T12863 23681-23686 NN denotes ABINs
T12864 23687-23688 -LRB- denotes [
T12865 23688-23693 CD denotes 55,56
T12866 23693-23694 -RRB- denotes ]
T12867 23696-23706 JJ denotes Functional
T12868 23707-23713 NN denotes ABIN-3
T12869 23714-23716 VB denotes is
T12870 23717-23726 VB denotes expressed
T12871 23727-23729 IN denotes in
T12872 23730-23736 NN denotes humans
T12873 23736-23737 -COMMA- denotes ,
T12874 23738-23741 CC denotes but
T12875 23742-23746 NN denotes mice
T12876 23747-23751 RB denotes only
T12877 23752-23759 VB denotes express
T12878 23760-23761 DT denotes a
T12879 23762-23771 VB denotes truncated
T12880 23772-23775 CC denotes and
T12881 23776-23784 JJ denotes inactive
T12882 23785-23789 NN denotes form
T12883 23790-23797 VB denotes lacking
T12884 23798-23801 DT denotes the
T12885 23802-23809 JJ denotes crucial
T12886 23810-23827 JJ denotes ubiquitin-binding
T12887 23828-23834 NN denotes domain
T12888 23835-23836 -LRB- denotes [
T12889 23836-23838 CD denotes 57
T12890 23838-23839 -RRB- denotes ]
T12891 23841-23843 IN denotes As
T12892 23844-23847 IN denotes for
T12893 23848-23851 NN denotes A20
T12894 23851-23852 -COMMA- denotes ,
T12895 23853-23859 NN denotes ABIN-1
T12896 23860-23864 RB denotes also
T12897 23865-23873 RB denotes strongly
T12898 23874-23882 VB denotes inhibits
T12899 23883-23894 JJ denotes TNF-induced
T12900 23895-23904 NN denotes apoptosis
T12901 23905-23906 -LRB- denotes [
T12902 23906-23908 CD denotes 58
T12903 23908-23909 -RRB- denotes ]
T12904 23909-23910 -COMMA- denotes ,
T12905 23911-23914 CC denotes and
T12906 23915-23921 NN denotes ABIN-1
T12907 23922-23931 JJ denotes deficient
T12908 23932-23936 NN denotes mice
T12909 23937-23940 VB denotes die
T12910 23941-23954 RB denotes embryonically
T12911 23955-23958 JJ denotes due
T12912 23959-23961 TO denotes to
T12913 23962-23975 JJ denotes TNF-dependent
T12914 23976-23982 JJ denotes foetal
T12915 23983-23988 NN denotes liver
T12916 23989-23998 NN denotes apoptosis
T12917 23999-24000 -LRB- denotes [
T12918 24000-24002 CD denotes 56
T12919 24002-24003 -RRB- denotes ]
T12920 24005-24010 VB denotes Using
T12921 24011-24026 NN denotes oligonucleotide
T12922 24027-24037 NN denotes microarray
T12923 24038-24046 NN denotes analysis
T12924 24046-24047 -COMMA- denotes ,
T12925 24048-24054 NN denotes ABIN-1
T12926 24055-24058 VB denotes was
T12927 24059-24069 VB denotes identified
T12928 24070-24075 IN denotes among
T12929 24076-24087 JJ denotes TNF-induced
T12930 24088-24093 NN denotes genes
T12931 24094-24096 IN denotes in
T12932 24097-24102 JJ denotes human
T12933 24103-24115 NN denotes synoviocytes
T12934 24115-24116 -COMMA- denotes ,
T12935 24117-24120 CC denotes and
T12936 24121-24125 JJ denotes high
T12937 24126-24132 NN denotes levels
T12938 24133-24135 IN denotes of
T12939 24136-24142 NN denotes ABIN-1
T12940 24143-24147 NN denotes mRNA
T12941 24148-24152 VB denotes were
T12942 24153-24161 VB denotes detected
T12943 24162-24164 IN denotes in
T12944 24165-24167 NN denotes RA
T12945 24168-24174 NN denotes tissue
T12946 24175-24183 NN denotes biopsies
T12947 24183-24184 -COMMA- denotes ,
T12948 24185-24195 VB denotes indicating
T12949 24196-24197 DT denotes a
T12950 24198-24207 JJ denotes potential
T12951 24208-24212 NN denotes role
T12952 24213-24216 IN denotes for
T12953 24217-24223 NN denotes ABIN-1
T12954 24223-24224 -COMMA- denotes ,
T12955 24225-24233 RB denotes together
T12956 24234-24238 IN denotes with
T12957 24239-24242 NN denotes A20
T12958 24242-24243 -COMMA- denotes ,
T12959 24244-24246 IN denotes in
T12960 24247-24250 DT denotes the
T12961 24251-24259 JJ denotes negative
T12962 24260-24268 NN denotes feedback
T12963 24269-24279 NN denotes regulation
T12964 24280-24282 IN denotes of
T12965 24283-24288 NN denotes NF-κB
T12966 24289-24299 NN denotes signalling
T12967 24300-24303 CC denotes and
T12968 24304-24307 DT denotes the
T12969 24308-24320 NN denotes pathogenesis
T12970 24321-24323 IN denotes of
T12971 24324-24326 NN denotes RA
T12972 24327-24328 -LRB- denotes [
T12973 24328-24330 CD denotes 59
T12974 24330-24331 -RRB- denotes ]
T12975 24333-24335 IN denotes In
T12976 24336-24337 DT denotes a
T12977 24338-24344 JJ denotes recent
T12978 24345-24350 NN denotes study
T12979 24350-24351 -COMMA- denotes ,
T12980 24352-24362 NN denotes inhibition
T12981 24363-24365 IN denotes of
T12982 24366-24369 NN denotes TLR
T12983 24370-24379 NN denotes responses
T12984 24380-24382 IN denotes by
T12985 24383-24397 NN denotes immunoreceptor
T12986 24398-24412 JJ denotes tyrosine-based
T12987 24413-24423 NN denotes activation
T12988 24424-24429 NN denotes motif
T12989 24430-24431 -LRB- denotes (
T12990 24431-24435 NN denotes ITAM
T12991 24435-24436 -RRB- denotes )
T12992 24436-24444 JJ denotes -coupled
T12993 24445-24454 NN denotes receptors
T12994 24455-24458 VB denotes was
T12995 24459-24464 VB denotes shown
T12996 24465-24467 TO denotes to
T12997 24468-24474 VB denotes depend
T12998 24475-24477 IN denotes on
T12999 24478-24481 DT denotes the
T13000 24482-24492 NN denotes expression
T13001 24493-24495 IN denotes of
T13002 24496-24499 DT denotes the
T13003 24500-24505 NN denotes NF-κB
T13004 24506-24516 JJ denotes inhibitory
T13005 24517-24525 NN denotes proteins
T13006 24526-24532 NN denotes ABIN-3
T13007 24533-24536 CC denotes and
T13008 24537-24540 NN denotes A20
T13009 24542-24550 RB denotes Moreover
T13010 24550-24551 -COMMA- denotes ,
T13011 24552-24556 DT denotes this
T13012 24557-24567 JJ denotes protective
T13013 24568-24574 NN denotes effect
T13014 24575-24577 IN denotes of
T13015 24578-24581 DT denotes the
T13016 24582-24586 NNP denotes ITAM
T13017 24587-24590 VB denotes was
T13018 24591-24599 RB denotes strongly
T13019 24600-24610 VB denotes suppressed
T13020 24611-24613 IN denotes in
T13021 24614-24626 JJ denotes inflammatory
T13022 24627-24636 NN denotes arthritis
T13023 24637-24645 JJ denotes synovial
T13024 24646-24657 NN denotes macrophages
T13025 24658-24659 -LRB- denotes [
T13026 24659-24661 CD denotes 60
T13027 24661-24662 -RRB- denotes ]
T13028 24664-24677 RB denotes Interestingly
T13029 24677-24678 -COMMA- denotes ,
T13030 24679-24685 NN denotes ABIN-1
T13031 24686-24699 NN denotes polymorphisms
T13032 24700-24704 VB denotes have
T13033 24705-24709 VB denotes been
T13034 24710-24720 VB denotes associated
T13035 24721-24725 IN denotes with
T13036 24726-24735 NN denotes psoriasis
T13037 24736-24739 CC denotes and
T13038 24740-24748 JJ denotes systemic
T13039 24749-24754 NN denotes lupus
T13040 24755-24768 NN denotes erythematosus
T13041 24769-24771 IN denotes in
T13042 24772-24778 NN denotes humans
T13043 24779-24780 -LRB- denotes [
T13044 24780-24785 CD denotes 61,62
T13045 24785-24786 -RRB- denotes ]
T13046 24788-24789 DT denotes A
T13047 24790-24794 JJ denotes high
T13048 24795-24801 NN denotes degree
T13049 24802-24804 IN denotes of
T13050 24805-24812 NN denotes overlap
T13051 24813-24820 IN denotes between
T13052 24821-24829 JJ denotes systemic
T13053 24830-24835 NN denotes lupus
T13054 24836-24849 NN denotes erythematosus
T13055 24850-24853 CC denotes and
T13056 24854-24856 NN denotes RA
T13057 24857-24871 NN denotes susceptibility
T13058 24872-24876 NN denotes loci
T13059 24877-24882 MD denotes might
T13060 24883-24885 VB denotes be
T13061 24886-24894 VB denotes expected
T13062 24895-24897 IN denotes as
T13063 24898-24901 DT denotes the
T13064 24902-24905 CD denotes two
T13065 24906-24914 NN denotes diseases
T13066 24915-24919 VB denotes show
T13067 24920-24924 DT denotes some
T13068 24925-24933 JJ denotes clinical
T13069 24934-24941 NN denotes overlap
T13070 24942-24944 IN denotes in
T13071 24945-24950 JJ denotes joint
T13072 24951-24962 NN denotes involvement
T13073 24962-24963 -COMMA- denotes ,
T13074 24964-24976 NN denotes autoantibody
T13075 24977-24987 NN denotes production
T13076 24987-24988 -COMMA- denotes ,
T13077 24989-24997 JJ denotes systemic
T13078 24998-25006 NN denotes features
T13079 25007-25010 CC denotes and
T13080 25011-25019 NN denotes response
T13081 25020-25022 TO denotes to
T13082 25023-25033 NN denotes treatments
T13083 25034-25038 JJ denotes such
T13084 25039-25041 IN denotes as
T13085 25042-25048 NN denotes B-cell
T13086 25049-25058 NN denotes depletion
T13087 25059-25060 -LRB- denotes (
T13088 25060-25069 NN denotes rituximab
T13089 25069-25070 -RRB- denotes )
T13090 25072-25074 PRP denotes It
T13091 25075-25079 MD denotes will
T13092 25080-25089 RB denotes therefore
T13093 25090-25092 VB denotes be
T13094 25093-25104 JJ denotes interesting
T13095 25105-25107 TO denotes to
T13096 25108-25119 VB denotes investigate
T13097 25120-25127 IN denotes whether
T13098 25128-25132 NN denotes SNPs
T13099 25133-25137 WDT denotes that
T13100 25138-25142 VB denotes have
T13101 25143-25147 VB denotes been
T13102 25148-25156 VB denotes reported
T13103 25157-25159 TO denotes to
T13104 25160-25162 VB denotes be
T13105 25163-25173 VB denotes associated
T13106 25174-25178 IN denotes with
T13107 25179-25187 JJ denotes systemic
T13108 25188-25193 NN denotes lupus
T13109 25194-25207 NN denotes erythematosus
T13110 25208-25211 VB denotes are
T13111 25212-25216 RB denotes also
T13112 25217-25227 VB denotes associated
T13113 25228-25232 IN denotes with
T13114 25233-25235 NN denotes RA
T14244 25238-25253 NN denotes Cylindromatosis
T14245 25254-25261 NN denotes protein
T14246 25262-25277 NN denotes Cylindromatosis
T14247 25278-25279 -LRB- denotes (
T14248 25279-25283 NN denotes CYLD
T14249 25283-25284 -RRB- denotes )
T14250 25285-25292 NN denotes protein
T14251 25293-25296 VB denotes was
T14252 25297-25307 RB denotes originally
T14253 25308-25318 VB denotes identified
T14254 25319-25321 IN denotes as
T14255 25322-25323 DT denotes a
T14256 25324-25330 NN denotes tumour
T14257 25331-25341 NN denotes suppressor
T14258 25342-25350 VB denotes involved
T14259 25351-25353 IN denotes in
T14260 25354-25362 JJ denotes familial
T14261 25363-25378 NN denotes cylindromatosis
T14262 25379-25380 -LRB- denotes [
T14263 25380-25382 CD denotes 63
T14264 25382-25383 -RRB- denotes ]
T14265 25385-25389 NN denotes CYLD
T14266 25390-25392 VB denotes is
T14267 25393-25397 RB denotes also
T14268 25398-25406 VB denotes involved
T14269 25406-25407 -COMMA- denotes ,
T14270 25408-25415 RB denotes however
T14271 25415-25416 -COMMA- denotes ,
T14272 25417-25419 IN denotes in
T14273 25420-25427 JJ denotes diverse
T14274 25428-25441 JJ denotes physiological
T14275 25442-25451 NN denotes processes
T14276 25452-25459 VB denotes ranging
T14277 25460-25464 IN denotes from
T14278 25465-25473 NN denotes immunity
T14279 25474-25477 CC denotes and
T14280 25478-25490 NN denotes inflammation
T14281 25491-25493 TO denotes to
T14282 25494-25498 NN denotes cell
T14283 25499-25504 NN denotes cycle
T14284 25505-25516 NN denotes progression
T14285 25516-25517 -COMMA- denotes ,
T14286 25518-25533 NN denotes spermatogenesis
T14287 25533-25534 -COMMA- denotes ,
T14288 25535-25538 CC denotes and
T14289 25539-25557 NN denotes osteoclastogenesis
T14290 25558-25559 -LRB- denotes (
T14291 25559-25567 VB denotes reviewed
T14292 25568-25570 IN denotes in
T14293 25571-25572 -LRB- denotes [
T14294 25572-25574 CD denotes 64
T14295 25574-25575 -RRB- denotes ]
T14296 25575-25576 -RRB- denotes )
T14297 25578-25582 NN denotes CYLD
T14298 25583-25585 VB denotes is
T14299 25586-25587 DT denotes a
T14300 25588-25604 VB denotes deubiquitinating
T14301 25605-25611 NN denotes enzyme
T14302 25612-25616 WDT denotes that
T14303 25617-25627 RB denotes negatively
T14304 25628-25637 VB denotes regulates
T14305 25638-25643 NN denotes NF-κB
T14306 25644-25654 NN denotes signalling
T14307 25655-25664 VB denotes initiated
T14308 25665-25667 IN denotes by
T14309 25668-25672 NN denotes TNFR
T14310 25672-25673 -COMMA- denotes ,
T14311 25674-25678 NN denotes RANK
T14312 25679-25682 CC denotes and
T14313 25683-25689 NN denotes T-cell
T14314 25690-25698 NN denotes receptor
T14315 25699-25710 NN denotes stimulation
T14316 25711-25712 -LRB- denotes (
T14317 25712-25720 VB denotes reviewed
T14318 25721-25723 IN denotes in
T14319 25724-25725 -LRB- denotes [
T14320 25725-25727 CD denotes 64
T14321 25727-25728 -RRB- denotes ]
T14322 25728-25729 -RRB- denotes )
T14323 25730-25731 -LRB- denotes (
T14324 25731-25737 NN denotes Figure
T14325 25738-25739 CD denotes 1
T14326 25739-25740 -RRB- denotes )
T14327 25740-25741 -COMMA- denotes ,
T14328 25742-25744 IN denotes by
T14329 25745-25762 JJ denotes deubiquitina-ting
T14330 25763-25770 JJ denotes several
T14331 25771-25776 NN denotes NF-κB
T14332 25777-25787 NN denotes signalling
T14333 25788-25796 NN denotes proteins
T14334 25797-25806 VB denotes including
T14335 25807-25811 NN denotes NEMO
T14336 25811-25812 -COMMA- denotes ,
T14337 25813-25818 NN denotes TRAF2
T14338 25818-25819 -COMMA- denotes ,
T14339 25820-25825 NN denotes TRAF6
T14340 25825-25826 -COMMA- denotes ,
T14341 25827-25832 NN denotes TRAF7
T14342 25832-25833 -COMMA- denotes ,
T14343 25834-25838 NN denotes RIP1
T14344 25839-25842 CC denotes and
T14345 25843-25847 NN denotes TAK1
T14346 25849-25853 JJ denotes Many
T14347 25854-25856 IN denotes of
T14348 25857-25862 DT denotes these
T14349 25863-25866 VB denotes are
T14350 25867-25871 RB denotes also
T14351 25872-25880 VB denotes targeted
T14352 25881-25883 IN denotes by
T14353 25884-25887 NN denotes A20
T14354 25888-25891 CC denotes and
T14355 25892-25894 PRP denotes it
T14356 25895-25897 VB denotes is
T14357 25898-25903 RB denotes still
T14358 25904-25907 RB denotes not
T14359 25908-25913 JJ denotes clear
T14360 25914-25917 WRB denotes why
T14361 25918-25921 DT denotes the
T14362 25922-25926 NN denotes cell
T14363 25927-25932 VB denotes needs
T14364 25933-25936 NN denotes A20
T14365 25937-25939 RB denotes as
T14366 25940-25944 RB denotes well
T14367 25945-25947 IN denotes as
T14368 25948-25952 NN denotes CYLD
T14369 25953-25955 TO denotes to
T14370 25956-25963 VB denotes control
T14371 25964-25969 NN denotes NF-κB
T14372 25970-25980 NN denotes activation
T14373 25982-25984 IN denotes As
T14374 25985-25988 NN denotes A20
T14375 25989-25991 VB denotes is
T14376 25992-25996 RB denotes only
T14377 25997-26006 VB denotes expressed
T14378 26007-26009 IN denotes in
T14379 26010-26014 JJ denotes many
T14380 26015-26019 NN denotes cell
T14381 26020-26025 NN denotes types
T14382 26026-26030 IN denotes upon
T14383 26031-26042 NN denotes stimulation
T14384 26042-26043 -COMMA- denotes ,
T14385 26044-26046 PRP denotes it
T14386 26047-26050 VB denotes has
T14387 26051-26055 VB denotes been
T14388 26056-26065 VB denotes suggested
T14389 26066-26070 IN denotes that
T14390 26071-26075 DT denotes this
T14391 26076-26083 NN denotes protein
T14392 26084-26090 RB denotes mainly
T14393 26091-26100 VB denotes regulates
T14394 26101-26106 JJ denotes later
T14395 26107-26113 NN denotes phases
T14396 26114-26116 IN denotes of
T14397 26117-26122 NN denotes NF-κB
T14398 26123-26133 NN denotes signalling
T14399 26133-26134 -COMMA- denotes ,
T14400 26135-26142 IN denotes whereas
T14401 26143-26147 NN denotes CYLD
T14402 26148-26153 MD denotes would
T14403 26154-26162 VB denotes regulate
T14404 26163-26175 JJ denotes constitutive
T14405 26176-26179 CC denotes and
T14406 26180-26185 JJ denotes early
T14407 26186-26196 NN denotes signalling
T14408 26198-26200 IN denotes In
T14409 26201-26209 NN denotes addition
T14410 26209-26210 -COMMA- denotes ,
T14411 26211-26216 PRP-DOLLAR- denotes their
T14412 26217-26225 JJ denotes relative
T14413 26226-26234 NN denotes activity
T14414 26235-26240 MD denotes might
T14415 26241-26245 RB denotes also
T14416 26246-26248 VB denotes be
T14417 26249-26258 JJ denotes cell-type
T14418 26259-26268 JJ denotes dependent
T14419 26269-26270 -LRB- denotes [
T14420 26270-26272 CD denotes 64
T14421 26272-26273 -RRB- denotes ]
T14422 26275-26288 RB denotes Interestingly
T14423 26288-26289 -COMMA- denotes ,
T14424 26290-26294 NN denotes CYLD
T14425 26295-26298 VB denotes has
T14426 26299-26303 VB denotes been
T14427 26304-26309 VB denotes shown
T14428 26310-26312 TO denotes to
T14429 26313-26323 RB denotes negatively
T14430 26324-26332 VB denotes regulate
T14431 26333-26337 NN denotes RANK
T14432 26338-26348 NN denotes signalling
T14433 26349-26352 CC denotes and
T14434 26353-26371 NN denotes osteoclastogenesis
T14435 26372-26374 IN denotes in
T14436 26375-26379 NN denotes mice
T14437 26380-26381 -LRB- denotes [
T14438 26381-26383 CD denotes 65
T14439 26383-26384 -RRB- denotes ]
T14440 26386-26390 NN denotes Mice
T14441 26391-26395 IN denotes with
T14442 26396-26397 DT denotes a
T14443 26398-26405 JJ denotes genetic
T14444 26406-26416 NN denotes deficiency
T14445 26417-26419 IN denotes of
T14446 26420-26424 NN denotes CYLD
T14447 26425-26429 VB denotes have
T14448 26430-26438 JJ denotes aberrant
T14449 26439-26449 NN denotes osteoclast
T14450 26450-26465 NN denotes differentiation
T14451 26466-26469 CC denotes and
T14452 26470-26477 VB denotes develop
T14453 26478-26484 JJ denotes severe
T14454 26485-26497 NN denotes osteoporosis
T14455 26499-26509 NN denotes Osteoclast
T14456 26510-26520 NN denotes precursors
T14457 26521-26523 IN denotes of
T14458 26524-26529 DT denotes these
T14459 26530-26534 NN denotes mice
T14460 26535-26538 VB denotes are
T14461 26539-26555 JJ denotes hyper-responsive
T14462 26556-26558 TO denotes to
T14463 26559-26572 JJ denotes RANKL-induced
T14464 26573-26588 NN denotes differentiation
T14465 26589-26592 CC denotes and
T14466 26593-26600 VB denotes produce
T14467 26601-26605 JJ denotes more
T14468 26606-26609 CC denotes and
T14469 26610-26616 JJ denotes larger
T14470 26617-26628 NN denotes osteoclasts
T14471 26630-26634 NN denotes CYLD
T14472 26635-26645 NN denotes expression
T14473 26646-26648 VB denotes is
T14474 26649-26657 RB denotes markedly
T14475 26658-26669 VB denotes upregulated
T14476 26670-26675 IN denotes under
T14477 26676-26686 NN denotes conditions
T14478 26687-26689 IN denotes of
T14479 26690-26703 JJ denotes RANKL-induced
T14480 26704-26722 NN denotes osteoclastogenesis
T14481 26723-26726 CC denotes and
T14482 26727-26729 VB denotes is
T14483 26730-26739 VB denotes recruited
T14484 26740-26742 TO denotes to
T14485 26743-26756 VB denotes ubiquitinated
T14486 26757-26762 NN denotes TRAF6
T14487 26763-26766 IN denotes via
T14488 26767-26770 DT denotes the
T14489 26771-26788 JJ denotes ubiquitin-binding
T14490 26789-26796 NN denotes adaptor
T14491 26797-26804 NN denotes protein
T14492 26805-26808 NN denotes p62
T14493 26809-26810 -LRB- denotes (
T14494 26810-26814 RB denotes also
T14495 26815-26820 VB denotes known
T14496 26821-26823 IN denotes as
T14497 26824-26836 NN denotes sequestosome
T14498 26837-26838 CD denotes 1
T14499 26838-26839 -RRB- denotes )
T14500 26840-26841 -LRB- denotes [
T14501 26841-26843 CD denotes 65
T14502 26843-26844 -RRB- denotes ]
T14503 26844-26845 -COMMA- denotes ,
T14504 26846-26854 VB denotes followed
T14505 26855-26857 IN denotes by
T14506 26858-26861 DT denotes the
T14507 26862-26875 JJ denotes CYLD-mediated
T14508 26876-26892 NN denotes deubiquitination
T14509 26893-26895 IN denotes of
T14510 26896-26901 NN denotes TRAF6
T14511 26903-26905 IN denotes In
T14512 26906-26910 DT denotes this
T14513 26911-26918 NN denotes context
T14514 26918-26919 -COMMA- denotes ,
T14515 26920-26922 PRP denotes it
T14516 26923-26925 VB denotes is
T14517 26926-26931 JJ denotes worth
T14518 26932-26942 VB denotes mentioning
T14519 26943-26947 IN denotes that
T14520 26948-26958 JJ denotes transgenic
T14521 26959-26963 NN denotes mice
T14522 26964-26974 VB denotes expressing
T14523 26975-26976 DT denotes a
T14524 26977-26984 VB denotes mutated
T14525 26985-26989 NN denotes form
T14526 26990-26992 IN denotes of
T14527 26993-26996 NN denotes p62
T14528 26997-27001 RB denotes also
T14529 27002-27009 VB denotes display
T14530 27010-27018 JJ denotes abnormal
T14531 27019-27037 NN denotes osteoclastogenesis
T14532 27038-27041 CC denotes and
T14533 27042-27049 VB denotes develop
T14534 27050-27061 JJ denotes progressive
T14535 27062-27066 NN denotes bone
T14536 27067-27071 NN denotes loss
T14537 27072-27073 -LRB- denotes [
T14538 27073-27075 CD denotes 66
T14539 27075-27076 -RRB- denotes ]
T14540 27078-27083 DT denotes These
T14541 27084-27092 NN denotes findings
T14542 27093-27100 VB denotes suggest
T14543 27101-27105 IN denotes that
T14544 27106-27119 JJ denotes CYLD-mediated
T14545 27120-27131 NN denotes inhibi-tion
T14546 27132-27134 IN denotes of
T14547 27135-27147 JJ denotes RANK-induced
T14548 27148-27153 NN denotes NF-κB
T14549 27154-27164 NN denotes signalling
T14550 27165-27170 VB denotes plays
T14551 27171-27172 DT denotes a
T14552 27173-27176 JJ denotes key
T14553 27177-27181 NN denotes role
T14554 27182-27184 IN denotes in
T14555 27185-27188 DT denotes the
T14556 27189-27197 JJ denotes negative
T14557 27198-27208 NN denotes regulation
T14558 27209-27211 IN denotes of
T14559 27212-27230 NN denotes osteoclastogenesis
T14560 27231-27234 CC denotes and
T14561 27235-27243 VB denotes indicate
T14562 27244-27248 NN denotes CYLD
T14563 27249-27251 IN denotes as
T14564 27252-27253 DT denotes a
T14565 27254-27263 JJ denotes potential
T14566 27264-27271 JJ denotes genetic
T14567 27272-27278 NN denotes factor
T14568 27279-27287 VB denotes involved
T14569 27288-27290 IN denotes in
T14570 27291-27294 DT denotes the
T14571 27295-27304 NN denotes pathology
T14572 27305-27307 IN denotes of
T14573 27308-27312 NN denotes bone
T14574 27313-27322 NN denotes disorders
T14575 27323-27327 JJ denotes such
T14576 27328-27330 IN denotes as
T14577 27331-27333 NN denotes RA
T15547 27336-27357 JJ denotes Single-immunoglobulin
T15548 27358-27362 NN denotes IL-1
T15549 27363-27379 JJ denotes receptor-related
T15550 27380-27387 NN denotes protein
T15551 27388-27409 JJ denotes Single-immunoglobulin
T15552 27410-27414 NN denotes IL-1
T15553 27415-27431 JJ denotes receptor-related
T15554 27432-27433 -LRB- denotes (
T15555 27433-27439 NN denotes SIGIRR
T15556 27439-27440 -RRB- denotes )
T15557 27441-27448 NN denotes protein
T15558 27448-27449 -COMMA- denotes ,
T15559 27450-27454 RB denotes also
T15560 27455-27460 VB denotes known
T15561 27461-27463 IN denotes as
T15562 27464-27469 NN denotes TIR-8
T15563 27469-27470 -COMMA- denotes ,
T15564 27471-27473 VB denotes is
T15565 27474-27475 DT denotes a
T15566 27476-27482 NN denotes member
T15567 27483-27485 IN denotes of
T15568 27486-27489 DT denotes the
T15569 27490-27499 NN denotes TLR/IL-1R
T15570 27500-27506 NN denotes family
T15571 27507-27511 WDT denotes that
T15572 27512-27515 VB denotes has
T15573 27516-27520 VB denotes been
T15574 27521-27532 RB denotes extensively
T15575 27533-27546 VB denotes characterised
T15576 27547-27549 IN denotes as
T15577 27550-27552 DT denotes an
T15578 27553-27562 NN denotes inhibitor
T15579 27563-27565 IN denotes of
T15580 27566-27571 NN denotes IL-1R
T15581 27572-27575 CC denotes and
T15582 27576-27579 NN denotes TLR
T15583 27580-27590 NN denotes signalling
T15584 27590-27591 -COMMA- denotes ,
T15585 27592-27600 RB denotes probably
T15586 27601-27608 IN denotes through
T15587 27609-27615 JJ denotes direct
T15588 27616-27627 NN denotes interaction
T15589 27628-27632 IN denotes with
T15590 27633-27638 DT denotes these
T15591 27639-27648 NN denotes receptors
T15592 27648-27649 -COMMA- denotes ,
T15593 27650-27655 NN denotes MyD88
T15594 27655-27656 -COMMA- denotes ,
T15595 27657-27662 NN denotes IRAK1
T15596 27663-27665 CC denotes or
T15597 27666-27671 NN denotes TRAF6
T15598 27672-27673 -LRB- denotes [
T15599 27673-27675 CD denotes 67
T15600 27675-27676 -RRB- denotes ]
T15601 27677-27678 -LRB- denotes (
T15602 27678-27684 NN denotes Figure
T15603 27685-27686 CD denotes 1
T15604 27686-27687 -RRB- denotes )
T15605 27689-27694 VB denotes Given
T15606 27695-27698 DT denotes the
T15607 27699-27708 JJ denotes important
T15608 27709-27713 NN denotes role
T15609 27714-27716 IN denotes of
T15610 27717-27722 NN denotes IL-1R
T15611 27723-27726 CC denotes and
T15612 27727-27730 NN denotes TLR
T15613 27731-27741 NN denotes signalling
T15614 27742-27744 IN denotes in
T15615 27745-27748 DT denotes the
T15616 27749-27756 JJ denotes chronic
T15617 27757-27769 NN denotes inflammation
T15618 27770-27778 VB denotes observed
T15619 27779-27781 IN denotes in
T15620 27782-27784 NN denotes RA
T15621 27785-27786 -LRB- denotes [
T15622 27786-27788 CD denotes 68
T15623 27788-27789 -RRB- denotes ]
T15624 27789-27790 -COMMA- denotes ,
T15625 27791-27792 DT denotes a
T15626 27793-27803 JJ denotes regulatory
T15627 27804-27808 NN denotes role
T15628 27809-27812 IN denotes for
T15629 27813-27819 NN denotes SIGIRR
T15630 27820-27822 IN denotes in
T15631 27823-27825 NN denotes RA
T15632 27826-27828 VB denotes is
T15633 27829-27832 RB denotes not
T15634 27833-27841 JJ denotes unlikely
T15635 27843-27849 NN denotes SIGIRR
T15636 27850-27853 VB denotes has
T15637 27854-27855 DT denotes a
T15638 27856-27860 RB denotes very
T15639 27861-27871 JJ denotes restricted
T15640 27872-27882 NN denotes expression
T15641 27883-27890 NN denotes pattern
T15642 27890-27891 -COMMA- denotes ,
T15643 27892-27897 VB denotes being
T15644 27898-27907 VB denotes expressed
T15645 27908-27910 IN denotes in
T15646 27911-27921 JJ denotes epithelial
T15647 27922-27927 NN denotes cells
T15648 27927-27928 -COMMA- denotes ,
T15649 27929-27938 NN denotes monocytes
T15650 27939-27942 CC denotes and
T15651 27943-27951 JJ denotes immature
T15652 27952-27961 JJ denotes dendritic
T15653 27962-27967 NN denotes cells
T15654 27967-27968 -COMMA- denotes ,
T15655 27969-27972 CC denotes but
T15656 27973-27976 RB denotes not
T15657 27977-27979 IN denotes in
T15658 27980-27986 JJ denotes mature
T15659 27987-27999 NN denotes macro-phages
T15660 28000-28001 -LRB- denotes [
T15661 28001-28006 CD denotes 69,70
T15662 28006-28007 -RRB- denotes ]
T15663 28009-28017 RB denotes Recently
T15664 28017-28018 -COMMA- denotes ,
T15665 28019-28025 NN denotes SIGIRR
T15666 28026-28040 NN denotes overexpression
T15667 28041-28044 VB denotes was
T15668 28045-28050 VB denotes shown
T15669 28051-28053 TO denotes to
T15670 28054-28061 VB denotes inhibit
T15671 28062-28065 DT denotes the
T15672 28066-28077 JJ denotes spontaneous
T15673 28078-28085 NN denotes release
T15674 28086-28088 IN denotes of
T15675 28089-28101 JJ denotes inflammatory
T15676 28102-28111 NN denotes cytokines
T15677 28112-28114 IN denotes by
T15678 28115-28120 JJ denotes human
T15679 28121-28123 NN denotes RA
T15680 28124-28132 JJ denotes synovial
T15681 28133-28138 NN denotes cells
T15682 28140-28144 DT denotes This
T15683 28145-28155 JJ denotes inhibitory
T15684 28156-28164 NN denotes function
T15685 28165-28167 IN denotes of
T15686 28168-28174 NN denotes SIGIRR
T15687 28175-28178 VB denotes was
T15688 28179-28186 RB denotes further
T15689 28187-28196 VB denotes confirmed
T15690 28197-28199 FW denotes in
T15691 28200-28204 FW denotes vivo
T15692 28204-28205 -COMMA- denotes ,
T15693 28206-28211 IN denotes since
T15694 28212-28228 JJ denotes SIGIRR-deficient
T15695 28229-28233 NN denotes mice
T15696 28234-28243 VB denotes developed
T15697 28244-28245 DT denotes a
T15698 28246-28250 RB denotes more
T15699 28251-28257 JJ denotes severe
T15700 28258-28265 NN denotes disease
T15701 28266-28268 IN denotes in
T15702 28269-28284 JJ denotes zymosan-induced
T15703 28285-28294 NN denotes arthritis
T15704 28294-28295 -COMMA- denotes ,
T15705 28296-28298 RB denotes as
T15706 28299-28303 RB denotes well
T15707 28304-28306 IN denotes as
T15708 28307-28323 JJ denotes collagen-induced
T15709 28324-28333 NN denotes arthritis
T15710 28334-28339 NN denotes mouse
T15711 28340-28346 NN denotes models
T15712 28347-28348 -LRB- denotes [
T15713 28348-28350 CD denotes 70
T15714 28350-28351 -RRB- denotes ]
T15715 28353-28355 PRP denotes It
T15716 28356-28360 MD denotes will
T15717 28361-28363 VB denotes be
T15718 28364-28375 JJ denotes interesting
T15719 28376-28378 TO denotes to
T15720 28379-28386 VB denotes compare
T15721 28387-28390 DT denotes the
T15722 28391-28401 NN denotes expression
T15723 28402-28404 IN denotes of
T15724 28405-28411 NN denotes SIGIRR
T15725 28412-28414 IN denotes in
T15726 28415-28417 NN denotes RA
T15727 28418-28426 NN denotes patients
T15728 28427-28431 IN denotes with
T15729 28432-28435 PRP-DOLLAR- denotes its
T15730 28436-28446 NN denotes expression
T15731 28447-28449 IN denotes in
T15732 28450-28457 NN denotes control
T15733 28458-28466 NN denotes patients
T15734 28466-28467 -COMMA- denotes ,
T15735 28468-28470 CC denotes or
T15736 28471-28473 TO denotes to
T15737 28474-28485 VB denotes investigate
T15738 28486-28493 IN denotes whether
T15739 28494-28497 DT denotes the
T15740 28498-28506 NN denotes function
T15741 28507-28509 IN denotes of
T15742 28510-28516 NN denotes SIGIRR
T15743 28517-28519 VB denotes is
T15744 28520-28531 VB denotes compromised
T15745 28532-28534 IN denotes in
T15746 28535-28537 NN denotes RA
T15747 28538-28546 NN denotes patients
T15748 28548-28555 IN denotes Because
T15749 28556-28558 IN denotes of
T15750 28559-28562 PRP-DOLLAR- denotes its
T15751 28563-28573 JJ denotes restricted
T15752 28574-28584 NN denotes expression
T15753 28585-28592 NN denotes pattern
T15754 28592-28593 -COMMA- denotes ,
T15755 28594-28600 NN denotes SIGIRR
T15756 28601-28604 MD denotes may
T15757 28605-28609 RB denotes also
T15758 28610-28612 VB denotes be
T15759 28613-28615 DT denotes an
T15760 28616-28627 JJ denotes interesting
T15761 28628-28639 JJ denotes therapeutic
T15762 28640-28646 NN denotes target
T15763 28647-28649 IN denotes in
T15764 28650-28652 NN denotes RA
T16430 28655-28658 NN denotes TNF
T16431 28659-28678 JJ denotes receptor-associated
T16432 28679-28685 NN denotes factor
T16433 28686-28687 CD denotes 1
T16434 28688-28693 NN denotes TRAF1
T16435 28694-28696 VB denotes is
T16436 28697-28698 DT denotes a
T16437 28699-28705 JJ denotes unique
T16438 28706-28712 NN denotes member
T16439 28713-28715 IN denotes of
T16440 28716-28719 DT denotes the
T16441 28720-28724 NN denotes TRAF
T16442 28725-28732 NN denotes protein
T16443 28733-28739 NN denotes family
T16444 28740-28747 IN denotes because
T16445 28748-28750 PRP denotes it
T16446 28751-28756 VB denotes lacks
T16447 28757-28758 DT denotes a
T16448 28759-28763 NN denotes RING
T16449 28764-28770 NN denotes finger
T16450 28771-28777 NN denotes domain
T16451 28778-28781 CC denotes and
T16452 28782-28791 RB denotes therefore
T16453 28792-28797 VB denotes lacks
T16454 28798-28807 NN denotes ubiquitin
T16455 28808-28814 NN denotes ligase
T16456 28815-28823 NN denotes activity
T16457 28825-28837 VB denotes Accumulating
T16458 28838-28842 NN denotes data
T16459 28843-28850 VB denotes support
T16460 28851-28852 DT denotes a
T16461 28853-28857 NN denotes role
T16462 28858-28861 IN denotes for
T16463 28862-28867 NN denotes TRAF1
T16464 28868-28870 IN denotes as
T16465 28871-28875 CC denotes both
T16466 28876-28877 DT denotes a
T16467 28878-28886 JJ denotes negative
T16468 28887-28890 CC denotes and
T16469 28891-28892 DT denotes a
T16470 28893-28901 JJ denotes positive
T16471 28902-28911 NN denotes modulator
T16472 28912-28914 IN denotes of
T16473 28915-28920 NN denotes NF-κB
T16474 28921-28931 NN denotes signalling
T16475 28932-28934 IN denotes by
T16476 28935-28942 JJ denotes certain
T16477 28943-28946 NN denotes TNF
T16478 28947-28953 NN denotes family
T16479 28954-28963 NN denotes receptors
T16480 28963-28964 -COMMA- denotes ,
T16481 28965-28973 RB denotes possibly
T16482 28974-28976 IN denotes in
T16483 28977-28978 DT denotes a
T16484 28979-28998 JJ denotes cell-type-dependent
T16485 28999-29005 NN denotes manner
T16486 29006-29007 -LRB- denotes [
T16487 29007-29012 CD denotes 71,72
T16488 29012-29013 -RRB- denotes ]
T16489 29015-29025 NN denotes Expression
T16490 29026-29028 IN denotes of
T16491 29029-29034 NN denotes TRAF1
T16492 29035-29037 VB denotes is
T16493 29038-29047 JJ denotes inducible
T16494 29048-29050 IN denotes by
T16495 29051-29054 NN denotes TNF
T16496 29055-29058 CC denotes and
T16497 29059-29073 NN denotes overexpression
T16498 29074-29076 IN denotes of
T16499 29077-29082 NN denotes TRAF1
T16500 29083-29091 VB denotes inhibits
T16501 29092-29103 JJ denotes TNF-induced
T16502 29104-29109 NN denotes NF-κB
T16503 29110-29120 NN denotes activation
T16504 29122-29137 JJ denotes TRAF1-deficient
T16505 29138-29139 NN denotes T
T16506 29140-29145 NN denotes cells
T16507 29146-29149 VB denotes are
T16508 29150-29166 JJ denotes hyper-responsive
T16509 29167-29169 TO denotes to
T16510 29170-29173 NN denotes TNF
T16511 29173-29174 -COMMA- denotes ,
T16512 29175-29179 IN denotes with
T16513 29180-29188 VB denotes enhanced
T16514 29189-29202 NN denotes proliferation
T16515 29203-29206 CC denotes and
T16516 29207-29217 NN denotes activation
T16517 29218-29220 IN denotes of
T16518 29221-29224 DT denotes the
T16519 29225-29230 NN denotes NF-κB
T16520 29231-29241 NN denotes signalling
T16521 29242-29249 NN denotes pathway
T16522 29251-29256 NN denotes TRAF1
T16523 29257-29261 RB denotes also
T16524 29262-29271 VB denotes functions
T16525 29272-29274 IN denotes as
T16526 29275-29276 DT denotes a
T16527 29277-29285 JJ denotes negative
T16528 29286-29295 NN denotes regulator
T16529 29296-29298 IN denotes of
T16530 29299-29311 JJ denotes CD40-induced
T16531 29312-29317 NN denotes NF-κB
T16532 29318-29328 NN denotes activation
T16533 29330-29345 JJ denotes TRAF1-deficient
T16534 29346-29355 JJ denotes dendritic
T16535 29356-29361 NN denotes cells
T16536 29361-29362 -COMMA- denotes ,
T16537 29363-29370 RB denotes however
T16538 29370-29371 -COMMA- denotes ,
T16539 29372-29376 VB denotes show
T16540 29377-29387 VB denotes attenuated
T16541 29388-29397 NN denotes responses
T16542 29398-29400 TO denotes to
T16543 29401-29410 JJ denotes secondary
T16544 29411-29422 NN denotes stimulation
T16545 29423-29425 IN denotes by
T16546 29426-29441 JJ denotes TRAF2-dependent
T16547 29442-29449 NN denotes factors
T16548 29449-29450 -COMMA- denotes ,
T16549 29451-29461 VB denotes suggesting
T16550 29462-29463 DT denotes a
T16551 29464-29472 JJ denotes positive
T16552 29473-29483 JJ denotes regulatory
T16553 29484-29488 NN denotes role
T16554 29489-29491 IN denotes in
T16555 29492-29497 DT denotes these
T16556 29498-29503 NN denotes cells
T16557 29505-29508 DT denotes The
T16558 29509-29518 NN denotes mechanism
T16559 29519-29521 IN denotes by
T16560 29522-29527 WDT denotes which
T16561 29528-29533 NN denotes TRAF1
T16562 29534-29543 VB denotes modulates
T16563 29544-29547 NF- denotes NF-
T16564 29548-29550 NN denotes κB
T16565 29551-29561 NN denotes activation
T16566 29562-29564 VB denotes is
T16567 29565-29570 RB denotes still
T16568 29571-29578 JJ denotes unclear
T16569 29580-29584 RB denotes Most
T16570 29585-29593 RB denotes probably
T16571 29593-29594 -COMMA- denotes ,
T16572 29595-29600 NN denotes TRAF1
T16573 29601-29609 VB denotes competes
T16574 29610-29614 IN denotes with
T16575 29615-29619 NN denotes TRAF
T16576 29620-29626 NN denotes family
T16577 29627-29634 NN denotes members
T16578 29635-29638 IN denotes for
T16579 29639-29646 VB denotes binding
T16580 29647-29649 TO denotes to
T16581 29650-29653 DT denotes the
T16582 29654-29662 NN denotes receptor
T16583 29663-29665 CC denotes or
T16584 29666-29671 JJ denotes other
T16585 29672-29682 NN denotes signalling
T16586 29683-29691 NN denotes proteins
T16587 29693-29706 RB denotes Alternatively
T16588 29706-29707 -COMMA- denotes ,
T16589 29708-29713 NN denotes TRAF1
T16590 29714-29719 MD denotes might
T16591 29720-29727 VB denotes recruit
T16592 29728-29731 NN denotes A20
T16593 29732-29736 IN denotes with
T16594 29737-29742 WDT denotes which
T16595 29743-29745 PRP denotes it
T16596 29746-29749 MD denotes can
T16597 29750-29760 RB denotes physically
T16598 29761-29769 VB denotes interact
T16599 29770-29771 -LRB- denotes [
T16600 29771-29773 CD denotes 73
T16601 29773-29774 -RRB- denotes ]
T16602 29776-29777 DT denotes A
T16603 29778-29789 JJ denotes genome-wide
T16604 29790-29801 NN denotes association
T16605 29802-29807 NN denotes study
T16606 29808-29817 VB denotes examining
T16607 29818-29822 JJ denotes more
T16608 29823-29827 IN denotes than
T16609 29828-29835 CD denotes 300,000
T16610 29836-29840 NN denotes SNPs
T16611 29841-29846 IN denotes among
T16612 29847-29860 RB denotes approximately
T16613 29861-29866 CD denotes 1,500
T16614 29867-29888 JJ denotes autoantibody-positive
T16615 29889-29891 NN denotes RA
T16616 29892-29897 NN denotes cases
T16617 29898-29901 CC denotes and
T16618 29902-29907 CD denotes 1,800
T16619 29908-29916 NN denotes controls
T16620 29917-29927 VB denotes identified
T16621 29928-29929 DT denotes a
T16622 29930-29937 JJ denotes genetic
T16623 29938-29947 NN denotes variation
T16624 29948-29950 IN denotes at
T16625 29951-29954 DT denotes the
T16626 29955-29971 NN denotes TRAF1-complement
T16627 29972-29981 NN denotes component
T16628 29982-29983 CD denotes 5
T16629 29984-29989 NN denotes locus
T16630 29990-29992 IN denotes as
T16631 29993-29995 DT denotes an
T16632 29996-30005 JJ denotes important
T16633 30006-30008 NN denotes RA
T16634 30009-30013 NN denotes risk
T16635 30014-30019 NN denotes locus
T16636 30020-30021 -LRB- denotes [
T16637 30021-30023 CD denotes 74
T16638 30023-30024 -RRB- denotes ]
T16639 30026-30036 JJ denotes Subsequent
T16640 30037-30041 NN denotes work
T16641 30042-30051 VB denotes indicates
T16642 30052-30056 IN denotes that
T16643 30057-30062 NN denotes TRAF1
T16644 30063-30065 VB denotes is
T16645 30066-30070 RB denotes more
T16646 30071-30077 JJ denotes likely
T16647 30078-30080 TO denotes to
T16648 30081-30083 VB denotes be
T16649 30084-30087 DT denotes the
T16650 30088-30097 JJ denotes causative
T16651 30098-30103 NN denotes locus
T16652 30104-30105 -LRB- denotes [
T16653 30105-30107 CD denotes 75
T16654 30107-30108 -RRB- denotes ]
T16655 30110-30116 JJ denotes Recent
T16656 30117-30121 NN denotes work
T16657 30122-30124 IN denotes in
T16658 30125-30126 DT denotes a
T16659 30127-30133 JJ denotes Korean
T16660 30134-30144 NN denotes population
T16661 30145-30149 RB denotes also
T16662 30150-30162 VB denotes demonstrates
T16663 30163-30170 JJ denotes genetic
T16664 30171-30182 NN denotes association
T16665 30183-30185 IN denotes of
T16666 30186-30189 DT denotes the
T16667 30190-30195 NN denotes TRAF1
T16668 30196-30202 NN denotes region
T16669 30203-30207 IN denotes with
T16670 30208-30210 NN denotes RA
T16671 30211-30212 -LRB- denotes [
T16672 30212-30214 CD denotes 76
T16673 30214-30215 -RRB- denotes ]
T17543 30218-30227 NN denotes microRNAs
T17544 30228-30234 NN denotes miRNAs
T17545 30235-30238 VB denotes are
T17546 30239-30247 RB denotes recently
T17547 30248-30258 VB denotes discovered
T17548 30259-30269 NN denotes regulators
T17549 30270-30272 IN denotes of
T17550 30273-30277 NN denotes gene
T17551 30278-30288 NN denotes expression
T17552 30289-30292 CC denotes and
T17553 30293-30302 VB denotes represent
T17554 30303-30304 DT denotes a
T17555 30305-30310 NN denotes class
T17556 30311-30313 IN denotes of
T17557 30314-30323 JJ denotes noncoding
T17558 30324-30327 NN denotes RNA
T17559 30328-30337 NN denotes molecules
T17560 30338-30347 JJ denotes essential
T17561 30348-30350 IN denotes in
T17562 30351-30355 JJ denotes many
T17563 30356-30364 JJ denotes cellular
T17564 30365-30368 CC denotes and
T17565 30369-30382 JJ denotes developmental
T17566 30383-30392 NN denotes processes
T17567 30392-30393 -COMMA- denotes ,
T17568 30394-30403 VB denotes including
T17569 30404-30410 JJ denotes immune
T17570 30411-30420 NN denotes responses
T17571 30421-30424 CC denotes and
T17572 30425-30437 NN denotes inflammation
T17573 30439-30443 PRP denotes They
T17574 30444-30448 VB denotes bind
T17575 30449-30452 DT denotes the
T17576 30453-30459 NN denotes 3'-UTR
T17577 30460-30462 IN denotes of
T17578 30463-30469 NN denotes target
T17579 30470-30475 NN denotes mRNAs
T17580 30476-30483 VB denotes leading
T17581 30484-30486 TO denotes to
T17582 30487-30490 DT denotes the
T17583 30491-30501 NN denotes repression
T17584 30502-30504 IN denotes of
T17585 30505-30512 NN denotes protein
T17586 30513-30523 NN denotes expression
T17587 30524-30527 CC denotes and
T17588 30528-30531 DT denotes the
T17589 30532-30541 NN denotes promotion
T17590 30542-30544 IN denotes of
T17591 30545-30551 NN denotes target
T17592 30552-30556 NN denotes mRNA
T17593 30557-30568 NN denotes degradation
T17594 30569-30570 -LRB- denotes [
T17595 30570-30572 CD denotes 77
T17596 30572-30573 -RRB- denotes ]
T17597 30575-30585 NN denotes miR-146a/b
T17598 30586-30589 CC denotes and
T17599 30590-30597 NN denotes miR-155
T17600 30598-30601 VB denotes are
T17601 30602-30604 IN denotes of
T17602 30605-30615 JJ denotes particular
T17603 30616-30624 NN denotes interest
T17604 30625-30628 IN denotes for
T17605 30629-30641 JJ denotes inflammatory
T17606 30642-30652 NN denotes signalling
T17607 30653-30655 TO denotes to
T17608 30656-30661 NN denotes NF-κB
T17609 30661-30662 -COMMA- denotes ,
T17610 30663-30668 IN denotes since
T17611 30669-30674 DT denotes these
T17612 30675-30681 NN denotes miRNAs
T17613 30682-30685 MD denotes can
T17614 30686-30688 VB denotes be
T17615 30689-30696 VB denotes induced
T17616 30697-30699 IN denotes by
T17617 30700-30712 JJ denotes inflammatory
T17618 30713-30720 NN denotes stimuli
T17619 30721-30725 JJ denotes such
T17620 30726-30728 IN denotes as
T17621 30729-30734 NN denotes IL-1β
T17622 30734-30735 -COMMA- denotes ,
T17623 30736-30739 NN denotes TNF
T17624 30740-30743 CC denotes and
T17625 30744-30748 NN denotes TLRs
T17626 30749-30750 -LRB- denotes [
T17627 30750-30755 CD denotes 78,79
T17628 30755-30756 -RRB- denotes ]
T17629 30758-30760 IN denotes In
T17630 30761-30769 NN denotes addition
T17631 30769-30770 -COMMA- denotes ,
T17632 30771-30779 NN denotes miR-146a
T17633 30780-30782 VB denotes is
T17634 30783-30785 DT denotes an
T17635 30786-30801 JJ denotes NF-κB-dependent
T17636 30802-30806 NN denotes gene
T17637 30806-30807 -COMMA- denotes ,
T17638 30808-30811 CC denotes and
T17639 30812-30815 DT denotes the
T17640 30816-30821 NN denotes NF-κB
T17641 30822-30832 NN denotes signalling
T17642 30833-30842 NN denotes molecules
T17643 30843-30848 NN denotes IRAK1
T17644 30849-30852 CC denotes and
T17645 30853-30858 NN denotes TRAF6
T17646 30859-30863 VB denotes were
T17647 30864-30874 VB denotes identified
T17648 30875-30877 IN denotes as
T17649 30878-30884 NN denotes target
T17650 30885-30890 NN denotes genes
T17651 30891-30893 IN denotes of
T17652 30894-30902 NN denotes miR-146a
T17653 30903-30904 -LRB- denotes [
T17654 30904-30906 CD denotes 78
T17655 30906-30907 -RRB- denotes ]
T17656 30908-30909 -LRB- denotes (
T17657 30909-30915 NN denotes Figure
T17658 30916-30917 CD denotes 1
T17659 30917-30918 -RRB- denotes )
T17660 30920-30929 RB denotes Similarly
T17661 30929-30930 -COMMA- denotes ,
T17662 30931-30938 NN denotes miR-155
T17663 30939-30942 VB denotes was
T17664 30943-30948 VB denotes shown
T17665 30949-30951 TO denotes to
T17666 30952-30958 NN denotes target
T17667 30959-30970 NN denotes transcripts
T17668 30971-30974 IN denotes for
T17669 30975-30978 DT denotes the
T17670 30979-30984 NN denotes NF-κB
T17671 30985-30995 NN denotes signalling
T17672 30996-31005 NN denotes molecules
T17673 31006-31010 NN denotes IKKε
T17674 31011-31014 CC denotes and
T17675 31015-31019 NN denotes RIP1
T17676 31020-31021 -LRB- denotes [
T17677 31021-31026 CD denotes 79,80
T17678 31026-31027 -RRB- denotes ]
T17679 31029-31036 RB denotes Notably
T17680 31036-31037 -COMMA- denotes ,
T17681 31038-31042 CC denotes both
T17682 31043-31050 NN denotes miR-146
T17683 31051-31054 CC denotes and
T17684 31055-31062 NN denotes miR-155
T17685 31063-31066 VB denotes are
T17686 31067-31076 VB denotes expressed
T17687 31077-31079 IN denotes at
T17688 31080-31086 JJ denotes higher
T17689 31087-31093 NN denotes levels
T17690 31094-31096 IN denotes in
T17691 31097-31099 NN denotes RA
T17692 31100-31108 JJ denotes synovial
T17693 31109-31120 NN denotes fibroblasts
T17694 31121-31124 CC denotes and
T17695 31125-31133 JJ denotes synovial
T17696 31134-31140 NN denotes tissue
T17697 31141-31142 -LRB- denotes [
T17698 31142-31147 CD denotes 81,82
T17699 31147-31148 -RRB- denotes ]
T17700 31148-31149 -COMMA- denotes ,
T17701 31150-31152 RB denotes as
T17702 31153-31157 RB denotes well
T17703 31158-31160 IN denotes as
T17704 31161-31163 IN denotes in
T17705 31164-31174 JJ denotes peripheral
T17706 31175-31180 NN denotes blood
T17707 31181-31192 JJ denotes mononuclear
T17708 31193-31198 NN denotes cells
T17709 31199-31201 IN denotes of
T17710 31202-31204 NN denotes RA
T17711 31205-31213 NN denotes patients
T17712 31214-31215 -LRB- denotes [
T17713 31215-31217 CD denotes 83
T17714 31217-31218 -RRB- denotes ]
T17715 31218-31226 NN denotes . miR-14
T17716 31226-31228 VB denotes 6a
T17717 31229-31233 RB denotes is a
T17718 31233-31246 VB denotes lso overexpre
T17719 31246-31248 IN denotes ss
T17720 31248-31252 JJ denotes ed i
T17721 31252-31255 CC denotes n C
T17722 31255-31270 JJ denotes D4+ and IL-17-p
T17723 31270-31271 NN denotes r
T17724 31271-31276 NN denotes oduci
T17725 31276-31280 IN denotes ng T
T17726 31281-31283 NN denotes ce
T17727 31283-31291 NN denotes lls from
T17728 31292-31293 -LRB- denotes R
T17729 31293-31298 CD denotes A pat
T17730 31298-31299 -RRB- denotes i
T17731 31313-31326 RB denotes Interestingly
T17732 31326-31327 -COMMA- denotes ,
T17733 31328-31329 DT denotes a
T17734 31330-31342 NN denotes polymorphism
T17735 31343-31345 IN denotes in
T17736 31346-31349 DT denotes the
T17737 31350-31356 NN denotes 3'-UTR
T17738 31357-31359 IN denotes of
T17739 31360-31363 DT denotes the
T17740 31364-31372 NN denotes miR-146a
T17741 31373-31379 NN denotes target
T17742 31380-31384 NN denotes gene
T17743 31385-31388 VB denotes was
T17744 31389-31397 RB denotes recently
T17745 31398-31403 VB denotes shown
T17746 31404-31406 TO denotes to
T17747 31407-31409 VB denotes be
T17748 31410-31420 VB denotes associated
T17749 31421-31425 IN denotes with
T17750 31426-31428 NN denotes RA
T17751 31429-31443 NN denotes susceptibility
T17752 31444-31445 -LRB- denotes [
T17753 31445-31447 CD denotes 86
T17754 31447-31448 -RRB- denotes ]
T17755 31448-31455 NN denotes . miR-1
T17756 31455-31469 NN denotes 55 overexpress
T17757 31469-31471 IN denotes io
T17758 31471-31479 JJ denotes n in syn
T17759 31479-31490 NN denotes ovial fibro
T17760 31490-31493 VB denotes bla
T17761 31493-31497 JJ denotes sts
T17762 31497-31499 TO denotes wa
T17763 31499-31506 VB denotes s able
T17764 31506-31509 DT denotes to
T17765 31509-31512 NN denotes pre
T17766 31512-31515 CC denotes ven
T17767 31515-31533 JJ denotes t the TLR and cyto
T17768 31533-31543 NN denotes kine-induc
T17769 31543-31545 IN denotes ib
T17770 31545-31553 JJ denotes le expre
T17771 31553-31559 NN denotes ssion
T17772 31559-31577 NN denotes of specific matrix
T17773 31578-31582 WDT denotes meta
T17774 31582-31589 VB denotes lloprot
T17775 31589-31595 NN denotes einase
T17776 31595-31606 NN denotes s that medi
T17777 31606-31608 IN denotes at
T17778 31608-31610 NN denotes e
T17779 31610-31611 -LRB- denotes t
T17780 31611-31613 CD denotes is
T17781 31613-31614 -RRB- denotes s
T17782 31641-31649 RB denotes Moreover
T17783 31649-31650 -COMMA- denotes ,
T17784 31651-31658 NN denotes miR-155
T17785 31659-31662 VB denotes was
T17786 31663-31668 VB denotes shown
T17787 31669-31671 TO denotes to
T17788 31672-31679 VB denotes promote
T17789 31680-31683 NN denotes TNF
T17790 31684-31694 NN denotes production
T17791 31694-31695 -COMMA- denotes ,
T17792 31696-31697 DT denotes a
T17793 31698-31701 JJ denotes key
T17794 31702-31709 NN denotes process
T17795 31710-31712 IN denotes in
T17796 31713-31716 DT denotes the
T17797 31717-31729 NN denotes pathogenesis
T17798 31730-31732 IN denotes of
T17799 31733-31735 NN denotes RA
T17800 31736-31737 -LRB- denotes [
T17801 31737-31739 CD denotes 87
T17802 31739-31740 -RRB- denotes ]
T17803 31740-31747 NN denotes . miR-1
T17804 31747-31750 CC denotes 46
T17805 31750-31757 NN denotes and miR
T17806 31757-31760 MD denotes -15
T17807 31760-31769 RB denotes 5 may the
T17808 31769-31771 VB denotes re
T17809 31771-31780 JJ denotes fore be i
T17810 31780-31788 JJ denotes mportant
T17811 31789-31799 NN denotes negative r
T17812 31799-31801 IN denotes eg
T17813 31801-31813 NN denotes ulators of i
T17814 31813-31815 IN denotes nf
T17815 31815-31817 NN denotes la
T17816 31817-31820 CC denotes mma
T17817 31820-31825 PRP-DOLLAR- denotes tion
T17818 31825-31834 NN denotes in RA and
T17819 31835-31838 IN denotes the
T17820 31838-31841 DT denotes ir
T17821 31841-31852 NN denotes potential f
T17822 31852-31854 IN denotes or
T17823 31855-31858 JJ denotes the
T17824 31859-31869 NN denotes developmen
T17825 31869-31871 VB denotes t
T17826 31871-31882 JJ denotes of new trea
T17827 31905-31907 IN denotes In
T17828 31908-31916 NN denotes addition
T17829 31916-31917 -COMMA- denotes ,
T17830 31918-31923 PRP-DOLLAR- denotes their
T17831 31924-31933 VB denotes increased
T17832 31934-31944 NN denotes expression
T17833 31945-31947 IN denotes in
T17834 31948-31950 NN denotes RA
T17835 31951-31959 NN denotes patients
T17836 31960-31962 VB denotes is
T17837 31963-31974 RB denotes potentially
T17838 31975-31981 JJ denotes useful
T17839 31982-31984 IN denotes as
T17840 31985-31986 DT denotes a
T17841 31987-31993 NN denotes marker
T17842 31994-31997 IN denotes for
T17843 31998-32005 NN denotes disease
T17844 32006-32015 NN denotes diagnosis
T17845 32015-32016 -COMMA- denotes ,
T17846 32017-32028 NN denotes progression
T17847 32028-32029 -COMMA- denotes ,
T17848 32030-32032 CC denotes or
T17849 32033-32042 NN denotes treatment
T17850 32043-32051 NN denotes efficacy
T17851 32052-32053 -LRB- denotes [
T17852 32053-32055 CD denotes 88
T17853 32055-32056 -RRB- denotes ]
T17854 32056-32057 -COMMA- denotes ,
T17855 32058-32061 CC denotes but
T17856 32062-32066 DT denotes this
T17857 32067-32071 MD denotes will
T17858 32072-32079 VB denotes require
T17859 32080-32092 NN denotes confirmation
T17860 32093-32098 VB denotes using
T17861 32099-32100 DT denotes a
T17862 32101-32106 JJ denotes large
T17863 32107-32110 CC denotes and
T17864 32111-32123 JJ denotes well-defined
T17865 32124-32130 NN denotes cohort
T17866 32132-32139 IN denotes Besides
T17867 32140-32147 NN denotes miR-146
T17868 32148-32151 CC denotes and
T17869 32152-32159 NN denotes miR-155
T17870 32159-32160 -COMMA- denotes ,
T17871 32161-32162 DT denotes a
T17872 32163-32169 NN denotes number
T17873 32170-32172 IN denotes of
T17874 32173-32178 JJ denotes other
T17875 32179-32185 NN denotes miRNAs
T17876 32186-32190 IN denotes with
T17877 32191-32192 DT denotes a
T17878 32193-32202 JJ denotes potential
T17879 32203-32207 NN denotes role
T17880 32208-32210 IN denotes in
T17881 32211-32214 DT denotes the
T17882 32215-32222 NN denotes control
T17883 32223-32225 IN denotes of
T17884 32226-32241 JJ denotes NF-κB-dependent
T17885 32242-32254 JJ denotes inflammatory
T17886 32255-32264 NN denotes responses
T17887 32265-32267 IN denotes in
T17888 32268-32270 NN denotes RA
T17889 32271-32280 NN denotes pathology
T17890 32281-32285 VB denotes were
T17891 32286-32294 RB denotes recently
T17892 32295-32305 VB denotes identified
T17893 32307-32309 IN denotes In
T17894 32310-32314 DT denotes this
T17895 32315-32322 NN denotes context
T17896 32322-32323 -COMMA- denotes ,
T17897 32324-32332 NN denotes miR-124a
T17898 32333-32334 -COLON- denotes -
T17899 32335-32336 DT denotes a
T17900 32337-32340 JJ denotes key
T17901 32341-32350 NN denotes regulator
T17902 32351-32353 IN denotes of
T17903 32354-32357 DT denotes the
T17904 32358-32367 NN denotes chemokine
T17905 32368-32376 NN denotes monocyte
T17906 32377-32392 NN denotes chemoattractant
T17907 32393-32400 NN denotes protein
T17908 32401-32402 CD denotes 1
T17909 32403-32404 -COLON- denotes -
T17910 32405-32408 VB denotes was
T17911 32409-32414 VB denotes shown
T17912 32415-32417 TO denotes to
T17913 32418-32420 VB denotes be
T17914 32421-32430 VB denotes decreased
T17915 32431-32433 IN denotes in
T17916 32434-32446 NN denotes synoviocytes
T17917 32447-32451 IN denotes from
T17918 32452-32454 NN denotes RA
T17919 32455-32463 NN denotes patients
T17920 32464-32465 -LRB- denotes [
T17921 32465-32467 CD denotes 89
T17922 32467-32468 -RRB- denotes ]
T17923 32470-32479 RB denotes Similarly
T17924 32479-32480 -COMMA- denotes ,
T17925 32481-32489 JJ denotes elevated
T17926 32490-32496 NN denotes levels
T17927 32497-32499 IN denotes of
T17928 32500-32507 NN denotes miR-203
T17929 32508-32509 -COLON- denotes -
T17930 32510-32517 VB denotes leading
T17931 32518-32520 TO denotes to
T17932 32521-32530 VB denotes increased
T17933 32531-32540 NN denotes secretion
T17934 32541-32543 IN denotes of
T17935 32544-32550 NN denotes matrix
T17936 32551-32570 NN denotes metalloproteinase-1
T17937 32571-32574 CC denotes and
T17938 32575-32579 NN denotes IL-6
T17939 32580-32581 -COLON- denotes -
T17940 32582-32586 VB denotes were
T17941 32587-32595 VB denotes detected
T17942 32596-32598 IN denotes in
T17943 32599-32601 NN denotes RA
T17944 32602-32610 JJ denotes synovial
T17945 32611-32622 NN denotes fibroblasts
T17946 32623-32624 -LRB- denotes [
T17947 32624-32626 CD denotes 90
T17948 32626-32627 -RRB- denotes ]
T17949 32629-32636 RB denotes Finally
T17950 32636-32637 -COMMA- denotes ,
T17951 32638-32644 NN denotes miR-16
T17952 32644-32645 -COMMA- denotes ,
T17953 32646-32653 NN denotes miR-132
T17954 32653-32654 -COMMA- denotes ,
T17955 32655-32658 CC denotes and
T17956 32659-32666 NN denotes miR-223
T17957 32667-32671 VB denotes were
T17958 32672-32676 RB denotes also
T17959 32677-32682 VB denotes shown
T17960 32683-32685 TO denotes to
T17961 32686-32690 VB denotes have
T17962 32691-32693 DT denotes an
T17963 32694-32701 VB denotes altered
T17964 32702-32712 NN denotes expression
T17965 32713-32715 IN denotes in
T17966 32716-32718 NN denotes RA
T17967 32719-32727 NN denotes patients
T17968 32727-32728 -COMMA- denotes ,
T17969 32729-32739 VB denotes indicating
T17970 32740-32745 PRP-DOLLAR- denotes their
T17971 32746-32755 NN denotes potential
T17972 32756-32758 IN denotes as
T17973 32759-32769 JJ denotes diagnostic
T17974 32770-32780 NN denotes biomarkers
T17975 32781-32784 IN denotes for
T17976 32785-32797 NN denotes pathogenesis
T17977 32798-32799 -LRB- denotes [
T17978 32799-32807 CD denotes 83,88,91
T17979 32807-32808 -RRB- denotes ]
T18903 32823-32826 DT denotes The
T18904 32827-32832 NN denotes NF-κB
T18905 32833-32839 NN denotes family
T18906 32840-32842 IN denotes of
T18907 32843-32856 NN denotes transcription
T18908 32857-32864 NN denotes factors
T18909 32865-32870 VB denotes plays
T18910 32871-32878 JJ denotes crucial
T18911 32879-32884 NN denotes roles
T18912 32885-32887 IN denotes in
T18913 32888-32891 DT denotes the
T18914 32892-32904 JJ denotes inflammatory
T18915 32905-32914 NN denotes processes
T18916 32915-32917 IN denotes in
T18917 32918-32920 NN denotes RA
T18918 32921-32928 VB denotes leading
T18919 32929-32931 TO denotes to
T18920 32932-32941 NN denotes cartilage
T18921 32942-32945 CC denotes and
T18922 32946-32950 NN denotes bone
T18923 32951-32962 NN denotes destruction
T18924 32964-32971 VB denotes Keeping
T18925 32972-32977 NN denotes NF-κB
T18926 32978-32988 NN denotes activation
T18927 32989-32994 IN denotes under
T18928 32995-33002 NN denotes control
T18929 33003-33006 MD denotes can
T18930 33007-33011 RB denotes thus
T18931 33012-33014 VB denotes be
T18932 33015-33019 RB denotes very
T18933 33020-33029 JJ denotes important
T18934 33030-33033 IN denotes for
T18935 33034-33037 DT denotes the
T18936 33038-33044 NN denotes design
T18937 33045-33047 IN denotes of
T18938 33048-33056 JJ denotes specific
T18939 33057-33069 NN denotes therapeutics
T18940 33071-33074 DT denotes The
T18941 33075-33084 NN denotes existence
T18942 33085-33087 IN denotes of
T18943 33088-33096 JJ denotes multiple
T18944 33097-33105 JJ denotes negative
T18945 33106-33116 NN denotes regulators
T18946 33117-33125 VB denotes ensuring
T18947 33126-33127 DT denotes a
T18948 33128-33133 JJ denotes tight
T18949 33134-33144 NN denotes regulation
T18950 33145-33147 IN denotes of
T18951 33148-33151 DT denotes the
T18952 33152-33157 NN denotes NF-κB
T18953 33158-33165 NN denotes pathway
T18954 33165-33166 -COMMA- denotes ,
T18955 33167-33174 RB denotes however
T18956 33174-33175 -COMMA- denotes ,
T18957 33176-33182 VB denotes raises
T18958 33183-33186 DT denotes the
T18959 33187-33195 NN denotes question
T18960 33196-33198 IN denotes of
T18961 33199-33202 DT denotes the
T18962 33203-33211 JJ denotes specific
T18963 33212-33216 NN denotes role
T18964 33217-33219 IN denotes of
T18965 33220-33224 DT denotes each
T18966 33225-33227 IN denotes of
T18967 33228-33233 DT denotes these
T18968 33234-33244 NN denotes regulators
T18969 33245-33248 CC denotes and
T18970 33249-33252 DT denotes the
T18971 33253-33265 NN denotes relationship
T18972 33266-33273 IN denotes between
T18973 33274-33278 PRP denotes them
T18974 33280-33282 IN denotes In
T18975 33283-33291 NN denotes addition
T18976 33291-33292 -COMMA- denotes ,
T18977 33293-33298 VB denotes given
T18978 33299-33302 DT denotes the
T18979 33303-33309 NN denotes number
T18980 33310-33312 IN denotes of
T18981 33313-33319 NN denotes miRNAs
T18982 33320-33322 IN denotes in
T18983 33323-33329 NN denotes humans
T18984 33330-33333 CC denotes and
T18985 33334-33337 DT denotes the
T18986 33338-33346 JJ denotes multiple
T18987 33347-33352 NN denotes mRNAs
T18988 33353-33357 PRP denotes they
T18989 33358-33364 VB denotes target
T18990 33364-33365 -COMMA- denotes ,
T18991 33366-33373 JJ denotes intense
T18992 33374-33384 NN denotes complexity
T18993 33385-33388 MD denotes can
T18994 33389-33391 VB denotes be
T18995 33392-33400 VB denotes expected
T18996 33402-33405 WRB denotes How
T18997 33406-33409 PDT denotes all
T18998 33410-33415 DT denotes these
T18999 33416-33426 JJ denotes regulatory
T19000 33427-33434 NN denotes signals
T19001 33435-33438 VB denotes are
T19002 33439-33449 PRP denotes themselves
T19003 33450-33459 VB denotes regulated
T19004 33460-33464 MD denotes will
T19005 33465-33467 VB denotes be
T19006 33468-33470 DT denotes an
T19007 33471-33480 JJ denotes important
T19008 33481-33489 NN denotes question
T19009 33490-33492 IN denotes in
T19010 33493-33498 NN denotes order
T19011 33499-33501 TO denotes to
T19012 33502-33509 VB denotes clarify
T19013 33510-33513 WRB denotes how
T19014 33514-33519 NN denotes NF-κB
T19015 33520-33530 NN denotes signalling
T19016 33531-33533 VB denotes is
T19017 33534-33543 VB denotes organised
T19018 33543-33544 -COMMA- denotes ,
T19019 33545-33548 CC denotes and
T19020 33548-33549 -COMMA- denotes ,
T19021 33550-33554 RB denotes more
T19022 33555-33566 RB denotes importantly
T19023 33566-33567 -COMMA- denotes ,
T19024 33568-33571 WRB denotes how
T19025 33572-33576 DT denotes this
T19026 33577-33586 NN denotes knowledge
T19027 33587-33590 MD denotes may
T19028 33591-33595 VB denotes lead
T19029 33596-33598 TO denotes to
T19030 33599-33602 JJ denotes new
T19031 33603-33613 NN denotes treatments
T19032 33614-33617 IN denotes for
T19033 33618-33630 JJ denotes inflammatory
T19034 33631-33639 NN denotes diseases
T19035 33640-33644 JJ denotes such
T19036 33645-33647 IN denotes as
T19037 33648-33650 NN denotes RA
R1 T6 T5 arg1Of regulation,Negative
R10 T18 T15 arg1Of NF-κB,The
R10202 T15550 T15547 arg1Of protein,Single-immunoglobulin
R10203 T15550 T15548 arg1Of protein,IL-1
R10204 T15550 T15549 arg1Of protein,receptor-related
R10205 T15555 T15554 arg2Of SIGIRR,(
R10206 T15556 T15554 arg3Of ),(
R10207 T15557 T15551 arg1Of protein,Single-immunoglobulin
R10208 T15557 T15552 arg1Of protein,IL-1
R10209 T15557 T15553 arg1Of protein,receptor-related
R10210 T15557 T15554 arg1Of protein,(
R10211 T15557 T15558 arg1Of protein,","
R10212 T15557 T15559 arg1Of protein,also
R10213 T15557 T15560 arg2Of protein,known
R10214 T15557 T15564 arg1Of protein,is
R10215 T15560 T15561 arg1Of known,as
R10216 T15562 T15561 arg2Of TIR-8,as
R10217 T15564 T15563 arg1Of is,","
R10218 T15566 T15564 arg2Of member,is
R10219 T15566 T15565 arg1Of member,a
R10220 T15566 T15567 arg1Of member,of
R10221 T15570 T15567 arg2Of family,of
R10222 T15570 T15568 arg1Of family,the
R10223 T15570 T15569 arg1Of family,TLR/IL-1R
R10224 T15570 T15571 arg1Of family,that
R10225 T15570 T15572 arg1Of family,has
R10226 T15570 T15573 arg1Of family,been
R10227 T15570 T15575 arg2Of family,characterised
R10228 T15575 T15572 arg2Of characterised,has
R10229 T15575 T15573 arg2Of characterised,been
R10230 T15575 T15574 arg1Of characterised,extensively
R10231 T15575 T15576 arg1Of characterised,as
R10232 T15575 T15584 arg1Of characterised,","
R10233 T15575 T15586 arg1Of characterised,through
R10234 T15575 T15598 arg1Of characterised,[
R10235 T15575 T15601 arg1Of characterised,(
R10236 T15578 T15576 arg2Of inhibitor,as
R10237 T15578 T15577 arg1Of inhibitor,an
R10238 T15578 T15579 arg1Of inhibitor,of
R10239 T15580 T15581 arg1Of IL-1R,and
R10240 T15582 T15581 arg2Of TLR,and
R10241 T15583 T15579 arg2Of signalling,of
R10242 T15583 T15580 arg1Of signalling,IL-1R
R10243 T15583 T15582 arg1Of signalling,TLR
R10244 T15586 T15585 arg1Of through,probably
R10245 T15588 T15587 arg1Of interaction,direct
R10246 T15588 T15589 arg1Of interaction,with
R10247 T15588 T15594 arg1Of interaction,","
R10248 T15591 T15589 arg2Of receptors,with
R10249 T15591 T15590 arg1Of receptors,these
R10250 T15591 T15592 arg1Of receptors,","
R10251 T15593 T15592 arg2Of MyD88,","
R10252 T15594 T15596 arg1Of ",",or
R10253 T15595 T15594 arg2Of IRAK1,","
R10254 T15596 T15586 arg2Of or,through
R10255 T15597 T15596 arg2Of TRAF6,or
R10256 T15599 T15598 arg2Of 67,[
R10257 T15600 T15598 arg3Of ],[
R10258 T15602 T15601 arg2Of Figure,(
R10259 T15602 T15603 arg1Of Figure,1
R10260 T15604 T15601 arg3Of ),(
R10261 T15608 T15605 arg2Of role,Given
R10262 T15608 T15606 arg1Of role,the
R10263 T15608 T15607 arg1Of role,important
R10264 T15608 T15609 arg1Of role,of
R10265 T15608 T15614 arg1Of role,in
R10266 T15610 T15611 arg1Of IL-1R,and
R10267 T15612 T15611 arg2Of TLR,and
R10268 T15613 T15609 arg2Of signalling,of
R10269 T15613 T15610 arg1Of signalling,IL-1R
R10270 T15613 T15612 arg1Of signalling,TLR
R10271 T15617 T15614 arg2Of inflammation,in
R10272 T15617 T15615 arg1Of inflammation,the
R10273 T15617 T15616 arg1Of inflammation,chronic
R10274 T15617 T15618 arg2Of inflammation,observed
R10275 T15618 T15619 arg1Of observed,in
R10276 T15620 T15619 arg2Of RA,in
R10277 T15620 T15621 arg1Of RA,[
R10278 T15622 T15621 arg2Of 68,[
R10279 T15623 T15621 arg3Of ],[
R10280 T15627 T15625 arg1Of role,a
R10281 T15627 T15626 arg1Of role,regulatory
R10282 T15627 T15628 arg1Of role,for
R10283 T15627 T15630 arg1Of role,in
R10284 T15627 T15632 arg1Of role,is
R10285 T15627 T15634 arg1Of role,unlikely
R10286 T15629 T15628 arg2Of SIGIRR,for
R10287 T15631 T15630 arg2Of RA,in
R10288 T15632 T15605 arg1Of is,Given
R10289 T15632 T15624 arg1Of is,","
R10290 T15632 T15633 arg1Of is,not
R10291 T15634 T15632 arg2Of unlikely,is
R10292 T15635 T15636 arg1Of SIGIRR,has
R10293 T15635 T15643 arg1Of SIGIRR,being
R10294 T15635 T15644 arg2Of SIGIRR,expressed
R10295 T15636 T15642 arg1Of has,","
R10296 T15639 T15638 arg1Of restricted,very
R10297 T15641 T15636 arg2Of pattern,has
R10298 T15641 T15637 arg1Of pattern,a
R10299 T15641 T15639 arg1Of pattern,restricted
R10300 T15641 T15640 arg1Of pattern,expression
R10301 T15644 T15642 arg2Of expressed,","
R10302 T15644 T15643 arg2Of expressed,being
R10303 T15644 T15645 arg1Of expressed,in
R10304 T15644 T15657 arg1Of expressed,in
R10305 T15644 T15660 arg1Of expressed,[
R10306 T15645 T15655 arg1Of in,but
R10307 T15647 T15646 arg1Of cells,epithelial
R10308 T15647 T15648 arg1Of cells,","
R10309 T15648 T15650 arg1Of ",",and
R10310 T15649 T15648 arg2Of monocytes,","
R10311 T15650 T15645 arg2Of and,in
R10312 T15653 T15650 arg2Of cells,and
R10313 T15653 T15651 arg1Of cells,immature
R10314 T15653 T15652 arg1Of cells,dendritic
R10315 T15655 T15654 arg1Of but,","
R10316 T15657 T15655 arg2Of in,but
R10317 T15657 T15656 arg1Of in,not
R10318 T15659 T15657 arg2Of macro-phages,in
R10319 T15659 T15658 arg1Of macro-phages,mature
R10320 T15661 T15660 arg2Of "69,70",[
R10321 T15662 T15660 arg3Of ],[
R10322 T15666 T15665 arg1Of overexpression,SIGIRR
R10323 T15666 T15667 arg1Of overexpression,was
R10324 T15666 T15668 arg2Of overexpression,shown
R10325 T15666 T15670 arg1Of overexpression,inhibit
R10326 T15668 T15663 arg1Of shown,Recently
R10327 T15668 T15664 arg1Of shown,","
R10328 T15668 T15667 arg2Of shown,was
R10329 T15670 T15668 arg3Of inhibit,shown
R10330 T15670 T15669 arg1Of inhibit,to
R10331 T15673 T15670 arg2Of release,inhibit
R10332 T15673 T15671 arg1Of release,the
R10333 T15673 T15672 arg1Of release,spontaneous
R10334 T15673 T15674 arg1Of release,of
R10335 T15673 T15677 arg1Of release,by
R10336 T15676 T15674 arg2Of cytokines,of
R10337 T15676 T15675 arg1Of cytokines,inflammatory
R10338 T15681 T15677 arg2Of cells,by
R10339 T15681 T15678 arg1Of cells,human
R10340 T15681 T15679 arg1Of cells,RA
R10341 T15681 T15680 arg1Of cells,synovial
R10342 T15684 T15682 arg1Of function,This
R10343 T15684 T15683 arg1Of function,inhibitory
R10344 T15684 T15685 arg1Of function,of
R10345 T15684 T15687 arg1Of function,was
R10346 T15684 T15689 arg2Of function,confirmed
R10347 T15686 T15685 arg2Of SIGIRR,of
R10348 T15689 T15687 arg2Of confirmed,was
R10349 T15689 T15688 arg1Of confirmed,further
R10350 T15689 T15691 arg1Of confirmed,vivo
R10351 T15689 T15692 arg1Of confirmed,","
R10352 T15689 T15693 arg1Of confirmed,since
R10353 T15691 T15690 arg1Of vivo,in
R10354 T15695 T15694 arg1Of mice,SIGIRR-deficient
R10355 T15695 T15696 arg1Of mice,developed
R10356 T15696 T15693 arg2Of developed,since
R10357 T15696 T15712 arg1Of developed,[
R10358 T15699 T15698 arg1Of severe,more
R10359 T15700 T15697 arg1Of disease,a
R10360 T15700 T15699 arg1Of disease,severe
R10361 T15700 T15701 arg1Of disease,in
R10362 T15700 T15707 arg1Of disease,as
R10363 T15703 T15701 arg2Of arthritis,in
R10364 T15703 T15702 arg1Of arthritis,zymosan-induced
R10365 T15707 T15696 arg2Of as,developed
R10366 T15707 T15704 arg1Of as,","
R10367 T15707 T15705 arg1Of as,as
R10368 T15707 T15706 arg1Of as,well
R10369 T15711 T15707 arg2Of models,as
R10370 T15711 T15708 arg1Of models,collagen-induced
R10371 T15711 T15709 arg1Of models,arthritis
R10372 T15711 T15710 arg1Of models,mouse
R10373 T15713 T15712 arg2Of 70,[
R10374 T15714 T15712 arg3Of ],[
R10375 T15717 T15716 arg2Of be,will
R10376 T15718 T15717 arg2Of interesting,be
R10377 T15720 T15719 arg1Of compare,to
R10378 T15720 T15735 arg1Of compare,or
R10379 T15722 T15720 arg2Of expression,compare
R10380 T15722 T15721 arg1Of expression,the
R10381 T15722 T15723 arg1Of expression,of
R10382 T15722 T15725 arg1Of expression,in
R10383 T15724 T15723 arg2Of SIGIRR,of
R10384 T15727 T15725 arg2Of patients,in
R10385 T15727 T15726 arg1Of patients,RA
R10386 T15727 T15728 arg1Of patients,with
R10387 T15730 T15728 arg2Of expression,with
R10388 T15730 T15729 arg1Of expression,its
R10389 T15730 T15731 arg1Of expression,in
R10390 T15733 T15731 arg2Of patients,in
R10391 T15733 T15732 arg1Of patients,control
R10392 T15735 T15715 arg1Of or,It
R10393 T15735 T15716 arg1Of or,will
R10394 T15735 T15717 arg1Of or,be
R10395 T15735 T15718 arg1Of or,interesting
R10396 T15735 T15734 arg1Of or,","
R10397 T15737 T15735 arg2Of investigate,or
R10398 T15737 T15736 arg1Of investigate,to
R10399 T15740 T15739 arg1Of function,the
R10400 T15740 T15741 arg1Of function,of
R10401 T15740 T15743 arg1Of function,is
R10402 T15740 T15744 arg2Of function,compromised
R10403 T15742 T15741 arg2Of SIGIRR,of
R10404 T15744 T15737 arg2Of compromised,investigate
R10405 T15744 T15738 arg1Of compromised,whether
R10406 T15744 T15743 arg2Of compromised,is
R10407 T15744 T15745 arg1Of compromised,in
R10408 T15747 T15745 arg2Of patients,in
R10409 T15747 T15746 arg1Of patients,RA
R10410 T15748 T15749 arg1Of Because,of
R10411 T15753 T15748 arg2Of pattern,Because
R10412 T15753 T15750 arg1Of pattern,its
R10413 T15753 T15751 arg1Of pattern,restricted
R10414 T15753 T15752 arg1Of pattern,expression
R10415 T15755 T15756 arg1Of SIGIRR,may
R10416 T15755 T15758 arg1Of SIGIRR,be
R10417 T15758 T15748 arg1Of be,Because
R10418 T15758 T15754 arg1Of be,","
R10419 T15758 T15756 arg2Of be,may
R10420 T15758 T15757 arg1Of be,also
R10421 T15762 T15758 arg2Of target,be
R10422 T15762 T15759 arg1Of target,an
R10423 T15762 T15760 arg1Of target,interesting
R10424 T15762 T15761 arg1Of target,therapeutic
R10425 T15762 T15763 arg1Of target,in
R10426 T15764 T15763 arg2Of RA,in
R10780 T16432 T16430 arg1Of factor,TNF
R10781 T16432 T16431 arg1Of factor,receptor-associated
R10782 T16432 T16433 arg1Of factor,1
R10783 T16434 T16435 arg1Of TRAF1,is
R10784 T16435 T16444 arg1Of is,because
R10785 T16438 T16435 arg2Of member,is
R10786 T16438 T16436 arg1Of member,a
R10787 T16438 T16437 arg1Of member,unique
R10788 T16438 T16439 arg1Of member,of
R10789 T16443 T16439 arg2Of family,of
R10790 T16443 T16440 arg1Of family,the
R10791 T16443 T16441 arg1Of family,TRAF
R10792 T16443 T16442 arg1Of family,protein
R10793 T16445 T16446 arg1Of it,lacks
R10794 T16445 T16453 arg1Of it,lacks
R10795 T16446 T16451 arg1Of lacks,and
R10796 T16450 T16446 arg2Of domain,lacks
R10797 T16450 T16447 arg1Of domain,a
R10798 T16450 T16448 arg1Of domain,RING
R10799 T16450 T16449 arg1Of domain,finger
R10800 T16451 T16444 arg2Of and,because
R10801 T16453 T16451 arg2Of lacks,and
R10802 T16453 T16452 arg1Of lacks,therefore
R10803 T16456 T16453 arg2Of activity,lacks
R10804 T16456 T16454 arg1Of activity,ubiquitin
R10805 T16456 T16455 arg1Of activity,ligase
R10806 T16458 T16457 arg1Of data,Accumulating
R10807 T16458 T16459 arg1Of data,support
R10808 T16459 T16480 arg1Of support,","
R10809 T16459 T16482 arg1Of support,in
R10810 T16459 T16486 arg1Of support,[
R10811 T16461 T16459 arg2Of role,support
R10812 T16461 T16460 arg1Of role,a
R10813 T16461 T16462 arg1Of role,for
R10814 T16461 T16464 arg1Of role,as
R10815 T16461 T16475 arg1Of role,by
R10816 T16463 T16462 arg2Of TRAF1,for
R10817 T16467 T16468 arg1Of negative,and
R10818 T16470 T16468 arg2Of positive,and
R10819 T16470 T16469 arg1Of positive,a
R10820 T16471 T16464 arg2Of modulator,as
R10821 T16471 T16465 arg1Of modulator,both
R10822 T16471 T16466 arg1Of modulator,a
R10823 T16471 T16467 arg1Of modulator,negative
R10824 T16471 T16470 arg1Of modulator,positive
R10825 T16471 T16472 arg1Of modulator,of
R10826 T16474 T16472 arg2Of signalling,of
R10827 T16474 T16473 arg1Of signalling,NF-κB
R10828 T16479 T16475 arg2Of receptors,by
R10829 T16479 T16476 arg1Of receptors,certain
R10830 T16479 T16477 arg1Of receptors,TNF
R10831 T16479 T16478 arg1Of receptors,family
R10832 T16482 T16481 arg1Of in,possibly
R10833 T16485 T16482 arg2Of manner,in
R10834 T16485 T16483 arg1Of manner,a
R10835 T16485 T16484 arg1Of manner,cell-type-dependent
R10836 T16487 T16486 arg2Of "71,72",[
R10837 T16488 T16486 arg3Of ],[
R10838 T16489 T16490 arg1Of Expression,of
R10839 T16489 T16492 arg1Of Expression,is
R10840 T16489 T16493 arg1Of Expression,inducible
R10841 T16491 T16490 arg2Of TRAF1,of
R10842 T16492 T16496 arg1Of is,and
R10843 T16493 T16492 arg2Of inducible,is
R10844 T16493 T16494 arg1Of inducible,by
R10845 T16495 T16494 arg2Of TNF,by
R10846 T16497 T16498 arg1Of overexpression,of
R10847 T16497 T16500 arg1Of overexpression,inhibits
R10848 T16499 T16498 arg2Of TRAF1,of
R10849 T16500 T16496 arg2Of inhibits,and
R10850 T16503 T16500 arg2Of activation,inhibits
R10851 T16503 T16501 arg1Of activation,TNF-induced
R10852 T16503 T16502 arg1Of activation,NF-κB
R10853 T16506 T16504 arg1Of cells,TRAF1-deficient
R10854 T16506 T16505 arg1Of cells,T
R10855 T16506 T16507 arg1Of cells,are
R10856 T16506 T16508 arg1Of cells,hyper-responsive
R10857 T16507 T16511 arg1Of are,","
R10858 T16507 T16512 arg1Of are,with
R10859 T16508 T16507 arg2Of hyper-responsive,are
R10860 T16508 T16509 arg1Of hyper-responsive,to
R10861 T16510 T16509 arg2Of TNF,to
R10862 T16514 T16515 arg1Of proliferation,and
R10863 T16515 T16512 arg2Of and,with
R10864 T16515 T16513 arg2Of and,enhanced
R10865 T16515 T16517 arg1Of and,of
R10866 T16516 T16515 arg2Of activation,and
R10867 T16521 T16517 arg2Of pathway,of
R10868 T16521 T16518 arg1Of pathway,the
R10869 T16521 T16519 arg1Of pathway,NF-κB
R10870 T16521 T16520 arg1Of pathway,signalling
R10871 T16522 T16524 arg1Of TRAF1,functions
R10872 T16524 T16523 arg1Of functions,also
R10873 T16524 T16525 arg1Of functions,as
R10874 T16528 T16525 arg2Of regulator,as
R10875 T16528 T16526 arg1Of regulator,a
R10876 T16528 T16527 arg1Of regulator,negative
R10877 T16528 T16529 arg1Of regulator,of
R10878 T16532 T16529 arg2Of activation,of
R10879 T16532 T16530 arg1Of activation,CD40-induced
R10880 T16532 T16531 arg1Of activation,NF-κB
R10881 T16535 T16533 arg1Of cells,TRAF1-deficient
R10882 T16535 T16534 arg1Of cells,dendritic
R10883 T16535 T16539 arg1Of cells,show
R10884 T16539 T16536 arg1Of show,","
R10885 T16539 T16537 arg1Of show,however
R10886 T16539 T16538 arg1Of show,","
R10887 T16539 T16548 arg1Of show,","
R10888 T16539 T16549 modOf show,suggesting
R10889 T16541 T16539 arg2Of responses,show
R10890 T16541 T16540 arg2Of responses,attenuated
R10891 T16541 T16542 arg1Of responses,to
R10892 T16544 T16542 arg2Of stimulation,to
R10893 T16544 T16543 arg1Of stimulation,secondary
R10894 T16544 T16545 arg1Of stimulation,by
R10895 T16547 T16545 arg2Of factors,by
R10896 T16547 T16546 arg1Of factors,TRAF2-dependent
R10897 T16549 T16554 arg1Of suggesting,in
R10898 T16553 T16549 arg2Of role,suggesting
R10899 T16553 T16550 arg1Of role,a
R10900 T16553 T16551 arg1Of role,positive
R10901 T16553 T16552 arg1Of role,regulatory
R10902 T16556 T16554 arg2Of cells,in
R10903 T16556 T16555 arg1Of cells,these
R10904 T16558 T16557 arg1Of mechanism,The
R10905 T16558 T16559 arg2Of mechanism,by
R10906 T16558 T16560 arg1Of mechanism,which
R10907 T16558 T16566 arg1Of mechanism,is
R10908 T16558 T16568 arg1Of mechanism,unclear
R10909 T16561 T16562 arg1Of TRAF1,modulates
R10910 T16562 T16559 arg1Of modulates,by
R10911 T16565 T16562 arg2Of activation,modulates
R10912 T16565 T16563 arg1Of activation,NF-
R10913 T16565 T16564 arg1Of activation,κB
R10914 T16566 T16567 arg1Of is,still
R10915 T16568 T16566 arg2Of unclear,is
R10916 T16570 T16569 arg1Of probably,Most
R10917 T16572 T16573 arg1Of TRAF1,competes
R10918 T16573 T16570 arg1Of competes,probably
R10919 T16573 T16571 arg1Of competes,","
R10920 T16573 T16574 arg1Of competes,with
R10921 T16577 T16574 arg2Of members,with
R10922 T16577 T16575 arg1Of members,TRAF
R10923 T16577 T16576 arg1Of members,family
R10924 T16577 T16578 arg1Of members,for
R10925 T16579 T16578 arg2Of binding,for
R10926 T16579 T16580 arg1Of binding,to
R10927 T16586 T16580 arg2Of proteins,to
R10928 T16586 T16581 arg1Of proteins,the
R10929 T16586 T16582 arg1Of proteins,receptor
R10930 T16586 T16583 arg1Of proteins,or
R10931 T16586 T16584 arg1Of proteins,other
R10932 T16586 T16585 arg1Of proteins,signalling
R10933 T16589 T16590 arg1Of TRAF1,might
R10934 T16589 T16591 arg1Of TRAF1,recruit
R10935 T16591 T16587 arg1Of recruit,Alternatively
R10936 T16591 T16588 arg1Of recruit,","
R10937 T16591 T16590 arg2Of recruit,might
R10938 T16592 T16591 arg2Of A20,recruit
R10939 T16592 T16593 arg2Of A20,with
R10940 T16592 T16594 arg1Of A20,which
R10941 T16595 T16596 arg1Of it,can
R10942 T16595 T16598 arg1Of it,interact
R10943 T16598 T16593 arg1Of interact,with
R10944 T16598 T16596 arg2Of interact,can
R10945 T16598 T16597 arg1Of interact,physically
R10946 T16598 T16599 arg1Of interact,[
R10947 T16600 T16599 arg2Of 73,[
R10948 T16601 T16599 arg3Of ],[
R10949 T16605 T16602 arg1Of study,A
R10950 T16605 T16603 arg1Of study,genome-wide
R10951 T16605 T16604 arg1Of study,association
R10952 T16605 T16606 arg1Of study,examining
R10953 T16605 T16620 arg1Of study,identified
R10954 T16606 T16611 arg1Of examining,among
R10955 T16607 T16608 arg1Of more,than
R10956 T16609 T16608 arg2Of "300,000",than
R10957 T16610 T16606 arg2Of SNPs,examining
R10958 T16610 T16607 arg1Of SNPs,more
R10959 T16613 T16612 arg1Of "1,500",approximately
R10960 T16616 T16613 arg1Of cases,"1,500"
R10961 T16616 T16614 arg1Of cases,autoantibody-positive
R10962 T16616 T16615 arg1Of cases,RA
R10963 T16616 T16617 arg1Of cases,and
R10964 T16617 T16611 arg2Of and,among
R10965 T16619 T16617 arg2Of controls,and
R10966 T16619 T16618 arg1Of controls,"1,800"
R10967 T16620 T16630 arg1Of identified,as
R10968 T16620 T16636 arg1Of identified,[
R10969 T16623 T16620 arg2Of variation,identified
R10970 T16623 T16621 arg1Of variation,a
R10971 T16623 T16622 arg1Of variation,genetic
R10972 T16623 T16624 arg1Of variation,at
R10973 T16629 T16624 arg2Of locus,at
R10974 T16629 T16625 arg1Of locus,the
R10975 T16629 T16626 arg1Of locus,TRAF1-complement
R10976 T16629 T16627 arg1Of locus,component
R10977 T16629 T16628 arg1Of locus,5
R10978 T16635 T16630 arg2Of locus,as
R10979 T16635 T16631 arg1Of locus,an
R10980 T16635 T16632 arg1Of locus,important
R10981 T16635 T16633 arg1Of locus,RA
R10982 T16635 T16634 arg1Of locus,risk
R10983 T16637 T16636 arg2Of 74,[
R10984 T16638 T16636 arg3Of ],[
R10985 T16640 T16639 arg1Of work,Subsequent
R10986 T16640 T16641 arg1Of work,indicates
R10987 T16643 T16644 arg1Of TRAF1,is
R10988 T16643 T16646 arg1Of TRAF1,likely
R10989 T16643 T16648 arg1Of TRAF1,be
R10990 T16644 T16641 arg2Of is,indicates
R10991 T16644 T16642 arg1Of is,that
R10992 T16644 T16652 arg1Of is,[
R10993 T16646 T16644 arg2Of likely,is
R10994 T16646 T16645 arg1Of likely,more
R10995 T16648 T16646 arg2Of be,likely
R10996 T16648 T16647 arg1Of be,to
R10997 T16651 T16648 arg2Of locus,be
R10998 T16651 T16649 arg1Of locus,the
R10999 T16651 T16650 arg1Of locus,causative
R11 T18 T16 arg1Of NF-κB,transcription
R11000 T16653 T16652 arg2Of 75,[
R11001 T16654 T16652 arg3Of ],[
R11002 T16656 T16655 arg1Of work,Recent
R11003 T16656 T16657 arg1Of work,in
R11004 T16656 T16662 arg1Of work,demonstrates
R11005 T16660 T16657 arg2Of population,in
R11006 T16660 T16658 arg1Of population,a
R11007 T16660 T16659 arg1Of population,Korean
R11008 T16662 T16661 arg1Of demonstrates,also
R11009 T16664 T16662 arg2Of association,demonstrates
R11010 T16664 T16663 arg1Of association,genetic
R11011 T16664 T16665 arg1Of association,of
R11012 T16668 T16665 arg2Of region,of
R11013 T16668 T16666 arg1Of region,the
R11014 T16668 T16667 arg1Of region,TRAF1
R11015 T16668 T16669 arg1Of region,with
R11016 T16670 T16669 arg2Of RA,with
R11017 T16670 T16671 arg1Of RA,[
R11018 T16672 T16671 arg2Of 76,[
R11019 T16673 T16671 arg3Of ],[
R11440 T17544 T17545 arg1Of miRNAs,are
R11441 T17544 T17553 arg1Of miRNAs,represent
R11442 T17545 T17552 arg1Of are,and
R11443 T17547 T17546 arg1Of discovered,recently
R11444 T17548 T17545 arg2Of regulators,are
R11445 T17548 T17547 arg1Of regulators,discovered
R11446 T17548 T17549 arg1Of regulators,of
R11447 T17551 T17549 arg2Of expression,of
R11448 T17551 T17550 arg1Of expression,gene
R11449 T17553 T17552 arg2Of represent,and
R11450 T17555 T17553 arg2Of class,represent
R11451 T17555 T17554 arg1Of class,a
R11452 T17555 T17556 arg1Of class,of
R11453 T17559 T17556 arg2Of molecules,of
R11454 T17559 T17557 arg1Of molecules,noncoding
R11455 T17559 T17558 arg1Of molecules,RNA
R11456 T17559 T17560 arg1Of molecules,essential
R11457 T17560 T17561 arg1Of essential,in
R11458 T17563 T17564 arg1Of cellular,and
R11459 T17565 T17564 arg2Of developmental,and
R11460 T17566 T17561 arg2Of processes,in
R11461 T17566 T17562 arg1Of processes,many
R11462 T17566 T17563 arg1Of processes,cellular
R11463 T17566 T17565 arg1Of processes,developmental
R11464 T17566 T17567 arg1Of processes,","
R11465 T17566 T17568 arg1Of processes,including
R11466 T17570 T17569 arg1Of responses,immune
R11467 T17570 T17571 arg1Of responses,and
R11468 T17571 T17568 arg2Of and,including
R11469 T17572 T17571 arg2Of inflammation,and
R11470 T17573 T17574 arg1Of They,bind
R11471 T17576 T17574 arg2Of 3'-UTR,bind
R11472 T17576 T17575 arg1Of 3'-UTR,the
R11473 T17576 T17577 arg1Of 3'-UTR,of
R11474 T17579 T17577 arg2Of mRNAs,of
R11475 T17579 T17578 arg1Of mRNAs,target
R11476 T17579 T17580 arg1Of mRNAs,leading
R11477 T17580 T17581 arg1Of leading,to
R11478 T17583 T17582 arg1Of repression,the
R11479 T17583 T17584 arg1Of repression,of
R11480 T17583 T17587 arg1Of repression,and
R11481 T17586 T17584 arg2Of expression,of
R11482 T17586 T17585 arg1Of expression,protein
R11483 T17587 T17581 arg2Of and,to
R11484 T17589 T17587 arg2Of promotion,and
R11485 T17589 T17588 arg1Of promotion,the
R11486 T17589 T17590 arg1Of promotion,of
R11487 T17593 T17590 arg2Of degradation,of
R11488 T17593 T17591 arg1Of degradation,target
R11489 T17593 T17592 arg1Of degradation,mRNA
R11490 T17593 T17594 arg1Of degradation,[
R11491 T17595 T17594 arg2Of 77,[
R11492 T17596 T17594 arg3Of ],[
R11493 T17597 T17598 arg1Of miR-146a/b,and
R11494 T17598 T17600 arg1Of and,are
R11495 T17598 T17601 arg1Of and,of
R11496 T17599 T17598 arg2Of miR-155,and
R11497 T17600 T17609 arg1Of are,","
R11498 T17600 T17610 arg1Of are,since
R11499 T17601 T17600 arg2Of of,are
R11500 T17603 T17601 arg2Of interest,of
R11501 T17603 T17602 arg1Of interest,particular
R11502 T17603 T17604 arg1Of interest,for
R11503 T17606 T17604 arg2Of signalling,for
R11504 T17606 T17605 arg1Of signalling,inflammatory
R11505 T17606 T17607 arg1Of signalling,to
R11506 T17608 T17607 arg2Of NF-κB,to
R11507 T17612 T17611 arg1Of miRNAs,these
R11508 T17612 T17613 arg1Of miRNAs,can
R11509 T17612 T17614 arg1Of miRNAs,be
R11510 T17612 T17615 arg2Of miRNAs,induced
R11511 T17615 T17610 arg2Of induced,since
R11512 T17615 T17613 arg2Of induced,can
R11513 T17615 T17614 arg2Of induced,be
R11514 T17618 T17615 arg1Of stimuli,induced
R11515 T17618 T17616 arg2Of stimuli,by
R11516 T17618 T17617 arg1Of stimuli,inflammatory
R11517 T17618 T17620 arg1Of stimuli,as
R11518 T17620 T17619 arg1Of as,such
R11519 T17621 T17622 arg1Of IL-1β,","
R11520 T17622 T17624 arg1Of ",",and
R11521 T17623 T17622 arg2Of TNF,","
R11522 T17624 T17620 arg2Of and,as
R11523 T17625 T17624 arg2Of TLRs,and
R11524 T17625 T17626 arg1Of TLRs,[
R11525 T17627 T17626 arg2Of "78,79",[
R11526 T17628 T17626 arg3Of ],[
R11527 T17630 T17629 arg2Of addition,In
R11528 T17632 T17633 arg1Of miR-146a,is
R11529 T17633 T17629 arg1Of is,In
R11530 T17633 T17631 arg1Of is,","
R11531 T17633 T17638 arg1Of is,and
R11532 T17636 T17633 arg2Of gene,is
R11533 T17636 T17634 arg1Of gene,an
R11534 T17636 T17635 arg1Of gene,NF-κB-dependent
R11535 T17638 T17637 arg1Of and,","
R11536 T17643 T17644 arg1Of IRAK1,and
R11537 T17644 T17639 arg1Of and,the
R11538 T17644 T17640 arg1Of and,NF-κB
R11539 T17644 T17641 arg1Of and,signalling
R11540 T17644 T17642 arg1Of and,molecules
R11541 T17644 T17646 arg1Of and,were
R11542 T17644 T17647 arg2Of and,identified
R11543 T17645 T17644 arg2Of TRAF6,and
R11544 T17647 T17638 arg2Of identified,and
R11545 T17647 T17646 arg2Of identified,were
R11546 T17647 T17648 arg1Of identified,as
R11547 T17647 T17653 arg1Of identified,[
R11548 T17647 T17656 arg1Of identified,(
R11549 T17650 T17648 arg2Of genes,as
R11550 T17650 T17649 arg1Of genes,target
R11551 T17650 T17651 arg1Of genes,of
R11552 T17652 T17651 arg2Of miR-146a,of
R11553 T17654 T17653 arg2Of 78,[
R11554 T17655 T17653 arg3Of ],[
R11555 T17657 T17656 arg2Of Figure,(
R11556 T17657 T17658 arg1Of Figure,1
R11557 T17659 T17656 arg3Of ),(
R11558 T17662 T17663 arg1Of miR-155,was
R11559 T17662 T17664 arg2Of miR-155,shown
R11560 T17664 T17660 arg1Of shown,Similarly
R11561 T17664 T17661 arg1Of shown,","
R11562 T17664 T17663 arg2Of shown,was
R11563 T17664 T17665 arg1Of shown,to
R11564 T17664 T17668 arg1Of shown,for
R11565 T17667 T17665 arg2Of transcripts,to
R11566 T17667 T17666 arg1Of transcripts,target
R11567 T17673 T17669 arg1Of IKKε,the
R11568 T17673 T17670 arg1Of IKKε,NF-κB
R11569 T17673 T17671 arg1Of IKKε,signalling
R11570 T17673 T17672 arg1Of IKKε,molecules
R11571 T17673 T17674 arg1Of IKKε,and
R11572 T17674 T17668 arg2Of and,for
R11573 T17675 T17674 arg2Of RIP1,and
R11574 T17675 T17676 arg1Of RIP1,[
R11575 T17677 T17676 arg2Of "79,80",[
R11576 T17678 T17676 arg3Of ],[
R11577 T17682 T17683 arg1Of miR-146,and
R11578 T17683 T17681 arg1Of and,both
R11579 T17683 T17685 arg1Of and,are
R11580 T17683 T17686 arg2Of and,expressed
R11581 T17684 T17683 arg2Of miR-155,and
R11582 T17686 T17685 arg2Of expressed,are
R11583 T17686 T17687 arg1Of expressed,at
R11584 T17686 T17704 arg1Of expressed,in
R11585 T17686 T17712 arg1Of expressed,[
R11586 T17687 T17703 arg1Of at,as
R11587 T17689 T17687 arg2Of levels,at
R11588 T17689 T17688 arg1Of levels,higher
R11589 T17689 T17690 arg1Of levels,in
R11590 T17693 T17691 arg1Of fibroblasts,RA
R11591 T17693 T17692 arg1Of fibroblasts,synovial
R11592 T17693 T17694 arg1Of fibroblasts,and
R11593 T17694 T17690 arg2Of and,in
R11594 T17696 T17694 arg2Of tissue,and
R11595 T17696 T17695 arg1Of tissue,synovial
R11596 T17696 T17697 arg1Of tissue,[
R11597 T17698 T17697 arg2Of "81,82",[
R11598 T17699 T17697 arg3Of ],[
R11599 T17703 T17700 arg1Of as,","
R11600 T17703 T17701 arg1Of as,as
R11601 T17703 T17702 arg1Of as,well
R11602 T17704 T17703 arg2Of in,as
R11603 T17708 T17704 arg2Of cells,in
R11604 T17708 T17705 arg1Of cells,peripheral
R11605 T17708 T17706 arg1Of cells,blood
R11606 T17708 T17707 arg1Of cells,mononuclear
R11607 T17708 T17709 arg1Of cells,of
R11608 T17711 T17709 arg2Of patients,of
R11609 T17711 T17710 arg1Of patients,RA
R11610 T17713 T17712 arg2Of 83,[
R11611 T17714 T17712 arg3Of ],[
R11612 T17715 T17716 arg1Of . miR-14,6a
R11613 T17715 T17718 arg2Of . miR-14,lso overexpre
R11614 T17718 T17679 arg1Of lso overexpre,Notably
R11615 T17718 T17680 arg1Of lso overexpre,","
R11616 T17718 T17685 modOf lso overexpre,are
R11617 T17718 T17716 arg2Of lso overexpre,6a
R11618 T17718 T17717 arg1Of lso overexpre,is a
R11619 T17718 T17719 arg1Of lso overexpre,ss
R11620 T17720 T17721 arg1Of ed i,n C
R11621 T17722 T17721 arg2Of D4+ and IL-17-p,n C
R11622 T17724 T17719 arg2Of oduci,ss
R11623 T17724 T17720 arg1Of oduci,ed i
R11624 T17724 T17722 arg1Of oduci,D4+ and IL-17-p
R11625 T17724 T17723 arg1Of oduci,r
R11626 T17724 T17725 arg1Of oduci,ng T
R11627 T17727 T17725 arg2Of lls from,ng T
R11628 T17727 T17726 arg1Of lls from,ce
R11629 T17727 T17728 arg1Of lls from,R
R11630 T17729 T17728 arg2Of A pat,R
R11631 T17730 T17728 arg3Of i,R
R11632 T17734 T17733 arg1Of polymorphism,a
R11633 T17734 T17735 arg1Of polymorphism,in
R11634 T17734 T17743 arg1Of polymorphism,was
R11635 T17734 T17745 arg2Of polymorphism,shown
R11636 T17734 T17747 arg1Of polymorphism,be
R11637 T17734 T17748 arg2Of polymorphism,associated
R11638 T17737 T17735 arg2Of 3'-UTR,in
R11639 T17737 T17736 arg1Of 3'-UTR,the
R11640 T17737 T17738 arg1Of 3'-UTR,of
R11641 T17742 T17738 arg2Of gene,of
R11642 T17742 T17739 arg1Of gene,the
R11643 T17742 T17740 arg1Of gene,miR-146a
R11644 T17742 T17741 arg1Of gene,target
R11645 T17745 T17731 arg1Of shown,Interestingly
R11646 T17745 T17732 arg1Of shown,","
R11647 T17745 T17743 arg2Of shown,was
R11648 T17745 T17744 arg1Of shown,recently
R11649 T17748 T17745 arg3Of associated,shown
R11650 T17748 T17746 arg1Of associated,to
R11651 T17748 T17747 arg2Of associated,be
R11652 T17748 T17749 arg1Of associated,with
R11653 T17748 T17757 arg1Of associated,io
R11654 T17753 T17752 arg2Of 86,[
R11655 T17754 T17752 arg3Of ],[
R11656 T17756 T17749 arg2Of 55 overexpress,with
R11657 T17756 T17750 arg1Of 55 overexpress,RA
R11658 T17756 T17751 arg1Of 55 overexpress,susceptibility
R11659 T17756 T17752 arg1Of 55 overexpress,[
R11660 T17756 T17755 arg1Of 55 overexpress,. miR-1
R11661 T17759 T17758 arg1Of ovial fibro,n in syn
R11662 T17759 T17760 arg1Of ovial fibro,bla
R11663 T17759 T17761 arg1Of ovial fibro,sts
R11664 T17759 T17763 arg1Of ovial fibro,s able
R11665 T17760 T17757 arg2Of bla,io
R11666 T17761 T17760 arg2Of sts ,bla
R11667 T17763 T17761 arg2Of s able ,sts
R11668 T17763 T17762 arg1Of s able ,wa
R11669 T17765 T17766 arg1Of pre,ven
R11670 T17767 T17766 arg2Of t the TLR and cyto,ven
R11671 T17768 T17763 arg2Of kine-induc,s able
R11672 T17768 T17764 arg1Of kine-induc,to
R11673 T17768 T17765 arg1Of kine-induc,pre
R11674 T17768 T17767 arg1Of kine-induc,t the TLR and cyto
R11675 T17768 T17769 arg1Of kine-induc,ib
R11676 T17772 T17769 arg2Of of specific matrix,ib
R11677 T17772 T17770 arg1Of of specific matrix,le expre
R11678 T17772 T17771 arg1Of of specific matrix,ssion
R11679 T17772 T17773 arg1Of of specific matrix,meta
R11680 T17772 T17774 arg1Of of specific matrix,lloprot
R11681 T17774 T17777 arg1Of lloprot,at
R11682 T17774 T17779 arg1Of lloprot,t
R11683 T17776 T17774 arg2Of s that medi,lloprot
R11684 T17776 T17775 arg1Of s that medi,einase
R11685 T17778 T17777 arg2Of e ,at
R11686 T17780 T17779 arg2Of is,t
R11687 T17781 T17779 arg3Of s,t
R11688 T17784 T17785 arg1Of miR-155,was
R11689 T17784 T17786 arg2Of miR-155,shown
R11690 T17784 T17788 arg1Of miR-155,promote
R11691 T17786 T17785 arg2Of shown,was
R11692 T17786 T17804 arg1Of shown,46
R11693 T17788 T17786 arg3Of promote,shown
R11694 T17788 T17787 arg1Of promote,to
R11695 T17788 T17795 arg1Of promote,in
R11696 T17790 T17788 arg2Of production,promote
R11697 T17790 T17789 arg1Of production,TNF
R11698 T17790 T17791 arg1Of production,","
R11699 T17794 T17791 arg2Of process,","
R11700 T17794 T17792 arg1Of process,a
R11701 T17794 T17793 arg1Of process,key
R11702 T17797 T17795 arg2Of pathogenesis,in
R11703 T17797 T17796 arg1Of pathogenesis,the
R11704 T17797 T17798 arg1Of pathogenesis,of
R11705 T17799 T17798 arg2Of RA,of
R11706 T17801 T17800 arg2Of 87,[
R11707 T17802 T17800 arg3Of ],[
R11708 T17803 T17795 arg3Of . miR-1,in
R11709 T17803 T17800 arg1Of . miR-1,[
R11710 T17804 T17816 arg1Of 46 ,mma
R11711 T17805 T17806 arg1Of and miR,-15
R11712 T17805 T17808 arg1Of and miR,re
R11713 T17808 T17804 arg2Of re,46
R11714 T17808 T17806 arg2Of re,-15
R11715 T17808 T17807 arg1Of re,5 may the
R11716 T17810 T17809 arg1Of mportant,fore be i
R11717 T17811 T17808 arg2Of negative r,re
R11718 T17811 T17810 arg1Of negative r,mportant
R11719 T17811 T17812 arg1Of negative r,eg
R11720 T17811 T17814 arg1Of negative r,nf
R11721 T17813 T17812 arg2Of ulators of i,eg
R11722 T17815 T17814 arg2Of la,nf
R11723 T17816 T17782 arg1Of mma,Moreover
R11724 T17816 T17783 arg1Of mma,","
R11725 T17818 T17817 arg1Of in RA and,tion
R11726 T17818 T17819 arg1Of in RA and,the
R11727 T17818 T17825 arg1Of in RA and,t
R11728 T17818 T17826 arg1Of in RA and,of new trea
R11729 T17821 T17819 arg2Of potential f,the
R11730 T17821 T17820 arg1Of potential f,ir
R11731 T17821 T17822 arg1Of potential f,or
R11732 T17824 T17822 arg2Of developmen,or
R11733 T17824 T17823 arg1Of developmen,the
R11734 T17825 T17816 arg2Of t ,mma
R11735 T17826 T17825 arg2Of of new trea,t
R11736 T17828 T17827 arg2Of addition,In
R11737 T17832 T17830 arg1Of expression,their
R11738 T17832 T17831 arg2Of expression,increased
R11739 T17832 T17833 arg1Of expression,in
R11740 T17832 T17836 arg1Of expression,is
R11741 T17832 T17838 arg1Of expression,useful
R11742 T17835 T17833 arg2Of patients,in
R11743 T17835 T17834 arg1Of patients,RA
R11744 T17836 T17851 arg1Of is,[
R11745 T17836 T17855 arg1Of is,but
R11746 T17838 T17836 arg2Of useful,is
R11747 T17838 T17837 arg1Of useful,potentially
R11748 T17838 T17839 arg1Of useful,as
R11749 T17841 T17839 arg2Of marker,as
R11750 T17841 T17840 arg1Of marker,a
R11751 T17841 T17842 arg1Of marker,for
R11752 T17844 T17843 arg1Of diagnosis,disease
R11753 T17844 T17845 arg1Of diagnosis,","
R11754 T17845 T17848 arg1Of ",",or
R11755 T17846 T17845 arg2Of progression,","
R11756 T17848 T17842 arg2Of or,for
R11757 T17848 T17847 arg1Of or,","
R11758 T17850 T17848 arg2Of efficacy,or
R11759 T17850 T17849 arg1Of efficacy,treatment
R11760 T17852 T17851 arg2Of 88,[
R11761 T17853 T17851 arg3Of ],[
R11762 T17855 T17827 arg1Of but,In
R11763 T17855 T17829 arg1Of but,","
R11764 T17855 T17854 arg1Of but,","
R11765 T17856 T17857 arg1Of this,will
R11766 T17856 T17858 arg1Of this,require
R11767 T17856 T17860 arg1Of this,using
R11768 T17858 T17855 arg2Of require,but
R11769 T17858 T17857 arg2Of require,will
R11770 T17858 T17860 modOf require,using
R11771 T17859 T17858 arg2Of confirmation,require
R11772 T17862 T17863 arg1Of large,and
R11773 T17864 T17863 arg2Of well-defined,and
R11774 T17865 T17860 arg2Of cohort,using
R11775 T17865 T17861 arg1Of cohort,a
R11776 T17865 T17862 arg1Of cohort,large
R11777 T17865 T17864 arg1Of cohort,well-defined
R11778 T17867 T17868 arg1Of miR-146,and
R11779 T17868 T17866 arg2Of and,Besides
R11780 T17869 T17868 arg2Of miR-155,and
R11781 T17872 T17871 arg1Of number,a
R11782 T17872 T17873 arg1Of number,of
R11783 T17872 T17876 arg1Of number,with
R11784 T17872 T17890 arg1Of number,were
R11785 T17872 T17892 arg2Of number,identified
R11786 T17875 T17873 arg2Of miRNAs,of
R11787 T17875 T17874 arg1Of miRNAs,other
R11788 T17879 T17876 arg2Of role,with
R11789 T17879 T17877 arg1Of role,a
R11790 T17879 T17878 arg1Of role,potential
R11791 T17879 T17880 arg1Of role,in
R11792 T17879 T17887 arg1Of role,in
R11793 T17882 T17880 arg2Of control,in
R11794 T17882 T17881 arg1Of control,the
R11795 T17882 T17883 arg1Of control,of
R11796 T17886 T17883 arg2Of responses,of
R11797 T17886 T17884 arg1Of responses,NF-κB-dependent
R11798 T17886 T17885 arg1Of responses,inflammatory
R11799 T17889 T17887 arg2Of pathology,in
R11800 T17889 T17888 arg1Of pathology,RA
R11801 T17892 T17866 arg1Of identified,Besides
R11802 T17892 T17870 arg1Of identified,","
R11803 T17892 T17890 arg2Of identified,were
R11804 T17892 T17891 arg1Of identified,recently
R11805 T17895 T17893 arg2Of context,In
R11806 T17895 T17894 arg1Of context,this
R11807 T17897 T17898 arg1Of miR-124a,-
R11808 T17897 T17910 arg1Of miR-124a,was
R11809 T17897 T17911 arg2Of miR-124a,shown
R11810 T17897 T17913 arg1Of miR-124a,be
R11811 T17897 T17914 arg2Of miR-124a,decreased
R11812 T17901 T17898 arg2Of regulator,-
R11813 T17901 T17899 arg1Of regulator,a
R11814 T17901 T17900 arg1Of regulator,key
R11815 T17901 T17902 arg1Of regulator,of
R11816 T17907 T17902 arg2Of protein,of
R11817 T17907 T17903 arg1Of protein,the
R11818 T17907 T17904 arg1Of protein,chemokine
R11819 T17907 T17905 arg1Of protein,monocyte
R11820 T17907 T17906 arg1Of protein,chemoattractant
R11821 T17907 T17908 arg1Of protein,1
R11822 T17909 T17898 arg3Of -,-
R11823 T17911 T17893 arg1Of shown,In
R11824 T17911 T17896 arg1Of shown,","
R11825 T17911 T17910 arg2Of shown,was
R11826 T17914 T17911 arg3Of decreased,shown
R11827 T17914 T17912 arg1Of decreased,to
R11828 T17914 T17913 arg2Of decreased,be
R11829 T17914 T17915 arg1Of decreased,in
R11830 T17916 T17915 arg2Of synoviocytes,in
R11831 T17916 T17917 arg1Of synoviocytes,from
R11832 T17919 T17917 arg2Of patients,from
R11833 T17919 T17918 arg1Of patients,RA
R11834 T17919 T17920 arg1Of patients,[
R11835 T17921 T17920 arg2Of 89,[
R11836 T17922 T17920 arg3Of ],[
R11837 T17926 T17925 arg1Of levels,elevated
R11838 T17926 T17927 arg1Of levels,of
R11839 T17926 T17929 arg1Of levels,-
R11840 T17926 T17930 arg1Of levels,leading
R11841 T17926 T17939 arg1Of levels,-
R11842 T17926 T17940 arg1Of levels,were
R11843 T17926 T17941 arg2Of levels,detected
R11844 T17928 T17927 arg2Of miR-203,of
R11845 T17930 T17931 arg1Of leading,to
R11846 T17933 T17931 arg2Of secretion,to
R11847 T17933 T17932 arg2Of secretion,increased
R11848 T17933 T17934 arg1Of secretion,of
R11849 T17936 T17935 arg1Of metalloproteinase-1,matrix
R11850 T17936 T17937 arg1Of metalloproteinase-1,and
R11851 T17937 T17934 arg2Of and,of
R11852 T17938 T17937 arg2Of IL-6,and
R11853 T17941 T17923 arg1Of detected,Similarly
R11854 T17941 T17924 arg1Of detected,","
R11855 T17941 T17940 arg2Of detected,were
R11856 T17941 T17942 arg1Of detected,in
R11857 T17941 T17946 arg1Of detected,[
R11858 T17945 T17942 arg2Of fibroblasts,in
R11859 T17945 T17943 arg1Of fibroblasts,RA
R11860 T17945 T17944 arg1Of fibroblasts,synovial
R11861 T17947 T17946 arg2Of 90,[
R11862 T17948 T17946 arg3Of ],[
R11863 T17951 T17952 arg1Of miR-16,","
R11864 T17952 T17955 arg1Of ",",and
R11865 T17953 T17952 arg2Of miR-132,","
R11866 T17955 T17954 arg1Of and,","
R11867 T17955 T17957 arg1Of and,were
R11868 T17955 T17959 arg2Of and,shown
R11869 T17955 T17961 arg1Of and,have
R11870 T17956 T17955 arg2Of miR-223,and
R11871 T17959 T17949 arg1Of shown,Finally
R11872 T17959 T17950 arg1Of shown,","
R11873 T17959 T17957 arg2Of shown,were
R11874 T17959 T17958 arg1Of shown,also
R11875 T17959 T17968 arg1Of shown,","
R11876 T17959 T17969 modOf shown,indicating
R11877 T17961 T17959 arg3Of have,shown
R11878 T17961 T17960 arg1Of have,to
R11879 T17964 T17961 arg2Of expression,have
R11880 T17964 T17962 arg1Of expression,an
R11881 T17964 T17963 arg2Of expression,altered
R11882 T17964 T17965 arg1Of expression,in
R11883 T17967 T17965 arg2Of patients,in
R11884 T17967 T17966 arg1Of patients,RA
R11885 T17971 T17969 arg2Of potential,indicating
R11886 T17971 T17970 arg1Of potential,their
R11887 T17971 T17972 arg1Of potential,as
R11888 T17974 T17972 arg2Of biomarkers,as
R11889 T17974 T17973 arg1Of biomarkers,diagnostic
R11890 T17974 T17975 arg1Of biomarkers,for
R11891 T17976 T17975 arg2Of pathogenesis,for
R11892 T17976 T17977 arg1Of pathogenesis,[
R11893 T17978 T17977 arg2Of "83,88,91",[
R11894 T17979 T17977 arg3Of ],[
R12 T18 T17 arg1Of NF-κB,factor
R12465 T18905 T18903 arg1Of family,The
R12466 T18905 T18904 arg1Of family,NF-κB
R12467 T18905 T18906 arg1Of family,of
R12468 T18905 T18909 arg1Of family,plays
R12469 T18908 T18906 arg2Of factors,of
R12470 T18908 T18907 arg1Of factors,transcription
R12471 T18909 T18912 arg1Of plays,in
R12472 T18911 T18909 arg2Of roles,plays
R12473 T18911 T18910 arg1Of roles,crucial
R12474 T18915 T18912 arg2Of processes,in
R12475 T18915 T18913 arg1Of processes,the
R12476 T18915 T18914 arg1Of processes,inflammatory
R12477 T18915 T18916 arg1Of processes,in
R12478 T18915 T18918 arg1Of processes,leading
R12479 T18917 T18916 arg2Of RA,in
R12480 T18918 T18919 arg1Of leading,to
R12481 T18920 T18921 arg1Of cartilage,and
R12482 T18922 T18921 arg2Of bone,and
R12483 T18923 T18919 arg2Of destruction,to
R12484 T18923 T18920 arg1Of destruction,cartilage
R12485 T18923 T18922 arg1Of destruction,bone
R12486 T18926 T18924 arg1Of activation,Keeping
R12487 T18926 T18925 arg1Of activation,NF-κB
R12488 T18926 T18927 arg1Of activation,under
R12489 T18926 T18929 arg1Of activation,can
R12490 T18926 T18931 arg1Of activation,be
R12491 T18926 T18933 arg1Of activation,important
R12492 T18928 T18927 arg2Of control,under
R12493 T18931 T18929 arg2Of be,can
R12494 T18931 T18930 arg1Of be,thus
R12495 T18933 T18931 arg2Of important,be
R12496 T18933 T18932 arg1Of important,very
R12497 T18933 T18934 arg1Of important,for
R12498 T18936 T18934 arg2Of design,for
R12499 T18936 T18935 arg1Of design,the
R12500 T18936 T18937 arg1Of design,of
R12501 T18939 T18937 arg2Of therapeutics,of
R12502 T18939 T18938 arg1Of therapeutics,specific
R12503 T18941 T18940 arg1Of existence,The
R12504 T18941 T18942 arg1Of existence,of
R12505 T18941 T18957 arg1Of existence,raises
R12506 T18945 T18942 arg2Of regulators,of
R12507 T18945 T18943 arg1Of regulators,multiple
R12508 T18945 T18944 arg1Of regulators,negative
R12509 T18945 T18946 arg1Of regulators,ensuring
R12510 T18949 T18946 arg2Of regulation,ensuring
R12511 T18949 T18947 arg1Of regulation,a
R12512 T18949 T18948 arg1Of regulation,tight
R12513 T18949 T18950 arg1Of regulation,of
R12514 T18953 T18950 arg2Of pathway,of
R12515 T18953 T18951 arg1Of pathway,the
R12516 T18953 T18952 arg1Of pathway,NF-κB
R12517 T18957 T18954 arg1Of raises,","
R12518 T18957 T18955 arg1Of raises,however
R12519 T18957 T18956 arg1Of raises,","
R12520 T18959 T18958 arg1Of question,the
R12521 T18959 T18960 arg1Of question,of
R12522 T18959 T18969 arg1Of question,and
R12523 T18963 T18960 arg2Of role,of
R12524 T18963 T18961 arg1Of role,the
R12525 T18963 T18962 arg1Of role,specific
R12526 T18963 T18964 arg1Of role,of
R12527 T18965 T18964 arg2Of each,of
R12528 T18965 T18966 arg1Of each,of
R12529 T18968 T18966 arg2Of regulators,of
R12530 T18968 T18967 arg1Of regulators,these
R12531 T18969 T18957 arg2Of and,raises
R12532 T18971 T18969 arg2Of relationship,and
R12533 T18971 T18970 arg1Of relationship,the
R12534 T18971 T18972 arg1Of relationship,between
R12535 T18973 T18972 arg2Of them,between
R12536 T18975 T18974 arg2Of addition,In
R12537 T18979 T18977 arg2Of number,given
R12538 T18979 T18978 arg1Of number,the
R12539 T18979 T18980 arg1Of number,of
R12540 T18979 T18982 arg1Of number,in
R12541 T18981 T18980 arg2Of miRNAs,of
R12542 T18983 T18984 arg1Of humans,and
R12543 T18984 T18982 arg2Of and,in
R12544 T18987 T18984 arg2Of mRNAs,and
R12545 T18987 T18985 arg1Of mRNAs,the
R12546 T18987 T18986 arg1Of mRNAs,multiple
R12547 T18987 T18989 arg2Of mRNAs,target
R12548 T18988 T18989 arg1Of they,target
R12549 T18992 T18991 arg1Of complexity,intense
R12550 T18992 T18993 arg1Of complexity,can
R12551 T18992 T18994 arg1Of complexity,be
R12552 T18992 T18995 arg2Of complexity,expected
R12553 T18995 T18974 arg1Of expected,In
R12554 T18995 T18976 arg1Of expected,","
R12555 T18995 T18977 arg1Of expected,given
R12556 T18995 T18990 arg1Of expected,","
R12557 T18995 T18993 arg2Of expected,can
R12558 T18995 T18994 arg2Of expected,be
R12559 T18996 T19004 arg1Of How,will
R12560 T18996 T19005 arg1Of How,be
R12561 T18996 T19012 arg1Of How,clarify
R12562 T19000 T18997 arg1Of signals,all
R12563 T19000 T18998 arg1Of signals,these
R12564 T19000 T18999 arg1Of signals,regulatory
R12565 T19000 T19001 arg1Of signals,are
R12566 T19001 T18996 arg1Of are,How
R12567 T19002 T19003 arg1Of themselves,regulated
R12568 T19005 T19003 arg2Of be,regulated
R12569 T19005 T19004 arg2Of be,will
R12570 T19005 T19009 arg1Of be,in
R12571 T19008 T19005 arg2Of question,be
R12572 T19008 T19006 arg1Of question,an
R12573 T19008 T19007 arg1Of question,important
R12574 T19010 T19009 arg2Of order,in
R12575 T19012 T19009 arg3Of clarify,in
R12576 T19012 T19011 arg1Of clarify,to
R12577 T19012 T19018 arg1Of clarify,","
R12578 T19012 T19019 arg1Of clarify,and
R12579 T19012 T19020 arg1Of clarify,","
R12580 T19012 T19022 arg1Of clarify,importantly
R12581 T19012 T19023 arg1Of clarify,","
R12582 T19013 T19012 arg2Of how,clarify
R12583 T19015 T19014 arg1Of signalling,NF-κB
R12584 T19015 T19016 arg1Of signalling,is
R12585 T19015 T19017 arg2Of signalling,organised
R12586 T19017 T19013 arg1Of organised,how
R12587 T19017 T19016 arg2Of organised,is
R12588 T19022 T19021 arg1Of importantly,more
R12589 T19024 T19012 arg3Of how,clarify
R12590 T19026 T19025 arg1Of knowledge,this
R12591 T19026 T19027 arg1Of knowledge,may
R12592 T19026 T19028 arg1Of knowledge,lead
R12593 T19028 T19024 arg1Of lead,how
R12594 T19028 T19027 arg2Of lead,may
R12595 T19028 T19029 arg1Of lead,to
R12596 T19031 T19029 arg2Of treatments,to
R12597 T19031 T19030 arg1Of treatments,new
R12598 T19031 T19032 arg1Of treatments,for
R12599 T19034 T19032 arg2Of diseases,for
R12600 T19034 T19033 arg1Of diseases,inflammatory
R12601 T19034 T19036 arg1Of diseases,as
R12602 T19036 T19035 arg1Of as,such
R12603 T19037 T19036 arg2Of RA,as
R12928 T19642 T19640 arg1Of signalling,Canonical
R12929 T19642 T19641 arg1Of signalling,NF-κB
R12930 T19642 T19643 arg1Of signalling,and
R12931 T19645 T19643 arg2Of regulators,and
R12932 T19645 T19644 arg1Of regulators,negative
R12933 T19647 T19646 arg1Of engagement,Ligand
R12934 T19647 T19648 arg1Of engagement,of
R12935 T19647 T19662 arg1Of engagement,trigger
R12936 T19651 T19648 arg2Of receptors,of
R12937 T19651 T19649 arg1Of receptors,specific
R12938 T19651 T19650 arg1Of receptors,membrane
R12939 T19651 T19653 arg1Of receptors,as
R12940 T19653 T19652 arg1Of as,such
R12941 T19654 T19655 arg1Of TNFR1,","
R12942 T19655 T19657 arg1Of ",",","
R12943 T19656 T19655 arg2Of CD40,","
R12944 T19657 T19660 arg1Of ",",and
R12945 T19658 T19657 arg2Of RANK,","
R12946 T19660 T19653 arg2Of and,as
R12947 T19660 T19659 arg1Of and,","
R12948 T19661 T19660 arg2Of TLR4,and
R12949 T19664 T19662 arg2Of recruitment,trigger
R12950 T19664 T19663 arg1Of recruitment,the
R12951 T19664 T19665 arg1Of recruitment,of
R12952 T19668 T19666 arg1Of proteins,specific
R12953 T19668 T19667 arg1Of proteins,adaptor
R12954 T19668 T19669 arg1Of proteins,(
R12955 T19668 T19692 arg1Of proteins,","
R12956 T19675 T19670 arg1Of protein,TNF
R12957 T19675 T19671 arg1Of protein,receptor
R12958 T19675 T19672 arg1Of protein,1-associated
R12959 T19675 T19673 arg1Of protein,death
R12960 T19675 T19674 arg1Of protein,domain
R12961 T19675 T19676 arg1Of protein,(
R12962 T19675 T19679 arg1Of protein,","
R12963 T19677 T19676 arg2Of TRADD,(
R12964 T19678 T19676 arg3Of ),(
R12965 T19679 T19681 arg1Of ",",","
R12966 T19680 T19679 arg2Of MyD88,","
R12967 T19681 T19683 arg1Of ",",","
R12968 T19682 T19681 arg2Of MAL,","
R12969 T19683 T19669 arg2Of ",",(
R12970 T19687 T19683 arg2Of IFNβ,","
R12971 T19687 T19684 arg1Of IFNβ,TIR
R12972 T19687 T19685 arg1Of IFNβ,domain-containing
R12973 T19687 T19686 arg1Of IFNβ,adaptor-inducing
R12974 T19687 T19688 arg1Of IFNβ,(
R12975 T19689 T19688 arg2Of TRIF,(
R12976 T19690 T19688 arg3Of ),(
R12977 T19691 T19669 arg3Of ),(
R12978 T19692 T19665 arg2Of ",",of
R12979 T19692 T19714 arg1Of ",",to
R12980 T19693 T19694 arg1Of kinases,(
R12981 T19693 T19702 arg1Of kinases,and
R12982 T19695 T19694 arg2Of RIP1,(
R12983 T19695 T19696 arg1Of RIP1,","
R12984 T19695 T19698 arg1Of RIP1,","
R12985 T19697 T19696 arg2Of IRAK1,","
R12986 T19699 T19698 arg2Of IRAK4,","
R12987 T19700 T19694 arg3Of ),(
R12988 T19702 T19692 arg2Of and,","
R12989 T19702 T19701 arg1Of and,","
R12990 T19704 T19702 arg2Of ligases,and
R12991 T19704 T19703 arg1Of ligases,ubiquitin
R12992 T19704 T19705 arg1Of ligases,(
R12993 T19706 T19707 arg1Of TRAF2,","
R12994 T19707 T19709 arg1Of ",",","
R12995 T19708 T19707 arg2Of TRAF6,","
R12996 T19709 T19705 arg2Of ",",(
R12997 T19709 T19711 arg1Of ",",","
R12998 T19710 T19709 arg2Of cIAP1,","
R12999 T19712 T19711 arg2Of cIAP2,","
R13 T18 T19 arg1Of NF-κB,plays
R13000 T19713 T19705 arg3Of ),(
R13001 T19716 T19714 arg2Of receptor,to
R13002 T19716 T19715 arg1Of receptor,the
R13003 T19718 T19717 arg1Of polyubiquitination,K63-linked
R13004 T19718 T19719 arg1Of polyubiquitination,of
R13005 T19718 T19726 arg1Of polyubiquitination,is
R13006 T19718 T19727 arg2Of polyubiquitination,recognised
R13007 T19720 T19719 arg2Of TRAFs,of
R13008 T19720 T19721 arg1Of TRAFs,","
R13009 T19722 T19723 arg1Of RIP1,and
R13010 T19723 T19721 arg2Of and,","
R13011 T19724 T19723 arg2Of IRAK1,and
R13012 T19727 T19725 arg1Of recognised,","
R13013 T19727 T19726 arg2Of recognised,is
R13014 T19727 T19733 arg1Of recognised,","
R13015 T19727 T19734 modOf recognised,resulting
R13016 T19729 T19730 arg1Of NEMO,and
R13017 T19731 T19730 arg2Of TAB,and
R13018 T19732 T19727 arg1Of proteins,recognised
R13019 T19732 T19728 arg2Of proteins,by
R13020 T19732 T19729 arg1Of proteins,NEMO
R13021 T19732 T19731 arg1Of proteins,TAB
R13022 T19734 T19735 arg1Of resulting,in
R13023 T19737 T19738 arg1Of recruitment,and
R13024 T19738 T19735 arg2Of and,in
R13025 T19738 T19736 arg1Of and,the
R13026 T19738 T19740 arg1Of and,of
R13027 T19739 T19738 arg2Of activation,and
R13028 T19742 T19743 arg1Of IKK2,and
R13029 T19743 T19740 arg2Of and,of
R13030 T19743 T19741 arg1Of and,respectively
R13031 T19744 T19743 arg2Of TAK1,and
R13032 T19745 T19747 arg1Of TAK1,phosphorylates
R13033 T19745 T19749 arg1Of TAK1,activates
R13034 T19747 T19748 arg1Of phosphorylates,and
R13035 T19748 T19746 arg1Of and,then
R13036 T19749 T19748 arg2Of activates,and
R13037 T19750 T19747 arg2Of IKK2,phosphorylates
R13038 T19750 T19749 arg2Of IKK2,activates
R13039 T19750 T19751 arg1Of IKK2,","
R13040 T19750 T19752 arg1Of IKK2,which
R13041 T19750 T19755 arg1Of IKK2,phosphorylates
R13042 T19750 T19758 arg1Of IKK2,triggering
R13043 T19754 T19753 arg2Of turn,in
R13044 T19755 T19753 arg1Of phosphorylates,in
R13045 T19755 T19757 arg1Of phosphorylates,","
R13046 T19755 T19758 modOf phosphorylates,triggering
R13047 T19756 T19755 arg2Of IκBα,phosphorylates
R13048 T19761 T19760 arg1Of ubiquitination,K48-linked
R13049 T19761 T19762 arg1Of ubiquitination,and
R13050 T19762 T19758 arg2Of and,triggering
R13051 T19762 T19759 arg1Of and,its
R13052 T19764 T19762 arg2Of degradation,and
R13053 T19764 T19763 arg1Of degradation,proteasomal
R13054 T19765 T19766 arg1Of This,allows
R13055 T19767 T19766 arg2Of NF-κB,allows
R13056 T19767 T19768 arg1Of NF-κB,(
R13057 T19767 T19780 arg1Of NF-κB,translocate
R13058 T19767 T19785 arg1Of NF-κB,promote
R13059 T19770 T19768 arg2Of shown,(
R13060 T19770 T19769 arg1Of shown,here
R13061 T19770 T19771 arg1Of shown,as
R13062 T19773 T19771 arg2Of heterodimer,as
R13063 T19773 T19772 arg1Of heterodimer,a
R13064 T19773 T19774 arg1Of heterodimer,of
R13065 T19775 T19776 arg1Of p65,and
R13066 T19776 T19774 arg2Of and,of
R13067 T19777 T19776 arg2Of p50,and
R13068 T19778 T19768 arg3Of ),(
R13069 T19780 T19781 arg1Of translocate,to
R13070 T19780 T19784 arg1Of translocate,and
R13071 T19783 T19781 arg2Of nucleus,to
R13072 T19783 T19782 arg1Of nucleus,the
R13073 T19784 T19766 arg3Of and,allows
R13074 T19784 T19779 arg1Of and,to
R13075 T19785 T19784 arg2Of promote,and
R13076 T19788 T19785 arg2Of expression,promote
R13077 T19788 T19786 arg1Of expression,target
R13078 T19788 T19787 arg1Of expression,gene
R13079 T19789 T19790 arg1Of TRAF1,","
R13080 T19789 T19791 arg1Of TRAF1,which
R13081 T19789 T19792 arg1Of TRAF1,has
R13082 T19789 T19798 arg1Of TRAF1,can
R13083 T19789 T19800 arg1Of TRAF1,regulate
R13084 T19789 T19807 arg1Of TRAF1,competing
R13085 T19796 T19792 arg2Of activity,has
R13086 T19796 T19793 arg1Of activity,no
R13087 T19796 T19794 arg1Of activity,ubiquitin
R13088 T19796 T19795 arg1Of activity,ligase
R13089 T19800 T19797 arg1Of regulate,","
R13090 T19800 T19798 arg2Of regulate,can
R13091 T19800 T19799 arg1Of regulate,negatively
R13092 T19800 T19803 arg1Of regulate,","
R13093 T19800 T19806 arg1Of regulate,by
R13094 T19802 T19800 arg2Of activation,regulate
R13095 T19802 T19801 arg1Of activation,NF-κB
R13096 T19805 T19804 arg1Of probably,most
R13097 T19806 T19805 arg1Of by,probably
R13098 T19807 T19806 arg2Of competing,by
R13099 T19807 T19808 arg1Of competing,with
R13100 T19810 T19808 arg2Of TRAFs,with
R13101 T19810 T19809 arg1Of TRAFs,other
R13102 T19811 T19812 arg1Of A20,and
R13103 T19812 T19814 arg1Of and,are
R13104 T19812 T19815 arg1Of and,deubiquitinating
R13105 T19813 T19812 arg2Of CYLD,and
R13106 T19815 T19814 arg2Of deubiquitinating,are
R13107 T19816 T19815 arg2Of enzymes,deubiquitinating
R13108 T19816 T19817 arg1Of enzymes,that
R13109 T19816 T19818 arg1Of enzymes,control
R13110 T19816 T19822 arg1Of enzymes,targeting
R13111 T19818 T19821 arg1Of control,by
R13112 T19820 T19818 arg2Of activation,control
R13113 T19820 T19819 arg1Of activation,NF-κB
R13114 T19822 T19821 arg2Of targeting,by
R13115 T19825 T19822 arg2Of proteins,targeting
R13116 T19825 T19823 arg1Of proteins,specific
R13117 T19825 T19824 arg1Of proteins,signalling
R13118 T19825 T19826 arg1Of proteins,including
R13119 T19827 T19828 arg1Of RIP1,and
R13120 T19828 T19826 arg2Of and,including
R13121 T19828 T19830 arg1Of and,","
R13122 T19828 T19831 arg2Of and,to
R13123 T19828 T19832 arg1Of and,which
R13124 T19829 T19828 arg2Of TRAF6,and
R13125 T19833 T19834 arg1Of they,are
R13126 T19833 T19835 arg2Of they,recruited
R13127 T19835 T19834 arg2Of recruited,are
R13128 T19835 T19836 modOf recruited,using
R13129 T19835 T19844 arg1Of recruited,and
R13130 T19840 T19836 arg2Of proteins,using
R13131 T19840 T19837 arg1Of proteins,specific
R13132 T19840 T19838 arg1Of proteins,ubiquitin-binding
R13133 T19840 T19839 arg1Of proteins,adaptor
R13134 T19840 T19842 arg1Of proteins,as
R13135 T19842 T19841 arg1Of as,such
R13136 T19843 T19842 arg2Of ABIN-1,as
R13137 T19844 T19831 arg1Of and,to
R13138 T19846 T19845 arg1Of miR-146,p62.
R13139 T19846 T19847 arg1Of miR-146,is
R1314 T1848 T1849 arg1Of NF-κB,is
R13140 T19846 T19848 arg2Of miR-146,thought
R13141 T19846 T19851 arg1Of miR-146,regulate
R13142 T19846 T19855 arg1Of miR-146,inhibiting
R13143 T19848 T19844 arg2Of thought,and
R13144 T19848 T19847 arg2Of thought,is
R13145 T19851 T19848 arg3Of regulate,thought
R13146 T19851 T19849 arg1Of regulate,to
R13147 T19851 T19850 arg1Of regulate,negatively
R13148 T19851 T19854 arg1Of regulate,by
R13149 T19853 T19851 arg2Of signalling,regulate
R1315 T1848 T1850 arg1Of NF-κB,central
R13150 T19853 T19852 arg1Of signalling,TLR
R13151 T19855 T19854 arg2Of inhibiting,by
R13152 T19856 T19855 arg2Of expression,inhibiting
R13153 T19856 T19857 arg1Of expression,of
R13154 T19858 T19859 arg1Of IRAK1,and
R13155 T19859 T19857 arg2Of and,of
R13156 T19860 T19859 arg2Of TRAF6,and
R13157 T19864 T19863 arg1Of signalling,TLR
R13158 T19864 T19865 arg1Of signalling,can
R13159 T19864 T19867 arg1Of signalling,be
R1316 T1849 T1847 arg2Of is,Since
R13160 T19864 T19868 arg2Of signalling,inhibited
R13161 T19868 T19861 arg1Of inhibited,Finally
R13162 T19868 T19862 arg1Of inhibited,","
R13163 T19868 T19865 arg2Of inhibited,can
R13164 T19868 T19866 arg1Of inhibited,also
R13165 T19868 T19867 arg2Of inhibited,be
R13166 T19873 T19868 arg1Of SIGIRR,inhibited
R13167 T19873 T19869 arg2Of SIGIRR,by
R13168 T19873 T19870 arg1Of SIGIRR,the
R13169 T19873 T19871 arg1Of SIGIRR,transmembrane
R1317 T1849 T1862 arg1Of is,with
R13170 T19873 T19872 arg1Of SIGIRR,protein
R13171 T19873 T19874 arg1Of SIGIRR,","
R13172 T19873 T19875 arg1Of SIGIRR,which
R13173 T19873 T19876 arg1Of SIGIRR,has
R13174 T19873 T19877 arg1Of SIGIRR,been
R13175 T19873 T19878 arg2Of SIGIRR,proposed
R13176 T19873 T19880 arg1Of SIGIRR,compete
R13177 T19878 T19876 arg2Of proposed,has
R13178 T19878 T19877 arg2Of proposed,been
R13179 T19880 T19878 arg3Of compete,proposed
R1318 T1850 T1849 arg2Of central,is
R13180 T19880 T19879 arg1Of compete,to
R13181 T19880 T19881 arg1Of compete,with
R13182 T19882 T19881 arg2Of TLR4,with
R13183 T19882 T19883 arg1Of TLR4,for
R13184 T19884 T19883 arg2Of binding,for
R13185 T19884 T19885 arg1Of binding,to
R13186 T19886 T19887 arg1Of IRAK1,and
R13187 T19887 T19885 arg2Of and,to
R13188 T19888 T19887 arg2Of TRAF6,and
R13189 T19890 T19889 arg1Of expression,The
R1319 T1850 T1851 arg1Of central,to
R13190 T19890 T19891 arg1Of expression,of
R13191 T19890 T19898 arg1Of expression,is
R13192 T19890 T19902 arg1Of expression,implicating
R13193 T19892 T19891 arg2Of many,of
R13194 T19892 T19893 arg1Of many,of
R13195 T19897 T19893 arg2Of molecules,of
R13196 T19897 T19894 arg1Of molecules,these
R13197 T19897 T19895 arg1Of molecules,negative
R13198 T19897 T19896 arg1Of molecules,regulatory
R13199 T19898 T19901 arg1Of is,","
R1320 T1853 T1851 arg2Of process,to
R13200 T19898 T19902 modOf is,implicating
R13201 T19899 T19898 arg2Of NF-κB,is
R13202 T19899 T19900 arg1Of NF-κB,dependent
R13203 T19902 T19904 arg1Of implicating,in
R13204 T19903 T19902 arg2Of them,implicating
R13205 T19908 T19904 arg2Of regulation,in
R13206 T19908 T19905 arg1Of regulation,the
R13207 T19908 T19906 arg1Of regulation,negative
R13208 T19908 T19907 arg1Of regulation,feedback
R13209 T19908 T19909 arg1Of regulation,of
R1321 T1853 T1852 arg1Of process,the
R13210 T19911 T19909 arg2Of activation,of
R13211 T19911 T19910 arg1Of activation,NF-κB
R13212 T19912 T19913 arg1Of ABIN,","
R13213 T19912 T19918 arg1Of ABIN,;
R13214 T19915 T19913 arg2Of inhibitor,","
R13215 T19915 T19914 arg1Of inhibitor,A20-binding
R13216 T19915 T19916 arg1Of inhibitor,of
R13217 T19917 T19916 arg2Of NF-κB,of
R13218 T19919 T19918 arg2Of cIAP,;
R13219 T19919 T19920 arg1Of cIAP,","
R1322 T1853 T1854 arg1Of process,of
R13220 T19922 T19920 arg2Of inhibitor,","
R13221 T19922 T19921 arg1Of inhibitor,cellular
R13222 T19922 T19923 arg1Of inhibitor,of
R13223 T19924 T19923 arg2Of apoptosis,of
R13224 T19926 T19927 arg1Of CYLD,","
R13225 T19928 T19927 arg2Of cylindromatosis,","
R13226 T19930 T19929 arg2Of IKK,;
R13227 T19930 T19931 arg1Of IKK,","
R13228 T19930 T19934 arg1Of IKK,;
R13229 T19933 T19931 arg2Of kinase,","
R1323 T1853 T1856 arg1Of process,in
R13230 T19933 T19932 arg1Of kinase,IκB
R13231 T19935 T19934 arg2Of IκB,;
R13232 T19935 T19936 arg1Of IκB,","
R13233 T19935 T19940 arg1Of IκB,;
R13234 T19937 T19936 arg2Of inhibitor,","
R13235 T19937 T19938 arg1Of inhibitor,of
R13236 T19939 T19938 arg2Of NF-κB,of
R13237 T19941 T19940 arg2Of IRAK,;
R13238 T19941 T19942 arg1Of IRAK,","
R13239 T19944 T19942 arg2Of kinase,","
R1324 T1853 T1858 arg1Of process,","
R13240 T19944 T19943 arg1Of kinase,IL-1R-associated
R13241 T19946 T19947 arg1Of MyD88,","
R13242 T19952 T19947 arg2Of gene,","
R13243 T19952 T19948 arg1Of gene,myeloid
R13244 T19952 T19949 arg1Of gene,differentiation
R13245 T19952 T19950 arg1Of gene,primary
R13246 T19952 T19951 arg1Of gene,response
R13247 T19952 T19953 arg1Of gene,88
R13248 T19955 T19954 arg2Of NEMO,;
R13249 T19955 T19956 arg1Of NEMO,","
R1325 T1855 T1854 arg2Of inflammation,of
R13250 T19959 T19956 arg2Of modulator,","
R13251 T19959 T19957 arg1Of modulator,NF-κB
R13252 T19959 T19958 arg1Of modulator,essential
R13253 T19961 T19962 arg1Of NF,","
R13254 T19964 T19962 arg2Of factor,","
R13255 T19964 T19963 arg1Of factor,nuclear
R13256 T19966 T19967 arg1Of RANK,","
R13257 T19966 T19972 arg1Of RANK,;
R13258 T19969 T19967 arg2Of activator,","
R13259 T19969 T19968 arg1Of activator,receptor
R1326 T1857 T1856 arg2Of RA,in
R13260 T19969 T19970 arg1Of activator,of
R13261 T19971 T19970 arg2Of NF-κB,of
R13262 T19973 T19972 arg2Of RIP1,;
R13263 T19973 T19974 arg1Of RIP1,","
R13264 T19973 T19979 arg1Of RIP1,;
R13265 T19977 T19974 arg2Of protein,","
R13266 T19977 T19975 arg1Of protein,receptor
R13267 T19977 T19976 arg1Of protein,interacting
R13268 T19977 T19978 arg1Of protein,1
R13269 T19980 T19979 arg2Of SIGIRR,;
R1327 T1861 T1858 arg2Of deals,","
R13270 T19980 T19981 arg1Of SIGIRR,","
R13271 T19982 T19981 arg2Of single-immunoglobulinIL-1,","
R13272 T19982 T19983 arg1Of single-immunoglobulinIL-1,receptor-related
R13273 T19985 T19986 arg1Of TIR,","
R13274 T19985 T19989 arg1Of TIR,;
R13275 T19988 T19986 arg2Of receptor/IL-1R,","
R13276 T19988 T19987 arg1Of receptor/IL-1R,Toll-like
R13277 T19990 T19989 arg2Of TRAF,;
R13278 T19990 T19991 arg1Of TRAF,","
R13279 T19990 T19995 arg1Of TRAF,;
R1328 T1861 T1859 arg1Of deals,much
R13280 T19994 T19991 arg2Of factor,","
R13281 T19994 T19992 arg1Of factor,TNF
R13282 T19994 T19993 arg1Of factor,receptor-associated
R13283 T19996 T19995 arg2Of TLR,;
R13284 T19996 T19997 arg1Of TLR,","
R13285 T19996 T20000 arg1Of TLR,;
R13286 T19999 T19997 arg2Of receptor,","
R13287 T19999 T19998 arg1Of receptor,Toll-like
R13288 T20001 T20000 arg2Of TNF,;
R13289 T20001 T20002 arg1Of TNF,","
R1329 T1861 T1860 arg1Of deals,research
R13290 T20005 T20002 arg2Of factor,","
R13291 T20005 T20003 arg1Of factor,tumour
R13292 T20005 T20004 arg1Of factor,necrosis
R1330 T1864 T1862 arg2Of identification,with
R1331 T1864 T1863 arg1Of identification,the
R1332 T1864 T1865 arg1Of identification,of
R1333 T1868 T1865 arg2Of triggers,of
R1334 T1868 T1866 arg1Of triggers,the
R1335 T1868 T1867 arg1Of triggers,molecular
R1336 T1869 T1870 arg1Of that,activate
R1337 T1870 T1847 arg1Of activate,Since
R1338 T1870 T1872 arg1Of activate,in
R1339 T1871 T1870 arg2Of NF-κB,activate
R1340 T1873 T1872 arg2Of RA,in
R1341 T1874 T1875 arg1Of It,is
R1342 T1874 T1877 arg2Of It,accepted
R1343 T1877 T1875 arg2Of accepted,is
R1344 T1877 T1876 arg1Of accepted,well
R1345 T1880 T1879 arg1Of cytokines,proinflammatory
R1346 T1880 T1882 arg1Of cytokines,as
R1347 T1880 T1886 arg1Of cytokines,play
R1348 T1882 T1881 arg1Of as,such
R1349 T1883 T1884 arg1Of TNF,and
R1350 T1884 T1882 arg2Of and,as
R1351 T1885 T1884 arg2Of IL-1,and
R1352 T1886 T1891 arg1Of play,and
R1353 T1889 T1886 arg2Of role,play
R1354 T1889 T1887 arg1Of role,an
R1355 T1889 T1888 arg1Of role,important
R1356 T1891 T1877 arg3Of and,accepted
R1357 T1891 T1878 arg1Of and,that
R1358 T1891 T1890 arg1Of and,","
R1359 T1892 T1893 arg1Of administration,of
R1360 T1892 T1896 arg1Of administration,is
R1361 T1895 T1893 arg2Of antagonists,of
R1362 T1895 T1894 arg1Of antagonists,TNF
R1363 T1896 T1891 arg2Of is,and
R1364 T1899 T1896 arg2Of treatment,is
R1365 T1899 T1897 arg1Of treatment,an
R1366 T1899 T1898 arg1Of treatment,effective
R1367 T1899 T1900 arg1Of treatment,for
R1368 T1902 T1900 arg2Of RA,for
R1369 T1902 T1901 arg1Of RA,severe
R1370 T1902 T1903 arg1Of RA,(
R1371 T1904 T1903 arg2Of reviewed,(
R1372 T1904 T1905 arg1Of reviewed,in
R1373 T1904 T1906 arg1Of reviewed,[
R1374 T1907 T1906 arg2Of 9,[
R1375 T1908 T1906 arg3Of ],[
R1376 T1909 T1903 arg3Of ),(
R1377 T1910 T1911 arg1Of TNF,and
R1378 T1911 T1913 arg1Of and,are
R1379 T1912 T1911 arg2Of IL-1,and
R1380 T1913 T1920 arg1Of are,and
R1381 T1916 T1915 arg1Of potent,very
R1382 T1917 T1913 arg2Of activators,are
R1383 T1917 T1914 arg1Of activators,both
R1384 T1917 T1916 arg1Of activators,potent
R1385 T1917 T1918 arg1Of activators,of
R1386 T1919 T1918 arg2Of NF-κB,of
R1387 T1921 T1922 arg1Of it,can
R1388 T1921 T1923 arg1Of it,be
R1389 T1921 T1924 arg2Of it,expected
R1390 T1924 T1920 arg2Of expected,and
R1391 T1924 T1922 arg2Of expected,can
R1392 T1924 T1923 arg2Of expected,be
R1393 T1927 T1926 arg1Of activation,NF-κB
R1394 T1927 T1928 arg1Of activation,by
R1395 T1927 T1931 arg1Of activation,mediates
R1396 T1930 T1928 arg2Of cytokines,by
R1397 T1930 T1929 arg1Of cytokines,these
R1398 T1931 T1924 arg3Of mediates,expected
R1399 T1931 T1925 arg1Of mediates,that
R14 T19 T22 arg1Of plays,in
R1400 T1932 T1931 arg2Of most,mediates
R14009 T21534 T21532 arg1Of signalling,Noncanonical
R1401 T1932 T1933 arg1Of most,of
R14010 T21534 T21533 arg1Of signalling,NF-κB
R14011 T21535 T21536 arg1Of CD40,and
R14012 T21536 T21538 arg1Of and,can
R14013 T21536 T21539 arg1Of and,activate
R14014 T21537 T21536 arg2Of RANK,and
R14015 T21539 T21538 arg2Of activate,can
R14016 T21543 T21539 arg2Of pathway,activate
R14017 T21543 T21540 arg1Of pathway,the
R14018 T21543 T21541 arg1Of pathway,noncanonical
R14019 T21543 T21542 arg1Of pathway,NF-κB
R1402 T1936 T1933 arg2Of activities,of
R14020 T21543 T21544 arg1Of pathway,that
R14021 T21543 T21545 arg1Of pathway,is
R14022 T21543 T21546 arg1Of pathway,dependent
R14023 T21546 T21545 arg2Of dependent,is
R14024 T21546 T21547 arg1Of dependent,on
R14025 T21548 T21547 arg2Of NF-κB,on
R14026 T21548 T21549 arg1Of NF-κB,inducing
R14027 T21552 T21551 arg2Of NIK,(
R14028 T21553 T21551 arg3Of ),(
R14029 T21555 T21549 arg2Of levels,inducing
R1403 T1936 T1934 arg1Of activities,their
R14030 T21555 T21550 arg1Of levels,kinase
R14031 T21555 T21551 arg1Of levels,(
R14032 T21555 T21554 arg1Of levels,expression
R14033 T21558 T21556 arg2Of cells,In
R14034 T21558 T21557 arg1Of cells,unstimulated
R14035 T21559 T21560 arg1Of NIK,forms
R14036 T21560 T21556 arg1Of forms,In
R14037 T21560 T21584 arg1Of forms,","
R14038 T21563 T21560 arg2Of complex,forms
R14039 T21563 T21561 arg1Of complex,a
R1404 T1936 T1935 arg1Of activities,pro-inflammatory
R14040 T21563 T21562 arg1Of complex,cytosolic
R14041 T21563 T21564 arg1Of complex,with
R14042 T21567 T21565 arg1Of ligases,the
R14043 T21567 T21566 arg1Of ligases,ubiquitin
R14044 T21568 T21569 arg1Of TRAF2,","
R14045 T21569 T21571 arg1Of ",",and
R14046 T21570 T21569 arg2Of TRAF3,","
R14047 T21571 T21564 arg2Of and,with
R14048 T21571 T21567 arg1Of and,ligases
R14049 T21571 T21573 arg1Of and,","
R1405 T1936 T1937 arg1Of activities,in
R14050 T21571 T21574 arg1Of and,which
R14051 T21571 T21575 arg1Of and,facilitates
R14052 T21572 T21571 arg2Of cIAP1/2,and
R14053 T21577 T21578 arg1Of K48-linked,polyubiquitination
R14054 T21577 T21579 arg1Of K48-linked,and
R14055 T21580 T21579 arg2Of proteasomal,and
R14056 T21581 T21575 arg2Of degradation,facilitates
R14057 T21581 T21576 arg1Of degradation,the
R14058 T21581 T21577 arg1Of degradation,K48-linked
R14059 T21581 T21580 arg1Of degradation,proteasomal
R1406 T1938 T1937 arg2Of RA,in
R14060 T21581 T21582 arg1Of degradation,of
R14061 T21583 T21582 arg2Of NIK,of
R14062 T21585 T21560 arg3Of keeping,forms
R14063 T21587 T21585 arg2Of levels,keeping
R14064 T21587 T21586 arg1Of levels,NIK
R14065 T21587 T21588 arg1Of levels,low
R14066 T21588 T21585 arg3Of low,keeping
R14067 T21591 T21589 arg2Of binding,Upon
R14068 T21591 T21590 arg1Of binding,ligand
R14069 T21593 T21594 arg1Of TRAF3,is
R1407 T1938 T1939 arg1Of RA,(
R14070 T21593 T21595 arg2Of TRAF3,recruited
R14071 T21595 T21589 arg1Of recruited,Upon
R14072 T21595 T21592 arg1Of recruited,","
R14073 T21595 T21594 arg2Of recruited,is
R14074 T21595 T21596 arg1Of recruited,to
R14075 T21598 T21596 arg2Of receptor,to
R14076 T21598 T21597 arg1Of receptor,the
R14077 T21598 T21599 arg1Of receptor,","
R14078 T21598 T21600 arg1Of receptor,where
R14079 T21601 T21602 arg1Of TRAF2,directs
R1408 T1940 T1939 arg2Of reviewed,(
R14080 T21602 T21600 arg2Of directs,where
R14081 T21602 T21608 arg1Of directs,","
R14082 T21602 T21609 modOf directs,resulting
R14083 T21605 T21602 arg2Of polyubiquitination,directs
R14084 T21605 T21603 arg1Of polyubiquitination,nondegradative
R14085 T21605 T21604 arg1Of polyubiquitination,K63-linked
R14086 T21605 T21606 arg1Of polyubiquitination,of
R14087 T21607 T21606 arg2Of cIAP1/2,of
R14088 T21609 T21610 arg1Of resulting,in
R14089 T21612 T21610 arg2Of activation,in
R1409 T1940 T1941 arg1Of reviewed,in
R14090 T21612 T21611 arg1Of activation,their
R14091 T21614 T21613 arg1Of cIAP1/2,Subsequently
R14092 T21614 T21615 arg1Of cIAP1/2,directs
R14093 T21618 T21617 arg1Of polyubiquitination,K48-linked
R14094 T21618 T21619 arg1Of polyubiquitination,to
R14095 T21618 T21623 arg1Of polyubiquitination,than
R14096 T21620 T21619 arg2Of TRAF3,to
R14097 T21623 T21615 arg2Of than,directs
R14098 T21623 T21616 arg1Of than,its
R14099 T21623 T21621 arg1Of than,","
R1410 T1940 T1942 arg1Of reviewed,[
R14100 T21623 T21622 arg1Of than,rather
R14101 T21624 T21623 arg2Of NIK,than
R14102 T21627 T21625 arg2Of result,As
R14103 T21627 T21626 arg1Of result,a
R14104 T21629 T21630 arg1Of TRAF3,is
R14105 T21629 T21631 arg2Of TRAF3,degraded
R14106 T21631 T21630 arg2Of degraded,is
R14107 T21631 T21632 arg1Of degraded,and
R14108 T21632 T21625 arg1Of and,As
R14109 T21632 T21628 arg1Of and,","
R1411 T1943 T1942 arg2Of 3,[
R14110 T21632 T21636 arg1Of and,","
R14111 T21632 T21637 modOf and,resulting
R14112 T21633 T21634 arg1Of NIK,is
R14113 T21633 T21635 arg2Of NIK,stabilised
R14114 T21635 T21632 arg2Of stabilised,and
R14115 T21635 T21634 arg2Of stabilised,is
R14116 T21637 T21638 arg1Of resulting,in
R14117 T21641 T21638 arg2Of levels,in
R14118 T21641 T21639 arg2Of levels,increased
R14119 T21641 T21640 arg1Of levels,NIK
R1412 T1944 T1942 arg3Of ],[
R14120 T21641 T21642 arg1Of levels,in
R14121 T21644 T21642 arg2Of cell,in
R14122 T21644 T21643 arg1Of cell,the
R14123 T21645 T21647 arg1Of NIK,phosphorylates
R14124 T21645 T21649 arg1Of NIK,activates
R14125 T21647 T21648 arg1Of phosphorylates,and
R14126 T21648 T21646 arg1Of and,then
R14127 T21649 T21648 arg2Of activates,and
R14128 T21650 T21647 arg2Of IKK1,phosphorylates
R14129 T21650 T21649 arg2Of IKK1,activates
R1413 T1945 T1939 arg3Of ),(
R14130 T21650 T21651 arg1Of IKK1,","
R14131 T21650 T21652 arg1Of IKK1,which
R14132 T21650 T21653 arg1Of IKK1,mediates
R14133 T21656 T21653 arg2Of phosphorylation,mediates
R14134 T21656 T21654 arg1Of phosphorylation,NF-κB
R14135 T21656 T21655 arg1Of phosphorylation,p100
R14136 T21657 T21658 arg1Of This,is
R14137 T21657 T21659 arg2Of This,followed
R14138 T21659 T21658 arg2Of followed,is
R14139 T21661 T21662 arg1Of K48-linked,polyubiquitination
R1414 T1947 T1946 arg1Of activation,NF-κB
R14140 T21661 T21663 arg1Of K48-linked,and
R14141 T21665 T21663 arg2Of proteasomal,and
R14142 T21665 T21664 arg1Of proteasomal,partial
R14143 T21666 T21659 arg1Of degradation,followed
R14144 T21666 T21660 arg2Of degradation,by
R14145 T21666 T21661 arg1Of degradation,K48-linked
R14146 T21666 T21665 arg1Of degradation,proteasomal
R14147 T21666 T21667 arg1Of degradation,of
R14148 T21666 T21671 arg1Of degradation,","
R14149 T21666 T21672 arg1Of degradation,which
R1415 T1947 T1948 arg1Of activation,by
R14150 T21666 T21673 arg1Of degradation,forms
R14151 T21668 T21667 arg2Of p100,of
R14152 T21668 T21669 arg1Of p100,to
R14153 T21670 T21669 arg2Of p52,to
R14154 T21675 T21673 arg2Of heterodimer,forms
R14155 T21675 T21674 arg1Of heterodimer,a
R14156 T21675 T21676 arg1Of heterodimer,with
R14157 T21675 T21678 modOf heterodimer,to
R14158 T21677 T21676 arg2Of RelB,with
R14159 T21679 T21678 arg1Of activate,to
R1416 T1947 T1963 arg1Of activation,is
R14160 T21680 T21679 arg2Of transcription,activate
R14161 T21681 T21682 arg1Of Next,to
R14162 T21683 T21682 arg2Of TRAF3,to
R14163 T21685 T21686 arg1Of TRAF1,has
R14164 T21685 T21688 arg1Of TRAF1,been
R14165 T21685 T21689 arg2Of TRAF1,identified
R14166 T21689 T21681 arg1Of identified,Next
R14167 T21689 T21684 arg1Of identified,","
R14168 T21689 T21686 arg2Of identified,has
R14169 T21689 T21687 arg1Of identified,also
R1417 T1947 T1964 arg1Of activation,important
R14170 T21689 T21688 arg2Of identified,been
R14171 T21689 T21690 arg1Of identified,as
R14172 T21689 T21697 arg1Of identified,","
R14173 T21689 T21700 arg1Of identified,by
R14174 T21693 T21690 arg2Of regulator,as
R14175 T21693 T21691 arg1Of regulator,a
R14176 T21693 T21692 arg1Of regulator,negative
R14177 T21693 T21694 arg1Of regulator,of
R14178 T21696 T21694 arg2Of pathway,of
R14179 T21696 T21695 arg1Of pathway,this
R1418 T1950 T1948 arg2Of activator,by
R14180 T21699 T21698 arg1Of probably,most
R14181 T21700 T21699 arg1Of by,probably
R14182 T21701 T21700 arg2Of competing,by
R14183 T21701 T21702 arg1Of competing,with
R14184 T21701 T21718 arg1Of competing,;
R14185 T21707 T21702 arg2Of cIAP,with
R14186 T21707 T21703 arg1Of cIAP,other
R14187 T21707 T21704 arg1Of cIAP,TNF
R14188 T21707 T21705 arg1Of cIAP,receptor-associated
R14189 T21707 T21706 arg1Of cIAP,factors.
R1419 T1950 T1949 arg1Of activator,receptor
R14190 T21707 T21708 arg1Of cIAP,","
R14191 T21707 T21713 arg1Of cIAP,;
R14192 T21710 T21708 arg2Of inhibitor,","
R14193 T21710 T21709 arg1Of inhibitor,cellular
R14194 T21710 T21711 arg1Of inhibitor,of
R14195 T21712 T21711 arg2Of apoptosis,of
R14196 T21714 T21713 arg2Of IKK,;
R14197 T21714 T21715 arg1Of IKK,","
R14198 T21717 T21715 arg2Of kinase,","
R14199 T21717 T21716 arg1Of kinase,IκB
R1420 T1950 T1951 arg1Of activator,of
R14200 T21719 T21689 arg3Of NF,identified
R14201 T21719 T21720 arg1Of NF,","
R14202 T21719 T21723 arg1Of NF,;
R14203 T21722 T21720 arg2Of factor,","
R14204 T21722 T21721 arg1Of factor,nuclear
R14205 T21724 T21723 arg2Of RANK,;
R14206 T21724 T21725 arg1Of RANK,","
R14207 T21724 T21730 arg1Of RANK,;
R14208 T21727 T21725 arg2Of activator,","
R14209 T21727 T21726 arg1Of activator,receptor
R1421 T1952 T1951 arg2Of NF-κB,of
R14210 T21727 T21728 arg1Of activator,of
R14211 T21729 T21728 arg2Of NF-κB,of
R14212 T21731 T21730 arg2Of TRAF,;
R14213 T21731 T21732 arg1Of TRAF,","
R14214 T21731 T21736 arg1Of TRAF,;
R14215 T21735 T21732 arg2Of factor,","
R14216 T21735 T21733 arg1Of factor,TNF
R14217 T21735 T21734 arg1Of factor,receptor-associated
R14218 T21737 T21736 arg2Of TNF,;
R14219 T21737 T21738 arg1Of TNF,","
R1422 T1952 T1953 arg1Of NF-κB,(
R14220 T21741 T21738 arg2Of factor,","
R14221 T21741 T21739 arg1Of factor,tumour
R14222 T21741 T21740 arg1Of factor,necrosis
R1423 T1952 T1956 arg1Of NF-κB,","
R1424 T1954 T1953 arg2Of RANK,(
R1425 T1955 T1953 arg3Of ),(
R1426 T1961 T1956 arg2Of member,","
R1427 T1961 T1957 arg1Of member,a
R1428 T1961 T1958 arg1Of member,TNF
R1429 T1961 T1959 arg1Of member,receptor
R1430 T1961 T1960 arg1Of member,family
R1431 T1963 T1962 arg1Of is,","
R1432 T1963 T1968 arg1Of is,and
R1433 T1964 T1963 arg2Of important,is
R1434 T1964 T1965 arg1Of important,for
R1435 T1966 T1965 arg2Of osteoclastogenesis,for
R1436 T1968 T1967 arg1Of and,","
R1437 T1969 T1970 arg1Of defects,in
R1438 T1969 T1974 arg1Of defects,are
R1439 T1969 T1975 arg1Of defects,likely
R1440 T1969 T1977 arg1Of defects,be
R1441 T1969 T1978 arg2Of defects,involved
R1442 T1973 T1970 arg2Of signalling,in
R1443 T1973 T1971 arg1Of signalling,proper
R1444 T1973 T1972 arg1Of signalling,RANK-NF-κB
R1445 T1974 T1968 arg2Of are,and
R1446 T1975 T1974 arg2Of likely,are
R1447 T1978 T1975 arg2Of involved,likely
R1448 T1978 T1976 arg1Of involved,to
R1449 T1978 T1977 arg2Of involved,be
R1450 T1978 T1979 arg1Of involved,in
R1451 T1981 T1980 arg1Of pathology,RA
R1452 T1981 T1982 arg1Of pathology,and
R1453 T1982 T1979 arg2Of and,in
R1454 T1982 T1985 arg2Of and,associated
R1455 T1984 T1982 arg2Of diseases,and
R1456 T1984 T1983 arg1Of diseases,other
R1457 T1985 T1986 arg1Of associated,with
R1458 T1988 T1986 arg2Of loss,with
R1459 T1988 T1987 arg1Of loss,bone
R1460 T1988 T1989 arg1Of loss,[
R1461 T1990 T1989 arg2Of 7,[
R1462 T1991 T1989 arg3Of ],[
R1463 T1992 T1993 arg1Of CD40,is
R1464 T1998 T1993 arg2Of member,is
R1465 T1998 T1994 arg1Of member,another
R1466 T1998 T1995 arg1Of member,TNF
R1467 T1998 T1996 arg1Of member,receptor
R1468 T1998 T1997 arg1Of member,family
R1469 T1998 T1999 arg1Of member,that
R1470 T1998 T2000 arg1Of member,is
R1471 T1998 T2002 arg2Of member,expressed
R1472 T1998 T2034 arg1Of member,can
R1473 T1998 T2035 arg1Of member,be
R1474 T1998 T2036 arg2Of member,upregulated
R1475 T2002 T2000 arg2Of expressed,is
R1476 T2002 T2001 arg1Of expressed,functionally
R1477 T2002 T2003 arg1Of expressed,on
R1478 T2002 T2033 arg1Of expressed,and
R1479 T2005 T2003 arg2Of variety,on
R1480 T2005 T2004 arg1Of variety,a
R1481 T2005 T2006 arg1Of variety,of
R1482 T2008 T2007 arg1Of types,cell
R1483 T2008 T2009 arg1Of types,","
R1484 T2008 T2010 arg1Of types,including
R1485 T2008 T2023 arg1Of types,","
R1486 T2013 T2010 arg2Of fibroblasts,including
R1487 T2013 T2011 arg1Of fibroblasts,smooth
R1488 T2013 T2012 arg1Of fibroblasts,muscle
R1489 T2013 T2014 arg1Of fibroblasts,from
R1490 T2015 T2016 arg1Of normal,and
R1491 T2017 T2016 arg2Of RA,and
R1492 T2018 T2015 arg1Of patients,normal
R1493 T2018 T2017 arg1Of patients,RA
R1494 T2018 T2019 arg1Of patients,and
R1495 T2019 T2014 arg2Of and,from
R1496 T2022 T2019 arg2Of cells,and
R1497 T2022 T2020 arg1Of cells,RA
R1498 T2022 T2021 arg1Of cells,synovial
R1499 T2023 T2006 arg2Of ",",of
R15 T19 T31 arg1Of plays,and
R1500 T2025 T2024 arg1Of cells,B
R1501 T2025 T2026 arg1Of cells,","
R1502 T2026 T2029 arg1Of ",",and
R1503 T2027 T2026 arg2Of macrophages,","
R1504 T2029 T2023 arg2Of and,","
R1505 T2029 T2028 arg1Of and,","
R1506 T2031 T2029 arg2Of cells,and
R1507 T2031 T2030 arg1Of cells,dendritic
R1508 T2033 T2032 arg1Of and,","
R1509 T2036 T2033 arg2Of upregulated,and
R1510 T2036 T2034 arg2Of upregulated,can
R1511 T2036 T2035 arg2Of upregulated,be
R1512 T2039 T2036 arg1Of cytokines,upregulated
R1513 T2039 T2037 arg2Of cytokines,by
R1514 T2039 T2038 arg1Of cytokines,proinflammatory
R1515 T2039 T2040 arg1Of cytokines,including
R1516 T2041 T2040 arg2Of TNF,including
R1517 T2041 T2042 arg1Of TNF,[
R1518 T2043 T2042 arg2Of 10,[
R1519 T2044 T2042 arg3Of ],[
R1520 T2045 T2046 arg1Of Binding,of
R1521 T2045 T2067 arg1Of Binding,triggers
R1522 T2049 T2046 arg2Of ligand,of
R1523 T2049 T2047 arg1Of ligand,the
R1524 T2049 T2048 arg1Of ligand,CD40
R1525 T2049 T2050 arg1Of ligand,(
R1526 T2049 T2053 arg1Of ligand,","
R1527 T2049 T2054 arg1Of ligand,which
R1528 T2049 T2055 arg1Of ligand,is
R1529 T2049 T2057 arg2Of ligand,expressed
R1530 T2051 T2050 arg2Of CD154,(
R1531 T2052 T2050 arg3Of ),(
R1532 T2057 T2055 arg2Of expressed,is
R1533 T2057 T2056 arg1Of expressed,transiently
R1534 T2057 T2058 arg1Of expressed,on
R1535 T2060 T2058 arg2Of surface,on
R1536 T2060 T2059 arg1Of surface,the
R1537 T2060 T2061 arg1Of surface,of
R1538 T2065 T2061 arg2Of cells,of
R1539 T2065 T2062 arg2Of cells,activated
R1540 T2065 T2063 arg1Of cells,CD4+
R1541 T2065 T2064 arg1Of cells,T
R1542 T2067 T2066 arg1Of triggers,","
R1543 T2069 T2067 arg2Of activation,triggers
R1544 T2069 T2068 arg1Of activation,NF-κB
R1545 T2069 T2070 arg1Of activation,resulting
R1546 T2070 T2071 arg1Of resulting,in
R1547 T2073 T2072 arg1Of proliferation,fibroblast
R1548 T2073 T2074 arg1Of proliferation,and
R1549 T2074 T2071 arg2Of and,in
R1550 T2074 T2081 arg1Of and,","
R1551 T2074 T2082 arg1Of and,which
R1552 T2074 T2083 arg1Of and,contributes
R1553 T2075 T2074 arg2Of secretion,and
R1554 T2075 T2076 arg1Of secretion,of
R1555 T2078 T2077 arg1Of cytokines,proinflammatory
R1556 T2078 T2079 arg1Of cytokines,and
R1557 T2079 T2076 arg2Of and,of
R1558 T2080 T2079 arg2Of chemokines,and
R1559 T2083 T2084 arg1Of contributes,to
R1560 T2086 T2084 arg2Of destruction,to
R1561 T2086 T2085 arg1Of destruction,joint
R1562 T2089 T2090 arg1Of studies,with
R1563 T2089 T2096 arg1Of studies,led
R1564 T2089 T2115 arg1Of studies,are
R1565 T2089 T2117 arg2Of studies,required
R1566 T2092 T2091 arg1Of anti-CD40,antagonistic
R1567 T2092 T2093 arg1Of anti-CD40,or
R1568 T2093 T2090 arg2Of or,with
R1569 T2095 T2093 arg2Of antibodies,or
R1570 T2095 T2094 arg1Of antibodies,anti-CD154
R1571 T2096 T2097 arg1Of led,to
R1572 T2096 T2114 arg1Of led,but
R1573 T2099 T2097 arg2Of conclusion,to
R1574 T2099 T2098 arg1Of conclusion,the
R1575 T2102 T2101 arg1Of signals,CD40
R1576 T2102 T2103 arg1Of signals,may
R1577 T2102 T2104 arg1Of signals,be
R1578 T2102 T2105 arg1Of signals,important
R1579 T2104 T2099 arg2Of be,conclusion
R1580 T2104 T2100 arg1Of be,that
R1581 T2104 T2103 arg2Of be,may
R1582 T2105 T2104 arg2Of important,be
R1583 T2105 T2106 arg1Of important,at
R1584 T2109 T2106 arg2Of stages,at
R1585 T2109 T2107 arg1Of stages,the
R1586 T2109 T2108 arg1Of stages,initial
R1587 T2109 T2110 arg1Of stages,of
R1588 T2112 T2110 arg2Of induction,of
R1589 T2112 T2111 arg1Of induction,arthritis
R1590 T2114 T2087 arg1Of but,However
R1591 T2114 T2088 arg1Of but,","
R1592 T2114 T2113 arg1Of but,","
R1593 T2117 T2114 arg2Of required,but
R1594 T2117 T2115 arg2Of required,are
R1595 T2117 T2116 arg1Of required,not
R1596 T2117 T2118 arg1Of required,once
R1597 T2119 T2120 arg1Of disease,is
R1598 T2119 T2121 arg2Of disease,established
R1599 T2121 T2120 arg2Of established,is
R16 T21 T19 arg2Of roles,plays
R1600 T2121 T2122 arg1Of established,and
R1601 T2122 T2118 arg2Of and,once
R1602 T2124 T2123 arg1Of antibodies,pathogenic
R1603 T2124 T2125 arg1Of antibodies,are
R1604 T2124 T2127 arg1Of antibodies,present
R1605 T2125 T2122 arg2Of are,and
R1606 T2125 T2126 arg1Of are,already
R1607 T2125 T2128 arg1Of are,[
R1608 T2127 T2125 arg2Of present,are
R1609 T2129 T2128 arg2Of "11,12",[
R1610 T2130 T2128 arg3Of ],[
R1611 T2132 T2131 arg2Of expression,Enhanced
R1612 T2132 T2133 arg1Of expression,of
R1613 T2132 T2155 arg1Of expression,is
R1614 T2132 T2157 arg1Of expression,characteristic
R1615 T2139 T2133 arg2Of B-cell,of
R1616 T2139 T2134 arg1Of B-cell,the
R1617 T2139 T2135 arg1Of B-cell,TNF
R1618 T2139 T2136 arg1Of B-cell,receptor
R1619 T2139 T2137 arg1Of B-cell,family
R1620 T2139 T2138 arg1Of B-cell,member
R1621 T2139 T2140 arg1Of B-cell,activating
R1622 T2140 T2145 arg1Of activating,","
R1623 T2140 T2146 modOf activating,allowing
R1624 T2141 T2140 arg2Of factor,activating
R1625 T2141 T2142 arg1Of factor,(
R1626 T2143 T2142 arg2Of BAFF,(
R1627 T2144 T2142 arg3Of ),(
R1628 T2148 T2146 arg2Of survival,allowing
R1629 T2148 T2147 arg1Of survival,the
R1630 T2148 T2149 arg1Of survival,of
R1631 T2148 T2151 arg1Of survival,producing
R1632 T2150 T2149 arg2Of autoantibody-,of
R1633 T2153 T2151 arg2Of lymphocytes,producing
R1634 T2153 T2152 arg1Of lymphocytes,B
R1635 T2155 T2154 arg1Of is,","
R1636 T2155 T2156 arg1Of is,also
R1637 T2155 T2161 arg1Of is,and
R1638 T2157 T2155 arg2Of characteristic,is
R1639 T2157 T2158 arg1Of characteristic,for
R1640 T2159 T2158 arg2Of RA,for
R1641 T2161 T2160 arg1Of and,","
R1642 T2162 T2163 arg1Of antagonists,of
R1643 T2162 T2165 arg1Of antagonists,have
R1644 T2162 T2166 arg1Of antagonists,been
R1645 T2162 T2167 arg2Of antagonists,developed
R1646 T2164 T2163 arg2Of BAFF,of
R1647 T2167 T2161 arg2Of developed,and
R1648 T2167 T2165 arg2Of developed,have
R1649 T2167 T2166 arg2Of developed,been
R1650 T2167 T2168 modOf developed,to
R1651 T2169 T2168 arg1Of counter,to
R1652 T2170 T2169 arg2Of RA,counter
R1653 T2170 T2171 arg1Of RA,[
R1654 T2172 T2171 arg2Of 13,[
R1655 T2173 T2171 arg3Of ],[
R1656 T2179 T2176 arg1Of signalling,lymphotoxin
R1657 T2179 T2177 arg1Of signalling,β
R1658 T2179 T2178 arg1Of signalling,receptor
R1659 T2179 T2180 arg1Of signalling,has
R1660 T2179 T2181 arg1Of signalling,been
R1661 T2179 T2182 arg2Of signalling,implicated
R1662 T2182 T2174 arg1Of implicated,Finally
R1663 T2182 T2175 arg1Of implicated,","
R1664 T2182 T2180 arg2Of implicated,has
R1665 T2182 T2181 arg2Of implicated,been
R1666 T2182 T2183 arg1Of implicated,in
R1667 T2187 T2183 arg2Of formation,in
R1668 T2187 T2184 arg1Of formation,tertiary
R1669 T2187 T2185 arg1Of formation,lymphoid
R1670 T2187 T2186 arg1Of formation,organ
R1671 T2187 T2188 arg1Of formation,at
R1672 T2189 T2188 arg2Of sites,at
R1673 T2189 T2190 arg1Of sites,of
R1674 T2192 T2190 arg2Of inflammation,of
R1675 T2192 T2191 arg1Of inflammation,chronic
R1676 T2192 T2193 arg1Of inflammation,including
R1677 T2194 T2193 arg2Of RA,including
R1678 T2194 T2195 arg1Of RA,[
R1679 T2196 T2195 arg2Of 13,[
R1680 T2197 T2195 arg3Of ],[
R1681 T2199 T2198 arg1Of receptors,Toll-like
R1682 T2199 T2200 arg1Of receptors,(
R1683 T2199 T2203 arg1Of receptors,have
R1684 T2199 T2204 arg1Of receptors,been
R1685 T2199 T2205 arg2Of receptors,implicated
R1686 T2199 T2213 arg1Of receptors,are
R1687 T2201 T2200 arg2Of TLRs,(
R1688 T2202 T2200 arg3Of ),(
R1689 T2205 T2203 arg2Of implicated,have
R1690 T2205 T2204 arg2Of implicated,been
R1691 T2205 T2206 arg1Of implicated,in
R1692 T2205 T2212 arg1Of implicated,and
R1693 T2208 T2206 arg2Of variety,in
R1694 T2208 T2207 arg1Of variety,a
R1695 T2208 T2209 arg1Of variety,of
R1696 T2211 T2209 arg2Of diseases,of
R1697 T2211 T2210 arg1Of diseases,autoimmune
R1698 T2213 T2212 arg2Of are,and
R1699 T2215 T2213 arg2Of candidates,are
R17 T21 T20 arg1Of roles,crucial
R1700 T2215 T2214 arg1Of candidates,potential
R1701 T2215 T2216 arg1Of candidates,for
R1702 T2217 T2216 arg2Of inducing,for
R1703 T2217 T2220 arg1Of inducing,in
R1704 T2219 T2217 arg2Of inflammation,inducing
R1705 T2219 T2218 arg1Of inflammation,NF-κB-dependent
R1706 T2221 T2220 arg2Of RA,in
R1707 T2223 T2222 arg2Of addition,In
R1708 T2223 T2224 arg1Of addition,to
R1709 T2226 T2224 arg2Of ligands,to
R1710 T2226 T2225 arg1Of ligands,microbial
R1711 T2230 T2228 arg1Of number,an
R1712 T2230 T2229 arg1Of number,increasing
R1713 T2230 T2231 arg1Of number,of
R1714 T2230 T2234 arg1Of number,-
R1715 T2230 T2246 arg1Of number,have
R1716 T2230 T2247 arg1Of number,been
R1717 T2230 T2248 arg2Of number,reported
R1718 T2233 T2231 arg2Of ligands,of
R1719 T2233 T2232 arg1Of ligands,endogenous
R1720 T2236 T2234 arg2Of group,-
R1721 T2236 T2235 arg1Of group,a
R1722 T2236 T2237 arg1Of group,of
R1723 T2238 T2237 arg2Of proteins,of
R1724 T2238 T2239 arg2Of proteins,derived
R1725 T2239 T2240 arg1Of derived,from
R1726 T2242 T2241 arg1Of tissues,host
R1727 T2242 T2243 arg1Of tissues,and
R1728 T2243 T2240 arg2Of and,from
R1729 T2244 T2243 arg2Of cells,and
R1730 T2244 T2245 arg1Of cells,-
R1731 T2248 T2222 arg1Of reported,In
R1732 T2248 T2227 arg1Of reported,","
R1733 T2248 T2246 arg2Of reported,have
R1734 T2248 T2247 arg2Of reported,been
R1735 T2248 T2249 arg1Of reported,as
R1736 T2251 T2249 arg2Of activators,as
R1737 T2251 T2250 arg1Of activators,candidate
R1738 T2251 T2252 arg1Of activators,of
R1739 T2253 T2252 arg2Of TLRs,of
R1740 T2253 T2254 arg1Of TLRs,inducing
R1741 T2257 T2254 arg2Of inflammation,inducing
R1742 T2257 T2255 arg1Of inflammation,so-called
R1743 T2257 T2256 arg1Of inflammation,sterile
R1744 T2257 T2258 arg1Of inflammation,(
R1745 T2259 T2258 arg2Of reviewed,(
R1746 T2259 T2260 arg1Of reviewed,in
R1747 T2259 T2261 arg1Of reviewed,[
R1748 T2262 T2261 arg2Of "14,15",[
R1749 T2263 T2261 arg3Of ],[
R1750 T2264 T2258 arg3Of ),(
R1751 T2265 T2266 arg1Of TLRs,are
R1752 T2265 T2267 arg2Of TLRs,expressed
R1753 T2267 T2266 arg2Of expressed,are
R1754 T2267 T2268 arg1Of expressed,in
R1755 T2269 T2268 arg2Of RA,in
R1756 T2271 T2270 arg1Of tissues,synovial
R1757 T2271 T2272 arg1Of tissues,and
R1758 T2272 T2276 arg1Of and,are
R1759 T2272 T2277 arg1Of and,present
R1760 T2275 T2272 arg2Of ligands,and
R1761 T2275 T2273 arg1Of ligands,various
R1762 T2275 T2274 arg1Of ligands,endogenous
R1763 T2276 T2266 modOf are,are
R1764 T2277 T2276 arg2Of present,are
R1765 T2277 T2278 arg1Of present,within
R1766 T2281 T2278 arg2Of joints,within
R1767 T2281 T2279 arg1Of joints,the
R1768 T2281 T2280 arg1Of joints,inflamed
R1769 T2281 T2282 arg1Of joints,of
R1770 T2284 T2282 arg2Of patients,of
R1771 T2284 T2283 arg1Of patients,RA
R1772 T2288 T2287 arg1Of models,animal
R1773 T2288 T2289 arg1Of models,using
R1774 T2288 T2300 arg1Of models,identify
R1775 T2292 T2290 arg1Of mice,TLR
R1776 T2292 T2291 arg1Of mice,knockout
R1777 T2292 T2293 arg1Of mice,or
R1778 T2293 T2289 arg2Of or,using
R1779 T2294 T2293 arg2Of strategies,or
R1780 T2294 T2295 modOf strategies,to
R1781 T2296 T2295 arg1Of block,to
R1782 T2298 T2296 arg2Of signalling,block
R1783 T2298 T2297 arg1Of signalling,TLR
R1784 T2300 T2285 arg1Of identify,Moreover
R1785 T2300 T2286 arg1Of identify,","
R1786 T2300 T2299 arg1Of identify,clearly
R1787 T2300 T2303 arg1Of identify,as
R1788 T2302 T2300 arg2Of inflammation,identify
R1789 T2302 T2301 arg1Of inflammation,TLR-dependent
R1790 T2304 T2303 arg2Of being,as
R1791 T2304 T2306 arg1Of being,in
R1792 T2305 T2304 arg2Of important,being
R1793 T2308 T2306 arg2Of pathogenesis,in
R1794 T2308 T2307 arg1Of pathogenesis,the
R1795 T2308 T2309 arg1Of pathogenesis,of
R1796 T2311 T2309 arg2Of disease,of
R1797 T2311 T2310 arg1Of disease,the
R1798 T2317 T2312 arg1Of protein,High
R1799 T2317 T2313 arg1Of protein,mobility
R18 T24 T22 arg2Of regulation,in
R1800 T2317 T2314 arg1Of protein,group
R1801 T2317 T2315 arg1Of protein,box
R1802 T2317 T2316 arg1Of protein,chromosomal
R1803 T2317 T2318 arg1Of protein,1
R1804 T2317 T2319 arg1Of protein,(
R1805 T2317 T2322 arg1Of protein,","
R1806 T2317 T2342 arg1Of protein,is
R1807 T2320 T2319 arg2Of HMGB1,(
R1808 T2321 T2319 arg3Of ),(
R1809 T2325 T2324 arg1Of conserved,highly
R1810 T2327 T2322 arg2Of component,","
R1811 T2327 T2323 arg1Of component,a
R1812 T2327 T2325 arg1Of component,conserved
R1813 T2327 T2326 arg1Of component,chromatin
R1814 T2327 T2328 arg1Of component,that
R1815 T2327 T2329 arg1Of component,can
R1816 T2327 T2330 arg1Of component,be
R1817 T2327 T2332 arg2Of component,secreted
R1818 T2327 T2337 arg2Of component,released
R1819 T2332 T2335 arg1Of secreted,or
R1820 T2334 T2332 arg1Of macrophages,secreted
R1821 T2334 T2333 arg2Of macrophages,by
R1822 T2335 T2329 arg2Of or,can
R1823 T2335 T2330 arg2Of or,be
R1824 T2335 T2331 arg1Of or,actively
R1825 T2337 T2335 arg2Of released,or
R1826 T2337 T2336 arg1Of released,passively
R1827 T2340 T2337 arg1Of cells,released
R1828 T2340 T2338 arg2Of cells,by
R1829 T2340 T2339 arg1Of cells,necrotic
R1830 T2342 T2341 arg1Of is,","
R1831 T2343 T2342 arg2Of one,is
R1832 T2343 T2344 arg1Of one,of
R1833 T2348 T2346 arg1Of endogenous,most
R1834 T2348 T2347 arg1Of endogenous,putative
R1835 T2350 T2344 arg2Of ligands,of
R1836 T2350 T2345 arg1Of ligands,the
R1837 T2350 T2348 arg1Of ligands,endogenous
R1838 T2350 T2349 arg1Of ligands,TLR4
R1839 T2350 T2351 arg2Of ligands,involved
R1840 T2351 T2352 arg1Of involved,in
R1841 T2354 T2352 arg2Of pathology,in
R1842 T2354 T2353 arg1Of pathology,RA
R1843 T2355 T2356 arg1Of HMGB1,is
R1844 T2355 T2357 arg2Of HMGB1,increased
R1845 T2357 T2356 arg2Of increased,is
R1846 T2357 T2358 arg1Of increased,in
R1847 T2357 T2374 arg1Of increased,against
R1848 T2361 T2359 arg1Of tissue,RA
R1849 T2361 T2360 arg1Of tissue,synovial
R1850 T2361 T2362 arg1Of tissue,and
R1851 T2362 T2366 arg1Of and,or
R1852 T2365 T2362 arg2Of antibodies,and
R1853 T2365 T2363 arg1Of antibodies,HMGB1
R1854 T2365 T2364 arg1Of antibodies,neutralising
R1855 T2366 T2358 arg2Of or,in
R1856 T2370 T2366 arg2Of domain,or
R1857 T2370 T2367 arg1Of domain,the
R1858 T2370 T2368 arg1Of domain,antagonistic
R1859 T2370 T2369 arg1Of domain,BoxA
R1860 T2370 T2371 arg1Of domain,of
R1861 T2373 T2371 arg2Of protect,of
R1862 T2373 T2372 arg1Of protect,HMGB1
R1863 T2376 T2374 arg2Of arthritis,against
R1864 T2376 T2375 arg1Of arthritis,collagen-induced
R1865 T2376 T2377 arg1Of arthritis,in
R1866 T2378 T2377 arg2Of mice,in
R1867 T2378 T2379 arg1Of mice,[
R1868 T2380 T2379 arg2Of 16,[
R1869 T2381 T2379 arg3Of ],[
R1870 T2383 T2382 arg1Of protein,Myeloid-related
R1871 T2383 T2384 arg1Of protein,8
R1872 T2383 T2385 arg1Of protein,and
R1873 T2385 T2389 arg1Of and,","
R1874 T2385 T2403 arg1Of and,are
R1875 T2385 T2406 arg1Of and,present
R1876 T2385 T2413 arg1Of and,have
R1877 T2385 T2414 arg1Of and,been
R1878 T2385 T2415 arg2Of and,suggested
R1879 T2385 T2417 arg1Of and,be
R1880 T2385 T2418 arg2Of and,involved
R1881 T2387 T2385 arg2Of protein,and
R1882 T2387 T2386 arg1Of protein,myeloid-related
R1883 T2387 T2388 arg1Of protein,14
R1884 T2393 T2389 arg2Of molecules,","
R1885 T2393 T2390 arg1Of molecules,damage-associated
R1886 T2393 T2391 arg1Of molecules,molecular
R1887 T2393 T2392 arg1Of molecules,pattern
R1888 T2393 T2394 arg1Of molecules,belonging
R1889 T2394 T2395 arg1Of belonging,to
R1890 T2398 T2395 arg2Of family,to
R1891 T2398 T2396 arg1Of family,the
R1892 T2398 T2397 arg1Of family,S100
R1893 T2398 T2399 arg1Of family,of
R1894 T2401 T2399 arg2Of proteins,of
R1895 T2401 T2400 arg1Of proteins,calcium-binding
R1896 T2403 T2404 arg1Of are,also
R1897 T2403 T2412 arg1Of are,and
R1898 T2406 T2403 arg2Of present,are
R1899 T2406 T2405 arg1Of present,abundantly
R19 T24 T23 arg1Of regulation,the
R1900 T2406 T2407 arg1Of present,in
R1901 T2410 T2407 arg2Of fluid,in
R1902 T2410 T2408 arg1Of fluid,RA
R1903 T2410 T2409 arg1Of fluid,synovial
R1904 T2412 T2402 arg1Of and,","
R1905 T2412 T2411 arg1Of and,","
R1906 T2415 T2412 arg2Of suggested,and
R1907 T2415 T2413 arg2Of suggested,have
R1908 T2415 T2414 arg2Of suggested,been
R1909 T2418 T2415 arg3Of involved,suggested
R1910 T2418 T2416 arg1Of involved,to
R1911 T2418 T2417 arg2Of involved,be
R1912 T2418 T2419 arg1Of involved,in
R1913 T2418 T2423 arg1Of involved,in
R1914 T2422 T2419 arg2Of inflammation,in
R1915 T2422 T2420 arg1Of inflammation,TLR4-induced
R1916 T2422 T2421 arg1Of inflammation,chronic
R1917 T2424 T2423 arg2Of RA,in
R1918 T2424 T2425 arg1Of RA,[
R1919 T2426 T2425 arg2Of "17,18",[
R1920 T2427 T2425 arg3Of ],[
R1921 T2431 T2428 arg1Of ligands,Other
R1922 T2431 T2429 arg1Of ligands,endogenous
R1923 T2431 T2430 arg1Of ligands,TLR
R1924 T2431 T2432 arg1Of ligands,that
R1925 T2431 T2433 arg1Of ligands,may
R1926 T2431 T2434 arg1Of ligands,be
R1927 T2431 T2435 arg2Of ligands,involved
R1928 T2431 T2439 arg1Of ligands,are
R1929 T2435 T2433 arg2Of involved,may
R1930 T2435 T2434 arg2Of involved,be
R1931 T2435 T2436 arg1Of involved,in
R1932 T2438 T2436 arg2Of pathology,in
R1933 T2438 T2437 arg1Of pathology,RA
R1934 T2442 T2440 arg1Of components,extracellular
R1935 T2442 T2441 arg1Of components,matrix
R1936 T2442 T2444 arg1Of components,as
R1937 T2442 T2454 arg1Of components,and
R1938 T2444 T2443 arg1Of as,such
R1939 T2445 T2446 arg1Of fibrinogen,","
R1940 T2446 T2448 arg1Of ",",","
R1941 T2447 T2446 arg2Of fibronectin,","
R1942 T2448 T2450 arg1Of ",",","
R1943 T2449 T2448 arg2Of biglycan,","
R1944 T2450 T2444 arg2Of ",",as
R1945 T2452 T2450 arg2Of C,","
R1946 T2452 T2451 arg1Of C,tenascin
R1947 T2454 T2439 arg2Of and,are
R1948 T2454 T2453 arg1Of and,","
R1949 T2457 T2454 arg2Of fragments,and
R1950 T2457 T2455 arg1Of fragments,hyal-uronic
R1951 T2457 T2456 arg1Of fragments,acid
R1952 T2457 T2458 arg1Of fragments,(
R1953 T2459 T2458 arg2Of reviewed,(
R1954 T2459 T2460 arg1Of reviewed,in
R1955 T2459 T2461 arg1Of reviewed,[
R1956 T2462 T2461 arg2Of "14,15",[
R1957 T2463 T2461 arg3Of ],[
R1958 T2464 T2458 arg3Of ),(
R1959 T2468 T2467 arg1Of studies,these
R1960 T2468 T2469 arg1Of studies,suggest
R1961 T2469 T2465 arg1Of suggest,Together
R1962 T2469 T2466 arg1Of suggest,","
R1963 T2473 T2471 arg1Of ligands,several
R1964 T2473 T2472 arg1Of ligands,TLR
R1965 T2473 T2474 arg1Of ligands,in
R1966 T2473 T2479 arg1Of ligands,may
R1967 T2473 T2480 arg1Of ligands,contribute
R1968 T2478 T2474 arg2Of tissue,in
R1969 T2478 T2475 arg1Of tissue,the
R1970 T2478 T2476 arg1Of tissue,inflamed
R1971 T2478 T2477 arg1Of tissue,joint
R1972 T2480 T2469 arg2Of contribute,suggest
R1973 T2480 T2470 arg1Of contribute,that
R1974 T2480 T2479 arg2Of contribute,may
R1975 T2480 T2481 arg1Of contribute,to
R1976 T2483 T2482 arg1Of activation,NF-κB
R1977 T2483 T2484 arg1Of activation,and
R1978 T2484 T2481 arg2Of and,to
R1979 T2484 T2488 arg1Of and,in
R1980 T2487 T2484 arg2Of expression,and
R1981 T2487 T2485 arg1Of expression,inflammatory
R1982 T2487 T2486 arg1Of expression,gene
R1983 T2489 T2488 arg2Of RA,in
R2 T6 T7 arg1Of regulation,of
R20 T24 T25 arg1Of regulation,of
R21 T26 T27 arg1Of inflammation,and
R22 T27 T25 arg2Of and,of
R23 T29 T27 arg2Of responses,and
R233 T375 T374 arg1Of arthritis,Rheumatoid
R234 T375 T376 arg1Of arthritis,(
R235 T375 T379 arg1Of arthritis,is
R236 T375 T386 arg1Of arthritis,affecting
R237 T377 T376 arg2Of RA,(
R238 T378 T376 arg3Of ),(
R239 T379 T385 arg1Of is,","
R24 T29 T28 arg1Of responses,mmune
R240 T379 T386 modOf is,affecting
R241 T382 T381 arg1Of common,most
R242 T384 T379 arg2Of arthritis,is
R243 T384 T380 arg1Of arthritis,the
R244 T384 T382 arg1Of arthritis,common
R245 T384 T383 arg1Of arthritis,inflammatory
R246 T389 T387 arg1Of 1,up
R247 T389 T388 arg1Of 1,to
R248 T390 T386 arg2Of %,affecting
R249 T390 T389 arg1Of %,1
R25 T31 T30 arg1Of and,","
R250 T390 T391 arg1Of %,of
R251 T394 T391 arg2Of population,of
R252 T394 T392 arg1Of population,the
R253 T394 T393 arg1Of population,adult
R254 T395 T396 arg1Of RA,is
R255 T395 T397 arg2Of RA,characterised
R256 T397 T396 arg2Of characterised,is
R257 T401 T397 arg1Of polyarthritis,characterised
R258 T401 T398 arg2Of polyarthritis,by
R259 T401 T399 arg1Of polyarthritis,a
R26 T34 T32 arg1Of activity,inappropriate
R260 T401 T400 arg1Of polyarthritis,symmetrical
R261 T401 T402 arg2Of polyarthritis,in
R262 T401 T403 arg1Of polyarthritis,which
R263 T405 T404 arg1Of inflammation,chronic
R264 T405 T406 arg1Of inflammation,of
R265 T405 T408 arg1Of inflammation,is
R266 T405 T409 arg2Of inflammation,associated
R267 T407 T406 arg2Of joints,of
R268 T409 T402 arg1Of associated,in
R269 T409 T408 arg2Of associated,is
R27 T34 T33 arg1Of activity,NF-κB
R270 T409 T410 arg1Of associated,with
R271 T409 T418 arg1Of associated,","
R272 T409 T419 modOf associated,leading
R273 T413 T410 arg2Of destruction,with
R274 T413 T411 arg1Of destruction,a
R275 T413 T412 arg1Of destruction,progressive
R276 T413 T414 arg1Of destruction,of
R277 T415 T416 arg1Of cartilage,and
R278 T416 T414 arg2Of and,of
R279 T417 T416 arg2Of bone,and
R28 T34 T35 arg1Of activity,has
R280 T419 T420 arg1Of leading,to
R281 T422 T423 arg1Of decline,and
R282 T423 T420 arg2Of and,to
R283 T423 T421 arg1Of and,functional
R284 T424 T423 arg2Of disability,and
R285 T425 T426 arg1Of Infiltration,of
R286 T425 T435 arg1Of Infiltration,into
R287 T425 T439 arg1Of Infiltration,drives
R288 T425 T460 arg1Of Infiltration,infiltrating
R289 T427 T426 arg2Of cells,of
R29 T34 T36 arg1Of activity,been
R290 T427 T428 arg1Of cells,of
R291 T430 T431 arg1Of innate,and
R292 T432 T431 arg2Of adaptive,and
R293 T434 T428 arg2Of system,of
R294 T434 T429 arg1Of system,the
R295 T434 T430 arg1Of system,innate
R296 T434 T432 arg1Of system,adaptive
R297 T434 T433 arg1Of system,immune
R298 T438 T435 arg2Of space,into
R299 T438 T436 arg1Of space,the
R3 T6 T9 arg1Of regulation,and
R30 T34 T37 arg2Of activity,linked
R300 T438 T437 arg1Of space,joint
R301 T439 T459 arg1Of drives,by
R302 T442 T439 arg2Of production,drives
R303 T442 T440 arg1Of production,the
R3033 T4573 T4572 arg1Of proteins,NF-κB
R3034 T4573 T4574 arg1Of proteins,are
R3035 T4573 T4575 arg2Of proteins,sequestered
R3036 T4575 T4574 arg2Of sequestered,are
R3037 T4575 T4576 arg1Of sequestered,in
R3038 T4575 T4579 arg1Of sequestered,as
R3039 T4575 T4587 arg1Of sequestered,as
R304 T442 T441 arg1Of production,local
R3040 T4578 T4576 arg2Of cytoplasm,in
R3041 T4578 T4577 arg1Of cytoplasm,the
R3042 T4581 T4579 arg2Of complexes,as
R3043 T4581 T4580 arg1Of complexes,latent
R3044 T4584 T4575 arg1Of proteins,sequestered
R3045 T4584 T4582 arg2Of proteins,by
R3046 T4584 T4583 arg1Of proteins,inhibitory
R3047 T4584 T4585 arg2Of proteins,referred
R3048 T4585 T4586 arg1Of referred,to
R3049 T4588 T4587 arg2Of inhibitor,as
R305 T442 T443 arg1Of production,of
R3050 T4588 T4589 arg1Of inhibitor,of
R3051 T4592 T4591 arg2Of IκB,(
R3052 T4593 T4591 arg3Of ),(
R3053 T4594 T4589 arg2Of proteins,of
R3054 T4594 T4590 arg1Of proteins,NF-κB
R3055 T4594 T4591 arg1Of proteins,(
R3056 T4594 T4595 arg1Of proteins,","
R3057 T4594 T4596 arg1Of proteins,which
R3058 T4594 T4597 arg1Of proteins,prevent
R3059 T4600 T4598 arg1Of translocation,NF-κB
R306 T447 T448 arg1Of 1,and
R3060 T4600 T4599 arg1Of translocation,nuclear
R3061 T4600 T4601 arg1Of translocation,and
R3062 T4601 T4597 arg2Of and,prevent
R3063 T4603 T4601 arg2Of binding,and
R3064 T4603 T4602 arg1Of binding,DNA
R3065 T4603 T4604 arg1Of binding,[
R3066 T4605 T4604 arg2Of 19,[
R3067 T4606 T4604 arg3Of ],[
R3068 T4609 T4608 arg1Of majority,the
R3069 T4609 T4610 arg1Of majority,of
R307 T449 T448 arg2Of T-helper,and
R3070 T4609 T4635 arg1Of majority,serve
R3071 T4611 T4610 arg2Of IκBs,of
R3072 T4611 T4612 arg1Of IκBs,(
R3073 T4613 T4614 arg1Of IκBα,","
R3074 T4614 T4616 arg1Of ",",","
R3075 T4615 T4614 arg2Of IκBβ,","
R3076 T4616 T4618 arg1Of ",",","
R3077 T4617 T4616 arg2Of IκBε,","
R3078 T4618 T4612 arg2Of ",",(
R3079 T4618 T4626 arg1Of ",",","
R308 T452 T444 arg1Of cytokines,proinflammatory
R3080 T4619 T4618 arg2Of p105,","
R3081 T4619 T4620 arg1Of p105,(
R3082 T4622 T4620 arg2Of known,(
R3083 T4622 T4621 arg1Of known,also
R3084 T4622 T4623 arg1Of known,as
R3085 T4624 T4623 arg2Of NF-κB1,as
R3086 T4625 T4620 arg3Of ),(
R3087 T4627 T4626 arg2Of p100,","
R3088 T4627 T4628 arg1Of p100,(
R3089 T4630 T4628 arg2Of known,(
R309 T452 T445 arg1Of cytokines,T-helper
R3090 T4630 T4629 arg1Of known,also
R3091 T4630 T4631 arg1Of known,as
R3092 T4632 T4631 arg2Of NF-κB2,as
R3093 T4633 T4628 arg3Of ),(
R3094 T4634 T4612 arg3Of ),(
R3095 T4635 T4607 arg2Of serve,Whereas
R3096 T4635 T4636 arg1Of serve,as
R3097 T4637 T4636 arg2Of inhibitors,as
R3098 T4637 T4638 arg1Of inhibitors,of
R3099 T4639 T4638 arg2Of NF-κB,of
R31 T37 T31 arg2Of linked,and
R310 T452 T446 arg1Of cytokines,type
R3100 T4641 T4642 arg1Of IκBξ,and
R3101 T4642 T4645 arg1Of and,potentiate
R3102 T4643 T4642 arg2Of Bcl-3,and
R3103 T4645 T4644 arg1Of potentiate,instead
R3104 T4645 T4652 arg1Of potentiate,and
R3105 T4647 T4645 arg2Of transactivation,potentiate
R3106 T4647 T4646 arg1Of transactivation,NF-κB
R3107 T4647 T4648 arg1Of transactivation,in
R3108 T4651 T4648 arg2Of p100,in
R3109 T4651 T4649 arg1Of p100,the
R311 T452 T447 arg1Of cytokines,1
R3110 T4651 T4650 arg1Of p100,nucleus.
R3111 T4652 T4607 arg1Of and,Whereas
R3112 T4652 T4640 arg1Of and,","
R3113 T4653 T4654 arg1Of p105,are
R3114 T4654 T4652 arg2Of are,and
R3115 T4654 T4663 arg1Of are,","
R3116 T4654 T4664 arg1Of are,respectively
R3117 T4655 T4654 arg2Of precursors,are
R3118 T4655 T4656 arg1Of precursors,of
R3119 T4658 T4659 arg1Of p52,and
R312 T452 T449 arg1Of cytokines,T-helper
R3120 T4660 T4659 arg2Of p50,and
R3121 T4662 T4656 arg2Of subunits,of
R3122 T4662 T4657 arg1Of subunits,the
R3123 T4662 T4658 arg1Of subunits,p52
R3124 T4662 T4660 arg1Of subunits,p50
R3125 T4662 T4661 arg1Of subunits,NF-κB
R3126 T4665 T4666 arg1Of There,are
R3127 T4671 T4666 arg2Of pathways,are
R3128 T4671 T4667 arg1Of pathways,two
R3129 T4671 T4668 arg1Of pathways,unique
R313 T452 T450 arg1Of cytokines,type
R3130 T4671 T4669 arg1Of pathways,NF-κB
R3131 T4671 T4670 arg1Of pathways,signalling
R3132 T4671 T4672 arg1Of pathways,","
R3133 T4671 T4673 arg2Of pathways,termed
R3134 T4674 T4675 arg1Of canonical,(
R3135 T4674 T4679 arg1Of canonical,and
R3136 T4677 T4675 arg2Of classical,(
R3137 T4677 T4676 arg1Of classical,or
R3138 T4678 T4675 arg3Of ),(
R3139 T4680 T4681 arg1Of noncanonical,(
R314 T452 T451 arg1Of cytokines,17
R3140 T4680 T4682 arg1Of noncanonical,or
R3141 T4682 T4679 arg2Of or,and
R3142 T4685 T4682 arg2Of NF-κB,or
R3143 T4685 T4683 arg1Of NF-κB,alternative
R3144 T4685 T4684 arg1Of NF-κB,)
R3145 T4686 T4673 arg3Of pathways,termed
R3146 T4686 T4674 arg1Of pathways,canonical
R3147 T4686 T4680 arg1Of pathways,noncanonical
R3148 T4686 T4685 arg1Of pathways,NF-κB
R3149 T4690 T4687 arg1Of pathway,The
R315 T452 T453 arg1Of cytokines,","
R3150 T4690 T4688 arg1Of pathway,canonical
R3151 T4690 T4689 arg1Of pathway,NF-κB
R3152 T4690 T4691 arg1Of pathway,plays
R3153 T4690 T4702 arg1Of pathway,is
R3154 T4690 T4703 arg2Of pathway,triggered
R3155 T4691 T4695 arg1Of plays,in
R3156 T4691 T4701 arg1Of plays,and
R3157 T4694 T4691 arg2Of role,plays
R3158 T4694 T4692 arg1Of role,a
R3159 T4694 T4693 arg1Of role,major
R316 T453 T456 arg1Of ",",and
R3160 T4696 T4697 arg1Of innate,and
R3161 T4698 T4697 arg2Of adaptive,and
R3162 T4699 T4695 arg2Of immunity,in
R3163 T4699 T4696 arg1Of immunity,innate
R3164 T4699 T4698 arg1Of immunity,adaptive
R3165 T4701 T4700 arg1Of and,","
R3166 T4703 T4701 arg2Of triggered,and
R3167 T4703 T4702 arg2Of triggered,is
R3168 T4706 T4703 arg1Of stimuli,triggered
R3169 T4706 T4704 arg2Of stimuli,by
R317 T454 T453 arg2Of chemokines,","
R3170 T4706 T4705 arg1Of stimuli,many
R3171 T4706 T4707 arg1Of stimuli,including
R3172 T4709 T4708 arg1Of cytokines,proinflammatory
R3173 T4709 T4710 arg1Of cytokines,(
R3174 T4709 T4718 arg1Of cytokines,","
R3175 T4711 T4710 arg2Of for,(
R3176 T4712 T4713 arg1Of example,","
R3177 T4713 T4715 arg1Of ",",","
R3178 T4714 T4713 arg2Of TNF,","
R3179 T4715 T4711 arg2Of ",",for
R318 T456 T443 arg2Of and,of
R3180 T4716 T4715 arg2Of IL-1,","
R3181 T4717 T4710 arg3Of ),(
R3182 T4718 T4707 arg2Of ",",including
R3183 T4719 T4720 arg1Of antigens,","
R3184 T4720 T4723 arg1Of ",",and
R3185 T4721 T4720 arg2Of RANKL,","
R3186 T4723 T4718 arg2Of and,","
R3187 T4723 T4722 arg1Of and,","
R3188 T4725 T4723 arg2Of ligands,and
R3189 T4725 T4724 arg1Of ligands,TLR
R319 T456 T455 arg1Of and,","
R3190 T4727 T4726 arg1Of signalling,NF-κB
R3191 T4727 T4728 arg2Of signalling,initiated
R3192 T4727 T4732 arg1Of signalling,requires
R3193 T4731 T4728 arg1Of receptors,initiated
R3194 T4731 T4729 arg2Of receptors,by
R3195 T4731 T4730 arg1Of receptors,different
R3196 T4734 T4732 arg2Of formation,requires
R3197 T4734 T4733 arg1Of formation,the
R3198 T4734 T4735 arg1Of formation,of
R3199 T4734 T4759 arg1Of formation,","
R32 T37 T35 arg2Of linked,has
R320 T458 T456 arg2Of metalloproteinases,and
R3200 T4734 T4760 arg1Of formation,which
R3201 T4734 T4761 arg1Of formation,mediates
R3202 T4738 T4735 arg2Of interactions,of
R3203 T4738 T4736 arg1Of interactions,proximal
R3204 T4738 T4737 arg1Of interactions,protein-protein
R3205 T4738 T4739 arg1Of interactions,that
R3206 T4738 T4740 arg1Of interactions,are
R3207 T4738 T4743 arg1Of interactions,specific
R3208 T4738 T4747 arg1Of interactions,converge
R3209 T4740 T4741 arg1Of are,often
R321 T458 T457 arg1Of metalloproteinases,matrix
R3210 T4740 T4745 arg1Of are,but
R3211 T4743 T4740 arg2Of specific,are
R3212 T4743 T4742 arg1Of specific,receptor
R3213 T4745 T4744 arg1Of but,","
R3214 T4747 T4745 arg2Of converge,but
R3215 T4747 T4746 arg1Of converge,ultimately
R3216 T4747 T4748 arg1Of converge,in
R3217 T4750 T4748 arg2Of activation,in
R3218 T4750 T4749 arg1Of activation,the
R3219 T4750 T4751 arg1Of activation,of
R322 T460 T459 arg2Of infiltrating,by
R3220 T4754 T4753 arg1Of kinase,IκB
R3221 T4754 T4755 arg1Of kinase,(
R3222 T4756 T4755 arg2Of IKK,(
R3223 T4757 T4755 arg3Of ),(
R3224 T4758 T4751 arg2Of complex,of
R3225 T4758 T4752 arg1Of complex,the
R3226 T4758 T4754 arg1Of complex,kinase
R3227 T4762 T4761 arg2Of phosphorylation,mediates
R3228 T4762 T4763 arg1Of phosphorylation,of
R3229 T4767 T4763 arg2Of protein,of
R323 T461 T462 arg1Of monocytes,and
R3230 T4767 T4764 arg1Of protein,the
R3231 T4767 T4765 arg1Of protein,inhibitory
R3232 T4767 T4766 arg1Of protein,IκB
R3233 T4767 T4768 arg1Of protein,leading
R3234 T4768 T4769 arg1Of leading,to
R3235 T4768 T4777 arg1Of leading,[
R3236 T4771 T4772 arg1Of K48-polyubiquitination,and
R3237 T4772 T4769 arg2Of and,to
R3238 T4772 T4770 arg1Of and,its
R3239 T4772 T4774 arg1Of and,by
R324 T462 T460 arg2Of and,infiltrating
R3240 T4773 T4772 arg2Of degradation,and
R3241 T4776 T4774 arg2Of proteasome,by
R3242 T4776 T4775 arg1Of proteasome,the
R3243 T4778 T4777 arg2Of 20,[
R3244 T4779 T4777 arg3Of ],[
R3245 T4782 T4780 arg1Of complex,The
R3246 T4782 T4781 arg1Of complex,IKK
R3247 T4782 T4783 arg1Of complex,is
R3248 T4782 T4784 arg2Of complex,comprised
R3249 T4784 T4783 arg2Of comprised,is
R325 T464 T462 arg2Of cells,and
R3250 T4784 T4785 arg1Of comprised,of
R3251 T4784 T4816 arg1Of comprised,(
R3252 T4789 T4787 arg1Of subunits,two
R3253 T4789 T4788 arg1Of subunits,catalytic
R3254 T4790 T4791 arg1Of IKK1,and
R3255 T4791 T4786 arg1Of and,the
R3256 T4791 T4789 arg1Of and,subunits
R3257 T4791 T4793 arg1Of and,(
R3258 T4791 T4801 arg1Of and,and
R3259 T4792 T4791 arg2Of IKK2,and
R326 T464 T463 arg1Of cells,synovial
R3260 T4795 T4793 arg2Of known,(
R3261 T4795 T4794 arg1Of known,also
R3262 T4795 T4796 arg1Of known,as
R3263 T4797 T4798 arg1Of IKKα,and
R3264 T4798 T4796 arg2Of and,as
R3265 T4799 T4798 arg2Of IKKβ,and
R3266 T4800 T4793 arg3Of ),(
R3267 T4801 T4785 arg2Of and,of
R3268 T4807 T4801 arg2Of modulator,and
R3269 T4807 T4802 arg1Of modulator,the
R327 T465 T466 arg1Of Proliferation,of
R3270 T4807 T4803 arg1Of modulator,regulatory
R3271 T4807 T4804 arg1Of modulator,subunit
R3272 T4807 T4805 arg1Of modulator,NF-κB
R3273 T4807 T4806 arg1Of modulator,essential
R3274 T4807 T4808 arg1Of modulator,(
R3275 T4809 T4808 arg2Of NEMO,(
R3276 T4809 T4810 arg1Of NEMO,-
R3277 T4809 T4812 arg2Of NEMO,known
R3278 T4812 T4811 arg1Of known,also
R3279 T4812 T4813 arg1Of known,as
R328 T465 T469 arg1Of Proliferation,leads
R3280 T4814 T4813 arg2Of IKKγ,as
R3281 T4815 T4808 arg3Of ),(
R3282 T4817 T4816 arg2Of Figure,(
R3283 T4817 T4818 arg1Of Figure,1
R3284 T4819 T4816 arg3Of ),(
R3285 T4820 T4821 arg1Of Gene,targeting
R3286 T4820 T4823 arg1Of Gene,showed
R3287 T4822 T4821 arg2Of experiments,targeting
R3288 T4825 T4826 arg1Of IKK2,and
R3289 T4826 T4829 arg1Of and,but
R329 T468 T466 arg2Of fibroblasts,of
R3290 T4827 T4826 arg2Of NEMO,and
R3291 T4829 T4828 arg1Of but,","
R3292 T4829 T4830 arg1Of but,not
R3293 T4829 T4833 arg1Of but,are
R3294 T4829 T4834 arg2Of but,required
R3295 T4831 T4829 arg2Of IKK1,but
R3296 T4834 T4823 arg2Of required,showed
R3297 T4834 T4824 arg1Of required,that
R3298 T4834 T4832 arg1Of required,","
R3299 T4834 T4833 arg2Of required,are
R33 T37 T36 arg2Of linked,been
R330 T468 T467 arg1Of fibroblasts,synovial
R3300 T4834 T4835 arg1Of required,for
R3301 T4834 T4839 arg1Of required,[
R3302 T4838 T4835 arg2Of activation,for
R3303 T4838 T4836 arg1Of activation,canonical
R3304 T4838 T4837 arg1Of activation,NF-κB
R3305 T4840 T4839 arg2Of 21,[
R3306 T4841 T4839 arg3Of ],[
R3307 T4842 T4843 arg1Of One,of
R3308 T4842 T4850 arg1Of One,is
R3309 T4846 T4845 arg1Of studied,best
R331 T469 T470 arg1Of leads,to
R3310 T4849 T4843 arg2Of pathways,of
R3311 T4849 T4844 arg1Of pathways,the
R3312 T4849 T4846 arg1Of pathways,studied
R3313 T4849 T4847 arg1Of pathways,NF-κB
R3314 T4849 T4848 arg1Of pathways,signalling
R3315 T4853 T4850 arg2Of pathway,is
R3316 T4853 T4851 arg1Of pathway,the
R3317 T4853 T4852 arg1Of pathway,TNF
R3318 T4855 T4854 arg1Of stimulation,TNF
R3319 T4855 T4856 arg1Of stimulation,results
R332 T472 T470 arg2Of formation,to
R3320 T4856 T4857 arg1Of results,in
R3321 T4859 T4860 arg1Of recruitment,of
R3322 T4859 T4870 arg1Of recruitment,of
R3323 T4859 T4878 arg1Of recruitment,","
R3324 T4859 T4879 arg1Of recruitment,which
R3325 T4859 T4880 arg1Of recruitment,function
R3326 T4859 T4896 arg1Of recruitment,and
R3327 T4860 T4869 arg1Of of,and
R3328 T4864 T4861 arg1Of domain,TNF
R3329 T4864 T4862 arg1Of domain,receptor-1-associated
R333 T472 T471 arg1Of formation,the
R3330 T4864 T4863 arg1Of domain,death
R3331 T4864 T4865 arg1Of domain,(
R3332 T4866 T4865 arg2Of TRADD,(
R3333 T4867 T4865 arg3Of ),(
R3334 T4868 T4860 arg2Of protein,of
R3335 T4868 T4864 arg1Of protein,domain
R3336 T4870 T4869 arg2Of of,and
R3337 T4873 T4870 arg2Of protein,of
R3338 T4873 T4871 arg1Of protein,receptor
R3339 T4873 T4872 arg1Of protein,interacting
R334 T472 T473 arg1Of formation,of
R3340 T4873 T4874 arg1Of protein,1
R3341 T4873 T4875 arg1Of protein,(
R3342 T4876 T4875 arg2Of RIP1,(
R3343 T4877 T4875 arg3Of ),(
R3344 T4880 T4881 arg1Of function,as
R3345 T4883 T4881 arg2Of proteins,as
R3346 T4883 T4882 arg1Of proteins,adaptor
R3347 T4883 T4884 arg1Of proteins,for
R3348 T4891 T4884 arg2Of factor,for
R3349 T4891 T4885 arg1Of factor,the
R335 T475 T473 arg2Of tissue,of
R3350 T4891 T4886 arg1Of factor,E3
R3351 T4891 T4887 arg1Of factor,ubiquitin
R3352 T4891 T4888 arg1Of factor,ligases
R3353 T4891 T4889 arg1Of factor,TNF
R3354 T4891 T4890 arg1Of factor,receptor-associated
R3355 T4891 T4892 arg1Of factor,(
R3356 T4891 T4895 arg1Of factor,2
R3357 T4893 T4892 arg2Of TRAF,(
R3358 T4894 T4892 arg3Of ),(
R3359 T4896 T4857 arg2Of and,in
R336 T475 T474 arg1Of tissue,pannus
R3360 T4896 T4858 arg1Of and,the
R3361 T4897 T4896 arg2Of TRAF5,and
R3362 T4897 T4898 arg1Of TRAF5,","
R3363 T4897 T4899 arg1Of TRAF5,which
R3364 T4897 T4902 arg1Of TRAF5,bind
R3365 T4901 T4900 arg2Of turn,in
R3366 T4902 T4900 arg1Of bind,in
R3367 T4908 T4902 arg2Of inhibitor,bind
R3368 T4908 T4903 arg1Of inhibitor,the
R3369 T4908 T4904 arg1Of inhibitor,E3
R337 T475 T476 arg1Of tissue,","
R3370 T4908 T4905 arg1Of inhibitor,ubiquitin
R3371 T4908 T4906 arg1Of inhibitor,ligases
R3372 T4908 T4907 arg1Of inhibitor,cellular
R3373 T4908 T4909 arg1Of inhibitor,of
R3374 T4910 T4911 arg1Of apoptosis,(
R3375 T4910 T4914 arg1Of apoptosis,1
R3376 T4910 T4915 arg1Of apoptosis,and
R3377 T4912 T4911 arg2Of cIAP,(
R3378 T4913 T4911 arg3Of ),(
R3379 T4915 T4909 arg2Of and,of
R338 T475 T477 arg1Of tissue,which
R3380 T4916 T4915 arg2Of cIAP2,and
R3381 T4916 T4917 arg1Of cIAP2,(
R3382 T4918 T4917 arg2Of Figure,(
R3383 T4918 T4919 arg1Of Figure,1
R3384 T4920 T4917 arg3Of ),(
R3385 T4923 T4921 arg2Of stimulation,On
R3386 T4923 T4922 arg1Of stimulation,TNF
R3387 T4925 T4926 arg1Of TNF-receptor,bound
R3388 T4926 T4921 arg1Of bound,On
R3389 T4926 T4924 arg1Of bound,","
R339 T475 T478 arg1Of tissue,invades
R3390 T4927 T4928 arg1Of RIP1,is
R3391 T4927 T4930 arg2Of RIP1,modified
R3392 T4930 T4926 arg2Of modified,bound
R3393 T4930 T4928 arg2Of modified,is
R3394 T4930 T4929 arg1Of modified,rapidly
R3395 T4934 T4930 arg1Of chains,modified
R3396 T4934 T4931 arg2Of chains,by
R3397 T4934 T4932 arg1Of chains,K63-linked
R3398 T4934 T4933 arg1Of chains,polyubiquitin
R3399 T4935 T4936 arg1Of TRAF2/5,and
R34 T37 T38 arg1Of linked,with
R340 T475 T480 arg1Of tissue,degrades
R3400 T4936 T4938 arg1Of and,are
R3401 T4937 T4936 arg2Of cIAP1/2,and
R3402 T4938 T4945 arg1Of are,but
R3403 T4940 T4938 arg2Of candidates,are
R3404 T4940 T4939 arg1Of candidates,good
R3405 T4940 T4941 arg1Of candidates,for
R3406 T4943 T4941 arg2Of ubiquitination,for
R3407 T4943 T4942 arg1Of ubiquitination,RIP1
R3408 T4945 T4944 arg1Of but,","
R3409 T4948 T4946 arg1Of role,the
R341 T478 T479 arg1Of invades,and
R3410 T4948 T4947 arg1Of role,specific
R3411 T4948 T4949 arg1Of role,of
R3412 T4948 T4951 arg1Of role,is
R3413 T4948 T4953 arg1Of role,unclear
R3414 T4950 T4949 arg2Of each,of
R3415 T4951 T4945 arg2Of is,but
R3416 T4951 T4952 arg1Of is,still
R3417 T4953 T4951 arg2Of unclear,is
R3418 T4956 T4954 arg1Of chains,The
R3419 T4956 T4955 arg1Of chains,polyubiquitin
R342 T480 T479 arg2Of degrades,and
R3420 T4956 T4957 arg1Of chains,on
R3421 T4956 T4959 arg1Of chains,are
R3422 T4956 T4960 arg2Of chains,believed
R3423 T4956 T4962 arg1Of chains,create
R3424 T4958 T4957 arg2Of RIP1,on
R3425 T4960 T4959 arg2Of believed,are
R3426 T4962 T4960 arg3Of create,believed
R3427 T4962 T4961 arg1Of create,to
R3428 T4964 T4962 arg2Of scaffold,create
R3429 T4964 T4963 arg1Of scaffold,a
R343 T482 T481 arg1Of cartilage,articular
R3430 T4964 T4965 modOf scaffold,to
R3431 T4966 T4965 arg1Of recruit,to
R3432 T4966 T4979 arg1Of recruit,","
R3433 T4966 T4980 arg1Of recruit,respectively
R3434 T4968 T4969 arg1Of IKK,and
R3435 T4970 T4969 arg2Of TAK1,and
R3436 T4971 T4966 arg2Of complex,recruit
R3437 T4971 T4967 arg1Of complex,the
R3438 T4971 T4968 arg1Of complex,IKK
R3439 T4971 T4970 arg1Of complex,TAK1
R344 T482 T483 arg1Of cartilage,and
R3440 T4971 T4972 arg1Of complex,via
R3441 T4975 T4973 arg1Of proteins,the
R3442 T4975 T4974 arg1Of proteins,ubiquitin-binding
R3443 T4976 T4977 arg1Of NEMO,and
R3444 T4977 T4972 arg2Of and,via
R3445 T4977 T4975 arg1Of and,proteins
R3446 T4978 T4977 arg2Of TAB1/2,and
R3447 T4983 T4981 arg1Of identification,The
R3448 T4983 T4982 arg1Of identification,recent
R3449 T4983 T4984 arg1Of identification,of
R345 T483 T478 arg2Of and,invades
R3450 T4983 T5004 arg1Of identification,adds
R3451 T4989 T4984 arg2Of complex,of
R3452 T4989 T4985 arg1Of complex,a
R3453 T4989 T4986 arg1Of complex,distinct
R3454 T4989 T4987 arg1Of complex,E2/E3
R3455 T4989 T4988 arg1Of complex,enzyme
R3456 T4989 T4990 arg1Of complex,that
R3457 T4989 T4991 arg1Of complex,modifies
R3458 T4989 T4998 arg1Of complex,is
R3459 T4989 T4999 arg1Of complex,essential
R346 T483 T480 arg2Of and,degrades
R3460 T4991 T4997 arg1Of modifies,and
R3461 T4992 T4991 arg2Of NEMO,modifies
R3462 T4992 T4993 arg1Of NEMO,with
R3463 T4996 T4993 arg2Of chains,with
R3464 T4996 T4994 arg1Of chains,linear
R3465 T4996 T4995 arg1Of chains,polyubiquitin
R3466 T4998 T4997 arg2Of is,and
R3467 T4999 T4998 arg2Of essential,is
R3468 T4999 T5000 arg1Of essential,for
R3469 T5003 T5000 arg2Of signalling,for
R347 T485 T483 arg2Of bone,and
R3470 T5003 T5001 arg1Of signalling,TNF-activated
R3471 T5003 T5002 arg1Of signalling,NF-κB
R3472 T5006 T5004 arg2Of complexity,adds
R3473 T5006 T5005 arg1Of complexity,further
R3474 T5006 T5007 arg1Of complexity,[
R3475 T5008 T5007 arg2Of 22,[
R3476 T5009 T5007 arg3Of ],[
R3477 T5012 T5010 arg1Of role,The
R3478 T5012 T5011 arg1Of role,exact
R3479 T5012 T5013 arg1Of role,of
R348 T485 T484 arg1Of bone,subchondral
R3480 T5012 T5017 arg1Of role,remains
R3481 T5012 T5018 arg1Of role,unclear
R3482 T5016 T5013 arg2Of chains,of
R3483 T5016 T5014 arg1Of chains,protein-anchored
R3484 T5016 T5015 arg1Of chains,polyubiquitin
R3485 T5017 T5019 arg1Of remains,","
R3486 T5017 T5020 arg1Of remains,as
R3487 T5018 T5017 arg2Of unclear,remains
R3488 T5021 T5022 arg1Of it,was
R3489 T5021 T5024 arg2Of it,suggested
R349 T487 T486 arg1Of aetiology,The
R3490 T5024 T5020 arg2Of suggested,as
R3491 T5024 T5022 arg2Of suggested,was
R3492 T5024 T5023 arg1Of suggested,recently
R3493 T5028 T5026 arg1Of chains,unanchored
R3494 T5028 T5027 arg1Of chains,polyubiquitin
R3495 T5028 T5029 arg1Of chains,can
R3496 T5028 T5031 arg1Of chains,activate
R3497 T5031 T5024 arg3Of activate,suggested
R3498 T5031 T5025 arg1Of activate,that
R3499 T5031 T5029 arg2Of activate,can
R35 T40 T41 arg1Of autoimmune,and
R350 T487 T488 arg1Of aetiology,of
R3500 T5031 T5030 arg1Of activate,directly
R3501 T5031 T5035 arg1Of activate,[
R3502 T5034 T5031 arg2Of complex,activate
R3503 T5034 T5032 arg1Of complex,the
R3504 T5034 T5033 arg1Of complex,TAK1
R3505 T5036 T5035 arg2Of 23,[
R3506 T5037 T5035 arg3Of ],[
R3507 T5040 T5038 arg1Of principles,Similar
R3508 T5040 T5039 arg1Of principles,signalling
R3509 T5040 T5041 arg1Of principles,apply
R351 T487 T490 arg1Of aetiology,is
R3510 T5041 T5042 arg1Of apply,to
R3511 T5044 T5042 arg2Of receptors,to
R3512 T5044 T5043 arg1Of receptors,other
R3513 T5046 T5045 arg2Of example,For
R3514 T5049 T5048 arg1Of stimulation,TLR4
R3515 T5049 T5050 arg1Of stimulation,by
R3516 T5049 T5052 arg1Of stimulation,induces
R3517 T5051 T5050 arg2Of lipopolysaccharide,by
R3518 T5052 T5045 arg1Of induces,For
R3519 T5052 T5047 arg1Of induces,","
R352 T487 T493 arg2Of aetiology,understood
R3520 T5054 T5052 arg2Of recruitment,induces
R3521 T5054 T5053 arg1Of recruitment,the
R3522 T5054 T5055 arg1Of recruitment,of
R3523 T5059 T5056 arg1Of protein,Toll/IL-1
R3524 T5059 T5057 arg1Of protein,receptor
R3525 T5059 T5058 arg1Of protein,adaptor
R3526 T5059 T5060 arg1Of protein,(
R3527 T5059 T5067 arg1Of protein,and
R3528 T5062 T5060 arg2Of referred,(
R3529 T5062 T5061 arg1Of referred,also
R353 T489 T488 arg2Of RA,of
R3530 T5062 T5063 arg1Of referred,to
R3531 T5062 T5064 arg1Of referred,as
R3532 T5065 T5064 arg2Of Mal,as
R3533 T5066 T5060 arg3Of ),(
R3534 T5067 T5055 arg2Of and,of
R3535 T5067 T5074 arg1Of and,","
R3536 T5067 T5075 arg1Of and,which
R3537 T5067 T5078 arg1Of and,serve
R3538 T5067 T5080 arg1Of and,bridging
R3539 T5070 T5067 arg2Of molecule,and
R354 T493 T490 arg2Of understood,is
R3540 T5070 T5068 arg1Of molecule,TRIF-related
R3541 T5070 T5069 arg1Of molecule,adaptor
R3542 T5070 T5071 arg1Of molecule,(
R3543 T5072 T5071 arg2Of TRAM,(
R3544 T5073 T5071 arg3Of ),(
R3545 T5077 T5076 arg1Of probably,most
R3546 T5078 T5077 arg1Of serve,probably
R3547 T5078 T5079 arg1Of serve,as
R3548 T5080 T5079 arg2Of bridging,as
R3549 T5081 T5080 arg2Of factors,bridging
R355 T493 T491 arg1Of understood,still
R3550 T5081 T5083 arg1Of factors,recruit
R3551 T5083 T5080 arg3Of recruit,bridging
R3552 T5083 T5082 arg1Of recruit,to
R3553 T5083 T5101 arg1Of recruit,","
R3554 T5083 T5102 arg1Of recruit,respectively
R3555 T5086 T5084 arg1Of primary,myeloid
R3556 T5086 T5085 arg1Of primary,differentiation
R3557 T5088 T5087 arg1Of gene,response
R3558 T5088 T5089 arg1Of gene,88
R3559 T5088 T5090 arg1Of gene,(
R356 T493 T492 arg1Of understood,not
R3560 T5088 T5093 arg1Of gene,and
R3561 T5091 T5090 arg2Of MyD88,(
R3562 T5092 T5090 arg3Of ),(
R3563 T5093 T5083 arg2Of and,recruit
R3564 T5093 T5086 arg1Of and,primary
R3565 T5097 T5093 arg2Of IFNβ,and
R3566 T5097 T5094 arg1Of IFNβ,TIR
R3567 T5097 T5095 arg1Of IFNβ,domain-containing
R3568 T5097 T5096 arg1Of IFNβ,adaptor-inducing
R3569 T5097 T5098 arg1Of IFNβ,(
R357 T493 T495 arg1Of understood,but
R3570 T5099 T5098 arg2Of TRIF,(
R3571 T5100 T5098 arg3Of ),(
R3572 T5103 T5106 arg1Of MyD88,recruits
R3573 T5105 T5104 arg2Of turn,in
R3574 T5106 T5104 arg1Of recruits,in
R3575 T5106 T5118 arg1Of recruits,","
R3576 T5106 T5119 modOf recruits,leading
R3577 T5106 T5126 arg1Of recruits,[
R3578 T5107 T5106 arg2Of members,recruits
R3579 T5107 T5108 arg1Of members,of
R358 T495 T494 arg1Of but,","
R3580 T5113 T5112 arg2Of IRAK,(
R3581 T5114 T5112 arg3Of ),(
R3582 T5115 T5116 arg1Of family,and
R3583 T5116 T5108 arg2Of and,of
R3584 T5116 T5109 arg1Of and,the
R3585 T5116 T5110 arg1Of and,IL-1R-associated
R3586 T5116 T5111 arg1Of and,kinase
R3587 T5116 T5112 arg1Of and,(
R3588 T5117 T5116 arg2Of TRAF6,and
R3589 T5119 T5120 arg1Of leading,to
R359 T496 T497 arg1Of it,is
R3590 T5121 T5122 arg1Of oligomerisation,and
R3591 T5122 T5120 arg2Of and,to
R3592 T5122 T5124 arg1Of and,of
R3593 T5123 T5122 arg2Of selfubiquitination,and
R3594 T5125 T5124 arg2Of TRAF6,of
R3595 T5127 T5126 arg2Of 24,[
R3596 T5128 T5126 arg3Of ],[
R3597 T5129 T5131 arg1Of TRIF,recruits
R3598 T5131 T5130 arg1Of recruits,also
R3599 T5131 T5141 arg1Of recruits,via
R36 T42 T41 arg2Of inflammatory,and
R360 T496 T499 arg2Of it,accepted
R3600 T5132 T5133 arg1Of TRAF6,[
R3601 T5132 T5136 arg1Of TRAF6,and
R3602 T5134 T5133 arg2Of 25,[
R3603 T5135 T5133 arg3Of ],[
R3604 T5136 T5131 arg2Of and,recruits
R3605 T5137 T5136 arg2Of RIP1,and
R3606 T5137 T5138 arg1Of RIP1,[
R3607 T5139 T5138 arg2Of 26,[
R3608 T5140 T5138 arg3Of ],[
R3609 T5144 T5141 arg2Of interaction,via
R361 T499 T495 arg2Of accepted,but
R3610 T5144 T5142 arg1Of interaction,a
R3611 T5144 T5143 arg1Of interaction,direct
R3612 T5146 T5145 arg1Of pathways,Both
R3613 T5146 T5148 arg1Of pathways,activate
R3614 T5148 T5147 arg1Of activate,then
R3615 T5148 T5152 arg1Of activate,in
R3616 T5149 T5150 arg1Of TAK1,and
R3617 T5150 T5148 arg2Of and,activate
R3618 T5151 T5150 arg2Of IKK,and
R3619 T5155 T5152 arg2Of manner,in
R362 T499 T497 arg2Of accepted,is
R3620 T5155 T5153 arg1Of manner,a
R3621 T5155 T5154 arg1Of manner,ubiquitination-dependent
R3622 T5155 T5156 arg1Of manner,similar
R3623 T5156 T5157 arg1Of similar,to
R3624 T5160 T5157 arg2Of pathway,to
R3625 T5160 T5158 arg1Of pathway,the
R3626 T5160 T5159 arg1Of pathway,TNF
R3627 T5160 T5161 arg1Of pathway,(
R3628 T5162 T5161 arg2Of Figure,(
R3629 T5162 T5163 arg1Of Figure,1
R363 T499 T498 arg1Of accepted,well
R3630 T5164 T5161 arg3Of ),(
R3631 T5168 T5165 arg1Of pathway,The
R3632 T5168 T5166 arg1Of pathway,noncanonical
R3633 T5168 T5167 arg1Of pathway,NF-κB
R3634 T5168 T5169 arg1Of pathway,can
R3635 T5168 T5170 arg1Of pathway,be
R3636 T5168 T5171 arg2Of pathway,activated
R3637 T5171 T5169 arg2Of activated,can
R3638 T5171 T5170 arg2Of activated,be
R3639 T5171 T5172 arg1Of activated,by
R364 T501 T502 arg1Of activation,of
R3640 T5176 T5173 arg1Of receptor,the
R3641 T5176 T5174 arg1Of receptor,lymphotoxin
R3642 T5176 T5175 arg1Of receptor,β
R3643 T5176 T5177 arg1Of receptor,","
R3644 T5176 T5180 arg1Of receptor,","
R3645 T5179 T5177 arg2Of receptor,","
R3646 T5179 T5178 arg1Of receptor,BAFF
R3647 T5180 T5183 arg1Of ",",and
R3648 T5181 T5180 arg2Of CD40,","
R3649 T5183 T5172 arg2Of and,by
R365 T501 T506 arg1Of activation,plays
R3650 T5183 T5182 arg1Of and,","
R3651 T5184 T5183 arg2Of RANK,and
R3652 T5184 T5185 arg1Of RANK,(
R3653 T5186 T5185 arg2Of Figure,(
R3654 T5186 T5187 arg1Of Figure,2
R3655 T5188 T5185 arg3Of ),(
R3656 T5191 T5189 arg2Of pathway,In
R3657 T5191 T5190 arg1Of pathway,this
R3658 T5193 T5194 arg1Of p100,is
R3659 T5193 T5195 arg2Of p100,processed
R366 T505 T502 arg2Of expression,of
R3660 T5195 T5194 arg2Of processed,is
R3661 T5195 T5226 arg1Of processed,and
R3662 T5198 T5199 arg1Of proteasome,to
R3663 T5198 T5201 arg1Of proteasome,","
R3664 T5198 T5202 arg1Of proteasome,which
R3665 T5198 T5209 arg1Of proteasome,regulates
R3666 T5198 T5220 arg1Of proteasome,","
R3667 T5200 T5199 arg2Of p52,to
R3668 T5203 T5204 arg1Of together,with
R3669 T5208 T5204 arg2Of subunit,with
R367 T505 T503 arg1Of expression,NF-κB-dependent
R3670 T5208 T5205 arg1Of subunit,the
R3671 T5208 T5206 arg1Of subunit,RelB
R3672 T5208 T5207 arg1Of subunit,NF-κB
R3673 T5209 T5203 arg1Of regulates,together
R3674 T5212 T5209 arg2Of set,regulates
R3675 T5212 T5210 arg1Of set,a
R3676 T5212 T5211 arg1Of set,distinct
R3677 T5212 T5213 arg1Of set,of
R3678 T5215 T5213 arg2Of genes,of
R3679 T5215 T5214 arg1Of genes,target
R368 T505 T504 arg1Of expression,gene
R3680 T5215 T5216 arg1Of genes,that
R3681 T5215 T5217 arg1Of genes,control
R3682 T5219 T5217 arg2Of development,control
R3683 T5219 T5218 arg1Of development,B-cell
R3684 T5220 T5195 arg1Of ",",processed
R3685 T5220 T5196 arg2Of ",",by
R3686 T5220 T5197 arg1Of ",",the
R3687 T5224 T5220 arg2Of development,","
R3688 T5224 T5221 arg1Of development,secondary
R3689 T5224 T5222 arg1Of development,lymphoid
R369 T506 T499 arg3Of plays,accepted
R3690 T5224 T5223 arg1Of development,organ
R3691 T5226 T5189 arg1Of and,In
R3692 T5226 T5192 arg1Of and,","
R3693 T5226 T5225 arg1Of and,","
R3694 T5229 T5228 arg2Of 27,[
R3695 T5230 T5228 arg3Of ],[
R3696 T5232 T5231 arg1Of noncanonical,The
R3697 T5234 T5227 arg1Of pathway,osteoclastogenesis
R3698 T5234 T5228 arg1Of pathway,[
R3699 T5234 T5232 arg1Of pathway,noncanonical
R37 T43 T38 arg2Of diseases,with
R370 T506 T500 arg1Of plays,that
R3700 T5234 T5233 arg1Of pathway,NF-κB
R3701 T5234 T5235 arg1Of pathway,is
R3702 T5234 T5237 arg1Of pathway,dependent
R3703 T5235 T5226 arg2Of is,and
R3704 T5237 T5235 arg2Of dependent,is
R3705 T5237 T5236 arg1Of dependent,strictly
R3706 T5237 T5238 arg1Of dependent,on
R3707 T5239 T5238 arg2Of IKK1,on
R3708 T5239 T5240 arg1Of IKK1,","
R3709 T5239 T5241 arg1Of IKK1,which
R371 T506 T510 arg1Of plays,in
R3710 T5239 T5242 arg1Of IKK1,is
R3711 T5239 T5243 arg2Of IKK1,activated
R3712 T5243 T5242 arg2Of activated,is
R3713 T5243 T5244 arg1Of activated,upon
R3714 T5245 T5244 arg2Of phosphorylation,upon
R3715 T5245 T5246 arg1Of phosphorylation,by
R3716 T5247 T5246 arg2Of NF-κB,by
R3717 T5247 T5248 arg1Of NF-κB,inducing
R3718 T5249 T5248 arg2Of kinase,inducing
R3719 T5249 T5250 arg1Of kinase,(
R372 T509 T506 arg2Of role,plays
R3720 T5251 T5250 arg2Of NIK,(
R3721 T5252 T5250 arg3Of ),(
R3722 T5253 T5254 arg1Of NIK,is
R3723 T5253 T5256 arg2Of NIK,regulated
R3724 T5253 T5262 arg1Of NIK,is
R3725 T5253 T5263 arg1Of NIK,present
R3726 T5256 T5254 arg2Of regulated,is
R3727 T5256 T5255 arg1Of regulated,predominantly
R3728 T5256 T5257 arg1Of regulated,at
R3729 T5256 T5261 arg1Of regulated,and
R373 T509 T507 arg1Of role,a
R3730 T5260 T5257 arg2Of level,at
R3731 T5260 T5258 arg1Of level,the
R3732 T5260 T5259 arg1Of level,post-translational
R3733 T5262 T5261 arg2Of is,and
R3734 T5263 T5262 arg2Of present,is
R3735 T5263 T5264 arg1Of present,at
R3736 T5263 T5268 arg1Of present,in
R3737 T5266 T5265 arg1Of low,extremely
R3738 T5267 T5264 arg2Of levels,at
R3739 T5267 T5266 arg1Of levels,low
R374 T509 T508 arg1Of role,key
R3740 T5271 T5268 arg2Of types,in
R3741 T5271 T5269 arg1Of types,most
R3742 T5271 T5270 arg1Of types,cell
R3743 T5274 T5272 arg2Of cells,In
R3744 T5274 T5273 arg1Of cells,unstimulated
R3745 T5276 T5277 arg1Of NIK,occurs
R3746 T5277 T5272 arg1Of occurs,In
R3747 T5277 T5275 arg1Of occurs,","
R3748 T5277 T5278 arg1Of occurs,in
R3749 T5277 T5293 arg1Of occurs,","
R375 T512 T510 arg2Of development,in
R3750 T5277 T5294 modOf occurs,leading
R3751 T5281 T5278 arg2Of complex,in
R3752 T5281 T5279 arg1Of complex,a
R3753 T5281 T5280 arg1Of complex,cytoplasmic
R3754 T5281 T5282 arg1Of complex,with
R3755 T5283 T5284 arg1Of TRAF2,","
R3756 T5284 T5287 arg1Of ",",and
R3757 T5285 T5284 arg2Of TRAF3,","
R3758 T5287 T5282 arg2Of and,with
R3759 T5287 T5286 arg1Of and,","
R376 T512 T511 arg1Of development,the
R3760 T5287 T5289 arg1Of and,","
R3761 T5287 T5290 arg1Of and,which
R3762 T5287 T5291 arg1Of and,K48-polyubiquitinates
R3763 T5288 T5287 arg2Of cIAP1/2,and
R3764 T5292 T5291 arg2Of NIK,K48-polyubiquitinates
R3765 T5294 T5295 arg1Of leading,to
R3766 T5298 T5295 arg2Of degradation,to
R3767 T5298 T5296 arg1Of degradation,its
R3768 T5298 T5297 arg1Of degradation,continuous
R3769 T5298 T5299 arg1Of degradation,by
R377 T512 T513 arg1Of development,of
R3770 T5301 T5299 arg2Of proteasome,by
R3771 T5301 T5300 arg1Of proteasome,the
R3772 T5303 T5302 arg1Of ligation,Receptor
R3773 T5303 T5304 arg1Of ligation,has
R3774 T5303 T5305 arg1Of ligation,been
R3775 T5303 T5306 arg2Of ligation,shown
R3776 T5306 T5304 arg2Of shown,has
R3777 T5306 T5305 arg2Of shown,been
R3778 T5306 T5309 modOf shown,to
R3779 T5306 T5324 modOf shown,to
R378 T514 T515 arg1Of RA,and
R3780 T5308 T5307 arg1Of only,not
R3781 T5310 T5309 arg1Of remove,to
R3782 T5310 T5315 arg1Of remove,by
R3783 T5310 T5322 arg1Of remove,but
R3784 T5311 T5310 arg2Of TRAF3,remove
R3785 T5311 T5312 arg1Of TRAF3,from
R3786 T5314 T5312 arg2Of complex,from
R3787 T5314 T5313 arg1Of complex,this
R3788 T5316 T5315 arg2Of recruiting,by
R3789 T5316 T5318 arg1Of recruiting,to
R379 T515 T513 arg2Of and,of
R3790 T5317 T5316 arg2Of it,recruiting
R3791 T5320 T5318 arg2Of receptor,to
R3792 T5320 T5319 arg1Of receptor,the
R3793 T5322 T5308 arg1Of but,only
R3794 T5322 T5321 arg1Of but,","
R3795 T5322 T5323 arg1Of but,also
R3796 T5325 T5322 arg2Of attract,but
R3797 T5325 T5324 arg1Of attract,to
R3798 T5326 T5327 arg1Of TRAF2,and
R3799 T5327 T5325 arg2Of and,attract
R38 T43 T39 arg1Of diseases,many
R380 T519 T515 arg2Of diseases,and
R3800 T5327 T5329 arg1Of and,","
R3801 T5327 T5330 arg1Of and,which
R3802 T5327 T5331 arg1Of and,are
R3803 T5327 T5332 arg1Of and,essential
R3804 T5328 T5327 arg2Of cIAP1/2,and
R3805 T5332 T5331 arg2Of essential,are
R3806 T5332 T5333 arg1Of essential,for
R3807 T5336 T5333 arg2Of degradation,for
R3808 T5336 T5334 arg1Of degradation,subsequent
R3809 T5336 T5335 arg1Of degradation,TRAF3
R381 T519 T516 arg1Of diseases,many
R3810 T5338 T5337 arg1Of this,All
R3811 T5338 T5339 arg1Of this,contributes
R3812 T5339 T5340 arg1Of contributes,to
R3813 T5341 T5340 arg2Of releasing,to
R3814 T5341 T5343 arg1Of releasing,from
R3815 T5341 T5347 arg1Of releasing,","
R3816 T5341 T5348 modOf releasing,resulting
R3817 T5341 T5355 arg1Of releasing,[
R3818 T5341 T5358 arg1Of releasing,(
R3819 T5342 T5341 arg2Of NIK,releasing
R382 T519 T517 arg1Of diseases,other
R3820 T5346 T5343 arg2Of degradation,from
R3821 T5346 T5344 arg1Of degradation,its
R3822 T5346 T5345 arg1Of degradation,constitutive
R3823 T5348 T5349 arg1Of resulting,in
R3824 T5351 T5350 arg1Of accumulation,NIK
R3825 T5351 T5352 arg1Of accumulation,and
R3826 T5352 T5349 arg2Of and,in
R3827 T5389 T5387 arg2Of ligand,of
R3828 T5389 T5388 arg1Of ligand,their
R3829 T5354 T5352 arg2Of phosphorylation,and
R383 T519 T518 arg1Of diseases,autoimmune
R3830 T5391 T5392 arg1Of CD40,and
R3831 T5354 T5353 arg1Of phosphorylation,IKK1
R3832 T5392 T5394 arg1Of and,interact
R3833 T5393 T5392 arg2Of RANK,and
R3834 T5356 T5355 arg2Of "28,29",[
R3835 T5394 T5395 arg1Of interact,with
R3836 T5357 T5355 arg3Of ],[
R3837 T5394 T5412 arg1Of interact,and
R3838 T5359 T5358 arg2Of Figure,(
R3839 T5398 T5395 arg2Of members,with
R384 T520 T521 arg1Of NF-κB,represents
R3840 T5398 T5396 arg1Of members,several
R3841 T5398 T5397 arg1Of members,TRAF
R3842 T5398 T5399 arg1Of members,","
R3843 T5398 T5400 arg1Of members,including
R3844 T5401 T5402 arg1Of TRAF1,","
R3845 T5402 T5404 arg1Of ",",","
R3846 T5403 T5402 arg2Of TRAF2,","
R3847 T5359 T5360 arg1Of Figure,2
R3848 T5404 T5406 arg1Of ",",","
R3849 T5361 T5358 arg3Of ),(
R385 T523 T521 arg2Of family,represents
R3850 T5405 T5404 arg2Of TRAF3,","
R3851 T5406 T5409 arg1Of ",",and
R3852 T5407 T5406 arg2Of TRAF5,","
R3853 T5362 T5363 arg1Of It,should
R3854 T5409 T5400 arg2Of and,including
R3855 T5409 T5408 arg1Of and,","
R3856 T5410 T5409 arg2Of TRAF6,and
R3857 T5362 T5364 arg1Of It,be
R3858 T5412 T5385 arg1Of and,Upon
R3859 T5412 T5390 arg1Of and,","
R386 T523 T522 arg1Of family,a
R3860 T5412 T5411 arg1Of and,","
R3861 T5364 T5363 arg2Of be,should
R3862 T5413 T5414 arg1Of this,leads
R3863 T5414 T5412 arg2Of leads,and
R3864 T5414 T5415 arg1Of leads,to
R3865 T5367 T5364 arg2Of CD40,be
R3866 T5417 T5415 arg2Of proteolysis,to
R3867 T5417 T5416 arg1Of proteolysis,the
R3868 T5417 T5418 arg1Of proteolysis,of
R3869 T5417 T5423 arg1Of proteolysis,","
R387 T523 T524 arg1Of family,of
R3870 T5417 T5424 arg1Of proteolysis,which
R3871 T5417 T5425 arg1Of proteolysis,represents
R3872 T5420 T5421 arg1Of TRAF2,and
R3873 T5421 T5418 arg2Of and,of
R3874 T5421 T5419 arg1Of and,both
R3875 T5422 T5421 arg2Of TRAF3,and
R3876 T5367 T5365 arg2Of CD40,mentioned
R3877 T5425 T5436 arg1Of represents,as
R3878 T5367 T5366 arg1Of CD40,that
R3879 T5371 T5372 arg1Of receptor,and
R388 T523 T569 arg1Of family,-
R3880 T5428 T5425 arg2Of step,represents
R3881 T5428 T5426 arg1Of step,an
R3882 T5428 T5427 arg1Of step,important
R3883 T5428 T5429 arg1Of step,in
R3884 T5372 T5369 arg1Of and,lymphotoxin
R3885 T5372 T5370 arg1Of and,β
R3886 T5372 T5374 arg1Of and,mediate
R3887 T5431 T5429 arg2Of activation,in
R3888 T5431 T5430 arg1Of activation,the
R3889 T5431 T5432 arg1Of activation,of
R389 T523 T571 arg1Of family,as
R3890 T5435 T5432 arg2Of pathway,of
R3891 T5435 T5433 arg1Of pathway,the
R3892 T5435 T5434 arg1Of pathway,noncanonical
R3893 T5373 T5372 arg2Of RANK,and
R3894 T5437 T5436 arg2Of described,as
R3895 T5437 T5438 arg1Of described,above
R3896 T5374 T5363 modOf mediate,should
R3897 T5441 T5439 arg1Of molecules,Specific
R3898 T5441 T5440 arg1Of molecules,TRAF
R3899 T5441 T5442 arg1Of molecules,are
R39 T43 T40 arg1Of diseases,autoimmune
R390 T526 T525 arg1Of related,structurally
R3900 T5441 T5443 arg2Of molecules,associated
R3901 T5443 T5442 arg2Of associated,are
R3902 T5443 T5444 arg1Of associated,with
R3903 T5374 T5368 arg1Of mediate,","
R3904 T5376 T5374 arg2Of activation,mediate
R3905 T5376 T5375 arg1Of activation,the
R3906 T5449 T5444 arg2Of functions,with
R3907 T5449 T5445 arg1Of functions,overlapping
R3908 T5449 T5446 arg1Of functions,and
R3909 T5449 T5447 arg1Of functions,distinct
R391 T526 T527 arg1Of related,and
R3910 T5449 T5448 arg1Of functions,CD40-mediated
R3911 T5376 T5377 arg1Of activation,of
R3912 T5451 T5450 arg2Of example,For
R3913 T5379 T5380 arg1Of canonical,and
R3914 T5455 T5453 arg2Of cells,in
R3915 T5455 T5454 arg1Of cells,B
R3916 T5456 T5457 arg1Of TRAF6,is
R3917 T5456 T5458 arg2Of TRAF6,required
R3918 T5380 T5378 arg1Of and,both
R3919 T5458 T5457 arg2Of required,is
R392 T529 T527 arg2Of conserved,and
R3920 T5458 T5459 arg1Of required,for
R3921 T5458 T5466 arg1Of required,","
R3922 T5458 T5467 arg1Of required,while
R3923 T5458 T5476 arg1Of required,and
R3924 T5381 T5380 arg2Of noncanonical,and
R3925 T5462 T5460 arg1Of activation,CD40-mediated
R3926 T5462 T5461 arg1Of activation,JNK
R3927 T5462 T5463 arg1Of activation,and
R3928 T5463 T5459 arg2Of and,for
R3929 T5384 T5377 arg2Of pathways,of
R393 T529 T528 arg1Of conserved,evolutionarily
R3930 T5465 T5463 arg2Of production,and
R3931 T5465 T5464 arg1Of production,IL-6
R3932 T5468 T5469 arg1Of TRAF2,is
R3933 T5468 T5470 arg2Of TRAF2,required
R3934 T5470 T5467 arg2Of required,while
R3935 T5470 T5469 arg2Of required,is
R3936 T5470 T5471 arg1Of required,for
R3937 T5384 T5379 arg1Of pathways,canonical
R3938 T5472 T5471 arg2Of activation,for
R3939 T5472 T5473 arg1Of activation,of
R394 T530 T524 arg2Of proteins,of
R3940 T5474 T5473 arg2Of NF-κB,of
R3941 T5476 T5450 arg1Of and,For
R3942 T5476 T5452 arg1Of and,","
R3943 T5476 T5453 arg1Of and,in
R3944 T5476 T5475 arg1Of and,","
R3945 T5477 T5478 arg1Of TRAF3,serves
R3946 T5384 T5381 arg1Of pathways,noncanonical
R3947 T5478 T5476 arg2Of serves,and
R3948 T5478 T5479 arg1Of serves,as
R3949 T5384 T5382 arg1Of pathways,NF-κB
R395 T530 T526 arg1Of proteins,related
R3950 T5384 T5383 arg1Of pathways,signalling
R3951 T5386 T5385 arg2Of binding,Upon
R3952 T5478 T5486 arg1Of serves,[
R3953 T5386 T5387 arg1Of binding,of
R3954 T5485 T5483 arg2Of signalling,of
R3955 T5482 T5479 arg2Of regulator,as
R3956 T5482 T5480 arg1Of regulator,a
R3957 T5482 T5481 arg1Of regulator,negative
R3958 T5482 T5483 arg1Of regulator,of
R3959 T5485 T5484 arg1Of signalling,CD40
R396 T530 T529 arg1Of proteins,conserved
R3960 T5487 T5486 arg2Of "30,31",[
R3961 T5488 T5486 arg3Of ],[
R397 T530 T531 arg1Of proteins,(
R398 T530 T548 arg1Of proteins,that
R399 T530 T549 arg1Of proteins,function
R4 T8 T7 arg2Of NF-κB,of
R40 T43 T42 arg1Of diseases,inflammatory
R400 T530 T559 arg1Of proteins,that
R401 T530 T560 arg1Of proteins,regulate
R402 T532 T533 arg1Of p100,or
R403 T533 T535 arg1Of or,","
R404 T534 T533 arg2Of NF-κB2,or
R405 T535 T539 arg1Of ",",","
R406 T536 T537 arg1Of p105,or
R407 T537 T535 arg2Of or,","
R408 T538 T537 arg2Of NF-κB1,or
R409 T539 T541 arg1Of ",",or
R41 T43 T44 arg1Of diseases,","
R410 T540 T539 arg2Of p65,","
R411 T541 T531 arg2Of or,(
R412 T542 T541 arg2Of RelA,or
R413 T542 T543 arg1Of RelA,","
R414 T542 T545 arg1Of RelA,","
R415 T544 T543 arg2Of RelB,","
R416 T546 T545 arg2Of c-Rel,","
R417 T547 T531 arg3Of ),(
R418 T549 T550 arg1Of function,as
R419 T549 T558 arg1Of function,and
R42 T43 T45 arg1Of diseases,including
R420 T551 T552 arg1Of homodimers,or
R421 T552 T550 arg2Of or,as
R422 T552 T554 arg1Of or,[
R423 T553 T552 arg2Of heterodimers,or
R424 T555 T554 arg2Of 1,[
R425 T556 T554 arg3Of ],[
R426 T558 T557 arg1Of and,","
R427 T560 T558 arg2Of regulate,and
R428 T562 T560 arg2Of expression,regulate
R429 T562 T561 arg1Of expression,the
R43 T47 T45 arg2Of arthritis,including
R430 T562 T563 arg1Of expression,of
R431 T566 T563 arg2Of number,of
R432 T566 T564 arg1Of number,a
R433 T566 T565 arg1Of number,large
R434 T566 T567 arg1Of number,of
R435 T568 T567 arg2Of genes,of
R436 T571 T570 arg1Of as,such
R437 T572 T573 arg1Of TNF,","
R438 T573 T575 arg1Of ",",","
R439 T574 T573 arg2Of IL-1,","
R44 T47 T46 arg1Of arthritis,rheumatoid
R440 T575 T577 arg1Of ",",","
R441 T576 T575 arg2Of IL-6,","
R442 T577 T579 arg1Of ",",","
R443 T578 T577 arg2Of cyclo-oxygenase-2,","
R444 T579 T581 arg1Of ",",","
R445 T580 T579 arg2Of chemokines,","
R446 T581 T587 arg1Of ",",and
R447 T585 T581 arg2Of synthase,","
R448 T585 T582 arg1Of synthase,inducible
R449 T585 T583 arg1Of synthase,nitric
R45 T48 T49 arg1Of Cells,employ
R450 T585 T584 arg1Of synthase,oxide
R451 T587 T571 arg2Of and,as
R452 T587 T586 arg1Of and,","
R453 T589 T587 arg2Of metalloproteinases,and
R454 T589 T588 arg1Of metalloproteinases,matrix
R455 T589 T590 arg1Of metalloproteinases,-
R456 T589 T591 arg1Of metalloproteinases,that
R457 T589 T592 arg1Of metalloproteinases,are
R458 T589 T593 arg2Of metalloproteinases,involved
R459 T593 T592 arg2Of involved,are
R46 T49 T54 modOf employ,to
R460 T593 T594 arg1Of involved,in
R461 T595 T594 arg2Of RA,in
R462 T597 T596 arg2Of addition,In
R463 T599 T600 arg1Of TNF,and
R464 T600 T602 arg1Of and,are
R465 T601 T600 arg2Of IL-1,and
R466 T602 T596 arg1Of are,In
R467 T602 T598 arg1Of are,","
R468 T603 T602 arg2Of themselves,are
R469 T603 T606 arg1Of themselves,activators
R47 T53 T49 arg2Of system,employ
R470 T605 T604 arg1Of potent,very
R471 T606 T605 arg1Of activators,potent
R472 T606 T607 arg1Of activators,of
R473 T606 T609 arg1Of activators,(
R474 T608 T607 arg2Of NF-κB,of
R475 T610 T609 arg2Of reviewed,(
R476 T610 T611 arg1Of reviewed,in
R477 T610 T612 arg1Of reviewed,[
R478 T613 T612 arg2Of "2,3",[
R479 T614 T612 arg3Of ],[
R48 T53 T50 arg1Of system,a
R480 T615 T609 arg3Of ),(
R481 T617 T616 arg1Of activation,NF-κB
R482 T617 T618 arg1Of activation,can
R483 T617 T619 arg1Of activation,be
R484 T617 T620 arg2Of activation,detected
R485 T620 T618 arg2Of detected,can
R486 T620 T619 arg2Of detected,be
R487 T620 T621 arg1Of detected,in
R488 T620 T632 arg1Of detected,and
R489 T624 T622 arg2Of fibroblasts,cultured
R49 T53 T51 arg1Of system,multilayered
R490 T624 T623 arg1Of fibroblasts,synovial
R491 T624 T625 arg1Of fibroblasts,and
R492 T625 T621 arg2Of and,in
R493 T627 T625 arg2Of tissue,and
R494 T627 T626 arg1Of tissue,synovial
R495 T627 T628 arg1Of tissue,from
R496 T630 T628 arg2Of patients,from
R497 T630 T629 arg1Of patients,RA
R498 T632 T631 arg1Of and,","
R499 T634 T633 arg1Of models,animal
R5 T11 T9 arg2Of involvement,and
R50 T53 T52 arg1Of system,control
R500 T634 T635 arg1Of models,of
R501 T634 T639 arg1Of models,demonstrate
R502 T637 T635 arg2Of arthritis,of
R503 T637 T636 arg1Of arthritis,inflammatory
R504 T639 T632 arg2Of demonstrate,and
R505 T639 T638 arg1Of demonstrate,also
R506 T642 T639 arg2Of role,demonstrate
R507 T642 T640 arg1Of role,the
R508 T642 T641 arg1Of role,active
R509 T642 T643 arg1Of role,of
R51 T55 T54 arg1Of keep,to
R510 T642 T645 arg1Of role,in
R511 T642 T652 arg1Of role,(
R512 T644 T643 arg2Of NF-κB,of
R513 T647 T648 arg1Of development,and
R514 T648 T645 arg2Of and,in
R515 T648 T646 arg1Of and,the
R516 T648 T650 arg1Of and,of
R517 T649 T648 arg2Of progression,and
R518 T651 T650 arg2Of RA,of
R519 T653 T652 arg2Of reviewed,(
R52 T55 T58 arg1Of keep,in
R520 T653 T654 arg1Of reviewed,in
R521 T653 T655 arg1Of reviewed,[
R522 T656 T655 arg2Of 4,[
R523 T657 T655 arg3Of ],[
R524 T658 T652 arg3Of ),(
R525 T661 T659 arg1Of course,The
R526 T661 T660 arg1Of course,time
R527 T661 T662 arg1Of course,of
R528 T661 T665 arg1Of course,appears
R529 T661 T667 arg1Of course,precede
R53 T57 T55 arg2Of signalling,keep
R530 T664 T662 arg2Of activation,of
R531 T664 T663 arg1Of activation,NF-κB
R532 T665 T673 arg1Of appears,and
R533 T667 T665 arg2Of precede,appears
R534 T667 T666 arg1Of precede,to
R535 T669 T667 arg2Of onset,precede
R536 T669 T668 arg1Of onset,the
R537 T669 T670 arg1Of onset,of
R538 T671 T670 arg2Of disease,of
R539 T673 T672 arg1Of and,","
R54 T57 T56 arg1Of signalling,NF-κB
R540 T674 T675 arg1Of blockade,of
R541 T674 T677 arg1Of blockade,by
R542 T674 T680 arg1Of blockade,decreases
R543 T676 T675 arg2Of NF-κB,of
R544 T679 T677 arg2Of means,by
R545 T679 T678 arg1Of means,different
R546 T680 T673 arg2Of decreases,and
R547 T680 T683 arg1Of decreases,[
R548 T682 T680 arg2Of severity,decreases
R549 T682 T681 arg1Of severity,disease
R55 T59 T58 arg2Of check,in
R550 T684 T683 arg2Of "5,6",[
R551 T685 T683 arg3Of ],[
R552 T686 T687 arg1Of Next,to
R553 T689 T687 arg2Of role,to
R554 T689 T688 arg1Of role,its
R555 T689 T690 arg1Of role,in
R556 T693 T690 arg2Of expression,in
R557 T693 T691 arg1Of expression,proinflammatory
R558 T693 T692 arg1Of expression,gene
R559 T695 T696 arg1Of NF-κB,is
R5593 T8428 T8427 arg1Of activation,NF-κB
R5594 T8428 T8429 arg1Of activation,is
R5595 T8428 T8431 arg1Of activation,crucial
R5596 T8429 T8426 arg2Of is,Since
R5597 T8431 T8429 arg2Of crucial,is
R5598 T8431 T8430 arg1Of crucial,so
R5599 T8431 T8432 arg1Of crucial,to
R56 T59 T60 arg1Of check,","
R560 T695 T698 arg1Of NF-κB,essential
R5600 T8435 T8432 arg2Of processes,to
R5601 T8435 T8433 arg1Of processes,many
R5602 T8435 T8434 arg1Of processes,cellular
R5603 T8439 T8437 arg1Of regulation,a
R5604 T8439 T8438 arg1Of regulation,tight
R5605 T8439 T8440 arg1Of regulation,of
R5606 T8439 T8445 arg1Of regulation,and
R5607 T8444 T8440 arg2Of pathway,of
R5608 T8444 T8441 arg1Of pathway,the
R5609 T8444 T8442 arg1Of pathway,NF-κB
R561 T695 T704 arg1Of NF-κB,mediating
R5610 T8444 T8443 arg1Of pathway,signalling
R5611 T8445 T8450 arg1Of and,is
R5612 T8447 T8445 arg2Of genes,and
R5613 T8447 T8446 arg1Of genes,the
R5614 T8447 T8449 arg2Of genes,induces
R5615 T8448 T8449 arg1Of it,induces
R5616 T8450 T8426 arg1Of is,Since
R5617 T8450 T8436 arg1Of is,","
R5618 T8453 T8450 arg2Of requirement,is
R5619 T8453 T8451 arg1Of requirement,an
R562 T696 T686 arg1Of is,Next
R5620 T8453 T8452 arg1Of requirement,absolute
R5621 T8453 T8454 modOf requirement,to
R5622 T8453 T8455 arg1Of requirement,fine-tune
R5623 T8455 T8454 arg1Of fine-tune,to
R5624 T8458 T8455 arg2Of response,fine-tune
R5625 T8458 T8456 arg1Of response,the
R5626 T8458 T8457 arg1Of response,inflammatory
R5627 T8461 T8465 arg1Of terminating,is
R5628 T8461 T8466 arg1Of terminating,essential
R5629 T8464 T8461 arg2Of response,terminating
R563 T696 T694 arg1Of is,","
R5630 T8464 T8462 arg1Of response,an
R5631 T8464 T8463 arg1Of response,NF-κB
R5632 T8465 T8459 arg1Of is,Moreover
R5633 T8465 T8460 arg1Of is,","
R5634 T8466 T8465 arg2Of essential,is
R5635 T8468 T8466 arg2Of prevent,essential
R5636 T8468 T8467 arg1Of prevent,to
R5637 T8471 T8468 arg2Of activation,prevent
R5638 T8471 T8469 arg1Of activation,persistent
R5639 T8471 T8470 arg1Of activation,NF-κB
R564 T696 T697 arg1Of is,also
R5640 T8471 T8472 arg1Of activation,that
R5641 T8471 T8473 arg1Of activation,may
R5642 T8471 T8474 arg1Of activation,lead
R5643 T8474 T8473 arg2Of lead,may
R5644 T8474 T8475 arg1Of lead,to
R5645 T8477 T8478 arg1Of inflammation,and/or
R5646 T8478 T8475 arg2Of and/or,to
R5647 T8478 T8476 arg1Of and/or,chronic
R5648 T8479 T8478 arg2Of tumorigenesis,and/or
R5649 T8481 T8480 arg1Of achieve,To
R565 T696 T701 arg1Of is,","
R5650 T8482 T8481 arg2Of this,achieve
R5651 T8484 T8481 arg1Of cells,achieve
R5652 T8484 T8485 arg1Of cells,employ
R5653 T8485 T8480 modOf employ,To
R5654 T8485 T8483 arg1Of employ,","
R5655 T8487 T8485 arg2Of mechanisms,employ
R5656 T8487 T8486 arg1Of mechanisms,different
R5657 T8487 T8488 arg1Of mechanisms,","
R5658 T8487 T8489 arg1Of mechanisms,including
R5659 T8491 T8489 arg2Of expression,including
R566 T696 T703 arg1Of is,by
R5660 T8491 T8490 arg1Of expression,the
R5661 T8491 T8492 arg1Of expression,of
R5662 T8494 T8492 arg2Of proteins,of
R5663 T8494 T8493 arg1Of proteins,inhibitory
R5664 T8494 T8495 arg1Of proteins,that
R5665 T8494 T8496 arg1Of proteins,downregulate
R5666 T8496 T8499 arg1Of downregulate,[
R5667 T8498 T8496 arg2Of signalling,downregulate
R5668 T8498 T8497 arg1Of signalling,NF-κB
R5669 T8500 T8499 arg2Of 32,[
R567 T698 T696 arg2Of essential,is
R5670 T8501 T8499 arg3Of ],[
R5671 T8503 T8504 arg1Of we,give
R5672 T8504 T8524 arg1Of give,","
R5673 T8506 T8504 arg2Of overview,give
R5674 T8506 T8505 arg1Of overview,an
R5675 T8506 T8507 arg1Of overview,of
R5676 T8509 T8507 arg2Of number,of
R5677 T8509 T8508 arg1Of number,a
R5678 T8509 T8510 arg1Of number,of
R5679 T8511 T8510 arg2Of proteins,of
R568 T698 T699 arg1Of essential,for
R5680 T8511 T8512 arg1Of proteins,that
R5681 T8511 T8513 arg1Of proteins,are
R5682 T8511 T8514 arg2Of proteins,involved
R5683 T8514 T8513 arg2Of involved,are
R5684 T8514 T8515 arg1Of involved,in
R5685 T8517 T8518 arg1Of dampening,or
R5686 T8518 T8515 arg2Of or,in
R5687 T8518 T8516 arg1Of or,the
R5688 T8518 T8520 arg1Of or,of
R5689 T8519 T8518 arg2Of termination,or
R569 T700 T699 arg2Of osteoclastogenesis,for
R5690 T8523 T8520 arg2Of response,of
R5691 T8523 T8521 arg1Of response,the
R5692 T8523 T8522 arg1Of response,NF-κB
R5693 T8525 T8504 arg3Of some,give
R5694 T8525 T8526 arg1Of some,of
R5695 T8527 T8526 arg2Of them,of
R5696 T8530 T8528 arg2Of control,under
R5697 T8530 T8529 arg1Of control,the
R5698 T8530 T8531 arg1Of control,of
R5699 T8533 T8531 arg2Of itself,of
R57 T59 T61 arg1Of check,including
R570 T703 T702 arg1Of by,mainly
R5700 T8533 T8532 arg1Of itself,NF-κB
R5701 T8536 T8534 arg2Of acting,and
R5702 T8536 T8535 arg1Of acting,thus
R5703 T8536 T8537 arg1Of acting,in
R5704 T8541 T8537 arg2Of loop,in
R5705 T8541 T8538 arg1Of loop,a
R5706 T8541 T8539 arg1Of loop,negative
R5707 T8541 T8540 arg1Of loop,feedback
R5708 T8543 T8542 arg2Of addition,In
R5709 T8545 T8546 arg1Of we,discuss
R571 T704 T703 arg2Of mediating,by
R5710 T8546 T8542 arg1Of discuss,In
R5711 T8546 T8544 arg1Of discuss,","
R5712 T8549 T8546 arg2Of role,discuss
R5713 T8549 T8547 arg1Of role,the
R5714 T8549 T8548 arg1Of role,potential
R5715 T8549 T8550 arg1Of role,of
R5716 T8549 T8555 arg1Of role,in
R5717 T8554 T8550 arg2Of factors,of
R5718 T8554 T8551 arg1Of factors,these
R5719 T8554 T8552 arg1Of factors,NF-κB
R572 T706 T704 arg2Of effects,mediating
R5720 T8554 T8553 arg1Of factors,inhibitory
R5721 T8557 T8555 arg2Of immunopathology,in
R5722 T8557 T8556 arg1Of immunopathology,the
R5723 T8557 T8558 arg1Of immunopathology,of
R5724 T8559 T8558 arg2Of RA,of
R5725 T8562 T8560 arg1Of proteins,Several
R5726 T8562 T8561 arg1Of proteins,other
R5727 T8562 T8563 arg2Of proteins,involved
R5728 T8562 T8572 arg1Of proteins,","
R5729 T8562 T8574 arg1Of proteins,as
R573 T706 T705 arg1Of effects,the
R5730 T8562 T8582 arg1Of proteins,have
R5731 T8562 T8583 arg1Of proteins,been
R5732 T8562 T8584 arg2Of proteins,described
R5733 T8563 T8564 arg1Of involved,in
R5734 T8567 T8564 arg2Of regulation,in
R5735 T8567 T8565 arg1Of regulation,the
R5736 T8567 T8566 arg1Of regulation,negative
R5737 T8567 T8568 arg1Of regulation,of
R5738 T8571 T8568 arg2Of responses,of
R5739 T8571 T8569 arg1Of responses,NF-κB-dependent
R574 T706 T707 arg1Of effects,of
R5740 T8571 T8570 arg1Of responses,inflammatory
R5741 T8574 T8573 arg1Of as,such
R5742 T8575 T8576 arg1Of MyD88s,","
R5743 T8576 T8579 arg1Of ",",and
R5744 T8577 T8576 arg2Of IRAK-M,","
R5745 T8579 T8574 arg2Of and,as
R5746 T8579 T8578 arg1Of and,","
R5747 T8580 T8579 arg2Of TOLLIP,and
R5748 T8584 T8581 arg1Of described,","
R5749 T8584 T8582 arg2Of described,have
R575 T709 T707 arg2Of activator,of
R5750 T8584 T8583 arg2Of described,been
R5751 T8584 T8585 arg1Of described,(
R5752 T8586 T8585 arg2Of reviewed,(
R5753 T8586 T8587 arg1Of reviewed,in
R5754 T8586 T8588 arg1Of reviewed,[
R5755 T8589 T8588 arg2Of 33,[
R5756 T8590 T8588 arg3Of ],[
R5757 T8591 T8585 arg3Of ),(
R5758 T8593 T8592 arg1Of proteins,These
R5759 T8593 T8594 arg1Of proteins,are
R576 T709 T708 arg1Of activator,receptor
R5760 T8593 T8596 arg2Of proteins,discussed
R5761 T8596 T8594 arg2Of discussed,are
R5762 T8596 T8595 arg1Of discussed,not
R5763 T8596 T8597 arg1Of discussed,here
R5764 T8596 T8598 arg1Of discussed,","
R5765 T8596 T8599 arg1Of discussed,since
R5766 T8601 T8600 arg1Of link,a
R5767 T8601 T8602 arg1Of link,with
R5768 T8601 T8605 arg1Of link,has
R5769 T8601 T8608 arg1Of link,been
R577 T709 T710 arg1Of activator,of
R5770 T8604 T8602 arg2Of pathology,with
R5771 T8604 T8603 arg1Of pathology,RA
R5772 T8608 T8605 arg2Of been,has
R5773 T8608 T8606 arg1Of been,not
R5774 T8608 T8607 arg1Of been,yet
R5775 T8608 T8609 arg1Of been,"reported. Although"
R5776 T8608 T8620 arg1Of been,","
R5777 T8610 T8611 arg1Of IKK1,is
R5778 T8611 T8609 arg2Of is,"reported. Although"
R5779 T8614 T8611 arg2Of component,is
R578 T712 T710 arg2Of ligand,of
R5780 T8614 T8612 arg1Of component,a
R5781 T8614 T8613 arg1Of component,critical
R5782 T8614 T8615 arg1Of component,of
R5783 T8619 T8615 arg2Of pathway,of
R5784 T8619 T8616 arg1Of pathway,the
R5785 T8619 T8617 arg1Of pathway,non-canonical
R5786 T8619 T8618 arg1Of pathway,NF-κB
R5787 T8620 T8599 arg2Of ",",since
R5788 T8621 T8622 arg1Of it,should
R5789 T8621 T8623 arg1Of it,be
R579 T712 T711 arg1Of ligand,NF-κB
R5790 T8621 T8624 arg2Of it,mentioned
R5791 T8624 T8622 arg2Of mentioned,should
R5792 T8624 T8623 arg2Of mentioned,be
R5793 T8624 T8625 arg1Of mentioned,that
R5794 T8627 T8626 arg1Of kinase,this
R5795 T8627 T8629 arg1Of kinase,plays
R5796 T8629 T8620 arg2Of plays,","
R5797 T8629 T8622 modOf plays,should
R5798 T8629 T8628 arg1Of plays,also
R5799 T8629 T8633 arg1Of plays,in
R58 T63 T61 arg2Of repertoire,including
R580 T712 T713 arg1Of ligand,(
R5800 T8632 T8629 arg2Of role,plays
R5801 T8632 T8630 arg1Of role,a
R5802 T8632 T8631 arg1Of role,prominent
R5803 T8636 T8633 arg2Of regulation,in
R5804 T8636 T8634 arg1Of regulation,the
R5805 T8636 T8635 arg1Of regulation,negative
R5806 T8636 T8637 arg1Of regulation,of
R5807 T8639 T8640 arg1Of canonical,and
R5808 T8640 T8638 arg1Of and,both
R5809 T8641 T8640 arg2Of noncanonical,and
R581 T714 T713 arg2Of RANKL,(
R5810 T8643 T8637 arg2Of pathways,of
R5811 T8643 T8639 arg1Of pathways,canonical
R5812 T8643 T8641 arg1Of pathways,noncanonical
R5813 T8643 T8642 arg1Of pathways,NF-κB
R5814 T8644 T8645 arg1Of Macrophages,from
R5815 T8644 T8654 arg1Of Macrophages,show
R5816 T8647 T8646 arg1Of mice,IKK1-deficient
R5817 T8647 T8648 arg1Of mice,or
R5818 T8648 T8645 arg2Of or,from
R5819 T8650 T8648 arg2Of mice,or
R582 T715 T713 arg3Of ),(
R5820 T8650 T8649 arg1Of mice,knockin
R5821 T8650 T8651 arg1Of mice,expressing
R5822 T8653 T8651 arg2Of IKK1,expressing
R5823 T8653 T8652 arg1Of IKK1,inactive
R5824 T8654 T8660 arg1Of show,as
R5825 T8654 T8670 arg1Of show,[
R5826 T8656 T8654 arg2Of production,show
R5827 T8656 T8655 arg2Of production,increased
R5828 T8656 T8657 arg1Of production,of
R5829 T8659 T8657 arg2Of cytokines,of
R583 T716 T717 arg1Of Defects,in
R5830 T8659 T8658 arg1Of cytokines,proinflammatory
R5831 T8662 T8660 arg2Of result,as
R5832 T8662 T8661 arg1Of result,a
R5833 T8662 T8663 arg1Of result,of
R5834 T8666 T8664 arg2Of activation,enhanced
R5835 T8666 T8665 arg1Of activation,IKK2
R5836 T8666 T8667 arg1Of activation,and
R5837 T8667 T8663 arg2Of and,of
R5838 T8669 T8667 arg2Of degradation,and
R5839 T8669 T8668 arg1Of degradation,IκBα
R584 T716 T722 arg1Of Defects,are
R5840 T8671 T8670 arg2Of 34,[
R5841 T8672 T8670 arg3Of ],[
R5842 T8673 T8674 arg1Of IKK1,has
R5843 T8673 T8676 arg1Of IKK1,been
R5844 T8673 T8677 arg2Of IKK1,shown
R5845 T8673 T8679 arg1Of IKK1,inhibit
R5846 T8673 T8684 arg1Of IKK1,downregulate
R5847 T8673 T8688 arg1Of IKK1,phosphorylating
R5848 T8677 T8674 arg2Of shown,has
R5849 T8677 T8675 arg1Of shown,also
R585 T719 T717 arg2Of regulation,in
R5850 T8677 T8676 arg2Of shown,been
R5851 T8679 T8678 arg1Of inhibit,to
R5852 T8679 T8682 arg1Of inhibit,and
R5853 T8681 T8679 arg2Of NF-κB,inhibit
R5854 T8681 T8680 arg1Of NF-κB,nuclear
R5855 T8682 T8677 arg3Of and,shown
R5856 T8684 T8682 arg2Of downregulate,and
R5857 T8684 T8683 arg1Of downregulate,to
R5858 T8684 T8687 arg1Of downregulate,by
R5859 T8686 T8684 arg2Of signalling,downregulate
R586 T719 T718 arg1Of regulation,the
R5860 T8686 T8685 arg1Of signalling,proinflammatory
R5861 T8688 T8687 arg2Of phosphorylating,by
R5862 T8689 T8688 arg2Of STAT1,phosphorylating
R5863 T8689 T8690 arg1Of STAT1,[
R5864 T8691 T8690 arg2Of 35,[
R5865 T8692 T8690 arg3Of ],[
R5866 T8697 T8695 arg1Of study,a
R5867 T8697 T8696 arg1Of study,recent
R5868 T8697 T8698 arg1Of study,has
R5869 T8697 T8699 arg1Of study,demonstrated
R587 T719 T720 arg1Of regulation,of
R5870 T8699 T8693 arg1Of demonstrated,Interestingly
R5871 T8699 T8694 arg1Of demonstrated,","
R5872 T8699 T8698 arg2Of demonstrated,has
R5873 T8701 T8702 arg1Of IKK1,phosphorylates
R5874 T8702 T8699 arg2Of phosphorylates,demonstrated
R5875 T8702 T8700 arg1Of phosphorylates,that
R5876 T8702 T8704 arg1Of phosphorylates,in
R5877 T8702 T8716 arg1Of phosphorylates,","
R5878 T8702 T8717 modOf phosphorylates,supporting
R5879 T8703 T8702 arg2Of NIK,phosphorylates
R588 T721 T720 arg2Of osteoclastogenesis,of
R5880 T8707 T8704 arg2Of regulation,in
R5881 T8707 T8705 arg1Of regulation,negative
R5882 T8707 T8706 arg1Of regulation,feedback
R5883 T8707 T8708 arg1Of regulation,of
R5884 T8712 T8708 arg2Of pathway,of
R5885 T8712 T8709 arg1Of pathway,the
R5886 T8712 T8710 arg1Of pathway,noncanonical
R5887 T8712 T8711 arg1Of pathway,NF-κB
R5888 T8712 T8713 arg1Of pathway,[
R5889 T8714 T8713 arg2Of 36,[
R589 T722 T729 arg1Of are,in
R5890 T8715 T8713 arg3Of ],[
R5891 T8719 T8717 arg2Of idea,supporting
R5892 T8719 T8718 arg1Of idea,the
R5893 T8721 T8722 arg1Of IKK1,plays
R5894 T8721 T8726 arg1Of IKK1,terminating
R5895 T8722 T8719 arg2Of plays,idea
R5896 T8722 T8720 arg1Of plays,that
R5897 T8722 T8725 arg1Of plays,in
R5898 T8724 T8722 arg2Of roles,plays
R5899 T8724 T8723 arg1Of roles,important
R59 T63 T62 arg1Of repertoire,a
R590 T725 T722 arg2Of cause,are
R5900 T8726 T8725 arg2Of terminating,in
R5901 T8728 T8729 arg1Of canonical,and
R5902 T8729 T8727 arg1Of and,both
R5903 T8730 T8729 arg2Of noncanonical,and
R5904 T8732 T8726 arg2Of pathways,terminating
R5905 T8732 T8728 arg1Of pathways,canonical
R5906 T8732 T8730 arg1Of pathways,noncanonical
R5907 T8732 T8731 arg1Of pathways,NF-κB
R5908 T8732 T8733 arg1Of pathways,with
R5909 T8735 T8733 arg2Of implications,with
R591 T725 T723 arg1Of cause,the
R5910 T8735 T8734 arg1Of implications,possible
R5911 T8735 T8736 arg1Of implications,for
R5912 T8739 T8736 arg2Of diseases,for
R5913 T8739 T8737 arg1Of diseases,chronic
R5914 T8739 T8738 arg1Of diseases,inflammatory
R5915 T8739 T8740 arg1Of diseases,like
R5916 T8741 T8740 arg2Of RA,like
R592 T725 T724 arg1Of cause,major
R593 T725 T726 arg1Of cause,of
R594 T728 T726 arg2Of erosion,of
R595 T728 T727 arg1Of erosion,bone
R596 T731 T729 arg2Of diseases,in
R597 T731 T730 arg1Of diseases,osteolytic
R598 T731 T733 arg1Of diseases,as
R599 T733 T732 arg1Of as,such
R6 T11 T10 arg1Of involvement,its
R60 T63 T64 arg1Of repertoire,of
R600 T734 T733 arg2Of RA,as
R601 T734 T735 arg1Of RA,[
R602 T736 T735 arg2Of 7,[
R603 T737 T735 arg3Of ],[
R604 T741 T740 arg1Of discoveries,recent
R605 T741 T742 arg1Of discoveries,revealing
R606 T741 T765 arg1Of discoveries,highlight
R607 T745 T742 arg2Of association,revealing
R608 T745 T743 arg1Of association,a
R609 T745 T744 arg1Of association,genetic
R61 T67 T64 arg2Of regulators,of
R610 T745 T746 arg1Of association,with
R611 T748 T746 arg2Of genes,with
R612 T748 T747 arg1Of genes,several
R613 T748 T749 arg1Of genes,relevant
R614 T748 T753 arg1Of genes,","
R615 T748 T754 arg1Of genes,including
R616 T749 T750 arg1Of relevant,to
R617 T752 T750 arg2Of signalling,to
R618 T752 T751 arg1Of signalling,NF-κB
R619 T755 T756 arg1Of CD40,","
R62 T67 T65 arg1Of regulators,negative
R620 T756 T758 arg1Of ",",","
R621 T757 T756 arg2Of TRAF1,","
R622 T758 T761 arg1Of ",",and
R623 T759 T758 arg2Of TNFAIP3,","
R624 T761 T754 arg2Of and,including
R625 T761 T760 arg1Of and,","
R626 T762 T761 arg2Of c-REL,and
R627 T765 T738 arg1Of highlight,Finally
R628 T765 T739 arg1Of highlight,","
R629 T765 T763 arg1Of highlight,","
R63 T67 T66 arg1Of regulators,feedback
R630 T765 T764 arg1Of highlight,further
R631 T765 T774 arg1Of highlight,[
R632 T767 T765 arg2Of importance,highlight
R633 T767 T766 arg1Of importance,the
R634 T767 T768 arg1Of importance,of
R635 T767 T771 arg1Of importance,in
R636 T770 T768 arg2Of activation,of
R637 T770 T769 arg1Of activation,NF-κB
R638 T773 T771 arg2Of pathogenesis,in
R639 T773 T772 arg1Of pathogenesis,RA
R64 T67 T68 arg1Of regulators,ensuring
R640 T775 T774 arg2Of 8,[
R641 T776 T774 arg3Of ],[
R6414 T9822 T9821 arg1Of protein,A20
R6415 T9823 T9824 arg1Of A20,(
R6416 T9823 T9830 arg1Of A20,is
R6417 T9826 T9824 arg2Of known,(
R6418 T9826 T9825 arg1Of known,also
R6419 T9826 T9827 arg1Of known,as
R6420 T9828 T9827 arg2Of TNFAIP3,as
R6421 T9829 T9824 arg3Of ),(
R6422 T9833 T9830 arg2Of protein,is
R6423 T9833 T9831 arg1Of protein,a
R6424 T9833 T9832 arg1Of protein,ubiquitin-editing
R6425 T9833 T9834 arg1Of protein,that
R6426 T9833 T9836 arg1Of protein,regulates
R6427 T9836 T9835 arg1Of regulates,negatively
R6428 T9836 T9840 arg1Of regulates,in
R6429 T9839 T9836 arg2Of expression,regulates
R6430 T9839 T9837 arg1Of expression,NF-κB-dependent
R6431 T9839 T9838 arg1Of expression,gene
R6432 T9841 T9840 arg2Of response,in
R6433 T9841 T9842 arg1Of response,to
R6434 T9845 T9842 arg2Of stimuli,to
R6435 T9845 T9843 arg1Of stimuli,different
R6436 T9845 T9844 arg1Of stimuli,immune-activating
R6437 T9845 T9846 arg1Of stimuli,","
R6438 T9845 T9847 arg1Of stimuli,including
R6439 T9848 T9849 arg1Of TNF,","
R6440 T9849 T9851 arg1Of ",",and
R6441 T9850 T9849 arg2Of IL-1,","
R6442 T9851 T9854 arg1Of and,and
R6443 T9852 T9851 arg2Of antigens,and
R6444 T9854 T9847 arg2Of and,including
R6445 T9854 T9853 arg1Of and,","
R6446 T9856 T9854 arg2Of triggering,and
R6447 T9856 T9855 arg1Of triggering,the
R6448 T9856 T9857 arg1Of triggering,of
R6449 T9858 T9859 arg1Of TLRs,and
R6450 T9859 T9857 arg2Of and,of
R6451 T9862 T9860 arg1Of oligomerisation,the
R6452 T9862 T9861 arg1Of oligomerisation,nucleotide-binding
R6453 T9865 T9859 arg2Of receptor,and
R6454 T9865 T9862 arg1Of receptor,oligomerisation
R6455 T9865 T9863 arg1Of receptor,domain-containing
R6456 T9865 T9864 arg1Of receptor,2
R6457 T9865 T9866 arg1Of receptor,(
R6458 T9867 T9866 arg2Of reviewed,(
R6459 T9867 T9868 arg1Of reviewed,in
R6460 T9867 T9869 arg1Of reviewed,[
R6461 T9870 T9869 arg2Of 37,[
R6462 T9871 T9869 arg3Of ],[
R6463 T9872 T9866 arg3Of ),(
R6464 T9873 T9874 arg1Of A20,is
R6465 T9873 T9875 arg2Of A20,believed
R6466 T9873 T9877 arg1Of A20,inhibit
R6467 T9873 T9881 arg1Of A20,deubiquitinating
R6468 T9875 T9874 arg2Of believed,is
R6469 T9877 T9875 arg3Of inhibit,believed
R6470 T9877 T9876 arg1Of inhibit,to
R6471 T9877 T9880 arg1Of inhibit,by
R6472 T9879 T9877 arg2Of function,inhibit
R6473 T9879 T9878 arg1Of function,NF-κB
R6474 T9881 T9880 arg2Of deubiquitinating,by
R6475 T9885 T9881 arg2Of molecules,deubiquitinating
R6476 T9885 T9882 arg1Of molecules,specific
R6477 T9885 T9883 arg1Of molecules,NF-κB
R6478 T9885 T9884 arg1Of molecules,signalling
R6479 T9885 T9886 arg1Of molecules,","
R6480 T9885 T9888 arg1Of molecules,as
R6481 T9888 T9887 arg1Of as,such
R6482 T9889 T9890 arg1Of RIP1,","
R6483 T9890 T9892 arg1Of ",",","
R6484 T9891 T9890 arg2Of RIP2,","
R6485 T9892 T9894 arg1Of ",",and
R6486 T9893 T9892 arg2Of TRAF6,","
R6487 T9894 T9888 arg2Of and,as
R6488 T9894 T9896 arg1Of and,","
R6489 T9894 T9897 arg1Of and,which
R6490 T9894 T9898 arg1Of and,disrupts
R6491 T9895 T9894 arg2Of MALT1,and
R6492 T9898 T9902 arg1Of disrupts,[
R6493 T9898 T9905 arg1Of disrupts,(
R6494 T9901 T9898 arg2Of interactions,disrupts
R6495 T9901 T9899 arg1Of interactions,specific
R6496 T9901 T9900 arg1Of interactions,protein-protein
R6497 T9903 T9902 arg2Of 38-41,[
R6498 T9904 T9902 arg3Of ],[
R6499 T9906 T9905 arg2Of Figure,(
R65 T69 T68 arg2Of termination,ensuring
R6500 T9906 T9907 arg1Of Figure,1
R6501 T9908 T9905 arg3Of ),(
R6502 T9912 T9911 arg1Of disruption,the
R6503 T9912 T9913 arg1Of disruption,of
R6504 T9912 T9915 arg1Of disruption,between
R6505 T9912 T9925 arg1Of disruption,and
R6506 T9914 T9913 arg2Of interactions,of
R6507 T9919 T9915 arg2Of enzymes,between
R6508 T9919 T9916 arg1Of enzymes,E2
R6509 T9919 T9917 arg1Of enzymes,ubiquitin
R6510 T9919 T9918 arg1Of enzymes,conjugating
R6511 T9919 T9920 arg1Of enzymes,(
R6512 T9921 T9922 arg1Of Ubc13,and
R6513 T9922 T9920 arg2Of and,(
R6514 T9923 T9922 arg2Of Ubc5hc,and
R6515 T9924 T9920 arg3Of ),(
R6516 T9925 T9936 arg1Of and,were
R6517 T9925 T9937 arg2Of and,described
R6518 T9928 T9925 arg2Of ligases,and
R6519 T9928 T9926 arg1Of ligases,E3
R6520 T9928 T9927 arg1Of ligases,ubiquitin
R6521 T9928 T9929 arg1Of ligases,(
R6522 T9930 T9931 arg1Of TRAF6,","
R6523 T9931 T9933 arg1Of ",",and
R6524 T9932 T9931 arg2Of TRAF2,","
R6525 T9933 T9929 arg2Of and,(
R6526 T9934 T9933 arg2Of cIAP1/2,and
R6527 T9935 T9929 arg3Of ),(
R6528 T9937 T9909 arg1Of described,Recently
R6529 T9937 T9910 arg1Of described,","
R6530 T9937 T9936 arg2Of described,were
R6531 T9937 T9938 arg1Of described,as
R6532 T9941 T9938 arg2Of mechanism,as
R6533 T9941 T9939 arg1Of mechanism,another
R6534 T9941 T9940 arg1Of mechanism,important
R6535 T9941 T9942 arg2Of mechanism,used
R6536 T9942 T9943 arg1Of used,by
R6537 T9942 T9945 modOf used,to
R6538 T9944 T9943 arg2Of A20,by
R6539 T9946 T9945 arg1Of downregulate,to
R6540 T9946 T9949 arg1Of downregulate,[
R6541 T9948 T9946 arg2Of signalling,downregulate
R6542 T9948 T9947 arg1Of signalling,NF-κB
R6543 T9950 T9949 arg2Of 42,[
R6544 T9951 T9949 arg3Of ],[
R6545 T9953 T9952 arg1Of association,The
R6546 T9953 T9954 arg1Of association,of
R6547 T9953 T9956 arg1Of association,with
R6548 T9953 T9959 arg1Of association,requires
R6549 T9955 T9954 arg2Of A20,of
R6550 T9958 T9956 arg2Of targets,with
R6551 T9958 T9957 arg1Of targets,its
R6552 T9963 T9959 arg2Of proteins,requires
R6553 T9963 T9960 arg1Of proteins,specific
R6554 T9963 T9961 arg1Of proteins,ubiquitin-binding
R6555 T9963 T9962 arg1Of proteins,adaptor
R6556 T9963 T9964 arg1Of proteins,","
R6557 T9963 T9965 arg1Of proteins,including
R6558 T9967 T9965 arg2Of inhibitor,including
R6559 T9967 T9966 arg1Of inhibitor,A20-binding
R6560 T9967 T9968 arg1Of inhibitor,of
R6561 T9969 T9970 arg1Of NF-κB,(
R6562 T9969 T9973 arg1Of NF-κB,1
R6563 T9969 T9974 arg1Of NF-κB,and
R6564 T9971 T9970 arg2Of ABIN,(
R6565 T9972 T9970 arg3Of ),(
R6566 T9974 T9968 arg2Of and,of
R6567 T9976 T9974 arg2Of protein,and
R6568 T9976 T9975 arg1Of protein,Tax1-binding
R6569 T9976 T9977 arg1Of protein,1
R6570 T9976 T9978 arg1Of protein,[
R6571 T9979 T9978 arg2Of 43-46,[
R6572 T9980 T9978 arg3Of ],[
R6573 T9981 T9982 arg1Of Next,to
R6574 T9984 T9982 arg2Of role,to
R6575 T9984 T9983 arg1Of role,its
R6576 T9984 T9985 arg1Of role,in
R6577 T9986 T9985 arg2Of suppressing,in
R6578 T9988 T9986 arg2Of activation,suppressing
R6579 T9988 T9987 arg1Of activation,NF-κB
R6580 T9990 T9991 arg1Of A20,is
R6581 T9991 T9981 arg1Of is,Next
R6582 T9991 T9989 arg1Of is,","
R6583 T9991 T9992 arg1Of is,also
R6584 T9991 T9998 arg1Of is,","
R6585 T9991 T10001 arg1Of is,in
R6586 T9995 T9991 arg2Of inhibitor,is
R6587 T9995 T9993 arg1Of inhibitor,a
R6588 T9995 T9994 arg1Of inhibitor,strong
R6589 T9995 T9996 arg1Of inhibitor,of
R6590 T9997 T9996 arg2Of apoptosis,of
R6591 T10000 T9999 arg1Of least,at
R6592 T10001 T10000 arg1Of in,least
R6593 T10004 T10001 arg2Of types,in
R6594 T10004 T10002 arg1Of types,some
R6595 T10004 T10003 arg1Of types,cell
R6596 T10006 T10005 arg1Of mechanisms,The
R6597 T10006 T10007 arg2Of mechanisms,by
R6598 T10006 T10008 arg1Of mechanisms,which
R6599 T10006 T10016 arg1Of mechanisms,are
R66 T69 T70 arg1Of termination,of
R6600 T10006 T10018 arg1Of mechanisms,elusive
R6601 T10009 T10010 arg1Of A20,regulates
R6602 T10010 T10007 arg1Of regulates,by
R6603 T10012 T10010 arg2Of signalling,regulates
R6604 T10012 T10011 arg1Of signalling,apoptotic
R6605 T10016 T10013 arg1Of are,","
R6606 T10016 T10014 arg1Of are,however
R6607 T10016 T10015 arg1Of are,","
R6608 T10016 T10017 arg1Of are,still
R6609 T10018 T10016 arg2Of elusive,are
R6610 T10020 T10019 arg1Of mice,A20-deficient
R6611 T10020 T10022 arg1Of mice,develop
R6612 T10020 T10028 arg1Of mice,die
R6613 T10020 T10035 arg1Of mice,illustrating
R6614 T10022 T10027 arg1Of develop,and
R6615 T10024 T10025 arg1Of inflammation,and
R6616 T10025 T10022 arg2Of and,develop
R6617 T10025 T10023 arg1Of and,multiorgan
R6618 T10026 T10025 arg2Of cachexia,and
R6619 T10027 T10034 arg1Of and,","
R6620 T10028 T10027 arg2Of die,and
R6621 T10028 T10029 arg1Of die,within
R6622 T10031 T10029 arg2Of weeks,within
R6623 T10031 T10030 arg1Of weeks,2
R6624 T10031 T10032 arg1Of weeks,of
R6625 T10033 T10032 arg2Of birth,of
R6626 T10034 T10021 arg1Of ",",spontaneously
R6627 T10034 T10043 arg1Of ",",[
R6628 T10035 T10034 arg2Of illustrating,","
R6629 T10039 T10035 arg2Of function,illustrating
R6630 T10039 T10036 arg1Of function,the
R6631 T10039 T10037 arg1Of function,potent
R6632 T10039 T10038 arg1Of function,anti-inflammatory
R6633 T10039 T10040 arg1Of function,of
R6634 T10042 T10040 arg2Of molecule,of
R6635 T10042 T10041 arg1Of molecule,this
R6636 T10044 T10043 arg2Of 46,[
R6637 T10045 T10043 arg3Of ],[
R6638 T10047 T10046 arg1Of cells,A20-deficient
R6639 T10047 T10048 arg1Of cells,are
R6640 T10047 T10051 arg1Of cells,susceptible
R6641 T10048 T10049 arg1Of are,also
R6642 T10048 T10055 arg1Of are,","
R6643 T10048 T10056 modOf are,confirming
R6644 T10051 T10048 arg2Of susceptible,are
R6645 T10051 T10050 arg1Of susceptible,more
R6646 T10051 T10052 arg1Of susceptible,to
R6647 T10054 T10052 arg2Of apoptosis,to
R6648 T10054 T10053 arg1Of apoptosis,TNF-mediated
R6649 T10058 T10056 arg2Of role,confirming
R6650 T10058 T10057 arg1Of role,its
R6651 T10058 T10059 arg1Of role,as
R6652 T10062 T10059 arg2Of protein,as
R6653 T10062 T10060 arg1Of protein,an
R6654 T10062 T10061 arg1Of protein,antiapoptotic
R6655 T10063 T10065 arg1Of We,showed
R6656 T10065 T10064 arg1Of showed,recently
R6657 T10067 T10069 arg1Of mice,lacking
R6658 T10067 T10075 arg1Of mice,exhibit
R6659 T10069 T10068 arg1Of lacking,specifically
R6660 T10069 T10071 arg1Of lacking,in
R6661 T10070 T10069 arg2Of A20,lacking
R6662 T10074 T10071 arg2Of cells,in
R6663 T10074 T10072 arg1Of cells,intestinal
R6664 T10074 T10073 arg1Of cells,epithelial
R6665 T10075 T10065 arg2Of exhibit,showed
R6666 T10075 T10066 arg1Of exhibit,that
R6667 T10075 T10093 arg1Of exhibit,","
R6668 T10075 T10094 modOf exhibit,confirming
R6669 T10077 T10075 arg2Of susceptibility,exhibit
R6670 T10077 T10076 arg2Of susceptibility,increased
R6671 T10077 T10078 arg1Of susceptibility,to
R6672 T10077 T10082 arg1Of susceptibility,to
R6673 T10080 T10078 arg2Of colitis,to
R6674 T10080 T10079 arg1Of colitis,experimental
R6675 T10082 T10081 arg1Of to,due
R6676 T10084 T10082 arg2Of hypersensitivity,to
R6677 T10084 T10083 arg1Of hypersensitivity,the
R6678 T10084 T10085 arg1Of hypersensitivity,of
R6679 T10084 T10090 arg1Of hypersensitivity,to
R6680 T10089 T10085 arg2Of cells,of
R6681 T10089 T10086 arg1Of cells,their
R6682 T10089 T10087 arg1Of cells,intestinal
R6683 T10089 T10088 arg1Of cells,epithelial
R6684 T10092 T10090 arg2Of apoptosis,to
R6685 T10092 T10091 arg1Of apoptosis,TNF-induced
R6686 T10094 T10096 arg1Of confirming,as
R6687 T10094 T10105 arg1Of confirming,[
R6688 T10095 T10094 arg2Of A20,confirming
R6689 T10100 T10096 arg2Of protein,as
R6690 T10100 T10097 arg1Of protein,a
R6691 T10100 T10098 arg1Of protein,major
R6692 T10100 T10099 arg1Of protein,antiapoptotic
R6693 T10100 T10101 arg1Of protein,in
R6694 T10104 T10101 arg2Of epithelium,in
R6695 T10104 T10102 arg1Of epithelium,the
R6696 T10104 T10103 arg1Of epithelium,intestinal
R6697 T10106 T10105 arg2Of 47,[
R6698 T10107 T10105 arg3Of ],[
R6699 T10110 T10108 arg1Of studies,Two
R67 T72 T70 arg2Of responses,of
R6700 T10110 T10109 arg1Of studies,independent
R6701 T10110 T10111 arg1Of studies,showed
R6702 T10113 T10114 arg1Of mice,lacking
R6703 T10113 T10119 arg1Of mice,develop
R6704 T10114 T10116 arg1Of lacking,in
R6705 T10115 T10114 arg2Of A20,lacking
R6706 T10118 T10116 arg2Of cells,in
R6707 T10118 T10117 arg1Of cells,B
R6708 T10119 T10111 arg2Of develop,showed
R6709 T10119 T10112 arg1Of develop,that
R6710 T10119 T10122 arg1Of develop,to
R6711 T10120 T10119 arg2Of autoimmunity,develop
R6712 T10122 T10121 arg1Of to,due
R6713 T10125 T10122 arg2Of responses,to
R6714 T10125 T10123 arg1Of responses,hyperactive
R6715 T10125 T10124 arg1Of responses,NF-κB
R6716 T10125 T10126 arg1Of responses,in
R6717 T10128 T10126 arg2Of cells,in
R6718 T10128 T10127 arg1Of cells,B
R6719 T10128 T10129 arg1Of cells,leading
R6720 T10129 T10130 arg1Of leading,to
R6721 T10133 T10130 arg2Of survival,to
R6722 T10133 T10131 arg1Of survival,unrestricted
R6723 T10133 T10132 arg1Of survival,B-cell
R6724 T10133 T10134 arg1Of survival,[
R6725 T10135 T10134 arg2Of "48,49",[
R6726 T10136 T10134 arg3Of ],[
R6727 T10138 T10137 arg1Of expression,A20
R6728 T10138 T10139 arg1Of expression,has
R6729 T10138 T10140 arg1Of expression,been
R6730 T10138 T10141 arg2Of expression,observed
R6731 T10141 T10139 arg2Of observed,has
R6732 T10141 T10140 arg2Of observed,been
R6733 T10141 T10142 arg1Of observed,in
R6734 T10145 T10142 arg2Of types,in
R6735 T10145 T10143 arg1Of types,several
R6736 T10145 T10144 arg1Of types,cell
R6737 T10145 T10146 arg1Of types,that
R6738 T10145 T10147 arg1Of types,play
R6739 T10145 T10155 arg1Of types,","
R6740 T10145 T10157 arg1Of types,as
R6741 T10147 T10150 arg1Of play,in
R6742 T10149 T10147 arg2Of roles,play
R6743 T10149 T10148 arg1Of roles,important
R6744 T10152 T10150 arg2Of pathophysiology,in
R6745 T10152 T10151 arg1Of pathophysiology,the
R6746 T10152 T10153 arg1Of pathophysiology,of
R6747 T10154 T10153 arg2Of RA,of
R6748 T10157 T10156 arg1Of as,such
R6749 T10158 T10159 arg1Of fibroblasts,","
R6750 T10159 T10161 arg1Of ",",and
R6751 T10160 T10159 arg2Of synoviocytes,","
R6752 T10161 T10157 arg2Of and,as
R6753 T10162 T10161 arg2Of lymphocytes,and
R6754 T10166 T10165 arg1Of expression,A20
R6755 T10166 T10167 arg1Of expression,is
R6756 T10166 T10169 arg2Of expression,regulated
R6757 T10166 T10176 arg1Of expression,implicating
R6758 T10169 T10163 arg1Of regulated,Interestingly
R6759 T10169 T10164 arg1Of regulated,","
R6760 T10169 T10167 arg2Of regulated,is
R6761 T10169 T10168 arg1Of regulated,itself
R6762 T10169 T10175 arg1Of regulated,","
R6763 T10169 T10176 modOf regulated,implicating
R6764 T10171 T10169 arg1Of NF-κB,regulated
R6765 T10171 T10170 arg2Of NF-κB,by
R6766 T10171 T10172 arg1Of NF-κB,[
R6767 T10173 T10172 arg2Of 50,[
R6768 T10174 T10172 arg3Of ],[
R6769 T10176 T10178 arg1Of implicating,in
R6770 T10177 T10176 arg2Of A20,implicating
R6771 T10182 T10178 arg2Of regulation,in
R6772 T10182 T10179 arg1Of regulation,the
R6773 T10182 T10180 arg1Of regulation,negative
R6774 T10182 T10181 arg1Of regulation,feedback
R6775 T10182 T10183 arg1Of regulation,of
R6776 T10185 T10183 arg2Of signalling,of
R6777 T10185 T10184 arg1Of signalling,NF-κB
R6778 T10189 T10188 arg1Of injection,intra-articular
R6779 T10189 T10190 arg1Of injection,of
R6780 T10189 T10194 arg1Of injection,was
R6781 T10189 T10195 arg2Of injection,shown
R6782 T10189 T10197 arg1Of injection,reduce
R6783 T10193 T10190 arg2Of adenovirus,of
R6784 T10193 T10191 arg1Of adenovirus,an
R6785 T10193 T10192 arg1Of adenovirus,A20-expressing
R6786 T10195 T10186 arg1Of shown,Recently
R6787 T10195 T10187 arg1Of shown,","
R6788 T10195 T10194 arg2Of shown,was
R6789 T10197 T10195 arg3Of reduce,shown
R6790 T10197 T10196 arg1Of reduce,to
R6791 T10197 T10206 arg1Of reduce,in
R6792 T10197 T10213 arg1Of reduce,","
R6793 T10197 T10215 arg1Of reduce,in
R6794 T10197 T10218 arg1Of reduce,","
R6795 T10197 T10219 arg1Of reduce,in
R6796 T10199 T10197 arg2Of severity,reduce
R6797 T10199 T10198 arg1Of severity,the
R6798 T10199 T10200 arg1Of severity,of
R6799 T10202 T10201 arg1Of inflammation,synovial
R68 T72 T71 arg1Of responses,NF-κB
R6800 T10202 T10203 arg1Of inflammation,and
R6801 T10203 T10200 arg2Of and,of
R6802 T10205 T10203 arg2Of destruction,and
R6803 T10205 T10204 arg1Of destruction,joint
R6804 T10209 T10206 arg2Of model,in
R6805 T10209 T10207 arg1Of model,a
R6806 T10209 T10208 arg1Of model,mouse
R6807 T10209 T10210 arg1Of model,of
R6808 T10212 T10210 arg2Of arthritis,of
R6809 T10212 T10211 arg1Of arthritis,collagen-induced
R6810 T10215 T10214 arg1Of in,even
R6811 T10217 T10215 arg2Of joints,in
R6812 T10217 T10216 arg1Of joints,untreated
R6813 T10222 T10223 arg1Of prophylactic,and
R6814 T10224 T10223 arg2Of therapeutic,and
R6815 T10225 T10219 arg2Of setting,in
R6816 T10225 T10220 arg1Of setting,both
R6817 T10225 T10221 arg1Of setting,a
R6818 T10225 T10222 arg1Of setting,prophylactic
R6819 T10225 T10224 arg1Of setting,therapeutic
R6820 T10227 T10226 arg1Of expression,A20
R6821 T10227 T10228 arg1Of expression,in
R6822 T10227 T10231 arg1Of expression,was
R6823 T10227 T10232 arg2Of expression,associated
R6824 T10230 T10228 arg2Of tissue,in
R6825 T10230 T10229 arg1Of tissue,synovial
R6826 T10232 T10231 arg2Of associated,was
R6827 T10232 T10233 arg1Of associated,with
R6828 T10232 T10258 arg1Of associated,","
R6829 T10232 T10259 modOf associated,suggesting
R6830 T10234 T10233 arg2Of inhibition,with
R6831 T10234 T10235 arg1Of inhibition,of
R6832 T10234 T10241 arg1Of inhibition,of
R6833 T10237 T10236 arg1Of activity,NF-κB
R6834 T10237 T10238 arg1Of activity,and
R6835 T10238 T10235 arg2Of and,of
R6836 T10240 T10238 arg2Of levels,and
R6837 T10240 T10239 arg2Of levels,decreased
R6838 T10242 T10243 arg1Of TNF,","
R6839 T10243 T10245 arg1Of ",",","
R6840 T10244 T10243 arg2Of IL-1β,","
R6841 T10245 T10247 arg1Of ",",","
R6842 T10246 T10245 arg2Of IL-6,","
R6843 T10247 T10250 arg1Of ",",","
R6844 T10249 T10247 arg2Of RANKL,","
R6845 T10249 T10248 arg1Of RANKL,soluble
R6846 T10250 T10256 arg1Of ",",and
R6847 T10253 T10250 arg2Of protein,","
R6848 T10253 T10251 arg1Of protein,monocyte
R6849 T10253 T10252 arg1Of protein,chemo-attractant
R6850 T10253 T10254 arg1Of protein,1
R6851 T10256 T10241 arg2Of and,of
R6852 T10256 T10255 arg1Of and,","
R6853 T10257 T10256 arg2Of IL-17,and
R6854 T10261 T10262 arg1Of A20,induces
R6855 T10262 T10259 arg2Of induces,suggesting
R6856 T10262 T10260 arg1Of induces,that
R6857 T10262 T10266 arg1Of induces,in
R6858 T10262 T10270 arg1Of induces,through
R6859 T10262 T10280 arg1Of induces,[
R6860 T10265 T10262 arg2Of effect,induces
R6861 T10265 T10263 arg1Of effect,a
R6862 T10265 T10264 arg1Of effect,protective
R6863 T10269 T10266 arg2Of mice,in
R6864 T10269 T10267 arg1Of mice,collagen-induced
R6865 T10269 T10268 arg1Of mice,arthritis
R6866 T10271 T10272 arg1Of suppression,of
R6867 T10271 T10275 arg1Of suppression,and
R6868 T10274 T10272 arg2Of activation,of
R6869 T10274 T10273 arg1Of activation,NF-κB
R6870 T10275 T10270 arg2Of and,through
R6871 T10279 T10275 arg2Of expression,and
R6872 T10279 T10276 arg1Of expression,NF-
R6873 T10279 T10277 arg1Of expression,κB-dependent
R6874 T10279 T10278 arg1Of expression,gene
R6875 T10281 T10280 arg2Of 51,[
R6876 T10282 T10280 arg3Of ],[
R6877 T10284 T10285 arg1Of TNF,and
R6878 T10285 T10287 arg1Of and,are
R6879 T10285 T10288 arg2Of and,known
R6880 T10285 T10290 arg1Of and,mediate
R6881 T10286 T10285 arg2Of IL-1β,and
R6882 T10288 T10283 arg2Of known,Because
R6883 T10288 T10287 arg2Of known,are
R6884 T10290 T10288 arg3Of mediate,known
R6885 T10290 T10289 arg1Of mediate,to
R6886 T10291 T10292 arg1Of synovitis,","
R6887 T10292 T10296 arg1Of ",",and
R6888 T10294 T10292 arg2Of formation,","
R6889 T10294 T10293 arg1Of formation,pannus
R6890 T10296 T10290 arg2Of and,mediate
R6891 T10296 T10295 arg1Of and,","
R6892 T10296 T10298 arg1Of and,of
R6893 T10297 T10296 arg2Of erosion,and
R6894 T10299 T10300 arg1Of cartilage,and
R6895 T10300 T10298 arg2Of and,of
R6896 T10300 T10302 arg1Of and,in
R6897 T10301 T10300 arg2Of bone,and
R6898 T10303 T10302 arg2Of RA,in
R6899 T10308 T10305 arg1Of levels,the
R69 T74 T75 arg1Of we,will
R6900 T10308 T10306 arg2Of levels,decreased
R6901 T10308 T10307 arg1Of levels,serum
R6902 T10308 T10309 arg1Of levels,of
R6903 T10308 T10316 arg1Of levels,might
R6904 T10308 T10317 arg1Of levels,explain
R6905 T10310 T10311 arg1Of TNF,and
R6906 T10311 T10309 arg2Of and,of
R6907 T10311 T10313 arg1Of and,in
R6908 T10312 T10311 arg2Of IL-1β,and
R6909 T10315 T10313 arg2Of mice,in
R6910 T10315 T10314 arg1Of mice,A20-transduced
R6911 T10317 T10283 arg1Of explain,Because
R6912 T10317 T10304 arg1Of explain,","
R6913 T10317 T10316 arg2Of explain,might
R6914 T10317 T10321 arg1Of explain,in
R6915 T10320 T10317 arg2Of effects,explain
R6916 T10320 T10318 arg1Of effects,the
R6917 T10320 T10319 arg1Of effects,beneficial
R6918 T10323 T10324 arg1Of clinical,","
R6919 T10324 T10327 arg1Of ",",and
R6920 T10325 T10324 arg2Of pathological,","
R6921 T10327 T10326 arg1Of and,","
R6922 T10328 T10327 arg2Of radiological,and
R6923 T10329 T10321 arg2Of findings,in
R6924 T10329 T10322 arg1Of findings,the
R6925 T10329 T10323 arg1Of findings,clinical
R6926 T10329 T10325 arg1Of findings,pathological
R6927 T10329 T10328 arg1Of findings,radiological
R6928 T10331 T10330 arg1Of study,This
R6929 T10331 T10333 arg1Of study,demonstrated
R6930 T10333 T10332 arg1Of demonstrated,also
R6931 T10336 T10335 arg1Of overexpression,A20
R6932 T10336 T10337 arg1Of overexpression,leads
R6933 T10337 T10333 arg2Of leads,demonstrated
R6934 T10337 T10334 arg1Of leads,that
R6935 T10337 T10338 arg1Of leads,to
R6936 T10340 T10338 arg2Of decrease,to
R6937 T10340 T10339 arg1Of decrease,a
R6938 T10340 T10341 arg1Of decrease,in
R6939 T10343 T10341 arg2Of number,in
R6940 T10343 T10342 arg1Of number,the
R6941 T10343 T10344 arg1Of number,of
R6942 T10343 T10347 arg1Of number,in
R6943 T10346 T10344 arg2Of osteoclasts,of
R6944 T10346 T10345 arg2Of osteoclasts,activated
R6945 T10349 T10347 arg2Of tissue,in
R6946 T10349 T10348 arg1Of tissue,joint
R6947 T10350 T10351 arg1Of A20,might
R6948 T10350 T10353 arg1Of A20,minimise
R6949 T10350 T10357 arg1Of A20,decreasing
R6950 T10353 T10351 arg2Of minimise,might
R6951 T10353 T10352 arg1Of minimise,therefore
R6952 T10353 T10356 arg1Of minimise,through
R6953 T10355 T10353 arg2Of destruction,minimise
R6954 T10355 T10354 arg1Of destruction,joint
R6955 T10357 T10356 arg2Of decreasing,through
R6956 T10360 T10361 arg1Of number,and
R6957 T10361 T10357 arg2Of and,decreasing
R6958 T10361 T10358 arg1Of and,the
R6959 T10361 T10359 arg1Of and,osteoclast
R6960 T10362 T10361 arg2Of activity,and
R6961 T10365 T10364 arg2Of be,will
R6962 T10366 T10365 arg2Of interesting,be
R6963 T10368 T10363 arg1Of analyse,It
R6964 T10368 T10364 arg1Of analyse,will
R6965 T10368 T10365 arg1Of analyse,be
R6966 T10368 T10366 arg1Of analyse,interesting
R6967 T10368 T10367 arg1Of analyse,to
R6968 T10368 T10369 arg1Of analyse,in
R6969 T10370 T10375 arg1Of future,knockout
R6970 T10375 T10371 arg1Of knockout,the
R6971 T10375 T10372 arg1Of knockout,susceptibility
R6972 T10375 T10373 arg1Of knockout,of
R6973 T10375 T10374 arg1Of knockout,conditional
R6974 T10376 T10369 arg2Of mice,in
R6975 T10376 T10370 arg1Of mice,future
R6976 T10377 T10368 arg2Of that,analyse
R6977 T10377 T10378 arg1Of that,lack
R6978 T10378 T10380 arg1Of lack,in
R6979 T10379 T10378 arg2Of A20,lack
R6980 T10383 T10381 arg1Of types,specific
R6981 T10383 T10382 arg1Of types,cell
R6982 T10383 T10385 arg1Of types,as
R6983 T10383 T10393 arg1Of types,","
R6984 T10385 T10384 arg1Of as,such
R6985 T10387 T10386 arg1Of fibroblasts,synovial
R6986 T10387 T10388 arg1Of fibroblasts,","
R6987 T10388 T10390 arg1Of ",",","
R6988 T10389 T10388 arg2Of macrophages,","
R6989 T10390 T10385 arg2Of ",",as
R6990 T10392 T10390 arg2Of cells,","
R6991 T10392 T10391 arg1Of cells,dendritic
R6992 T10393 T10396 arg1Of ",",or
R6993 T10395 T10393 arg2Of cells,","
R6994 T10395 T10394 arg1Of cells,B
R6995 T10396 T10380 arg2Of or,in
R6996 T10398 T10396 arg2Of cells,or
R6997 T10398 T10397 arg1Of cells,T
R6998 T10402 T10401 arg1Of SNPs,several
R6999 T10402 T10403 arg1Of SNPs,in
R7 T11 T12 arg1Of involvement,in
R70 T74 T76 arg1Of we,review
R7000 T10402 T10408 arg1Of SNPs,have
R7001 T10402 T10409 arg1Of SNPs,been
R7002 T10402 T10410 arg2Of SNPs,associated
R7003 T10407 T10403 arg2Of locus,in
R7004 T10407 T10404 arg1Of locus,the
R7005 T10407 T10405 arg1Of locus,human
R7006 T10407 T10406 arg1Of locus,A20
R7007 T10410 T10399 arg1Of associated,Importantly
R7008 T10410 T10400 arg1Of associated,","
R7009 T10410 T10408 arg2Of associated,have
R7010 T10410 T10409 arg2Of associated,been
R7011 T10410 T10411 arg1Of associated,with
R7012 T10413 T10411 arg2Of susceptibility,with
R7013 T10413 T10412 arg2Of susceptibility,increased
R7014 T10413 T10414 arg1Of susceptibility,to
R7015 T10415 T10414 arg2Of development,to
R7016 T10415 T10416 arg1Of development,of
R7017 T10415 T10419 arg1Of development,(
R7018 T10418 T10416 arg2Of pathologies,of
R7019 T10418 T10417 arg1Of pathologies,autoimmune
R7020 T10420 T10419 arg2Of reviewed,(
R7021 T10420 T10421 arg1Of reviewed,in
R7022 T10420 T10422 arg1Of reviewed,[
R7023 T10423 T10422 arg2Of 52,[
R7024 T10424 T10422 arg3Of ],[
R7025 T10425 T10419 arg3Of ),(
R7026 T10429 T10426 arg1Of studies,Several
R7027 T10429 T10427 arg1Of studies,genome-wide
R7028 T10429 T10428 arg1Of studies,association
R7029 T10429 T10431 arg1Of studies,revealed
R7030 T10431 T10430 arg1Of revealed,also
R7031 T10434 T10432 arg1Of association,a
R7032 T10434 T10433 arg1Of association,clear
R7033 T10434 T10435 arg1Of association,between
R7034 T10434 T10445 arg1Of association,and
R7035 T10436 T10435 arg2Of mutations,between
R7036 T10436 T10437 arg1Of mutations,in
R7037 T10440 T10437 arg2Of locus,in
R7038 T10440 T10438 arg1Of locus,the
R7039 T10440 T10439 arg1Of locus,A20
R7040 T10440 T10441 arg1Of locus,in
R7041 T10444 T10441 arg2Of chromosome,in
R7042 T10444 T10442 arg1Of chromosome,the
R7043 T10444 T10443 arg1Of chromosome,6q23
R7044 T10445 T10431 arg2Of and,revealed
R7045 T10446 T10445 arg2Of susceptibility,and
R7046 T10446 T10447 arg1Of susceptibility,to
R7047 T10448 T10447 arg2Of RA,to
R7048 T10448 T10449 arg1Of RA,[
R7049 T10450 T10449 arg2Of 52,[
R7050 T10451 T10449 arg3Of ],[
R7051 T10455 T10453 arg1Of variants,the
R7052 T10455 T10454 arg2Of variants,identified
R7053 T10455 T10456 arg1Of variants,are
R7054 T10455 T10458 arg2Of variants,located
R7055 T10458 T10452 arg2Of located,Although
R7056 T10458 T10456 arg2Of located,are
R7057 T10458 T10457 arg1Of located,not
R7058 T10458 T10459 arg1Of located,in
R7059 T10461 T10459 arg2Of gene,in
R7060 T10461 T10460 arg1Of gene,a
R7061 T10463 T10464 arg1Of they,are
R7062 T10463 T10465 arg2Of they,thought
R7063 T10463 T10467 arg1Of they,influence
R7064 T10465 T10452 arg1Of thought,Although
R7065 T10465 T10462 arg1Of thought,","
R7066 T10465 T10464 arg2Of thought,are
R7067 T10467 T10465 arg3Of influence,thought
R7068 T10467 T10466 arg1Of influence,to
R7069 T10467 T10469 arg1Of influence,as
R7070 T10467 T10480 arg1Of influence,","
R7071 T10467 T10482 arg1Of influence,by
R7072 T10468 T10467 arg2Of A20,influence
R7073 T10472 T10469 arg2Of gene,as
R7074 T10472 T10470 arg1Of gene,its
R7075 T10472 T10471 arg1Of gene,nearest
R7076 T10472 T10473 arg1Of gene,(
R7077 T10475 T10473 arg2Of kb,(
R7078 T10475 T10474 arg1Of kb,~150
R7079 T10475 T10476 arg1Of kb,downstream
R7080 T10476 T10477 arg1Of downstream,of
R7081 T10478 T10477 arg2Of A20,of
R7082 T10479 T10473 arg3Of ),(
R7083 T10482 T10481 arg1Of by,probably
R7084 T10484 T10482 arg2Of presence,by
R7085 T10484 T10483 arg1Of presence,the
R7086 T10484 T10485 arg1Of presence,of
R7087 T10489 T10485 arg2Of elements,of
R7088 T10489 T10486 arg1Of elements,potential
R7089 T10489 T10487 arg1Of elements,regulatory
R7090 T10489 T10488 arg1Of elements,DNA
R7091 T10489 T10490 arg1Of elements,in
R7092 T10492 T10490 arg2Of region,in
R7093 T10492 T10491 arg1Of region,this
R7094 T10494 T10495 arg1Of A20,is
R7095 T10494 T10496 arg2Of A20,required
R7096 T10496 T10495 arg2Of required,is
R7097 T10496 T10497 arg1Of required,for
R7098 T10496 T10503 arg1Of required,and
R7099 T10498 T10497 arg2Of termination,for
R71 T76 T73 arg1Of review,Here
R7100 T10498 T10499 arg1Of termination,of
R7101 T10501 T10499 arg2Of signals,of
R7102 T10501 T10500 arg1Of signals,TNF-induced
R7103 T10503 T10493 arg2Of and,As
R7104 T10503 T10502 arg1Of and,","
R7105 T10504 T10505 arg1Of TNF,is
R7106 T10505 T10503 arg2Of is,and
R7107 T10509 T10505 arg2Of cytokine,is
R7108 T10509 T10506 arg1Of cytokine,the
R7109 T10509 T10507 arg1Of cytokine,primary
R7110 T10509 T10508 arg1Of cytokine,inflammatory
R7111 T10509 T10510 arg1Of cytokine,in
R7112 T10511 T10510 arg2Of RA,in
R7113 T10514 T10513 arg1Of findings,these
R7114 T10514 T10515 arg1Of findings,reveal
R7115 T10515 T10493 arg1Of reveal,As
R7116 T10515 T10512 arg1Of reveal,","
R7117 T10515 T10517 arg1Of reveal,as
R7118 T10516 T10515 arg2Of A20,reveal
R7119 T10521 T10517 arg2Of locus,as
R7120 T10521 T10518 arg1Of locus,a
R7121 T10521 T10519 arg1Of locus,candidate
R7122 T10521 T10520 arg1Of locus,susceptibility
R7123 T10521 T10522 arg1Of locus,for
R7124 T10523 T10522 arg2Of RA,for
R7125 T10526 T10525 arg1Of variants,these
R7126 T10526 T10527 arg1Of variants,affect
R7127 T10526 T10539 arg1Of variants,remain
R7128 T10526 T10540 arg1Of variants,unclear
R7129 T10527 T10536 arg1Of affect,","
R7130 T10530 T10528 arg1Of activity,normal
R7131 T10530 T10529 arg1Of activity,A20
R7132 T10530 T10531 arg1Of activity,and
R7133 T10531 T10527 arg2Of and,affect
R7134 T10532 T10531 arg2Of how,and
R7135 T10533 T10534 arg1Of they,cause
R7136 T10534 T10532 arg1Of cause,how
R7137 T10535 T10534 arg2Of RA,cause
R7138 T10536 T10524 arg1Of ",",How
R7139 T10539 T10536 arg2Of remain,","
R7140 T10539 T10537 arg1Of remain,however
R7141 T10539 T10538 arg1Of remain,","
R7142 T10540 T10539 arg2Of unclear,remain
R7143 T10543 T10544 arg1Of Elsby,and
R7144 T10544 T10547 arg1Of and,evaluated
R7145 T10544 T10563 arg1Of and,could
R7146 T10544 T10564 arg1Of and,show
R7147 T10545 T10544 arg2Of colleagues,and
R7148 T10547 T10549 arg1Of evaluated,vitro
R7149 T10547 T10562 arg1Of evaluated,and
R7150 T10549 T10548 arg1Of vitro,in
R7151 T10552 T10547 arg2Of ability,evaluated
R7152 T10552 T10550 arg1Of ability,the
R7153 T10552 T10551 arg1Of ability,regulatory
R7154 T10552 T10553 arg1Of ability,of
R7155 T10552 T10557 arg1Of ability,on
R7156 T10556 T10553 arg2Of variants,of
R7157 T10556 T10554 arg1Of variants,RA-associated
R7158 T10556 T10555 arg1Of variants,SNP
R7159 T10560 T10557 arg2Of activity,on
R7160 T10560 T10558 arg1Of activity,A20
R7161 T10560 T10559 arg1Of activity,promoter
R7162 T10562 T10541 arg1Of and,Recently
R7163 T10562 T10542 arg1Of and,","
R7164 T10562 T10546 arg1Of and,functionally
R7165 T10562 T10561 arg1Of and,","
R7166 T10564 T10562 arg2Of show,and
R7167 T10564 T10563 arg2Of show,could
R7168 T10567 T10564 arg2Of transcription,show
R7169 T10567 T10565 arg2Of transcription,repressed
R7170 T10567 T10566 arg1Of transcription,A20
R7171 T10567 T10568 arg1Of transcription,for
R7172 T10569 T10568 arg2Of some,for
R7173 T10569 T10570 arg1Of some,of
R7174 T10572 T10570 arg2Of SNPs,of
R7175 T10572 T10571 arg1Of SNPs,the
R7176 T10572 T10573 arg2Of SNPs,investigated
R7177 T10573 T10574 arg1Of investigated,[
R7178 T10575 T10574 arg2Of 53,[
R7179 T10576 T10574 arg3Of ],[
R7180 T10577 T10578 arg1Of It,will
R7181 T10577 T10579 arg1Of It,be
R7182 T10577 T10580 arg1Of It,of
R7183 T10579 T10578 arg2Of be,will
R7184 T10579 T10582 modOf be,to
R7185 T10579 T10589 modOf be,to
R7186 T10580 T10579 arg2Of of,be
R7187 T10581 T10580 arg2Of interest,of
R7188 T10583 T10582 arg1Of identify,to
R7189 T10583 T10588 arg1Of identify,and
R7190 T10587 T10583 arg2Of variants,identify
R7191 T10587 T10584 arg1Of variants,the
R7192 T10587 T10585 arg1Of variants,actual
R7193 T10587 T10586 arg1Of variants,causal
R7194 T10590 T10588 arg2Of elucidate,and
R7195 T10590 T10589 arg1Of elucidate,to
R7196 T10593 T10590 arg2Of consequences,elucidate
R7197 T10593 T10591 arg1Of consequences,the
R7198 T10593 T10592 arg1Of consequences,functional
R7199 T10593 T10594 arg1Of consequences,of
R72 T76 T75 arg2Of review,will
R7200 T10596 T10594 arg2Of variants,of
R7201 T10596 T10595 arg1Of variants,these
R7202 T10599 T10597 arg2Of context,In
R7203 T10599 T10598 arg1Of context,this
R7204 T10602 T10601 arg1Of mice,knockin
R7205 T10602 T10603 arg1Of mice,for
R7206 T10602 T10616 arg1Of mice,will
R7207 T10602 T10617 arg1Of mice,be
R7208 T10607 T10603 arg2Of SNPs,for
R7209 T10607 T10604 arg1Of SNPs,the
R7210 T10607 T10605 arg1Of SNPs,corresponding
R7211 T10607 T10606 arg1Of SNPs,A20
R7212 T10607 T10608 arg1Of SNPs,","
R7213 T10607 T10609 arg2Of SNPs,combined
R7214 T10609 T10610 arg1Of combined,with
R7215 T10612 T10610 arg2Of models,with
R7216 T10612 T10611 arg1Of models,mouse
R7217 T10612 T10613 arg1Of models,for
R7218 T10614 T10613 arg2Of RA,for
R7219 T10617 T10597 arg1Of be,In
R7220 T10617 T10600 arg1Of be,","
R7221 T10617 T10615 arg1Of be,","
R7222 T10617 T10616 arg2Of be,will
R7223 T10619 T10618 arg1Of valuable,very
R7224 T10620 T10617 arg2Of tools,be
R7225 T10620 T10619 arg1Of tools,valuable
R73 T80 T76 arg2Of mechanisms,review
R74 T80 T77 arg1Of mechanisms,various
R75 T80 T78 arg1Of mechanisms,negative
R76 T80 T79 arg1Of mechanisms,regulatory
R77 T80 T81 arg1Of mechanisms,that
R78 T80 T82 arg1Of mechanisms,have
R79 T80 T83 arg1Of mechanisms,evolved
R8 T14 T12 arg2Of arthritis,in
R80 T80 T85 arg1Of mechanisms,control
R81 T80 T89 arg1Of mechanisms,which
R82 T80 T90 arg1Of mechanisms,have
R83 T80 T91 arg1Of mechanisms,been
R8366 T12738 T12737 arg1Of inhibitors,A20-binding
R8367 T12738 T12739 arg1Of inhibitors,of
R8368 T12740 T12739 arg2Of NF-κB,of
R8369 T12741 T12742 arg1Of ABIN-1,","
R8370 T12742 T12744 arg1Of ",",and
R8371 T12743 T12742 arg2Of ABIN-2,","
R8372 T12744 T12746 arg1Of and,(
R8373 T12744 T12757 arg1Of and,were
R8374 T12744 T12758 arg2Of and,identified
R8375 T12744 T12766 arg1Of and,were
R8376 T12744 T12767 arg2Of and,shown
R8377 T12744 T12769 arg1Of and,inhibit
R8378 T12745 T12744 arg2Of ABIN-3,and
R8379 T12748 T12746 arg2Of known,(
R8380 T12748 T12747 arg1Of known,also
R8381 T12748 T12749 arg1Of known,as
R8382 T12750 T12751 arg1Of TNIP-1,","
R8383 T12751 T12754 arg1Of ",",and
R8384 T12752 T12751 arg2Of TNIP-2,","
R8385 T12754 T12749 arg2Of and,as
R8386 T12754 T12753 arg1Of and,","
R8387 T12755 T12754 arg2Of TNIP-3,and
R8388 T12756 T12746 arg3Of ),(
R8389 T12758 T12757 arg2Of identified,were
R8390 T12758 T12759 arg1Of identified,as
R8391 T12758 T12765 arg1Of identified,and
R8392 T12761 T12760 arg1Of expressed,ubiquitously
R8393 T12764 T12759 arg2Of proteins,as
R8394 T12764 T12761 arg1Of proteins,expressed
R8395 T12764 T12762 arg1Of proteins,A20
R8396 T12764 T12763 arg1Of proteins,interacting
R8397 T12767 T12765 arg2Of shown,and
R8398 T12767 T12766 arg2Of shown,were
R8399 T12769 T12767 arg3Of inhibit,shown
R84 T80 T92 arg2Of mechanisms,implicated
R8400 T12769 T12768 arg1Of inhibit,to
R8401 T12771 T12769 arg2Of activation,inhibit
R8402 T12771 T12770 arg1Of activation,NF-κB
R8403 T12771 T12772 arg1Of activation,by
R8404 T12771 T12779 arg1Of activation,upon
R8405 T12773 T12774 arg1Of TNF,and
R8406 T12777 T12774 arg2Of inflammatory,and
R8407 T12777 T12775 arg1Of inflammatory,several
R8408 T12777 T12776 arg1Of inflammatory,other
R8409 T12778 T12772 arg2Of stimuli,by
R8410 T12778 T12773 arg1Of stimuli,TNF
R8411 T12778 T12777 arg1Of stimuli,inflammatory
R8412 T12780 T12779 arg2Of overexpression,upon
R8413 T12782 T12783 arg1Of ABINs,contain
R8414 T12783 T12781 arg2Of contain,Because
R8415 T12787 T12783 arg2Of motif,contain
R8416 T12787 T12784 arg1Of motif,a
R8417 T12787 T12785 arg1Of motif,specific
R8418 T12787 T12786 arg1Of motif,ubiquitin-binding
R8419 T12789 T12790 arg1Of they,have
R8420 T12789 T12791 arg1Of they,been
R8421 T12789 T12792 arg2Of they,proposed
R8422 T12789 T12794 arg1Of they,target
R8423 T12792 T12781 arg1Of proposed,Because
R8424 T12792 T12788 arg1Of proposed,","
R8425 T12792 T12790 arg2Of proposed,have
R8426 T12792 T12791 arg2Of proposed,been
R8427 T12794 T12792 arg3Of target,proposed
R8428 T12794 T12793 arg1Of target,to
R8429 T12795 T12794 arg2Of A20,target
R8430 T12795 T12796 arg1Of A20,to
R8431 T12798 T12796 arg2Of substrates,to
R8432 T12798 T12797 arg2Of substrates,polyubiquitinated
R8433 T12798 T12799 arg1Of substrates,[
R8434 T12800 T12799 arg2Of "43,44",[
R8435 T12801 T12799 arg3Of ],[
R8436 T12802 T12803 arg1Of Similar,to
R8437 T12804 T12803 arg2Of A20,to
R8438 T12806 T12807 arg1Of ABIN-1,and
R8439 T12807 T12810 arg1Of and,is
R8440 T12809 T12807 arg2Of expression,and
R8441 T12809 T12808 arg1Of expression,ABIN-3
R8442 T12810 T12802 arg1Of is,Similar
R8443 T12810 T12805 arg1Of is,","
R8444 T12810 T12813 arg1Of is,","
R8445 T12810 T12814 modOf is,implicating
R8446 T12811 T12810 arg2Of NF-κB,is
R8447 T12811 T12812 arg1Of NF-κB,dependent
R8448 T12817 T12814 arg2Of role,implicating
R8449 T12817 T12815 arg1Of role,a
R8450 T12817 T12816 arg1Of role,potential
R8451 T12817 T12818 arg1Of role,for
R8452 T12817 T12822 arg1Of role,in
R8453 T12821 T12818 arg2Of complex,for
R8454 T12821 T12819 arg1Of complex,the
R8455 T12821 T12820 arg1Of complex,A20/ABIN
R8456 T12826 T12822 arg2Of regulation,in
R8457 T12826 T12823 arg1Of regulation,the
R8458 T12826 T12824 arg1Of regulation,negative
R8459 T12826 T12825 arg1Of regulation,feedback
R8460 T12826 T12827 arg1Of regulation,of
R8461 T12826 T12830 arg1Of regulation,(
R8462 T12829 T12827 arg2Of activation,of
R8463 T12829 T12828 arg1Of activation,NF-κB
R8464 T12831 T12830 arg2Of reviewed,(
R8465 T12831 T12832 arg1Of reviewed,in
R8466 T12831 T12833 arg1Of reviewed,[
R8467 T12834 T12833 arg2Of 54,[
R8468 T12835 T12833 arg3Of ],[
R8469 T12836 T12830 arg3Of ),(
R8470 T12840 T12841 arg1Of ABIN-1-deficient,and
R8471 T12842 T12841 arg2Of ABIN-2-deficient,and
R8472 T12843 T12839 arg1Of mice,both
R8473 T12843 T12840 arg1Of mice,ABIN-1-deficient
R8474 T12843 T12842 arg1Of mice,ABIN-2-deficient
R8475 T12843 T12844 arg1Of mice,exhibit
R8476 T12843 T12856 arg1Of mice,reflecting
R8477 T12844 T12837 arg1Of exhibit,Unexpectedly
R8478 T12844 T12838 arg1Of exhibit,","
R8479 T12844 T12846 arg1Of exhibit,slightly
R8480 T12844 T12852 arg1Of exhibit,","
R8481 T12844 T12853 arg1Of exhibit,respectively
R8482 T12844 T12854 arg1Of exhibit,","
R8483 T12844 T12856 modOf exhibit,reflecting
R8484 T12846 T12845 arg1Of slightly,only
R8485 T12847 T12848 arg1Of increased,or
R8486 T12849 T12848 arg2Of normal,or
R8487 T12851 T12844 arg2Of responses,exhibit
R8488 T12851 T12847 arg1Of responses,increased
R8489 T12851 T12849 arg1Of responses,normal
R8490 T12851 T12850 arg1Of responses,NF-κB
R8491 T12856 T12855 arg1Of reflecting,possibly
R8492 T12860 T12856 arg2Of activities,reflecting
R8493 T12860 T12857 arg1Of activities,redundant
R8494 T12860 T12858 arg1Of activities,NF-κB
R8495 T12860 T12859 arg1Of activities,inhibitory
R8496 T12860 T12861 arg1Of activities,of
R8497 T12863 T12861 arg2Of ABINs,of
R8498 T12863 T12862 arg1Of ABINs,multiple
R8499 T12863 T12864 arg1Of ABINs,[
R85 T83 T82 arg2Of evolved,have
R8500 T12865 T12864 arg2Of "55,56",[
R8501 T12866 T12864 arg3Of ],[
R8502 T12868 T12867 arg1Of ABIN-3,Functional
R8503 T12868 T12869 arg1Of ABIN-3,is
R8504 T12868 T12870 arg2Of ABIN-3,expressed
R8505 T12870 T12869 arg2Of expressed,is
R8506 T12870 T12871 arg1Of expressed,in
R8507 T12870 T12874 arg1Of expressed,but
R8508 T12872 T12871 arg2Of humans,in
R8509 T12874 T12873 arg1Of but,","
R8510 T12875 T12877 arg1Of mice,express
R8511 T12877 T12874 arg2Of express,but
R8512 T12877 T12876 arg1Of express,only
R8513 T12879 T12880 arg1Of truncated,and
R8514 T12881 T12880 arg2Of inactive,and
R8515 T12882 T12877 arg2Of form,express
R8516 T12882 T12878 arg1Of form,a
R8517 T12882 T12879 arg1Of form,truncated
R8518 T12882 T12881 arg1Of form,inactive
R8519 T12882 T12883 arg1Of form,lacking
R8520 T12887 T12883 arg2Of domain,lacking
R8521 T12887 T12884 arg1Of domain,the
R8522 T12887 T12885 arg1Of domain,crucial
R8523 T12887 T12886 arg1Of domain,ubiquitin-binding
R8524 T12887 T12888 arg1Of domain,[
R8525 T12889 T12888 arg2Of 57,[
R8526 T12890 T12888 arg3Of ],[
R8527 T12892 T12891 arg1Of for,As
R8528 T12893 T12892 arg2Of A20,for
R8529 T12895 T12898 arg1Of ABIN-1,inhibits
R8530 T12898 T12896 arg1Of inhibits,also
R8531 T12898 T12897 arg1Of inhibits,strongly
R8532 T12898 T12905 arg1Of inhibits,and
R8533 T12900 T12898 arg2Of apoptosis,inhibits
R8534 T12900 T12899 arg1Of apoptosis,TNF-induced
R8535 T12900 T12901 arg1Of apoptosis,[
R8536 T12902 T12901 arg2Of 58,[
R8537 T12903 T12901 arg3Of ],[
R8538 T12905 T12892 arg1Of and,for
R8539 T12905 T12894 arg1Of and,","
R8540 T12905 T12904 arg1Of and,","
R8541 T12908 T12906 arg1Of mice,ABIN-1
R8542 T12908 T12907 arg1Of mice,deficient
R8543 T12908 T12909 arg1Of mice,die
R8544 T12909 T12905 arg2Of die,and
R8545 T12909 T12910 arg1Of die,embryonically
R8546 T12909 T12917 arg1Of die,[
R8547 T12910 T12912 arg1Of embryonically,to
R8548 T12912 T12911 arg1Of to,due
R8549 T12916 T12912 arg2Of apoptosis,to
R8550 T12916 T12913 arg1Of apoptosis,TNF-dependent
R8551 T12916 T12914 arg1Of apoptosis,foetal
R8552 T12916 T12915 arg1Of apoptosis,liver
R8553 T12918 T12917 arg2Of 56,[
R8554 T12919 T12917 arg3Of ],[
R8555 T12923 T12920 arg2Of analysis,Using
R8556 T12923 T12921 arg1Of analysis,oligonucleotide
R8557 T12923 T12922 arg1Of analysis,microarray
R8558 T12925 T12920 arg1Of ABIN-1,Using
R8559 T12925 T12926 arg1Of ABIN-1,was
R8560 T12925 T12927 arg2Of ABIN-1,identified
R8561 T12927 T12926 arg2Of identified,was
R8562 T12927 T12928 arg1Of identified,among
R8563 T12927 T12931 arg1Of identified,in
R8564 T12927 T12935 arg1Of identified,and
R8565 T12930 T12928 arg2Of genes,among
R8566 T12930 T12929 arg1Of genes,TNF-induced
R8567 T12933 T12931 arg2Of synoviocytes,in
R8568 T12933 T12932 arg1Of synoviocytes,human
R8569 T12935 T12920 modOf and,Using
R8570 T12935 T12924 arg1Of and,","
R8571 T12935 T12934 arg1Of and,","
R8572 T12937 T12936 arg1Of levels,high
R8573 T12937 T12938 arg1Of levels,of
R8574 T12937 T12941 arg1Of levels,were
R8575 T12937 T12942 arg2Of levels,detected
R8576 T12940 T12938 arg2Of mRNA,of
R8577 T12940 T12939 arg1Of mRNA,ABIN-1
R8578 T12942 T12935 arg2Of detected,and
R8579 T12942 T12941 arg2Of detected,were
R8580 T12942 T12943 arg1Of detected,in
R8581 T12942 T12947 arg1Of detected,","
R8582 T12942 T12948 modOf detected,indicating
R8583 T12946 T12943 arg2Of biopsies,in
R8584 T12946 T12944 arg1Of biopsies,RA
R8585 T12946 T12945 arg1Of biopsies,tissue
R8586 T12951 T12948 arg2Of role,indicating
R8587 T12951 T12949 arg1Of role,a
R8588 T12951 T12950 arg1Of role,potential
R8589 T12951 T12952 arg1Of role,for
R8590 T12951 T12956 arg1Of role,with
R8591 T12951 T12958 arg1Of role,","
R8592 T12951 T12959 arg1Of role,in
R8593 T12952 T12954 arg1Of for,","
R8594 T12953 T12952 arg2Of ABIN-1,for
R8595 T12956 T12954 arg2Of with,","
R8596 T12956 T12955 arg1Of with,together
R8597 T12957 T12956 arg2Of A20,with
R8598 T12963 T12960 arg1Of regulation,the
R8599 T12963 T12961 arg1Of regulation,negative
R86 T83 T88 arg1Of evolved,and
R8600 T12963 T12962 arg1Of regulation,feedback
R8601 T12963 T12964 arg1Of regulation,of
R8602 T12963 T12967 arg1Of regulation,and
R8603 T12966 T12964 arg2Of signalling,of
R8604 T12966 T12965 arg1Of signalling,NF-κB
R8605 T12967 T12959 arg2Of and,in
R8606 T12969 T12967 arg2Of pathogenesis,and
R8607 T12969 T12968 arg1Of pathogenesis,the
R8608 T12969 T12970 arg1Of pathogenesis,of
R8609 T12971 T12970 arg2Of RA,of
R8610 T12971 T12972 arg1Of RA,[
R8611 T12973 T12972 arg2Of 59,[
R8612 T12974 T12972 arg3Of ],[
R8613 T12978 T12975 arg2Of study,In
R8614 T12978 T12976 arg1Of study,a
R8615 T12978 T12977 arg1Of study,recent
R8616 T12980 T12981 arg1Of inhibition,of
R8617 T12980 T12984 arg1Of inhibition,by
R8618 T12980 T12994 arg1Of inhibition,was
R8619 T12980 T12995 arg2Of inhibition,shown
R8620 T12980 T12997 arg1Of inhibition,depend
R8621 T12983 T12981 arg2Of responses,of
R8622 T12983 T12982 arg1Of responses,TLR
R8623 T12990 T12989 arg2Of ITAM,(
R8624 T12991 T12989 arg3Of ),(
R8625 T12993 T12984 arg2Of receptors,by
R8626 T12993 T12985 arg1Of receptors,immunoreceptor
R8627 T12993 T12986 arg1Of receptors,tyrosine-based
R8628 T12993 T12987 arg1Of receptors,activation
R8629 T12993 T12988 arg1Of receptors,motif
R8630 T12993 T12989 arg1Of receptors,(
R8631 T12993 T12992 arg1Of receptors,-coupled
R8632 T12995 T12975 arg1Of shown,In
R8633 T12995 T12979 arg1Of shown,","
R8634 T12995 T12994 arg2Of shown,was
R8635 T12997 T12995 arg3Of depend,shown
R8636 T12997 T12996 arg1Of depend,to
R8637 T12997 T12998 arg1Of depend,on
R8638 T13000 T12998 arg2Of expression,on
R8639 T13000 T12999 arg1Of expression,the
R8640 T13000 T13001 arg1Of expression,of
R8641 T13005 T13002 arg1Of proteins,the
R8642 T13005 T13003 arg1Of proteins,NF-κB
R8643 T13005 T13004 arg1Of proteins,inhibitory
R8644 T13006 T13007 arg1Of ABIN-3,and
R8645 T13007 T13001 arg2Of and,of
R8646 T13007 T13005 arg1Of and,proteins
R8647 T13008 T13007 arg2Of A20,and
R8648 T13013 T13011 arg1Of effect,this
R8649 T13013 T13012 arg1Of effect,protective
R8650 T13013 T13014 arg1Of effect,of
R8651 T13013 T13017 arg1Of effect,was
R8652 T13013 T13019 arg2Of effect,suppressed
R8653 T13016 T13014 arg2Of ITAM,of
R8654 T13016 T13015 arg1Of ITAM,the
R8655 T13019 T13009 arg1Of suppressed,Moreover
R8656 T13019 T13010 arg1Of suppressed,","
R8657 T13019 T13017 arg2Of suppressed,was
R8658 T13019 T13018 arg1Of suppressed,strongly
R8659 T13019 T13020 arg1Of suppressed,in
R8660 T13024 T13020 arg2Of macrophages,in
R8661 T13024 T13021 arg1Of macrophages,inflammatory
R8662 T13024 T13022 arg1Of macrophages,arthritis
R8663 T13024 T13023 arg1Of macrophages,synovial
R8664 T13024 T13025 arg1Of macrophages,[
R8665 T13026 T13025 arg2Of 60,[
R8666 T13027 T13025 arg3Of ],[
R8667 T13031 T13030 arg1Of polymorphisms,ABIN-1
R8668 T13031 T13032 arg1Of polymorphisms,have
R8669 T13031 T13033 arg1Of polymorphisms,been
R8670 T13031 T13034 arg2Of polymorphisms,associated
R8671 T13034 T13028 arg1Of associated,Interestingly
R8672 T13034 T13029 arg1Of associated,","
R8673 T13034 T13032 arg2Of associated,have
R8674 T13034 T13033 arg2Of associated,been
R8675 T13034 T13035 arg1Of associated,with
R8676 T13036 T13037 arg1Of psoriasis,and
R8677 T13037 T13035 arg2Of and,with
R8678 T13037 T13041 arg1Of and,in
R8679 T13040 T13037 arg2Of erythematosus,and
R8680 T13040 T13038 arg1Of erythematosus,systemic
R8681 T13040 T13039 arg1Of erythematosus,lupus
R8682 T13042 T13041 arg2Of humans,in
R8683 T13042 T13043 arg1Of humans,[
R8684 T13044 T13043 arg2Of "61,62",[
R8685 T13045 T13043 arg3Of ],[
R8686 T13048 T13046 arg1Of degree,A
R8687 T13048 T13047 arg1Of degree,high
R8688 T13048 T13049 arg1Of degree,of
R8689 T13048 T13051 arg1Of degree,between
R8690 T13048 T13059 arg1Of degree,might
R8691 T13048 T13060 arg1Of degree,be
R8692 T13048 T13061 arg2Of degree,expected
R8693 T13050 T13049 arg2Of overlap,of
R8694 T13054 T13052 arg1Of erythematosus,systemic
R8695 T13054 T13053 arg1Of erythematosus,lupus
R8696 T13054 T13055 arg1Of erythematosus,and
R8697 T13055 T13051 arg2Of and,between
R8698 T13058 T13055 arg2Of loci,and
R8699 T13058 T13056 arg1Of loci,RA
R87 T85 T83 arg2Of control,evolved
R8700 T13058 T13057 arg1Of loci,susceptibility
R8701 T13061 T13059 arg2Of expected,might
R8702 T13061 T13060 arg2Of expected,be
R8703 T13061 T13062 arg1Of expected,as
R8704 T13065 T13063 arg1Of diseases,the
R8705 T13065 T13064 arg1Of diseases,two
R8706 T13065 T13066 arg1Of diseases,show
R8707 T13066 T13062 arg2Of show,as
R8708 T13066 T13070 arg1Of show,in
R8709 T13069 T13066 arg2Of overlap,show
R8710 T13069 T13067 arg1Of overlap,some
R8711 T13069 T13068 arg1Of overlap,clinical
R8712 T13072 T13071 arg1Of involvement,joint
R8713 T13072 T13073 arg1Of involvement,","
R8714 T13073 T13076 arg1Of ",",","
R8715 T13075 T13073 arg2Of production,","
R8716 T13075 T13074 arg1Of production,autoantibody
R8717 T13076 T13079 arg1Of ",",and
R8718 T13078 T13076 arg2Of features,","
R8719 T13078 T13077 arg1Of features,systemic
R8720 T13079 T13070 arg2Of and,in
R8721 T13080 T13079 arg2Of response,and
R8722 T13080 T13081 arg1Of response,to
R8723 T13082 T13081 arg2Of treatments,to
R8724 T13082 T13084 arg1Of treatments,as
R8725 T13084 T13083 arg1Of as,such
R8726 T13086 T13084 arg2Of depletion,as
R8727 T13086 T13085 arg1Of depletion,B-cell
R8728 T13086 T13087 arg1Of depletion,(
R8729 T13088 T13087 arg2Of rituximab,(
R8730 T13089 T13087 arg3Of ),(
R8731 T13093 T13091 arg2Of be,will
R8732 T13093 T13092 arg1Of be,therefore
R8733 T13094 T13093 arg2Of interesting,be
R8734 T13096 T13090 arg1Of investigate,It
R8735 T13096 T13091 arg1Of investigate,will
R8736 T13096 T13093 arg1Of investigate,be
R8737 T13096 T13094 arg1Of investigate,interesting
R8738 T13096 T13095 arg1Of investigate,to
R8739 T13098 T13099 arg1Of SNPs,that
R8740 T13098 T13100 arg1Of SNPs,have
R8741 T13098 T13101 arg1Of SNPs,been
R8742 T13098 T13102 arg2Of SNPs,reported
R8743 T13098 T13104 arg1Of SNPs,be
R8744 T13098 T13105 arg2Of SNPs,associated
R8745 T13098 T13110 arg1Of SNPs,are
R8746 T13098 T13112 arg2Of SNPs,associated
R8747 T13102 T13100 arg2Of reported,have
R8748 T13102 T13101 arg2Of reported,been
R8749 T13105 T13102 arg3Of associated,reported
R8750 T13105 T13103 arg1Of associated,to
R8751 T13105 T13104 arg2Of associated,be
R8752 T13105 T13106 arg1Of associated,with
R8753 T13109 T13106 arg2Of erythematosus,with
R8754 T13109 T13107 arg1Of erythematosus,systemic
R8755 T13109 T13108 arg1Of erythematosus,lupus
R8756 T13112 T13096 arg2Of associated,investigate
R8757 T13112 T13097 arg1Of associated,whether
R8758 T13112 T13110 arg2Of associated,are
R8759 T13112 T13111 arg1Of associated,also
R8760 T13112 T13113 arg1Of associated,with
R8761 T13114 T13113 arg2Of RA,with
R88 T85 T84 arg1Of control,to
R89 T87 T85 arg2Of signalling,control
R9 T14 T13 arg1Of arthritis,rheumatoid
R90 T87 T86 arg1Of signalling,NF-κB
R91 T92 T88 arg2Of implicated,and
R92 T92 T90 arg2Of implicated,have
R93 T92 T91 arg2Of implicated,been
R9347 T14245 T14244 arg1Of protein,Cylindromatosis
R9348 T14246 T14247 arg1Of Cylindromatosis,(
R9349 T14248 T14247 arg2Of CYLD,(
R9350 T14249 T14247 arg3Of ),(
R9351 T14250 T14246 arg1Of protein,Cylindromatosis
R9352 T14250 T14251 arg1Of protein,was
R9353 T14250 T14253 arg2Of protein,identified
R9354 T14253 T14251 arg2Of identified,was
R9355 T14253 T14252 arg1Of identified,originally
R9356 T14253 T14254 arg1Of identified,as
R9357 T14257 T14254 arg2Of suppressor,as
R9358 T14257 T14255 arg1Of suppressor,a
R9359 T14257 T14256 arg1Of suppressor,tumour
R9360 T14257 T14258 arg2Of suppressor,involved
R9361 T14258 T14259 arg1Of involved,in
R9362 T14261 T14259 arg2Of cylindromatosis,in
R9363 T14261 T14260 arg1Of cylindromatosis,familial
R9364 T14261 T14262 arg1Of cylindromatosis,[
R9365 T14263 T14262 arg2Of 63,[
R9366 T14264 T14262 arg3Of ],[
R9367 T14265 T14266 arg1Of CYLD,is
R9368 T14265 T14268 arg2Of CYLD,involved
R9369 T14268 T14266 arg2Of involved,is
R9370 T14268 T14267 arg1Of involved,also
R9371 T14268 T14269 arg1Of involved,","
R9372 T14268 T14270 arg1Of involved,however
R9373 T14268 T14271 arg1Of involved,","
R9374 T14268 T14272 arg1Of involved,in
R9375 T14275 T14272 arg2Of processes,in
R9376 T14275 T14273 arg1Of processes,diverse
R9377 T14275 T14274 arg1Of processes,physiological
R9378 T14275 T14276 arg1Of processes,ranging
R9379 T14276 T14277 arg1Of ranging,from
R9380 T14276 T14281 arg1Of ranging,to
R9381 T14278 T14279 arg1Of immunity,and
R9382 T14279 T14277 arg2Of and,from
R9383 T14280 T14279 arg2Of inflammation,and
R9384 T14284 T14282 arg1Of progression,cell
R9385 T14284 T14283 arg1Of progression,cycle
R9386 T14284 T14285 arg1Of progression,","
R9387 T14285 T14288 arg1Of ",",and
R9388 T14286 T14285 arg2Of spermatogenesis,","
R9389 T14288 T14281 arg2Of and,to
R9390 T14288 T14287 arg1Of and,","
R9391 T14289 T14288 arg2Of osteoclastogenesis,and
R9392 T14289 T14290 arg1Of osteoclastogenesis,(
R9393 T14291 T14290 arg2Of reviewed,(
R9394 T14291 T14292 arg1Of reviewed,in
R9395 T14291 T14293 arg1Of reviewed,[
R9396 T14294 T14293 arg2Of 64,[
R9397 T14295 T14293 arg3Of ],[
R9398 T14296 T14290 arg3Of ),(
R9399 T14297 T14298 arg1Of CYLD,is
R94 T92 T93 arg1Of implicated,in
R9400 T14298 T14327 arg1Of is,","
R9401 T14298 T14328 arg1Of is,by
R9402 T14301 T14298 arg2Of enzyme,is
R9403 T14301 T14299 arg1Of enzyme,a
R9404 T14301 T14300 arg1Of enzyme,deubiquitinating
R9405 T14301 T14302 arg1Of enzyme,that
R9406 T14301 T14304 arg1Of enzyme,regulates
R9407 T14304 T14303 arg1Of regulates,negatively
R9408 T14306 T14304 arg2Of signalling,regulates
R9409 T14306 T14305 arg1Of signalling,NF-κB
R9410 T14306 T14307 arg2Of signalling,initiated
R9411 T14306 T14316 arg1Of signalling,(
R9412 T14306 T14323 arg1Of signalling,(
R9413 T14309 T14310 arg1Of TNFR,","
R9414 T14310 T14312 arg1Of ",",and
R9415 T14311 T14310 arg2Of RANK,","
R9416 T14312 T14307 arg1Of and,initiated
R9417 T14312 T14308 arg2Of and,by
R9418 T14315 T14312 arg2Of stimulation,and
R9419 T14315 T14313 arg1Of stimulation,T-cell
R9420 T14315 T14314 arg1Of stimulation,receptor
R9421 T14317 T14316 arg2Of reviewed,(
R9422 T14317 T14318 arg1Of reviewed,in
R9423 T14317 T14319 arg1Of reviewed,[
R9424 T14320 T14319 arg2Of 64,[
R9425 T14321 T14319 arg3Of ],[
R9426 T14322 T14316 arg3Of ),(
R9427 T14324 T14323 arg2Of Figure,(
R9428 T14324 T14325 arg1Of Figure,1
R9429 T14326 T14323 arg3Of ),(
R9430 T14333 T14328 arg2Of proteins,by
R9431 T14333 T14329 arg1Of proteins,deubiquitina-ting
R9432 T14333 T14330 arg1Of proteins,several
R9433 T14333 T14331 arg1Of proteins,NF-κB
R9434 T14333 T14332 arg1Of proteins,signalling
R9435 T14333 T14334 arg1Of proteins,including
R9436 T14335 T14336 arg1Of NEMO,","
R9437 T14336 T14338 arg1Of ",",","
R9438 T14337 T14336 arg2Of TRAF2,","
R9439 T14338 T14340 arg1Of ",",","
R9440 T14339 T14338 arg2Of TRAF6,","
R9441 T14340 T14342 arg1Of ",",","
R9442 T14341 T14340 arg2Of TRAF7,","
R9443 T14342 T14344 arg1Of ",",and
R9444 T14343 T14342 arg2Of RIP1,","
R9445 T14344 T14334 arg2Of and,including
R9446 T14345 T14344 arg2Of TAK1,and
R9447 T14346 T14347 arg1Of Many,of
R9448 T14346 T14349 arg1Of Many,are
R9449 T14346 T14351 arg2Of Many,targeted
R9450 T14348 T14347 arg2Of these,of
R9451 T14351 T14349 arg2Of targeted,are
R9452 T14351 T14350 arg1Of targeted,also
R9453 T14351 T14354 arg1Of targeted,and
R9454 T14353 T14351 arg1Of A20,targeted
R9455 T14353 T14352 arg2Of A20,by
R9456 T14356 T14354 arg2Of is,and
R9457 T14356 T14357 arg1Of is,still
R9458 T14356 T14358 arg1Of is,not
R9459 T14359 T14356 arg2Of clear,is
R9460 T14360 T14355 arg1Of why,it
R9461 T14360 T14356 arg1Of why,is
R9462 T14360 T14359 arg1Of why,clear
R9463 T14362 T14361 arg1Of cell,the
R9464 T14362 T14363 arg1Of cell,needs
R9465 T14363 T14360 arg1Of needs,why
R9466 T14363 T14369 modOf needs,to
R9467 T14364 T14367 arg1Of A20,as
R9468 T14367 T14363 arg2Of as,needs
R9469 T14367 T14365 arg1Of as,as
R9470 T14367 T14366 arg1Of as,well
R9471 T14368 T14367 arg2Of CYLD,as
R9472 T14370 T14369 arg1Of control,to
R9473 T14372 T14370 arg2Of activation,control
R9474 T14372 T14371 arg1Of activation,NF-κB
R9475 T14374 T14375 arg1Of A20,is
R9476 T14374 T14377 arg2Of A20,expressed
R9477 T14377 T14373 arg2Of expressed,As
R9478 T14377 T14375 arg2Of expressed,is
R9479 T14377 T14376 arg1Of expressed,only
R9480 T14377 T14378 arg1Of expressed,in
R9481 T14377 T14382 arg1Of expressed,upon
R9482 T14381 T14378 arg2Of types,in
R9483 T14381 T14379 arg1Of types,many
R9484 T14381 T14380 arg1Of types,cell
R9485 T14383 T14382 arg2Of stimulation,upon
R9486 T14385 T14386 arg1Of it,has
R9487 T14385 T14387 arg1Of it,been
R9488 T14385 T14388 arg2Of it,suggested
R9489 T14388 T14373 arg1Of suggested,As
R9490 T14388 T14384 arg1Of suggested,","
R9491 T14388 T14386 arg2Of suggested,has
R9492 T14388 T14387 arg2Of suggested,been
R9493 T14391 T14390 arg1Of protein,this
R9494 T14391 T14393 arg1Of protein,regulates
R9495 T14393 T14392 arg1Of regulates,mainly
R9496 T14393 T14400 arg1Of regulates,whereas
R9497 T14395 T14393 arg2Of phases,regulates
R9498 T14395 T14394 arg1Of phases,later
R9499 T14395 T14396 arg1Of phases,of
R95 T95 T93 arg2Of pathogenesis,in
R9500 T14398 T14396 arg2Of signalling,of
R9501 T14398 T14397 arg1Of signalling,NF-κB
R9502 T14400 T14388 arg3Of whereas,suggested
R9503 T14400 T14389 arg1Of whereas,that
R9504 T14400 T14399 arg1Of whereas,","
R9505 T14401 T14402 arg1Of CYLD,would
R9506 T14401 T14403 arg1Of CYLD,regulate
R9507 T14403 T14400 arg2Of regulate,whereas
R9508 T14403 T14402 arg2Of regulate,would
R9509 T14404 T14405 arg1Of constitutive,and
R9510 T14406 T14405 arg2Of early,and
R9511 T14407 T14403 arg2Of signalling,regulate
R9512 T14407 T14404 arg1Of signalling,constitutive
R9513 T14407 T14406 arg1Of signalling,early
R9514 T14409 T14408 arg2Of addition,In
R9515 T14413 T14411 arg1Of activity,their
R9516 T14413 T14412 arg1Of activity,relative
R9517 T14413 T14414 arg1Of activity,might
R9518 T14413 T14416 arg1Of activity,be
R9519 T14413 T14418 arg1Of activity,dependent
R9520 T14416 T14408 arg1Of be,In
R9521 T14416 T14410 arg1Of be,","
R9522 T14416 T14414 arg2Of be,might
R9523 T14416 T14415 arg1Of be,also
R9524 T14416 T14419 arg1Of be,[
R9525 T14418 T14416 arg2Of dependent,be
R9526 T14418 T14417 arg1Of dependent,cell-type
R9527 T14420 T14419 arg2Of 64,[
R9528 T14421 T14419 arg3Of ],[
R9529 T14424 T14425 arg1Of CYLD,has
R9530 T14424 T14426 arg1Of CYLD,been
R9531 T14424 T14427 arg2Of CYLD,shown
R9532 T14424 T14430 arg1Of CYLD,regulate
R9533 T14427 T14422 arg1Of shown,Interestingly
R9534 T14427 T14423 arg1Of shown,","
R9535 T14427 T14425 arg2Of shown,has
R9536 T14427 T14426 arg2Of shown,been
R9537 T14430 T14427 arg3Of regulate,shown
R9538 T14430 T14428 arg1Of regulate,to
R9539 T14430 T14429 arg1Of regulate,negatively
R9540 T14432 T14431 arg1Of signalling,RANK
R9541 T14432 T14433 arg1Of signalling,and
R9542 T14433 T14430 arg2Of and,regulate
R9543 T14433 T14435 arg1Of and,in
R9544 T14434 T14433 arg2Of osteoclastogenesis,and
R9545 T14436 T14435 arg2Of mice,in
R9546 T14436 T14437 arg1Of mice,[
R9547 T14438 T14437 arg2Of 65,[
R9548 T14439 T14437 arg3Of ],[
R9549 T14440 T14441 arg1Of Mice,with
R9550 T14440 T14447 arg1Of Mice,have
R9551 T14440 T14452 arg1Of Mice,develop
R9552 T14444 T14441 arg2Of deficiency,with
R9553 T14444 T14442 arg1Of deficiency,a
R9554 T14444 T14443 arg1Of deficiency,genetic
R9555 T14444 T14445 arg1Of deficiency,of
R9556 T14446 T14445 arg2Of CYLD,of
R9557 T14447 T14451 arg1Of have,and
R9558 T14450 T14447 arg2Of differentiation,have
R9559 T14450 T14448 arg1Of differentiation,aberrant
R9560 T14450 T14449 arg1Of differentiation,osteoclast
R9561 T14452 T14451 arg2Of develop,and
R9562 T14454 T14452 arg2Of osteoporosis,develop
R9563 T14454 T14453 arg1Of osteoporosis,severe
R9564 T14456 T14455 arg1Of precursors,Osteoclast
R9565 T14456 T14457 arg1Of precursors,of
R9566 T14456 T14460 arg1Of precursors,are
R9567 T14456 T14461 arg1Of precursors,hyper-responsive
R9568 T14456 T14466 arg1Of precursors,produce
R9569 T14459 T14457 arg2Of mice,of
R9570 T14459 T14458 arg1Of mice,these
R9571 T14460 T14465 arg1Of are,and
R9572 T14461 T14460 arg2Of hyper-responsive,are
R9573 T14461 T14462 arg1Of hyper-responsive,to
R9574 T14464 T14462 arg2Of differentiation,to
R9575 T14464 T14463 arg1Of differentiation,RANKL-induced
R9576 T14466 T14465 arg2Of produce,and
R9577 T14467 T14468 arg1Of more,and
R9578 T14469 T14468 arg2Of larger,and
R9579 T14470 T14466 arg2Of osteoclasts,produce
R9580 T14470 T14467 arg1Of osteoclasts,more
R9581 T14470 T14469 arg1Of osteoclasts,larger
R9582 T14472 T14471 arg1Of expression,CYLD
R9583 T14472 T14473 arg1Of expression,is
R9584 T14472 T14475 arg2Of expression,upregulated
R9585 T14472 T14482 arg1Of expression,is
R9586 T14472 T14483 arg2Of expression,recruited
R9587 T14475 T14473 arg2Of upregulated,is
R9588 T14475 T14474 arg1Of upregulated,markedly
R9589 T14475 T14476 arg1Of upregulated,under
R9590 T14475 T14481 arg1Of upregulated,and
R9591 T14477 T14476 arg2Of conditions,under
R9592 T14477 T14478 arg1Of conditions,of
R9593 T14480 T14478 arg2Of osteoclastogenesis,of
R9594 T14480 T14479 arg1Of osteoclastogenesis,RANKL-induced
R9595 T14481 T14503 arg1Of and,","
R9596 T14481 T14504 modOf and,followed
R9597 T14483 T14481 arg2Of recruited,and
R9598 T14483 T14482 arg2Of recruited,is
R9599 T14483 T14484 arg1Of recruited,to
R96 T95 T94 arg1Of pathogenesis,the
R9600 T14483 T14487 arg1Of recruited,via
R9601 T14483 T14500 arg1Of recruited,[
R9602 T14486 T14484 arg2Of TRAF6,to
R9603 T14486 T14485 arg2Of TRAF6,ubiquitinated
R9604 T14492 T14487 arg2Of p62,via
R9605 T14492 T14488 arg1Of p62,the
R9606 T14492 T14489 arg1Of p62,ubiquitin-binding
R9607 T14492 T14490 arg1Of p62,adaptor
R9608 T14492 T14491 arg1Of p62,protein
R9609 T14492 T14493 arg1Of p62,(
R9610 T14495 T14493 arg2Of known,(
R9611 T14495 T14494 arg1Of known,also
R9612 T14495 T14496 arg1Of known,as
R9613 T14497 T14496 arg2Of sequestosome,as
R9614 T14497 T14498 arg1Of sequestosome,1
R9615 T14499 T14493 arg3Of ),(
R9616 T14501 T14500 arg2Of 65,[
R9617 T14502 T14500 arg3Of ],[
R9618 T14508 T14504 arg1Of deubiquitination,followed
R9619 T14508 T14505 arg2Of deubiquitination,by
R9620 T14508 T14506 arg1Of deubiquitination,the
R9621 T14508 T14507 arg1Of deubiquitination,CYLD-mediated
R9622 T14508 T14509 arg1Of deubiquitination,of
R9623 T14510 T14509 arg2Of TRAF6,of
R9624 T14513 T14511 arg2Of context,In
R9625 T14513 T14512 arg1Of context,this
R9626 T14515 T14516 arg1Of it,is
R9627 T14515 T14517 arg1Of it,worth
R9628 T14516 T14511 arg1Of is,In
R9629 T14516 T14514 arg1Of is,","
R9630 T14517 T14516 arg2Of worth,is
R9631 T14518 T14517 arg2Of mentioning,worth
R9632 T14521 T14520 arg1Of mice,transgenic
R9633 T14521 T14522 arg1Of mice,expressing
R9634 T14521 T14529 arg1Of mice,display
R9635 T14521 T14533 arg1Of mice,develop
R9636 T14525 T14522 arg2Of form,expressing
R9637 T14525 T14523 arg1Of form,a
R9638 T14525 T14524 arg2Of form,mutated
R9639 T14525 T14526 arg1Of form,of
R9640 T14527 T14526 arg2Of p62,of
R9641 T14529 T14532 arg1Of display,and
R9642 T14531 T14529 arg2Of osteoclastogenesis,display
R9643 T14531 T14530 arg1Of osteoclastogenesis,abnormal
R9644 T14532 T14518 arg2Of and,mentioning
R9645 T14532 T14519 arg1Of and,that
R9646 T14532 T14528 arg1Of and,also
R9647 T14533 T14532 arg2Of develop,and
R9648 T14533 T14537 arg1Of develop,[
R9649 T14536 T14533 arg2Of loss,develop
R9650 T14536 T14534 arg1Of loss,progressive
R9651 T14536 T14535 arg1Of loss,bone
R9652 T14538 T14537 arg2Of 66,[
R9653 T14539 T14537 arg3Of ],[
R9654 T14541 T14540 arg1Of findings,These
R9655 T14541 T14542 arg1Of findings,suggest
R9656 T14545 T14544 arg1Of inhibi-tion,CYLD-mediated
R9657 T14545 T14546 arg1Of inhibi-tion,of
R9658 T14545 T14550 arg1Of inhibi-tion,plays
R9659 T14545 T14561 arg1Of inhibi-tion,indicate
R9660 T14549 T14546 arg2Of signalling,of
R9661 T14549 T14547 arg1Of signalling,RANK-induced
R9662 T14549 T14548 arg1Of signalling,NF-κB
R9663 T14550 T14554 arg1Of plays,in
R9664 T14550 T14560 arg1Of plays,and
R9665 T14553 T14550 arg2Of role,plays
R9666 T14553 T14551 arg1Of role,a
R9667 T14553 T14552 arg1Of role,key
R9668 T14557 T14554 arg2Of regulation,in
R9669 T14557 T14555 arg1Of regulation,the
R9670 T14557 T14556 arg1Of regulation,negative
R9671 T14557 T14558 arg1Of regulation,of
R9672 T14559 T14558 arg2Of osteoclastogenesis,of
R9673 T14560 T14542 arg2Of and,suggest
R9674 T14560 T14543 arg1Of and,that
R9675 T14561 T14560 arg2Of indicate,and
R9676 T14561 T14563 arg1Of indicate,as
R9677 T14562 T14561 arg2Of CYLD,indicate
R9678 T14567 T14563 arg2Of factor,as
R9679 T14567 T14564 arg1Of factor,a
R9680 T14567 T14565 arg1Of factor,potential
R9681 T14567 T14566 arg1Of factor,genetic
R9682 T14567 T14568 arg2Of factor,involved
R9683 T14568 T14569 arg1Of involved,in
R9684 T14571 T14569 arg2Of pathology,in
R9685 T14571 T14570 arg1Of pathology,the
R9686 T14571 T14572 arg1Of pathology,of
R9687 T14574 T14572 arg2Of disorders,of
R9688 T14574 T14573 arg1Of disorders,bone
R9689 T14574 T14576 arg1Of disorders,as
R9690 T14576 T14575 arg1Of as,such
R9691 T14577 T14576 arg2Of RA,as
R97 T95 T96 arg1Of pathogenesis,of
R98 T98 T96 arg2Of arthritis,of
R99 T98 T97 arg1Of arthritis,rheumatoid