Id |
Subject |
Object |
Predicate |
Lexical cue |
T469 |
0-9 |
NN |
denotes |
OBJECTIVE |
T470 |
10-13 |
DT |
denotes |
The |
T471 |
14-23 |
NN |
denotes |
objective |
T472 |
24-26 |
IN |
denotes |
of |
T473 |
27-31 |
DT |
denotes |
this |
T2791 |
27-31 |
DT |
denotes |
this |
T474 |
32-37 |
NN |
denotes |
study |
T2792 |
32-37 |
NN |
denotes |
study |
T475 |
38-41 |
VB |
denotes |
was |
T2793 |
38-41 |
VB |
denotes |
was |
T476 |
42-44 |
TO |
denotes |
to |
T477 |
45-54 |
VB |
denotes |
determine |
T478 |
55-58 |
DT |
denotes |
the |
T479 |
59-65 |
NN |
denotes |
effect |
T480 |
66-68 |
IN |
denotes |
of |
T481 |
69-80 |
JJ |
denotes |
nonspecific |
T482 |
81-98 |
NN |
denotes |
phosphodiesterase |
T483 |
99-109 |
NN |
denotes |
inhibition |
T484 |
110-112 |
IN |
denotes |
on |
T485 |
113-126 |
NN |
denotes |
transcription |
T486 |
127-133 |
NN |
denotes |
factor |
T487 |
134-144 |
NN |
denotes |
activation |
T488 |
145-148 |
CC |
denotes |
and |
T489 |
149-154 |
NN |
denotes |
tumor |
T490 |
155-163 |
NN |
denotes |
necrosis |
T491 |
164-176 |
NN |
denotes |
factor-alpha |
T492 |
177-178 |
-LRB- |
denotes |
( |
T493 |
178-183 |
NN |
denotes |
TNF-α |
T494 |
183-184 |
-RRB- |
denotes |
) |
T495 |
185-195 |
NN |
denotes |
production |
T496 |
196-198 |
IN |
denotes |
in |
T497 |
199-217 |
NN |
denotes |
lipopolysaccharide |
T498 |
218-219 |
-LRB- |
denotes |
( |
T499 |
219-222 |
NN |
denotes |
LPS |
T500 |
222-223 |
-RRB- |
denotes |
) |
T501 |
223-234 |
JJ |
denotes |
-stimulated |
T502 |
235-240 |
JJ |
denotes |
human |
T503 |
241-252 |
JJ |
denotes |
mononuclear |
T504 |
253-258 |
NN |
denotes |
cells |
T505 |
261-273 |
NN |
denotes |
INTRODUCTION |
T506 |
274-277 |
DT |
denotes |
The |
T507 |
278-288 |
NN |
denotes |
production |
T508 |
289-291 |
IN |
denotes |
of |
T509 |
292-297 |
NN |
denotes |
TNF-α |
T510 |
298-307 |
VB |
denotes |
following |
T511 |
308-311 |
NN |
denotes |
LPS |
T512 |
312-323 |
NN |
denotes |
stimulation |
T513 |
324-326 |
VB |
denotes |
is |
T514 |
327-330 |
CD |
denotes |
one |
T515 |
331-333 |
IN |
denotes |
of |
T516 |
334-337 |
DT |
denotes |
the |
T517 |
338-341 |
JJ |
denotes |
key |
T518 |
342-347 |
NN |
denotes |
steps |
T519 |
348-350 |
IN |
denotes |
in |
T520 |
351-360 |
JJ |
denotes |
bacterial |
T521 |
361-367 |
NN |
denotes |
sepsis |
T522 |
368-371 |
CC |
denotes |
and |
T523 |
372-384 |
NN |
denotes |
inflammation |
T524 |
386-389 |
DT |
denotes |
The |
T525 |
390-399 |
NN |
denotes |
mechanism |
T526 |
400-402 |
IN |
denotes |
by |
T527 |
403-408 |
WDT |
denotes |
which |
T528 |
409-426 |
NN |
denotes |
phosphodiesterase |
T529 |
427-437 |
NN |
denotes |
inhibition |
T530 |
438-444 |
VB |
denotes |
alters |
T531 |
445-450 |
NN |
denotes |
TNF-α |
T532 |
451-461 |
NN |
denotes |
production |
T533 |
462-464 |
IN |
denotes |
in |
T534 |
465-468 |
DT |
denotes |
the |
T535 |
469-477 |
NN |
denotes |
presence |
T536 |
478-480 |
IN |
denotes |
of |
T537 |
481-484 |
NN |
denotes |
LPS |
T538 |
485-492 |
VB |
denotes |
remains |
T539 |
493-500 |
JJ |
denotes |
unclear |
T540 |
503-510 |
NN |
denotes |
METHODS |
T541 |
511-516 |
JJ |
denotes |
Human |
T542 |
517-528 |
JJ |
denotes |
mononuclear |
T543 |
529-534 |
NN |
denotes |
cells |
T544 |
535-539 |
VB |
denotes |
were |
T545 |
540-550 |
VB |
denotes |
stimulated |
T546 |
551-555 |
IN |
denotes |
with |
T547 |
556-559 |
NN |
denotes |
LPS |
T548 |
560-561 |
-LRB- |
denotes |
( |
T549 |
561-562 |
CD |
denotes |
1 |
T550 |
563-568 |
NN |
denotes |
μg/mL |
T551 |
568-569 |
-RRB- |
denotes |
) |
T552 |
569-570 |
-COMMA- |
denotes |
, |
T553 |
571-573 |
IN |
denotes |
in |
T554 |
574-577 |
DT |
denotes |
the |
T555 |
578-586 |
NN |
denotes |
presence |
T556 |
587-590 |
CC |
denotes |
and |
T557 |
591-598 |
NN |
denotes |
absence |
T558 |
599-601 |
IN |
denotes |
of |
T559 |
602-616 |
NN |
denotes |
Pentoxifylline |
T560 |
617-618 |
-LRB- |
denotes |
( |
T561 |
618-621 |
NN |
denotes |
PTX |
T562 |
621-622 |
-COLON- |
denotes |
; |
T563 |
623-625 |
CD |
denotes |
20 |
T564 |
626-628 |
NN |
denotes |
mM |
T565 |
628-629 |
-RRB- |
denotes |
) |
T566 |
629-630 |
-COMMA- |
denotes |
, |
T567 |
631-632 |
DT |
denotes |
a |
T568 |
633-644 |
JJ |
denotes |
nonspecific |
T569 |
645-662 |
NN |
denotes |
phosphodiesterase |
T570 |
663-672 |
NN |
denotes |
inhibitor |
T571 |
674-681 |
JJ |
denotes |
Western |
T572 |
682-690 |
NN |
denotes |
blotting |
T573 |
691-693 |
IN |
denotes |
of |
T574 |
694-708 |
VB |
denotes |
phosphorylated |
T575 |
709-720 |
JJ |
denotes |
cytoplasmic |
T576 |
721-726 |
NN |
denotes |
I-κBα |
T577 |
726-727 |
-COMMA- |
denotes |
, |
T578 |
728-735 |
JJ |
denotes |
nuclear |
T579 |
736-745 |
NN |
denotes |
factor-κB |
T580 |
746-749 |
NN |
denotes |
p65 |
T581 |
750-751 |
-LRB- |
denotes |
( |
T582 |
751-756 |
NN |
denotes |
NF-κB |
T583 |
756-757 |
-RRB- |
denotes |
) |
T584 |
757-758 |
-COMMA- |
denotes |
, |
T585 |
759-762 |
CC |
denotes |
and |
T586 |
763-770 |
JJ |
denotes |
nuclear |
T587 |
771-784 |
JJ |
denotes |
cAMP-response |
T588 |
785-792 |
NN |
denotes |
element |
T589 |
793-800 |
NN |
denotes |
binding |
T590 |
801-808 |
NN |
denotes |
protein |
T591 |
809-810 |
-LRB- |
denotes |
( |
T592 |
810-814 |
NN |
denotes |
CREB |
T593 |
814-815 |
-RRB- |
denotes |
) |
T594 |
816-819 |
VB |
denotes |
was |
T595 |
820-829 |
VB |
denotes |
performed |
T596 |
831-834 |
NN |
denotes |
DNA |
T597 |
835-842 |
NN |
denotes |
binding |
T598 |
843-845 |
IN |
denotes |
of |
T599 |
846-851 |
NN |
denotes |
NF-κB |
T600 |
852-855 |
CC |
denotes |
and |
T601 |
856-860 |
NN |
denotes |
CREB |
T602 |
861-864 |
VB |
denotes |
was |
T603 |
865-873 |
VB |
denotes |
verified |
T604 |
874-876 |
IN |
denotes |
by |
T605 |
877-892 |
JJ |
denotes |
electrophoretic |
T606 |
893-901 |
NN |
denotes |
mobility |
T607 |
902-907 |
NN |
denotes |
shift |
T608 |
908-913 |
NN |
denotes |
assay |
T609 |
915-920 |
NN |
denotes |
TNF-α |
T610 |
921-927 |
NN |
denotes |
levels |
T611 |
928-932 |
VB |
denotes |
were |
T612 |
933-943 |
VB |
denotes |
determined |
T613 |
944-946 |
IN |
denotes |
in |
T614 |
947-950 |
DT |
denotes |
the |
T615 |
951-962 |
NN |
denotes |
supernatant |
T616 |
963-965 |
IN |
denotes |
of |
T617 |
966-976 |
VB |
denotes |
stimulated |
T618 |
977-982 |
NN |
denotes |
cells |
T619 |
983-985 |
IN |
denotes |
in |
T620 |
986-989 |
DT |
denotes |
the |
T621 |
990-998 |
NN |
denotes |
presence |
T622 |
999-1002 |
CC |
denotes |
and |
T623 |
1003-1010 |
NN |
denotes |
absence |
T624 |
1011-1018 |
NN |
denotes |
Protein |
T625 |
1019-1025 |
NN |
denotes |
kinase |
T626 |
1026-1027 |
NN |
denotes |
A |
T627 |
1028-1038 |
NN |
denotes |
inhibition |
T628 |
1039-1041 |
IN |
denotes |
by |
T629 |
1042-1044 |
DT |
denotes |
an |
T630 |
1045-1058 |
JJ |
denotes |
enzyme-linked |
T631 |
1059-1072 |
JJ |
denotes |
immunosorbent |
T632 |
1073-1078 |
NN |
denotes |
assay |
T633 |
1079-1080 |
-LRB- |
denotes |
( |
T634 |
1080-1085 |
NN |
denotes |
ELISA |
T635 |
1085-1086 |
-RRB- |
denotes |
) |
T636 |
1089-1096 |
NN |
denotes |
RESULTS |
T637 |
1097-1100 |
NN |
denotes |
PTX |
T638 |
1101-1104 |
VB |
denotes |
was |
T639 |
1105-1117 |
VB |
denotes |
demonstrated |
T640 |
1118-1120 |
TO |
denotes |
to |
T641 |
1121-1134 |
RB |
denotes |
significantly |
T642 |
1135-1141 |
VB |
denotes |
reduce |
T643 |
1142-1153 |
JJ |
denotes |
cytoplasmic |
T644 |
1154-1159 |
NN |
denotes |
I-κBα |
T645 |
1160-1175 |
NN |
denotes |
phosphorylation |
T646 |
1175-1176 |
-COMMA- |
denotes |
, |
T647 |
1177-1184 |
JJ |
denotes |
nuclear |
T648 |
1185-1188 |
NN |
denotes |
p65 |
T649 |
1189-1204 |
NN |
denotes |
phosphorylation |
T650 |
1204-1205 |
-COMMA- |
denotes |
, |
T651 |
1206-1209 |
CC |
denotes |
and |
T652 |
1210-1213 |
DT |
denotes |
the |
T653 |
1214-1217 |
NN |
denotes |
DNA |
T654 |
1218-1225 |
NN |
denotes |
binding |
T655 |
1226-1234 |
NN |
denotes |
activity |
T656 |
1235-1237 |
IN |
denotes |
of |
T657 |
1238-1243 |
NN |
denotes |
NF-κB |
T658 |
1245-1247 |
IN |
denotes |
In |
T659 |
1248-1256 |
NN |
denotes |
contrast |
T660 |
1256-1257 |
-COMMA- |
denotes |
, |
T661 |
1258-1261 |
NN |
denotes |
PTX |
T662 |
1262-1270 |
RB |
denotes |
markedly |
T663 |
1271-1279 |
VB |
denotes |
enhanced |
T664 |
1280-1283 |
DT |
denotes |
the |
T665 |
1284-1299 |
NN |
denotes |
phosphorylation |
T666 |
1300-1303 |
CC |
denotes |
and |
T667 |
1304-1307 |
NN |
denotes |
DNA |
T668 |
1308-1315 |
NN |
denotes |
binding |
T669 |
1316-1324 |
NN |
denotes |
activity |
T670 |
1325-1327 |
IN |
denotes |
of |
T671 |
1328-1332 |
NN |
denotes |
CREB |
T672 |
1334-1339 |
NN |
denotes |
Cells |
T673 |
1340-1353 |
RB |
denotes |
concomitantly |
T674 |
1354-1361 |
VB |
denotes |
treated |
T675 |
1362-1366 |
IN |
denotes |
with |
T676 |
1367-1370 |
NN |
denotes |
PTX |
T677 |
1371-1374 |
CC |
denotes |
and |
T678 |
1375-1378 |
NN |
denotes |
LPS |
T679 |
1379-1387 |
VB |
denotes |
secreted |
T680 |
1388-1395 |
JJ |
denotes |
similar |
T681 |
1396-1402 |
NN |
denotes |
levels |
T682 |
1403-1405 |
IN |
denotes |
of |
T683 |
1406-1411 |
NN |
denotes |
TNF-α |
T684 |
1412-1414 |
IN |
denotes |
in |
T685 |
1415-1418 |
DT |
denotes |
the |
T686 |
1419-1427 |
NN |
denotes |
presence |
T687 |
1428-1431 |
CC |
denotes |
and |
T688 |
1432-1439 |
NN |
denotes |
absence |
T689 |
1440-1447 |
NN |
denotes |
Protein |
T690 |
1448-1454 |
NN |
denotes |
kinase |
T691 |
1455-1456 |
NN |
denotes |
A |
T692 |
1457-1467 |
NN |
denotes |
inhibition |
T693 |
1470-1480 |
NN |
denotes |
DISCUSSION |
T694 |
1481-1484 |
DT |
denotes |
The |
T695 |
1485-1494 |
VB |
denotes |
increased |
T696 |
1495-1500 |
NN |
denotes |
level |
T697 |
1501-1503 |
IN |
denotes |
of |
T698 |
1504-1508 |
NN |
denotes |
cAMP |
T699 |
1509-1513 |
WDT |
denotes |
that |
T700 |
1514-1521 |
VB |
denotes |
results |
T701 |
1522-1526 |
IN |
denotes |
from |
T702 |
1527-1544 |
NN |
denotes |
phosphodiesterase |
T703 |
1545-1555 |
NN |
denotes |
inhibition |
T704 |
1556-1563 |
VB |
denotes |
affects |
T705 |
1564-1575 |
JJ |
denotes |
cytoplasmic |
T706 |
1576-1579 |
CC |
denotes |
and |
T707 |
1580-1587 |
JJ |
denotes |
nuclear |
T708 |
1588-1594 |
NN |
denotes |
events |
T709 |
1594-1595 |
-COMMA- |
denotes |
, |
T710 |
1596-1605 |
VB |
denotes |
resulting |
T711 |
1606-1608 |
IN |
denotes |
in |
T712 |
1609-1612 |
DT |
denotes |
the |
T713 |
1613-1624 |
NN |
denotes |
attenuation |
T714 |
1625-1627 |
IN |
denotes |
of |
T715 |
1628-1633 |
NN |
denotes |
NF-κB |
T716 |
1634-1637 |
CC |
denotes |
and |
T717 |
1638-1641 |
DT |
denotes |
the |
T718 |
1642-1652 |
NN |
denotes |
activation |
T719 |
1653-1655 |
IN |
denotes |
of |
T720 |
1656-1660 |
NN |
denotes |
CREB |
T721 |
1661-1676 |
JJ |
denotes |
transcriptional |
T722 |
1677-1680 |
NN |
denotes |
DNA |
T723 |
1681-1688 |
NN |
denotes |
binding |
T724 |
1689-1696 |
IN |
denotes |
through |
T725 |
1697-1705 |
NN |
denotes |
pathways |
T726 |
1706-1710 |
WDT |
denotes |
that |
T727 |
1711-1714 |
VB |
denotes |
are |
T728 |
1715-1724 |
RB |
denotes |
partially |
T729 |
1725-1732 |
NN |
denotes |
Protein |
T730 |
1733-1739 |
NN |
denotes |
kinase |
T731 |
1740-1753 |
JJ |
denotes |
A-independent |
T732 |
1756-1766 |
NN |
denotes |
CONCLUSION |
T733 |
1767-1779 |
JJ |
denotes |
PTX-mediated |
T734 |
1780-1797 |
NN |
denotes |
phosphodiesterase |
T735 |
1798-1808 |
NN |
denotes |
inhibition |
T736 |
1809-1815 |
VB |
denotes |
occurs |
T737 |
1816-1825 |
RB |
denotes |
partially |
T738 |
1826-1833 |
IN |
denotes |
through |
T739 |
1834-1835 |
DT |
denotes |
a |
T740 |
1836-1843 |
NN |
denotes |
Protein |
T741 |
1844-1850 |
NN |
denotes |
kinase |
T742 |
1851-1864 |
JJ |
denotes |
A-independent |
T743 |
1865-1872 |
NN |
denotes |
pathway |
T744 |
1873-1876 |
CC |
denotes |
and |
T745 |
1877-1880 |
MD |
denotes |
may |
T746 |
1881-1886 |
VB |
denotes |
serve |
T747 |
1887-1889 |
IN |
denotes |
as |
T748 |
1890-1891 |
DT |
denotes |
a |
T749 |
1892-1898 |
JJ |
denotes |
useful |
T750 |
1899-1903 |
NN |
denotes |
tool |
T751 |
1904-1906 |
IN |
denotes |
in |
T752 |
1907-1910 |
DT |
denotes |
the |
T753 |
1911-1922 |
NN |
denotes |
attenuation |
T754 |
1923-1925 |
IN |
denotes |
of |
T755 |
1926-1937 |
JJ |
denotes |
LPS-induced |
T756 |
1938-1950 |
NN |
denotes |
inflammation |
R2218 |
T2792 |
T2791 |
arg1Of |
study,this |
R2219 |
T2792 |
T2793 |
arg1Of |
study,was |
R365 |
T471 |
T470 |
arg1Of |
objective,The |
R366 |
T471 |
T472 |
arg1Of |
objective,of |
R367 |
T471 |
T475 |
arg1Of |
objective,was |
R368 |
T474 |
T472 |
arg2Of |
study,of |
R369 |
T474 |
T473 |
arg1Of |
study,this |
R370 |
T477 |
T475 |
arg2Of |
determine,was |
R371 |
T477 |
T476 |
arg1Of |
determine,to |
R372 |
T479 |
T477 |
arg2Of |
effect,determine |
R373 |
T479 |
T478 |
arg1Of |
effect,the |
R374 |
T479 |
T480 |
arg1Of |
effect,of |
R375 |
T479 |
T484 |
arg1Of |
effect,on |
R376 |
T483 |
T480 |
arg2Of |
inhibition,of |
R377 |
T483 |
T481 |
arg1Of |
inhibition,nonspecific |
R378 |
T483 |
T482 |
arg1Of |
inhibition,phosphodiesterase |
R379 |
T487 |
T485 |
arg1Of |
activation,transcription |
R380 |
T487 |
T486 |
arg1Of |
activation,factor |
R381 |
T487 |
T488 |
arg1Of |
activation,and |
R382 |
T488 |
T484 |
arg2Of |
and,on |
R383 |
T488 |
T496 |
arg1Of |
and,in |
R384 |
T491 |
T489 |
arg1Of |
factor-alpha,tumor |
R385 |
T491 |
T490 |
arg1Of |
factor-alpha,necrosis |
R386 |
T491 |
T492 |
arg1Of |
factor-alpha,( |
R387 |
T493 |
T492 |
arg2Of |
TNF-α,( |
R388 |
T494 |
T492 |
arg3Of |
),( |
R389 |
T495 |
T488 |
arg2Of |
production,and |
R390 |
T495 |
T491 |
arg1Of |
production,factor-alpha |
R391 |
T499 |
T498 |
arg2Of |
LPS,( |
R392 |
T500 |
T498 |
arg3Of |
),( |
R393 |
T501 |
T497 |
arg1Of |
-stimulated,lipopolysaccharide |
R394 |
T501 |
T498 |
arg1Of |
-stimulated,( |
R395 |
T504 |
T496 |
arg2Of |
cells,in |
R396 |
T504 |
T501 |
arg1Of |
cells,-stimulated |
R397 |
T504 |
T502 |
arg1Of |
cells,human |
R398 |
T504 |
T503 |
arg1Of |
cells,mononuclear |
R399 |
T507 |
T506 |
arg1Of |
production,The |
R400 |
T507 |
T508 |
arg1Of |
production,of |
R401 |
T507 |
T510 |
arg1Of |
production,following |
R402 |
T507 |
T513 |
arg1Of |
production,is |
R403 |
T509 |
T508 |
arg2Of |
TNF-α,of |
R404 |
T512 |
T510 |
arg2Of |
stimulation,following |
R405 |
T512 |
T511 |
arg1Of |
stimulation,LPS |
R406 |
T514 |
T513 |
arg2Of |
one,is |
R407 |
T514 |
T515 |
arg1Of |
one,of |
R408 |
T518 |
T515 |
arg2Of |
steps,of |
R409 |
T518 |
T516 |
arg1Of |
steps,the |
R410 |
T518 |
T517 |
arg1Of |
steps,key |
R411 |
T518 |
T519 |
arg1Of |
steps,in |
R412 |
T521 |
T522 |
arg1Of |
sepsis,and |
R413 |
T522 |
T519 |
arg2Of |
and,in |
R414 |
T522 |
T520 |
arg1Of |
and,bacterial |
R415 |
T523 |
T522 |
arg2Of |
inflammation,and |
R416 |
T525 |
T524 |
arg1Of |
mechanism,The |
R417 |
T525 |
T526 |
arg2Of |
mechanism,by |
R418 |
T525 |
T527 |
arg1Of |
mechanism,which |
R419 |
T525 |
T538 |
arg1Of |
mechanism,remains |
R420 |
T525 |
T539 |
arg1Of |
mechanism,unclear |
R421 |
T529 |
T528 |
arg1Of |
inhibition,phosphodiesterase |
R422 |
T529 |
T530 |
arg1Of |
inhibition,alters |
R423 |
T530 |
T526 |
arg1Of |
alters,by |
R424 |
T530 |
T533 |
arg1Of |
alters,in |
R425 |
T532 |
T530 |
arg2Of |
production,alters |
R426 |
T532 |
T531 |
arg1Of |
production,TNF-α |
R427 |
T535 |
T533 |
arg2Of |
presence,in |
R428 |
T535 |
T534 |
arg1Of |
presence,the |
R429 |
T535 |
T536 |
arg1Of |
presence,of |
R430 |
T537 |
T536 |
arg2Of |
LPS,of |
R431 |
T539 |
T538 |
arg2Of |
unclear,remains |
R432 |
T543 |
T541 |
arg1Of |
cells,Human |
R433 |
T543 |
T542 |
arg1Of |
cells,mononuclear |
R434 |
T543 |
T544 |
arg1Of |
cells,were |
R435 |
T543 |
T545 |
arg2Of |
cells,stimulated |
R436 |
T545 |
T544 |
arg2Of |
stimulated,were |
R437 |
T545 |
T546 |
arg1Of |
stimulated,with |
R438 |
T547 |
T546 |
arg2Of |
LPS,with |
R439 |
T547 |
T548 |
arg1Of |
LPS,( |
R440 |
T547 |
T552 |
arg1Of |
LPS,"," |
R441 |
T547 |
T553 |
arg1Of |
LPS,in |
R442 |
T547 |
T566 |
arg1Of |
LPS,"," |
R443 |
T550 |
T548 |
arg2Of |
μg/mL,( |
R444 |
T550 |
T549 |
arg1Of |
μg/mL,1 |
R445 |
T551 |
T548 |
arg3Of |
),( |
R446 |
T555 |
T556 |
arg1Of |
presence,and |
R447 |
T556 |
T553 |
arg2Of |
and,in |
R448 |
T556 |
T554 |
arg1Of |
and,the |
R449 |
T556 |
T558 |
arg1Of |
and,of |
R450 |
T557 |
T556 |
arg2Of |
absence,and |
R451 |
T559 |
T558 |
arg2Of |
Pentoxifylline,of |
R452 |
T559 |
T560 |
arg1Of |
Pentoxifylline,( |
R453 |
T561 |
T562 |
arg1Of |
PTX,; |
R454 |
T562 |
T560 |
arg2Of |
;,( |
R455 |
T564 |
T562 |
arg2Of |
mM,; |
R456 |
T564 |
T563 |
arg1Of |
mM,20 |
R457 |
T565 |
T560 |
arg3Of |
),( |
R458 |
T570 |
T566 |
arg2Of |
inhibitor,"," |
R459 |
T570 |
T567 |
arg1Of |
inhibitor,a |
R460 |
T570 |
T568 |
arg1Of |
inhibitor,nonspecific |
R461 |
T570 |
T569 |
arg1Of |
inhibitor,phosphodiesterase |
R462 |
T572 |
T571 |
arg1Of |
blotting,Western |
R463 |
T572 |
T573 |
arg1Of |
blotting,of |
R464 |
T572 |
T594 |
arg1Of |
blotting,was |
R465 |
T572 |
T595 |
arg2Of |
blotting,performed |
R466 |
T576 |
T574 |
arg2Of |
I-κBα,phosphorylated |
R467 |
T576 |
T575 |
arg1Of |
I-κBα,cytoplasmic |
R468 |
T576 |
T577 |
arg1Of |
I-κBα,"," |
R469 |
T577 |
T585 |
arg1Of |
",",and |
R470 |
T580 |
T577 |
arg2Of |
p65,"," |
R471 |
T580 |
T578 |
arg1Of |
p65,nuclear |
R472 |
T580 |
T579 |
arg1Of |
p65,factor-κB |
R473 |
T580 |
T581 |
arg1Of |
p65,( |
R474 |
T582 |
T581 |
arg2Of |
NF-κB,( |
R475 |
T583 |
T581 |
arg3Of |
),( |
R476 |
T585 |
T573 |
arg2Of |
and,of |
R477 |
T585 |
T584 |
arg1Of |
and,"," |
R478 |
T590 |
T585 |
arg2Of |
protein,and |
R479 |
T590 |
T586 |
arg1Of |
protein,nuclear |
R480 |
T590 |
T587 |
arg1Of |
protein,cAMP-response |
R481 |
T590 |
T588 |
arg1Of |
protein,element |
R482 |
T590 |
T589 |
arg1Of |
protein,binding |
R483 |
T590 |
T591 |
arg1Of |
protein,( |
R484 |
T592 |
T591 |
arg2Of |
CREB,( |
R485 |
T593 |
T591 |
arg3Of |
),( |
R486 |
T595 |
T594 |
arg2Of |
performed,was |
R487 |
T597 |
T596 |
arg1Of |
binding,DNA |
R488 |
T597 |
T598 |
arg1Of |
binding,of |
R489 |
T597 |
T602 |
arg1Of |
binding,was |
R490 |
T597 |
T603 |
arg2Of |
binding,verified |
R491 |
T599 |
T600 |
arg1Of |
NF-κB,and |
R492 |
T600 |
T598 |
arg2Of |
and,of |
R493 |
T601 |
T600 |
arg2Of |
CREB,and |
R494 |
T603 |
T602 |
arg2Of |
verified,was |
R495 |
T608 |
T603 |
arg1Of |
assay,verified |
R496 |
T608 |
T604 |
arg2Of |
assay,by |
R497 |
T608 |
T605 |
arg1Of |
assay,electrophoretic |
R498 |
T608 |
T606 |
arg1Of |
assay,mobility |
R499 |
T608 |
T607 |
arg1Of |
assay,shift |
R500 |
T610 |
T609 |
arg1Of |
levels,TNF-α |
R501 |
T610 |
T611 |
arg1Of |
levels,were |
R502 |
T610 |
T612 |
arg2Of |
levels,determined |
R503 |
T612 |
T611 |
arg2Of |
determined,were |
R504 |
T612 |
T613 |
arg1Of |
determined,in |
R505 |
T612 |
T619 |
arg1Of |
determined,in |
R506 |
T615 |
T613 |
arg2Of |
supernatant,in |
R507 |
T615 |
T614 |
arg1Of |
supernatant,the |
R508 |
T615 |
T616 |
arg1Of |
supernatant,of |
R509 |
T618 |
T616 |
arg2Of |
cells,of |
R510 |
T618 |
T617 |
arg2Of |
cells,stimulated |
R511 |
T621 |
T622 |
arg1Of |
presence,and |
R512 |
T623 |
T622 |
arg2Of |
absence,and |
R513 |
T627 |
T619 |
arg2Of |
inhibition,in |
R514 |
T627 |
T620 |
arg1Of |
inhibition,the |
R515 |
T627 |
T621 |
arg1Of |
inhibition,presence |
R516 |
T627 |
T623 |
arg1Of |
inhibition,absence |
R517 |
T627 |
T624 |
arg1Of |
inhibition,Protein |
R518 |
T627 |
T625 |
arg1Of |
inhibition,kinase |
R519 |
T627 |
T626 |
arg1Of |
inhibition,A |
R520 |
T627 |
T628 |
arg1Of |
inhibition,by |
R521 |
T632 |
T628 |
arg2Of |
assay,by |
R522 |
T632 |
T629 |
arg1Of |
assay,an |
R523 |
T632 |
T630 |
arg1Of |
assay,enzyme-linked |
R524 |
T632 |
T631 |
arg1Of |
assay,immunosorbent |
R525 |
T632 |
T633 |
arg1Of |
assay,( |
R526 |
T634 |
T633 |
arg2Of |
ELISA,( |
R527 |
T635 |
T633 |
arg3Of |
),( |
R528 |
T637 |
T638 |
arg1Of |
PTX,was |
R529 |
T637 |
T639 |
arg2Of |
PTX,demonstrated |
R530 |
T637 |
T642 |
arg1Of |
PTX,reduce |
R531 |
T639 |
T638 |
arg2Of |
demonstrated,was |
R532 |
T642 |
T639 |
arg3Of |
reduce,demonstrated |
R533 |
T642 |
T640 |
arg1Of |
reduce,to |
R534 |
T642 |
T641 |
arg1Of |
reduce,significantly |
R535 |
T645 |
T643 |
arg1Of |
phosphorylation,cytoplasmic |
R536 |
T645 |
T644 |
arg1Of |
phosphorylation,I-κBα |
R537 |
T645 |
T646 |
arg1Of |
phosphorylation,"," |
R538 |
T646 |
T651 |
arg1Of |
",",and |
R539 |
T649 |
T646 |
arg2Of |
phosphorylation,"," |
R540 |
T649 |
T647 |
arg1Of |
phosphorylation,nuclear |
R541 |
T649 |
T648 |
arg1Of |
phosphorylation,p65 |
R542 |
T651 |
T642 |
arg2Of |
and,reduce |
R543 |
T651 |
T650 |
arg1Of |
and,"," |
R544 |
T655 |
T651 |
arg2Of |
activity,and |
R545 |
T655 |
T652 |
arg1Of |
activity,the |
R546 |
T655 |
T653 |
arg1Of |
activity,DNA |
R547 |
T655 |
T654 |
arg1Of |
activity,binding |
R548 |
T655 |
T656 |
arg1Of |
activity,of |
R549 |
T657 |
T656 |
arg2Of |
NF-κB,of |
R550 |
T659 |
T658 |
arg2Of |
contrast,In |
R551 |
T661 |
T663 |
arg1Of |
PTX,enhanced |
R552 |
T663 |
T658 |
arg1Of |
enhanced,In |
R553 |
T663 |
T660 |
arg1Of |
enhanced,"," |
R554 |
T663 |
T662 |
arg1Of |
enhanced,markedly |
R555 |
T665 |
T666 |
arg1Of |
phosphorylation,and |
R556 |
T666 |
T663 |
arg2Of |
and,enhanced |
R557 |
T666 |
T664 |
arg1Of |
and,the |
R558 |
T666 |
T670 |
arg1Of |
and,of |
R559 |
T669 |
T666 |
arg2Of |
activity,and |
R560 |
T669 |
T667 |
arg1Of |
activity,DNA |
R561 |
T669 |
T668 |
arg1Of |
activity,binding |
R562 |
T671 |
T670 |
arg2Of |
CREB,of |
R563 |
T672 |
T674 |
arg2Of |
Cells,treated |
R564 |
T672 |
T679 |
arg1Of |
Cells,secreted |
R565 |
T674 |
T673 |
arg1Of |
treated,concomitantly |
R566 |
T674 |
T675 |
arg1Of |
treated,with |
R567 |
T676 |
T677 |
arg1Of |
PTX,and |
R568 |
T677 |
T675 |
arg2Of |
and,with |
R569 |
T678 |
T677 |
arg2Of |
LPS,and |
R570 |
T681 |
T679 |
arg2Of |
levels,secreted |
R571 |
T681 |
T680 |
arg1Of |
levels,similar |
R572 |
T681 |
T682 |
arg1Of |
levels,of |
R573 |
T681 |
T684 |
arg1Of |
levels,in |
R574 |
T683 |
T682 |
arg2Of |
TNF-α,of |
R575 |
T686 |
T687 |
arg1Of |
presence,and |
R576 |
T688 |
T687 |
arg2Of |
absence,and |
R577 |
T692 |
T684 |
arg2Of |
inhibition,in |
R578 |
T692 |
T685 |
arg1Of |
inhibition,the |
R579 |
T692 |
T686 |
arg1Of |
inhibition,presence |
R580 |
T692 |
T688 |
arg1Of |
inhibition,absence |
R581 |
T692 |
T689 |
arg1Of |
inhibition,Protein |
R582 |
T692 |
T690 |
arg1Of |
inhibition,kinase |
R583 |
T692 |
T691 |
arg1Of |
inhibition,A |
R584 |
T696 |
T694 |
arg1Of |
level,The |
R585 |
T696 |
T695 |
arg2Of |
level,increased |
R586 |
T696 |
T697 |
arg1Of |
level,of |
R587 |
T696 |
T699 |
arg1Of |
level,that |
R588 |
T696 |
T700 |
arg1Of |
level,results |
R589 |
T696 |
T704 |
arg1Of |
level,affects |
R590 |
T698 |
T697 |
arg2Of |
cAMP,of |
R591 |
T700 |
T701 |
arg1Of |
results,from |
R592 |
T703 |
T701 |
arg2Of |
inhibition,from |
R593 |
T703 |
T702 |
arg1Of |
inhibition,phosphodiesterase |
R594 |
T704 |
T709 |
arg1Of |
affects,"," |
R595 |
T704 |
T710 |
modOf |
affects,resulting |
R596 |
T705 |
T706 |
arg1Of |
cytoplasmic,and |
R597 |
T707 |
T706 |
arg2Of |
nuclear,and |
R598 |
T708 |
T704 |
arg2Of |
events,affects |
R599 |
T708 |
T705 |
arg1Of |
events,cytoplasmic |
R600 |
T708 |
T707 |
arg1Of |
events,nuclear |
R601 |
T710 |
T711 |
arg1Of |
resulting,in |
R602 |
T710 |
T724 |
arg1Of |
resulting,through |
R603 |
T713 |
T712 |
arg1Of |
attenuation,the |
R604 |
T713 |
T714 |
arg1Of |
attenuation,of |
R605 |
T713 |
T716 |
arg1Of |
attenuation,and |
R606 |
T715 |
T714 |
arg2Of |
NF-κB,of |
R607 |
T716 |
T711 |
arg2Of |
and,in |
R608 |
T718 |
T716 |
arg2Of |
activation,and |
R609 |
T718 |
T717 |
arg1Of |
activation,the |
R610 |
T718 |
T719 |
arg1Of |
activation,of |
R611 |
T723 |
T719 |
arg2Of |
binding,of |
R612 |
T723 |
T720 |
arg1Of |
binding,CREB |
R613 |
T723 |
T721 |
arg1Of |
binding,transcriptional |
R614 |
T723 |
T722 |
arg1Of |
binding,DNA |
R615 |
T725 |
T724 |
arg2Of |
pathways,through |
R616 |
T725 |
T726 |
arg1Of |
pathways,that |
R617 |
T725 |
T727 |
arg1Of |
pathways,are |
R618 |
T725 |
T731 |
arg1Of |
pathways,A-independent |
R619 |
T727 |
T728 |
arg1Of |
are,partially |
R620 |
T731 |
T727 |
arg2Of |
A-independent,are |
R621 |
T731 |
T729 |
arg1Of |
A-independent,Protein |
R622 |
T731 |
T730 |
arg1Of |
A-independent,kinase |
R623 |
T735 |
T733 |
arg1Of |
inhibition,PTX-mediated |
R624 |
T735 |
T734 |
arg1Of |
inhibition,phosphodiesterase |
R625 |
T735 |
T736 |
arg1Of |
inhibition,occurs |
R626 |
T735 |
T745 |
arg1Of |
inhibition,may |
R627 |
T735 |
T746 |
arg1Of |
inhibition,serve |
R628 |
T736 |
T737 |
arg1Of |
occurs,partially |
R629 |
T736 |
T738 |
arg1Of |
occurs,through |
R630 |
T736 |
T744 |
arg1Of |
occurs,and |
R631 |
T743 |
T738 |
arg2Of |
pathway,through |
R632 |
T743 |
T739 |
arg1Of |
pathway,a |
R633 |
T743 |
T740 |
arg1Of |
pathway,Protein |
R634 |
T743 |
T741 |
arg1Of |
pathway,kinase |
R635 |
T743 |
T742 |
arg1Of |
pathway,A-independent |
R636 |
T746 |
T744 |
arg2Of |
serve,and |
R637 |
T746 |
T745 |
arg2Of |
serve,may |
R638 |
T746 |
T747 |
arg1Of |
serve,as |
R639 |
T750 |
T747 |
arg2Of |
tool,as |
R640 |
T750 |
T748 |
arg1Of |
tool,a |
R641 |
T750 |
T749 |
arg1Of |
tool,useful |
R642 |
T750 |
T751 |
arg1Of |
tool,in |
R643 |
T753 |
T751 |
arg2Of |
attenuation,in |
R644 |
T753 |
T752 |
arg1Of |
attenuation,the |
R645 |
T753 |
T754 |
arg1Of |
attenuation,of |
R646 |
T756 |
T754 |
arg2Of |
inflammation,of |
R647 |
T756 |
T755 |
arg1Of |
inflammation,LPS-induced |