> top > projects > pmc-enju-pas > docs > PMC:2664230 > annotations
pmc-enju-pas Home  

PMC:2664230 JSONTXT 23 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T451 0-8 NN denotes Insights
T452 9-13 IN denotes into
T453 14-17 DT denotes the
T454 18-28 NN denotes Regulation
T455 29-31 IN denotes of
T456 32-37 NN denotes TNF-α
T457 38-48 NN denotes Production
T458 49-51 IN denotes in
T459 52-57 JJ denotes Human
T460 58-69 JJ denotes Mononuclear
T461 70-75 NN denotes Cells
T462 75-76 -COLON- denotes :
T463 77-80 DT denotes The
T464 81-88 NN denotes Effects
T465 89-91 IN denotes of
T466 92-104 JJ denotes Non-Specific
T467 105-122 NN denotes Phosphodiesterase
T468 123-133 NN denotes Inhibition
T469 145-154 NN denotes OBJECTIVE
T470 155-158 DT denotes The
T471 159-168 NN denotes objective
T472 169-171 IN denotes of
T473 172-176 DT denotes this
T2791 172-176 DT denotes this
T474 177-182 NN denotes study
T2792 177-182 NN denotes study
T475 183-186 VB denotes was
T2793 183-186 VB denotes was
T476 187-189 TO denotes to
T477 190-199 VB denotes determine
T478 200-203 DT denotes the
T479 204-210 NN denotes effect
T480 211-213 IN denotes of
T481 214-225 JJ denotes nonspecific
T482 226-243 NN denotes phosphodiesterase
T483 244-254 NN denotes inhibition
T484 255-257 IN denotes on
T485 258-271 NN denotes transcription
T486 272-278 NN denotes factor
T487 279-289 NN denotes activation
T488 290-293 CC denotes and
T489 294-299 NN denotes tumor
T490 300-308 NN denotes necrosis
T491 309-321 NN denotes factor-alpha
T492 322-323 -LRB- denotes (
T493 323-328 NN denotes TNF-α
T494 328-329 -RRB- denotes )
T495 330-340 NN denotes production
T496 341-343 IN denotes in
T497 344-362 NN denotes lipopolysaccharide
T498 363-364 -LRB- denotes (
T499 364-367 NN denotes LPS
T500 367-368 -RRB- denotes )
T501 368-379 JJ denotes -stimulated
T502 380-385 JJ denotes human
T503 386-397 JJ denotes mononuclear
T504 398-403 NN denotes cells
T505 406-418 NN denotes INTRODUCTION
T506 419-422 DT denotes The
T507 423-433 NN denotes production
T508 434-436 IN denotes of
T509 437-442 NN denotes TNF-α
T510 443-452 VB denotes following
T511 453-456 NN denotes LPS
T512 457-468 NN denotes stimulation
T513 469-471 VB denotes is
T514 472-475 CD denotes one
T515 476-478 IN denotes of
T516 479-482 DT denotes the
T517 483-486 JJ denotes key
T518 487-492 NN denotes steps
T519 493-495 IN denotes in
T520 496-505 JJ denotes bacterial
T521 506-512 NN denotes sepsis
T522 513-516 CC denotes and
T523 517-529 NN denotes inflammation
T524 531-534 DT denotes The
T525 535-544 NN denotes mechanism
T526 545-547 IN denotes by
T527 548-553 WDT denotes which
T528 554-571 NN denotes phosphodiesterase
T529 572-582 NN denotes inhibition
T530 583-589 VB denotes alters
T531 590-595 NN denotes TNF-α
T532 596-606 NN denotes production
T533 607-609 IN denotes in
T534 610-613 DT denotes the
T535 614-622 NN denotes presence
T536 623-625 IN denotes of
T537 626-629 NN denotes LPS
T538 630-637 VB denotes remains
T539 638-645 JJ denotes unclear
T540 648-655 NN denotes METHODS
T541 656-661 JJ denotes Human
T542 662-673 JJ denotes mononuclear
T543 674-679 NN denotes cells
T544 680-684 VB denotes were
T545 685-695 VB denotes stimulated
T546 696-700 IN denotes with
T547 701-704 NN denotes LPS
T548 705-706 -LRB- denotes (
T549 706-707 CD denotes 1
T550 708-713 NN denotes μg/mL
T551 713-714 -RRB- denotes )
T552 714-715 -COMMA- denotes ,
T553 716-718 IN denotes in
T554 719-722 DT denotes the
T555 723-731 NN denotes presence
T556 732-735 CC denotes and
T557 736-743 NN denotes absence
T558 744-746 IN denotes of
T559 747-761 NN denotes Pentoxifylline
T560 762-763 -LRB- denotes (
T561 763-766 NN denotes PTX
T562 766-767 -COLON- denotes ;
T563 768-770 CD denotes 20
T564 771-773 NN denotes mM
T565 773-774 -RRB- denotes )
T566 774-775 -COMMA- denotes ,
T567 776-777 DT denotes a
T568 778-789 JJ denotes nonspecific
T569 790-807 NN denotes phosphodiesterase
T570 808-817 NN denotes inhibitor
T571 819-826 JJ denotes Western
T572 827-835 NN denotes blotting
T573 836-838 IN denotes of
T574 839-853 VB denotes phosphorylated
T575 854-865 JJ denotes cytoplasmic
T576 866-871 NN denotes I-κBα
T577 871-872 -COMMA- denotes ,
T578 873-880 JJ denotes nuclear
T579 881-890 NN denotes factor-κB
T580 891-894 NN denotes p65
T581 895-896 -LRB- denotes (
T582 896-901 NN denotes NF-κB
T583 901-902 -RRB- denotes )
T584 902-903 -COMMA- denotes ,
T585 904-907 CC denotes and
T586 908-915 JJ denotes nuclear
T587 916-929 JJ denotes cAMP-response
T588 930-937 NN denotes element
T589 938-945 NN denotes binding
T590 946-953 NN denotes protein
T591 954-955 -LRB- denotes (
T592 955-959 NN denotes CREB
T593 959-960 -RRB- denotes )
T594 961-964 VB denotes was
T595 965-974 VB denotes performed
T596 976-979 NN denotes DNA
T597 980-987 NN denotes binding
T598 988-990 IN denotes of
T599 991-996 NN denotes NF-κB
T600 997-1000 CC denotes and
T601 1001-1005 NN denotes CREB
T602 1006-1009 VB denotes was
T603 1010-1018 VB denotes verified
T604 1019-1021 IN denotes by
T605 1022-1037 JJ denotes electrophoretic
T606 1038-1046 NN denotes mobility
T607 1047-1052 NN denotes shift
T608 1053-1058 NN denotes assay
T609 1060-1065 NN denotes TNF-α
T610 1066-1072 NN denotes levels
T611 1073-1077 VB denotes were
T612 1078-1088 VB denotes determined
T613 1089-1091 IN denotes in
T614 1092-1095 DT denotes the
T615 1096-1107 NN denotes supernatant
T616 1108-1110 IN denotes of
T617 1111-1121 VB denotes stimulated
T618 1122-1127 NN denotes cells
T619 1128-1130 IN denotes in
T620 1131-1134 DT denotes the
T621 1135-1143 NN denotes presence
T622 1144-1147 CC denotes and
T623 1148-1155 NN denotes absence
T624 1156-1163 NN denotes Protein
T625 1164-1170 NN denotes kinase
T626 1171-1172 NN denotes A
T627 1173-1183 NN denotes inhibition
T628 1184-1186 IN denotes by
T629 1187-1189 DT denotes an
T630 1190-1203 JJ denotes enzyme-linked
T631 1204-1217 JJ denotes immunosorbent
T632 1218-1223 NN denotes assay
T633 1224-1225 -LRB- denotes (
T634 1225-1230 NN denotes ELISA
T635 1230-1231 -RRB- denotes )
T636 1234-1241 NN denotes RESULTS
T637 1242-1245 NN denotes PTX
T638 1246-1249 VB denotes was
T639 1250-1262 VB denotes demonstrated
T640 1263-1265 TO denotes to
T641 1266-1279 RB denotes significantly
T642 1280-1286 VB denotes reduce
T643 1287-1298 JJ denotes cytoplasmic
T644 1299-1304 NN denotes I-κBα
T645 1305-1320 NN denotes phosphorylation
T646 1320-1321 -COMMA- denotes ,
T647 1322-1329 JJ denotes nuclear
T648 1330-1333 NN denotes p65
T649 1334-1349 NN denotes phosphorylation
T650 1349-1350 -COMMA- denotes ,
T651 1351-1354 CC denotes and
T652 1355-1358 DT denotes the
T653 1359-1362 NN denotes DNA
T654 1363-1370 NN denotes binding
T655 1371-1379 NN denotes activity
T656 1380-1382 IN denotes of
T657 1383-1388 NN denotes NF-κB
T658 1390-1392 IN denotes In
T659 1393-1401 NN denotes contrast
T660 1401-1402 -COMMA- denotes ,
T661 1403-1406 NN denotes PTX
T662 1407-1415 RB denotes markedly
T663 1416-1424 VB denotes enhanced
T664 1425-1428 DT denotes the
T665 1429-1444 NN denotes phosphorylation
T666 1445-1448 CC denotes and
T667 1449-1452 NN denotes DNA
T668 1453-1460 NN denotes binding
T669 1461-1469 NN denotes activity
T670 1470-1472 IN denotes of
T671 1473-1477 NN denotes CREB
T672 1479-1484 NN denotes Cells
T673 1485-1498 RB denotes concomitantly
T674 1499-1506 VB denotes treated
T675 1507-1511 IN denotes with
T676 1512-1515 NN denotes PTX
T677 1516-1519 CC denotes and
T678 1520-1523 NN denotes LPS
T679 1524-1532 VB denotes secreted
T680 1533-1540 JJ denotes similar
T681 1541-1547 NN denotes levels
T682 1548-1550 IN denotes of
T683 1551-1556 NN denotes TNF-α
T684 1557-1559 IN denotes in
T685 1560-1563 DT denotes the
T686 1564-1572 NN denotes presence
T687 1573-1576 CC denotes and
T688 1577-1584 NN denotes absence
T689 1585-1592 NN denotes Protein
T690 1593-1599 NN denotes kinase
T691 1600-1601 NN denotes A
T692 1602-1612 NN denotes inhibition
T693 1615-1625 NN denotes DISCUSSION
T694 1626-1629 DT denotes The
T695 1630-1639 VB denotes increased
T696 1640-1645 NN denotes level
T697 1646-1648 IN denotes of
T698 1649-1653 NN denotes cAMP
T699 1654-1658 WDT denotes that
T700 1659-1666 VB denotes results
T701 1667-1671 IN denotes from
T702 1672-1689 NN denotes phosphodiesterase
T703 1690-1700 NN denotes inhibition
T704 1701-1708 VB denotes affects
T705 1709-1720 JJ denotes cytoplasmic
T706 1721-1724 CC denotes and
T707 1725-1732 JJ denotes nuclear
T708 1733-1739 NN denotes events
T709 1739-1740 -COMMA- denotes ,
T710 1741-1750 VB denotes resulting
T711 1751-1753 IN denotes in
T712 1754-1757 DT denotes the
T713 1758-1769 NN denotes attenuation
T714 1770-1772 IN denotes of
T715 1773-1778 NN denotes NF-κB
T716 1779-1782 CC denotes and
T717 1783-1786 DT denotes the
T718 1787-1797 NN denotes activation
T719 1798-1800 IN denotes of
T720 1801-1805 NN denotes CREB
T721 1806-1821 JJ denotes transcriptional
T722 1822-1825 NN denotes DNA
T723 1826-1833 NN denotes binding
T724 1834-1841 IN denotes through
T725 1842-1850 NN denotes pathways
T726 1851-1855 WDT denotes that
T727 1856-1859 VB denotes are
T728 1860-1869 RB denotes partially
T729 1870-1877 NN denotes Protein
T730 1878-1884 NN denotes kinase
T731 1885-1898 JJ denotes A-independent
T732 1901-1911 NN denotes CONCLUSION
T733 1912-1924 JJ denotes PTX-mediated
T734 1925-1942 NN denotes phosphodiesterase
T735 1943-1953 NN denotes inhibition
T736 1954-1960 VB denotes occurs
T737 1961-1970 RB denotes partially
T738 1971-1978 IN denotes through
T739 1979-1980 DT denotes a
T740 1981-1988 NN denotes Protein
T741 1989-1995 NN denotes kinase
T742 1996-2009 JJ denotes A-independent
T743 2010-2017 NN denotes pathway
T744 2018-2021 CC denotes and
T745 2022-2025 MD denotes may
T746 2026-2031 VB denotes serve
T747 2032-2034 IN denotes as
T748 2035-2036 DT denotes a
T749 2037-2043 JJ denotes useful
T750 2044-2048 NN denotes tool
T751 2049-2051 IN denotes in
T752 2052-2055 DT denotes the
T753 2056-2067 NN denotes attenuation
T754 2068-2070 IN denotes of
T755 2071-2082 JJ denotes LPS-induced
T756 2083-2095 NN denotes inflammation
T1612 2112-2115 DT denotes The
T1613 2116-2125 JJ denotes bacterial
T1614 2126-2134 NN denotes membrane
T1615 2135-2144 NN denotes component
T1616 2145-2163 NN denotes lipopolysaccharide
T1617 2164-2165 -LRB- denotes (
T1618 2165-2168 NN denotes LPS
T1619 2168-2169 -RRB- denotes )
T1620 2170-2172 VB denotes is
T1621 2173-2180 JJ denotes capable
T1622 2181-2183 IN denotes of
T1623 2184-2194 VB denotes initiating
T1624 2195-2210 NN denotes phosphorylation
T1625 2211-2214 CC denotes and
T1626 2215-2225 NN denotes activation
T1627 2226-2228 IN denotes of
T1628 2229-2237 JJ denotes multiple
T1629 2238-2242 NN denotes host
T1630 2243-2256 JJ denotes intracellular
T1631 2257-2264 NN denotes protein
T1632 2265-2272 NN denotes kinases
T1633 2273-2276 CC denotes and
T1634 2277-2290 NN denotes transcription
T1635 2291-2298 NN denotes factors
T1636 2300-2313 NN denotes Transcription
T1637 2314-2320 NN denotes factor
T1638 2321-2331 NN denotes activation
T1639 2331-2332 -COMMA- denotes ,
T1640 2333-2338 WDT denotes which
T1641 2339-2346 VB denotes results
T1642 2347-2349 IN denotes in
T1643 2350-2353 DT denotes the
T1644 2354-2364 NN denotes modulation
T1645 2365-2367 IN denotes of
T1646 2368-2372 NN denotes gene
T1647 2373-2386 NN denotes transcription
T1648 2387-2390 CC denotes and
T1649 2391-2398 NN denotes protein
T1650 2399-2408 NN denotes synthesis
T1651 2408-2409 -COMMA- denotes ,
T1652 2410-2412 VB denotes is
T1653 2413-2414 DT denotes a
T1654 2415-2423 JJ denotes critical
T1655 2424-2431 NN denotes element
T1656 2432-2434 IN denotes in
T1657 2435-2438 DT denotes the
T1658 2439-2446 NN denotes defense
T1659 2447-2456 NN denotes mechanism
T1660 2457-2459 IN denotes of
T1661 2460-2463 DT denotes the
T1662 2464-2468 NN denotes host
T1663 2469-2475 JJ denotes immune
T1664 2476-2486 NN denotes system.1,2
T1665 2487-2498 JJ denotes LPS-induced
T1666 2499-2512 NN denotes transcription
T1667 2513-2519 NN denotes factor
T1668 2520-2530 NN denotes activation
T1669 2531-2534 VB denotes has
T1670 2535-2539 VB denotes been
T1671 2540-2545 VB denotes shown
T1672 2546-2548 TO denotes to
T1673 2549-2551 VB denotes be
T1674 2552-2553 DT denotes a
T1675 2554-2557 JJ denotes key
T1676 2558-2567 NN denotes regulator
T1677 2568-2570 IN denotes of
T1678 2571-2576 NN denotes tumor
T1679 2577-2585 NN denotes necrosis
T1680 2586-2594 NN denotes factor-α
T1681 2595-2596 -LRB- denotes (
T1682 2596-2601 NN denotes TNF-α
T1683 2601-2602 -RRB- denotes )
T1684 2603-2615 NN denotes production.3
T1685 2616-2621 NN denotes TNF-α
T1686 2622-2624 VB denotes is
T1687 2625-2626 DT denotes a
T1688 2627-2633 JJ denotes potent
T1689 2634-2650 JJ denotes pro-inflammatory
T1690 2651-2659 NN denotes cytokine
T1691 2660-2668 VB denotes involved
T1692 2669-2671 IN denotes in
T1693 2672-2673 DT denotes a
T1694 2674-2678 JJ denotes wide
T1695 2679-2687 NN denotes spectrum
T1696 2688-2690 IN denotes of
T1697 2691-2699 JJ denotes cellular
T1698 2700-2709 NN denotes responses
T1699 2711-2722 RB denotes Furthermore
T1700 2722-2723 -COMMA- denotes ,
T1701 2724-2729 NN denotes TNF-α
T1702 2730-2739 NN denotes synthesis
T1703 2740-2743 MD denotes can
T1704 2744-2746 VB denotes be
T1705 2747-2757 VB denotes attenuated
T1706 2758-2760 IN denotes in
T1707 2761-2767 JJ denotes immune
T1708 2768-2773 NN denotes cells
T1709 2774-2781 VB denotes exposed
T1710 2782-2784 TO denotes to
T1711 2785-2802 NN denotes phosphodiesterase
T1712 2803-2804 -LRB- denotes (
T1713 2804-2807 NN denotes PDE
T1714 2807-2808 -RRB- denotes )
T1715 2809-2819 NN denotes inhibition
T1716 2820-2825 IN denotes after
T1717 2826-2835 NN denotes challenge
T1718 2836-2838 IN denotes by
T1719 2839-2840 DT denotes a
T1720 2841-2848 NN denotes variety
T1721 2849-2851 IN denotes of
T1722 2852-2868 JJ denotes pro-inflammatory
T1723 2869-2881 NN denotes stimulants.4
T1724 2882-2885 DT denotes The
T1725 2886-2895 NN denotes signaling
T1726 2896-2906 NN denotes mechanisms
T1727 2907-2915 VB denotes affected
T1728 2916-2918 IN denotes by
T1729 2919-2922 NN denotes PDE
T1730 2923-2933 NN denotes inhibition
T1731 2933-2934 -COMMA- denotes ,
T1732 2935-2940 WDT denotes which
T1733 2941-2951 RB denotes ultimately
T1734 2952-2956 VB denotes lead
T1735 2957-2959 TO denotes to
T1736 2960-2963 DT denotes the
T1737 2964-2978 NN denotes downregulation
T1738 2979-2981 IN denotes of
T1739 2982-2987 NN denotes TNF-α
T1740 2988-2998 NN denotes production
T1741 2998-2999 -COMMA- denotes ,
T1742 3000-3004 VB denotes have
T1743 3005-3008 RB denotes not
T1744 3009-3013 VB denotes been
T1745 3014-3018 RB denotes well
T1746 3019-3032 VB denotes characterized
T1747 3033-3035 IN denotes in
T1748 3036-3048 JJ denotes inflammatory
T1749 3049-3054 NN denotes cells
T1750 3056-3067 RB denotes Classically
T1751 3067-3068 -COMMA- denotes ,
T1752 3069-3071 PRP denotes it
T1753 3072-3075 VB denotes has
T1754 3076-3080 VB denotes been
T1755 3081-3093 VB denotes demonstrated
T1756 3094-3098 IN denotes that
T1757 3099-3102 NN denotes PDE
T1758 3103-3113 NN denotes inhibition
T1759 3114-3121 VB denotes results
T1760 3122-3124 IN denotes in
T1761 3125-3128 DT denotes the
T1762 3129-3142 JJ denotes intracellular
T1763 3143-3155 NN denotes accumulation
T1764 3156-3158 IN denotes of
T1765 3159-3162 DT denotes the
T1766 3163-3169 JJ denotes second
T1767 3170-3179 NN denotes messenger
T1768 3180-3186 JJ denotes cyclic
T1769 3187-3214 NN denotes adenosine-3,5-monophosphate
T1770 3215-3216 -LRB- denotes (
T1771 3216-3220 NN denotes cAMP
T1772 3220-3221 -RRB- denotes )
T1773 3222-3225 CC denotes and
T1774 3226-3236 JJ denotes subsequent
T1775 3237-3247 NN denotes activation
T1776 3248-3250 IN denotes of
T1777 3251-3258 NN denotes Protein
T1778 3259-3265 NN denotes kinase
T1779 3266-3267 NN denotes A
T1780 3268-3269 -LRB- denotes (
T1781 3269-3272 NN denotes PKA
T1782 3272-3273 -RRB- denotes )
T1783 3273-3275 CD denotes .5
T1784 3276-3279 NN denotes PKA
T1785 3280-3290 NN denotes activation
T1786 3291-3295 RB denotes then
T1787 3296-3301 VB denotes leads
T1788 3302-3304 TO denotes to
T1789 3305-3308 DT denotes the
T1790 3309-3324 NN denotes phosphorylation
T1791 3325-3327 IN denotes of
T1792 3328-3331 DT denotes the
T1793 3332-3345 NN denotes transcription
T1794 3346-3352 NN denotes factor
T1795 3353-3366 JJ denotes cAMP-response
T1796 3367-3374 NN denotes element
T1797 3375-3382 NN denotes binding
T1798 3383-3390 NN denotes protein
T1799 3391-3392 -LRB- denotes (
T1800 3392-3396 NN denotes CREB
T1801 3396-3397 -RRB- denotes )
T1802 3397-3398 -COMMA- denotes ,
T1803 3399-3411 NN denotes transmission
T1804 3412-3414 IN denotes of
T1805 3415-3422 NN denotes signals
T1806 3423-3427 IN denotes into
T1807 3428-3431 DT denotes the
T1808 3432-3439 NN denotes nucleus
T1809 3439-3440 -COMMA- denotes ,
T1810 3441-3444 CC denotes and
T1811 3445-3448 DT denotes the
T1812 3449-3459 JJ denotes subsequent
T1813 3460-3470 NN denotes modulation
T1814 3471-3473 IN denotes of
T1815 3474-3478 NN denotes gene
T1816 3479-3494 NN denotes transcription.6
T1817 3495-3499 DT denotes This
T1818 3500-3510 RB denotes apparently
T1819 3511-3517 JJ denotes simple
T1820 3518-3524 JJ denotes linear
T1821 3525-3532 NN denotes cascade
T1822 3533-3537 VB denotes does
T1823 3538-3541 RB denotes not
T1824 3542-3547 RB denotes fully
T1825 3548-3555 VB denotes explain
T1826 3556-3559 DT denotes the
T1827 3560-3569 NN denotes mechanism
T1828 3570-3572 IN denotes by
T1829 3573-3578 WDT denotes which
T1830 3579-3581 DT denotes an
T1831 3582-3591 NN denotes elevation
T1832 3592-3594 IN denotes in
T1833 3595-3598 DT denotes the
T1834 3599-3612 JJ denotes intracellular
T1835 3613-3617 NN denotes cAMP
T1836 3618-3623 NN denotes level
T1837 3624-3630 VB denotes exerts
T1838 3631-3643 JJ denotes wide-ranging
T1839 3644-3651 NN denotes effects
T1840 3652-3654 IN denotes on
T1841 3655-3663 JJ denotes multiple
T1842 3664-3672 JJ denotes cellular
T1843 3673-3682 NN denotes functions
T1844 3684-3689 EX denotes There
T1845 3690-3692 VB denotes is
T1846 3693-3694 DT denotes a
T1847 3695-3702 VB denotes growing
T1848 3703-3707 NN denotes body
T1849 3708-3710 IN denotes of
T1850 3711-3719 NN denotes evidence
T1851 3720-3730 VB denotes suggesting
T1852 3731-3735 IN denotes that
T1853 3736-3740 NN denotes cAMP
T1854 3741-3744 MD denotes may
T1855 3745-3753 VB denotes function
T1856 3754-3761 IN denotes through
T1857 3762-3766 CC denotes both
T1858 3767-3780 JJ denotes PKA-dependent
T1859 3781-3784 CC denotes and
T1860 3785-3797 JJ denotes -independent
T1861 3798-3812 NN denotes mechanisms.6–8
T1862 3813-3824 JJ denotes LPS-induced
T1863 3825-3835 NN denotes activation
T1864 3836-3838 IN denotes of
T1865 3839-3842 DT denotes the
T1866 3843-3856 NN denotes transcription
T1867 3857-3863 NN denotes factor
T1868 3864-3871 JJ denotes nuclear
T1869 3872-3881 NN denotes factor-κB
T1870 3882-3883 -LRB- denotes (
T1871 3883-3888 NN denotes NF-κB
T1872 3888-3889 -RRB- denotes )
T1873 3890-3893 VB denotes has
T1874 3894-3898 RB denotes also
T1875 3899-3903 VB denotes been
T1876 3904-3907 DT denotes the
T1877 3908-3913 NN denotes focus
T1878 3914-3916 IN denotes of
T1879 3917-3918 DT denotes a
T1880 3919-3924 JJ denotes great
T1881 3925-3929 NN denotes deal
T1882 3930-3932 IN denotes of
T1883 3933-3941 NN denotes research
T1884 3943-3945 PRP denotes It
T1885 3946-3949 VB denotes has
T1886 3950-3954 VB denotes been
T1887 3955-3962 RB denotes clearly
T1888 3963-3975 VB denotes demonstrated
T1889 3976-3980 IN denotes that
T1890 3981-3987 NN denotes agents
T1891 3988-3992 WDT denotes that
T1892 3993-4001 VB denotes increase
T1893 4002-4015 JJ denotes intracellular
T1894 4016-4020 NN denotes cAMP
T1895 4021-4025 RB denotes also
T1896 4026-4033 VB denotes inhibit
T1897 4034-4049 JJ denotes NF-κB-dependent
T1898 4050-4066 JJ denotes pro-inflammatory
T1899 4067-4071 NN denotes gene
T1900 4072-4085 NN denotes transcription
T1901 4085-4086 -COMMA- denotes ,
T1902 4087-4099 RB denotes particularly
T1903 4100-4102 IN denotes of
T1904 4103-4106 DT denotes the
T1905 4107-4112 NN denotes TNF-α
T1906 4113-4119 NN denotes gene.9
T1907 4120-4131 NNP denotes Controversy
T1908 4132-4138 VB denotes exists
T1909 4139-4148 VB denotes regarding
T1910 4149-4152 DT denotes the
T1911 4153-4158 JJ denotes exact
T1912 4159-4168 NN denotes mechanism
T1913 4168-4169 -LRB- denotes (
T1914 4169-4170 NN denotes s
T1915 4170-4171 -RRB- denotes )
T1916 4172-4174 IN denotes by
T1917 4175-4180 WDT denotes which
T1918 4181-4184 NN denotes PDE
T1919 4185-4195 NN denotes inhibition
T1920 4196-4210 VB denotes down-regulates
T1921 4211-4216 NN denotes TNF-α
T1922 4217-4227 NN denotes production
T1923 4229-4242 NN denotes Possibilities
T1924 4243-4250 VB denotes include
T1925 4250-4251 -COMMA- denotes ,
T1926 4252-4255 CC denotes but
T1927 4256-4259 VB denotes are
T1928 4260-4263 RB denotes not
T1929 4264-4271 VB denotes limited
T1930 4272-4274 TO denotes to
T1931 4274-4275 -COMMA- denotes ,
T1932 4276-4286 NN denotes inhibition
T1933 4287-4289 IN denotes of
T1934 4290-4295 NN denotes NF-κB
T1935 4296-4299 NN denotes DNA
T1936 4300-4307 NN denotes binding
T1937 4308-4316 NN denotes activity
T1938 4316-4317 -COMMA- denotes ,
T1939 4318-4332 NN denotes downregulation
T1940 4333-4335 IN denotes of
T1941 4336-4341 NN denotes NF-κB
T1942 4342-4357 JJ denotes transcriptional
T1943 4358-4366 NN denotes activity
T1944 4366-4367 -COMMA- denotes ,
T1945 4368-4377 VB denotes increased
T1946 4378-4382 NN denotes CREB
T1947 4383-4393 NN denotes activation
T1948 4393-4394 -COMMA- denotes ,
T1949 4395-4398 CC denotes and
T1950 4399-4410 NN denotes competition
T1951 4411-4418 IN denotes between
T1952 4419-4424 NN denotes NF-κB
T1953 4425-4428 CC denotes and
T1954 4429-4433 NN denotes CREB
T1955 4434-4437 IN denotes for
T1956 4438-4444 JJ denotes common
T1957 4445-4458 NN denotes co-activators
T1958 4459-4463 JJ denotes such
T1959 4464-4466 IN denotes as
T1960 4467-4471 NN denotes CREB
T1961 4472-4479 NN denotes binding
T1962 4480-4487 NN denotes protein
T1963 4488-4489 -LRB- denotes (
T1964 4489-4492 NN denotes CBP
T1965 4492-4493 -RRB- denotes )
T1966 4495-4497 PRP denotes It
T1967 4498-4500 VB denotes is
T1968 4501-4505 RB denotes also
T1969 4506-4509 RB denotes not
T1970 4510-4515 VB denotes known
T1971 4516-4523 IN denotes whether
T1972 4524-4529 DT denotes these
T1973 4530-4539 NN denotes processes
T1974 4540-4544 VB denotes rely
T1975 4545-4551 RB denotes solely
T1976 4552-4556 IN denotes upon
T1977 4557-4560 DT denotes the
T1978 4561-4571 NN denotes activation
T1979 4572-4574 IN denotes of
T1980 4575-4578 NN denotes PKA
T1981 4580-4589 RB denotes Therefore
T1982 4589-4590 -COMMA- denotes ,
T1983 4591-4594 DT denotes the
T1984 4595-4604 NN denotes objective
T1985 4605-4607 IN denotes of
T1986 4608-4611 DT denotes the
T1987 4612-4619 JJ denotes present
T1988 4620-4625 NN denotes study
T1989 4626-4628 VB denotes is
T1990 4629-4631 TO denotes to
T1991 4632-4641 VB denotes determine
T1992 4642-4645 DT denotes the
T1993 4646-4653 NN denotes effects
T1994 4654-4656 IN denotes of
T1995 4657-4668 JJ denotes nonspecific
T1996 4669-4672 NN denotes PDE
T1997 4673-4683 NN denotes inhibition
T1998 4684-4688 IN denotes with
T1999 4689-4691 NN denotes 1-
T2000 4691-4692 -LRB- denotes [
T2001 4692-4702 NN denotes 5-oxohexyl
T2002 4702-4703 -RRB- denotes ]
T2003 4703-4724 NN denotes -3,7-dimethylxanthine
T2004 4725-4726 -LRB- denotes (
T2005 4726-4740 NN denotes Pentoxifylline
T2006 4740-4741 -COLON- denotes ;
T2007 4742-4745 NN denotes PTX
T2008 4745-4746 -RRB- denotes )
T2009 4747-4749 IN denotes on
T2010 4750-4755 NN denotes NF-κB
T2011 4756-4759 CC denotes and
T2012 4760-4764 NN denotes CREB
T2013 4765-4775 NN denotes activation
T2014 4776-4778 FW denotes in
T2015 4779-4784 FW denotes vitro
T2016 4785-4787 IN denotes in
T2017 4788-4793 JJ denotes human
T2018 4794-4805 JJ denotes mononuclear
T2019 4806-4811 NN denotes cells
T2020 4813-4817 IN denotes With
T2021 4818-4821 DT denotes the
T2022 4822-4825 NN denotes use
T2023 4826-4828 IN denotes of
T2024 4829-4837 JJ denotes specific
T2025 4838-4848 NN denotes inhibitors
T2026 4848-4849 -COMMA- denotes ,
T2027 4850-4852 PRP denotes we
T2028 4853-4857 RB denotes also
T2029 4858-4870 VB denotes investigated
T2030 4871-4874 DT denotes the
T2031 4875-4879 NN denotes role
T2032 4880-4882 IN denotes of
T2033 4883-4886 NN denotes PKA
T2034 4887-4889 IN denotes in
T2035 4890-4901 JJ denotes LPS-induced
T2036 4902-4907 NN denotes TNF-α
T2037 4908-4918 NN denotes production
T2794 4958-4966 VB denotes approved
T2795 4967-4969 IN denotes by
T2796 4970-4973 DT denotes the
T2797 4974-4979 NNP denotes Human
T2798 4980-4988 NNP denotes Research
T2799 4989-5000 NNP denotes Protections
T2800 5001-5008 NNP denotes Program
T2801 5009-5012 CC denotes and
T2802 5013-5016 DT denotes the
T2803 5017-5030 NNP denotes Institutional
T2804 5031-5037 NNP denotes Review
T2805 5038-5044 NNP denotes Board.
T2806 5045-5052 NNP denotes Written
T2807 5053-5060 NN denotes consent
T2808 5061-5063 TO denotes to
T2809 5064-5075 VB denotes participate
T2810 5076-5078 IN denotes in
T2811 5079-5082 DT denotes the
T2812 5083-5088 NN denotes study
T2813 5089-5092 VB denotes was
T2814 5093-5101 VB denotes obtained
T2815 5102-5106 IN denotes from
T2816 5107-5110 DT denotes all
T2817 5111-5121 NN denotes volunteers
T2818 5122-5127 RB denotes prior
T2819 5128-5130 TO denotes to
T2820 5131-5136 NN denotes blood
T2821 5137-5158 JJ denotes donation. Heparinized
T2822 5159-5170 NN denotes Vacutainers
T2823 5171-5175 VB denotes were
T2824 5176-5185 VB denotes purchased
T2825 5186-5190 IN denotes from
T2826 5191-5197 NNP denotes Becton
T2827 5198-5207 NNP denotes Dickinson
T2828 5208-5209 -LRB- denotes (
T2829 5209-5212 NNP denotes San
T2830 5213-5217 NNP denotes Jose
T2831 5217-5218 -COMMA- denotes ,
T2832 5219-5221 NNP denotes CA
T2833 5221-5222 -RRB- denotes )
T2834 5224-5230 NN denotes 1.5-mL
T2835 5231-5240 NNP denotes Eppendorf
T2836 5241-5251 NN denotes centrifuge
T2837 5252-5257 NN denotes tubes
T2838 5258-5262 VB denotes were
T2839 5263-5272 VB denotes purchased
T2840 5273-5277 IN denotes from
T2841 5278-5284 NNP denotes Fisher
T2842 5285-5295 NNP denotes Scientific
T2843 5296-5297 -LRB- denotes (
T2844 5297-5306 NNP denotes Pittsburg
T2845 5306-5307 -COMMA- denotes ,
T2846 5308-5310 NNP denotes PA
T2847 5310-5311 -RRB- denotes )
T2848 5313-5319 NN denotes Hank’s
T2849 5320-5328 JJ denotes balanced
T2850 5329-5333 NN denotes salt
T2851 5334-5342 NN denotes solution
T2852 5343-5344 -LRB- denotes (
T2853 5344-5348 NN denotes HBSS
T2854 5348-5349 -RRB- denotes )
T2855 5350-5353 CC denotes and
T2856 5354-5358 NN denotes RPMI
T2857 5359-5363 CD denotes 1640
T2858 5364-5368 VB denotes were
T2859 5369-5377 VB denotes obtained
T2860 5378-5382 IN denotes from
T2861 5383-5389 NNP denotes Irvine
T2862 5390-5400 NNP denotes Scientific
T2863 5401-5402 -LRB- denotes (
T2864 5402-5407 NNP denotes Santa
T2865 5408-5411 NNP denotes Ana
T2866 5411-5412 -COMMA- denotes ,
T2867 5413-5415 NNP denotes CA
T2868 5415-5416 -RRB- denotes )
T2869 5418-5421 NN denotes LPS
T2870 5422-5438 NN denotes from Escherichia
T2871 5439-5452 NN denotes coli serotype
T2872 5453-5457 CD denotes 0111
T2873 5457-5458 -COLON- denotes :
T2874 5458-5460 NN denotes B4
T2875 5461-5464 CC denotes and
T2876 5465-5468 NN denotes PTX
T2877 5469-5473 VB denotes were
T2878 5474-5483 VB denotes purchased
T2879 5484-5488 IN denotes from
T2880 5489-5494 NN denotes Sigma
T2881 5495-5496 -LRB- denotes (
T2882 5496-5499 NNP denotes St.
T2883 5500-5505 NNP denotes Louis
T2884 5505-5506 -COMMA- denotes ,
T2885 5507-5509 NN denotes MO
T2886 5509-5510 -RRB- denotes )
T2887 5512-5515 DT denotes The
T2888 5516-5519 NN denotes PKA
T2889 5520-5529 NN denotes inhibitor
T2890 5529-5530 -COMMA- denotes ,
T2891 5531-5533 NN denotes N-
T2892 5533-5534 -LRB- denotes [
T2893 5534-5536 CD denotes 2-
T2894 5536-5537 -LRB- denotes (
T2895 5537-5538 -LRB- denotes (
T2896 5538-5553 NN denotes p-bromocinnamyl
T2897 5553-5554 -RRB- denotes )
T2898 5554-5559 NN denotes amino
T2899 5559-5560 -RRB- denotes )
T2900 5560-5565 NN denotes ethyl
T2901 5565-5566 -RRB- denotes ]
T2902 5566-5597 NN denotes -5-isoguinolinesulfonamide-2HCl
T2903 5597-5598 -RRB- denotes ]
T2904 5599-5600 -LRB- denotes (
T2905 5600-5603 NN denotes H89
T2906 5603-5604 -RRB- denotes )
T2907 5604-5605 -COMMA- denotes ,
T2908 5606-5609 VB denotes was
T2909 5610-5619 VB denotes purchased
T2910 5620-5624 IN denotes from
T2911 5625-5635 NN denotes Calbiochem
T2912 5636-5637 -LRB- denotes (
T2913 5637-5639 NNP denotes La
T2914 5640-5645 NNP denotes Jolla
T2915 5645-5646 -COMMA- denotes ,
T2916 5647-5649 NNP denotes CA
T2917 5649-5650 -RRB- denotes )
T2918 5652-5662 NN denotes Antibodies
T2919 5663-5666 IN denotes for
T2920 5667-5681 VB denotes phosphorylated
T2921 5682-5686 NN denotes CREB
T2922 5687-5688 -LRB- denotes (
T2923 5688-5694 NN denotes serine
T2924 5695-5698 CD denotes 133
T2925 5698-5699 -RRB- denotes )
T2926 5699-5700 -COMMA- denotes ,
T2927 5701-5715 VB denotes phosphorylated
T2928 5716-5721 NN denotes I-κBα
T2929 5722-5723 -LRB- denotes (
T2930 5723-5730 NN denotes serines
T2931 5731-5733 CD denotes 32
T2932 5734-5737 CC denotes and
T2933 5738-5740 CD denotes 36
T2934 5740-5741 -RRB- denotes )
T2935 5741-5742 -COMMA- denotes ,
T2936 5743-5757 VB denotes phosphorylated
T2937 5758-5763 NN denotes NF-κB
T2938 5764-5767 NN denotes p65
T2939 5768-5775 NN denotes subunit
T2940 5776-5777 -LRB- denotes (
T2941 5777-5783 NN denotes serine
T2942 5784-5787 CD denotes 276
T2943 5787-5788 -RRB- denotes )
T2944 5788-5789 -COMMA- denotes ,
T2945 5790-5793 CC denotes and
T2946 5794-5803 JJ denotes secondary
T2947 5804-5814 NN denotes antibodies
T2948 5815-5819 VB denotes were
T2949 5820-5829 VB denotes purchased
T2950 5830-5834 IN denotes from
T2951 5835-5839 NN denotes Cell
T2952 5840-5849 NN denotes Signaling
T2953 5850-5851 -LRB- denotes (
T2954 5851-5858 NNP denotes Beverly
T2955 5858-5859 -COMMA- denotes ,
T2956 5860-5862 JJ denotes MA
T2957 5862-5863 -RRB- denotes )
T2958 5863-5872 NN denotes . Dextran
T2959 5873-5877 NN denotes T500
T2960 5878-5881 CC denotes and
T2961 5882-5889 NN denotes Percoll
T2962 5890-5894 VB denotes were
T2963 5895-5903 VB denotes received
T2964 5904-5908 IN denotes from
T2965 5909-5911 NNP denotes GE
T2966 5912-5931 NNP denotes Healthcare/Amersham
T2967 5932-5943 NNP denotes Biosciences
T2968 5944-5945 -LRB- denotes (
T2969 5945-5955 NNP denotes Piscataway
T2970 5955-5956 -COMMA- denotes ,
T2971 5957-5959 NNP denotes NJ
T2972 5959-5960 -RRB- denotes )
T2973 5962-5965 DT denotes The
T2974 5966-5979 JJ denotes enzyme-linked
T2975 5980-5993 JJ denotes immunosorbent
T2976 5994-5999 NN denotes assay
T2977 6000-6001 -LRB- denotes (
T2978 6001-6006 NN denotes ELISA
T2979 6006-6007 -RRB- denotes )
T2980 6008-6011 IN denotes for
T2981 6012-6017 NN denotes TNF-α
T2982 6018-6021 VB denotes was
T2983 6022-6030 VB denotes obtained
T2984 6031-6035 IN denotes from
T2985 6036-6046 NNP denotes Quantikine
T2986 6047-6048 NNP denotes R
T2987 6048-6049 CC denotes &
T2988 6049-6050 NNP denotes D
T2989 6051-6058 NNP denotes Systems
T2990 6059-6060 -LRB- denotes (
T2991 6060-6071 NNP denotes Minneapolis
T2992 6071-6072 -COMMA- denotes ,
T2993 6073-6075 NN denotes MN
T2994 6075-6076 -RRB- denotes )
T2995 6076-6090 NN denotes . Tris-glycine
T2996 6091-6094 CC denotes and
T2997 6095-6098 NN denotes DNA
T2998 6099-6110 NN denotes retardation
T2999 6111-6115 NN denotes gels
T3000 6115-6116 -COMMA- denotes ,
T3001 6117-6131 NN denotes nitrocellulose
T3002 6132-6141 NN denotes membranes
T3003 6141-6142 -COMMA- denotes ,
T3004 6143-6146 CC denotes and
T3005 6147-6154 JJ denotes western
T3006 6155-6159 NN denotes blot
T3007 6160-6167 VB denotes running
T3008 6168-6175 NN denotes buffers
T3009 6176-6180 VB denotes were
T3010 6181-6189 VB denotes obtained
T3011 6190-6194 IN denotes from
T3012 6195-6205 NN denotes Invitrogen
T3013 6206-6207 -LRB- denotes (
T3014 6207-6215 NNP denotes Carlsbad
T3015 6215-6216 -COMMA- denotes ,
T3016 6217-6219 NN denotes CA
T3017 6219-6220 -RRB- denotes )
T3018 6222-6237 JJ denotes NE-PER® nuclear
T3019 6238-6241 CC denotes and
T3020 6242-6253 JJ denotes cytoplasmic
T3021 6254-6264 NN denotes extraction
T3022 6265-6273 NN denotes reagents
T3023 6273-6274 -COMMA- denotes ,
T3024 6275-6278 DT denotes the
T3025 6279-6282 NN denotes BCA
T3026 6283-6290 NN denotes protein
T3027 6291-6298 NN denotes reagent
T3028 6299-6302 NN denotes kit
T3029 6302-6303 -COMMA- denotes ,
T3030 6304-6307 DT denotes the
T3031 6308-6319 NNP denotes Supersignal
T3032 6320-6324 NNP denotes West
T3033 6325-6329 NNP denotes Pico
T3034 6330-6346 NNP denotes Chemiluminescent
T3035 6347-6350 NNP denotes Kit
T3036 6350-6351 -COMMA- denotes ,
T3037 6352-6355 CC denotes and
T3038 6356-6359 DT denotes the
T3039 6360-6370 NNP denotes LightShift
T3040 6371-6387 NNP denotes Chemiluminescent
T3041 6388-6392 NNP denotes EMSA
T3042 6393-6396 NN denotes Kit
T3043 6397-6401 VB denotes were
T3044 6402-6411 VB denotes purchased
T3045 6412-6416 IN denotes from
T3046 6417-6423 NNP denotes Pierce
T3047 6424-6425 -LRB- denotes (
T3048 6425-6433 NNP denotes Rockland
T3049 6433-6434 -COMMA- denotes ,
T3050 6435-6437 NN denotes IL
T3051 6437-6438 -RRB- denotes )
T3052 6440-6444 NN denotes CREB
T3053 6445-6448 CC denotes and
T3054 6449-6454 NN denotes NF-κB
T3055 6455-6458 NN denotes DNA
T3056 6459-6474 NN denotes oligonucleotide
T3057 6475-6481 NN denotes probes
T3058 6482-6486 VB denotes were
T3059 6487-6498 VB denotes synthesized
T3060 6499-6501 IN denotes by
T3061 6502-6505 NN denotes IDT
T3062 6506-6507 -LRB- denotes (
T3063 6507-6517 NNP denotes Coralville
T3064 6517-6518 -COMMA- denotes ,
T3065 6519-6521 NNP denotes IA
T3066 6521-6522 -RRB- denotes )
T3067 6524-6529 NN denotes Nylon
T3068 6530-6539 NN denotes membranes
T3069 6540-6544 VB denotes were
T3070 6545-6554 VB denotes purchased
T3071 6555-6559 IN denotes from
T3072 6560-6565 NNP denotes Roche
T3073 6566-6573 NNP denotes Applied
T3074 6574-6582 NNP denotes Sciences
T3075 6583-6584 -LRB- denotes (
T3076 6584-6596 NNP denotes Indianapolis
T3077 6596-6597 -COMMA- denotes ,
T3078 6598-6600 NNP denotes IN
T3079 6600-6601 -RRB- denotes )
T3080 6603-6610 NN denotes Western
T3081 6611-6615 NN denotes blot
T3082 6616-6620 NN denotes band
T3083 6621-6635 NN denotes quantification
T3084 6636-6639 VB denotes was
T3085 6640-6649 VB denotes performed
T3086 6650-6654 IN denotes with
T3087 6655-6658 DT denotes the
T3088 6659-6669 NNP denotes UN-SCAN-IT
T3089 6670-6673 NNP denotes Gel
T3090 6674-6684 NNP denotes Digitizing
T3091 6685-6693 NN denotes software
T3092 6694-6695 -LRB- denotes (
T3093 6695-6699 NNP denotes Silk
T3094 6700-6710 NNP denotes Scientific
T3095 6710-6711 -COMMA- denotes ,
T3096 6712-6716 NNP denotes Orem
T3097 6716-6717 -COMMA- denotes ,
T3098 6718-6720 NN denotes UT
T3099 6720-6721 -RRB- denotes )
T3577 6724-6729 JJ denotes Human
T3578 6730-6740 NNP denotes Peripheral
T3579 6741-6746 NNP denotes Blood
T3580 6747-6758 NNP denotes Mononuclear
T3581 6759-6763 NNP denotes Cell
T3582 6764-6773 NN denotes Isolation
T3583 6774-6777 CC denotes and
T3584 6778-6789 NN denotes Stimulation
T3585 6790-6795 JJ denotes Human
T3586 6796-6807 JJ denotes mononuclear
T3587 6808-6813 NN denotes cells
T3588 6814-6818 VB denotes were
T3589 6819-6827 VB denotes isolated
T3590 6828-6832 IN denotes from
T3591 6833-6836 DT denotes the
T3592 6837-6847 JJ denotes peripheral
T3593 6848-6853 NN denotes blood
T3594 6854-6856 IN denotes of
T3595 6857-6861 CD denotes four
T3596 6862-6869 JJ denotes healthy
T3597 6870-6875 JJ denotes human
T3598 6876-6886 NN denotes volunteers
T3599 6888-6891 DT denotes The
T3600 6892-6898 NN denotes sample
T3601 6899-6903 NN denotes size
T3602 6904-6907 VB denotes was
T3603 6908-6914 VB denotes chosen
T3604 6915-6919 IN denotes from
T3605 6920-6923 PRP-DOLLAR- denotes our
T3606 6924-6934 RB denotes previously
T3607 6935-6944 VB denotes published
T3608 6945-6949 NN denotes work
T3609 6949-6950 -COMMA- denotes ,
T3610 6951-6956 WDT denotes which
T3611 6957-6969 VB denotes demonstrated
T3612 6970-6978 JJ denotes reliable
T3613 6979-6989 NN denotes results.10
T3614 6990-6994 NN denotes Cell
T3615 6995-7004 NN denotes isolation
T3616 7005-7008 CC denotes and
T3617 7009-7012 DT denotes all
T3618 7013-7023 JJ denotes subsequent
T3619 7024-7035 NN denotes experiments
T3620 7036-7040 VB denotes were
T3621 7041-7050 VB denotes conducted
T3622 7051-7056 IN denotes under
T3623 7057-7064 JJ denotes sterile
T3624 7065-7068 CC denotes and
T3625 7069-7081 JJ denotes pyrogen-free
T3626 7082-7092 NN denotes conditions
T3627 7094-7099 NN denotes Blood
T3628 7100-7109 VB denotes collected
T3629 7110-7112 IN denotes in
T3630 7113-7120 NN denotes heparin
T3631 7121-7126 NN denotes tubes
T3632 7127-7130 VB denotes was
T3633 7131-7140 VB denotes incubated
T3634 7141-7145 IN denotes with
T3635 7146-7153 NN denotes Dextran
T3636 7154-7158 NN denotes T500
T3637 7159-7162 CC denotes and
T3638 7163-7166 DT denotes the
T3639 7167-7170 JJ denotes red
T3640 7171-7176 NN denotes cells
T3641 7177-7181 VB denotes were
T3642 7182-7192 VB denotes sedimented
T3643 7193-7196 IN denotes for
T3644 7197-7199 CD denotes 40
T3645 7200-7207 NN denotes minutes
T3646 7208-7210 IN denotes at
T3647 7211-7215 NN denotes room
T3648 7216-7227 NN denotes temperature
T3649 7229-7232 DT denotes The
T3650 7233-7242 JJ denotes resultant
T3651 7243-7248 NN denotes serum
T3652 7249-7252 VB denotes was
T3653 7253-7257 RB denotes then
T3654 7258-7264 VB denotes washed
T3655 7265-7269 IN denotes with
T3656 7270-7274 NN denotes HBSS
T3657 7275-7278 CC denotes and
T3658 7279-7288 VB denotes separated
T3659 7289-7291 IN denotes by
T3660 7292-7299 NNP denotes Percoll
T3661 7300-7308 NN denotes gradient
T3662 7309-7323 NN denotes centrifugation
T3663 7324-7333 VB denotes according
T3664 7334-7336 TO denotes to
T3665 7337-7340 DT denotes the
T3666 7341-7355 NN denotes manufacturer’s
T3667 7356-7368 NN denotes instructions
T3668 7370-7374 NN denotes Cell
T3669 7375-7384 NN denotes viability
T3670 7385-7388 VB denotes was
T3671 7389-7397 VB denotes assessed
T3672 7398-7400 IN denotes by
T3673 7401-7407 NN denotes trypan
T3674 7408-7412 JJ denotes blue
T3675 7413-7416 NN denotes dye
T3676 7417-7426 NN denotes exclusion
T3677 7426-7427 -COMMA- denotes ,
T3678 7428-7432 IN denotes with
T3679 7433-7439 NN denotes purity
T3680 7440-7442 IN denotes of
T3681 7443-7450 JJ denotes greater
T3682 7451-7455 IN denotes than
T3683 7456-7458 CD denotes 95
T3684 7458-7459 NN denotes %
T3685 7461-7469 VB denotes Isolated
T3686 7470-7475 NN denotes cells
T3687 7476-7480 VB denotes were
T3688 7481-7492 VB denotes resuspended
T3689 7493-7495 IN denotes in
T3690 7496-7500 NN denotes RPMI
T3691 7501-7505 CD denotes 1640
T3692 7506-7518 VB denotes supplemented
T3693 7519-7523 IN denotes with
T3694 7524-7526 CD denotes 10
T3695 7526-7527 NN denotes %
T3696 7528-7531 NN denotes FBS
T3697 7532-7535 CC denotes and
T3698 7536-7537 CD denotes 5
T3699 7538-7540 NN denotes mM
T3700 7541-7546 NN denotes HEPES
T3701 7547-7549 IN denotes at
T3702 7550-7551 DT denotes a
T3703 7552-7565 NN denotes concentration
T3704 7566-7568 IN denotes of
T3705 7569-7570 CD denotes 1
T3706 7571-7572 SYM denotes x
T3707 7573-7584 NN denotes 107cells/mL
T3708 7586-7590 DT denotes Each
T3709 7591-7601 JJ denotes subsequent
T3710 7602-7612 NN denotes experiment
T3711 7613-7619 VB denotes listed
T3712 7620-7625 IN denotes below
T3713 7626-7629 VB denotes was
T3714 7630-7639 VB denotes conducted
T3715 7640-7642 IN denotes on
T3716 7643-7650 NN denotes samples
T3717 7651-7653 IN denotes of
T3718 7654-7655 CD denotes 5
T3719 7656-7657 NN denotes x
T3720 7658-7661 CD denotes 106
T3721 7662-7667 NN denotes cells
T3722 7668-7671 IN denotes per
T3723 7672-7681 NN denotes treatment
T3724 7682-7687 NN denotes group
T3725 7689-7697 VB denotes Isolated
T3726 7698-7703 NN denotes cells
T3727 7704-7708 VB denotes were
T3728 7709-7719 VB denotes stimulated
T3729 7720-7724 IN denotes with
T3730 7725-7731 CC denotes either
T3731 7732-7736 NN denotes HBSS
T3732 7737-7739 IN denotes as
T3733 7740-7741 DT denotes a
T3734 7742-7750 JJ denotes negative
T3735 7751-7758 NN denotes control
T3736 7758-7759 -COMMA- denotes ,
T3737 7760-7763 NN denotes LPS
T3738 7764-7765 -LRB- denotes (
T3739 7765-7766 CD denotes 1
T3740 7767-7772 NN denotes μg/mL
T3741 7772-7773 -RRB- denotes )
T3742 7773-7774 -COMMA- denotes ,
T3743 7775-7778 NN denotes PTX
T3744 7779-7780 -LRB- denotes (
T3745 7780-7782 CD denotes 20
T3746 7783-7785 NN denotes mM
T3747 7785-7786 -RRB- denotes )
T3748 7786-7787 -COMMA- denotes ,
T3749 7788-7790 CC denotes or
T3750 7791-7802 JJ denotes concomitant
T3751 7803-7806 NN denotes LPS
T3752 7807-7808 SYM denotes /
T3753 7809-7812 NN denotes PTX
T3754 7812-7813 -COMMA- denotes ,
T3755 7814-7816 IN denotes at
T3756 7817-7820 DT denotes the
T3757 7821-7836 JJ denotes above-mentioned
T3758 7837-7851 NN denotes concentrations
T3759 7851-7852 -COMMA- denotes ,
T3760 7853-7856 IN denotes for
T3761 7857-7859 CD denotes 30
T3762 7860-7867 NN denotes minutes
T3763 7868-7870 IN denotes at
T3764 7871-7875 NN denotes 37ºC
T3765 7877-7882 NN denotes Cells
T3766 7883-7887 VB denotes were
T3767 7888-7894 VB denotes placed
T3768 7895-7897 IN denotes on
T3769 7898-7901 NN denotes ice
T3770 7902-7905 IN denotes for
T3771 7906-7908 CD denotes 10
T3772 7909-7916 NN denotes minutes
T3773 7917-7919 TO denotes to
T3774 7920-7924 VB denotes stop
T3775 7925-7928 DT denotes the
T3776 7929-7937 NN denotes reaction
T3777 7938-7941 CC denotes and
T3778 7942-7945 DT denotes the
T3779 7946-7953 NN denotes samples
T3780 7954-7958 VB denotes were
T3781 7959-7963 RB denotes then
T3782 7964-7970 VB denotes stored
T3783 7971-7973 IN denotes at
T3784 7974-7979 NN denotes −70°C
T3785 7980-7983 IN denotes for
T3786 7984-7991 JJ denotes further
T3787 7992-8000 NN denotes analysis
T3788 8002-8005 DT denotes The
T3789 8006-8017 NN denotes stimulation
T3790 8018-8023 NN denotes times
T3791 8024-8027 CC denotes and
T3792 8028-8042 NN denotes concentrations
T3793 8043-8045 IN denotes of
T3794 8046-8049 NN denotes LPS
T3795 8050-8053 CC denotes and
T3796 8054-8057 NN denotes PTX
T3797 8058-8066 VB denotes utilized
T3798 8067-8069 IN denotes in
T3799 8070-8074 DT denotes this
T3800 8075-8080 NN denotes study
T3801 8081-8085 VB denotes were
T3802 8086-8096 VB denotes determined
T3803 8097-8099 IN denotes in
T3804 8100-8108 JJ denotes previous
T3805 8109-8114 NN denotes pilot
T3806 8115-8122 NN denotes studies
T3807 8123-8127 VB denotes done
T3808 8128-8130 IN denotes in
T3809 8131-8134 PRP-DOLLAR- denotes our
T3810 8135-8145 NN denotes laboratory
T3811 8145-8146 -COMMA- denotes ,
T3812 8147-8152 WDT denotes which
T3813 8153-8161 VB denotes examined
T3814 8162-8165 DT denotes the
T3815 8166-8173 NN denotes effects
T3816 8174-8176 IN denotes of
T3817 8177-8187 VB denotes increasing
T3818 8188-8202 NN denotes concentrations
T3819 8203-8205 IN denotes of
T3820 8206-8209 NN denotes PTX
T3821 8210-8212 IN denotes on
T3822 8213-8224 JJ denotes LPS-induced
T3823 8225-8230 NN denotes TNF-α
T3824 8231-8241 NN denotes production
T3825 8243-8246 NN denotes LPS
T3826 8247-8249 IN denotes at
T3827 8250-8251 DT denotes a
T3828 8252-8265 NN denotes concentration
T3829 8266-8268 IN denotes of
T3830 8269-8270 CD denotes 1
T3831 8271-8276 NN denotes μg/mL
T3832 8277-8280 CC denotes and
T3833 8281-8284 NN denotes PTX
T3834 8285-8287 IN denotes at
T3835 8288-8289 DT denotes a
T3836 8290-8303 NN denotes concentration
T3837 8304-8306 IN denotes of
T3838 8307-8309 CD denotes 20
T3839 8310-8312 NN denotes mM
T3840 8313-8317 VB denotes were
T3841 8318-8321 DT denotes the
T3842 8322-8329 JJ denotes minimum
T3843 8330-8344 NN denotes concentrations
T3844 8345-8354 JJ denotes necessary
T3845 8355-8357 TO denotes to
T3846 8358-8365 VB denotes produce
T3847 8366-8367 DT denotes a
T3848 8368-8380 JJ denotes reproducible
T3849 8381-8384 CC denotes and
T3850 8385-8393 JJ denotes reliable
T3851 8394-8407 NN denotes up-regulation
T3852 8408-8411 CC denotes and
T3853 8412-8427 NN denotes down-regulation
T3854 8428-8430 IN denotes in
T3855 8431-8436 NN denotes TNF-α
T3856 8437-8447 NN denotes production
T3857 8447-8448 -COMMA- denotes ,
T3858 8449-8461 RB denotes respectively
T3859 8461-8462 -COMMA- denotes ,
T3860 8463-8465 IN denotes in
T3861 8466-8478 JJ denotes quantitative
T3862 8479-8485 NN denotes assays
T3863 8486-8487 -LRB- denotes (
T3864 8487-8491 NN denotes data
T3865 8492-8495 RB denotes not
T3866 8496-8501 VB denotes shown
T3867 8501-8502 -RRB- denotes )
T4023 8505-8511 NN denotes Effect
T4024 8512-8514 IN denotes of
T4025 8515-8518 NN denotes PTX
T4026 8519-8521 IN denotes on
T4027 8522-8533 JJ denotes LPS-induced
T4028 8534-8539 NN denotes TNF-α
T4029 8540-8550 NN denotes production
T4030 8551-8553 IN denotes by
T4031 8554-8565 JJ denotes mononuclear
T4032 8566-8571 NN denotes cells
T4033 8572-8575 DT denotes The
T4034 8576-8589 NN denotes concentration
T4035 8590-8592 IN denotes of
T4036 8593-8598 NN denotes TNF-α
T4037 8599-8602 VB denotes was
T4038 8603-8617 RB denotes quantitatively
T4039 8618-8628 VB denotes determined
T4040 8629-8631 IN denotes by
T4041 8632-8637 NN denotes ELISA
T4042 8638-8640 IN denotes in
T4043 8641-8644 DT denotes the
T4044 8645-8650 NN denotes media
T4045 8651-8653 IN denotes of
T4046 8654-8659 NN denotes cells
T4047 8660-8667 VB denotes exposed
T4048 8668-8670 TO denotes to
T4049 8671-8674 DT denotes the
T4050 8675-8685 NN denotes treatments
T4051 8686-8695 VB denotes described
T4052 8696-8701 IN denotes above
T4053 8702-8707 IN denotes after
T4054 8708-8719 NN denotes stimulation
T4055 8720-8723 IN denotes for
T4056 8724-8726 RB denotes up
T4057 8727-8729 TO denotes to
T4058 8730-8731 DT denotes a
T4059 8732-8739 NN denotes maximum
T4060 8740-8742 IN denotes of
T4061 8743-8745 CD denotes 18
T4062 8746-8751 NN denotes hours
T4063 8751-8752 -COMMA- denotes ,
T4064 8753-8755 IN denotes at
T4065 8756-8762 JJ denotes 3-hour
T4066 8763-8772 NN denotes intervals
T4067 8774-8777 DT denotes The
T4068 8778-8785 NN denotes results
T4069 8786-8789 VB denotes are
T4070 8790-8799 VB denotes expressed
T4071 8800-8802 IN denotes in
T4072 8803-8808 NN denotes pg/mL
T4475 8811-8819 NN denotes SDS-PAGE
T4476 8820-8823 CC denotes and
T4477 8824-8838 NN denotes Immunoblotting
T4478 8839-8840 -LRB- denotes (
T4479 8840-8845 NN denotes I-κBα
T4480 8845-8846 -COMMA- denotes ,
T4481 8847-8852 NN denotes NF-κB
T4482 8853-8856 NN denotes p65
T4483 8856-8857 -COMMA- denotes ,
T4484 8858-8861 CC denotes and
T4485 8862-8866 NN denotes CREB
T4486 8866-8867 -RRB- denotes )
T4487 8868-8877 VB denotes Following
T4488 8878-8889 NN denotes stimulation
T4489 8889-8890 -COMMA- denotes ,
T4490 8891-8896 NN denotes PBMCs
T4491 8897-8901 VB denotes were
T4492 8902-8908 VB denotes washed
T4493 8909-8913 IN denotes with
T4494 8914-8922 JJ denotes ice-cold
T4495 8923-8926 NN denotes PBS
T4496 8927-8930 CC denotes and
T4497 8931-8942 VB denotes centrifuged
T4498 8943-8945 TO denotes to
T4499 8946-8953 VB denotes collect
T4500 8954-8955 DT denotes a
T4501 8956-8960 NN denotes cell
T4502 8961-8967 NN denotes pellet
T4503 8969-8972 DT denotes The
T4504 8973-8979 NN denotes pellet
T4505 8980-8983 VB denotes was
T4506 8984-8995 VB denotes resuspended
T4507 8996-8998 IN denotes in
T4508 8999-9007 JJ denotes ice-cold
T4509 9008-9011 NN denotes SDS
T4510 9012-9018 NN denotes sample
T4511 9019-9025 NN denotes buffer
T4512 9026-9038 VB denotes supplemented
T4513 9039-9043 IN denotes with
T4514 9044-9047 CD denotes 100
T4515 9048-9050 NN denotes mM
T4516 9051-9065 NN denotes dithiothreitol
T4517 9067-9078 JJ denotes Cytoplasmic
T4518 9079-9082 CC denotes and
T4519 9083-9090 JJ denotes nuclear
T4520 9091-9099 NN denotes extracts
T4521 9100-9104 VB denotes were
T4522 9105-9113 VB denotes isolated
T4523 9114-9118 IN denotes with
T4524 9119-9125 NN denotes NE-PER
T4525 9126-9133 JJ denotes nuclear
T4526 9134-9137 CC denotes and
T4527 9138-9149 JJ denotes cytoplasmic
T4528 9150-9160 NN denotes extraction
T4529 9161-9169 NN denotes reagents
T4530 9170-9174 IN denotes with
T4531 9175-9177 NN denotes 1x
T4532 9178-9182 NNP denotes Halt
T4533 9183-9191 NNP denotes Protease
T4534 9192-9201 NNP denotes Inhibitor
T4535 9202-9210 NNP denotes Cocktail
T4536 9211-9220 VB denotes according
T4537 9221-9223 TO denotes to
T4538 9224-9227 DT denotes the
T4539 9228-9242 NN denotes manufacturer’s
T4540 9243-9255 NN denotes instructions
T4541 9257-9264 NN denotes Protein
T4542 9265-9279 NN denotes concentrations
T4543 9280-9284 VB denotes were
T4544 9285-9295 VB denotes determined
T4545 9296-9300 IN denotes with
T4546 9301-9304 DT denotes the
T4547 9305-9308 NN denotes BCA
T4548 9309-9316 NN denotes protein
T4549 9317-9324 NN denotes reagent
T4550 9325-9328 NN denotes kit
T4551 9329-9332 IN denotes for
T4552 9333-9337 DT denotes each
T4553 9338-9344 NN denotes sample
T4554 9345-9354 VB denotes according
T4555 9355-9357 TO denotes to
T4556 9358-9359 DT denotes a
T4557 9360-9372 JJ denotes standardized
T4558 9373-9378 NN denotes curve
T4559 9379-9382 IN denotes for
T4560 9383-9390 NN denotes albumin
T4561 9392-9396 NN denotes Cell
T4562 9397-9404 NN denotes lysates
T4563 9405-9409 VB denotes were
T4564 9410-9419 VB denotes collected
T4565 9420-9422 IN denotes by
T4566 9423-9430 VB denotes boiling
T4567 9431-9434 DT denotes the
T4568 9435-9442 NN denotes samples
T4569 9443-9445 IN denotes in
T4570 9446-9447 DT denotes a
T4571 9448-9453 NN denotes 100ºC
T4572 9454-9459 NN denotes water
T4573 9460-9464 NN denotes bath
T4574 9465-9468 IN denotes for
T4575 9469-9470 CD denotes 5
T4576 9471-9478 NN denotes minutes
T4577 9480-9483 CD denotes Ten
T4578 9484-9486 NN denotes μg
T4579 9487-9489 IN denotes of
T4580 9490-9497 NN denotes protein
T4581 9498-9501 IN denotes per
T4582 9502-9508 NN denotes sample
T4583 9509-9512 VB denotes was
T4584 9513-9522 VB denotes separated
T4585 9523-9525 IN denotes by
T4586 9526-9544 NN denotes SDS-polyacrylamide
T4587 9545-9548 NN denotes gel
T4588 9549-9564 NN denotes electrophoresis
T4589 9565-9572 IN denotes through
T4590 9573-9577 CD denotes 8–16
T4591 9577-9578 NN denotes %
T4592 9579-9591 NN denotes tris-glycine
T4593 9592-9606 NN denotes polyacrylamide
T4594 9607-9615 NN denotes gradient
T4595 9616-9620 NN denotes gels
T4596 9621-9624 CC denotes and
T4597 9625-9636 VB denotes transferred
T4598 9637-9639 TO denotes to
T4599 9640-9654 VB denotes nitrocellulose
T4600 9655-9664 NN denotes membranes
T4601 9666-9669 DT denotes The
T4602 9670-9679 NN denotes membranes
T4603 9680-9684 VB denotes were
T4604 9685-9692 VB denotes blocked
T4605 9693-9697 IN denotes with
T4606 9698-9699 CD denotes 5
T4607 9699-9700 NN denotes %
T4608 9701-9705 NN denotes milk
T4609 9706-9708 IN denotes in
T4610 9709-9722 JJ denotes Tris-buffered
T4611 9723-9735 NN denotes saline/Tween
T4612 9736-9738 CD denotes 20
T4613 9739-9740 -LRB- denotes (
T4614 9740-9747 NNP denotes Fischer
T4615 9748-9758 NNP denotes Scientific
T4616 9758-9759 -COMMA- denotes ,
T4617 9760-9770 NNP denotes Pittsburgh
T4618 9770-9771 -COMMA- denotes ,
T4619 9772-9774 NNP denotes PA
T4620 9774-9775 -RRB- denotes )
T4621 9776-9779 IN denotes for
T4622 9780-9781 CD denotes 1
T4623 9782-9786 NN denotes hour
T4624 9788-9799 JJ denotes Cytoplasmic
T4625 9800-9808 NN denotes extracts
T4626 9809-9813 VB denotes were
T4627 9814-9823 VB denotes incubated
T4628 9824-9828 IN denotes with
T4629 9829-9843 VB denotes phosphorylated
T4630 9844-9849 JJ denotes I-κBα
T4631 9850-9858 NN denotes antibody
T4632 9859-9860 -LRB- denotes (
T4633 9860-9861 CD denotes 1
T4634 9861-9862 -COLON- denotes :
T4635 9862-9865 CD denotes 200
T4636 9865-9866 -RRB- denotes )
T4637 9866-9867 -COMMA- denotes ,
T4638 9868-9873 IN denotes while
T4639 9874-9881 JJ denotes nuclear
T4640 9882-9890 NN denotes extracts
T4641 9891-9895 VB denotes were
T4642 9896-9905 VB denotes incubated
T4643 9906-9910 IN denotes with
T4644 9911-9917 CC denotes either
T4645 9918-9932 VB denotes phosphorylated
T4646 9933-9938 NN denotes NF-κB
T4647 9939-9942 NN denotes p65
T4648 9943-9951 NN denotes antibody
T4649 9952-9953 -LRB- denotes (
T4650 9953-9954 CD denotes 1
T4651 9954-9955 -COLON- denotes :
T4652 9955-9958 CD denotes 500
T4653 9958-9959 -RRB- denotes )
T4654 9960-9962 CC denotes or
T4655 9963-9977 VB denotes phosphorylated
T4656 9978-9982 NN denotes CREB
T4657 9983-9991 NN denotes antibody
T4658 9992-9993 -LRB- denotes (
T4659 9993-9994 CD denotes 1
T4660 9994-9995 -COLON- denotes :
T4661 9995-9998 CD denotes 500
T4662 9998-9999 -RRB- denotes )
T4663 10000-10009 RB denotes overnight
T4664 10010-10012 IN denotes at
T4665 10013-10016 NN denotes 4°C
T4666 10017-10019 IN denotes in
T4667 10020-10028 JJ denotes separate
T4668 10029-10040 NN denotes experiments
T4669 10042-10045 DT denotes The
T4670 10046-10055 NN denotes membranes
T4671 10056-10060 VB denotes were
T4672 10061-10067 VB denotes washed
T4673 10068-10072 IN denotes with
T4674 10073-10086 JJ denotes Tris-buffered
T4675 10087-10099 NN denotes saline/Tween
T4676 10100-10102 CD denotes 20
T4677 10103-10106 CC denotes and
T4678 10107-10116 VB denotes incubated
T4679 10117-10120 IN denotes for
T4680 10121-10122 CD denotes 1
T4681 10123-10127 NN denotes hour
T4682 10128-10130 IN denotes at
T4683 10131-10135 NN denotes room
T4684 10136-10147 NN denotes temperature
T4685 10148-10152 IN denotes with
T4686 10153-10156 DT denotes the
T4687 10157-10166 JJ denotes secondary
T4688 10167-10175 NN denotes antibody
T4689 10175-10176 -COMMA- denotes ,
T4690 10177-10188 JJ denotes horseradish
T4691 10189-10206 JJ denotes peroxidase-linked
T4692 10207-10218 JJ denotes anti-rabbit
T4693 10219-10222 NN denotes IgG
T4694 10223-10230 VB denotes diluted
T4695 10231-10232 CD denotes 1
T4696 10232-10233 -COLON- denotes :
T4697 10233-10237 CD denotes 2000
T4698 10238-10240 IN denotes in
T4699 10241-10249 VB denotes blocking
T4700 10250-10258 NN denotes solution
T4701 10260-10265 IN denotes After
T4702 10266-10274 VB denotes repeated
T4703 10275-10282 NN denotes washing
T4704 10283-10285 IN denotes of
T4705 10286-10289 DT denotes the
T4706 10290-10298 NN denotes membrane
T4707 10298-10299 -COMMA- denotes ,
T4708 10300-10303 DT denotes the
T4709 10304-10315 NNP denotes Supersignal
T4710 10316-10320 NNP denotes West
T4711 10321-10325 NNP denotes Pico
T4712 10326-10342 NNP denotes Chemiluminescent
T4713 10343-10346 NNP denotes Kit
T4714 10347-10350 VB denotes was
T4715 10351-10358 VB denotes applied
T4716 10359-10362 IN denotes for
T4717 10363-10371 NN denotes antibody
T4718 10372-10381 NN denotes detection
T4719 10382-10385 IN denotes per
T4720 10386-10389 DT denotes the
T4721 10390-10404 NN denotes manufacturer’s
T4722 10405-10417 NN denotes instructions
T4723 10419-10426 JJ denotes Western
T4724 10427-10431 NN denotes blot
T4725 10432-10436 NN denotes data
T4726 10437-10439 VB denotes is
T4727 10440-10449 VB denotes presented
T4728 10450-10452 IN denotes as
T4729 10453-10454 DT denotes a
T4730 10455-10465 NN denotes percentage
T4731 10466-10468 IN denotes of
T4732 10469-10472 NN denotes LPS
T4733 10473-10484 NN denotes stimulation
T4734 10486-10489 DT denotes The
T4735 10490-10500 NN denotes percentage
T4736 10501-10503 IN denotes of
T4737 10504-10507 NN denotes LPS
T4738 10508-10519 NN denotes stimulation
T4739 10520-10523 VB denotes was
T4740 10524-10534 VB denotes calculated
T4741 10535-10537 IN denotes by
T4742 10538-10546 VB denotes dividing
T4743 10547-10550 DT denotes the
T4744 10551-10555 JJ denotes mean
T4745 10556-10560 NN denotes band
T4746 10561-10566 NN denotes pixel
T4747 10567-10572 NN denotes total
T4748 10573-10576 IN denotes for
T4749 10577-10581 DT denotes each
T4750 10582-10591 NN denotes treatment
T4751 10592-10595 NN denotes arm
T4752 10596-10603 VB denotes divided
T4753 10604-10606 IN denotes by
T4754 10607-10610 DT denotes the
T4755 10611-10615 JJ denotes mean
T4756 10616-10621 NN denotes pixel
T4757 10622-10627 NN denotes total
T4758 10628-10630 IN denotes of
T4759 10631-10638 NN denotes samples
T4760 10639-10649 VB denotes stimulated
T4761 10650-10654 IN denotes with
T4762 10655-10658 NN denotes LPS
T4763 10659-10662 CC denotes and
T4764 10663-10674 VB denotes multiplying
T4765 10675-10677 IN denotes by
T4766 10678-10681 CD denotes 100
T4767 10683-10687 RB denotes Thus
T4768 10687-10688 -COMMA- denotes ,
T4769 10689-10692 NN denotes LPS
T4770 10693-10704 NN denotes stimulation
T4771 10705-10707 VB denotes is
T4772 10708-10716 VB denotes reported
T4773 10717-10719 IN denotes as
T4774 10720-10723 CD denotes 100
T4775 10723-10724 NN denotes %
T4776 10725-10728 CC denotes and
T4777 10729-10733 DT denotes each
T4778 10734-10736 IN denotes of
T4779 10737-10740 DT denotes the
T4780 10741-10750 NN denotes treatment
T4781 10751-10755 NN denotes arms
T4782 10756-10758 VB denotes is
T4783 10759-10767 VB denotes reported
T4784 10768-10770 IN denotes as
T4785 10771-10772 DT denotes a
T4786 10773-10780 NN denotes percent
T4787 10781-10783 IN denotes of
T4788 10784-10787 NN denotes LPS
T4789 10788-10799 NN denotes stimulation
T5231 10802-10807 NN denotes NF-κB
T5232 10808-10811 CC denotes and
T5233 10812-10816 NN denotes CREB
T5234 10817-10832 JJ denotes Electrophoretic
T5235 10833-10841 NN denotes Mobility
T5236 10842-10847 NN denotes Shift
T5237 10848-10853 NN denotes Assay
T5238 10854-10855 -LRB- denotes (
T5239 10855-10859 NN denotes EMSA
T5240 10859-10860 -RRB- denotes )
T5241 10861-10864 DT denotes The
T5242 10865-10880 JJ denotes non-radioactive
T5243 10881-10891 NNP denotes LightShift
T5244 10892-10908 NNP denotes Chemiluminescent
T5245 10909-10913 NNP denotes EMSA
T5246 10914-10917 NN denotes Kit
T5247 10918-10921 VB denotes was
T5248 10922-10926 VB denotes used
T5249 10927-10929 TO denotes to
T5250 10930-10936 VB denotes detect
T5251 10937-10948 JJ denotes DNA-protein
T5252 10949-10961 NN denotes interactions
T5253 10963-10966 DT denotes The
T5254 10967-10972 NN denotes NF-κB
T5255 10973-10975 NN denotes 3′
T5256 10976-10982 NN denotes biotin
T5257 10983-10994 JJ denotes end-labeled
T5258 10995-10998 NN denotes DNA
T5259 10999-11014 NN denotes oligonucleotide
T5260 11015-11019 VB denotes used
T5261 11020-11022 IN denotes as
T5262 11023-11024 DT denotes a
T5263 11025-11030 NN denotes probe
T5264 11031-11034 IN denotes for
T5265 11035-11038 DT denotes the
T5266 11039-11043 NN denotes EMSA
T5267 11044-11047 VB denotes was
T5268 11048-11049 DT denotes a
T5269 11050-11055 JJ denotes 42-bp
T5270 11056-11062 JJ denotes double
T5271 11063-11071 JJ denotes stranded
T5272 11072-11081 NN denotes construct
T5273 11082-11083 -LRB- denotes (
T5274 11083-11129 NN denotes 5′-TTGTTACAA-GGGGACTTTCCGCTGGGGACTTTCCAGGGAGGC
T5275 11130-11131 NN denotes –
T5276 11132-11134 NN denotes 3′
T5277 11134-11135 -RRB- denotes )
T5278 11136-11146 VB denotes containing
T5279 11147-11150 CD denotes two
T5280 11151-11159 RB denotes tandemly
T5281 11160-11168 VB denotes repeated
T5282 11169-11174 NN denotes NF-κB
T5283 11175-11182 NN denotes binding
T5284 11183-11188 NN denotes sites
T5285 11189-11190 -LRB- denotes (
T5286 11190-11200 VB denotes underlined
T5287 11200-11201 -RRB- denotes )
T5288 11203-11214 NN denotes Specificity
T5289 11215-11218 VB denotes was
T5290 11219-11229 VB denotes determined
T5291 11230-11232 IN denotes by
T5292 11233-11234 DT denotes a
T5293 11235-11246 NN denotes competition
T5294 11247-11252 NN denotes assay
T5295 11253-11257 IN denotes with
T5296 11258-11261 DT denotes the
T5297 11262-11270 NN denotes addition
T5298 11271-11273 IN denotes of
T5299 11274-11277 CD denotes 200
T5300 11278-11283 JJ denotes molar
T5301 11284-11290 NN denotes excess
T5302 11291-11293 IN denotes of
T5303 11294-11303 JJ denotes unlabeled
T5304 11304-11310 JJ denotes double
T5305 11311-11319 JJ denotes stranded
T5306 11320-11325 NN denotes NF-κB
T5307 11326-11341 NN denotes oligonucleotide
T5308 11343-11346 DT denotes The
T5309 11347-11351 NN denotes CREB
T5310 11352-11354 NN denotes 3′
T5311 11355-11361 NN denotes biotin
T5312 11362-11373 JJ denotes end-labeled
T5313 11374-11377 NN denotes DNA
T5314 11378-11393 NN denotes oligonucleotide
T5315 11394-11398 VB denotes used
T5316 11399-11401 IN denotes as
T5317 11402-11403 DT denotes a
T5318 11404-11409 NN denotes probe
T5319 11410-11413 IN denotes for
T5320 11414-11417 DT denotes the
T5321 11418-11422 NN denotes EMSA
T5322 11423-11426 VB denotes was
T5323 11427-11428 DT denotes a
T5324 11429-11434 JJ denotes 23-bp
T5325 11435-11441 JJ denotes double
T5326 11442-11450 JJ denotes stranded
T5327 11451-11460 NN denotes construct
T5328 11461-11462 -LRB- denotes (
T5329 11462-11468 NN denotes 5′-TTT
T5330 11469-11472 NN denotes TCG
T5331 11473-11476 NN denotes AGC
T5332 11477-11492 NN denotes TCTGACGTCAGA-GC
T5333 11493-11494 NN denotes –
T5334 11495-11497 NN denotes 3′
T5335 11497-11498 -RRB- denotes )
T5336 11499-11509 VB denotes containing
T5337 11510-11513 DT denotes the
T5338 11514-11517 NN denotes CRE
T5339 11518-11527 NN denotes consensus
T5340 11528-11536 NN denotes sequence
T5341 11537-11538 -LRB- denotes (
T5342 11538-11548 VB denotes underlined
T5343 11548-11549 -RRB- denotes )
T5344 11551-11562 NN denotes Specificity
T5345 11563-11566 VB denotes was
T5346 11567-11577 VB denotes determined
T5347 11578-11580 IN denotes by
T5348 11581-11582 DT denotes a
T5349 11583-11594 NN denotes competition
T5350 11595-11600 NN denotes assay
T5351 11601-11605 IN denotes with
T5352 11606-11609 DT denotes the
T5353 11610-11618 NN denotes addition
T5354 11619-11621 IN denotes of
T5355 11622-11625 CD denotes 200
T5356 11626-11631 JJ denotes molar
T5357 11632-11638 NN denotes excess
T5358 11639-11641 IN denotes of
T5359 11642-11651 JJ denotes unlabeled
T5360 11652-11658 JJ denotes double
T5361 11659-11667 JJ denotes stranded
T5362 11668-11672 NN denotes CREB
T5363 11673-11688 NN denotes oligonucleotide
T5364 11690-11697 JJ denotes Nuclear
T5365 11698-11706 NN denotes extracts
T5366 11707-11708 -LRB- denotes (
T5367 11708-11710 CD denotes 10
T5368 11711-11713 NN denotes μg
T5369 11713-11714 -RRB- denotes )
T5370 11715-11719 VB denotes were
T5371 11720-11729 VB denotes incubated
T5372 11730-11734 IN denotes with
T5373 11735-11736 CD denotes 5
T5374 11737-11739 NN denotes nM
T5375 11740-11745 NN denotes NF-κB
T5376 11746-11748 CC denotes or
T5377 11749-11753 NN denotes CREB
T5378 11754-11759 NN denotes probe
T5379 11760-11761 -LRB- denotes (
T5380 11761-11766 NN denotes NF-kB
T5381 11766-11767 -COLON- denotes :
T5382 11768-11770 NN denotes 1x
T5383 11771-11778 NN denotes binding
T5384 11779-11785 NN denotes buffer
T5385 11785-11786 -COMMA- denotes ,
T5386 11787-11789 CD denotes 50
T5387 11790-11792 NN denotes mM
T5388 11793-11796 NN denotes KCl
T5389 11796-11797 -COMMA- denotes ,
T5390 11798-11799 CD denotes 1
T5391 11800-11802 NN denotes mM
T5392 11803-11807 NN denotes EDTA
T5393 11807-11808 -COMMA- denotes ,
T5394 11809-11810 CD denotes 1
T5395 11811-11813 NN denotes mM
T5396 11814-11817 NN denotes DTT
T5397 11817-11818 -COMMA- denotes ,
T5398 11819-11822 CD denotes 0.1
T5399 11822-11823 NN denotes %
T5400 11824-11828 NN denotes NP40
T5401 11828-11829 -COMMA- denotes ,
T5402 11830-11832 CD denotes 10
T5403 11832-11833 NN denotes %
T5404 11834-11842 NN denotes glycerol
T5405 11842-11843 -COMMA- denotes ,
T5406 11844-11847 CC denotes and
T5407 11848-11850 CD denotes 50
T5408 11851-11856 NN denotes ng/μl
T5409 11857-11861 NN denotes poly
T5410 11862-11867 NN denotes dI-dC
T5411 11867-11868 -COMMA- denotes ,
T5412 11869-11873 NN denotes CREB
T5413 11873-11874 -COLON- denotes :
T5414 11875-11877 NN denotes 1x
T5415 11878-11885 NN denotes binding
T5416 11886-11892 NN denotes buffer
T5417 11892-11893 -COMMA- denotes ,
T5418 11894-11896 CD denotes 20
T5419 11897-11899 NN denotes mM
T5420 11900-11904 NN denotes Tris
T5421 11904-11905 -COMMA- denotes ,
T5422 11906-11908 NN denotes pH
T5423 11909-11912 CD denotes 7.5
T5424 11912-11913 -COMMA- denotes ,
T5425 11914-11916 CD denotes 50
T5426 11917-11919 NN denotes mM
T5427 11920-11923 NN denotes KCl
T5428 11923-11924 -COMMA- denotes ,
T5429 11925-11926 CD denotes 1
T5430 11927-11929 NN denotes mM
T5431 11930-11934 NN denotes EDTA
T5432 11934-11935 -COMMA- denotes ,
T5433 11936-11937 CD denotes 1
T5434 11938-11940 NN denotes mM
T5435 11941-11944 NN denotes DTT
T5436 11944-11945 -COMMA- denotes ,
T5437 11946-11950 CD denotes 0.10
T5438 11950-11951 NN denotes %
T5439 11952-11956 NN denotes NP40
T5440 11956-11957 -COMMA- denotes ,
T5441 11958-11959 CD denotes 6
T5442 11959-11960 NN denotes %
T5443 11961-11969 NN denotes glycerol
T5444 11969-11970 -COMMA- denotes ,
T5445 11971-11974 CD denotes 0.1
T5446 11975-11980 NN denotes mg/mL
T5447 11981-11984 NN denotes BSA
T5448 11985-11988 CC denotes and
T5449 11989-11991 CD denotes 50
T5450 11992-11997 NN denotes ng/μl
T5451 11998-12002 NN denotes poly
T5452 12003-12008 NN denotes dI-dC
T5453 12008-12009 -RRB- denotes )
T5454 12010-12013 CC denotes and
T5455 12014-12018 VB denotes were
T5456 12019-12023 RB denotes then
T5457 12024-12039 VB denotes electrophoresed
T5458 12040-12047 IN denotes through
T5459 12048-12049 DT denotes a
T5460 12050-12051 CD denotes 6
T5461 12051-12052 NN denotes %
T5462 12053-12056 NN denotes DNA
T5463 12057-12068 NN denotes retardation
T5464 12069-12072 NN denotes gel
T5465 12073-12075 IN denotes at
T5466 12076-12080 NN denotes 100V
T5467 12081-12084 IN denotes for
T5468 12085-12087 CD denotes 90
T5469 12088-12095 NN denotes minutes
T5470 12097-12100 DT denotes The
T5471 12101-12105 NN denotes gels
T5472 12106-12110 VB denotes were
T5473 12111-12130 RB denotes electrophoretically
T5474 12131-12142 VB denotes transferred
T5475 12143-12145 IN denotes at
T5476 12146-12151 NN denotes 380mA
T5477 12152-12155 IN denotes for
T5478 12156-12157 CD denotes 1
T5479 12158-12162 NN denotes hour
T5480 12163-12165 IN denotes on
T5481 12166-12169 NN denotes ice
T5482 12170-12172 TO denotes to
T5483 12173-12174 DT denotes a
T5484 12175-12185 RB denotes positively
T5485 12186-12193 VB denotes charged
T5486 12194-12199 NN denotes nylon
T5487 12200-12208 NN denotes membrane
T5488 12209-12212 CC denotes and
T5489 12213-12224 RB denotes immediately
T5490 12225-12237 JJ denotes cross-linked
T5491 12238-12241 IN denotes for
T5492 12242-12244 CD denotes 15
T5493 12245-12252 NN denotes minutes
T5494 12253-12257 IN denotes with
T5495 12258-12259 DT denotes a
T5496 12260-12262 NN denotes UV
T5497 12263-12279 NN denotes transilluminator
T5498 12280-12288 VB denotes equipped
T5499 12289-12293 IN denotes with
T5500 12294-12295 DT denotes a
T5501 12296-12299 CD denotes 312
T5502 12300-12302 NN denotes nm
T5503 12303-12307 NN denotes bulb
T5504 12309-12333 JJ denotes Streptavidin-horseradish
T5505 12334-12344 NN denotes peroxidase
T5506 12345-12354 NN denotes conjugate
T5507 12355-12358 CC denotes and
T5508 12359-12362 DT denotes the
T5509 12363-12373 NNP denotes LightShift
T5510 12374-12390 NNP denotes Chemiluminescent
T5511 12391-12400 NNP denotes Substrate
T5512 12401-12405 VB denotes were
T5513 12406-12410 VB denotes used
T5514 12411-12413 TO denotes to
T5515 12414-12420 VB denotes detect
T5516 12421-12424 DT denotes the
T5517 12425-12431 NN denotes biotin
T5518 12432-12443 JJ denotes end-labeled
T5519 12444-12447 NN denotes DNA
T5520 12449-12452 DT denotes The
T5521 12453-12458 NN denotes nylon
T5522 12459-12468 NN denotes membranes
T5523 12469-12473 VB denotes were
T5524 12474-12481 VB denotes exposed
T5525 12482-12484 TO denotes to
T5526 12485-12490 NN denotes x-ray
T5527 12491-12495 NN denotes film
T5528 12496-12499 IN denotes for
T5529 12500-12503 CD denotes 1–3
T5530 12504-12511 NN denotes minutes
T5531 12512-12515 IN denotes for
T5532 12516-12525 NN denotes detection
T5799 12528-12532 NN denotes Role
T5800 12533-12535 IN denotes of
T5801 12536-12539 NN denotes PKA
T5802 12540-12542 IN denotes on
T5803 12543-12554 JJ denotes LPS-induced
T5804 12555-12566 JJ denotes mononuclear
T5805 12567-12571 NN denotes cell
T5806 12572-12577 NN denotes TNF-α
T5807 12578-12588 NN denotes production
T5808 12589-12591 TO denotes To
T5809 12592-12600 VB denotes evaluate
T5810 12601-12604 DT denotes the
T5811 12605-12609 NN denotes role
T5812 12610-12612 IN denotes of
T5813 12613-12616 NN denotes PKA
T5814 12617-12619 IN denotes on
T5815 12620-12625 NN denotes TNF-α
T5816 12626-12636 NN denotes production
T5817 12637-12639 IN denotes in
T5818 12640-12651 JJ denotes mononuclear
T5819 12652-12657 NN denotes cells
T5820 12658-12661 CC denotes and
T5821 12662-12665 PRP-DOLLAR- denotes its
T5822 12666-12677 NN denotes involvement
T5823 12678-12680 IN denotes in
T5824 12681-12684 DT denotes the
T5825 12685-12696 NN denotes attenuation
T5826 12697-12699 IN denotes of
T5827 12700-12711 JJ denotes LPS-induced
T5828 12712-12717 NN denotes TNF-α
T5829 12718-12728 NN denotes production
T5830 12729-12737 VB denotes observed
T5831 12738-12747 VB denotes following
T5832 12748-12751 NN denotes PTX
T5833 12752-12761 NN denotes treatment
T5834 12761-12762 -COMMA- denotes ,
T5835 12763-12766 NN denotes H89
T5836 12766-12767 -COMMA- denotes ,
T5837 12768-12769 DT denotes a
T5838 12770-12778 JJ denotes specific
T5839 12779-12782 NN denotes PKA
T5840 12783-12792 NN denotes inhibitor
T5841 12792-12793 -COMMA- denotes ,
T5842 12794-12797 VB denotes was
T5843 12798-12806 VB denotes utilized
T5844 12808-12816 VB denotes Isolated
T5845 12817-12828 JJ denotes mononuclear
T5846 12829-12834 NN denotes cells
T5847 12835-12839 VB denotes were
T5848 12840-12849 VB denotes incubated
T5849 12850-12859 VB denotes according
T5850 12860-12862 TO denotes to
T5851 12863-12866 DT denotes the
T5852 12867-12876 NN denotes treatment
T5853 12877-12883 NN denotes groups
T5854 12884-12893 VB denotes described
T5855 12894-12899 RB denotes above
T5856 12900-12902 IN denotes in
T5857 12903-12906 DT denotes the
T5858 12907-12915 NN denotes presence
T5859 12916-12919 CC denotes and
T5860 12920-12927 NN denotes absence
T5861 12928-12930 IN denotes of
T5862 12931-12943 NN denotes pretreatment
T5863 12944-12948 IN denotes with
T5864 12949-12952 NN denotes H89
T5865 12953-12954 -LRB- denotes (
T5866 12954-12956 CD denotes 10
T5867 12957-12959 NN denotes μM
T5868 12959-12960 -RRB- denotes )
T5869 12961-12964 IN denotes for
T5870 12965-12966 CD denotes 1
T5871 12967-12971 NN denotes hour
T5872 12972-12974 IN denotes at
T5873 12975-12979 NN denotes 37ºC
T5874 12981-12984 DT denotes The
T5875 12985-12989 NN denotes dose
T5876 12990-12992 IN denotes of
T5877 12993-12996 NN denotes H89
T5878 12997-13000 VB denotes was
T5879 13001-13007 VB denotes chosen
T5880 13008-13013 VB denotes based
T5881 13014-13016 IN denotes on
T5882 13017-13025 JJ denotes previous
T5883 13026-13030 NN denotes work
T5884 13031-13036 WDT denotes which
T5885 13037-13049 VB denotes demonstrated
T5886 13050-13058 JJ denotes specific
T5887 13059-13062 CC denotes and
T5888 13063-13071 JJ denotes complete
T5889 13072-13082 NN denotes inhibition
T5890 13083-13085 IN denotes of
T5891 13086-13089 NN denotes PKA
T5892 13090-13092 IN denotes at
T5893 13093-13097 DT denotes this
T5894 13098-13114 NN denotes concentration.10
T5895 13115-13120 IN denotes Since
T5896 13121-13124 DT denotes the
T5897 13125-13133 NN denotes activity
T5898 13134-13136 IN denotes of
T5899 13137-13141 DT denotes this
T5900 13142-13151 NN denotes inhibitor
T5901 13152-13154 VB denotes is
T5902 13155-13159 CC denotes both
T5903 13160-13168 JJ denotes specific
T5904 13169-13172 CC denotes and
T5905 13173-13183 JJ denotes consistent
T5906 13184-13186 IN denotes at
T5907 13187-13191 DT denotes this
T5908 13192-13201 VB denotes specified
T5909 13202-13206 NN denotes dose
T5910 13206-13207 -COMMA- denotes ,
T5911 13208-13210 PRP denotes we
T5912 13211-13214 VB denotes did
T5913 13215-13218 RB denotes not
T5914 13219-13226 VB denotes include
T5915 13227-13238 NN denotes experiments
T5916 13239-13243 IN denotes with
T5917 13244-13254 JJ denotes additional
T5918 13255-13258 NN denotes PKA
T5919 13259-13269 NN denotes inhibitors
T5920 13270-13274 IN denotes with
T5921 13275-13279 DT denotes this
T5922 13280-13283 NN denotes set
T5923 13284-13286 IN denotes of
T5924 13287-13298 NN denotes experiments
T5925 13300-13303 DT denotes The
T5926 13304-13309 NN denotes TNF-α
T5927 13310-13323 NN denotes concentration
T5928 13324-13326 IN denotes in
T5929 13327-13330 DT denotes the
T5930 13331-13342 NN denotes supernatant
T5931 13343-13346 VB denotes was
T5932 13347-13355 VB denotes measured
T5933 13356-13370 RB denotes quantitatively
T5934 13371-13373 IN denotes by
T5935 13374-13379 NN denotes ELISA
T5936 13381-13384 DT denotes The
T5937 13385-13392 NN denotes results
T5938 13393-13396 VB denotes are
T5939 13397-13406 VB denotes expressed
T5940 13407-13409 IN denotes in
T5941 13410-13415 NN denotes pg/mL
T6140 13418-13429 JJ denotes Statistical
T6141 13430-13438 NN denotes Analysis
T6142 13439-13442 DT denotes The
T6143 13443-13455 JJ denotes experimental
T6144 13456-13463 NN denotes results
T6145 13464-13472 VB denotes obtained
T6146 13473-13475 IN denotes in
T6147 13476-13480 DT denotes this
T6148 13481-13486 NN denotes study
T6149 13487-13491 VB denotes were
T6150 13492-13499 VB denotes derived
T6151 13500-13504 IN denotes from
T6152 13505-13509 CD denotes four
T6153 13510-13518 JJ denotes separate
T6154 13519-13530 NN denotes experiments
T6155 13531-13535 IN denotes with
T6156 13536-13543 JJ denotes healthy
T6157 13544-13553 NN denotes volunteer
T6158 13554-13560 NN denotes donors
T6159 13562-13566 DT denotes Each
T6160 13567-13572 NN denotes assay
T6161 13573-13576 VB denotes was
T6162 13577-13586 VB denotes performed
T6163 13587-13589 IN denotes in
T6164 13590-13599 NN denotes duplicate
T6165 13600-13602 CC denotes or
T6166 13603-13613 VB denotes triplicate
T6167 13614-13619 WRB denotes where
T6168 13620-13631 JJ denotes appropriate
T6169 13633-13637 NN denotes Data
T6170 13638-13640 VB denotes is
T6171 13641-13650 VB denotes presented
T6172 13651-13653 IN denotes as
T6173 13654-13657 DT denotes the
T6174 13658-13662 JJ denotes mean
T6175 13663-13664 NN denotes ±
T6176 13665-13668 NN denotes SEM
T6177 13670-13681 JJ denotes Statistical
T6178 13682-13693 NN denotes differences
T6179 13694-13701 IN denotes between
T6180 13702-13708 NN denotes groups
T6181 13709-13713 VB denotes were
T6182 13714-13724 VB denotes determined
T6183 13725-13727 IN denotes by
T6184 13728-13735 JJ denotes one-way
T6185 13736-13744 NN denotes analysis
T6186 13745-13747 IN denotes of
T6187 13748-13756 NN denotes variance
T6188 13757-13758 -LRB- denotes (
T6189 13758-13763 NN denotes ANOVA
T6190 13763-13764 -RRB- denotes )
T6191 13765-13769 IN denotes with
T6192 13770-13771 DT denotes a
T6193 13772-13782 NNP denotes Bonferroni
T6194 13783-13793 NN denotes correction
T6195 13795-13806 JJ denotes Statistical
T6196 13807-13819 NN denotes significance
T6197 13820-13823 VB denotes was
T6198 13824-13831 VB denotes defined
T6199 13832-13834 IN denotes as
T6200 13835-13836 NN denotes P
T6201 13837-13838 SYM denotes <
T6202 13839-13843 CD denotes 0.05
T6293 13855-13858 DT denotes The
T6294 13859-13866 NN denotes effects
T6295 13867-13869 IN denotes of
T6296 13870-13873 NN denotes PTX
T6297 13874-13876 IN denotes on
T6298 13877-13888 JJ denotes LPS-induced
T6299 13889-13894 NN denotes TNF-α
T6300 13895-13905 NN denotes production
T6301 13906-13908 TO denotes To
T6302 13909-13918 VB denotes determine
T6303 13919-13922 DT denotes the
T6304 13923-13931 NN denotes duration
T6305 13932-13934 IN denotes of
T6306 13935-13938 NN denotes PDE
T6307 13939-13949 NN denotes inhibition
T6308 13950-13952 IN denotes on
T6309 13953-13958 NN denotes TNF-α
T6310 13959-13969 NN denotes production
T6311 13970-13975 IN denotes after
T6312 13976-13979 NN denotes LPS
T6313 13980-13991 NN denotes stimulation
T6314 13991-13992 -COMMA- denotes ,
T6315 13993-13997 NN denotes time
T6316 13998-14004 NN denotes course
T6317 14005-14012 NN denotes studies
T6318 14013-14017 VB denotes were
T6319 14018-14027 VB denotes conducted
T6320 14029-14031 IN denotes In
T6321 14032-14042 NN denotes accordance
T6322 14043-14047 IN denotes with
T6323 14048-14053 JJ denotes prior
T6324 14054-14058 NN denotes work
T6325 14058-14059 -COMMA- denotes ,
T6326 14060-14063 NN denotes PTX
T6327 14064-14067 VB denotes had
T6328 14068-14069 DT denotes a
T6329 14070-14075 JJ denotes rapid
T6330 14076-14079 CC denotes and
T6331 14080-14089 JJ denotes sustained
T6332 14090-14096 NN denotes effect
T6333 14097-14099 IN denotes on
T6334 14100-14105 NN denotes TNF-α
T6335 14106-14116 NN denotes production
T6336 14117-14119 FW denotes in
T6337 14120-14125 FW denotes vitro
T6338 14126-14127 -LRB- denotes (
T6339 14127-14133 NN denotes Figure
T6340 14134-14135 CD denotes 1
T6341 14135-14136 -RRB- denotes )
T6696 14139-14142 NN denotes PTX
T6697 14143-14152 VB denotes decreases
T6698 14153-14164 JJ denotes LPS-induced
T6699 14165-14170 NN denotes NF-κB
T6700 14171-14181 NN denotes activation
T6701 14182-14187 IN denotes Since
T6702 14188-14203 NN denotes phosphorylation
T6703 14204-14209 VB denotes leads
T6704 14210-14212 TO denotes to
T6705 14213-14227 NN denotes ubiquitination
T6706 14228-14231 CC denotes and
T6707 14232-14243 NN denotes degradation
T6708 14244-14246 IN denotes of
T6709 14247-14252 JJ denotes I-κBα
T6710 14253-14256 CC denotes and
T6711 14257-14267 JJ denotes subsequent
T6712 14268-14275 JJ denotes nuclear
T6713 14276-14289 NN denotes translocation
T6714 14290-14292 IN denotes of
T6715 14293-14298 NN denotes NF-κB
T6716 14298-14299 -COMMA- denotes ,
T6717 14300-14302 PRP denotes we
T6718 14303-14308 RB denotes first
T6719 14309-14317 VB denotes examined
T6720 14318-14321 DT denotes the
T6721 14322-14329 NN denotes effects
T6722 14330-14332 IN denotes of
T6723 14333-14336 NN denotes PTX
T6724 14337-14339 IN denotes on
T6725 14340-14345 NN denotes I-κBα
T6726 14347-14358 JJ denotes Cytoplasmic
T6727 14359-14364 JJ denotes I-κBα
T6728 14365-14380 NN denotes phosphorylation
T6729 14381-14384 VB denotes was
T6730 14385-14393 RB denotes markedly
T6731 14394-14403 VB denotes increased
T6732 14404-14413 VB denotes following
T6733 14414-14417 NN denotes LPS
T6734 14418-14429 NN denotes stimulation
T6735 14430-14434 WRB denotes when
T6736 14435-14443 VB denotes compared
T6737 14444-14446 TO denotes to
T6738 14447-14454 NN denotes control
T6739 14455-14456 -LRB- denotes (
T6740 14456-14459 CD denotes 100
T6741 14460-14461 SYM denotes ±
T6742 14462-14463 CD denotes 0
T6743 14464-14467 IN denotes vs.
T6744 14468-14470 CD denotes 20
T6745 14471-14472 CC denotes ±
T6746 14473-14475 CD denotes 18
T6747 14475-14476 -COLON- denotes ;
T6748 14477-14478 NN denotes P
T6749 14479-14480 SYM denotes <
T6750 14481-14485 CD denotes 0.05
T6751 14485-14486 -RRB- denotes )
T6752 14488-14491 DT denotes The
T6753 14492-14500 NN denotes addition
T6754 14501-14503 IN denotes of
T6755 14504-14507 NN denotes PTX
T6756 14508-14521 RB denotes significantly
T6757 14522-14535 VB denotes downregulated
T6758 14536-14547 JJ denotes LPS-induced
T6759 14548-14553 NN denotes I-κBα
T6760 14554-14569 NN denotes phosphorylation
T6761 14570-14571 -LRB- denotes (
T6762 14571-14572 NN denotes P
T6763 14573-14574 SYM denotes =
T6764 14575-14579 CD denotes 0.02
T6765 14579-14580 -COLON- denotes ;
T6766 14581-14587 NN denotes Figure
T6767 14588-14589 CD denotes 2
T6768 14589-14590 -RRB- denotes )
T6769 14591-14593 IN denotes In
T6770 14594-14595 DT denotes a
T6771 14596-14603 JJ denotes similar
T6772 14604-14611 NN denotes fashion
T6773 14611-14612 -COMMA- denotes ,
T6774 14613-14620 JJ denotes nuclear
T6775 14621-14626 NN denotes NF-κB
T6776 14627-14630 NN denotes p65
T6777 14631-14646 NN denotes phosphorylation
T6778 14647-14650 VB denotes was
T6779 14651-14660 VB denotes increased
T6780 14661-14670 VB denotes following
T6781 14671-14674 NN denotes LPS
T6782 14675-14686 NN denotes stimulation
T6783 14687-14688 -LRB- denotes (
T6784 14688-14691 CD denotes 100
T6785 14692-14693 SYM denotes ±
T6786 14694-14695 CD denotes 0
T6787 14696-14699 IN denotes vs.
T6788 14700-14702 CD denotes 38
T6789 14703-14704 CC denotes ±
T6790 14705-14707 CD denotes 20
T6791 14707-14708 -COLON- denotes ;
T6792 14709-14710 NN denotes P
T6793 14711-14712 SYM denotes <
T6794 14713-14717 CD denotes 0.01
T6795 14717-14718 -RRB- denotes )
T6796 14720-14723 NN denotes PTX
T6797 14724-14733 RB denotes similarly
T6798 14734-14743 VB denotes decreased
T6799 14744-14755 JJ denotes LPS-induced
T6800 14756-14761 NN denotes NF-κB
T6801 14762-14765 NN denotes p65
T6802 14766-14773 JJ denotes nuclear
T6803 14774-14789 NN denotes phosphorylation
T6804 14789-14790 -COMMA- denotes ,
T6805 14791-14792 DT denotes a
T6806 14793-14799 NN denotes marker
T6807 14800-14802 IN denotes of
T6808 14803-14808 NN denotes NF-κB
T6809 14809-14819 NN denotes activation
T6810 14820-14823 CC denotes and
T6811 14824-14831 JJ denotes nuclear
T6812 14832-14845 NN denotes translocation
T6813 14846-14847 -LRB- denotes (
T6814 14847-14850 CD denotes 100
T6815 14851-14852 SYM denotes ±
T6816 14853-14854 CD denotes 0
T6817 14855-14858 IN denotes vs.
T6818 14859-14861 CD denotes 40
T6819 14862-14863 CC denotes ±
T6820 14864-14865 CD denotes 6
T6821 14865-14866 -COLON- denotes ;
T6822 14867-14868 NN denotes P
T6823 14869-14874 CD denotes =0.03
T6824 14874-14875 -COLON- denotes ;
T6825 14876-14882 NN denotes Figure
T6826 14883-14885 NN denotes 3A
T6827 14885-14886 -RRB- denotes )
T6828 14888-14893 NN denotes EMSAs
T6829 14894-14898 VB denotes were
T6830 14899-14903 RB denotes then
T6831 14904-14913 VB denotes performed
T6832 14914-14916 TO denotes to
T6833 14917-14923 VB denotes verify
T6834 14924-14927 DT denotes the
T6835 14928-14939 JJ denotes PTX-induced
T6836 14940-14951 NN denotes alterations
T6837 14952-14954 IN denotes in
T6838 14955-14962 JJ denotes nuclear
T6839 14963-14978 NN denotes phosphorylation
T6840 14979-14987 VB denotes resulted
T6841 14988-14990 IN denotes in
T6842 14991-14998 JJ denotes similar
T6843 14999-15006 NN denotes effects
T6844 15007-15009 IN denotes on
T6845 15010-15013 DT denotes the
T6846 15014-15017 NN denotes DNA
T6847 15018-15025 NN denotes binding
T6848 15026-15034 NN denotes activity
T6849 15035-15037 IN denotes of
T6850 15038-15043 NN denotes NF-κB
T6851 15045-15048 DT denotes The
T6852 15049-15057 NN denotes addition
T6853 15058-15060 IN denotes of
T6854 15061-15064 NN denotes PTX
T6855 15065-15067 TO denotes to
T6856 15068-15082 JJ denotes LPS-stimulated
T6857 15083-15094 JJ denotes mononuclear
T6858 15095-15100 NN denotes cells
T6859 15101-15109 VB denotes resulted
T6860 15110-15112 IN denotes in
T6861 15113-15123 JJ denotes comparable
T6862 15124-15138 NN denotes downregulation
T6863 15139-15141 IN denotes of
T6864 15142-15145 NN denotes DNA
T6865 15146-15153 NN denotes binding
T6866 15154-15162 NN denotes activity
T6867 15162-15163 -COMMA- denotes ,
T6868 15164-15171 JJ denotes similar
T6869 15172-15174 TO denotes to
T6870 15175-15178 DT denotes the
T6871 15179-15187 VB denotes observed
T6872 15188-15202 NN denotes downregulation
T6873 15203-15205 IN denotes of
T6874 15206-15211 NN denotes NF-κB
T6875 15212-15227 NN denotes phosphorylation
T6876 15228-15229 -LRB- denotes (
T6877 15229-15235 NN denotes Figure
T6878 15236-15238 NN denotes 3B
T6879 15238-15239 -RRB- denotes )
T7258 15242-15245 NN denotes PTX
T7259 15246-15257 VB denotes upregulates
T7260 15258-15262 NN denotes CREB
T7261 15263-15278 NN denotes phosphorylation
T7262 15279-15282 CC denotes and
T7263 15283-15293 NN denotes activation
T7264 15294-15299 IN denotes after
T7265 15300-15303 NN denotes LPS
T7266 15304-15315 NN denotes stimulation
T7267 15316-15331 NN denotes Phosphorylation
T7268 15332-15334 IN denotes of
T7269 15335-15342 JJ denotes nuclear
T7270 15343-15347 NN denotes CREB
T7271 15348-15351 VB denotes was
T7272 15352-15356 VB denotes used
T7273 15357-15359 IN denotes as
T7274 15360-15361 DT denotes a
T7275 15362-15368 NN denotes marker
T7276 15369-15372 IN denotes for
T7277 15373-15377 NN denotes CREB
T7278 15378-15388 NN denotes activation
T7279 15390-15393 NN denotes LPS
T7280 15394-15405 NN denotes stimulation
T7281 15406-15412 VB denotes caused
T7282 15413-15414 DT denotes a
T7283 15415-15425 JJ denotes negligible
T7284 15426-15434 NN denotes increase
T7285 15435-15437 IN denotes in
T7286 15438-15442 NN denotes CREB
T7287 15443-15458 NN denotes phosphorylation
T7288 15459-15463 WRB denotes when
T7289 15464-15472 VB denotes compared
T7290 15473-15475 TO denotes to
T7291 15476-15483 NN denotes control
T7292 15484-15485 -LRB- denotes (
T7293 15485-15491 NN denotes Figure
T7294 15492-15494 NN denotes 4A
T7295 15494-15495 -RRB- denotes )
T7296 15497-15500 NN denotes PTX
T7297 15501-15506 RB denotes alone
T7298 15507-15513 VB denotes caused
T7299 15514-15515 DT denotes a
T7300 15516-15522 JJ denotes marked
T7301 15523-15531 NN denotes increase
T7302 15532-15534 IN denotes in
T7303 15535-15539 NN denotes CREB
T7304 15540-15555 NN denotes phosphorylation
T7305 15556-15557 -LRB- denotes (
T7306 15557-15558 NN denotes P
T7307 15559-15560 JJ denotes <
T7308 15561-15565 CD denotes 0.01
T7309 15566-15569 CC denotes vs.
T7310 15570-15574 NN denotes HBSS
T7311 15574-15575 -RRB- denotes )
T7312 15577-15581 WRB denotes When
T7313 15582-15585 NN denotes LPS
T7314 15586-15589 CC denotes and
T7315 15590-15593 NN denotes PTX
T7316 15594-15602 NN denotes exposure
T7317 15603-15611 VB denotes occurred
T7318 15612-15626 RB denotes simultaneously
T7319 15626-15627 -COMMA- denotes ,
T7320 15628-15632 NN denotes CREB
T7321 15633-15648 NN denotes phosphorylation
T7322 15649-15652 VB denotes was
T7323 15653-15666 RB denotes significantly
T7324 15667-15673 JJ denotes higher
T7325 15674-15678 IN denotes than
T7326 15679-15683 IN denotes with
T7327 15684-15687 NN denotes LPS
T7328 15688-15699 NN denotes stimulation
T7329 15700-15705 RB denotes alone
T7330 15706-15707 -LRB- denotes (
T7331 15707-15710 CD denotes 543
T7332 15711-15712 CC denotes ±
T7333 15713-15715 CD denotes 92
T7334 15716-15719 IN denotes vs.
T7335 15720-15723 CD denotes 100
T7336 15724-15725 SYM denotes ±
T7337 15726-15727 CD denotes 0
T7338 15727-15728 -COLON- denotes ;
T7339 15729-15730 NN denotes P
T7340 15731-15732 SYM denotes <
T7341 15733-15737 CD denotes 0.01
T7342 15737-15738 -RRB- denotes )
T7343 15740-15742 IN denotes In
T7344 15743-15751 NN denotes addition
T7345 15751-15752 -COMMA- denotes ,
T7346 15753-15756 DT denotes the
T7347 15757-15763 NN denotes amount
T7348 15764-15766 IN denotes of
T7349 15767-15771 NN denotes CREB
T7350 15772-15787 NN denotes phosphorylation
T7351 15788-15792 VB denotes seen
T7352 15793-15797 IN denotes with
T7353 15798-15809 JJ denotes concomitant
T7354 15810-15813 NN denotes LPS
T7355 15814-15817 CC denotes and
T7356 15818-15821 NN denotes PTX
T7357 15822-15831 NN denotes treatment
T7358 15832-15835 VB denotes was
T7359 15836-15840 JJ denotes less
T7360 15841-15845 IN denotes than
T7361 15846-15850 DT denotes that
T7362 15851-15855 VB denotes seen
T7363 15856-15860 IN denotes with
T7364 15861-15864 NN denotes PTX
T7365 15865-15870 RB denotes alone
T7366 15870-15871 -COMMA- denotes ,
T7367 15872-15880 IN denotes although
T7368 15881-15885 DT denotes this
T7369 15886-15896 NN denotes difference
T7370 15897-15900 VB denotes was
T7371 15901-15904 RB denotes not
T7372 15905-15918 RB denotes statistically
T7373 15919-15930 JJ denotes significant
T7374 15931-15932 -LRB- denotes (
T7375 15932-15933 NN denotes P
T7376 15934-15935 SYM denotes =
T7377 15936-15940 CD denotes 0.08
T7378 15940-15941 -RRB- denotes )
T7379 15943-15945 TO denotes To
T7380 15946-15955 VB denotes determine
T7381 15956-15958 IN denotes if
T7382 15959-15967 NN denotes CREB-DNA
T7383 15968-15975 NN denotes binding
T7384 15976-15979 VB denotes was
T7385 15980-15988 VB denotes affected
T7386 15989-15991 IN denotes by
T7387 15992-15995 NN denotes PTX
T7388 15996-15998 IN denotes in
T7389 15999-16000 DT denotes a
T7390 16001-16007 NN denotes manner
T7391 16008-16015 JJ denotes similar
T7392 16016-16018 TO denotes to
T7393 16019-16023 NN denotes CREB
T7394 16024-16039 NN denotes phosphorylation
T7395 16039-16040 -COMMA- denotes ,
T7396 16041-16043 DT denotes an
T7397 16044-16048 NN denotes EMSA
T7398 16049-16052 VB denotes was
T7399 16053-16062 VB denotes performed
T7400 16064-16072 NN denotes Exposure
T7401 16073-16075 IN denotes of
T7402 16076-16090 JJ denotes LPS-stimulated
T7403 16091-16096 NN denotes cells
T7404 16097-16099 TO denotes to
T7405 16100-16103 NN denotes PTX
T7406 16104-16113 RB denotes similarly
T7407 16114-16123 VB denotes increased
T7408 16124-16128 NN denotes CREB
T7409 16129-16140 NN denotes DNA-binding
T7410 16141-16149 VB denotes compared
T7411 16150-16152 TO denotes to
T7412 16153-16156 NN denotes LPS
T7413 16157-16162 RB denotes alone
T7414 16163-16164 -LRB- denotes (
T7415 16164-16170 NN denotes Figure
T7416 16171-16173 NN denotes 4B
T7417 16173-16174 -RRB- denotes )
T7755 16177-16183 NN denotes Effect
T7756 16184-16186 IN denotes of
T7757 16187-16190 NN denotes PTX
T7758 16191-16193 IN denotes on
T7759 16194-16199 NN denotes TNF-α
T7760 16200-16210 NN denotes production
T7761 16211-16213 IN denotes in
T7762 16214-16217 DT denotes the
T7763 16218-16226 NN denotes presence
T7764 16227-16229 IN denotes of
T7765 16230-16233 NN denotes PKA
T7766 16234-16244 NN denotes inhibition
T7767 16245-16248 DT denotes The
T7768 16249-16253 NN denotes role
T7769 16254-16256 IN denotes of
T7770 16257-16260 NN denotes PKA
T7771 16261-16263 IN denotes in
T7772 16264-16275 JJ denotes PTX-induced
T7773 16276-16290 NN denotes downregulation
T7774 16291-16293 IN denotes of
T7775 16294-16299 NN denotes TNF-α
T7776 16300-16310 NN denotes production
T7777 16311-16313 IN denotes in
T7778 16314-16328 JJ denotes LPS-stimulated
T7779 16329-16340 JJ denotes mononuclear
T7780 16341-16346 NN denotes cells
T7781 16347-16350 VB denotes was
T7782 16351-16359 VB denotes assessed
T7783 16360-16362 IN denotes by
T7784 16363-16371 VB denotes treating
T7785 16372-16383 JJ denotes mononuclear
T7786 16384-16389 NN denotes cells
T7787 16390-16394 IN denotes with
T7788 16395-16398 NN denotes H89
T7789 16398-16399 -COMMA- denotes ,
T7790 16400-16401 DT denotes a
T7791 16402-16405 NN denotes PKA
T7792 16406-16415 NN denotes inhibitor
T7793 16415-16416 -COMMA- denotes ,
T7794 16417-16422 JJ denotes prior
T7795 16423-16425 TO denotes to
T7796 16426-16429 NN denotes LPS
T7797 16430-16433 CC denotes and
T7798 16434-16437 NN denotes PTX
T7799 16438-16446 NN denotes exposure
T7800 16448-16451 DT denotes The
T7801 16452-16460 NN denotes addition
T7802 16461-16464 NN denotes PTX
T7803 16465-16467 TO denotes to
T7804 16468-16482 JJ denotes LPS-stimulated
T7805 16483-16488 NN denotes cells
T7806 16489-16497 VB denotes resulted
T7807 16498-16500 IN denotes in
T7808 16501-16502 DT denotes a
T7809 16503-16512 NN denotes reduction
T7810 16513-16515 IN denotes in
T7811 16516-16521 NN denotes TNF-α
T7812 16521-16522 -COMMA- denotes ,
T7813 16523-16530 JJ denotes similar
T7814 16531-16533 TO denotes to
T7815 16534-16538 DT denotes that
T7816 16539-16547 VB denotes observed
T7817 16548-16550 IN denotes in
T7818 16551-16554 PRP-DOLLAR- denotes our
T7819 16555-16563 JJ denotes previous
T7820 16564-16575 NN denotes experiments
T7821 16576-16577 -LRB- denotes (
T7822 16577-16580 CD denotes 529
T7823 16581-16586 NN denotes pg/mL
T7824 16587-16588 IN denotes ±
T7825 16589-16592 CD denotes 112
T7826 16593-16596 IN denotes vs.
T7827 16597-16599 CD denotes 37
T7828 16600-16605 NN denotes pg/mL
T7829 16606-16607 NN denotes ±
T7830 16608-16610 CD denotes 10
T7831 16610-16611 -COLON- denotes ;
T7832 16612-16613 NN denotes P
T7833 16614-16615 SYM denotes <
T7834 16616-16620 CD denotes 0.01
T7835 16620-16621 -RRB- denotes )
T7836 16623-16637 NN denotes Pre-incubation
T7837 16638-16640 IN denotes of
T7838 16641-16646 NN denotes cells
T7839 16647-16651 IN denotes with
T7840 16652-16655 NN denotes H89
T7841 16656-16661 JJ denotes prior
T7842 16662-16664 TO denotes to
T7843 16665-16668 NN denotes LPS
T7844 16669-16672 CC denotes and
T7845 16673-16676 NN denotes PTX
T7846 16677-16685 NN denotes exposure
T7847 16686-16689 VB denotes did
T7848 16690-16693 RB denotes not
T7849 16694-16700 VB denotes result
T7850 16701-16703 IN denotes in
T7851 16704-16707 DT denotes any
T7852 16708-16719 JJ denotes significant
T7853 16720-16730 NN denotes modulation
T7854 16731-16733 IN denotes of
T7855 16734-16739 NN denotes TNF-α
T7856 16740-16750 NN denotes production
T7857 16751-16755 WRB denotes when
T7858 16756-16764 VB denotes compared
T7859 16765-16767 TO denotes to
T7860 16768-16772 DT denotes that
T7861 16773-16785 VB denotes demonstrated
T7862 16786-16790 IN denotes with
T7863 16791-16794 NN denotes PTX
T7864 16795-16800 RB denotes alone
T7865 16801-16802 -LRB- denotes (
T7866 16802-16803 NN denotes P
T7867 16804-16805 SYM denotes =
T7868 16806-16809 CD denotes 0.2
T7869 16809-16810 -COLON- denotes ;
T7870 16811-16817 NN denotes Figure
T7871 16818-16819 CD denotes 5
T7872 16819-16820 -RRB- denotes )
T7873 16822-16827 DT denotes These
T7874 16828-16835 NN denotes results
T7875 16836-16843 VB denotes suggest
T7876 16844-16848 IN denotes that
T7877 16849-16863 NN denotes downregulation
T7878 16864-16866 IN denotes of
T7879 16867-16872 NN denotes TNF-α
T7880 16873-16883 NN denotes production
T7881 16884-16886 IN denotes by
T7882 16887-16890 NN denotes PTX
T7883 16891-16893 IN denotes in
T7884 16894-16908 JJ denotes LPS-stimulated
T7885 16909-16920 JJ denotes mononuclear
T7886 16921-16926 NN denotes cells
T7887 16927-16929 VB denotes is
T7888 16929-16930 -COMMA- denotes ,
T7889 16931-16933 IN denotes at
T7890 16934-16939 JJ denotes least
T7891 16940-16942 IN denotes in
T7892 16943-16947 NN denotes part
T7893 16947-16948 -COMMA- denotes ,
T7894 16949-16964 JJ denotes PKA-independent
R1298 T1616 T1612 arg1Of lipopolysaccharide,The
R1299 T1616 T1613 arg1Of lipopolysaccharide,bacterial
R1300 T1616 T1614 arg1Of lipopolysaccharide,membrane
R1301 T1616 T1615 arg1Of lipopolysaccharide,component
R1302 T1616 T1617 arg1Of lipopolysaccharide,(
R1303 T1616 T1620 arg1Of lipopolysaccharide,is
R1304 T1616 T1621 arg1Of lipopolysaccharide,capable
R1305 T1616 T1623 arg1Of lipopolysaccharide,initiating
R1306 T1618 T1617 arg2Of LPS,(
R1307 T1619 T1617 arg3Of ),(
R1308 T1621 T1620 arg2Of capable,is
R1309 T1621 T1622 arg1Of capable,of
R1310 T1623 T1622 arg2Of initiating,of
R1311 T1624 T1625 arg1Of phosphorylation,and
R1312 T1625 T1623 arg2Of and,initiating
R1313 T1625 T1627 arg1Of and,of
R1314 T1626 T1625 arg2Of activation,and
R1315 T1632 T1628 arg1Of kinases,multiple
R1316 T1632 T1629 arg1Of kinases,host
R1317 T1632 T1630 arg1Of kinases,intracellular
R1318 T1632 T1631 arg1Of kinases,protein
R1319 T1632 T1633 arg1Of kinases,and
R1320 T1633 T1627 arg2Of and,of
R1321 T1635 T1633 arg2Of factors,and
R1322 T1635 T1634 arg1Of factors,transcription
R1323 T1638 T1636 arg1Of activation,Transcription
R1324 T1638 T1637 arg1Of activation,factor
R1325 T1638 T1639 arg1Of activation,","
R1326 T1638 T1640 arg1Of activation,which
R1327 T1638 T1641 arg1Of activation,results
R1328 T1638 T1652 arg1Of activation,is
R1329 T1641 T1642 arg1Of results,in
R1330 T1644 T1642 arg2Of modulation,in
R1331 T1644 T1643 arg1Of modulation,the
R1332 T1644 T1645 arg1Of modulation,of
R1333 T1647 T1646 arg1Of transcription,gene
R1334 T1647 T1648 arg1Of transcription,and
R1335 T1648 T1645 arg2Of and,of
R1336 T1650 T1648 arg2Of synthesis,and
R1337 T1650 T1649 arg1Of synthesis,protein
R1338 T1652 T1651 arg1Of is,","
R1339 T1655 T1652 arg2Of element,is
R1340 T1655 T1653 arg1Of element,a
R1341 T1655 T1654 arg1Of element,critical
R1342 T1655 T1656 arg1Of element,in
R1343 T1659 T1656 arg2Of mechanism,in
R1344 T1659 T1657 arg1Of mechanism,the
R1345 T1659 T1658 arg1Of mechanism,defense
R1346 T1659 T1660 arg1Of mechanism,of
R1347 T1664 T1660 arg2Of "system.1,2",of
R1348 T1664 T1661 arg1Of "system.1,2",the
R1349 T1664 T1662 arg1Of "system.1,2",host
R1350 T1664 T1663 arg1Of "system.1,2",immune
R1351 T1668 T1665 arg1Of activation,LPS-induced
R1352 T1668 T1666 arg1Of activation,transcription
R1353 T1668 T1667 arg1Of activation,factor
R1354 T1668 T1669 arg1Of activation,has
R1355 T1668 T1670 arg1Of activation,been
R1356 T1668 T1671 arg2Of activation,shown
R1357 T1668 T1673 arg1Of activation,be
R1358 T1671 T1669 arg2Of shown,has
R1359 T1671 T1670 arg2Of shown,been
R1360 T1673 T1671 arg3Of be,shown
R1361 T1673 T1672 arg1Of be,to
R1362 T1676 T1673 arg2Of regulator,be
R1363 T1676 T1674 arg1Of regulator,a
R1364 T1676 T1675 arg1Of regulator,key
R1365 T1676 T1677 arg1Of regulator,of
R1366 T1676 T1686 modOf regulator,is
R1367 T1680 T1677 arg2Of factor-α,of
R1368 T1680 T1678 arg1Of factor-α,tumor
R1369 T1680 T1679 arg1Of factor-α,necrosis
R1370 T1682 T1681 arg2Of TNF-α,(
R1371 T1683 T1681 arg3Of ),(
R1372 T1685 T1681 arg1Of TNF-α,(
R1373 T1685 T1684 arg1Of TNF-α,production.3
R1374 T1685 T1686 arg1Of TNF-α,is
R1375 T1690 T1686 arg2Of cytokine,is
R1376 T1690 T1687 arg1Of cytokine,a
R1377 T1690 T1688 arg1Of cytokine,potent
R1378 T1690 T1689 arg1Of cytokine,pro-inflammatory
R1379 T1690 T1691 arg2Of cytokine,involved
R1380 T1691 T1692 arg1Of involved,in
R1381 T1695 T1692 arg2Of spectrum,in
R1382 T1695 T1693 arg1Of spectrum,a
R1383 T1695 T1694 arg1Of spectrum,wide
R1384 T1695 T1696 arg1Of spectrum,of
R1385 T1698 T1696 arg2Of responses,of
R1386 T1698 T1697 arg1Of responses,cellular
R1387 T1702 T1701 arg1Of synthesis,TNF-α
R1388 T1702 T1703 arg1Of synthesis,can
R1389 T1702 T1704 arg1Of synthesis,be
R1390 T1702 T1705 arg2Of synthesis,attenuated
R1391 T1705 T1703 arg2Of attenuated,can
R1392 T1705 T1704 arg2Of attenuated,be
R1393 T1705 T1706 arg1Of attenuated,in
R1394 T1705 T1716 arg1Of attenuated,after
R1395 T1708 T1706 arg2Of cells,in
R1396 T1708 T1707 arg1Of cells,immune
R1397 T1708 T1709 arg2Of cells,exposed
R1398 T1709 T1710 arg1Of exposed,to
R1399 T1711 T1712 arg1Of phosphodiesterase,(
R1400 T1713 T1712 arg2Of PDE,(
R1401 T1714 T1712 arg3Of ),(
R1402 T1715 T1710 arg2Of inhibition,to
R1403 T1715 T1711 arg1Of inhibition,phosphodiesterase
R1404 T1717 T1716 arg2Of challenge,after
R1405 T1717 T1718 arg1Of challenge,by
R1406 T1720 T1718 arg2Of variety,by
R1407 T1720 T1719 arg1Of variety,a
R1408 T1720 T1721 arg1Of variety,of
R1409 T1723 T1721 arg2Of stimulants.4,of
R1410 T1723 T1722 arg1Of stimulants.4,pro-inflammatory
R1411 T1726 T1724 arg1Of mechanisms,The
R1412 T1726 T1725 arg1Of mechanisms,signaling
R1413 T1726 T1727 arg2Of mechanisms,affected
R1414 T1726 T1731 arg1Of mechanisms,","
R1415 T1726 T1732 arg1Of mechanisms,which
R1416 T1726 T1734 arg1Of mechanisms,lead
R1417 T1726 T1742 arg1Of mechanisms,have
R1418 T1726 T1744 arg1Of mechanisms,been
R1419 T1726 T1746 arg2Of mechanisms,characterized
R1420 T1730 T1727 arg1Of inhibition,affected
R1421 T1730 T1728 arg2Of inhibition,by
R1422 T1730 T1729 arg1Of inhibition,PDE
R1423 T1734 T1733 arg1Of lead,ultimately
R1424 T1734 T1735 arg1Of lead,to
R1425 T1737 T1735 arg2Of downregulation,to
R1426 T1737 T1736 arg1Of downregulation,the
R1427 T1737 T1738 arg1Of downregulation,of
R1428 T1740 T1738 arg2Of production,of
R1429 T1740 T1739 arg1Of production,TNF-α
R1430 T1746 T1699 arg1Of characterized,Furthermore
R1431 T1746 T1700 arg1Of characterized,","
R1432 T1746 T1703 modOf characterized,can
R1433 T1746 T1741 arg1Of characterized,","
R1434 T1746 T1742 arg2Of characterized,have
R1435 T1746 T1743 arg1Of characterized,not
R1436 T1746 T1744 arg2Of characterized,been
R1437 T1746 T1745 arg1Of characterized,well
R1438 T1746 T1747 arg1Of characterized,in
R1439 T1749 T1747 arg2Of cells,in
R1440 T1749 T1748 arg1Of cells,inflammatory
R1441 T1752 T1753 arg1Of it,has
R1442 T1752 T1754 arg1Of it,been
R1443 T1752 T1755 arg2Of it,demonstrated
R1444 T1755 T1750 arg1Of demonstrated,Classically
R1445 T1755 T1751 arg1Of demonstrated,","
R1446 T1755 T1753 arg2Of demonstrated,has
R1447 T1755 T1754 arg2Of demonstrated,been
R1448 T1758 T1757 arg1Of inhibition,PDE
R1449 T1758 T1759 arg1Of inhibition,results
R1450 T1759 T1760 arg1Of results,in
R1451 T1759 T1773 arg1Of results,and
R1452 T1763 T1760 arg2Of accumulation,in
R1453 T1763 T1761 arg1Of accumulation,the
R1454 T1763 T1762 arg1Of accumulation,intracellular
R1455 T1763 T1764 arg1Of accumulation,of
R1456 T1769 T1764 arg2Of "adenosine-3,5-monophosphate",of
R1457 T1769 T1765 arg1Of "adenosine-3,5-monophosphate",the
R1458 T1769 T1766 arg1Of "adenosine-3,5-monophosphate",second
R1459 T1769 T1767 arg1Of "adenosine-3,5-monophosphate",messenger
R1460 T1769 T1768 arg1Of "adenosine-3,5-monophosphate",cyclic
R1461 T1769 T1770 arg1Of "adenosine-3,5-monophosphate",(
R1462 T1771 T1770 arg2Of cAMP,(
R1463 T1772 T1770 arg3Of ),(
R1464 T1773 T1810 arg1Of and,and
R1465 T1775 T1774 arg1Of activation,subsequent
R1466 T1775 T1776 arg1Of activation,of
R1467 T1775 T1787 arg1Of activation,leads
R1468 T1781 T1780 arg2Of PKA,(
R1469 T1782 T1780 arg3Of ),(
R1470 T1785 T1776 arg2Of activation,of
R1471 T1785 T1777 arg1Of activation,Protein
R1472 T1785 T1778 arg1Of activation,kinase
R1473 T1785 T1779 arg1Of activation,A
R1474 T1785 T1780 arg1Of activation,(
R1475 T1785 T1783 arg1Of activation,.5
R1476 T1785 T1784 arg1Of activation,PKA
R1477 T1787 T1773 arg2Of leads,and
R1478 T1787 T1786 arg1Of leads,then
R1479 T1787 T1788 arg1Of leads,to
R1480 T1790 T1788 arg2Of phosphorylation,to
R1481 T1790 T1789 arg1Of phosphorylation,the
R1482 T1790 T1791 arg1Of phosphorylation,of
R1483 T1798 T1793 arg1Of protein,transcription
R1484 T1798 T1794 arg1Of protein,factor
R1485 T1798 T1795 arg1Of protein,cAMP-response
R1486 T1798 T1796 arg1Of protein,element
R1487 T1798 T1797 arg1Of protein,binding
R1488 T1798 T1799 arg1Of protein,(
R1489 T1798 T1802 arg1Of protein,","
R1490 T1800 T1799 arg2Of CREB,(
R1491 T1801 T1799 arg3Of ),(
R1492 T1802 T1791 arg2Of ",",of
R1493 T1802 T1792 arg1Of ",",the
R1494 T1803 T1802 arg2Of transmission,","
R1495 T1803 T1804 arg1Of transmission,of
R1496 T1803 T1806 arg1Of transmission,into
R1497 T1805 T1804 arg2Of signals,of
R1498 T1808 T1806 arg2Of nucleus,into
R1499 T1808 T1807 arg1Of nucleus,the
R1500 T1810 T1755 arg3Of and,demonstrated
R1501 T1810 T1756 arg1Of and,that
R1502 T1810 T1809 arg1Of and,","
R1503 T1813 T1811 arg1Of modulation,the
R1504 T1813 T1812 arg1Of modulation,subsequent
R1505 T1813 T1814 arg1Of modulation,of
R1506 T1813 T1822 arg1Of modulation,does
R1507 T1813 T1825 arg1Of modulation,explain
R1508 T1816 T1815 arg1Of transcription.6,gene
R1509 T1819 T1818 arg1Of simple,apparently
R1510 T1821 T1814 arg2Of cascade,of
R1511 T1821 T1816 arg1Of cascade,transcription.6
R1512 T1821 T1817 arg1Of cascade,This
R1513 T1821 T1819 arg1Of cascade,simple
R1514 T1821 T1820 arg1Of cascade,linear
R1515 T1825 T1810 arg2Of explain,and
R1516 T1825 T1822 arg2Of explain,does
R1517 T1825 T1823 arg1Of explain,not
R1518 T1825 T1824 arg1Of explain,fully
R1519 T1827 T1825 arg2Of mechanism,explain
R1520 T1827 T1826 arg1Of mechanism,the
R1521 T1827 T1828 arg2Of mechanism,by
R1522 T1827 T1829 arg1Of mechanism,which
R1523 T1831 T1830 arg1Of elevation,an
R1524 T1831 T1832 arg1Of elevation,in
R1525 T1831 T1837 arg1Of elevation,exerts
R1526 T1836 T1832 arg2Of level,in
R1527 T1836 T1833 arg1Of level,the
R1528 T1836 T1834 arg1Of level,intracellular
R1529 T1836 T1835 arg1Of level,cAMP
R1530 T1837 T1828 arg1Of exerts,by
R1531 T1837 T1840 arg1Of exerts,on
R1532 T1839 T1837 arg2Of effects,exerts
R1533 T1839 T1838 arg1Of effects,wide-ranging
R1534 T1843 T1840 arg2Of functions,on
R1535 T1843 T1841 arg1Of functions,multiple
R1536 T1843 T1842 arg1Of functions,cellular
R1537 T1844 T1845 arg1Of There,is
R1538 T1848 T1845 arg2Of body,is
R1539 T1848 T1846 arg1Of body,a
R1540 T1848 T1847 arg1Of body,growing
R1541 T1848 T1849 arg1Of body,of
R1542 T1848 T1851 arg1Of body,suggesting
R1543 T1850 T1849 arg2Of evidence,of
R1544 T1853 T1854 arg1Of cAMP,may
R1545 T1853 T1855 arg1Of cAMP,function
R1546 T1855 T1851 arg2Of function,suggesting
R1547 T1855 T1852 arg1Of function,that
R1548 T1855 T1854 arg2Of function,may
R1549 T1855 T1856 arg1Of function,through
R1550 T1858 T1859 arg1Of PKA-dependent,and
R1551 T1860 T1859 arg2Of -independent,and
R1552 T1861 T1856 arg2Of mechanisms.6–8,through
R1553 T1861 T1857 arg1Of mechanisms.6–8,both
R1554 T1861 T1858 arg1Of mechanisms.6–8,PKA-dependent
R1555 T1861 T1860 arg1Of mechanisms.6–8,-independent
R1556 T1863 T1862 arg1Of activation,LPS-induced
R1557 T1863 T1864 arg1Of activation,of
R1558 T1863 T1873 arg1Of activation,has
R1559 T1863 T1875 arg1Of activation,been
R1560 T1869 T1864 arg2Of factor-κB,of
R1561 T1869 T1865 arg1Of factor-κB,the
R1562 T1869 T1866 arg1Of factor-κB,transcription
R1563 T1869 T1867 arg1Of factor-κB,factor
R1564 T1869 T1868 arg1Of factor-κB,nuclear
R1565 T1869 T1870 arg1Of factor-κB,(
R1566 T1871 T1870 arg2Of NF-κB,(
R1567 T1872 T1870 arg3Of ),(
R1568 T1875 T1873 arg2Of been,has
R1569 T1875 T1874 arg1Of been,also
R1570 T1877 T1875 arg2Of focus,been
R1571 T1877 T1876 arg1Of focus,the
R1572 T1877 T1878 arg1Of focus,of
R1573 T1881 T1878 arg2Of deal,of
R1574 T1881 T1879 arg1Of deal,a
R1575 T1881 T1880 arg1Of deal,great
R1576 T1881 T1882 arg1Of deal,of
R1577 T1883 T1882 arg2Of research,of
R1578 T1884 T1885 arg1Of It,has
R1579 T1884 T1886 arg1Of It,been
R1580 T1884 T1888 arg2Of It,demonstrated
R1581 T1888 T1885 arg2Of demonstrated,has
R1582 T1888 T1886 arg2Of demonstrated,been
R1583 T1888 T1887 arg1Of demonstrated,clearly
R1584 T1890 T1891 arg1Of agents,that
R1585 T1890 T1892 arg1Of agents,increase
R1586 T1890 T1896 arg1Of agents,inhibit
R1587 T1894 T1892 arg2Of cAMP,increase
R1588 T1894 T1893 arg1Of cAMP,intracellular
R1589 T1896 T1888 arg3Of inhibit,demonstrated
R1590 T1896 T1889 arg1Of inhibit,that
R1591 T1896 T1895 arg1Of inhibit,also
R1592 T1900 T1896 arg2Of transcription,inhibit
R1593 T1900 T1897 arg1Of transcription,NF-κB-dependent
R1594 T1900 T1898 arg1Of transcription,pro-inflammatory
R1595 T1900 T1899 arg1Of transcription,gene
R1596 T1900 T1901 arg1Of transcription,","
R1597 T1900 T1903 arg1Of transcription,of
R1598 T1903 T1902 arg1Of of,particularly
R1599 T1906 T1903 arg2Of gene.9,of
R1600 T1906 T1904 arg1Of gene.9,the
R1601 T1906 T1905 arg1Of gene.9,TNF-α
R1602 T1907 T1908 arg1Of Controversy,exists
R1603 T1908 T1909 arg1Of exists,regarding
R1604 T1912 T1909 arg2Of mechanism,regarding
R1605 T1912 T1910 arg1Of mechanism,the
R1606 T1912 T1911 arg1Of mechanism,exact
R1607 T1912 T1913 arg1Of mechanism,(
R1608 T1912 T1916 arg2Of mechanism,by
R1609 T1912 T1917 arg1Of mechanism,which
R1610 T1914 T1913 arg2Of s,(
R1611 T1915 T1913 arg3Of ),(
R1612 T1919 T1918 arg1Of inhibition,PDE
R1613 T1919 T1920 arg1Of inhibition,down-regulates
R1614 T1920 T1916 arg1Of down-regulates,by
R1615 T1922 T1920 arg2Of production,down-regulates
R1616 T1922 T1921 arg1Of production,TNF-α
R1617 T1923 T1924 arg1Of Possibilities,include
R1618 T1923 T1927 arg1Of Possibilities,are
R1619 T1923 T1929 arg2Of Possibilities,limited
R1620 T1924 T1926 arg1Of include,but
R1621 T1926 T1925 arg1Of but,","
R1622 T1926 T1931 arg1Of but,","
R1623 T1929 T1926 arg2Of limited,but
R1624 T1929 T1927 arg2Of limited,are
R1625 T1929 T1928 arg1Of limited,not
R1626 T1929 T1930 arg1Of limited,to
R1627 T1932 T1933 arg1Of inhibition,of
R1628 T1932 T1945 arg1Of inhibition,increased
R1629 T1937 T1934 arg1Of activity,NF-κB
R1630 T1937 T1935 arg1Of activity,DNA
R1631 T1937 T1936 arg1Of activity,binding
R1632 T1937 T1938 arg1Of activity,","
R1633 T1938 T1933 arg2Of ",",of
R1634 T1939 T1938 arg2Of downregulation,","
R1635 T1939 T1940 arg1Of downregulation,of
R1636 T1943 T1940 arg2Of activity,of
R1637 T1943 T1941 arg1Of activity,NF-κB
R1638 T1943 T1942 arg1Of activity,transcriptional
R1639 T1945 T1931 arg2Of increased,","
R1640 T1945 T1944 arg1Of increased,","
R1641 T1947 T1946 arg1Of activation,CREB
R1642 T1947 T1949 arg1Of activation,and
R1643 T1949 T1945 arg2Of and,increased
R1644 T1949 T1948 arg1Of and,","
R1645 T1950 T1949 arg2Of competition,and
R1646 T1950 T1951 arg1Of competition,between
R1647 T1952 T1953 arg1Of NF-κB,and
R1648 T1953 T1951 arg2Of and,between
R1649 T1953 T1955 arg1Of and,for
R1650 T1954 T1953 arg2Of CREB,and
R1651 T1957 T1955 arg2Of co-activators,for
R1652 T1957 T1956 arg1Of co-activators,common
R1653 T1957 T1959 arg1Of co-activators,as
R1654 T1959 T1958 arg1Of as,such
R1655 T1962 T1959 arg2Of protein,as
R1656 T1962 T1960 arg1Of protein,CREB
R1657 T1962 T1961 arg1Of protein,binding
R1658 T1962 T1963 arg1Of protein,(
R1659 T1964 T1963 arg2Of CBP,(
R1660 T1965 T1963 arg3Of ),(
R1661 T1966 T1967 arg1Of It,is
R1662 T1966 T1970 arg2Of It,known
R1663 T1970 T1967 arg2Of known,is
R1664 T1970 T1968 arg1Of known,also
R1665 T1970 T1969 arg1Of known,not
R1666 T1973 T1972 arg1Of processes,these
R1667 T1973 T1974 arg1Of processes,rely
R1668 T1974 T1970 arg3Of rely,known
R1669 T1974 T1971 arg1Of rely,whether
R1670 T1974 T1975 arg1Of rely,solely
R1671 T1974 T1976 arg1Of rely,upon
R1672 T1978 T1976 arg2Of activation,upon
R1673 T1978 T1977 arg1Of activation,the
R1674 T1978 T1979 arg1Of activation,of
R1675 T1980 T1979 arg2Of PKA,of
R1676 T1984 T1983 arg1Of objective,the
R1677 T1984 T1985 arg1Of objective,of
R1678 T1984 T1989 arg1Of objective,is
R1679 T1988 T1985 arg2Of study,of
R1680 T1988 T1986 arg1Of study,the
R1681 T1988 T1987 arg1Of study,present
R1682 T1989 T1981 arg1Of is,Therefore
R1683 T1989 T1982 arg1Of is,","
R1684 T1991 T1989 arg2Of determine,is
R1685 T1991 T1990 arg1Of determine,to
R1686 T1991 T1998 arg1Of determine,with
R1687 T1991 T2015 arg1Of determine,vitro
R1688 T1991 T2016 arg1Of determine,in
R1689 T1993 T1991 arg2Of effects,determine
R1690 T1993 T1992 arg1Of effects,the
R1691 T1993 T1994 arg1Of effects,of
R1692 T1997 T1994 arg2Of inhibition,of
R1693 T1997 T1995 arg1Of inhibition,nonspecific
R1694 T1997 T1996 arg1Of inhibition,PDE
R1695 T2001 T2000 arg2Of 5-oxohexyl,[
R1696 T2002 T2000 arg3Of ],[
R1697 T2003 T1998 arg2Of "-3,7-dimethylxanthine",with
R1698 T2003 T1999 arg1Of "-3,7-dimethylxanthine",1-
R1699 T2003 T2000 arg1Of "-3,7-dimethylxanthine",[
R1700 T2003 T2004 arg1Of "-3,7-dimethylxanthine",(
R1701 T2003 T2009 arg1Of "-3,7-dimethylxanthine",on
R1702 T2005 T2004 arg2Of Pentoxifylline,(
R1703 T2005 T2006 arg1Of Pentoxifylline,;
R1704 T2007 T2006 arg2Of PTX,;
R1705 T2008 T2004 arg3Of ),(
R1706 T2010 T2011 arg1Of NF-κB,and
R1707 T2012 T2011 arg2Of CREB,and
R1708 T2013 T2009 arg2Of activation,on
R1709 T2013 T2010 arg1Of activation,NF-κB
R1710 T2013 T2012 arg1Of activation,CREB
R1711 T2015 T2014 arg1Of vitro,in
R1712 T2019 T2016 arg2Of cells,in
R1713 T2019 T2017 arg1Of cells,human
R1714 T2019 T2018 arg1Of cells,mononuclear
R1715 T2022 T2020 arg2Of use,With
R1716 T2022 T2021 arg1Of use,the
R1717 T2022 T2023 arg1Of use,of
R1718 T2025 T2023 arg2Of inhibitors,of
R1719 T2025 T2024 arg1Of inhibitors,specific
R1720 T2027 T2029 arg1Of we,investigated
R1721 T2029 T2020 arg1Of investigated,With
R1722 T2029 T2026 arg1Of investigated,","
R1723 T2029 T2028 arg1Of investigated,also
R1724 T2031 T2029 arg2Of role,investigated
R1725 T2031 T2030 arg1Of role,the
R1726 T2031 T2032 arg1Of role,of
R1727 T2031 T2034 arg1Of role,in
R1728 T2033 T2032 arg2Of PKA,of
R1729 T2037 T2034 arg2Of production,in
R1730 T2037 T2035 arg1Of production,LPS-induced
R1731 T2037 T2036 arg1Of production,TNF-α
R2218 T2792 T2791 arg1Of study,this
R2219 T2792 T2793 arg1Of study,was
R2220 T2792 T2794 arg2Of study,approved
R2221 T2794 T2793 arg2Of approved,was
R2222 T2794 T2810 arg1Of approved,in
R2223 T2800 T2796 arg1Of Program,the
R2224 T2800 T2797 arg1Of Program,Human
R2225 T2800 T2798 arg1Of Program,Research
R2226 T2800 T2799 arg1Of Program,Protections
R2227 T2800 T2801 arg1Of Program,and
R2228 T2801 T2794 arg1Of and,approved
R2229 T2801 T2795 arg2Of and,by
R2230 T2806 T2803 arg1Of Written,Institutional
R2231 T2806 T2804 arg1Of Written,Review
R2232 T2806 T2805 arg1Of Written,Board.
R2233 T2807 T2801 arg2Of consent,and
R2234 T2807 T2802 arg1Of consent,the
R2235 T2807 T2806 arg1Of consent,Written
R2236 T2807 T2808 modOf consent,to
R2237 T2809 T2808 arg1Of participate,to
R2238 T2812 T2811 arg1Of study,the
R2239 T2812 T2813 arg1Of study,was
R2240 T2812 T2814 arg2Of study,obtained
R2241 T2814 T2813 arg2Of obtained,was
R2242 T2814 T2815 arg1Of obtained,from
R2243 T2814 T2818 arg1Of obtained,prior
R2244 T2817 T2815 arg2Of volunteers,from
R2245 T2817 T2816 arg1Of volunteers,all
R2246 T2818 T2819 arg1Of prior,to
R2247 T2820 T2819 arg2Of blood,to
R2248 T2822 T2821 arg1Of Vacutainers,"donation. Heparinized"
R2249 T2822 T2823 arg1Of Vacutainers,were
R2250 T2822 T2824 arg2Of Vacutainers,purchased
R2251 T2824 T2810 arg2Of purchased,in
R2252 T2824 T2813 modOf purchased,was
R2253 T2824 T2823 arg2Of purchased,were
R2254 T2824 T2825 arg1Of purchased,from
R2255 T2827 T2825 arg2Of Dickinson,from
R2256 T2827 T2826 arg1Of Dickinson,Becton
R2257 T2827 T2828 arg1Of Dickinson,(
R2258 T2830 T2828 arg2Of Jose,(
R2259 T2830 T2829 arg1Of Jose,San
R2260 T2830 T2831 arg1Of Jose,","
R2261 T2832 T2831 arg2Of CA,","
R2262 T2833 T2828 arg3Of ),(
R2263 T2837 T2834 arg1Of tubes,1.5-mL
R2264 T2837 T2835 arg1Of tubes,Eppendorf
R2265 T2837 T2836 arg1Of tubes,centrifuge
R2266 T2837 T2838 arg1Of tubes,were
R2267 T2837 T2839 arg2Of tubes,purchased
R2268 T2839 T2838 arg2Of purchased,were
R2269 T2839 T2840 arg1Of purchased,from
R2270 T2842 T2840 arg2Of Scientific,from
R2271 T2842 T2841 arg1Of Scientific,Fisher
R2272 T2842 T2843 arg1Of Scientific,(
R2273 T2844 T2843 arg2Of Pittsburg,(
R2274 T2844 T2845 arg1Of Pittsburg,","
R2275 T2844 T2846 arg1Of Pittsburg,PA
R2276 T2847 T2843 arg3Of ),(
R2277 T2851 T2848 arg1Of solution,Hank’s
R2278 T2851 T2849 arg1Of solution,balanced
R2279 T2851 T2850 arg1Of solution,salt
R2280 T2851 T2852 arg1Of solution,(
R2281 T2851 T2855 arg1Of solution,and
R2282 T2853 T2852 arg2Of HBSS,(
R2283 T2854 T2852 arg3Of ),(
R2284 T2855 T2858 arg1Of and,were
R2285 T2855 T2859 arg2Of and,obtained
R2286 T2856 T2855 arg2Of RPMI,and
R2287 T2856 T2857 arg1Of RPMI,1640
R2288 T2859 T2858 arg2Of obtained,were
R2289 T2859 T2860 arg1Of obtained,from
R2290 T2862 T2860 arg2Of Scientific,from
R2291 T2862 T2861 arg1Of Scientific,Irvine
R2292 T2862 T2863 arg1Of Scientific,(
R2293 T2865 T2863 arg2Of Ana,(
R2294 T2865 T2864 arg1Of Ana,Santa
R2295 T2865 T2866 arg1Of Ana,","
R2296 T2867 T2866 arg2Of CA,","
R2297 T2868 T2863 arg3Of ),(
R2298 T2871 T2869 arg1Of coli serotype,LPS
R2299 T2871 T2870 arg1Of coli serotype,from Escherichia
R2300 T2871 T2872 arg1Of coli serotype,0111
R2301 T2871 T2873 arg1Of coli serotype,:
R2302 T2871 T2877 arg1Of coli serotype,were
R2303 T2871 T2878 arg2Of coli serotype,purchased
R2304 T2874 T2875 arg1Of B4,and
R2305 T2875 T2873 arg2Of and,:
R2306 T2876 T2875 arg2Of PTX,and
R2307 T2878 T2877 arg2Of purchased,were
R2308 T2878 T2879 arg1Of purchased,from
R2309 T2880 T2879 arg2Of Sigma,from
R2310 T2880 T2881 arg1Of Sigma,(
R2311 T2883 T2881 arg2Of Louis,(
R2312 T2883 T2882 arg1Of Louis,St.
R2313 T2883 T2884 arg1Of Louis,","
R2314 T2885 T2884 arg2Of MO,","
R2315 T2886 T2881 arg3Of ),(
R2316 T2889 T2887 arg1Of inhibitor,The
R2317 T2889 T2888 arg1Of inhibitor,PKA
R2318 T2889 T2890 arg1Of inhibitor,","
R2319 T2891 T2890 arg2Of N-,","
R2320 T2891 T2892 arg1Of N-,[
R2321 T2893 T2892 arg2Of 2-,[
R2322 T2893 T2894 arg1Of 2-,(
R2323 T2893 T2900 arg1Of 2-,ethyl
R2324 T2896 T2895 arg2Of p-bromocinnamyl,(
R2325 T2897 T2895 arg3Of ),(
R2326 T2898 T2894 arg2Of amino,(
R2327 T2898 T2895 arg1Of amino,(
R2328 T2899 T2894 arg3Of ),(
R2329 T2901 T2892 arg3Of ],[
R2330 T2902 T2889 arg1Of -5-isoguinolinesulfonamide-2HCl,inhibitor
R2331 T2902 T2903 arg1Of -5-isoguinolinesulfonamide-2HCl,]
R2332 T2902 T2904 arg1Of -5-isoguinolinesulfonamide-2HCl,(
R2333 T2902 T2908 arg1Of -5-isoguinolinesulfonamide-2HCl,was
R2334 T2902 T2909 arg2Of -5-isoguinolinesulfonamide-2HCl,purchased
R2335 T2905 T2904 arg2Of H89,(
R2336 T2906 T2904 arg3Of ),(
R2337 T2909 T2907 arg1Of purchased,","
R2338 T2909 T2908 arg2Of purchased,was
R2339 T2909 T2910 arg1Of purchased,from
R2340 T2911 T2910 arg2Of Calbiochem,from
R2341 T2911 T2912 arg1Of Calbiochem,(
R2342 T2914 T2912 arg2Of Jolla,(
R2343 T2914 T2913 arg1Of Jolla,La
R2344 T2914 T2915 arg1Of Jolla,","
R2345 T2916 T2915 arg2Of CA,","
R2346 T2917 T2912 arg3Of ),(
R2347 T2918 T2919 arg1Of Antibodies,for
R2348 T2918 T2945 arg1Of Antibodies,and
R2349 T2921 T2920 arg2Of CREB,phosphorylated
R2350 T2921 T2922 arg1Of CREB,(
R2351 T2921 T2926 arg1Of CREB,","
R2352 T2923 T2922 arg2Of serine,(
R2353 T2923 T2924 arg1Of serine,133
R2354 T2925 T2922 arg3Of ),(
R2355 T2926 T2935 arg1Of ",",","
R2356 T2928 T2926 arg2Of I-κBα,","
R2357 T2928 T2927 arg2Of I-κBα,phosphorylated
R2358 T2928 T2929 arg1Of I-κBα,(
R2359 T2931 T2932 arg1Of 32,and
R2360 T2932 T2929 arg2Of and,(
R2361 T2932 T2930 arg1Of and,serines
R2362 T2933 T2932 arg2Of 36,and
R2363 T2934 T2929 arg3Of ),(
R2364 T2935 T2919 arg2Of ",",for
R2365 T2939 T2935 arg2Of subunit,","
R2366 T2939 T2936 arg2Of subunit,phosphorylated
R2367 T2939 T2937 arg1Of subunit,NF-κB
R2368 T2939 T2938 arg1Of subunit,p65
R2369 T2939 T2940 arg1Of subunit,(
R2370 T2941 T2940 arg2Of serine,(
R2371 T2941 T2942 arg1Of serine,276
R2372 T2943 T2940 arg3Of ),(
R2373 T2945 T2944 arg1Of and,","
R2374 T2945 T2948 arg1Of and,were
R2375 T2945 T2949 arg2Of and,purchased
R2376 T2947 T2945 arg2Of antibodies,and
R2377 T2947 T2946 arg1Of antibodies,secondary
R2378 T2949 T2948 arg2Of purchased,were
R2379 T2949 T2950 arg1Of purchased,from
R2380 T2949 T2953 arg1Of purchased,(
R2381 T2952 T2950 arg2Of Signaling,from
R2382 T2952 T2951 arg1Of Signaling,Cell
R2383 T2954 T2953 arg2Of Beverly,(
R2384 T2954 T2955 arg1Of Beverly,","
R2385 T2954 T2956 arg1Of Beverly,MA
R2386 T2957 T2953 arg3Of ),(
R2387 T2959 T2960 arg1Of T500,and
R2388 T2960 T2958 arg1Of and,". Dextran"
R2389 T2960 T2962 arg1Of and,were
R2390 T2960 T2963 arg2Of and,received
R2391 T2961 T2960 arg2Of Percoll,and
R2392 T2963 T2948 modOf received,were
R2393 T2963 T2962 arg2Of received,were
R2394 T2963 T2964 arg1Of received,from
R2395 T2967 T2964 arg2Of Biosciences,from
R2396 T2967 T2965 arg1Of Biosciences,GE
R2397 T2967 T2966 arg1Of Biosciences,Healthcare/Amersham
R2398 T2967 T2968 arg1Of Biosciences,(
R2399 T2969 T2968 arg2Of Piscataway,(
R2400 T2969 T2970 arg1Of Piscataway,","
R2401 T2969 T2971 arg1Of Piscataway,NJ
R2402 T2972 T2968 arg3Of ),(
R2403 T2976 T2973 arg1Of assay,The
R2404 T2976 T2974 arg1Of assay,enzyme-linked
R2405 T2976 T2975 arg1Of assay,immunosorbent
R2406 T2976 T2977 arg1Of assay,(
R2407 T2976 T2980 arg1Of assay,for
R2408 T2976 T2982 arg1Of assay,was
R2409 T2976 T2983 arg2Of assay,obtained
R2410 T2978 T2977 arg2Of ELISA,(
R2411 T2979 T2977 arg3Of ),(
R2412 T2981 T2980 arg2Of TNF-α,for
R2413 T2983 T2982 arg2Of obtained,was
R2414 T2983 T2984 arg1Of obtained,from
R2415 T2983 T3004 arg1Of obtained,and
R2416 T2989 T2985 arg1Of Systems,Quantikine
R2417 T2989 T2986 arg1Of Systems,R
R2418 T2989 T2987 arg1Of Systems,&
R2419 T2989 T2988 arg1Of Systems,D
R2420 T2989 T2990 arg1Of Systems,(
R2421 T2991 T2990 arg2Of Minneapolis,(
R2422 T2991 T2992 arg1Of Minneapolis,","
R2423 T2991 T2993 arg1Of Minneapolis,MN
R2424 T2994 T2990 arg3Of ),(
R2425 T2995 T2989 arg1Of ". Tris-glycine",Systems
R2426 T2995 T2996 arg1Of ". Tris-glycine",and
R2427 T2996 T3000 arg1Of and,","
R2428 T2999 T2996 arg2Of gels,and
R2429 T2999 T2997 arg1Of gels,DNA
R2430 T2999 T2998 arg1Of gels,retardation
R2431 T3000 T2984 arg2Of ",",from
R2432 T3002 T3000 arg2Of membranes,","
R2433 T3002 T3001 arg1Of membranes,nitrocellulose
R2434 T3004 T3003 arg1Of and,","
R2435 T3008 T3005 arg1Of buffers,western
R2436 T3008 T3006 arg1Of buffers,blot
R2437 T3008 T3007 arg1Of buffers,running
R2438 T3008 T3009 arg1Of buffers,were
R2439 T3008 T3010 arg2Of buffers,obtained
R2440 T3010 T3004 arg2Of obtained,and
R2441 T3010 T3009 arg2Of obtained,were
R2442 T3010 T3011 arg1Of obtained,from
R2443 T3010 T3013 arg1Of obtained,(
R2444 T3012 T3011 arg2Of Invitrogen,from
R2445 T3014 T3013 arg2Of Carlsbad,(
R2446 T3014 T3015 arg1Of Carlsbad,","
R2447 T3014 T3016 arg1Of Carlsbad,CA
R2448 T3017 T3013 arg3Of ),(
R2449 T3018 T3019 arg1Of NE-PER® nuclear,and
R2450 T3020 T3019 arg2Of cytoplasmic,and
R2451 T3022 T3018 arg1Of reagents,NE-PER® nuclear
R2452 T3022 T3020 arg1Of reagents,cytoplasmic
R2453 T3022 T3021 arg1Of reagents,extraction
R2454 T3022 T3023 arg1Of reagents,","
R2455 T3023 T3029 arg1Of ",",","
R2456 T3023 T3037 arg1Of ",",and
R2457 T3028 T3023 arg2Of kit,","
R2458 T3028 T3024 arg1Of kit,the
R2459 T3028 T3025 arg1Of kit,BCA
R2460 T3028 T3026 arg1Of kit,protein
R2461 T3028 T3027 arg1Of kit,reagent
R2462 T3035 T3029 arg2Of Kit,","
R2463 T3035 T3030 arg1Of Kit,the
R2464 T3035 T3031 arg1Of Kit,Supersignal
R2465 T3035 T3032 arg1Of Kit,West
R2466 T3035 T3033 arg1Of Kit,Pico
R2467 T3035 T3034 arg1Of Kit,Chemiluminescent
R2468 T3037 T3036 arg1Of and,","
R2469 T3037 T3043 arg1Of and,were
R2470 T3037 T3044 arg2Of and,purchased
R2471 T3041 T3039 arg1Of EMSA,LightShift
R2472 T3041 T3040 arg1Of EMSA,Chemiluminescent
R2473 T3042 T3037 arg2Of Kit,and
R2474 T3042 T3038 arg1Of Kit,the
R2475 T3042 T3041 arg1Of Kit,EMSA
R2476 T3044 T3043 arg2Of purchased,were
R2477 T3044 T3045 arg1Of purchased,from
R2478 T3046 T3045 arg2Of Pierce,from
R2479 T3046 T3047 arg1Of Pierce,(
R2480 T3048 T3047 arg2Of Rockland,(
R2481 T3048 T3049 arg1Of Rockland,","
R2482 T3050 T3049 arg2Of IL,","
R2483 T3051 T3047 arg3Of ),(
R2484 T3052 T3053 arg1Of CREB,and
R2485 T3054 T3053 arg2Of NF-κB,and
R2486 T3057 T3052 arg1Of probes,CREB
R2487 T3057 T3054 arg1Of probes,NF-κB
R2488 T3057 T3055 arg1Of probes,DNA
R2489 T3057 T3056 arg1Of probes,oligonucleotide
R2490 T3057 T3058 arg1Of probes,were
R2491 T3057 T3059 arg2Of probes,synthesized
R2492 T3059 T3058 arg2Of synthesized,were
R2493 T3059 T3062 arg1Of synthesized,(
R2494 T3061 T3059 arg1Of IDT,synthesized
R2495 T3061 T3060 arg2Of IDT,by
R2496 T3063 T3062 arg2Of Coralville,(
R2497 T3063 T3064 arg1Of Coralville,","
R2498 T3063 T3065 arg1Of Coralville,IA
R2499 T3066 T3062 arg3Of ),(
R2500 T3068 T3067 arg1Of membranes,Nylon
R2501 T3068 T3069 arg1Of membranes,were
R2502 T3068 T3070 arg2Of membranes,purchased
R2503 T3070 T3069 arg2Of purchased,were
R2504 T3070 T3071 arg1Of purchased,from
R2505 T3074 T3071 arg2Of Sciences,from
R2506 T3074 T3072 arg1Of Sciences,Roche
R2507 T3074 T3073 arg1Of Sciences,Applied
R2508 T3074 T3075 arg1Of Sciences,(
R2509 T3076 T3075 arg2Of Indianapolis,(
R2510 T3076 T3077 arg1Of Indianapolis,","
R2511 T3076 T3078 arg1Of Indianapolis,IN
R2512 T3079 T3075 arg3Of ),(
R2513 T3083 T3080 arg1Of quantification,Western
R2514 T3083 T3081 arg1Of quantification,blot
R2515 T3083 T3082 arg1Of quantification,band
R2516 T3083 T3084 arg1Of quantification,was
R2517 T3083 T3085 arg2Of quantification,performed
R2518 T3085 T3084 arg2Of performed,was
R2519 T3085 T3086 arg1Of performed,with
R2520 T3090 T3088 arg1Of Digitizing,UN-SCAN-IT
R2521 T3090 T3089 arg1Of Digitizing,Gel
R2522 T3091 T3086 arg2Of software,with
R2523 T3091 T3087 arg1Of software,the
R2524 T3091 T3090 arg1Of software,Digitizing
R2525 T3091 T3092 arg1Of software,(
R2526 T3094 T3093 arg1Of Scientific,Silk
R2527 T3094 T3095 arg1Of Scientific,","
R2528 T3095 T3092 arg2Of ",",(
R2529 T3095 T3097 arg1Of ",",","
R2530 T3096 T3095 arg2Of Orem,","
R2531 T3098 T3097 arg2Of UT,","
R2532 T3099 T3092 arg3Of ),(
R2910 T3581 T3578 arg1Of Cell,Peripheral
R2911 T3581 T3579 arg1Of Cell,Blood
R2912 T3581 T3580 arg1Of Cell,Mononuclear
R2913 T3582 T3583 arg1Of Isolation,and
R2914 T3583 T3577 arg1Of and,Human
R2915 T3583 T3581 arg1Of and,Cell
R2916 T3584 T3583 arg2Of Stimulation,and
R2917 T3587 T3585 arg1Of cells,Human
R2918 T3587 T3586 arg1Of cells,mononuclear
R2919 T3587 T3588 arg1Of cells,were
R2920 T3587 T3589 arg2Of cells,isolated
R2921 T3589 T3588 arg2Of isolated,were
R2922 T3589 T3590 arg1Of isolated,from
R2923 T3593 T3590 arg2Of blood,from
R2924 T3593 T3591 arg1Of blood,the
R2925 T3593 T3592 arg1Of blood,peripheral
R2926 T3593 T3594 arg1Of blood,of
R2927 T3598 T3594 arg2Of volunteers,of
R2928 T3598 T3595 arg1Of volunteers,four
R2929 T3598 T3596 arg1Of volunteers,healthy
R2930 T3598 T3597 arg1Of volunteers,human
R2931 T3601 T3599 arg1Of size,The
R2932 T3601 T3600 arg1Of size,sample
R2933 T3601 T3602 arg1Of size,was
R2934 T3601 T3603 arg2Of size,chosen
R2935 T3603 T3602 arg2Of chosen,was
R2936 T3603 T3604 arg1Of chosen,from
R2937 T3603 T3616 arg1Of chosen,and
R2938 T3607 T3606 arg1Of published,previously
R2939 T3608 T3604 arg2Of work,from
R2940 T3608 T3605 arg1Of work,our
R2941 T3608 T3607 arg1Of work,published
R2942 T3608 T3609 arg1Of work,","
R2943 T3608 T3610 arg1Of work,which
R2944 T3608 T3611 arg1Of work,demonstrated
R2945 T3615 T3611 arg2Of isolation,demonstrated
R2946 T3615 T3612 arg1Of isolation,reliable
R2947 T3615 T3613 arg1Of isolation,results.10
R2948 T3615 T3614 arg1Of isolation,Cell
R2949 T3619 T3617 arg1Of experiments,all
R2950 T3619 T3618 arg1Of experiments,subsequent
R2951 T3619 T3620 arg1Of experiments,were
R2952 T3619 T3621 arg2Of experiments,conducted
R2953 T3621 T3616 arg2Of conducted,and
R2954 T3621 T3620 arg2Of conducted,were
R2955 T3621 T3622 arg1Of conducted,under
R2956 T3623 T3624 arg1Of sterile,and
R2957 T3625 T3624 arg2Of pyrogen-free,and
R2958 T3626 T3622 arg2Of conditions,under
R2959 T3626 T3623 arg1Of conditions,sterile
R2960 T3626 T3625 arg1Of conditions,pyrogen-free
R2961 T3627 T3628 arg2Of Blood,collected
R2962 T3627 T3632 arg1Of Blood,was
R2963 T3627 T3633 arg2Of Blood,incubated
R2964 T3628 T3629 arg1Of collected,in
R2965 T3631 T3629 arg2Of tubes,in
R2966 T3631 T3630 arg1Of tubes,heparin
R2967 T3633 T3632 arg2Of incubated,was
R2968 T3633 T3634 arg1Of incubated,with
R2969 T3633 T3637 arg1Of incubated,and
R2970 T3636 T3634 arg2Of T500,with
R2971 T3636 T3635 arg1Of T500,Dextran
R2972 T3640 T3638 arg1Of cells,the
R2973 T3640 T3639 arg1Of cells,red
R2974 T3640 T3641 arg1Of cells,were
R2975 T3640 T3642 arg2Of cells,sedimented
R2976 T3642 T3637 arg2Of sedimented,and
R2977 T3642 T3641 arg2Of sedimented,were
R2978 T3642 T3643 arg1Of sedimented,for
R2979 T3645 T3643 arg2Of minutes,for
R2980 T3645 T3644 arg1Of minutes,40
R2981 T3645 T3646 arg1Of minutes,at
R2982 T3648 T3646 arg2Of temperature,at
R2983 T3648 T3647 arg1Of temperature,room
R2984 T3651 T3649 arg1Of serum,The
R2985 T3651 T3650 arg1Of serum,resultant
R2986 T3651 T3652 arg1Of serum,was
R2987 T3651 T3654 arg2Of serum,washed
R2988 T3651 T3658 arg2Of serum,separated
R2989 T3654 T3655 arg1Of washed,with
R2990 T3654 T3657 arg1Of washed,and
R2991 T3656 T3655 arg2Of HBSS,with
R2992 T3657 T3652 arg2Of and,was
R2993 T3657 T3653 arg1Of and,then
R2994 T3658 T3657 arg2Of separated,and
R2995 T3658 T3663 arg1Of separated,according
R2996 T3662 T3658 arg1Of centrifugation,separated
R2997 T3662 T3659 arg2Of centrifugation,by
R2998 T3662 T3660 arg1Of centrifugation,Percoll
R2999 T3662 T3661 arg1Of centrifugation,gradient
R3000 T3664 T3663 arg2Of to,according
R3001 T3667 T3664 arg2Of instructions,to
R3002 T3667 T3665 arg1Of instructions,the
R3003 T3667 T3666 arg1Of instructions,manufacturer’s
R3004 T3669 T3668 arg1Of viability,Cell
R3005 T3669 T3670 arg1Of viability,was
R3006 T3669 T3671 arg2Of viability,assessed
R3007 T3671 T3670 arg2Of assessed,was
R3008 T3671 T3677 arg1Of assessed,","
R3009 T3671 T3678 arg1Of assessed,with
R3010 T3676 T3671 arg1Of exclusion,assessed
R3011 T3676 T3672 arg2Of exclusion,by
R3012 T3676 T3673 arg1Of exclusion,trypan
R3013 T3676 T3674 arg1Of exclusion,blue
R3014 T3676 T3675 arg1Of exclusion,dye
R3015 T3679 T3678 arg2Of purity,with
R3016 T3679 T3680 arg1Of purity,of
R3017 T3681 T3682 arg1Of greater,than
R3018 T3683 T3682 arg2Of 95,than
R3019 T3684 T3680 arg2Of %,of
R3020 T3684 T3681 arg1Of %,greater
R3021 T3686 T3685 arg2Of cells,Isolated
R3022 T3686 T3687 arg1Of cells,were
R3023 T3686 T3688 arg2Of cells,resuspended
R3024 T3688 T3687 arg2Of resuspended,were
R3025 T3688 T3689 arg1Of resuspended,in
R3026 T3688 T3701 arg1Of resuspended,at
R3027 T3690 T3689 arg2Of RPMI,in
R3028 T3690 T3691 arg1Of RPMI,1640
R3029 T3690 T3692 arg2Of RPMI,supplemented
R3030 T3692 T3693 arg1Of supplemented,with
R3031 T3696 T3694 arg1Of FBS,10
R3032 T3696 T3695 arg1Of FBS,%
R3033 T3696 T3697 arg1Of FBS,and
R3034 T3697 T3693 arg2Of and,with
R3035 T3698 T3699 arg1Of 5,mM
R3036 T3700 T3697 arg2Of HEPES,and
R3037 T3700 T3698 arg1Of HEPES,5
R3038 T3703 T3701 arg2Of concentration,at
R3039 T3703 T3702 arg1Of concentration,a
R3040 T3703 T3704 arg1Of concentration,of
R3041 T3707 T3704 arg2Of 107cells/mL,of
R3042 T3707 T3705 arg1Of 107cells/mL,1
R3043 T3707 T3706 arg1Of 107cells/mL,x
R3044 T3710 T3708 arg1Of experiment,Each
R3045 T3710 T3709 arg1Of experiment,subsequent
R3046 T3710 T3711 arg2Of experiment,listed
R3047 T3710 T3713 arg1Of experiment,was
R3048 T3710 T3714 arg2Of experiment,conducted
R3049 T3711 T3712 arg1Of listed,below
R3050 T3714 T3713 arg2Of conducted,was
R3051 T3714 T3715 arg1Of conducted,on
R3052 T3716 T3715 arg2Of samples,on
R3053 T3716 T3717 arg1Of samples,of
R3054 T3721 T3717 arg2Of cells,of
R3055 T3721 T3718 arg1Of cells,5
R3056 T3721 T3719 arg1Of cells,x
R3057 T3721 T3720 arg1Of cells,106
R3058 T3721 T3722 arg1Of cells,per
R3059 T3724 T3722 arg2Of group,per
R3060 T3724 T3723 arg1Of group,treatment
R3061 T3726 T3725 arg2Of cells,Isolated
R3062 T3726 T3727 arg1Of cells,were
R3063 T3726 T3728 arg2Of cells,stimulated
R3064 T3728 T3727 arg2Of stimulated,were
R3065 T3728 T3729 arg1Of stimulated,with
R3066 T3728 T3732 arg1Of stimulated,as
R3067 T3731 T3729 arg2Of HBSS,with
R3068 T3731 T3730 arg1Of HBSS,either
R3069 T3735 T3732 arg2Of control,as
R3070 T3735 T3733 arg1Of control,a
R3071 T3735 T3734 arg1Of control,negative
R3072 T3735 T3736 arg1Of control,","
R3073 T3737 T3738 arg1Of LPS,(
R3074 T3737 T3742 arg1Of LPS,","
R3075 T3740 T3738 arg2Of μg/mL,(
R3076 T3740 T3739 arg1Of μg/mL,1
R3077 T3741 T3738 arg3Of ),(
R3078 T3742 T3749 arg1Of ",",or
R3079 T3743 T3742 arg2Of PTX,","
R3080 T3743 T3744 arg1Of PTX,(
R3081 T3746 T3744 arg2Of mM,(
R3082 T3746 T3745 arg1Of mM,20
R3083 T3747 T3744 arg3Of ),(
R3084 T3749 T3736 arg2Of or,","
R3085 T3749 T3748 arg1Of or,","
R3086 T3749 T3754 arg1Of or,","
R3087 T3749 T3755 arg1Of or,at
R3088 T3749 T3759 arg1Of or,","
R3089 T3749 T3760 arg1Of or,for
R3090 T3753 T3749 arg2Of PTX,or
R3091 T3753 T3750 arg1Of PTX,concomitant
R3092 T3753 T3751 arg1Of PTX,LPS
R3093 T3753 T3752 arg1Of PTX,/
R3094 T3758 T3755 arg2Of concentrations,at
R3095 T3758 T3756 arg1Of concentrations,the
R3096 T3758 T3757 arg1Of concentrations,above-mentioned
R3097 T3762 T3760 arg2Of minutes,for
R3098 T3762 T3761 arg1Of minutes,30
R3099 T3762 T3763 arg1Of minutes,at
R3100 T3764 T3763 arg2Of 37ºC,at
R3101 T3765 T3766 arg1Of Cells,were
R3102 T3765 T3767 arg2Of Cells,placed
R3103 T3767 T3766 arg2Of placed,were
R3104 T3767 T3768 arg1Of placed,on
R3105 T3767 T3777 arg1Of placed,and
R3106 T3769 T3768 arg2Of ice,on
R3107 T3769 T3770 arg1Of ice,for
R3108 T3772 T3770 arg2Of minutes,for
R3109 T3772 T3771 arg1Of minutes,10
R3110 T3772 T3774 arg1Of minutes,stop
R3111 T3774 T3770 arg3Of stop,for
R3112 T3774 T3773 arg1Of stop,to
R3113 T3776 T3774 arg2Of reaction,stop
R3114 T3776 T3775 arg1Of reaction,the
R3115 T3779 T3778 arg1Of samples,the
R3116 T3779 T3780 arg1Of samples,were
R3117 T3779 T3782 arg2Of samples,stored
R3118 T3782 T3777 arg2Of stored,and
R3119 T3782 T3780 arg2Of stored,were
R3120 T3782 T3781 arg1Of stored,then
R3121 T3782 T3783 arg1Of stored,at
R3122 T3784 T3783 arg2Of −70°C,at
R3123 T3784 T3785 arg1Of −70°C,for
R3124 T3787 T3785 arg2Of analysis,for
R3125 T3787 T3786 arg1Of analysis,further
R3126 T3790 T3789 arg1Of times,stimulation
R3127 T3790 T3791 arg1Of times,and
R3128 T3791 T3788 arg1Of and,The
R3129 T3791 T3801 arg1Of and,were
R3130 T3791 T3802 arg2Of and,determined
R3131 T3792 T3791 arg2Of concentrations,and
R3132 T3792 T3793 arg1Of concentrations,of
R3133 T3794 T3795 arg1Of LPS,and
R3134 T3795 T3793 arg2Of and,of
R3135 T3795 T3797 arg2Of and,utilized
R3136 T3796 T3795 arg2Of PTX,and
R3137 T3797 T3798 arg1Of utilized,in
R3138 T3800 T3798 arg2Of study,in
R3139 T3800 T3799 arg1Of study,this
R3140 T3802 T3801 arg2Of determined,were
R3141 T3802 T3803 arg1Of determined,in
R3142 T3806 T3803 arg2Of studies,in
R3143 T3806 T3804 arg1Of studies,previous
R3144 T3806 T3805 arg1Of studies,pilot
R3145 T3806 T3807 arg2Of studies,done
R3146 T3807 T3808 arg1Of done,in
R3147 T3810 T3808 arg2Of laboratory,in
R3148 T3810 T3809 arg1Of laboratory,our
R3149 T3810 T3811 arg1Of laboratory,","
R3150 T3810 T3812 arg1Of laboratory,which
R3151 T3810 T3813 arg1Of laboratory,examined
R3152 T3815 T3813 arg2Of effects,examined
R3153 T3815 T3814 arg1Of effects,the
R3154 T3815 T3816 arg1Of effects,of
R3155 T3815 T3821 arg1Of effects,on
R3156 T3818 T3816 arg2Of concentrations,of
R3157 T3818 T3817 arg1Of concentrations,increasing
R3158 T3818 T3819 arg1Of concentrations,of
R3159 T3820 T3819 arg2Of PTX,of
R3160 T3824 T3821 arg2Of production,on
R3161 T3824 T3822 arg1Of production,LPS-induced
R3162 T3824 T3823 arg1Of production,TNF-α
R3163 T3825 T3826 arg1Of LPS,at
R3164 T3825 T3834 arg1Of LPS,at
R3165 T3825 T3840 arg1Of LPS,were
R3166 T3828 T3826 arg2Of concentration,at
R3167 T3828 T3827 arg1Of concentration,a
R3168 T3828 T3829 arg1Of concentration,of
R3169 T3831 T3832 arg1Of μg/mL,and
R3170 T3832 T3829 arg2Of and,of
R3171 T3832 T3830 arg1Of and,1
R3172 T3833 T3832 arg2Of PTX,and
R3173 T3836 T3834 arg2Of concentration,at
R3174 T3836 T3835 arg1Of concentration,a
R3175 T3836 T3837 arg1Of concentration,of
R3176 T3839 T3837 arg2Of mM,of
R3177 T3839 T3838 arg1Of mM,20
R3178 T3843 T3840 arg2Of concentrations,were
R3179 T3843 T3841 arg1Of concentrations,the
R3180 T3843 T3842 arg1Of concentrations,minimum
R3181 T3843 T3844 arg1Of concentrations,necessary
R3182 T3846 T3844 arg2Of produce,necessary
R3183 T3846 T3845 arg1Of produce,to
R3184 T3846 T3857 arg1Of produce,","
R3185 T3846 T3858 arg1Of produce,respectively
R3186 T3846 T3859 arg1Of produce,","
R3187 T3846 T3860 arg1Of produce,in
R3188 T3848 T3849 arg1Of reproducible,and
R3189 T3850 T3849 arg2Of reliable,and
R3190 T3851 T3852 arg1Of up-regulation,and
R3191 T3852 T3846 arg2Of and,produce
R3192 T3852 T3847 arg1Of and,a
R3193 T3852 T3848 arg1Of and,reproducible
R3194 T3852 T3850 arg1Of and,reliable
R3195 T3852 T3854 arg1Of and,in
R3196 T3853 T3852 arg2Of down-regulation,and
R3197 T3856 T3854 arg2Of production,in
R3198 T3856 T3855 arg1Of production,TNF-α
R3199 T3862 T3860 arg2Of assays,in
R3200 T3862 T3861 arg1Of assays,quantitative
R3201 T3862 T3863 arg1Of assays,(
R3202 T3864 T3863 arg2Of data,(
R3203 T3864 T3866 arg2Of data,shown
R3204 T3866 T3865 arg1Of shown,not
R3205 T3867 T3863 arg3Of ),(
R3302 T4023 T4024 arg1Of Effect,of
R3303 T4023 T4026 arg1Of Effect,on
R3304 T4023 T4030 arg1Of Effect,by
R3305 T4025 T4024 arg2Of PTX,of
R3306 T4029 T4026 arg2Of production,on
R3307 T4029 T4027 arg1Of production,LPS-induced
R3308 T4029 T4028 arg1Of production,TNF-α
R3309 T4032 T4030 arg2Of cells,by
R3310 T4032 T4031 arg1Of cells,mononuclear
R3311 T4034 T4033 arg1Of concentration,The
R3312 T4034 T4035 arg1Of concentration,of
R3313 T4034 T4037 arg1Of concentration,was
R3314 T4034 T4039 arg2Of concentration,determined
R3315 T4036 T4035 arg2Of TNF-α,of
R3316 T4039 T4037 arg2Of determined,was
R3317 T4039 T4038 arg1Of determined,quantitatively
R3318 T4041 T4039 arg1Of ELISA,determined
R3319 T4041 T4040 arg2Of ELISA,by
R3320 T4041 T4042 arg1Of ELISA,in
R3321 T4044 T4042 arg2Of media,in
R3322 T4044 T4043 arg1Of media,the
R3323 T4044 T4045 arg1Of media,of
R3324 T4044 T4063 arg1Of media,","
R3325 T4044 T4064 arg1Of media,at
R3326 T4046 T4045 arg2Of cells,of
R3327 T4046 T4047 arg2Of cells,exposed
R3328 T4047 T4048 arg1Of exposed,to
R3329 T4050 T4048 arg2Of treatments,to
R3330 T4050 T4049 arg1Of treatments,the
R3331 T4050 T4051 arg2Of treatments,described
R3332 T4051 T4052 arg1Of described,above
R3333 T4051 T4053 arg1Of described,after
R3334 T4051 T4055 arg1Of described,for
R3335 T4054 T4053 arg2Of stimulation,after
R3336 T4056 T4055 arg2Of up,for
R3337 T4056 T4057 arg1Of up,to
R3338 T4059 T4057 arg2Of maximum,to
R3339 T4059 T4058 arg1Of maximum,a
R3340 T4059 T4060 arg1Of maximum,of
R3341 T4062 T4060 arg2Of hours,of
R3342 T4062 T4061 arg1Of hours,18
R3343 T4066 T4064 arg2Of intervals,at
R3344 T4066 T4065 arg1Of intervals,3-hour
R3345 T4068 T4067 arg1Of results,The
R3346 T4068 T4069 arg1Of results,are
R3347 T4068 T4070 arg2Of results,expressed
R3348 T4070 T4069 arg2Of expressed,are
R3349 T4070 T4071 arg1Of expressed,in
R3350 T4072 T4071 arg2Of pg/mL,in
R349 T451 T452 arg1Of Insights,into
R350 T451 T462 arg1Of Insights,:
R351 T454 T452 arg2Of Regulation,into
R352 T454 T453 arg1Of Regulation,the
R353 T454 T455 arg1Of Regulation,of
R354 T454 T458 arg1Of Regulation,in
R355 T457 T455 arg2Of Production,of
R356 T457 T456 arg1Of Production,TNF-α
R357 T461 T458 arg2Of Cells,in
R358 T461 T459 arg1Of Cells,Human
R359 T461 T460 arg1Of Cells,Mononuclear
R360 T464 T463 arg1Of Effects,The
R361 T464 T465 arg1Of Effects,of
R362 T468 T465 arg2Of Inhibition,of
R363 T468 T466 arg1Of Inhibition,Non-Specific
R364 T468 T467 arg1Of Inhibition,Phosphodiesterase
R365 T471 T470 arg1Of objective,The
R366 T471 T472 arg1Of objective,of
R367 T471 T475 arg1Of objective,was
R368 T474 T472 arg2Of study,of
R369 T474 T473 arg1Of study,this
R3696 T4475 T4476 arg1Of SDS-PAGE,and
R3697 T4476 T4478 arg1Of and,(
R3698 T4477 T4476 arg2Of Immunoblotting,and
R3699 T4479 T4480 arg1Of I-κBα,","
R370 T477 T475 arg2Of determine,was
R3700 T4480 T4484 arg1Of ",",and
R3701 T4482 T4480 arg2Of p65,","
R3702 T4482 T4481 arg1Of p65,NF-κB
R3703 T4484 T4478 arg2Of and,(
R3704 T4484 T4483 arg1Of and,","
R3705 T4485 T4484 arg2Of CREB,and
R3706 T4486 T4478 arg3Of ),(
R3707 T4488 T4487 arg2Of stimulation,Following
R3708 T4490 T4491 arg1Of PBMCs,were
R3709 T4490 T4492 arg2Of PBMCs,washed
R371 T477 T476 arg1Of determine,to
R3710 T4490 T4497 arg2Of PBMCs,centrifuged
R3711 T4490 T4499 arg1Of PBMCs,collect
R3712 T4492 T4493 arg1Of washed,with
R3713 T4492 T4496 arg1Of washed,and
R3714 T4495 T4493 arg2Of PBS,with
R3715 T4495 T4494 arg1Of PBS,ice-cold
R3716 T4496 T4487 arg1Of and,Following
R3717 T4496 T4489 arg1Of and,","
R3718 T4496 T4491 arg2Of and,were
R3719 T4497 T4496 arg2Of centrifuged,and
R372 T479 T477 arg2Of effect,determine
R3720 T4499 T4497 arg3Of collect,centrifuged
R3721 T4499 T4498 arg1Of collect,to
R3722 T4502 T4499 arg2Of pellet,collect
R3723 T4502 T4500 arg1Of pellet,a
R3724 T4502 T4501 arg1Of pellet,cell
R3725 T4504 T4503 arg1Of pellet,The
R3726 T4504 T4505 arg1Of pellet,was
R3727 T4504 T4506 arg2Of pellet,resuspended
R3728 T4506 T4505 arg2Of resuspended,was
R3729 T4506 T4507 arg1Of resuspended,in
R373 T479 T478 arg1Of effect,the
R3730 T4511 T4507 arg2Of buffer,in
R3731 T4511 T4508 arg1Of buffer,ice-cold
R3732 T4511 T4509 arg1Of buffer,SDS
R3733 T4511 T4510 arg1Of buffer,sample
R3734 T4511 T4512 arg2Of buffer,supplemented
R3735 T4512 T4513 arg1Of supplemented,with
R3736 T4514 T4515 arg1Of 100,mM
R3737 T4516 T4513 arg2Of dithiothreitol,with
R3738 T4516 T4514 arg1Of dithiothreitol,100
R3739 T4517 T4518 arg1Of Cytoplasmic,and
R374 T479 T480 arg1Of effect,of
R3740 T4519 T4518 arg2Of nuclear,and
R3741 T4520 T4517 arg1Of extracts,Cytoplasmic
R3742 T4520 T4519 arg1Of extracts,nuclear
R3743 T4520 T4521 arg1Of extracts,were
R3744 T4520 T4522 arg2Of extracts,isolated
R3745 T4522 T4521 arg2Of isolated,were
R3746 T4522 T4523 arg1Of isolated,with
R3747 T4522 T4536 arg1Of isolated,according
R3748 T4525 T4526 arg1Of nuclear,and
R3749 T4527 T4526 arg2Of cytoplasmic,and
R375 T479 T484 arg1Of effect,on
R3750 T4529 T4523 arg2Of reagents,with
R3751 T4529 T4524 arg1Of reagents,NE-PER
R3752 T4529 T4525 arg1Of reagents,nuclear
R3753 T4529 T4527 arg1Of reagents,cytoplasmic
R3754 T4529 T4528 arg1Of reagents,extraction
R3755 T4529 T4530 arg1Of reagents,with
R3756 T4535 T4530 arg2Of Cocktail,with
R3757 T4535 T4531 arg1Of Cocktail,1x
R3758 T4535 T4532 arg1Of Cocktail,Halt
R3759 T4535 T4533 arg1Of Cocktail,Protease
R376 T483 T480 arg2Of inhibition,of
R3760 T4535 T4534 arg1Of Cocktail,Inhibitor
R3761 T4537 T4536 arg2Of to,according
R3762 T4540 T4537 arg2Of instructions,to
R3763 T4540 T4538 arg1Of instructions,the
R3764 T4540 T4539 arg1Of instructions,manufacturer’s
R3765 T4542 T4541 arg1Of concentrations,Protein
R3766 T4542 T4543 arg1Of concentrations,were
R3767 T4542 T4544 arg2Of concentrations,determined
R3768 T4544 T4543 arg2Of determined,were
R3769 T4544 T4545 arg1Of determined,with
R377 T483 T481 arg1Of inhibition,nonspecific
R3770 T4544 T4554 arg1Of determined,according
R3771 T4550 T4545 arg2Of kit,with
R3772 T4550 T4546 arg1Of kit,the
R3773 T4550 T4547 arg1Of kit,BCA
R3774 T4550 T4548 arg1Of kit,protein
R3775 T4550 T4549 arg1Of kit,reagent
R3776 T4550 T4551 arg1Of kit,for
R3777 T4553 T4551 arg2Of sample,for
R3778 T4553 T4552 arg1Of sample,each
R3779 T4555 T4554 arg2Of to,according
R378 T483 T482 arg1Of inhibition,phosphodiesterase
R3780 T4558 T4555 arg2Of curve,to
R3781 T4558 T4556 arg1Of curve,a
R3782 T4558 T4557 arg1Of curve,standardized
R3783 T4558 T4559 arg1Of curve,for
R3784 T4560 T4559 arg2Of albumin,for
R3785 T4562 T4561 arg1Of lysates,Cell
R3786 T4562 T4563 arg1Of lysates,were
R3787 T4562 T4564 arg2Of lysates,collected
R3788 T4564 T4563 arg2Of collected,were
R3789 T4564 T4565 arg1Of collected,by
R379 T487 T485 arg1Of activation,transcription
R3790 T4566 T4565 arg2Of boiling,by
R3791 T4566 T4569 arg1Of boiling,in
R3792 T4568 T4566 arg2Of samples,boiling
R3793 T4568 T4567 arg1Of samples,the
R3794 T4573 T4569 arg2Of bath,in
R3795 T4573 T4570 arg1Of bath,a
R3796 T4573 T4571 arg1Of bath,100ºC
R3797 T4573 T4572 arg1Of bath,water
R3798 T4573 T4574 arg1Of bath,for
R3799 T4576 T4574 arg2Of minutes,for
R380 T487 T486 arg1Of activation,factor
R3800 T4576 T4575 arg1Of minutes,5
R3801 T4578 T4577 arg1Of μg,Ten
R3802 T4578 T4579 arg1Of μg,of
R3803 T4578 T4581 arg1Of μg,per
R3804 T4578 T4583 arg1Of μg,was
R3805 T4578 T4584 arg2Of μg,separated
R3806 T4578 T4597 arg2Of μg,transferred
R3807 T4580 T4579 arg2Of protein,of
R3808 T4582 T4581 arg2Of sample,per
R3809 T4584 T4589 arg1Of separated,through
R381 T487 T488 arg1Of activation,and
R3810 T4584 T4596 arg1Of separated,and
R3811 T4588 T4584 arg1Of electrophoresis,separated
R3812 T4588 T4585 arg2Of electrophoresis,by
R3813 T4588 T4586 arg1Of electrophoresis,SDS-polyacrylamide
R3814 T4588 T4587 arg1Of electrophoresis,gel
R3815 T4590 T4591 arg1Of 8–16,%
R3816 T4595 T4589 arg2Of gels,through
R3817 T4595 T4590 arg1Of gels,8–16
R3818 T4595 T4592 arg1Of gels,tris-glycine
R3819 T4595 T4593 arg1Of gels,polyacrylamide
R382 T488 T484 arg2Of and,on
R3820 T4595 T4594 arg1Of gels,gradient
R3821 T4596 T4583 arg2Of and,was
R3822 T4597 T4596 arg2Of transferred,and
R3823 T4597 T4598 modOf transferred,to
R3824 T4599 T4598 arg1Of nitrocellulose,to
R3825 T4600 T4599 arg2Of membranes,nitrocellulose
R3826 T4602 T4601 arg1Of membranes,The
R3827 T4602 T4603 arg1Of membranes,were
R3828 T4602 T4604 arg2Of membranes,blocked
R3829 T4604 T4603 arg2Of blocked,were
R383 T488 T496 arg1Of and,in
R3830 T4604 T4605 arg1Of blocked,with
R3831 T4606 T4607 arg1Of 5,%
R3832 T4608 T4605 arg2Of milk,with
R3833 T4608 T4606 arg1Of milk,5
R3834 T4608 T4609 arg1Of milk,in
R3835 T4611 T4609 arg2Of saline/Tween,in
R3836 T4611 T4610 arg1Of saline/Tween,Tris-buffered
R3837 T4611 T4612 arg1Of saline/Tween,20
R3838 T4611 T4613 arg1Of saline/Tween,(
R3839 T4611 T4621 arg1Of saline/Tween,for
R384 T491 T489 arg1Of factor-alpha,tumor
R3840 T4615 T4613 arg2Of Scientific,(
R3841 T4615 T4614 arg1Of Scientific,Fischer
R3842 T4615 T4616 arg1Of Scientific,","
R3843 T4617 T4616 arg2Of Pittsburgh,","
R3844 T4617 T4618 arg1Of Pittsburgh,","
R3845 T4619 T4618 arg2Of PA,","
R3846 T4620 T4613 arg3Of ),(
R3847 T4623 T4621 arg2Of hour,for
R3848 T4623 T4622 arg1Of hour,1
R3849 T4625 T4624 arg1Of extracts,Cytoplasmic
R385 T491 T490 arg1Of factor-alpha,necrosis
R3850 T4625 T4626 arg1Of extracts,were
R3851 T4625 T4627 arg2Of extracts,incubated
R3852 T4627 T4626 arg2Of incubated,were
R3853 T4627 T4628 arg1Of incubated,with
R3854 T4627 T4637 arg1Of incubated,","
R3855 T4627 T4638 arg1Of incubated,while
R3856 T4631 T4628 arg2Of antibody,with
R3857 T4631 T4629 arg2Of antibody,phosphorylated
R3858 T4631 T4630 arg1Of antibody,I-κBα
R3859 T4631 T4632 arg1Of antibody,(
R386 T491 T492 arg1Of factor-alpha,(
R3860 T4633 T4634 arg1Of 1,:
R3861 T4634 T4632 arg2Of :,(
R3862 T4635 T4634 arg2Of 200,:
R3863 T4636 T4632 arg3Of ),(
R3864 T4640 T4639 arg1Of extracts,nuclear
R3865 T4640 T4641 arg1Of extracts,were
R3866 T4640 T4642 arg2Of extracts,incubated
R3867 T4642 T4638 arg2Of incubated,while
R3868 T4642 T4641 arg2Of incubated,were
R3869 T4642 T4643 arg1Of incubated,with
R387 T493 T492 arg2Of TNF-α,(
R3870 T4642 T4664 arg1Of incubated,at
R3871 T4648 T4644 arg1Of antibody,either
R3872 T4648 T4645 arg2Of antibody,phosphorylated
R3873 T4648 T4646 arg1Of antibody,NF-κB
R3874 T4648 T4647 arg1Of antibody,p65
R3875 T4648 T4649 arg1Of antibody,(
R3876 T4648 T4654 arg1Of antibody,or
R3877 T4650 T4651 arg1Of 1,:
R3878 T4651 T4649 arg2Of :,(
R3879 T4652 T4651 arg2Of 500,:
R388 T494 T492 arg3Of ),(
R3880 T4653 T4649 arg3Of ),(
R3881 T4654 T4643 arg2Of or,with
R3882 T4657 T4654 arg2Of antibody,or
R3883 T4657 T4655 arg2Of antibody,phosphorylated
R3884 T4657 T4656 arg1Of antibody,CREB
R3885 T4657 T4658 arg1Of antibody,(
R3886 T4657 T4663 arg1Of antibody,overnight
R3887 T4659 T4660 arg1Of 1,:
R3888 T4660 T4658 arg2Of :,(
R3889 T4661 T4660 arg2Of 500,:
R389 T495 T488 arg2Of production,and
R3890 T4662 T4658 arg3Of ),(
R3891 T4665 T4664 arg2Of 4°C,at
R3892 T4665 T4666 arg1Of 4°C,in
R3893 T4668 T4666 arg2Of experiments,in
R3894 T4668 T4667 arg1Of experiments,separate
R3895 T4670 T4669 arg1Of membranes,The
R3896 T4670 T4671 arg1Of membranes,were
R3897 T4670 T4672 arg2Of membranes,washed
R3898 T4670 T4678 arg2Of membranes,incubated
R3899 T4672 T4673 arg1Of washed,with
R390 T495 T491 arg1Of production,factor-alpha
R3900 T4672 T4677 arg1Of washed,and
R3901 T4675 T4673 arg2Of saline/Tween,with
R3902 T4675 T4674 arg1Of saline/Tween,Tris-buffered
R3903 T4675 T4676 arg1Of saline/Tween,20
R3904 T4677 T4671 arg2Of and,were
R3905 T4678 T4677 arg2Of incubated,and
R3906 T4678 T4679 arg1Of incubated,for
R3907 T4678 T4682 arg1Of incubated,at
R3908 T4681 T4679 arg2Of hour,for
R3909 T4681 T4680 arg1Of hour,1
R391 T499 T498 arg2Of LPS,(
R3910 T4684 T4682 arg2Of temperature,at
R3911 T4684 T4683 arg1Of temperature,room
R3912 T4684 T4685 arg1Of temperature,with
R3913 T4688 T4685 arg2Of antibody,with
R3914 T4688 T4686 arg1Of antibody,the
R3915 T4688 T4687 arg1Of antibody,secondary
R3916 T4693 T4690 arg1Of IgG,horseradish
R3917 T4693 T4691 arg1Of IgG,peroxidase-linked
R3918 T4693 T4692 arg1Of IgG,anti-rabbit
R3919 T4693 T4694 arg1Of IgG,diluted
R392 T500 T498 arg3Of ),(
R3920 T4694 T4671 modOf diluted,were
R3921 T4694 T4689 arg1Of diluted,","
R3922 T4694 T4696 arg1Of diluted,:
R3923 T4695 T4694 arg2Of 1,diluted
R3924 T4697 T4694 arg3Of 2000,diluted
R3925 T4697 T4698 arg1Of 2000,in
R3926 T4699 T4698 arg2Of blocking,in
R3927 T4700 T4699 arg2Of solution,blocking
R3928 T4703 T4701 arg2Of washing,After
R3929 T4703 T4702 arg2Of washing,repeated
R393 T501 T497 arg1Of -stimulated,lipopolysaccharide
R3930 T4703 T4704 arg1Of washing,of
R3931 T4706 T4704 arg2Of membrane,of
R3932 T4706 T4705 arg1Of membrane,the
R3933 T4713 T4708 arg1Of Kit,the
R3934 T4713 T4709 arg1Of Kit,Supersignal
R3935 T4713 T4710 arg1Of Kit,West
R3936 T4713 T4711 arg1Of Kit,Pico
R3937 T4713 T4712 arg1Of Kit,Chemiluminescent
R3938 T4713 T4714 arg1Of Kit,was
R3939 T4713 T4715 arg2Of Kit,applied
R394 T501 T498 arg1Of -stimulated,(
R3940 T4715 T4701 arg1Of applied,After
R3941 T4715 T4707 arg1Of applied,","
R3942 T4715 T4714 arg2Of applied,was
R3943 T4715 T4716 arg1Of applied,for
R3944 T4718 T4716 arg2Of detection,for
R3945 T4718 T4717 arg1Of detection,antibody
R3946 T4718 T4719 arg1Of detection,per
R3947 T4722 T4719 arg2Of instructions,per
R3948 T4722 T4720 arg1Of instructions,the
R3949 T4722 T4721 arg1Of instructions,manufacturer’s
R395 T504 T496 arg2Of cells,in
R3950 T4725 T4723 arg1Of data,Western
R3951 T4725 T4724 arg1Of data,blot
R3952 T4725 T4726 arg1Of data,is
R3953 T4725 T4727 arg2Of data,presented
R3954 T4727 T4726 arg2Of presented,is
R3955 T4727 T4728 arg1Of presented,as
R3956 T4730 T4728 arg2Of percentage,as
R3957 T4730 T4729 arg1Of percentage,a
R3958 T4730 T4731 arg1Of percentage,of
R3959 T4733 T4731 arg2Of stimulation,of
R396 T504 T501 arg1Of cells,-stimulated
R3960 T4733 T4732 arg1Of stimulation,LPS
R3961 T4735 T4734 arg1Of percentage,The
R3962 T4735 T4736 arg1Of percentage,of
R3963 T4735 T4739 arg1Of percentage,was
R3964 T4735 T4740 arg2Of percentage,calculated
R3965 T4738 T4736 arg2Of stimulation,of
R3966 T4738 T4737 arg1Of stimulation,LPS
R3967 T4740 T4739 arg2Of calculated,was
R3968 T4740 T4741 arg1Of calculated,by
R3969 T4742 T4741 arg2Of dividing,by
R397 T504 T502 arg1Of cells,human
R3970 T4747 T4742 arg2Of total,dividing
R3971 T4747 T4743 arg1Of total,the
R3972 T4747 T4744 arg1Of total,mean
R3973 T4747 T4745 arg1Of total,band
R3974 T4747 T4746 arg1Of total,pixel
R3975 T4747 T4748 arg1Of total,for
R3976 T4751 T4748 arg2Of arm,for
R3977 T4751 T4749 arg1Of arm,each
R3978 T4751 T4750 arg1Of arm,treatment
R3979 T4751 T4752 arg2Of arm,divided
R398 T504 T503 arg1Of cells,mononuclear
R3980 T4757 T4752 arg1Of total,divided
R3981 T4757 T4753 arg2Of total,by
R3982 T4757 T4754 arg1Of total,the
R3983 T4757 T4755 arg1Of total,mean
R3984 T4757 T4756 arg1Of total,pixel
R3985 T4757 T4758 arg1Of total,of
R3986 T4759 T4758 arg2Of samples,of
R3987 T4759 T4760 arg2Of samples,stimulated
R3988 T4759 T4764 arg1Of samples,multiplying
R3989 T4760 T4761 arg1Of stimulated,with
R399 T507 T506 arg1Of production,The
R3990 T4760 T4763 arg1Of stimulated,and
R3991 T4762 T4761 arg2Of LPS,with
R3992 T4764 T4763 arg2Of multiplying,and
R3993 T4764 T4765 arg1Of multiplying,by
R3994 T4766 T4765 arg2Of 100,by
R3995 T4770 T4769 arg1Of stimulation,LPS
R3996 T4770 T4771 arg1Of stimulation,is
R3997 T4770 T4772 arg2Of stimulation,reported
R3998 T4772 T4771 arg2Of reported,is
R3999 T4772 T4773 arg1Of reported,as
R400 T507 T508 arg1Of production,of
R4000 T4772 T4776 arg1Of reported,and
R4001 T4775 T4773 arg2Of %,as
R4002 T4775 T4774 arg1Of %,100
R4003 T4776 T4767 arg1Of and,Thus
R4004 T4776 T4768 arg1Of and,","
R4005 T4777 T4778 arg1Of each,of
R4006 T4777 T4782 arg1Of each,is
R4007 T4777 T4783 arg2Of each,reported
R4008 T4781 T4778 arg2Of arms,of
R4009 T4781 T4779 arg1Of arms,the
R401 T507 T510 arg1Of production,following
R4010 T4781 T4780 arg1Of arms,treatment
R4011 T4783 T4776 arg2Of reported,and
R4012 T4783 T4782 arg2Of reported,is
R4013 T4783 T4784 arg1Of reported,as
R4014 T4786 T4784 arg2Of percent,as
R4015 T4786 T4785 arg1Of percent,a
R4016 T4786 T4787 arg1Of percent,of
R4017 T4789 T4787 arg2Of stimulation,of
R4018 T4789 T4788 arg1Of stimulation,LPS
R402 T507 T513 arg1Of production,is
R403 T509 T508 arg2Of TNF-α,of
R404 T512 T510 arg2Of stimulation,following
R405 T512 T511 arg1Of stimulation,LPS
R406 T514 T513 arg2Of one,is
R407 T514 T515 arg1Of one,of
R408 T518 T515 arg2Of steps,of
R409 T518 T516 arg1Of steps,the
R410 T518 T517 arg1Of steps,key
R411 T518 T519 arg1Of steps,in
R412 T521 T522 arg1Of sepsis,and
R413 T522 T519 arg2Of and,in
R414 T522 T520 arg1Of and,bacterial
R415 T523 T522 arg2Of inflammation,and
R416 T525 T524 arg1Of mechanism,The
R417 T525 T526 arg2Of mechanism,by
R418 T525 T527 arg1Of mechanism,which
R419 T525 T538 arg1Of mechanism,remains
R420 T525 T539 arg1Of mechanism,unclear
R421 T529 T528 arg1Of inhibition,phosphodiesterase
R422 T529 T530 arg1Of inhibition,alters
R423 T530 T526 arg1Of alters,by
R424 T530 T533 arg1Of alters,in
R425 T532 T530 arg2Of production,alters
R426 T532 T531 arg1Of production,TNF-α
R427 T535 T533 arg2Of presence,in
R428 T535 T534 arg1Of presence,the
R429 T535 T536 arg1Of presence,of
R430 T537 T536 arg2Of LPS,of
R431 T539 T538 arg2Of unclear,remains
R432 T543 T541 arg1Of cells,Human
R433 T543 T542 arg1Of cells,mononuclear
R434 T543 T544 arg1Of cells,were
R435 T543 T545 arg2Of cells,stimulated
R4358 T5231 T5232 arg1Of NF-κB,and
R4359 T5233 T5232 arg2Of CREB,and
R436 T545 T544 arg2Of stimulated,were
R4360 T5237 T5231 arg1Of Assay,NF-κB
R4361 T5237 T5233 arg1Of Assay,CREB
R4362 T5237 T5234 arg1Of Assay,Electrophoretic
R4363 T5237 T5235 arg1Of Assay,Mobility
R4364 T5237 T5236 arg1Of Assay,Shift
R4365 T5237 T5238 arg1Of Assay,(
R4366 T5239 T5238 arg2Of EMSA,(
R4367 T5240 T5238 arg3Of ),(
R4368 T5245 T5243 arg1Of EMSA,LightShift
R4369 T5245 T5244 arg1Of EMSA,Chemiluminescent
R437 T545 T546 arg1Of stimulated,with
R4370 T5246 T5241 arg1Of Kit,The
R4371 T5246 T5242 arg1Of Kit,non-radioactive
R4372 T5246 T5245 arg1Of Kit,EMSA
R4373 T5246 T5247 arg1Of Kit,was
R4374 T5246 T5248 arg2Of Kit,used
R4375 T5248 T5247 arg2Of used,was
R4376 T5248 T5249 modOf used,to
R4377 T5250 T5249 arg1Of detect,to
R4378 T5252 T5250 arg2Of interactions,detect
R4379 T5252 T5251 arg1Of interactions,DNA-protein
R438 T547 T546 arg2Of LPS,with
R4380 T5259 T5253 arg1Of oligonucleotide,The
R4381 T5259 T5254 arg1Of oligonucleotide,NF-κB
R4382 T5259 T5255 arg1Of oligonucleotide,3′
R4383 T5259 T5256 arg1Of oligonucleotide,biotin
R4384 T5259 T5257 arg1Of oligonucleotide,end-labeled
R4385 T5259 T5258 arg1Of oligonucleotide,DNA
R4386 T5259 T5260 arg2Of oligonucleotide,used
R4387 T5259 T5267 arg1Of oligonucleotide,was
R4388 T5260 T5261 arg1Of used,as
R4389 T5263 T5261 arg2Of probe,as
R439 T547 T548 arg1Of LPS,(
R4390 T5263 T5262 arg1Of probe,a
R4391 T5263 T5264 arg1Of probe,for
R4392 T5266 T5264 arg2Of EMSA,for
R4393 T5266 T5265 arg1Of EMSA,the
R4394 T5272 T5267 arg2Of construct,was
R4395 T5272 T5268 arg1Of construct,a
R4396 T5272 T5269 arg1Of construct,42-bp
R4397 T5272 T5270 arg1Of construct,double
R4398 T5272 T5271 arg1Of construct,stranded
R4399 T5272 T5273 arg1Of construct,(
R440 T547 T552 arg1Of LPS,","
R4400 T5272 T5278 arg1Of construct,containing
R4401 T5276 T5273 arg2Of 3′,(
R4402 T5276 T5274 arg1Of 3′,5′-TTGTTACAA-GGGGACTTTCCGCTGGGGACTTTCCAGGGAGGC
R4403 T5276 T5275 arg1Of 3′,–
R4404 T5277 T5273 arg3Of ),(
R4405 T5284 T5278 arg2Of sites,containing
R4406 T5284 T5279 arg1Of sites,two
R4407 T5284 T5280 arg1Of sites,tandemly
R4408 T5284 T5281 arg2Of sites,repeated
R4409 T5284 T5282 arg1Of sites,NF-κB
R441 T547 T553 arg1Of LPS,in
R4410 T5284 T5283 arg1Of sites,binding
R4411 T5284 T5285 arg1Of sites,(
R4412 T5286 T5285 arg2Of underlined,(
R4413 T5287 T5285 arg3Of ),(
R4414 T5288 T5289 arg1Of Specificity,was
R4415 T5288 T5290 arg2Of Specificity,determined
R4416 T5290 T5289 arg2Of determined,was
R4417 T5294 T5290 arg1Of assay,determined
R4418 T5294 T5291 arg2Of assay,by
R4419 T5294 T5292 arg1Of assay,a
R442 T547 T566 arg1Of LPS,","
R4420 T5294 T5293 arg1Of assay,competition
R4421 T5294 T5295 arg1Of assay,with
R4422 T5297 T5295 arg2Of addition,with
R4423 T5297 T5296 arg1Of addition,the
R4424 T5297 T5298 arg1Of addition,of
R4425 T5300 T5299 arg1Of molar,200
R4426 T5301 T5298 arg2Of excess,of
R4427 T5301 T5300 arg1Of excess,molar
R4428 T5301 T5302 arg1Of excess,of
R4429 T5305 T5303 arg1Of stranded,unlabeled
R443 T550 T548 arg2Of μg/mL,(
R4430 T5305 T5304 arg1Of stranded,double
R4431 T5307 T5302 arg2Of oligonucleotide,of
R4432 T5307 T5305 arg1Of oligonucleotide,stranded
R4433 T5307 T5306 arg1Of oligonucleotide,NF-κB
R4434 T5314 T5308 arg1Of oligonucleotide,The
R4435 T5314 T5309 arg1Of oligonucleotide,CREB
R4436 T5314 T5310 arg1Of oligonucleotide,3′
R4437 T5314 T5311 arg1Of oligonucleotide,biotin
R4438 T5314 T5312 arg1Of oligonucleotide,end-labeled
R4439 T5314 T5313 arg1Of oligonucleotide,DNA
R444 T550 T549 arg1Of μg/mL,1
R4440 T5314 T5315 arg2Of oligonucleotide,used
R4441 T5314 T5322 arg1Of oligonucleotide,was
R4442 T5315 T5316 arg1Of used,as
R4443 T5318 T5316 arg2Of probe,as
R4444 T5318 T5317 arg1Of probe,a
R4445 T5318 T5319 arg1Of probe,for
R4446 T5321 T5319 arg2Of EMSA,for
R4447 T5321 T5320 arg1Of EMSA,the
R4448 T5327 T5322 arg2Of construct,was
R4449 T5327 T5323 arg1Of construct,a
R445 T551 T548 arg3Of ),(
R4450 T5327 T5324 arg1Of construct,23-bp
R4451 T5327 T5325 arg1Of construct,double
R4452 T5327 T5326 arg1Of construct,stranded
R4453 T5327 T5328 arg1Of construct,(
R4454 T5327 T5336 arg1Of construct,containing
R4455 T5334 T5328 arg2Of 3′,(
R4456 T5334 T5329 arg1Of 3′,5′-TTT
R4457 T5334 T5330 arg1Of 3′,TCG
R4458 T5334 T5331 arg1Of 3′,AGC
R4459 T5334 T5332 arg1Of 3′,TCTGACGTCAGA-GC
R446 T555 T556 arg1Of presence,and
R4460 T5334 T5333 arg1Of 3′,–
R4461 T5335 T5328 arg3Of ),(
R4462 T5340 T5336 arg2Of sequence,containing
R4463 T5340 T5337 arg1Of sequence,the
R4464 T5340 T5338 arg1Of sequence,CRE
R4465 T5340 T5339 arg1Of sequence,consensus
R4466 T5340 T5341 arg1Of sequence,(
R4467 T5342 T5341 arg2Of underlined,(
R4468 T5343 T5341 arg3Of ),(
R4469 T5344 T5345 arg1Of Specificity,was
R447 T556 T553 arg2Of and,in
R4470 T5344 T5346 arg2Of Specificity,determined
R4471 T5346 T5345 arg2Of determined,was
R4472 T5350 T5346 arg1Of assay,determined
R4473 T5350 T5347 arg2Of assay,by
R4474 T5350 T5348 arg1Of assay,a
R4475 T5350 T5349 arg1Of assay,competition
R4476 T5350 T5351 arg1Of assay,with
R4477 T5353 T5351 arg2Of addition,with
R4478 T5353 T5352 arg1Of addition,the
R4479 T5353 T5354 arg1Of addition,of
R448 T556 T554 arg1Of and,the
R4480 T5356 T5355 arg1Of molar,200
R4481 T5357 T5354 arg2Of excess,of
R4482 T5357 T5356 arg1Of excess,molar
R4483 T5357 T5358 arg1Of excess,of
R4484 T5361 T5359 arg1Of stranded,unlabeled
R4485 T5361 T5360 arg1Of stranded,double
R4486 T5363 T5358 arg2Of oligonucleotide,of
R4487 T5363 T5361 arg1Of oligonucleotide,stranded
R4488 T5363 T5362 arg1Of oligonucleotide,CREB
R4489 T5365 T5364 arg1Of extracts,Nuclear
R449 T556 T558 arg1Of and,of
R4490 T5365 T5366 arg1Of extracts,(
R4491 T5365 T5370 arg1Of extracts,were
R4492 T5365 T5371 arg2Of extracts,incubated
R4493 T5368 T5366 arg2Of μg,(
R4494 T5368 T5367 arg1Of μg,10
R4495 T5369 T5366 arg3Of ),(
R4496 T5371 T5370 arg2Of incubated,were
R4497 T5371 T5372 arg1Of incubated,with
R4498 T5373 T5374 arg1Of 5,nM
R4499 T5375 T5373 arg1Of NF-κB,5
R450 T557 T556 arg2Of absence,and
R4500 T5375 T5376 arg1Of NF-κB,or
R4501 T5376 T5372 arg2Of or,with
R4502 T5378 T5376 arg2Of probe,or
R4503 T5378 T5377 arg1Of probe,CREB
R4504 T5378 T5379 arg1Of probe,(
R4505 T5380 T5379 arg2Of NF-kB,(
R4506 T5381 T5379 arg3Of :,(
R4507 T5384 T5382 arg1Of buffer,1x
R4508 T5384 T5383 arg1Of buffer,binding
R4509 T5384 T5385 arg1Of buffer,","
R451 T559 T558 arg2Of Pentoxifylline,of
R4510 T5385 T5389 arg1Of ",",","
R4511 T5386 T5387 arg1Of 50,mM
R4512 T5388 T5385 arg2Of KCl,","
R4513 T5388 T5386 arg1Of KCl,50
R4514 T5389 T5393 arg1Of ",",","
R4515 T5390 T5391 arg1Of 1,mM
R4516 T5392 T5389 arg2Of EDTA,","
R4517 T5392 T5390 arg1Of EDTA,1
R4518 T5393 T5397 arg1Of ",",","
R4519 T5394 T5395 arg1Of 1,mM
R452 T559 T560 arg1Of Pentoxifylline,(
R4520 T5396 T5393 arg2Of DTT,","
R4521 T5396 T5394 arg1Of DTT,1
R4522 T5397 T5401 arg1Of ",",","
R4523 T5398 T5399 arg1Of 0.1,%
R4524 T5400 T5397 arg2Of NP40,","
R4525 T5400 T5398 arg1Of NP40,0.1
R4526 T5401 T5406 arg1Of ",",and
R4527 T5403 T5402 arg1Of %,10
R4528 T5404 T5401 arg2Of glycerol,","
R4529 T5404 T5403 arg1Of glycerol,%
R453 T561 T562 arg1Of PTX,;
R4530 T5406 T5405 arg1Of and,","
R4531 T5410 T5406 arg2Of dI-dC,and
R4532 T5410 T5407 arg1Of dI-dC,50
R4533 T5410 T5408 arg1Of dI-dC,ng/μl
R4534 T5410 T5409 arg1Of dI-dC,poly
R4535 T5410 T5411 arg1Of dI-dC,","
R4536 T5412 T5411 arg2Of CREB,","
R4537 T5412 T5413 arg1Of CREB,:
R4538 T5416 T5414 arg1Of buffer,1x
R4539 T5416 T5415 arg1Of buffer,binding
R454 T562 T560 arg2Of ;,(
R4540 T5416 T5417 arg1Of buffer,","
R4541 T5418 T5419 arg1Of 20,mM
R4542 T5420 T5417 arg2Of Tris,","
R4543 T5420 T5418 arg1Of Tris,20
R4544 T5420 T5421 arg1Of Tris,","
R4545 T5422 T5421 arg2Of pH,","
R4546 T5422 T5423 arg1Of pH,7.5
R4547 T5425 T5426 arg1Of 50,mM
R4548 T5427 T5425 arg1Of KCl,50
R4549 T5427 T5428 arg1Of KCl,","
R455 T564 T562 arg2Of mM,;
R4550 T5428 T5432 arg1Of ",",","
R4551 T5429 T5430 arg1Of 1,mM
R4552 T5431 T5428 arg2Of EDTA,","
R4553 T5431 T5429 arg1Of EDTA,1
R4554 T5433 T5434 arg1Of 1,mM
R4555 T5435 T5432 arg2Of DTT,","
R4556 T5435 T5433 arg1Of DTT,1
R4557 T5437 T5438 arg1Of 0.10,%
R4558 T5439 T5437 arg1Of NP40,0.10
R4559 T5439 T5440 arg1Of NP40,","
R456 T564 T563 arg1Of mM,20
R4560 T5440 T5444 arg1Of ",",","
R4561 T5441 T5442 arg1Of 6,%
R4562 T5443 T5440 arg2Of glycerol,","
R4563 T5443 T5441 arg1Of glycerol,6
R4564 T5444 T5448 arg1Of ",",and
R4565 T5445 T5446 arg1Of 0.1,mg/mL
R4566 T5447 T5444 arg2Of BSA,","
R4567 T5447 T5445 arg1Of BSA,0.1
R4568 T5452 T5448 arg2Of dI-dC,and
R4569 T5452 T5449 arg1Of dI-dC,50
R457 T565 T560 arg3Of ),(
R4570 T5452 T5450 arg1Of dI-dC,ng/μl
R4571 T5452 T5451 arg1Of dI-dC,poly
R4572 T5457 T5454 arg2Of electrophoresed,and
R4573 T5457 T5455 arg2Of electrophoresed,were
R4574 T5457 T5456 arg1Of electrophoresed,then
R4575 T5457 T5458 arg1Of electrophoresed,through
R4576 T5460 T5461 arg1Of 6,%
R4577 T5464 T5458 arg2Of gel,through
R4578 T5464 T5459 arg1Of gel,a
R4579 T5464 T5460 arg1Of gel,6
R458 T570 T566 arg2Of inhibitor,","
R4580 T5464 T5462 arg1Of gel,DNA
R4581 T5464 T5463 arg1Of gel,retardation
R4582 T5464 T5465 arg1Of gel,at
R4583 T5466 T5465 arg2Of 100V,at
R4584 T5466 T5467 arg1Of 100V,for
R4585 T5469 T5467 arg2Of minutes,for
R4586 T5469 T5468 arg1Of minutes,90
R4587 T5471 T5470 arg1Of gels,The
R4588 T5471 T5472 arg1Of gels,were
R4589 T5471 T5474 arg2Of gels,transferred
R459 T570 T567 arg1Of inhibitor,a
R4590 T5474 T5472 arg2Of transferred,were
R4591 T5474 T5473 arg1Of transferred,electrophoretically
R4592 T5474 T5475 arg1Of transferred,at
R4593 T5476 T5475 arg2Of 380mA,at
R4594 T5476 T5477 arg1Of 380mA,for
R4595 T5476 T5489 arg1Of 380mA,immediately
R4596 T5477 T5488 arg1Of for,and
R4597 T5479 T5477 arg2Of hour,for
R4598 T5479 T5478 arg1Of hour,1
R4599 T5479 T5480 arg1Of hour,on
R460 T570 T568 arg1Of inhibitor,nonspecific
R4600 T5479 T5482 arg1Of hour,to
R4601 T5481 T5480 arg2Of ice,on
R4602 T5485 T5484 arg1Of charged,positively
R4603 T5487 T5482 arg2Of membrane,to
R4604 T5487 T5483 arg1Of membrane,a
R4605 T5487 T5485 arg1Of membrane,charged
R4606 T5487 T5486 arg1Of membrane,nylon
R4607 T5489 T5488 arg2Of immediately,and
R4608 T5489 T5490 arg1Of immediately,cross-linked
R4609 T5490 T5491 arg1Of cross-linked,for
R461 T570 T569 arg1Of inhibitor,phosphodiesterase
R4610 T5493 T5491 arg2Of minutes,for
R4611 T5493 T5492 arg1Of minutes,15
R4612 T5493 T5494 arg1Of minutes,with
R4613 T5497 T5494 arg2Of transilluminator,with
R4614 T5497 T5495 arg1Of transilluminator,a
R4615 T5497 T5496 arg1Of transilluminator,UV
R4616 T5497 T5498 arg2Of transilluminator,equipped
R4617 T5498 T5499 arg1Of equipped,with
R4618 T5501 T5502 arg1Of 312,nm
R4619 T5503 T5499 arg2Of bulb,with
R462 T572 T571 arg1Of blotting,Western
R4620 T5503 T5500 arg1Of bulb,a
R4621 T5503 T5501 arg1Of bulb,312
R4622 T5506 T5504 arg1Of conjugate,Streptavidin-horseradish
R4623 T5506 T5505 arg1Of conjugate,peroxidase
R4624 T5506 T5507 arg1Of conjugate,and
R4625 T5507 T5512 arg1Of and,were
R4626 T5507 T5513 arg2Of and,used
R4627 T5511 T5507 arg2Of Substrate,and
R4628 T5511 T5508 arg1Of Substrate,the
R4629 T5511 T5509 arg1Of Substrate,LightShift
R463 T572 T573 arg1Of blotting,of
R4630 T5511 T5510 arg1Of Substrate,Chemiluminescent
R4631 T5513 T5512 arg2Of used,were
R4632 T5515 T5513 arg3Of detect,used
R4633 T5515 T5514 arg1Of detect,to
R4634 T5519 T5515 arg2Of DNA,detect
R4635 T5519 T5516 arg1Of DNA,the
R4636 T5519 T5517 arg1Of DNA,biotin
R4637 T5519 T5518 arg1Of DNA,end-labeled
R4638 T5522 T5520 arg1Of membranes,The
R4639 T5522 T5521 arg1Of membranes,nylon
R464 T572 T594 arg1Of blotting,was
R4640 T5522 T5523 arg1Of membranes,were
R4641 T5522 T5524 arg2Of membranes,exposed
R4642 T5524 T5523 arg2Of exposed,were
R4643 T5524 T5525 arg1Of exposed,to
R4644 T5524 T5528 arg1Of exposed,for
R4645 T5527 T5525 arg2Of film,to
R4646 T5527 T5526 arg1Of film,x-ray
R4647 T5530 T5528 arg2Of minutes,for
R4648 T5530 T5529 arg1Of minutes,1–3
R4649 T5530 T5531 arg1Of minutes,for
R465 T572 T595 arg2Of blotting,performed
R4650 T5532 T5531 arg2Of detection,for
R466 T576 T574 arg2Of I-κBα,phosphorylated
R467 T576 T575 arg1Of I-κBα,cytoplasmic
R468 T576 T577 arg1Of I-κBα,","
R469 T577 T585 arg1Of ",",and
R470 T580 T577 arg2Of p65,","
R471 T580 T578 arg1Of p65,nuclear
R472 T580 T579 arg1Of p65,factor-κB
R473 T580 T581 arg1Of p65,(
R474 T582 T581 arg2Of NF-κB,(
R475 T583 T581 arg3Of ),(
R476 T585 T573 arg2Of and,of
R477 T585 T584 arg1Of and,","
R478 T590 T585 arg2Of protein,and
R479 T590 T586 arg1Of protein,nuclear
R480 T590 T587 arg1Of protein,cAMP-response
R481 T590 T588 arg1Of protein,element
R482 T590 T589 arg1Of protein,binding
R483 T590 T591 arg1Of protein,(
R4831 T5799 T5800 arg1Of Role,of
R4832 T5799 T5802 arg1Of Role,on
R4833 T5801 T5800 arg2Of PKA,of
R4834 T5807 T5802 arg2Of production,on
R4835 T5807 T5803 arg1Of production,LPS-induced
R4836 T5807 T5804 arg1Of production,mononuclear
R4837 T5807 T5805 arg1Of production,cell
R4838 T5807 T5806 arg1Of production,TNF-α
R4839 T5809 T5808 arg1Of evaluate,To
R484 T592 T591 arg2Of CREB,(
R4840 T5809 T5842 arg1Of evaluate,was
R4841 T5809 T5843 arg2Of evaluate,utilized
R4842 T5811 T5810 arg1Of role,the
R4843 T5811 T5812 arg1Of role,of
R4844 T5811 T5814 arg1Of role,on
R4845 T5811 T5817 arg1Of role,in
R4846 T5811 T5820 arg1Of role,and
R4847 T5813 T5812 arg2Of PKA,of
R4848 T5816 T5814 arg2Of production,on
R4849 T5816 T5815 arg1Of production,TNF-α
R485 T593 T591 arg3Of ),(
R4850 T5819 T5817 arg2Of cells,in
R4851 T5819 T5818 arg1Of cells,mononuclear
R4852 T5820 T5809 arg2Of and,evaluate
R4853 T5822 T5820 arg2Of involvement,and
R4854 T5822 T5821 arg1Of involvement,its
R4855 T5822 T5823 arg1Of involvement,in
R4856 T5825 T5823 arg2Of attenuation,in
R4857 T5825 T5824 arg1Of attenuation,the
R4858 T5825 T5826 arg1Of attenuation,of
R4859 T5829 T5826 arg2Of production,of
R486 T595 T594 arg2Of performed,was
R4860 T5829 T5827 arg1Of production,LPS-induced
R4861 T5829 T5828 arg1Of production,TNF-α
R4862 T5829 T5830 arg2Of production,observed
R4863 T5830 T5831 arg1Of observed,following
R4864 T5833 T5831 arg2Of treatment,following
R4865 T5833 T5832 arg1Of treatment,PTX
R4866 T5833 T5834 arg1Of treatment,","
R4867 T5833 T5836 arg1Of treatment,","
R4868 T5835 T5834 arg2Of H89,","
R4869 T5840 T5836 arg2Of inhibitor,","
R487 T597 T596 arg1Of binding,DNA
R4870 T5840 T5837 arg1Of inhibitor,a
R4871 T5840 T5838 arg1Of inhibitor,specific
R4872 T5840 T5839 arg1Of inhibitor,PKA
R4873 T5843 T5841 arg1Of utilized,","
R4874 T5843 T5842 arg2Of utilized,was
R4875 T5846 T5844 arg2Of cells,Isolated
R4876 T5846 T5845 arg1Of cells,mononuclear
R4877 T5846 T5847 arg1Of cells,were
R4878 T5846 T5848 arg2Of cells,incubated
R4879 T5848 T5847 arg2Of incubated,were
R488 T597 T598 arg1Of binding,of
R4880 T5848 T5849 arg1Of incubated,according
R4881 T5850 T5849 arg2Of to,according
R4882 T5853 T5850 arg2Of groups,to
R4883 T5853 T5851 arg1Of groups,the
R4884 T5853 T5852 arg1Of groups,treatment
R4885 T5853 T5854 arg2Of groups,described
R4886 T5854 T5855 arg1Of described,above
R4887 T5854 T5856 arg1Of described,in
R4888 T5858 T5859 arg1Of presence,and
R4889 T5859 T5856 arg2Of and,in
R489 T597 T602 arg1Of binding,was
R4890 T5859 T5857 arg1Of and,the
R4891 T5859 T5861 arg1Of and,of
R4892 T5859 T5863 arg1Of and,with
R4893 T5860 T5859 arg2Of absence,and
R4894 T5862 T5861 arg2Of pretreatment,of
R4895 T5864 T5863 arg2Of H89,with
R4896 T5864 T5865 arg1Of H89,(
R4897 T5864 T5869 arg1Of H89,for
R4898 T5867 T5865 arg2Of μM,(
R4899 T5867 T5866 arg1Of μM,10
R490 T597 T603 arg2Of binding,verified
R4900 T5868 T5865 arg3Of ),(
R4901 T5871 T5869 arg2Of hour,for
R4902 T5871 T5870 arg1Of hour,1
R4903 T5871 T5872 arg1Of hour,at
R4904 T5873 T5872 arg2Of 37ºC,at
R4905 T5875 T5874 arg1Of dose,The
R4906 T5875 T5876 arg1Of dose,of
R4907 T5875 T5878 arg1Of dose,was
R4908 T5875 T5879 arg2Of dose,chosen
R4909 T5877 T5876 arg2Of H89,of
R491 T599 T600 arg1Of NF-κB,and
R4910 T5879 T5878 arg2Of chosen,was
R4911 T5879 T5880 modOf chosen,based
R4912 T5879 T5881 arg1Of chosen,on
R4913 T5883 T5881 arg2Of work,on
R4914 T5883 T5882 arg1Of work,previous
R4915 T5883 T5884 arg1Of work,which
R4916 T5883 T5885 arg1Of work,demonstrated
R4917 T5886 T5887 arg1Of specific,and
R4918 T5888 T5887 arg2Of complete,and
R4919 T5889 T5885 arg2Of inhibition,demonstrated
R492 T600 T598 arg2Of and,of
R4920 T5889 T5886 arg1Of inhibition,specific
R4921 T5889 T5888 arg1Of inhibition,complete
R4922 T5889 T5890 arg1Of inhibition,of
R4923 T5891 T5890 arg2Of PKA,of
R4924 T5894 T5892 arg2Of concentration.10,at
R4925 T5894 T5893 arg1Of concentration.10,this
R4926 T5894 T5895 arg1Of concentration.10,Since
R4927 T5897 T5896 arg1Of activity,the
R4928 T5897 T5898 arg1Of activity,of
R4929 T5897 T5901 arg1Of activity,is
R493 T601 T600 arg2Of CREB,and
R4930 T5897 T5903 arg1Of activity,specific
R4931 T5897 T5905 arg1Of activity,consistent
R4932 T5900 T5898 arg2Of inhibitor,of
R4933 T5900 T5899 arg1Of inhibitor,this
R4934 T5901 T5895 arg2Of is,Since
R4935 T5903 T5904 arg1Of specific,and
R4936 T5904 T5901 arg2Of and,is
R4937 T5904 T5902 arg1Of and,both
R4938 T5904 T5906 arg1Of and,at
R4939 T5905 T5904 arg2Of consistent,and
R494 T603 T602 arg2Of verified,was
R4940 T5909 T5906 arg2Of dose,at
R4941 T5909 T5907 arg1Of dose,this
R4942 T5909 T5908 arg2Of dose,specified
R4943 T5911 T5912 arg1Of we,did
R4944 T5911 T5914 arg1Of we,include
R4945 T5914 T5885 arg3Of include,demonstrated
R4946 T5914 T5892 arg1Of include,at
R4947 T5914 T5910 arg1Of include,","
R4948 T5914 T5912 arg2Of include,did
R4949 T5914 T5913 arg1Of include,not
R495 T608 T603 arg1Of assay,verified
R4950 T5915 T5914 arg2Of experiments,include
R4951 T5915 T5916 arg1Of experiments,with
R4952 T5919 T5916 arg2Of inhibitors,with
R4953 T5919 T5917 arg1Of inhibitors,additional
R4954 T5919 T5918 arg1Of inhibitors,PKA
R4955 T5919 T5920 arg1Of inhibitors,with
R4956 T5922 T5920 arg2Of set,with
R4957 T5922 T5921 arg1Of set,this
R4958 T5922 T5923 arg1Of set,of
R4959 T5924 T5923 arg2Of experiments,of
R496 T608 T604 arg2Of assay,by
R4960 T5927 T5925 arg1Of concentration,The
R4961 T5927 T5926 arg1Of concentration,TNF-α
R4962 T5927 T5928 arg1Of concentration,in
R4963 T5927 T5931 arg1Of concentration,was
R4964 T5927 T5932 arg2Of concentration,measured
R4965 T5930 T5928 arg2Of supernatant,in
R4966 T5930 T5929 arg1Of supernatant,the
R4967 T5932 T5931 arg2Of measured,was
R4968 T5932 T5933 arg1Of measured,quantitatively
R4969 T5935 T5932 arg1Of ELISA,measured
R497 T608 T605 arg1Of assay,electrophoretic
R4970 T5935 T5934 arg2Of ELISA,by
R4971 T5937 T5936 arg1Of results,The
R4972 T5937 T5938 arg1Of results,are
R4973 T5937 T5939 arg2Of results,expressed
R4974 T5939 T5938 arg2Of expressed,are
R4975 T5939 T5940 arg1Of expressed,in
R4976 T5941 T5940 arg2Of pg/mL,in
R498 T608 T606 arg1Of assay,mobility
R499 T608 T607 arg1Of assay,shift
R500 T610 T609 arg1Of levels,TNF-α
R501 T610 T611 arg1Of levels,were
R502 T610 T612 arg2Of levels,determined
R503 T612 T611 arg2Of determined,were
R504 T612 T613 arg1Of determined,in
R505 T612 T619 arg1Of determined,in
R506 T615 T613 arg2Of supernatant,in
R507 T615 T614 arg1Of supernatant,the
R508 T615 T616 arg1Of supernatant,of
R509 T618 T616 arg2Of cells,of
R510 T618 T617 arg2Of cells,stimulated
R5103 T6141 T6140 arg1Of Analysis,Statistical
R5104 T6144 T6142 arg1Of results,The
R5105 T6144 T6143 arg1Of results,experimental
R5106 T6144 T6145 arg2Of results,obtained
R5107 T6144 T6149 arg1Of results,were
R5108 T6144 T6150 arg2Of results,derived
R5109 T6145 T6146 arg1Of obtained,in
R511 T621 T622 arg1Of presence,and
R5110 T6148 T6146 arg2Of study,in
R5111 T6148 T6147 arg1Of study,this
R5112 T6150 T6149 arg2Of derived,were
R5113 T6150 T6151 arg1Of derived,from
R5114 T6154 T6151 arg2Of experiments,from
R5115 T6154 T6152 arg1Of experiments,four
R5116 T6154 T6153 arg1Of experiments,separate
R5117 T6154 T6155 arg1Of experiments,with
R5118 T6158 T6155 arg2Of donors,with
R5119 T6158 T6156 arg1Of donors,healthy
R512 T623 T622 arg2Of absence,and
R5120 T6158 T6157 arg1Of donors,volunteer
R5121 T6160 T6159 arg1Of assay,Each
R5122 T6160 T6161 arg1Of assay,was
R5123 T6160 T6162 arg2Of assay,performed
R5124 T6160 T6166 arg1Of assay,triplicate
R5125 T6162 T6161 arg2Of performed,was
R5126 T6162 T6163 arg1Of performed,in
R5127 T6162 T6165 arg1Of performed,or
R5128 T6164 T6163 arg2Of duplicate,in
R5129 T6166 T6165 arg2Of triplicate,or
R513 T627 T619 arg2Of inhibition,in
R5130 T6166 T6167 arg1Of triplicate,where
R5131 T6168 T6167 arg2Of appropriate,where
R5132 T6169 T6170 arg1Of Data,is
R5133 T6169 T6171 arg2Of Data,presented
R5134 T6171 T6170 arg2Of presented,is
R5135 T6171 T6172 arg1Of presented,as
R5136 T6176 T6172 arg2Of SEM,as
R5137 T6176 T6173 arg1Of SEM,the
R5138 T6176 T6174 arg1Of SEM,mean
R5139 T6176 T6175 arg1Of SEM,±
R514 T627 T620 arg1Of inhibition,the
R5140 T6178 T6177 arg1Of differences,Statistical
R5141 T6178 T6179 arg1Of differences,between
R5142 T6178 T6181 arg1Of differences,were
R5143 T6178 T6182 arg2Of differences,determined
R5144 T6180 T6179 arg2Of groups,between
R5145 T6182 T6181 arg2Of determined,were
R5146 T6185 T6182 arg1Of analysis,determined
R5147 T6185 T6183 arg2Of analysis,by
R5148 T6185 T6184 arg1Of analysis,one-way
R5149 T6185 T6186 arg1Of analysis,of
R515 T627 T621 arg1Of inhibition,presence
R5150 T6185 T6191 arg1Of analysis,with
R5151 T6187 T6186 arg2Of variance,of
R5152 T6187 T6188 arg1Of variance,(
R5153 T6189 T6188 arg2Of ANOVA,(
R5154 T6190 T6188 arg3Of ),(
R5155 T6194 T6191 arg2Of correction,with
R5156 T6194 T6192 arg1Of correction,a
R5157 T6194 T6193 arg1Of correction,Bonferroni
R5158 T6196 T6195 arg1Of significance,Statistical
R5159 T6196 T6197 arg1Of significance,was
R516 T627 T623 arg1Of inhibition,absence
R5160 T6196 T6198 arg2Of significance,defined
R5161 T6198 T6197 arg2Of defined,was
R5162 T6198 T6199 arg1Of defined,as
R5163 T6202 T6199 arg2Of 0.05,as
R5164 T6202 T6200 arg1Of 0.05,P
R5165 T6202 T6201 arg1Of 0.05,<
R517 T627 T624 arg1Of inhibition,Protein
R518 T627 T625 arg1Of inhibition,kinase
R519 T627 T626 arg1Of inhibition,A
R520 T627 T628 arg1Of inhibition,by
R521 T632 T628 arg2Of assay,by
R522 T632 T629 arg1Of assay,an
R523 T632 T630 arg1Of assay,enzyme-linked
R5237 T6294 T6293 arg1Of effects,The
R5238 T6294 T6295 arg1Of effects,of
R5239 T6294 T6297 arg1Of effects,on
R524 T632 T631 arg1Of assay,immunosorbent
R5240 T6296 T6295 arg2Of PTX,of
R5241 T6300 T6297 arg2Of production,on
R5242 T6300 T6298 arg1Of production,LPS-induced
R5243 T6300 T6299 arg1Of production,TNF-α
R5244 T6302 T6301 arg1Of determine,To
R5245 T6302 T6311 arg1Of determine,after
R5246 T6304 T6302 arg2Of duration,determine
R5247 T6304 T6303 arg1Of duration,the
R5248 T6304 T6305 arg1Of duration,of
R5249 T6304 T6308 arg1Of duration,on
R525 T632 T633 arg1Of assay,(
R5250 T6307 T6305 arg2Of inhibition,of
R5251 T6307 T6306 arg1Of inhibition,PDE
R5252 T6310 T6308 arg2Of production,on
R5253 T6310 T6309 arg1Of production,TNF-α
R5254 T6313 T6311 arg2Of stimulation,after
R5255 T6313 T6312 arg1Of stimulation,LPS
R5256 T6317 T6315 arg1Of studies,time
R5257 T6317 T6316 arg1Of studies,course
R5258 T6317 T6318 arg1Of studies,were
R5259 T6317 T6319 arg2Of studies,conducted
R526 T634 T633 arg2Of ELISA,(
R5260 T6319 T6301 modOf conducted,To
R5261 T6319 T6314 arg1Of conducted,","
R5262 T6319 T6318 arg2Of conducted,were
R5263 T6321 T6320 arg2Of accordance,In
R5264 T6321 T6322 arg1Of accordance,with
R5265 T6324 T6322 arg2Of work,with
R5266 T6324 T6323 arg1Of work,prior
R5267 T6326 T6327 arg1Of PTX,had
R5268 T6327 T6320 arg1Of had,In
R5269 T6327 T6325 arg1Of had,","
R527 T635 T633 arg3Of ),(
R5270 T6327 T6333 arg1Of had,on
R5271 T6329 T6330 arg1Of rapid,and
R5272 T6331 T6330 arg2Of sustained,and
R5273 T6332 T6327 arg2Of effect,had
R5274 T6332 T6328 arg1Of effect,a
R5275 T6332 T6329 arg1Of effect,rapid
R5276 T6332 T6331 arg1Of effect,sustained
R5277 T6335 T6333 arg2Of production,on
R5278 T6335 T6334 arg1Of production,TNF-α
R5279 T6335 T6337 arg1Of production,vitro
R528 T637 T638 arg1Of PTX,was
R5280 T6335 T6338 arg1Of production,(
R5281 T6337 T6336 arg1Of vitro,in
R5282 T6339 T6338 arg2Of Figure,(
R5283 T6339 T6340 arg1Of Figure,1
R5284 T6341 T6338 arg3Of ),(
R529 T637 T639 arg2Of PTX,demonstrated
R530 T637 T642 arg1Of PTX,reduce
R531 T639 T638 arg2Of demonstrated,was
R532 T642 T639 arg3Of reduce,demonstrated
R533 T642 T640 arg1Of reduce,to
R534 T642 T641 arg1Of reduce,significantly
R535 T645 T643 arg1Of phosphorylation,cytoplasmic
R536 T645 T644 arg1Of phosphorylation,I-κBα
R537 T645 T646 arg1Of phosphorylation,","
R538 T646 T651 arg1Of ",",and
R539 T649 T646 arg2Of phosphorylation,","
R540 T649 T647 arg1Of phosphorylation,nuclear
R541 T649 T648 arg1Of phosphorylation,p65
R542 T651 T642 arg2Of and,reduce
R543 T651 T650 arg1Of and,","
R544 T655 T651 arg2Of activity,and
R545 T655 T652 arg1Of activity,the
R546 T655 T653 arg1Of activity,DNA
R547 T655 T654 arg1Of activity,binding
R548 T655 T656 arg1Of activity,of
R549 T657 T656 arg2Of NF-κB,of
R550 T659 T658 arg2Of contrast,In
R551 T661 T663 arg1Of PTX,enhanced
R552 T663 T658 arg1Of enhanced,In
R553 T663 T660 arg1Of enhanced,","
R554 T663 T662 arg1Of enhanced,markedly
R555 T665 T666 arg1Of phosphorylation,and
R556 T666 T663 arg2Of and,enhanced
R557 T666 T664 arg1Of and,the
R5571 T6696 T6697 arg1Of PTX,decreases
R5572 T6700 T6697 arg2Of activation,decreases
R5573 T6700 T6698 arg1Of activation,LPS-induced
R5574 T6700 T6699 arg1Of activation,NF-κB
R5575 T6702 T6703 arg1Of phosphorylation,leads
R5576 T6703 T6701 arg2Of leads,Since
R5577 T6703 T6704 arg1Of leads,to
R5578 T6705 T6706 arg1Of ubiquitination,and
R5579 T6706 T6704 arg2Of and,to
R558 T666 T670 arg1Of and,of
R5580 T6706 T6708 arg1Of and,of
R5581 T6707 T6706 arg2Of degradation,and
R5582 T6709 T6710 arg1Of I-κBα,and
R5583 T6711 T6710 arg2Of subsequent,and
R5584 T6713 T6708 arg2Of translocation,of
R5585 T6713 T6709 arg1Of translocation,I-κBα
R5586 T6713 T6711 arg1Of translocation,subsequent
R5587 T6713 T6712 arg1Of translocation,nuclear
R5588 T6713 T6714 arg1Of translocation,of
R5589 T6715 T6714 arg2Of NF-κB,of
R559 T669 T666 arg2Of activity,and
R5590 T6717 T6719 arg1Of we,examined
R5591 T6719 T6701 arg1Of examined,Since
R5592 T6719 T6716 arg1Of examined,","
R5593 T6719 T6718 arg1Of examined,first
R5594 T6721 T6719 arg2Of effects,examined
R5595 T6721 T6720 arg1Of effects,the
R5596 T6721 T6722 arg1Of effects,of
R5597 T6721 T6724 arg1Of effects,on
R5598 T6723 T6722 arg2Of PTX,of
R5599 T6725 T6724 arg2Of I-κBα,on
R560 T669 T667 arg1Of activity,DNA
R5600 T6728 T6726 arg1Of phosphorylation,Cytoplasmic
R5601 T6728 T6727 arg1Of phosphorylation,I-κBα
R5602 T6728 T6729 arg1Of phosphorylation,was
R5603 T6728 T6731 arg2Of phosphorylation,increased
R5604 T6728 T6736 arg1Of phosphorylation,compared
R5605 T6731 T6729 arg2Of increased,was
R5606 T6731 T6730 arg1Of increased,markedly
R5607 T6731 T6732 arg1Of increased,following
R5608 T6731 T6735 arg1Of increased,when
R5609 T6734 T6732 arg2Of stimulation,following
R561 T669 T668 arg1Of activity,binding
R5610 T6734 T6733 arg1Of stimulation,LPS
R5611 T6736 T6735 arg2Of compared,when
R5612 T6736 T6737 arg1Of compared,to
R5613 T6738 T6737 arg2Of control,to
R5614 T6738 T6739 arg1Of control,(
R5615 T6742 T6739 arg2Of 0,(
R5616 T6742 T6740 arg1Of 0,100
R5617 T6742 T6741 arg1Of 0,±
R5618 T6742 T6743 arg1Of 0,vs.
R5619 T6742 T6747 arg1Of 0,;
R562 T671 T670 arg2Of CREB,of
R5620 T6744 T6745 arg1Of 20,±
R5621 T6745 T6743 arg2Of ±,vs.
R5622 T6746 T6745 arg2Of 18,±
R5623 T6748 T6747 arg2Of P,;
R5624 T6748 T6749 arg1Of P,<
R5625 T6748 T6750 arg1Of P,0.05
R5626 T6751 T6739 arg3Of ),(
R5627 T6753 T6752 arg1Of addition,The
R5628 T6753 T6754 arg1Of addition,of
R5629 T6753 T6757 arg1Of addition,downregulated
R563 T672 T674 arg2Of Cells,treated
R5630 T6755 T6754 arg2Of PTX,of
R5631 T6757 T6756 arg1Of downregulated,significantly
R5632 T6760 T6757 arg2Of phosphorylation,downregulated
R5633 T6760 T6758 arg1Of phosphorylation,LPS-induced
R5634 T6760 T6759 arg1Of phosphorylation,I-κBα
R5635 T6760 T6761 arg1Of phosphorylation,(
R5636 T6762 T6761 arg2Of P,(
R5637 T6762 T6763 arg1Of P,=
R5638 T6762 T6764 arg1Of P,0.02
R5639 T6762 T6765 arg1Of P,;
R564 T672 T679 arg1Of Cells,secreted
R5640 T6766 T6765 arg2Of Figure,;
R5641 T6766 T6767 arg1Of Figure,2
R5642 T6768 T6761 arg3Of ),(
R5643 T6772 T6769 arg2Of fashion,In
R5644 T6772 T6770 arg1Of fashion,a
R5645 T6772 T6771 arg1Of fashion,similar
R5646 T6777 T6774 arg1Of phosphorylation,nuclear
R5647 T6777 T6775 arg1Of phosphorylation,NF-κB
R5648 T6777 T6776 arg1Of phosphorylation,p65
R5649 T6777 T6778 arg1Of phosphorylation,was
R565 T674 T673 arg1Of treated,concomitantly
R5650 T6777 T6779 arg2Of phosphorylation,increased
R5651 T6779 T6769 arg1Of increased,In
R5652 T6779 T6773 arg1Of increased,","
R5653 T6779 T6778 arg2Of increased,was
R5654 T6779 T6780 arg1Of increased,following
R5655 T6782 T6780 arg2Of stimulation,following
R5656 T6782 T6781 arg1Of stimulation,LPS
R5657 T6782 T6783 arg1Of stimulation,(
R5658 T6786 T6783 arg2Of 0,(
R5659 T6786 T6784 arg1Of 0,100
R566 T674 T675 arg1Of treated,with
R5660 T6786 T6785 arg1Of 0,±
R5661 T6786 T6787 arg1Of 0,vs.
R5662 T6786 T6791 arg1Of 0,;
R5663 T6788 T6789 arg1Of 38,±
R5664 T6789 T6787 arg2Of ±,vs.
R5665 T6790 T6789 arg2Of 20,±
R5666 T6792 T6791 arg2Of P,;
R5667 T6792 T6793 arg1Of P,<
R5668 T6792 T6794 arg1Of P,0.01
R5669 T6795 T6783 arg3Of ),(
R567 T676 T677 arg1Of PTX,and
R5670 T6796 T6798 arg1Of PTX,decreased
R5671 T6798 T6797 arg1Of decreased,similarly
R5672 T6803 T6798 arg2Of phosphorylation,decreased
R5673 T6803 T6799 arg1Of phosphorylation,LPS-induced
R5674 T6803 T6800 arg1Of phosphorylation,NF-κB
R5675 T6803 T6801 arg1Of phosphorylation,p65
R5676 T6803 T6802 arg1Of phosphorylation,nuclear
R5677 T6803 T6804 arg1Of phosphorylation,","
R5678 T6806 T6804 arg2Of marker,","
R5679 T6806 T6805 arg1Of marker,a
R568 T677 T675 arg2Of and,with
R5680 T6806 T6807 arg1Of marker,of
R5681 T6809 T6808 arg1Of activation,NF-κB
R5682 T6809 T6810 arg1Of activation,and
R5683 T6810 T6807 arg2Of and,of
R5684 T6812 T6810 arg2Of translocation,and
R5685 T6812 T6811 arg1Of translocation,nuclear
R5686 T6812 T6813 arg1Of translocation,(
R5687 T6816 T6813 arg2Of 0,(
R5688 T6816 T6814 arg1Of 0,100
R5689 T6816 T6815 arg1Of 0,±
R569 T678 T677 arg2Of LPS,and
R5690 T6816 T6817 arg1Of 0,vs.
R5691 T6816 T6821 arg1Of 0,;
R5692 T6816 T6824 arg1Of 0,;
R5693 T6818 T6819 arg1Of 40,±
R5694 T6819 T6817 arg2Of ±,vs.
R5695 T6820 T6819 arg2Of 6,±
R5696 T6822 T6821 arg2Of P,;
R5697 T6822 T6823 arg1Of P,=0.03
R5698 T6826 T6824 arg2Of 3A,;
R5699 T6826 T6825 arg1Of 3A,Figure
R570 T681 T679 arg2Of levels,secreted
R5700 T6827 T6813 arg3Of ),(
R5701 T6828 T6829 arg1Of EMSAs,were
R5702 T6828 T6831 arg2Of EMSAs,performed
R5703 T6831 T6829 arg2Of performed,were
R5704 T6831 T6830 arg1Of performed,then
R5705 T6833 T6831 arg3Of verify,performed
R5706 T6833 T6832 arg1Of verify,to
R5707 T6836 T6834 arg1Of alterations,the
R5708 T6836 T6835 arg1Of alterations,PTX-induced
R5709 T6836 T6837 arg1Of alterations,in
R571 T681 T680 arg1Of levels,similar
R5710 T6836 T6840 arg1Of alterations,resulted
R5711 T6839 T6837 arg2Of phosphorylation,in
R5712 T6839 T6838 arg1Of phosphorylation,nuclear
R5713 T6840 T6833 arg2Of resulted,verify
R5714 T6840 T6841 arg1Of resulted,in
R5715 T6840 T6844 arg1Of resulted,on
R5716 T6843 T6841 arg2Of effects,in
R5717 T6843 T6842 arg1Of effects,similar
R5718 T6848 T6844 arg2Of activity,on
R5719 T6848 T6845 arg1Of activity,the
R572 T681 T682 arg1Of levels,of
R5720 T6848 T6846 arg1Of activity,DNA
R5721 T6848 T6847 arg1Of activity,binding
R5722 T6848 T6849 arg1Of activity,of
R5723 T6850 T6849 arg2Of NF-κB,of
R5724 T6852 T6851 arg1Of addition,The
R5725 T6852 T6853 arg1Of addition,of
R5726 T6852 T6855 arg1Of addition,to
R5727 T6852 T6859 arg1Of addition,resulted
R5728 T6854 T6853 arg2Of PTX,of
R5729 T6858 T6855 arg2Of cells,to
R573 T681 T684 arg1Of levels,in
R5730 T6858 T6856 arg1Of cells,LPS-stimulated
R5731 T6858 T6857 arg1Of cells,mononuclear
R5732 T6859 T6860 arg1Of resulted,in
R5733 T6859 T6867 arg1Of resulted,","
R5734 T6862 T6860 arg2Of downregulation,in
R5735 T6862 T6861 arg1Of downregulation,comparable
R5736 T6862 T6863 arg1Of downregulation,of
R5737 T6866 T6863 arg2Of activity,of
R5738 T6866 T6864 arg1Of activity,DNA
R5739 T6866 T6865 arg1Of activity,binding
R574 T683 T682 arg2Of TNF-α,of
R5740 T6868 T6859 arg2Of similar,resulted
R5741 T6868 T6869 arg1Of similar,to
R5742 T6872 T6869 arg2Of downregulation,to
R5743 T6872 T6870 arg1Of downregulation,the
R5744 T6872 T6871 arg2Of downregulation,observed
R5745 T6872 T6873 arg1Of downregulation,of
R5746 T6875 T6873 arg2Of phosphorylation,of
R5747 T6875 T6874 arg1Of phosphorylation,NF-κB
R5748 T6875 T6876 arg1Of phosphorylation,(
R5749 T6878 T6876 arg2Of 3B,(
R575 T686 T687 arg1Of presence,and
R5750 T6878 T6877 arg1Of 3B,Figure
R5751 T6879 T6876 arg3Of ),(
R576 T688 T687 arg2Of absence,and
R577 T692 T684 arg2Of inhibition,in
R578 T692 T685 arg1Of inhibition,the
R579 T692 T686 arg1Of inhibition,presence
R580 T692 T688 arg1Of inhibition,absence
R581 T692 T689 arg1Of inhibition,Protein
R582 T692 T690 arg1Of inhibition,kinase
R583 T692 T691 arg1Of inhibition,A
R584 T696 T694 arg1Of level,The
R585 T696 T695 arg2Of level,increased
R586 T696 T697 arg1Of level,of
R587 T696 T699 arg1Of level,that
R588 T696 T700 arg1Of level,results
R589 T696 T704 arg1Of level,affects
R590 T698 T697 arg2Of cAMP,of
R591 T700 T701 arg1Of results,from
R592 T703 T701 arg2Of inhibition,from
R593 T703 T702 arg1Of inhibition,phosphodiesterase
R594 T704 T709 arg1Of affects,","
R595 T704 T710 modOf affects,resulting
R596 T705 T706 arg1Of cytoplasmic,and
R597 T707 T706 arg2Of nuclear,and
R598 T708 T704 arg2Of events,affects
R599 T708 T705 arg1Of events,cytoplasmic
R600 T708 T707 arg1Of events,nuclear
R601 T710 T711 arg1Of resulting,in
R602 T710 T724 arg1Of resulting,through
R603 T713 T712 arg1Of attenuation,the
R604 T713 T714 arg1Of attenuation,of
R6043 T7258 T7259 arg1Of PTX,upregulates
R6044 T7259 T7264 arg1Of upregulates,after
R6045 T7261 T7262 arg1Of phosphorylation,and
R6046 T7262 T7259 arg2Of and,upregulates
R6047 T7262 T7260 arg1Of and,CREB
R6048 T7263 T7262 arg2Of activation,and
R6049 T7266 T7264 arg2Of stimulation,after
R605 T713 T716 arg1Of attenuation,and
R6050 T7266 T7265 arg1Of stimulation,LPS
R6051 T7267 T7268 arg1Of Phosphorylation,of
R6052 T7267 T7271 arg1Of Phosphorylation,was
R6053 T7267 T7272 arg2Of Phosphorylation,used
R6054 T7270 T7268 arg2Of CREB,of
R6055 T7270 T7269 arg1Of CREB,nuclear
R6056 T7272 T7271 arg2Of used,was
R6057 T7272 T7273 arg1Of used,as
R6058 T7275 T7273 arg2Of marker,as
R6059 T7275 T7274 arg1Of marker,a
R606 T715 T714 arg2Of NF-κB,of
R6060 T7275 T7276 arg1Of marker,for
R6061 T7278 T7276 arg2Of activation,for
R6062 T7278 T7277 arg1Of activation,CREB
R6063 T7280 T7279 arg1Of stimulation,LPS
R6064 T7280 T7281 arg1Of stimulation,caused
R6065 T7280 T7289 arg1Of stimulation,compared
R6066 T7281 T7288 arg1Of caused,when
R6067 T7284 T7281 arg2Of increase,caused
R6068 T7284 T7282 arg1Of increase,a
R6069 T7284 T7283 arg1Of increase,negligible
R607 T716 T711 arg2Of and,in
R6070 T7284 T7285 arg1Of increase,in
R6071 T7287 T7285 arg2Of phosphorylation,in
R6072 T7287 T7286 arg1Of phosphorylation,CREB
R6073 T7289 T7288 arg2Of compared,when
R6074 T7289 T7290 arg1Of compared,to
R6075 T7291 T7290 arg2Of control,to
R6076 T7291 T7292 arg1Of control,(
R6077 T7294 T7292 arg2Of 4A,(
R6078 T7294 T7293 arg1Of 4A,Figure
R6079 T7295 T7292 arg3Of ),(
R608 T718 T716 arg2Of activation,and
R6080 T7296 T7297 arg1Of PTX,alone
R6081 T7296 T7298 arg1Of PTX,caused
R6082 T7301 T7298 arg2Of increase,caused
R6083 T7301 T7299 arg1Of increase,a
R6084 T7301 T7300 arg1Of increase,marked
R6085 T7301 T7302 arg1Of increase,in
R6086 T7304 T7302 arg2Of phosphorylation,in
R6087 T7304 T7303 arg1Of phosphorylation,CREB
R6088 T7304 T7305 arg1Of phosphorylation,(
R6089 T7306 T7305 arg2Of P,(
R609 T718 T717 arg1Of activation,the
R6090 T7306 T7307 arg1Of P,<
R6091 T7306 T7309 arg1Of P,vs.
R6092 T7307 T7308 arg1Of <,0.01
R6093 T7310 T7309 arg2Of HBSS,vs.
R6094 T7311 T7305 arg3Of ),(
R6095 T7313 T7314 arg1Of LPS,and
R6096 T7314 T7317 arg1Of and,occurred
R6097 T7316 T7314 arg2Of exposure,and
R6098 T7316 T7315 arg1Of exposure,PTX
R6099 T7317 T7312 arg2Of occurred,When
R610 T718 T719 arg1Of activation,of
R6100 T7317 T7318 arg1Of occurred,simultaneously
R6101 T7321 T7320 arg1Of phosphorylation,CREB
R6102 T7321 T7322 arg1Of phosphorylation,was
R6103 T7321 T7324 arg1Of phosphorylation,higher
R6104 T7322 T7312 arg1Of was,When
R6105 T7322 T7319 arg1Of was,","
R6106 T7322 T7330 arg1Of was,(
R6107 T7324 T7322 arg2Of higher,was
R6108 T7324 T7323 arg1Of higher,significantly
R6109 T7324 T7325 arg1Of higher,than
R611 T723 T719 arg2Of binding,of
R6110 T7326 T7325 arg2Of with,than
R6111 T7328 T7326 arg2Of stimulation,with
R6112 T7328 T7327 arg1Of stimulation,LPS
R6113 T7328 T7329 arg1Of stimulation,alone
R6114 T7331 T7332 arg1Of 543,±
R6115 T7332 T7330 arg2Of ±,(
R6116 T7332 T7334 arg1Of ±,vs.
R6117 T7332 T7338 arg1Of ±,;
R6118 T7333 T7332 arg2Of 92,±
R6119 T7337 T7334 arg2Of 0,vs.
R612 T723 T720 arg1Of binding,CREB
R6120 T7337 T7335 arg1Of 0,100
R6121 T7337 T7336 arg1Of 0,±
R6122 T7339 T7338 arg2Of P,;
R6123 T7339 T7340 arg1Of P,<
R6124 T7339 T7341 arg1Of P,0.01
R6125 T7342 T7330 arg3Of ),(
R6126 T7344 T7343 arg2Of addition,In
R6127 T7347 T7346 arg1Of amount,the
R6128 T7347 T7348 arg1Of amount,of
R6129 T7347 T7358 arg1Of amount,was
R613 T723 T721 arg1Of binding,transcriptional
R6130 T7347 T7359 arg1Of amount,less
R6131 T7350 T7348 arg2Of phosphorylation,of
R6132 T7350 T7349 arg1Of phosphorylation,CREB
R6133 T7350 T7351 arg2Of phosphorylation,seen
R6134 T7351 T7352 arg1Of seen,with
R6135 T7354 T7353 arg1Of LPS,concomitant
R6136 T7354 T7355 arg1Of LPS,and
R6137 T7355 T7352 arg2Of and,with
R6138 T7357 T7355 arg2Of treatment,and
R6139 T7357 T7356 arg1Of treatment,PTX
R614 T723 T722 arg1Of binding,DNA
R6140 T7358 T7343 arg1Of was,In
R6141 T7358 T7345 arg1Of was,","
R6142 T7358 T7366 arg1Of was,","
R6143 T7358 T7367 arg1Of was,although
R6144 T7359 T7358 arg2Of less,was
R6145 T7359 T7360 arg1Of less,than
R6146 T7361 T7360 arg2Of that,than
R6147 T7361 T7362 arg2Of that,seen
R6148 T7362 T7363 arg1Of seen,with
R6149 T7364 T7363 arg2Of PTX,with
R615 T725 T724 arg2Of pathways,through
R6150 T7364 T7365 arg1Of PTX,alone
R6151 T7369 T7368 arg1Of difference,this
R6152 T7369 T7370 arg1Of difference,was
R6153 T7369 T7373 arg1Of difference,significant
R6154 T7370 T7367 arg2Of was,although
R6155 T7370 T7371 arg1Of was,not
R6156 T7370 T7372 arg1Of was,statistically
R6157 T7373 T7370 arg2Of significant,was
R6158 T7373 T7374 arg1Of significant,(
R6159 T7375 T7374 arg2Of P,(
R616 T725 T726 arg1Of pathways,that
R6160 T7375 T7376 arg1Of P,=
R6161 T7375 T7377 arg1Of P,0.08
R6162 T7378 T7374 arg3Of ),(
R6163 T7380 T7379 arg1Of determine,To
R6164 T7383 T7382 arg1Of binding,CREB-DNA
R6165 T7383 T7384 arg1Of binding,was
R6166 T7383 T7385 arg2Of binding,affected
R6167 T7385 T7380 arg2Of affected,determine
R6168 T7385 T7381 arg1Of affected,if
R6169 T7385 T7384 arg2Of affected,was
R617 T725 T727 arg1Of pathways,are
R6170 T7385 T7388 arg1Of affected,in
R6171 T7387 T7385 arg1Of PTX,affected
R6172 T7387 T7386 arg2Of PTX,by
R6173 T7390 T7388 arg2Of manner,in
R6174 T7390 T7389 arg1Of manner,a
R6175 T7390 T7391 arg1Of manner,similar
R6176 T7391 T7392 arg1Of similar,to
R6177 T7394 T7392 arg2Of phosphorylation,to
R6178 T7394 T7393 arg1Of phosphorylation,CREB
R6179 T7397 T7396 arg1Of EMSA,an
R618 T725 T731 arg1Of pathways,A-independent
R6180 T7397 T7398 arg1Of EMSA,was
R6181 T7397 T7399 arg2Of EMSA,performed
R6182 T7399 T7379 modOf performed,To
R6183 T7399 T7395 arg1Of performed,","
R6184 T7399 T7398 arg2Of performed,was
R6185 T7400 T7401 arg1Of Exposure,of
R6186 T7400 T7404 arg1Of Exposure,to
R6187 T7400 T7407 arg1Of Exposure,increased
R6188 T7403 T7401 arg2Of cells,of
R6189 T7403 T7402 arg1Of cells,LPS-stimulated
R619 T727 T728 arg1Of are,partially
R6190 T7405 T7404 arg2Of PTX,to
R6191 T7407 T7406 arg1Of increased,similarly
R6192 T7407 T7410 arg1Of increased,compared
R6193 T7409 T7407 arg2Of DNA-binding,increased
R6194 T7409 T7408 arg1Of DNA-binding,CREB
R6195 T7411 T7410 arg2Of to,compared
R6196 T7412 T7411 arg2Of LPS,to
R6197 T7412 T7413 arg1Of LPS,alone
R6198 T7412 T7414 arg1Of LPS,(
R6199 T7416 T7414 arg2Of 4B,(
R620 T731 T727 arg2Of A-independent,are
R6200 T7416 T7415 arg1Of 4B,Figure
R6201 T7417 T7414 arg3Of ),(
R621 T731 T729 arg1Of A-independent,Protein
R622 T731 T730 arg1Of A-independent,kinase
R623 T735 T733 arg1Of inhibition,PTX-mediated
R624 T735 T734 arg1Of inhibition,phosphodiesterase
R625 T735 T736 arg1Of inhibition,occurs
R626 T735 T745 arg1Of inhibition,may
R627 T735 T746 arg1Of inhibition,serve
R628 T736 T737 arg1Of occurs,partially
R629 T736 T738 arg1Of occurs,through
R630 T736 T744 arg1Of occurs,and
R631 T743 T738 arg2Of pathway,through
R632 T743 T739 arg1Of pathway,a
R633 T743 T740 arg1Of pathway,Protein
R634 T743 T741 arg1Of pathway,kinase
R635 T743 T742 arg1Of pathway,A-independent
R636 T746 T744 arg2Of serve,and
R637 T746 T745 arg2Of serve,may
R638 T746 T747 arg1Of serve,as
R639 T750 T747 arg2Of tool,as
R640 T750 T748 arg1Of tool,a
R641 T750 T749 arg1Of tool,useful
R6417 T7755 T7756 arg1Of Effect,of
R6418 T7755 T7758 arg1Of Effect,on
R6419 T7757 T7756 arg2Of PTX,of
R642 T750 T751 arg1Of tool,in
R6420 T7760 T7758 arg2Of production,on
R6421 T7760 T7759 arg1Of production,TNF-α
R6422 T7760 T7761 arg1Of production,in
R6423 T7763 T7761 arg2Of presence,in
R6424 T7763 T7762 arg1Of presence,the
R6425 T7763 T7764 arg1Of presence,of
R6426 T7766 T7764 arg2Of inhibition,of
R6427 T7766 T7765 arg1Of inhibition,PKA
R6428 T7768 T7767 arg1Of role,The
R6429 T7768 T7769 arg1Of role,of
R643 T753 T751 arg2Of attenuation,in
R6430 T7768 T7771 arg1Of role,in
R6431 T7768 T7777 arg1Of role,in
R6432 T7768 T7781 arg1Of role,was
R6433 T7768 T7782 arg2Of role,assessed
R6434 T7770 T7769 arg2Of PKA,of
R6435 T7773 T7771 arg2Of downregulation,in
R6436 T7773 T7772 arg1Of downregulation,PTX-induced
R6437 T7773 T7774 arg1Of downregulation,of
R6438 T7776 T7774 arg2Of production,of
R6439 T7776 T7775 arg1Of production,TNF-α
R644 T753 T752 arg1Of attenuation,the
R6440 T7780 T7777 arg2Of cells,in
R6441 T7780 T7778 arg1Of cells,LPS-stimulated
R6442 T7780 T7779 arg1Of cells,mononuclear
R6443 T7782 T7781 arg2Of assessed,was
R6444 T7782 T7783 arg1Of assessed,by
R6445 T7784 T7783 arg2Of treating,by
R6446 T7786 T7784 arg2Of cells,treating
R6447 T7786 T7785 arg1Of cells,mononuclear
R6448 T7786 T7787 arg1Of cells,with
R6449 T7786 T7793 arg1Of cells,","
R645 T753 T754 arg1Of attenuation,of
R6450 T7786 T7794 arg1Of cells,prior
R6451 T7788 T7787 arg2Of H89,with
R6452 T7788 T7789 arg1Of H89,","
R6453 T7792 T7789 arg2Of inhibitor,","
R6454 T7792 T7790 arg1Of inhibitor,a
R6455 T7792 T7791 arg1Of inhibitor,PKA
R6456 T7794 T7795 arg1Of prior,to
R6457 T7796 T7797 arg1Of LPS,and
R6458 T7797 T7795 arg2Of and,to
R6459 T7799 T7797 arg2Of exposure,and
R646 T756 T754 arg2Of inflammation,of
R6460 T7799 T7798 arg1Of exposure,PTX
R6461 T7802 T7800 arg1Of PTX,The
R6462 T7802 T7801 arg1Of PTX,addition
R6463 T7802 T7803 arg1Of PTX,to
R6464 T7802 T7806 arg1Of PTX,resulted
R6465 T7805 T7803 arg2Of cells,to
R6466 T7805 T7804 arg1Of cells,LPS-stimulated
R6467 T7806 T7807 arg1Of resulted,in
R6468 T7809 T7807 arg2Of reduction,in
R6469 T7809 T7808 arg1Of reduction,a
R647 T756 T755 arg1Of inflammation,LPS-induced
R6470 T7809 T7810 arg1Of reduction,in
R6471 T7809 T7812 arg1Of reduction,","
R6472 T7809 T7813 arg1Of reduction,similar
R6473 T7809 T7821 arg1Of reduction,(
R6474 T7811 T7810 arg2Of TNF-α,in
R6475 T7813 T7814 arg1Of similar,to
R6476 T7815 T7814 arg2Of that,to
R6477 T7815 T7816 arg2Of that,observed
R6478 T7816 T7817 arg1Of observed,in
R6479 T7820 T7817 arg2Of experiments,in
R6480 T7820 T7818 arg1Of experiments,our
R6481 T7820 T7819 arg1Of experiments,previous
R6482 T7823 T7822 arg1Of pg/mL,529
R6483 T7824 T7823 arg1Of ±,pg/mL
R6484 T7827 T7826 arg1Of 37,vs.
R6485 T7829 T7821 arg2Of ±,(
R6486 T7829 T7824 arg1Of ±,±
R6487 T7829 T7825 arg1Of ±,112
R6488 T7829 T7827 arg1Of ±,37
R6489 T7829 T7828 arg1Of ±,pg/mL
R6490 T7829 T7830 arg1Of ±,10
R6491 T7829 T7831 arg1Of ±,;
R6492 T7832 T7831 arg2Of P,;
R6493 T7832 T7833 arg1Of P,<
R6494 T7832 T7834 arg1Of P,0.01
R6495 T7835 T7821 arg3Of ),(
R6496 T7836 T7837 arg1Of Pre-incubation,of
R6497 T7836 T7839 arg1Of Pre-incubation,with
R6498 T7836 T7847 arg1Of Pre-incubation,did
R6499 T7836 T7849 arg1Of Pre-incubation,result
R6500 T7838 T7837 arg2Of cells,of
R6501 T7840 T7839 arg2Of H89,with
R6502 T7840 T7841 arg1Of H89,prior
R6503 T7841 T7842 arg1Of prior,to
R6504 T7843 T7844 arg1Of LPS,and
R6505 T7845 T7844 arg2Of PTX,and
R6506 T7846 T7842 arg2Of exposure,to
R6507 T7846 T7843 arg1Of exposure,LPS
R6508 T7846 T7845 arg1Of exposure,PTX
R6509 T7849 T7847 arg2Of result,did
R6510 T7849 T7848 arg1Of result,not
R6511 T7849 T7850 arg1Of result,in
R6512 T7853 T7850 arg2Of modulation,in
R6513 T7853 T7851 arg1Of modulation,any
R6514 T7853 T7852 arg1Of modulation,significant
R6515 T7853 T7854 arg1Of modulation,of
R6516 T7853 T7858 arg1Of modulation,compared
R6517 T7853 T7861 arg2Of modulation,demonstrated
R6518 T7856 T7854 arg2Of production,of
R6519 T7856 T7855 arg1Of production,TNF-α
R6520 T7858 T7857 arg2Of compared,when
R6521 T7858 T7859 arg1Of compared,to
R6522 T7860 T7859 arg2Of that,to
R6523 T7861 T7857 arg1Of demonstrated,when
R6524 T7861 T7862 arg1Of demonstrated,with
R6525 T7863 T7862 arg2Of PTX,with
R6526 T7863 T7864 arg1Of PTX,alone
R6527 T7864 T7865 arg1Of alone,(
R6528 T7866 T7865 arg2Of P,(
R6529 T7866 T7867 arg1Of P,=
R6530 T7866 T7868 arg1Of P,0.2
R6531 T7866 T7869 arg1Of P,;
R6532 T7870 T7869 arg2Of Figure,;
R6533 T7870 T7871 arg1Of Figure,5
R6534 T7872 T7865 arg3Of ),(
R6535 T7874 T7873 arg1Of results,These
R6536 T7874 T7875 arg1Of results,suggest
R6537 T7877 T7878 arg1Of downregulation,of
R6538 T7877 T7883 arg1Of downregulation,in
R6539 T7877 T7887 arg1Of downregulation,is
R6540 T7880 T7878 arg2Of production,of
R6541 T7880 T7879 arg1Of production,TNF-α
R6542 T7880 T7881 arg1Of production,by
R6543 T7882 T7881 arg2Of PTX,by
R6544 T7886 T7883 arg2Of cells,in
R6545 T7886 T7884 arg1Of cells,LPS-stimulated
R6546 T7886 T7885 arg1Of cells,mononuclear
R6547 T7887 T7875 arg2Of is,suggest
R6548 T7887 T7876 arg1Of is,that
R6549 T7887 T7888 arg1Of is,","
R6550 T7887 T7891 arg1Of is,in
R6551 T7887 T7893 arg1Of is,","
R6552 T7890 T7889 arg1Of least,at
R6553 T7891 T7890 arg1Of in,least
R6554 T7892 T7891 arg2Of part,in
R6555 T7894 T7887 arg2Of PKA-independent,is