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PMC:1942070 / 4542-6816 JSONTXT 20 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T2289 10-12 IN denotes of
T2290 13-18 NN denotes HSP27
T2291 19-34 NN denotes phosphorylation
T2292 35-37 IN denotes in
T2293 38-42 NN denotes DT40
T2294 43-44 NN denotes B
T2295 45-50 NN denotes cells
T2296 51-58 VB denotes lacking
T2297 59-69 NN denotes expression
T2298 70-72 IN denotes of
T2299 73-76 NN denotes PKD
T2300 77-83 NN denotes family
T2301 84-91 NN denotes kinases
T2302 92-96 NN denotes DT40
T2303 97-98 NN denotes B
T2304 99-104 NN denotes cells
T2305 105-112 VB denotes express
T2306 113-116 CD denotes two
T2307 117-120 NN denotes PKD
T2308 121-129 NN denotes isoforms
T2309 129-130 -COMMA- denotes ,
T2310 131-135 NN denotes PKD1
T2311 136-139 CC denotes and
T2312 140-144 NN denotes PKD3
T2313 144-145 -COMMA- denotes ,
T2314 146-149 CC denotes and
T2315 150-152 IN denotes as
T2316 153-163 RB denotes previously
T2317 164-173 VB denotes described
T2318 174-176 PRP denotes we
T2319 177-181 VB denotes have
T2320 182-190 RB denotes recently
T2321 191-200 VB denotes generated
T2322 201-205 NN denotes DT40
T2323 206-207 NN denotes B
T2324 208-212 NN denotes cell
T2325 213-218 NN denotes lines
T2326 219-223 WDT denotes that
T2327 224-228 VB denotes lack
T2328 229-239 NN denotes expression
T2329 240-242 IN denotes of
T2330 243-249 CC denotes either
T2331 250-254 NN denotes PKD1
T2332 255-257 CC denotes or
T2333 258-262 NN denotes PKD3
T2334 263-265 CC denotes or
T2335 266-270 DT denotes both
T2336 271-278 NN denotes enzymes
T2337 279-280 -LRB- denotes [
T2338 280-281 CD denotes 1
T2339 281-282 -RRB- denotes ]
T2340 284-286 IN denotes In
T2341 287-297 VB denotes generating
T2342 298-301 DT denotes the
T2343 302-308 JJ denotes double
T2344 309-317 NN denotes knockout
T2345 318-322 NN denotes cell
T2346 323-328 NN denotes lines
T2347 329-331 PRP denotes we
T2348 332-340 VB denotes targeted
T2349 341-344 DT denotes the
T2350 345-349 NN denotes PKD1
T2351 350-354 NN denotes loci
T2352 355-357 IN denotes in
T2353 358-359 DT denotes a
T2354 360-367 NN denotes PKD3−/−
T2355 368-372 NN denotes cell
T2356 373-377 NN denotes line
T2357 378-382 WDT denotes that
T2358 383-392 VB denotes expressed
T2359 393-394 DT denotes a
T2360 395-404 NN denotes Flag-PKD3
T2361 405-414 NN denotes transgene
T2362 415-420 IN denotes under
T2363 421-424 DT denotes the
T2364 425-432 NN denotes control
T2365 433-435 IN denotes of
T2366 436-437 DT denotes a
T2367 438-459 JJ denotes doxycycline-inducible
T2368 460-468 NN denotes promoter
T2369 470-475 RB denotes Hence
T2370 475-476 -COMMA- denotes ,
T2371 477-479 IN denotes in
T2372 480-483 DT denotes the
T2373 484-492 NN denotes presence
T2374 493-495 IN denotes of
T2375 496-507 NN denotes doxycycline
T2376 507-508 -COMMA- denotes ,
T2377 509-518 NN denotes Flag-PKD3
T2378 519-529 NN denotes expression
T2379 530-532 IN denotes in
T2380 533-539 NN denotes PKD1/3
T2381 540-546 JJ denotes double
T2382 547-555 JJ denotes knockout
T2383 556-561 NN denotes cells
T2384 562-564 VB denotes is
T2385 565-575 JJ denotes comparable
T2386 576-578 TO denotes to
T2387 579-589 JJ denotes endogenous
T2388 590-594 NN denotes PKD3
T2389 595-602 JJ denotes present
T2390 603-605 IN denotes in
T2391 606-615 JJ denotes wild-type
T2392 616-620 NN denotes DT40
T2393 621-626 NN denotes cells
T2394 627-630 CC denotes and
T2395 631-638 NN denotes removal
T2396 639-641 IN denotes of
T2397 642-653 NN denotes doxycycline
T2398 654-658 IN denotes from
T2399 659-662 DT denotes the
T2400 663-670 NN denotes culture
T2401 671-676 NN denotes media
T2402 677-680 IN denotes for
T2403 681-682 CD denotes 5
T2404 683-687 NN denotes days
T2405 688-695 VB denotes results
T2406 696-698 IN denotes in
T2407 699-700 DT denotes a
T2408 701-711 RB denotes completely
T2409 712-716 JJ denotes null
T2410 717-720 NN denotes PKD
T2411 721-730 NN denotes phenotype
T2412 731-732 -LRB- denotes (
T2413 732-736 NN denotes Fig.
T2414 737-739 NN denotes 1A
T2415 739-740 -RRB- denotes )
T2416 742-752 RB denotes Previously
T2417 752-753 -COMMA- denotes ,
T2418 754-756 PRP denotes we
T2419 757-761 VB denotes have
T2420 762-774 VB denotes demonstrated
T2421 775-779 IN denotes that
T2422 780-795 NN denotes phosphorylation
T2423 796-799 CC denotes and
T2424 800-807 JJ denotes nuclear
T2425 808-817 NN denotes exclusion
T2426 818-820 IN denotes of
T2427 821-826 NN denotes class
T2428 827-829 CD denotes II
T2429 830-837 NN denotes histone
T2430 838-850 NN denotes deacetylases
T2431 851-852 -LRB- denotes (
T2432 852-857 NN denotes HDACs
T2433 857-858 -RRB- denotes )
T2434 859-865 IN denotes during
T2435 866-869 NN denotes BCR
T2436 870-880 NN denotes engagement
T2437 881-883 VB denotes is
T2438 884-893 JJ denotes defective
T2439 894-896 IN denotes in
T2440 897-906 NN denotes PKD1/3−/−
T2441 907-908 NN denotes B
T2442 909-914 NN denotes cells
T2443 915-918 CC denotes and
T2444 919-922 MD denotes can
T2445 923-931 VB denotes restored
T2446 932-936 IN denotes upon
T2447 937-950 NN denotes re-expression
T2448 951-953 IN denotes of
T2449 954-955 DT denotes a
T2450 956-962 JJ denotes single
T2451 963-966 NN denotes PKD
T2452 967-974 NN denotes isoform
T2453 975-976 -LRB- denotes [
T2454 976-977 CD denotes 1
T2455 977-978 -RRB- denotes ]
T2456 980-983 DT denotes The
T2457 984-989 JJ denotes small
T2458 990-994 NN denotes heat
T2459 995-1000 NN denotes shock
T2460 1001-1008 NN denotes protein
T2461 1009-1014 NN denotes HSP27
T2462 1015-1018 VB denotes has
T2463 1019-1027 RB denotes recently
T2464 1028-1032 VB denotes been
T2465 1033-1041 VB denotes proposed
T2466 1042-1044 IN denotes as
T2467 1045-1046 DT denotes a
T2468 1047-1051 NN denotes PKD1
T2469 1052-1061 NN denotes substrate
T2470 1062-1063 -LRB- denotes [
T2471 1063-1065 CD denotes 24
T2472 1065-1066 -RRB- denotes ]
T2473 1067-1070 CC denotes and
T2474 1071-1073 PRP denotes we
T2475 1074-1085 RB denotes accordingly
T2476 1086-1094 VB denotes assessed
T2477 1095-1102 IN denotes whether
T2478 1103-1111 JJ denotes PKD-null
T2479 1112-1116 NN denotes DT40
T2480 1117-1122 NN denotes cells
T2481 1123-1127 VB denotes have
T2482 1128-1137 JJ denotes defective
T2483 1138-1153 NN denotes phosphorylation
T2484 1154-1156 IN denotes of
T2485 1157-1162 NN denotes HSP27
T2486 1163-1165 IN denotes on
T2487 1166-1172 NN denotes serine
T2488 1173-1175 CD denotes 82
T2489 1175-1176 -COMMA- denotes ,
T2490 1177-1180 DT denotes the
T2491 1181-1189 VB denotes proposed
T2492 1190-1194 NN denotes PKD1
T2493 1195-1204 NN denotes substrate
T2494 1205-1213 NN denotes sequence
T2495 1215-1217 PRP denotes We
T2496 1218-1227 RB denotes initially
T2497 1228-1240 VB denotes investigated
T2498 1241-1244 DT denotes the
T2499 1245-1255 NN denotes regulation
T2500 1256-1258 IN denotes of
T2501 1259-1264 NN denotes HSP27
T2502 1265-1280 NN denotes phosphorylation
T2503 1281-1283 IN denotes in
T2504 1284-1290 JJ denotes single
T2505 1291-1299 NN denotes knockout
T2506 1300-1304 NN denotes DT40
T2507 1305-1306 NN denotes B
T2508 1307-1312 NN denotes cells
T2509 1313-1320 VB denotes lacking
T2510 1321-1327 CC denotes either
T2511 1328-1332 NN denotes PKD1
T2512 1333-1335 CC denotes or
T2513 1336-1340 NN denotes PKD3
T2514 1342-1344 IN denotes As
T2515 1345-1350 VB denotes shown
T2516 1351-1353 IN denotes in
T2517 1354-1358 NNP denotes Fig.
T2518 1359-1361 NN denotes 1B
T2519 1361-1362 -COMMA- denotes ,
T2520 1363-1373 NN denotes activation
T2521 1374-1376 IN denotes of
T2522 1377-1380 DT denotes the
T2523 1381-1384 NN denotes BCR
T2524 1385-1387 CC denotes or
T2525 1388-1397 NN denotes treatment
T2526 1398-1402 IN denotes with
T2527 1403-1406 DT denotes the
T2528 1407-1418 JJ denotes DAG-mimetic
T2529 1419-1423 NN denotes PdBu
T2530 1424-1433 VB denotes increased
T2531 1434-1437 DT denotes the
T2532 1438-1444 NN denotes levels
T2533 1445-1447 IN denotes of
T2534 1448-1453 NN denotes HSP27
T2535 1454-1469 NN denotes phosphorylation
T2536 1470-1472 IN denotes at
T2537 1473-1476 NN denotes S82
T2538 1477-1479 IN denotes in
T2539 1480-1489 JJ denotes wild-type
T2540 1490-1494 NN denotes DT40
T2541 1495-1496 NN denotes B
T2542 1497-1502 NN denotes cells
T2543 1504-1507 NN denotes BCR
T2544 1508-1511 CC denotes and
T2545 1512-1519 NN denotes phorbol
T2546 1520-1525 NN denotes ester
T2547 1526-1533 NN denotes signals
T2548 1534-1538 VB denotes were
T2549 1539-1543 RB denotes also
T2550 1544-1548 JJ denotes able
T2551 1549-1551 TO denotes to
T2552 1552-1560 VB denotes increase
T2553 1561-1566 NN denotes HSP27
T2554 1567-1582 NN denotes phosphorylation
T2555 1583-1585 IN denotes in
T2556 1586-1590 NN denotes PKD1
T2557 1591-1593 CC denotes or
T2558 1594-1598 NN denotes PKD3
T2559 1599-1605 JJ denotes single
T2560 1606-1614 NN denotes knockout
T2561 1615-1619 NN denotes DT40
T2562 1620-1621 NN denotes B
T2563 1622-1627 NN denotes cells
T2564 1628-1629 -LRB- denotes (
T2565 1629-1633 NN denotes Fig.
T2566 1634-1636 NN denotes 1B
T2567 1636-1637 -RRB- denotes )
T2568 1639-1646 RB denotes However
T2569 1646-1647 -COMMA- denotes ,
T2570 1648-1652 NN denotes BCR-
T2571 1653-1656 CC denotes and
T2572 1657-1664 NN denotes phorbol
T2573 1665-1678 JJ denotes ester-induced
T2574 1679-1694 NN denotes phosphorylation
T2575 1695-1697 IN denotes of
T2576 1698-1703 NN denotes HSP27
T2577 1704-1706 IN denotes on
T2578 1707-1710 NN denotes S82
T2579 1711-1714 VB denotes was
T2580 1715-1724 VB denotes abolished
T2581 1725-1727 IN denotes in
T2582 1728-1729 NN denotes B
T2583 1730-1735 NN denotes cells
T2584 1736-1740 WDT denotes that
T2585 1741-1747 VB denotes lacked
T2586 1748-1752 CC denotes both
T2587 1753-1757 NN denotes PKD1
T2588 1758-1761 CC denotes and
T2589 1762-1766 NN denotes PKD3
T2590 1767-1768 -LRB- denotes (
T2591 1768-1772 NN denotes Fig.
T2592 1773-1775 NN denotes 1C
T2593 1775-1776 -RRB- denotes )
T2594 1778-1791 RB denotes Significantly
T2595 1791-1792 -COMMA- denotes ,
T2596 1793-1812 JJ denotes doxycycline-induced
T2597 1813-1823 NN denotes expression
T2598 1824-1826 IN denotes of
T2599 1827-1830 DT denotes the
T2600 1831-1840 NN denotes Flag-PKD3
T2601 1841-1850 NN denotes transgene
T2602 1851-1853 IN denotes in
T2603 1854-1857 DT denotes the
T2604 1858-1864 JJ denotes double
T2605 1865-1873 NN denotes knockout
T2606 1874-1879 NN denotes cells
T2607 1880-1883 VB denotes was
T2608 1884-1894 JJ denotes sufficient
T2609 1895-1897 TO denotes to
T2610 1898-1905 VB denotes restore
T2611 1906-1912 JJ denotes normal
T2612 1913-1923 NN denotes regulation
T2613 1924-1926 IN denotes of
T2614 1927-1932 NN denotes HSP27
T2615 1933-1948 NN denotes phosphorylation
T2616 1949-1950 -LRB- denotes (
T2617 1950-1954 NN denotes Fig.
T2618 1955-1957 NN denotes 1C
T2619 1957-1958 -RRB- denotes )
T2620 1960-1962 IN denotes In
T2621 1963-1971 NN denotes contrast
T2622 1971-1972 -COMMA- denotes ,
T2623 1973-1983 NN denotes expression
T2624 1984-1986 IN denotes of
T2625 1987-1988 DT denotes a
T2626 1989-2005 JJ denotes kinase-deficient
T2627 2006-2010 NN denotes PKD3
T2628 2011-2017 JJ denotes mutant
T2629 2018-2025 NN denotes protein
T2630 2026-2028 IN denotes in
T2631 2029-2032 DT denotes the
T2632 2033-2039 JJ denotes double
T2633 2040-2048 NN denotes knockout
T2634 2049-2054 NN denotes cells
T2635 2055-2058 VB denotes was
T2636 2059-2062 RB denotes not
T2637 2063-2067 JJ denotes able
T2638 2068-2070 TO denotes to
T2639 2071-2078 VB denotes restore
T2640 2079-2083 NN denotes BCR-
T2641 2084-2086 CC denotes or
T2642 2087-2094 NN denotes phorbol
T2643 2095-2108 JJ denotes ester-induced
T2644 2109-2114 NN denotes HSP27
T2645 2115-2130 NN denotes phosphorylation
T2646 2131-2132 -LRB- denotes (
T2647 2132-2136 NN denotes Fig.
T2648 2137-2139 NN denotes 1D
T2649 2139-2140 -RRB- denotes )
T2650 2142-2147 RB denotes Hence
T2651 2147-2148 -COMMA- denotes ,
T2652 2149-2153 NN denotes PKD3
T2653 2154-2156 RB denotes as
T2654 2157-2161 RB denotes well
T2655 2162-2164 IN denotes as
T2656 2165-2169 NN denotes PKD1
T2657 2170-2173 MD denotes can
T2658 2174-2182 VB denotes regulate
T2659 2183-2188 NN denotes HSP27
T2660 2189-2204 NN denotes phosphorylation
T2661 2205-2208 CC denotes and
T2662 2209-2211 IN denotes in
T2663 2212-2216 NN denotes DT40
T2664 2217-2218 NN denotes B
T2665 2219-2224 NN denotes cells
T2666 2225-2229 PRP denotes they
T2667 2230-2233 VB denotes are
T2668 2234-2246 RB denotes functionally
T2669 2247-2256 JJ denotes redundant
T2670 2257-2259 IN denotes as
T2671 2260-2265 NN denotes HSP27
T2672 2266-2273 NN denotes kinases
R1889 T2291 T2289 arg2Of phosphorylation,of
R1890 T2291 T2290 arg1Of phosphorylation,HSP27
R1891 T2295 T2292 arg2Of cells,in
R1892 T2295 T2293 arg1Of cells,DT40
R1893 T2295 T2294 arg1Of cells,B
R1894 T2295 T2296 arg1Of cells,lacking
R1895 T2297 T2296 arg2Of expression,lacking
R1896 T2297 T2298 arg1Of expression,of
R1897 T2301 T2298 arg2Of kinases,of
R1898 T2301 T2299 arg1Of kinases,PKD
R1899 T2301 T2300 arg1Of kinases,family
R1900 T2304 T2302 arg1Of cells,DT40
R1901 T2304 T2303 arg1Of cells,B
R1902 T2304 T2305 arg1Of cells,express
R1903 T2308 T2305 arg2Of isoforms,express
R1904 T2308 T2306 arg1Of isoforms,two
R1905 T2308 T2307 arg1Of isoforms,PKD
R1906 T2308 T2309 arg1Of isoforms,","
R1907 T2310 T2311 arg1Of PKD1,and
R1908 T2311 T2309 arg2Of and,","
R1909 T2311 T2314 arg1Of and,and
R1910 T2311 T2315 arg1Of and,as
R1911 T2312 T2311 arg2Of PKD3,and
R1912 T2314 T2313 arg1Of and,","
R1913 T2317 T2315 arg2Of described,as
R1914 T2317 T2316 arg1Of described,previously
R1915 T2318 T2319 arg1Of we,have
R1916 T2318 T2321 arg1Of we,generated
R1917 T2321 T2317 arg3Of generated,described
R1918 T2321 T2319 arg2Of generated,have
R1919 T2321 T2320 arg1Of generated,recently
R1920 T2321 T2337 arg1Of generated,[
R1921 T2325 T2321 arg2Of lines,generated
R1922 T2325 T2322 arg1Of lines,DT40
R1923 T2325 T2323 arg1Of lines,B
R1924 T2325 T2324 arg1Of lines,cell
R1925 T2325 T2326 arg1Of lines,that
R1926 T2325 T2327 arg1Of lines,lack
R1927 T2328 T2329 arg1Of expression,of
R1928 T2328 T2334 arg1Of expression,or
R1929 T2331 T2332 arg1Of PKD1,or
R1930 T2332 T2329 arg2Of or,of
R1931 T2332 T2330 arg1Of or,either
R1932 T2333 T2332 arg2Of PKD3,or
R1933 T2334 T2327 arg2Of or,lack
R1934 T2336 T2334 arg2Of enzymes,or
R1935 T2336 T2335 arg1Of enzymes,both
R1936 T2338 T2337 arg2Of 1,[
R1937 T2339 T2337 arg3Of ],[
R1938 T2341 T2340 arg2Of generating,In
R1939 T2346 T2341 arg2Of lines,generating
R1940 T2346 T2342 arg1Of lines,the
R1941 T2346 T2343 arg1Of lines,double
R1942 T2346 T2344 arg1Of lines,knockout
R1943 T2346 T2345 arg1Of lines,cell
R1944 T2347 T2348 arg1Of we,targeted
R1945 T2348 T2340 arg1Of targeted,In
R1946 T2348 T2352 arg1Of targeted,in
R1947 T2351 T2348 arg2Of loci,targeted
R1948 T2351 T2349 arg1Of loci,the
R1949 T2351 T2350 arg1Of loci,PKD1
R1950 T2356 T2352 arg2Of line,in
R1951 T2356 T2353 arg1Of line,a
R1952 T2356 T2354 arg1Of line,PKD3−/−
R1953 T2356 T2355 arg1Of line,cell
R1954 T2356 T2357 arg1Of line,that
R1955 T2356 T2358 arg1Of line,expressed
R1956 T2358 T2362 arg1Of expressed,under
R1957 T2361 T2358 arg2Of transgene,expressed
R1958 T2361 T2359 arg1Of transgene,a
R1959 T2361 T2360 arg1Of transgene,Flag-PKD3
R1960 T2364 T2362 arg2Of control,under
R1961 T2364 T2363 arg1Of control,the
R1962 T2364 T2365 arg1Of control,of
R1963 T2368 T2365 arg2Of promoter,of
R1964 T2368 T2366 arg1Of promoter,a
R1965 T2368 T2367 arg1Of promoter,doxycycline-inducible
R1966 T2373 T2371 arg2Of presence,in
R1967 T2373 T2372 arg1Of presence,the
R1968 T2373 T2374 arg1Of presence,of
R1969 T2375 T2374 arg2Of doxycycline,of
R1970 T2378 T2377 arg1Of expression,Flag-PKD3
R1971 T2378 T2379 arg1Of expression,in
R1972 T2378 T2384 arg1Of expression,is
R1973 T2378 T2385 arg1Of expression,comparable
R1974 T2383 T2379 arg2Of cells,in
R1975 T2383 T2380 arg1Of cells,PKD1/3
R1976 T2383 T2381 arg1Of cells,double
R1977 T2383 T2382 arg1Of cells,knockout
R1978 T2384 T2394 arg1Of is,and
R1979 T2385 T2384 arg2Of comparable,is
R1980 T2385 T2386 arg1Of comparable,to
R1981 T2385 T2390 arg1Of comparable,in
R1982 T2388 T2386 arg2Of PKD3,to
R1983 T2388 T2387 arg1Of PKD3,endogenous
R1984 T2388 T2389 arg1Of PKD3,present
R1985 T2393 T2390 arg2Of cells,in
R1986 T2393 T2391 arg1Of cells,wild-type
R1987 T2393 T2392 arg1Of cells,DT40
R1988 T2394 T2369 arg1Of and,Hence
R1989 T2394 T2370 arg1Of and,","
R1990 T2394 T2371 arg1Of and,in
R1991 T2394 T2376 arg1Of and,","
R1992 T2395 T2396 arg1Of removal,of
R1993 T2395 T2405 arg1Of removal,results
R1994 T2397 T2396 arg2Of doxycycline,of
R1995 T2397 T2398 arg1Of doxycycline,from
R1996 T2397 T2402 arg1Of doxycycline,for
R1997 T2401 T2398 arg2Of media,from
R1998 T2401 T2399 arg1Of media,the
R1999 T2401 T2400 arg1Of media,culture
R2000 T2404 T2402 arg2Of days,for
R2001 T2404 T2403 arg1Of days,5
R2002 T2405 T2394 arg2Of results,and
R2003 T2405 T2406 arg1Of results,in
R2004 T2409 T2408 arg1Of null,completely
R2005 T2411 T2406 arg2Of phenotype,in
R2006 T2411 T2407 arg1Of phenotype,a
R2007 T2411 T2409 arg1Of phenotype,null
R2008 T2411 T2410 arg1Of phenotype,PKD
R2009 T2411 T2412 arg1Of phenotype,(
R2010 T2414 T2412 arg2Of 1A,(
R2011 T2414 T2413 arg1Of 1A,Fig.
R2012 T2415 T2412 arg3Of ),(
R2013 T2418 T2419 arg1Of we,have
R2014 T2418 T2420 arg1Of we,demonstrated
R2015 T2420 T2416 arg1Of demonstrated,Previously
R2016 T2420 T2417 arg1Of demonstrated,","
R2017 T2420 T2419 arg2Of demonstrated,have
R2018 T2422 T2423 arg1Of phosphorylation,and
R2019 T2423 T2426 arg1Of and,of
R2020 T2423 T2437 arg1Of and,is
R2021 T2423 T2438 arg1Of and,defective
R2022 T2423 T2444 arg1Of and,can
R2023 T2423 T2445 arg1Of and,restored
R2024 T2425 T2423 arg2Of exclusion,and
R2025 T2425 T2424 arg1Of exclusion,nuclear
R2026 T2430 T2426 arg2Of deacetylases,of
R2027 T2430 T2427 arg1Of deacetylases,class
R2028 T2430 T2428 arg1Of deacetylases,II
R2029 T2430 T2429 arg1Of deacetylases,histone
R2030 T2430 T2431 arg1Of deacetylases,(
R2031 T2430 T2434 arg1Of deacetylases,during
R2032 T2432 T2431 arg2Of HDACs,(
R2033 T2433 T2431 arg3Of ),(
R2034 T2436 T2434 arg2Of engagement,during
R2035 T2436 T2435 arg1Of engagement,BCR
R2036 T2437 T2443 arg1Of is,and
R2037 T2438 T2437 arg2Of defective,is
R2038 T2438 T2439 arg1Of defective,in
R2039 T2442 T2439 arg2Of cells,in
R2040 T2442 T2440 arg1Of cells,PKD1/3−/−
R2041 T2442 T2441 arg1Of cells,B
R2042 T2443 T2420 arg2Of and,demonstrated
R2043 T2443 T2421 arg1Of and,that
R2044 T2445 T2443 arg2Of restored,and
R2045 T2445 T2444 arg2Of restored,can
R2046 T2445 T2446 arg1Of restored,upon
R2047 T2447 T2446 arg2Of re-expression,upon
R2048 T2447 T2448 arg1Of re-expression,of
R2049 T2452 T2448 arg2Of isoform,of
R2050 T2452 T2449 arg1Of isoform,a
R2051 T2452 T2450 arg1Of isoform,single
R2052 T2452 T2451 arg1Of isoform,PKD
R2053 T2452 T2453 arg1Of isoform,[
R2054 T2454 T2453 arg2Of 1,[
R2055 T2455 T2453 arg3Of ],[
R2056 T2461 T2456 arg1Of HSP27,The
R2057 T2461 T2457 arg1Of HSP27,small
R2058 T2461 T2458 arg1Of HSP27,heat
R2059 T2461 T2459 arg1Of HSP27,shock
R2060 T2461 T2460 arg1Of HSP27,protein
R2061 T2461 T2462 arg1Of HSP27,has
R2062 T2461 T2464 arg1Of HSP27,been
R2063 T2461 T2465 arg2Of HSP27,proposed
R2064 T2465 T2462 arg2Of proposed,has
R2065 T2465 T2463 arg1Of proposed,recently
R2066 T2465 T2464 arg2Of proposed,been
R2067 T2465 T2466 arg1Of proposed,as
R2068 T2465 T2470 arg1Of proposed,[
R2069 T2465 T2473 arg1Of proposed,and
R2070 T2469 T2466 arg2Of substrate,as
R2071 T2469 T2467 arg1Of substrate,a
R2072 T2469 T2468 arg1Of substrate,PKD1
R2073 T2471 T2470 arg2Of 24,[
R2074 T2472 T2470 arg3Of ],[
R2075 T2474 T2476 arg1Of we,assessed
R2076 T2476 T2473 arg2Of assessed,and
R2077 T2476 T2475 arg1Of assessed,accordingly
R2078 T2480 T2478 arg1Of cells,PKD-null
R2079 T2480 T2479 arg1Of cells,DT40
R2080 T2480 T2481 arg1Of cells,have
R2081 T2481 T2476 arg2Of have,assessed
R2082 T2481 T2477 arg1Of have,whether
R2083 T2483 T2481 arg2Of phosphorylation,have
R2084 T2483 T2482 arg1Of phosphorylation,defective
R2085 T2483 T2484 arg1Of phosphorylation,of
R2086 T2485 T2484 arg2Of HSP27,of
R2087 T2485 T2486 arg1Of HSP27,on
R2088 T2485 T2489 arg1Of HSP27,","
R2089 T2487 T2486 arg2Of serine,on
R2090 T2487 T2488 arg1Of serine,82
R2091 T2494 T2489 arg2Of sequence,","
R2092 T2494 T2490 arg1Of sequence,the
R2093 T2494 T2491 arg2Of sequence,proposed
R2094 T2494 T2492 arg1Of sequence,PKD1
R2095 T2494 T2493 arg1Of sequence,substrate
R2096 T2495 T2497 arg1Of We,investigated
R2097 T2497 T2496 arg1Of investigated,initially
R2098 T2499 T2497 arg2Of regulation,investigated
R2099 T2499 T2498 arg1Of regulation,the
R2100 T2499 T2500 arg1Of regulation,of
R2101 T2499 T2503 arg1Of regulation,in
R2102 T2502 T2500 arg2Of phosphorylation,of
R2103 T2502 T2501 arg1Of phosphorylation,HSP27
R2104 T2508 T2503 arg2Of cells,in
R2105 T2508 T2504 arg1Of cells,single
R2106 T2508 T2505 arg1Of cells,knockout
R2107 T2508 T2506 arg1Of cells,DT40
R2108 T2508 T2507 arg1Of cells,B
R2109 T2508 T2509 arg1Of cells,lacking
R2110 T2511 T2512 arg1Of PKD1,or
R2111 T2512 T2509 arg2Of or,lacking
R2112 T2512 T2510 arg1Of or,either
R2113 T2513 T2512 arg2Of PKD3,or
R2114 T2515 T2514 arg2Of shown,As
R2115 T2515 T2516 arg1Of shown,in
R2116 T2518 T2516 arg2Of 1B,in
R2117 T2518 T2517 arg1Of 1B,Fig.
R2118 T2520 T2521 arg1Of activation,of
R2119 T2520 T2524 arg1Of activation,or
R2120 T2523 T2521 arg2Of BCR,of
R2121 T2523 T2522 arg1Of BCR,the
R2122 T2524 T2530 arg1Of or,increased
R2123 T2525 T2524 arg2Of treatment,or
R2124 T2525 T2526 arg1Of treatment,with
R2125 T2529 T2526 arg2Of PdBu,with
R2126 T2529 T2527 arg1Of PdBu,the
R2127 T2529 T2528 arg1Of PdBu,DAG-mimetic
R2128 T2530 T2514 arg1Of increased,As
R2129 T2530 T2519 arg1Of increased,","
R2130 T2532 T2530 arg2Of levels,increased
R2131 T2532 T2531 arg1Of levels,the
R2132 T2532 T2533 arg1Of levels,of
R2133 T2535 T2533 arg2Of phosphorylation,of
R2134 T2535 T2534 arg1Of phosphorylation,HSP27
R2135 T2535 T2536 arg1Of phosphorylation,at
R2136 T2537 T2536 arg2Of S82,at
R2137 T2537 T2538 arg1Of S82,in
R2138 T2542 T2538 arg2Of cells,in
R2139 T2542 T2539 arg1Of cells,wild-type
R2140 T2542 T2540 arg1Of cells,DT40
R2141 T2542 T2541 arg1Of cells,B
R2142 T2543 T2544 arg1Of BCR,and
R2143 T2545 T2544 arg2Of phorbol,and
R2144 T2547 T2543 arg1Of signals,BCR
R2145 T2547 T2545 arg1Of signals,phorbol
R2146 T2547 T2546 arg1Of signals,ester
R2147 T2547 T2548 arg1Of signals,were
R2148 T2547 T2550 arg1Of signals,able
R2149 T2547 T2552 arg1Of signals,increase
R2150 T2548 T2549 arg1Of were,also
R2151 T2550 T2548 arg2Of able,were
R2152 T2552 T2550 arg2Of increase,able
R2153 T2552 T2551 arg1Of increase,to
R2154 T2554 T2552 arg2Of phosphorylation,increase
R2155 T2554 T2553 arg1Of phosphorylation,HSP27
R2156 T2554 T2555 arg1Of phosphorylation,in
R2157 T2556 T2557 arg1Of PKD1,or
R2158 T2558 T2557 arg2Of PKD3,or
R2159 T2563 T2555 arg2Of cells,in
R2160 T2563 T2556 arg1Of cells,PKD1
R2161 T2563 T2558 arg1Of cells,PKD3
R2162 T2563 T2559 arg1Of cells,single
R2163 T2563 T2560 arg1Of cells,knockout
R2164 T2563 T2561 arg1Of cells,DT40
R2165 T2563 T2562 arg1Of cells,B
R2166 T2563 T2564 arg1Of cells,(
R2167 T2566 T2564 arg2Of 1B,(
R2168 T2566 T2565 arg1Of 1B,Fig.
R2169 T2567 T2564 arg3Of ),(
R2170 T2570 T2571 arg1Of BCR-,and
R2171 T2571 T2577 arg1Of and,on
R2172 T2571 T2579 arg1Of and,was
R2173 T2571 T2580 arg2Of and,abolished
R2174 T2573 T2572 arg1Of ester-induced,phorbol
R2175 T2574 T2571 arg2Of phosphorylation,and
R2176 T2574 T2573 arg1Of phosphorylation,ester-induced
R2177 T2574 T2575 arg1Of phosphorylation,of
R2178 T2576 T2575 arg2Of HSP27,of
R2179 T2578 T2577 arg2Of S82,on
R2180 T2580 T2568 arg1Of abolished,However
R2181 T2580 T2569 arg1Of abolished,","
R2182 T2580 T2579 arg2Of abolished,was
R2183 T2580 T2581 arg1Of abolished,in
R2184 T2583 T2581 arg2Of cells,in
R2185 T2583 T2582 arg1Of cells,B
R2186 T2583 T2584 arg1Of cells,that
R2187 T2583 T2585 arg1Of cells,lacked
R2188 T2587 T2588 arg1Of PKD1,and
R2189 T2588 T2585 arg2Of and,lacked
R2190 T2588 T2586 arg1Of and,both
R2191 T2588 T2590 arg1Of and,(
R2192 T2589 T2588 arg2Of PKD3,and
R2193 T2592 T2590 arg2Of 1C,(
R2194 T2592 T2591 arg1Of 1C,Fig.
R2195 T2593 T2590 arg3Of ),(
R2196 T2597 T2596 arg1Of expression,doxycycline-induced
R2197 T2597 T2598 arg1Of expression,of
R2198 T2597 T2602 arg1Of expression,in
R2199 T2597 T2607 arg1Of expression,was
R2200 T2597 T2608 arg1Of expression,sufficient
R2201 T2601 T2598 arg2Of transgene,of
R2202 T2601 T2599 arg1Of transgene,the
R2203 T2601 T2600 arg1Of transgene,Flag-PKD3
R2204 T2606 T2602 arg2Of cells,in
R2205 T2606 T2603 arg1Of cells,the
R2206 T2606 T2604 arg1Of cells,double
R2207 T2606 T2605 arg1Of cells,knockout
R2208 T2607 T2594 arg1Of was,Significantly
R2209 T2607 T2595 arg1Of was,","
R2210 T2607 T2609 modOf was,to
R2211 T2608 T2607 arg2Of sufficient,was
R2212 T2610 T2609 arg1Of restore,to
R2213 T2612 T2610 arg2Of regulation,restore
R2214 T2612 T2611 arg1Of regulation,normal
R2215 T2612 T2613 arg1Of regulation,of
R2216 T2615 T2613 arg2Of phosphorylation,of
R2217 T2615 T2614 arg1Of phosphorylation,HSP27
R2218 T2615 T2616 arg1Of phosphorylation,(
R2219 T2618 T2616 arg2Of 1C,(
R2220 T2618 T2617 arg1Of 1C,Fig.
R2221 T2619 T2616 arg3Of ),(
R2222 T2621 T2620 arg2Of contrast,In
R2223 T2623 T2624 arg1Of expression,of
R2224 T2623 T2630 arg1Of expression,in
R2225 T2623 T2635 arg1Of expression,was
R2226 T2623 T2637 arg1Of expression,able
R2227 T2623 T2639 arg1Of expression,restore
R2228 T2629 T2624 arg2Of protein,of
R2229 T2629 T2625 arg1Of protein,a
R2230 T2629 T2626 arg1Of protein,kinase-deficient
R2231 T2629 T2627 arg1Of protein,PKD3
R2232 T2629 T2628 arg1Of protein,mutant
R2233 T2634 T2630 arg2Of cells,in
R2234 T2634 T2631 arg1Of cells,the
R2235 T2634 T2632 arg1Of cells,double
R2236 T2634 T2633 arg1Of cells,knockout
R2237 T2635 T2620 arg1Of was,In
R2238 T2635 T2622 arg1Of was,","
R2239 T2635 T2636 arg1Of was,not
R2240 T2637 T2635 arg2Of able,was
R2241 T2639 T2637 arg2Of restore,able
R2242 T2639 T2638 arg1Of restore,to
R2243 T2640 T2641 arg1Of BCR-,or
R2244 T2641 T2639 arg2Of or,restore
R2245 T2645 T2641 arg2Of phosphorylation,or
R2246 T2645 T2642 arg1Of phosphorylation,phorbol
R2247 T2645 T2643 arg1Of phosphorylation,ester-induced
R2248 T2645 T2644 arg1Of phosphorylation,HSP27
R2249 T2645 T2646 arg1Of phosphorylation,(
R2250 T2648 T2646 arg2Of 1D,(
R2251 T2648 T2647 arg1Of 1D,Fig.
R2252 T2649 T2646 arg3Of ),(
R2253 T2652 T2655 arg1Of PKD3,as
R2254 T2655 T2653 arg1Of as,as
R2255 T2655 T2654 arg1Of as,well
R2256 T2655 T2657 arg1Of as,can
R2257 T2655 T2658 arg1Of as,regulate
R2258 T2656 T2655 arg2Of PKD1,as
R2259 T2658 T2657 arg2Of regulate,can
R2260 T2658 T2661 arg1Of regulate,and
R2261 T2660 T2658 arg2Of phosphorylation,regulate
R2262 T2660 T2659 arg1Of phosphorylation,HSP27
R2263 T2661 T2650 arg1Of and,Hence
R2264 T2661 T2651 arg1Of and,","
R2265 T2665 T2662 arg2Of cells,in
R2266 T2665 T2663 arg1Of cells,DT40
R2267 T2665 T2664 arg1Of cells,B
R2268 T2666 T2667 arg1Of they,are
R2269 T2666 T2669 arg2Of they,redundant
R2270 T2669 T2661 arg2Of redundant,and
R2271 T2669 T2662 arg1Of redundant,in
R2272 T2669 T2667 arg2Of redundant,are
R2273 T2669 T2668 arg1Of redundant,functionally
R2274 T2669 T2670 arg1Of redundant,as
R2275 T2672 T2670 arg2Of kinases,as
R2276 T2672 T2671 arg1Of kinases,HSP27