PMC:1310901 / 21663-28193 JSON TXT 20 Projects

Annnotations TAB TSV DIC JSON TextAE

Id	Subject	Object	Predicate	Lexical cue
T11346	11-15	JJ	denotes	Many
T11347	16-23	JJ	denotes	genetic
T11348	24-31	NN	denotes	lesions
T11349	32-35	VB	denotes	are
T11350	36-41	VB	denotes	known
T11351	42-44	TO	denotes	to
T11352	45-54	VB	denotes	influence
T11353	55-59	NN	denotes	gene
T11354	60-70	NN	denotes	expression
T11355	71-73	IN	denotes	of
T11356	74-79	NN	denotes	tumor
T11357	80-90	NN	denotes	suppressor
T11358	91-96	NN	denotes	genes
T11359	98-105	IN	denotes	Whereas
T11360	106-115	NN	denotes	mutations
T11361	116-119	CC	denotes	and
T11362	120-129	NN	denotes	deletions
T11363	130-132	CC	denotes	or
T11364	133-143	NN	denotes	insertions
T11365	144-148	VB	denotes	have
T11366	149-158	JJ	denotes	permanent
T11367	159-166	NN	denotes	effects
T11368	166-167	-COMMA-	denotes	,
T11369	168-178	JJ	denotes	reversible
T11370	179-189	NN	denotes	mechanisms
T11371	190-193	VB	denotes	are
T11372	194-198	NN	denotes	gene
T11373	199-210	NN	denotes	methylation
T11374	210-211	-COMMA-	denotes	,
T11375	212-214	CC	denotes	or
T11376	215-225	NN	denotes	expression
T11377	226-229	CC	denotes	and
T11378	230-240	NN	denotes	activation
T11379	241-243	IN	denotes	of
T11380	244-257	NN	denotes	transcription
T11381	258-265	NN	denotes	factors
T11382	265-266	-COMMA-	denotes	,
T11383	267-279	RB	denotes	respectively
T11384	281-283	PRP	denotes	We
T11385	284-291	VB	denotes	studied
T11386	292-293	DT	denotes	a
T11387	294-302	JJ	denotes	putative
T11388	303-308	NN	denotes	cause
T11389	309-312	IN	denotes	for
T11390	313-319	JJ	denotes	absent
T11391	320-325	NN	denotes	IRF-4
T11392	326-336	NN	denotes	expression
T11393	337-339	IN	denotes	in
T11394	340-348	NN	denotes	leukemia
T11395	349-354	NN	denotes	cells
T11396	355-358	CC	denotes	and
T11397	359-364	RB	denotes	first
T11398	365-372	VB	denotes	focused
T11399	373-375	IN	denotes	on
T11400	376-383	JJ	denotes	genetic
T11401	384-395	NN	denotes	aberrations
T11402	396-398	IN	denotes	of
T11403	399-402	DT	denotes	the
T11404	403-411	NN	denotes	promoter
T11405	413-415	PRP	denotes	We
T11406	416-424	VB	denotes	observed
T11407	425-427	DT	denotes	no
T11408	428-435	JJ	denotes	genetic
T11409	436-447	NN	denotes	alterations
T11410	448-450	IN	denotes	in
T11411	451-454	DT	denotes	the
T11412	455-460	NN	denotes	IRF-4
T11413	461-469	NN	denotes	promoter
T11414	469-470	-COMMA-	denotes	,
T11415	471-476	WDT	denotes	which
T11416	477-480	MD	denotes	can
T11417	481-488	VB	denotes	account
T11418	489-492	IN	denotes	for
T11419	493-496	DT	denotes	the
T11420	497-501	NN	denotes	lack
T11421	502-504	IN	denotes	of
T11422	505-510	NN	denotes	IRF-4
T11423	511-521	NN	denotes	expression
T11424	521-522	-COLON-	denotes	:
T11425	523-526	DT	denotes	The
T11426	527-535	VB	denotes	detected
T11427	536-540	NN	denotes	base
T11428	541-545	NN	denotes	pair
T11429	546-553	NN	denotes	changes
T11430	554-556	IN	denotes	at
T11431	557-565	NN	denotes	position
T11432	566-571	NN	denotes	−1081
T11433	572-573	-LRB-	denotes	(
T11434	573-576	NN	denotes	T→C
T11435	577-589	NN	denotes	substitution
T11436	589-590	-RRB-	denotes	)
T11437	590-591	-COMMA-	denotes	,
T11438	592-594	IN	denotes	at
T11439	595-603	NN	denotes	position
T11440	604-609	CD	denotes	−1068
T11441	610-611	-LRB-	denotes	(
T11442	611-614	NN	denotes	A→C
T11443	615-627	NN	denotes	substitution
T11444	627-628	-RRB-	denotes	)
T11445	629-632	CC	denotes	and
T11446	633-635	IN	denotes	at
T11447	636-644	NN	denotes	position
T11448	645-649	CD	denotes	−116
T11449	650-651	-LRB-	denotes	(
T11450	651-654	NN	denotes	A→C
T11451	655-667	NN	denotes	substitution
T11452	667-668	-RRB-	denotes	)
T11453	669-672	VB	denotes	are
T11454	673-681	JJ	denotes	unlikely
T11455	682-693	JJ	denotes	responsible
T11456	694-697	IN	denotes	for
T11457	698-704	JJ	denotes	absent
T11458	705-721	NN	denotes	IRF-4-expression
T11459	722-727	IN	denotes	since
T11460	728-731	DT	denotes	the
T11461	732-737	JJ	denotes	first
T11462	738-741	CD	denotes	two
T11463	742-751	NN	denotes	mutations
T11464	752-756	VB	denotes	were
T11465	757-762	VB	denotes	found
T11466	763-767	CC	denotes	both
T11467	768-770	IN	denotes	in
T11468	771-785	JJ	denotes	IRF-4-positive
T11469	786-789	CC	denotes	and
T11470	790-799	JJ	denotes	-negative
T11471	800-805	NN	denotes	cells
T11472	806-813	IN	denotes	whereas
T11473	814-817	DT	denotes	the
T11474	818-824	JJ	denotes	latter
T11475	825-831	NN	denotes	change
T11476	832-835	VB	denotes	was
T11477	836-839	RB	denotes	not
T11478	840-848	VB	denotes	detected
T11479	849-861	RB	denotes	consistently
T11480	862-864	IN	denotes	in
T11481	865-868	DT	denotes	all
T11482	869-883	JJ	denotes	IRF-4-negative
T11483	884-886	CC	denotes	or
T11484	887-896	JJ	denotes	-positive
T11485	897-902	NN	denotes	cells
T11486	903-906	CC	denotes	and
T11487	907-910	MD	denotes	may
T11488	911-915	RB	denotes	thus
T11489	916-918	VB	denotes	be
T11490	919-920	DT	denotes	a
T11491	921-933	NN	denotes	polymorphism
T11492	935-938	DT	denotes	All
T11493	939-944	CD	denotes	three
T11494	945-958	NN	denotes	substitutions
T11495	959-962	VB	denotes	did
T11496	963-966	RB	denotes	not
T11497	967-973	VB	denotes	change
T11498	974-977	DT	denotes	any
T11499	978-983	JJ	denotes	known
T11500	984-992	JJ	denotes	putative
T11501	993-1006	NN	denotes	transcription
T11502	1007-1013	NN	denotes	factor
T11503	1014-1021	NN	denotes	binding
T11504	1022-1027	NN	denotes	sites
T11505	1028-1029	-LRB-	denotes	(
T11506	1029-1034	CD	denotes	30,31
T11507	1034-1035	-RRB-	denotes	)
T11508	1036-1039	CC	denotes	and
T11509	1040-1044	RB	denotes	also
T11510	1045-1047	VB	denotes	do
T11511	1048-1051	RB	denotes	not
T11512	1052-1058	VB	denotes	affect
T11513	1059-1062	DT	denotes	any
T11514	1063-1074	NN	denotes	restriction
T11515	1075-1080	NN	denotes	sites
T11516	1081-1083	CC	denotes	or
T11517	1084-1090	NN	denotes	primer
T11518	1091-1098	NN	denotes	binding
T11519	1099-1104	NN	denotes	sites
T11520	1105-1107	IN	denotes	of
T11521	1108-1111	DT	denotes	the
T11522	1112-1116	VB	denotes	used
T11523	1117-1123	NN	denotes	assays
T11524	1125-1132	RB	denotes	However
T11525	1132-1133	-COMMA-	denotes	,
T11526	1134-1143	JJ	denotes	permanent
T11527	1144-1151	JJ	denotes	genetic
T11528	1152-1162	NN	denotes	variations
T11529	1163-1165	IN	denotes	in
T11530	1166-1169	DT	denotes	the
T11531	1170-1175	NN	denotes	IRF-4
T11532	1176-1182	NN	denotes	coding
T11533	1183-1191	NN	denotes	sequence
T11534	1191-1192	-COMMA-	denotes	,
T11535	1193-1197	JJ	denotes	such
T11536	1198-1200	IN	denotes	as
T11537	1201-1210	NN	denotes	deletions
T11538	1211-1213	CC	denotes	or
T11539	1214-1223	NN	denotes	mutations
T11540	1224-1233	VB	denotes	resulting
T11541	1234-1236	IN	denotes	in
T11542	1237-1248	NN	denotes	stop-codons
T11543	1249-1253	VB	denotes	have
T11544	1254-1257	RB	denotes	not
T11545	1258-1262	VB	denotes	been
T11546	1263-1271	VB	denotes	excluded
T11547	1272-1274	IN	denotes	by
T11548	1275-1283	NN	denotes	sequence
T11549	1284-1292	NN	denotes	analysis
T11550	1294-1299	IN	denotes	Since
T11551	1300-1305	NN	denotes	IRF-4
T11552	1306-1316	NN	denotes	expression
T11553	1317-1319	IN	denotes	in
T11554	1320-1324	NN	denotes	cell
T11555	1325-1330	NN	denotes	lines
T11556	1331-1334	CC	denotes	and
T11557	1335-1338	NN	denotes	CML
T11558	1339-1342	MD	denotes	can
T11559	1343-1345	VB	denotes	be
T11560	1346-1353	VB	denotes	induced
T11561	1354-1356	IN	denotes	by
T11562	1357-1370	NN	denotes	demethylation
T11563	1371-1374	CC	denotes	and
T11564	1375-1385	JJ	denotes	successful
T11565	1386-1391	NN	denotes	IFN-α
T11566	1392-1399	NN	denotes	therapy
T11567	1400-1401	-LRB-	denotes	(
T11568	1401-1402	CD	denotes	3
T11569	1402-1403	-RRB-	denotes	)
T11570	1403-1404	-COMMA-	denotes	,
T11571	1405-1417	RB	denotes	respectively
T11572	1417-1418	-COMMA-	denotes	,
T11573	1419-1422	DT	denotes	the
T11574	1423-1432	NN	denotes	existence
T11575	1433-1435	IN	denotes	of
T11576	1436-1440	JJ	denotes	such
T11577	1441-1448	JJ	denotes	genetic
T11578	1449-1460	NN	denotes	aberrations
T11579	1461-1466	VB	denotes	seems
T11580	1467-1475	JJ	denotes	unlikely
T11581	1477-1479	PRP	denotes	We
T11582	1480-1484	RB	denotes	then
T11583	1485-1497	VB	denotes	investigated
T11584	1498-1505	IN	denotes	whether
T11585	1506-1509	DT	denotes	the
T11586	1510-1520	RB	denotes	previously
T11587	1521-1530	VB	denotes	described
T11588	1531-1546	NN	denotes	down-regulation
T11589	1547-1549	IN	denotes	of
T11590	1550-1555	NN	denotes	IRF-4
T11591	1556-1566	NN	denotes	expression
T11592	1567-1569	IN	denotes	in
T11593	1570-1575	JJ	denotes	human
T11594	1576-1583	JJ	denotes	myeloid
T11595	1584-1593	NN	denotes	leukemias
T11596	1594-1597	VB	denotes	was
T11597	1598-1601	JJ	denotes	due
T11598	1602-1604	TO	denotes	to
T11599	1605-1606	DT	denotes	a
T11600	1607-1619	JJ	denotes	differential
T11601	1620-1636	NN	denotes	hypermethylation
T11602	1637-1639	IN	denotes	of
T11603	1640-1643	DT	denotes	the
T11604	1644-1652	NN	denotes	promoter
T11605	1652-1653	-COMMA-	denotes	,
T11606	1654-1659	IN	denotes	since
T11607	1660-1663	DT	denotes	the
T11608	1664-1673	VB	denotes	presented
T11609	1674-1687	NN	denotes	re-expression
T11610	1688-1691	IN	denotes	due
T11611	1692-1694	TO	denotes	to
T11612	1695-1710	NN	denotes	AzadC-treatment
T11613	1711-1716	MD	denotes	might
T11614	1717-1721	RB	denotes	also
T11615	1722-1724	VB	denotes	be
T11616	1725-1726	DT	denotes	a
T11617	1727-1733	NN	denotes	result
T11618	1734-1736	IN	denotes	of
T11619	1737-1747	NN	denotes	activation
T11620	1748-1750	IN	denotes	of
T11621	1751-1759	JJ	denotes	positive
T11622	1760-1775	JJ	denotes	transcriptional
T11623	1776-1786	NN	denotes	regulators
T11624	1787-1789	IN	denotes	of
T11625	1790-1795	NN	denotes	IRF-4
T11626	1797-1808	NN	denotes	Methylation
T11627	1809-1811	IN	denotes	of
T11628	1812-1815	NN	denotes	CpG
T11629	1816-1821	NN	denotes	sites
T11630	1822-1824	VB	denotes	is
T11631	1825-1826	DT	denotes	a
T11632	1827-1833	JJ	denotes	common
T11633	1834-1843	NN	denotes	mechanism
T11634	1844-1846	IN	denotes	of
T11635	1847-1856	NN	denotes	silencing
T11636	1857-1862	NN	denotes	genes
T11637	1863-1865	IN	denotes	in
T11638	1866-1874	NN	denotes	leukemia
T11639	1875-1878	CC	denotes	and
T11640	1879-1882	VB	denotes	has
T11641	1883-1887	RB	denotes	also
T11642	1888-1892	VB	denotes	been
T11643	1893-1898	VB	denotes	shown
T11644	1899-1902	IN	denotes	for
T11645	1903-1910	DT	denotes	another
T11646	1911-1914	NN	denotes	IRF
T11647	1914-1915	-COMMA-	denotes	,
T11648	1916-1921	NN	denotes	IRF-7
T11649	1922-1923	-LRB-	denotes	(
T11650	1923-1925	CD	denotes	35
T11651	1925-1926	-RRB-	denotes	)
T11652	1927-1930	CC	denotes	and
T11653	1931-1934	IN	denotes	for
T11654	1935-1939	NN	denotes	PU.1
T11655	1940-1941	-LRB-	denotes	(
T11656	1941-1943	CD	denotes	36
T11657	1943-1944	-RRB-	denotes	)
T11658	1944-1945	-COMMA-	denotes	,
T11659	1946-1948	DT	denotes	an
T11660	1949-1960	VB	denotes	interacting
T11661	1961-1968	NN	denotes	partner
T11662	1969-1971	IN	denotes	of
T11663	1972-1977	NN	denotes	IRF-4
T11664	1979-1981	TO	denotes	To
T11665	1982-1991	VB	denotes	elucidate
T11666	1992-1995	DT	denotes	the
T11667	1996-2005	NN	denotes	relevance
T11668	2006-2008	IN	denotes	of
T11669	2009-2013	DT	denotes	this
T11670	2014-2023	NN	denotes	mechanism
T11671	2024-2027	IN	denotes	for
T11672	2028-2031	DT	denotes	the
T11673	2032-2042	NN	denotes	regulation
T11674	2043-2045	IN	denotes	of
T11675	2046-2051	NN	denotes	IRF-4
T11676	2052-2062	NN	denotes	expression
T11677	2062-2063	-COMMA-	denotes	,
T11678	2064-2071	JJ	denotes	various
T11679	2072-2080	JJ	denotes	leukemic
T11680	2081-2086	NN	denotes	cells
T11681	2087-2091	VB	denotes	were
T11682	2092-2099	VB	denotes	treated
T11683	2100-2104	IN	denotes	with
T11684	2105-2118	VB	denotes	demethylating
T11685	2119-2125	NN	denotes	agents
T11686	2126-2129	CC	denotes	and
T11687	2130-2139	NN	denotes	promoters
T11688	2140-2144	VB	denotes	were
T11689	2145-2154	VB	denotes	sequenced
T11690	2155-2160	IN	denotes	after
T11691	2161-2170	NN	denotes	bisulfite
T11692	2171-2180	NN	denotes	treatment
T11693	2182-2184	PRP	denotes	We
T11694	2185-2190	VB	denotes	found
T11695	2191-2195	IN	denotes	that
T11696	2196-2201	NN	denotes	IRF-4
T11697	2202-2212	NN	denotes	expression
T11698	2213-2218	MD	denotes	could
T11699	2219-2225	RB	denotes	indeed
T11700	2226-2228	VB	denotes	be
T11701	2229-2238	VB	denotes	connected
T11702	2239-2241	TO	denotes	to
T11703	2242-2245	DT	denotes	the
T11704	2246-2257	NN	denotes	methylation
T11705	2258-2264	NN	denotes	status
T11706	2265-2267	IN	denotes	of
T11707	2268-2276	JJ	denotes	distinct
T11708	2277-2280	NN	denotes	CpG
T11709	2281-2287	NN	denotes	motifs
T11710	2288-2290	IN	denotes	in
T11711	2291-2294	DT	denotes	the
T11712	2295-2300	NN	denotes	IRF-4
T11713	2301-2309	NN	denotes	promoter
T11714	2311-2313	IN	denotes	In
T11715	2314-2320	NN	denotes	Figure
T11716	2321-2323	NN	denotes	4A
T11717	2323-2324	-COMMA-	denotes	,
T11718	2325-2330	DT	denotes	those
T11719	2331-2334	NN	denotes	CpG
T11720	2335-2340	NN	denotes	sites
T11721	2341-2344	VB	denotes	are
T11722	2345-2350	VB	denotes	shown
T11723	2351-2352	-LRB-	denotes	(
T11724	2352-2358	JJ	denotes	bottom
T11725	2359-2363	NN	denotes	line
T11726	2363-2364	-RRB-	denotes	)
T11727	2364-2365	-COMMA-	denotes	,
T11728	2366-2371	WP-DOLLAR-	denotes	whose
T11729	2372-2388	NN	denotes	hypermethylation
T11730	2389-2392	MD	denotes	may
T11731	2393-2400	VB	denotes	account
T11732	2401-2404	IN	denotes	for
T11733	2405-2408	DT	denotes	the
T11734	2409-2416	NN	denotes	absence
T11735	2417-2419	IN	denotes	of
T11736	2420-2425	NN	denotes	IRF-4
T11737	2426-2436	NN	denotes	expression
T11738	2437-2439	IN	denotes	in
T11739	2440-2443	DT	denotes	the
T11740	2444-2454	JJ	denotes	respective
T11741	2455-2460	NN	denotes	cells
T11742	2462-2465	CD	denotes	One
T11743	2466-2468	IN	denotes	of
T11744	2469-2473	PRP	denotes	them
T11745	2474-2475	-LRB-	denotes	(
T11746	2475-2476	-SHARP-	denotes	#
T11747	2476-2478	CD	denotes	54
T11748	2478-2479	-RRB-	denotes	)
T11749	2480-2482	VB	denotes	is
T11750	2483-2491	JJ	denotes	adjacent
T11751	2492-2494	TO	denotes	to
T11752	2495-2497	DT	denotes	an
T11753	2498-2508	VB	denotes	identified
T11754	2509-2519	JJ	denotes	regulatory
T11755	2520-2527	NN	denotes	element
T11756	2528-2529	-LRB-	denotes	(
T11757	2529-2538	NN	denotes	NFκB-site
T11758	2538-2539	-RRB-	denotes	)
T11759	2539-2540	-COMMA-	denotes	,
T11760	2541-2551	VB	denotes	indicating
T11761	2552-2553	DT	denotes	a
T11762	2554-2562	JJ	denotes	possible
T11763	2563-2574	NN	denotes	involvement
T11764	2575-2577	IN	denotes	of
T11765	2578-2582	DT	denotes	this
T11766	2583-2587	NN	denotes	site
T11767	2589-2591	IN	denotes	At
T11768	2592-2595	CD	denotes	two
T11769	2596-2603	JJ	denotes	further
T11770	2604-2607	NN	denotes	CpG
T11771	2608-2613	NN	denotes	sites
T11772	2614-2615	-LRB-	denotes	(
T11773	2615-2616	-SHARP-	denotes	#
T11774	2616-2618	CD	denotes	48
T11775	2618-2619	-COMMA-	denotes	,
T11776	2620-2622	CD	denotes	45
T11777	2622-2623	-RRB-	denotes	)
T11778	2624-2627	DT	denotes	the
T11779	2628-2639	NN	denotes	methylation
T11780	2640-2646	NN	denotes	status
T11781	2647-2649	IN	denotes	in
T11782	2650-2664	JJ	denotes	IRF-4-positive
T11783	2665-2668	VB	denotes	was
T11784	2669-2674	JJ	denotes	lower
T11785	2675-2679	IN	denotes	than
T11786	2680-2684	DT	denotes	that
T11787	2685-2687	IN	denotes	of
T11788	2688-2702	JJ	denotes	IRF-4-negative
T11789	2703-2708	NN	denotes	cells
T11790	2710-2715	DT	denotes	These
T11791	2716-2719	NN	denotes	CpG
T11792	2720-2725	NN	denotes	sites
T11793	2726-2729	VB	denotes	are
T11794	2730-2737	JJ	denotes	located
T11795	2738-2740	IN	denotes	in
T11796	2741-2743	DT	denotes	an
T11797	2744-2748	NN	denotes	NFκB
T11798	2749-2752	CC	denotes	and
T11799	2753-2755	DT	denotes	an
T11800	2756-2759	NN	denotes	SP1
T11801	2760-2767	NN	denotes	element
T11802	2768-2769	-LRB-	denotes	(
T11803	2769-2771	CD	denotes	31
T11804	2771-2772	-RRB-	denotes	)
T11805	2773-2776	CC	denotes	and
T11806	2777-2781	RB	denotes	thus
T11807	2782-2785	MD	denotes	may
T11808	2786-2790	RB	denotes	also
T11809	2791-2795	VB	denotes	play
T11810	2796-2797	DT	denotes	a
T11811	2798-2802	NN	denotes	role
T11812	2803-2805	IN	denotes	in
T11813	2806-2816	NN	denotes	regulation
T11814	2817-2819	IN	denotes	of
T11815	2820-2825	NN	denotes	IRF-4
T11816	2826-2836	NN	denotes	expression
T11817	2838-2840	PRP	denotes	It
T11818	2841-2844	VB	denotes	has
T11819	2845-2849	VB	denotes	been
T11820	2850-2855	VB	denotes	shown
T11821	2856-2860	IN	denotes	that
T11822	2861-2865	NN	denotes	NFκB
T11823	2866-2874	NN	denotes	elements
T11824	2875-2879	VB	denotes	play
T11825	2880-2882	DT	denotes	an
T11826	2883-2892	JJ	denotes	important
T11827	2893-2897	NN	denotes	role
T11828	2898-2900	IN	denotes	in
T11829	2901-2906	NN	denotes	IRF-4
T11830	2907-2916	NN	denotes	induction
T11831	2917-2919	IN	denotes	as
T11832	2920-2925	NN	denotes	IRF-4
T11833	2926-2936	NN	denotes	expression
T11834	2937-2944	VB	denotes	depends
T11835	2945-2947	IN	denotes	on
T11836	2948-2955	NN	denotes	binding
T11837	2956-2958	IN	denotes	of
T11838	2959-2962	DT	denotes	the
T11839	2963-2977	NN	denotes	transactivator
T11840	2978-2983	NN	denotes	c-Rel
T11841	2984-2986	TO	denotes	to
T11842	2987-2992	DT	denotes	these
T11843	2993-3001	NN	denotes	elements
T11844	3002-3004	IN	denotes	in
T11845	3005-3008	DT	denotes	the
T11846	3009-3014	NN	denotes	IRF-4
T11847	3015-3023	NN	denotes	promoter
T11848	3024-3025	-LRB-	denotes	(
T11849	3025-3030	CD	denotes	31,37
T11850	3030-3031	-RRB-	denotes	)
T11851	3033-3044	RB	denotes	Furthermore
T11852	3044-3045	-COMMA-	denotes	,
T11853	3046-3057	NN	denotes	methylation
T11854	3058-3060	IN	denotes	of
T11855	3061-3064	DT	denotes	the
T11856	3065-3072	JJ	denotes	central
T11857	3073-3076	NN	denotes	CpG
T11858	3077-3079	IN	denotes	in
T11859	3080-3083	DT	denotes	the
T11860	3084-3088	NN	denotes	NFκB
T11861	3089-3096	NN	denotes	element
T11862	3097-3105	VB	denotes	inhibits
T11863	3106-3113	NN	denotes	binding
T11864	3114-3116	IN	denotes	of
T11865	3117-3120	DT	denotes	the
T11866	3121-3125	NN	denotes	NFκB
T11867	3126-3133	NN	denotes	protein
T11868	3134-3143	NN	denotes	complexes
T11869	3144-3145	-LRB-	denotes	(
T11870	3145-3147	CD	denotes	38
T11871	3147-3148	-RRB-	denotes	)
T11872	3148-3149	-COMMA-	denotes	,
T11873	3150-3159	VB	denotes	promoting
T11874	3160-3163	DT	denotes	the
T11875	3164-3176	NN	denotes	significance
T11876	3177-3179	IN	denotes	of
T11877	3180-3183	DT	denotes	the
T11878	3184-3192	VB	denotes	observed
T11879	3193-3204	NN	denotes	methylation
T11880	3205-3216	NN	denotes	differences
T11881	3217-3219	IN	denotes	in
T11882	3220-3234	JJ	denotes	IRF-4-positive
T11883	3235-3238	CC	denotes	and
T11884	3239-3248	JJ	denotes	-negative
T11885	3249-3254	NN	denotes	cells
T11886	3256-3259	NNP	denotes	Via
T11887	3260-3262	FW	denotes	in
T11888	3263-3268	FW	denotes	vitro
T11889	3269-3280	NN	denotes	methylation
T11890	3281-3284	CC	denotes	and
T11891	3285-3293	NN	denotes	reporter
T11892	3294-3298	NN	denotes	gene
T11893	3299-3305	NN	denotes	assays
T11894	3306-3308	PRP	denotes	we
T11895	3309-3314	MD	denotes	could
T11896	3315-3322	RB	denotes	clearly
T11897	3323-3330	VB	denotes	appoint
T11898	3331-3334	DT	denotes	the
T11899	3335-3344	NN	denotes	silencing
T11900	3345-3347	IN	denotes	of
T11901	3348-3351	DT	denotes	the
T11902	3352-3357	NN	denotes	IRF-4
T11903	3358-3366	NN	denotes	promoter
T11904	3367-3369	TO	denotes	to
T11905	3370-3371	DT	denotes	a
T11906	3372-3383	NN	denotes	methylation
T11907	3384-3390	NN	denotes	effect
T11908	3390-3391	-COMMA-	denotes	,
T11909	3392-3397	WDT	denotes	which
T11910	3398-3401	MD	denotes	may
T11911	3402-3406	RB	denotes	thus
T11912	3407-3409	VB	denotes	be
T11913	3410-3413	DT	denotes	the
T11914	3414-3423	NN	denotes	mechanism
T11915	3424-3426	IN	denotes	of
T11916	3427-3432	NN	denotes	IRF-4
T11917	3433-3445	NN	denotes	deregulation
T11918	3446-3448	FW	denotes	in
T11919	3449-3453	FW	denotes	vivo
T11920	3455-3458	CD	denotes	One
T11921	3459-3467	JJ	denotes	possible
T11922	3468-3473	NN	denotes	cause
T11923	3474-3477	IN	denotes	for
T11924	3478-3481	DT	denotes	the
T11925	3482-3490	JJ	denotes	aberrant
T11926	3491-3502	NN	denotes	methylation
T11927	3503-3505	IN	denotes	in
T11928	3506-3519	NN	denotes	tumorigenesis
T11929	3520-3522	VB	denotes	is
T11930	3523-3525	DT	denotes	an
T11931	3526-3535	VB	denotes	increased
T11932	3536-3541	NN	denotes	level
T11933	3542-3544	IN	denotes	of
T11934	3545-3550	NN	denotes	DNMTs
T11935	3551-3557	IN	denotes	during
T11936	3558-3561	DT	denotes	the
T11937	3562-3574	JJ	denotes	pathogenetic
T11938	3575-3582	NN	denotes	process
T11939	3584-3586	IN	denotes	In
T11940	3587-3592	NN	denotes	colon
T11941	3592-3593	-COMMA-	denotes	,
T11942	3594-3598	NN	denotes	lung
T11943	3599-3602	CC	denotes	and
T11944	3603-3614	JJ	denotes	hematologic
T11945	3615-3627	NN	denotes	malignancies
T11946	3627-3628	-COMMA-	denotes	,
T11947	3629-3643	NN	denotes	overexpression
T11948	3644-3646	IN	denotes	of
T11949	3647-3652	NN	denotes	DNMT1
T11950	3652-3653	-COMMA-	denotes	,
T11951	3654-3655	DT	denotes	a
T11952	3656-3667	NN	denotes	maintenance
T11953	3668-3672	NN	denotes	DNMT
T11954	3672-3673	-COMMA-	denotes	,
T11955	3674-3677	VB	denotes	has
T11956	3678-3682	VB	denotes	been
T11957	3683-3691	VB	denotes	detected
T11958	3692-3693	-LRB-	denotes	(
T11959	3693-3698	CD	denotes	39–41
T11960	3698-3699	-RRB-	denotes	)
T11961	3701-3712	RB	denotes	Furthermore
T11962	3712-3713	-COMMA-	denotes	,
T11963	3714-3716	PRP	denotes	it
T11964	3717-3720	VB	denotes	has
T11965	3721-3725	VB	denotes	been
T11966	3726-3731	VB	denotes	shown
T11967	3732-3736	IN	denotes	that
T11968	3737-3740	NN	denotes	CML
T11969	3741-3746	NN	denotes	cells
T11970	3747-3749	IN	denotes	in
T11971	3750-3753	DT	denotes	the
T11972	3754-3759	JJ	denotes	acute
T11973	3760-3765	NN	denotes	phase
T11974	3766-3775	VB	denotes	exhibited
T11975	3776-3784	JJ	denotes	elevated
T11976	3785-3791	NN	denotes	levels
T11977	3792-3794	IN	denotes	of
T11978	3795-3798	DT	denotes	the
T11979	3799-3804	CD	denotes	three
T11980	3805-3810	VB	denotes	known
T11981	3811-3816	NN	denotes	DNMTs
T11982	3816-3817	-COMMA-	denotes	,
T11983	3818-3823	IN	denotes	while
T11984	3824-3827	NN	denotes	CML
T11985	3828-3833	NN	denotes	cells
T11986	3834-3836	IN	denotes	in
T11987	3837-3844	JJ	denotes	chronic
T11988	3845-3850	NN	denotes	phase
T11989	3851-3860	VB	denotes	expressed
T11990	3861-3867	JJ	denotes	normal
T11991	3868-3874	NN	denotes	levels
T11992	3875-3877	IN	denotes	of
T11993	3878-3883	NN	denotes	DNMTs
T11994	3884-3886	IN	denotes	if
T11995	3887-3895	VB	denotes	compared
T11996	3896-3900	IN	denotes	with
T11997	3901-3907	JJ	denotes	normal
T11998	3908-3912	NN	denotes	bone
T11999	3913-3919	NN	denotes	marrow
T12000	3920-3925	NN	denotes	cells
T12001	3926-3927	-LRB-	denotes	(
T12002	3927-3929	CD	denotes	25
T12003	3929-3930	-RRB-	denotes	)
T12004	3932-3945	RB	denotes	Interestingly
T12005	3945-3946	-COMMA-	denotes	,
T12006	3947-3948	DT	denotes	a
T12007	3949-3957	JJ	denotes	positive
T12008	3958-3969	NN	denotes	correlation
T12009	3970-3977	IN	denotes	between
T12010	3978-3983	NN	denotes	DNMT1
T12011	3984-3994	NN	denotes	expression
T12012	3995-4001	NN	denotes	levels
T12013	4002-4005	CC	denotes	and
T12014	4006-4022	NN	denotes	hypermethylation
T12015	4023-4025	IN	denotes	of
T12016	4026-4034	NN	denotes	p15INK4b
T12017	4035-4038	VB	denotes	has
T12018	4039-4043	VB	denotes	been
T12019	4044-4052	VB	denotes	detected
T12020	4053-4055	IN	denotes	in
T12021	4056-4059	NN	denotes	AML
T12022	4060-4061	-LRB-	denotes	(
T12023	4061-4063	CD	denotes	25
T12024	4063-4064	-RRB-	denotes	)
T12025	4066-4068	IN	denotes	In
T12026	4069-4073	DT	denotes	this
T12027	4074-4078	NN	denotes	work
T12028	4078-4079	-COMMA-	denotes	,
T12029	4080-4082	PRP	denotes	we
T12030	4083-4086	VB	denotes	did
T12031	4087-4090	RB	denotes	not
T12032	4091-4097	VB	denotes	detect
T12033	4098-4109	JJ	denotes	significant
T12034	4110-4114	NN	denotes	mRNA
T12035	4115-4125	NN	denotes	expression
T12036	4126-4137	NN	denotes	differences
T12037	4138-4140	IN	denotes	of
T12038	4141-4149	VB	denotes	selected
T12039	4150-4154	NN	denotes	DNMT
T12040	4155-4157	CC	denotes	or
T12041	4158-4161	NN	denotes	MBP
T12042	4161-4162	-COMMA-	denotes	,
T12043	4163-4169	VB	denotes	making
T12044	4170-4172	PRP	denotes	it
T12045	4173-4175	DT	denotes	an
T12046	4176-4184	JJ	denotes	unlikely
T12047	4185-4190	NN	denotes	cause
T12048	4191-4194	IN	denotes	for
T12049	4195-4198	DT	denotes	the
T12050	4199-4207	VB	denotes	observed
T12051	4208-4219	NN	denotes	methylation
T12052	4220-4223	CC	denotes	and
T12053	4224-4228	RB	denotes	thus
T12054	4229-4234	NN	denotes	IRF-4
T12055	4235-4245	NN	denotes	expression
T12056	4246-4257	NN	denotes	differences
T12057	4258-4260	IN	denotes	in
T12058	4261-4269	NN	denotes	leukemia
T12059	4270-4275	NN	denotes	cells
T12060	4277-4280	DT	denotes	The
T12061	4281-4288	NN	denotes	finding
T12062	4289-4293	IN	denotes	that
T12063	4294-4299	NN	denotes	IRF-4
T12064	4300-4310	NN	denotes	expression
T12065	4311-4313	VB	denotes	is
T12066	4314-4322	VB	denotes	silenced
T12067	4323-4325	IN	denotes	by
T12068	4326-4334	NN	denotes	promoter
T12069	4335-4351	NN	denotes	hypermethylation
T12070	4352-4357	MD	denotes	might
T12071	4358-4367	VB	denotes	represent
T12072	4368-4369	DT	denotes	a
T12073	4370-4379	NN	denotes	mechanism
T12074	4380-4384	WDT	denotes	that
T12075	4385-4393	VB	denotes	accounts
T12076	4394-4397	IN	denotes	for
T12077	4398-4401	DT	denotes	the
T12078	4402-4412	RB	denotes	previously
T12079	4413-4421	VB	denotes	observed
T12080	4422-4426	NN	denotes	loss
T12081	4427-4429	IN	denotes	of
T12082	4430-4435	NN	denotes	IRF-4
T12083	4436-4446	NN	denotes	expression
T12084	4447-4449	IN	denotes	in
T12085	4450-4453	NN	denotes	CML
T12086	4455-4461	RB	denotes	Indeed
T12087	4461-4462	-COMMA-	denotes	,
T12088	4463-4470	JJ	denotes	several
T12089	4471-4479	JJ	denotes	clinical
T12090	4480-4486	NN	denotes	trials
T12091	4487-4491	IN	denotes	with
T12092	4492-4500	NN	denotes	leukemia
T12093	4501-4509	NN	denotes	patients
T12094	4510-4513	CC	denotes	and
T12095	4514-4522	NN	denotes	patients
T12096	4523-4527	IN	denotes	with
T12097	4528-4543	JJ	denotes	myelodysplastic
T12098	4544-4553	NN	denotes	syndromes
T12099	4554-4566	VB	denotes	demonstrated
T12100	4567-4570	DT	denotes	the
T12101	4571-4580	JJ	denotes	potential
T12102	4581-4589	JJ	denotes	clinical
T12103	4590-4597	NN	denotes	benefit
T12104	4598-4600	IN	denotes	of
T12105	4601-4602	DT	denotes	a
T12106	4603-4612	NN	denotes	treatment
T12107	4613-4617	IN	denotes	with
T12108	4618-4631	VB	denotes	demethylating
T12109	4632-4638	NN	denotes	agents
T12110	4639-4640	-LRB-	denotes	(
T12111	4640-4645	CD	denotes	42–45
T12112	4645-4646	-RRB-	denotes	)
T12113	4648-4651	DT	denotes	The
T12114	4652-4662	NN	denotes	expression
T12115	4663-4665	IN	denotes	of
T12116	4666-4673	DT	denotes	another
T12117	4674-4677	NN	denotes	IRF
T12118	4677-4678	-COMMA-	denotes	,
T12119	4679-4682	NN	denotes	IFN
T12120	4683-4692	NN	denotes	consensus
T12121	4693-4701	NN	denotes	sequence
T12122	4702-4709	NN	denotes	binding
T12123	4710-4717	NN	denotes	protein
T12124	4718-4719	-LRB-	denotes	(
T12125	4719-4730	NN	denotes	ICSBP/IRF-8
T12126	4730-4731	-RRB-	denotes	)
T12127	4731-4732	-COMMA-	denotes	,
T12128	4733-4735	VB	denotes	is
T12129	4736-4744	JJ	denotes	impaired
T12130	4745-4747	IN	denotes	in
T12131	4748-4755	JJ	denotes	myeloid
T12132	4756-4765	NN	denotes	leukemias
T12133	4766-4776	RB	denotes	especially
T12134	4777-4780	NN	denotes	CML
T12135	4781-4782	-LRB-	denotes	(
T12136	4782-4790	CD	denotes	27,46,47
T12137	4790-4791	-RRB-	denotes	)
T12138	4793-4796	CC	denotes	But
T12139	4797-4799	IN	denotes	in
T12140	4800-4808	NN	denotes	contrast
T12141	4809-4811	TO	denotes	to
T12142	4812-4817	NN	denotes	IRF-4
T12143	4817-4818	-COMMA-	denotes	,
T12144	4819-4822	DT	denotes	the
T12145	4823-4827	NN	denotes	loss
T12146	4828-4830	IN	denotes	of
T12147	4831-4835	DT	denotes	this
T12148	4836-4839	NN	denotes	IRF
T12149	4840-4845	MD	denotes	could
T12150	4846-4849	RB	denotes	not
T12151	4850-4852	VB	denotes	be
T12152	4853-4861	VB	denotes	reverted
T12153	4862-4864	IN	denotes	in
T12154	4865-4879	JJ	denotes	ICSBP-negative
T12155	4880-4884	NN	denotes	cell
T12156	4885-4890	NN	denotes	lines
T12157	4891-4892	-LRB-	denotes	(
T12158	4892-4896	NN	denotes	EM-2
T12159	4896-4897	-COMMA-	denotes	,
T12160	4898-4904	NN	denotes	CML-T1
T12161	4904-4905	-COMMA-	denotes	,
T12162	4906-4911	NN	denotes	K-562
T12163	4912-4915	CC	denotes	and
T12164	4916-4923	NN	denotes	LAMA-84
T12165	4923-4924	-RRB-	denotes	)
T12166	4925-4927	IN	denotes	by
T12167	4928-4937	NN	denotes	treatment
T12168	4938-4942	IN	denotes	with
T12169	4943-4948	NN	denotes	AzadC
T12170	4949-4950	-LRB-	denotes	(
T12171	4950-4956	NN	denotes	Figure
T12172	4957-4958	CD	denotes	6
T12173	4958-4959	-RRB-	denotes	)
T12174	4960-4963	CC	denotes	and
T12175	4964-4969	NN	denotes	AzadC
T12176	4970-4973	VB	denotes	has
T12177	4974-4976	DT	denotes	no
T12178	4977-4983	NN	denotes	effect
T12179	4984-4986	IN	denotes	on
T12180	4987-4992	NN	denotes	ICSBP
T12181	4993-4999	NN	denotes	levels
T12182	5000-5002	IN	denotes	in
T12183	5003-5017	JJ	denotes	ICSBP-positive
T12184	5018-5023	NN	denotes	U-937
T12185	5024-5029	NN	denotes	cells
T12186	5030-5031	-LRB-	denotes	(
T12187	5031-5037	NN	denotes	Figure
T12188	5038-5039	CD	denotes	6
T12189	5039-5040	-RRB-	denotes	)
T12190	5042-5047	DT	denotes	These
T12191	5048-5052	NN	denotes	data
T12192	5053-5060	VB	denotes	suggest
T12193	5061-5062	DT	denotes	a
T12194	5063-5071	JJ	denotes	distinct
T12195	5072-5082	JJ	denotes	regulatory
T12196	5083-5092	NN	denotes	mechanism
T12197	5093-5096	IN	denotes	for
T12198	5097-5102	DT	denotes	these
T12199	5103-5106	CD	denotes	two
T12200	5107-5111	NN	denotes	IRFs
T12201	5113-5118	NN	denotes	IRF-4
T12202	5118-5119	-COMMA-	denotes	,
T12203	5120-5127	JJ	denotes	similar
T12204	5128-5130	TO	denotes	to
T12205	5131-5135	JJ	denotes	many
T12206	5136-5141	JJ	denotes	other
T12207	5142-5151	JJ	denotes	classical
T12208	5152-5157	NN	denotes	tumor
T12209	5158-5168	NN	denotes	suppressor
T12210	5169-5174	NN	denotes	genes
T12211	5175-5183	NN	denotes	p15INK4b
T12212	5183-5184	-COMMA-	denotes	,
T12213	5185-5193	NN	denotes	p16INK4a
T12214	5194-5196	CC	denotes	or
T12215	5197-5200	NN	denotes	p53
T12216	5200-5201	-COMMA-	denotes	,
T12217	5202-5205	MD	denotes	may
T12218	5206-5210	RB	denotes	thus
T12219	5211-5213	VB	denotes	be
T12220	5214-5215	DT	denotes	a
T12221	5216-5223	NN	denotes	subject
T12222	5224-5226	IN	denotes	of
T12223	5227-5238	NN	denotes	alterations
T12224	5239-5241	IN	denotes	in
T12225	5242-5245	DT	denotes	the
T12226	5246-5254	NN	denotes	promoter
T12227	5255-5266	NN	denotes	methylation
T12228	5267-5273	NN	denotes	status
T12229	5274-5281	VB	denotes	leading
T12230	5282-5284	TO	denotes	to
T12231	5285-5295	NN	denotes	expression
T12232	5296-5303	NN	denotes	changes
T12233	5303-5304	-COMMA-	denotes	,
T12234	5305-5310	WDT	denotes	which
T12235	5311-5316	MD	denotes	might
T12236	5317-5327	VB	denotes	contribute
T12237	5328-5330	TO	denotes	to
T12238	5331-5334	DT	denotes	the
T12239	5335-5345	NN	denotes	initiation
T12240	5346-5352	CC	denotes	and/or
T12241	5353-5364	NN	denotes	progression
T12242	5365-5367	IN	denotes	of
T12243	5368-5374	NN	denotes	cancer
T12244	5376-5381	RB	denotes	Still
T12245	5381-5382	-COMMA-	denotes	,
T12246	5383-5386	DT	denotes	the
T12247	5387-5394	JJ	denotes	obvious
T12248	5395-5405	JJ	denotes	functional
T12249	5406-5415	NN	denotes	diversity
T12250	5416-5418	IN	denotes	of
T12251	5419-5424	NN	denotes	IRF-4
T12252	5425-5432	VB	denotes	remains
T12253	5433-5443	JJ	denotes	remarkable
T12254	5444-5447	CC	denotes	and
T12255	5448-5451	MD	denotes	can
T12256	5451-5454	RB	denotes	not
T12257	5455-5457	VB	denotes	be
T12258	5458-5463	RB	denotes	fully
T12259	5464-5473	VB	denotes	explained
T12260	5474-5476	IN	denotes	by
T12261	5477-5480	DT	denotes	the
T12262	5481-5486	NN	denotes	IRF-4
T12263	5487-5495	NN	denotes	promoter
T12264	5496-5507	NN	denotes	methylation
T12265	5508-5514	NN	denotes	status
T12266	5516-5519	IN	denotes	For
T12267	5520-5527	NN	denotes	example
T12268	5527-5528	-COMMA-	denotes	,
T12269	5529-5534	NN	denotes	IRF-4
T12270	5535-5537	VB	denotes	is
T12271	5538-5547	RB	denotes	primarily
T12272	5548-5553	VB	denotes	known
T12273	5554-5557	IN	denotes	for
T12274	5558-5561	PRP-DOLLAR-	denotes	its
T12275	5562-5571	JJ	denotes	oncogenic
T12276	5572-5580	NN	denotes	features
T12277	5582-5584	IN	denotes	In
T12278	5585-5593	JJ	denotes	multiple
T12279	5594-5601	NN	denotes	myeloma
T12280	5602-5603	-LRB-	denotes	(
T12281	5603-5605	NN	denotes	MM
T12282	5605-5606	-RRB-	denotes	)
T12283	5607-5608	DT	denotes	a
T12284	5609-5622	NN	denotes	translocation
T12285	5623-5625	IN	denotes	on
T12286	5626-5636	NN	denotes	chromosome
T12287	5637-5640	NN	denotes	14q
T12288	5641-5644	VB	denotes	was
T12289	5645-5653	VB	denotes	reported
T12290	5654-5656	TO	denotes	to
T12291	5657-5661	VB	denotes	lead
T12292	5662-5664	TO	denotes	to
T12293	5665-5666	DT	denotes	a
T12294	5667-5673	NN	denotes	fusion
T12295	5674-5678	NN	denotes	gene
T12296	5679-5681	IN	denotes	of
T12297	5682-5696	NN	denotes	immunoglobulin
T12298	5697-5708	NN	denotes	heavy-chain
T12299	5709-5710	-LRB-	denotes	(
T12300	5710-5713	NN	denotes	IgH
T12301	5713-5714	-RRB-	denotes	)
T12302	5715-5718	CC	denotes	and
T12303	5719-5724	NN	denotes	IRF-4
T12304	5725-5734	VB	denotes	resulting
T12305	5735-5737	IN	denotes	in
T12306	5738-5739	DT	denotes	a
T12307	5740-5750	JJ	denotes	subsequent
T12308	5751-5765	NN	denotes	overexpression
T12309	5766-5768	IN	denotes	of
T12310	5769-5774	NN	denotes	IRF-4
T12311	5775-5776	-LRB-	denotes	(
T12312	5776-5781	CD	denotes	48,49
T12313	5781-5782	-RRB-	denotes	)
T12314	5784-5786	IN	denotes	In
T12315	5787-5795	NN	denotes	addition
T12316	5795-5796	-COMMA-	denotes	,
T12317	5797-5805	JJ	denotes	abundant
T12318	5806-5811	NN	denotes	IRF-4
T12319	5812-5822	NN	denotes	expression
T12320	5823-5826	VB	denotes	was
T12321	5827-5832	VB	denotes	found
T12322	5833-5835	TO	denotes	to
T12323	5836-5838	VB	denotes	be
T12324	5839-5840	DT	denotes	a
T12325	5841-5847	NN	denotes	marker
T12326	5848-5851	IN	denotes	for
T12327	5852-5859	JJ	denotes	various
T12328	5860-5867	NN	denotes	subsets
T12329	5868-5870	IN	denotes	of
T12330	5871-5880	NN	denotes	lymphomas
T12331	5880-5881	-COMMA-	denotes	,
T12332	5882-5886	JJ	denotes	such
T12333	5887-5889	IN	denotes	as
T12334	5890-5897	JJ	denotes	diffuse
T12335	5898-5903	JJ	denotes	large
T12336	5904-5910	NN	denotes	B-cell
T12337	5911-5920	NN	denotes	lymphomas
T12338	5920-5921	-COMMA-	denotes	,
T12339	5922-5929	JJ	denotes	primary
T12340	5930-5938	NN	denotes	effusion
T12341	5939-5947	NN	denotes	lymphoma
T12342	5947-5948	-COMMA-	denotes	,
T12343	5949-5952	CC	denotes	and
T12344	5953-5961	JJ	denotes	marginal
T12345	5962-5966	NN	denotes	zone
T12346	5967-5975	NN	denotes	lymphoma
T12347	5975-5976	-COMMA-	denotes	,
T12348	5977-5980	CC	denotes	and
T12349	5981-5986	JJ	denotes	adult
T12350	5987-5993	NN	denotes	T-cell
T12351	5994-6002	NN	denotes	leukemia
T12352	6003-6004	-LRB-	denotes	(
T12353	6004-6015	CD	denotes	11,31,50–52
T12354	6015-6016	-RRB-	denotes	)
T12355	6018-6022	DT	denotes	This
T12356	6023-6028	VB	denotes	draws
T12357	6029-6030	DT	denotes	a
T12358	6031-6035	RB	denotes	more
T12359	6036-6043	JJ	denotes	complex
T12360	6044-6051	NN	denotes	picture
T12361	6052-6054	IN	denotes	of
T12362	6055-6058	DT	denotes	the
T12363	6059-6063	NN	denotes	role
T12364	6064-6066	IN	denotes	of
T12365	6067-6072	NN	denotes	IRF-4
T12366	6074-6089	NN	denotes	Down-regulation
T12367	6090-6092	IN	denotes	of
T12368	6093-6098	NN	denotes	IRF-4
T12369	6099-6102	MD	denotes	may
T12370	6103-6110	VB	denotes	promote
T12371	6111-6125	NN	denotes	leukemogenesis
T12372	6126-6128	IN	denotes	in
T12373	6129-6136	JJ	denotes	myeloid
T12374	6137-6141	NN	denotes	cell
T12375	6142-6149	NN	denotes	context
T12376	6150-6151	-LRB-	denotes	(
T12377	6151-6152	CD	denotes	3
T12378	6152-6153	-RRB-	denotes	)
T12379	6153-6154	-COMMA-	denotes	,
T12380	6155-6160	WDT	denotes	which
T12381	6161-6164	VB	denotes	was
T12382	6165-6173	RB	denotes	recently
T12383	6174-6183	VB	denotes	confirmed
T12384	6184-6186	IN	denotes	in
T12385	6187-6195	NN	denotes	IRF-4−/−
T12386	6196-6204	NN	denotes	ICSBP−/−
T12387	6205-6211	JJ	denotes	double
T12388	6212-6221	JJ	denotes	knock-out
T12389	6222-6226	NN	denotes	mice
T12390	6227-6228	-LRB-	denotes	(
T12391	6228-6230	CD	denotes	53
T12392	6230-6231	-RRB-	denotes	)
T12393	6231-6232	-COMMA-	denotes	,
T12394	6233-6238	IN	denotes	while
T12395	6239-6244	NN	denotes	IRF-4
T12396	6245-6258	NN	denotes	up-regulation
T12397	6259-6262	MD	denotes	may
T12398	6263-6269	VB	denotes	induce
T12399	6270-6271	DT	denotes	a
T12400	6272-6278	NN	denotes	growth
T12401	6279-6288	NN	denotes	advantage
T12402	6289-6291	IN	denotes	in
T12403	6292-6301	NN	denotes	lymphomas
T12404	6302-6304	CC	denotes	or
T12405	6305-6307	NN	denotes	MM
T12406	6308-6309	-LRB-	denotes	(
T12407	6309-6311	CD	denotes	48
T12408	6311-6312	-RRB-	denotes	)
T12409	6314-6319	VB	denotes	Taken
T12410	6320-6328	RB	denotes	together
T12411	6328-6329	-COMMA-	denotes	,
T12412	6330-6333	PRP-DOLLAR-	denotes	our
T12413	6334-6338	NN	denotes	data
T12414	6339-6346	VB	denotes	suggest
T12415	6347-6351	IN	denotes	that
T12416	6352-6357	NN	denotes	IRF-4
T12417	6358-6366	NN	denotes	promoter
T12418	6367-6378	NN	denotes	methylation
T12419	6379-6388	VB	denotes	regulates
T12420	6389-6394	NN	denotes	IRF-4
T12421	6395-6405	NN	denotes	expression
T12422	6405-6406	-COMMA-	denotes	,
T12423	6407-6410	CC	denotes	and
T12424	6411-6415	IN	denotes	that
T12425	6416-6424	JJ	denotes	aberrant
T12426	6425-6435	NN	denotes	expression
T12427	6436-6438	IN	denotes	of
T12428	6439-6444	NN	denotes	IRF-4
T12429	6445-6447	IN	denotes	in
T12430	6448-6455	JJ	denotes	certain
T12431	6456-6461	NN	denotes	types
T12432	6462-6464	IN	denotes	of
T12433	6465-6473	NN	denotes	leukemia
T12434	6474-6477	MD	denotes	may
T12435	6478-6480	VB	denotes	be
T12436	6481-6482	DT	denotes	a
T12437	6483-6494	NN	denotes	consequence
T12438	6495-6497	IN	denotes	of
T12439	6498-6503	NN	denotes	IRF-4
T12440	6504-6512	NN	denotes	promoter
T12441	6513-6529	NN	denotes	hypermethylation
R10000	T12099	T12086	arg1Of	demonstrated,Indeed
R10001	T12099	T12087	arg1Of	demonstrated,","
R10002	T12103	T12099	arg2Of	benefit,demonstrated
R10003	T12103	T12100	arg1Of	benefit,the
R10004	T12103	T12101	arg1Of	benefit,potential
R10005	T12103	T12102	arg1Of	benefit,clinical
R10006	T12103	T12104	arg1Of	benefit,of
R10007	T12106	T12104	arg2Of	treatment,of
R10008	T12106	T12105	arg1Of	treatment,a
R10009	T12106	T12107	arg1Of	treatment,with
R10010	T12109	T12107	arg2Of	agents,with
R10011	T12109	T12108	arg1Of	agents,demethylating
R10012	T12109	T12110	arg1Of	agents,(
R10013	T12111	T12110	arg2Of	42–45,(
R10014	T12112	T12110	arg3Of	),(
R10015	T12114	T12113	arg1Of	expression,The
R10016	T12114	T12115	arg1Of	expression,of
R10017	T12114	T12128	arg1Of	expression,is
R10018	T12114	T12129	arg1Of	expression,impaired
R10019	T12117	T12116	arg1Of	IRF,another
R10020	T12117	T12118	arg1Of	IRF,","
R10021	T12118	T12115	arg2Of	",",of
R10022	T12123	T12118	arg2Of	protein,","
R10023	T12123	T12119	arg1Of	protein,IFN
R10024	T12123	T12120	arg1Of	protein,consensus
R10025	T12123	T12121	arg1Of	protein,sequence
R10026	T12123	T12122	arg1Of	protein,binding
R10027	T12123	T12124	arg1Of	protein,(
R10028	T12125	T12124	arg2Of	ICSBP/IRF-8,(
R10029	T12126	T12124	arg3Of	),(
R10030	T12128	T12127	arg1Of	is,","
R10031	T12129	T12128	arg2Of	impaired,is
R10032	T12129	T12130	arg1Of	impaired,in
R10033	T12134	T12130	arg2Of	CML,in
R10034	T12134	T12131	arg1Of	CML,myeloid
R10035	T12134	T12132	arg1Of	CML,leukemias
R10036	T12134	T12133	arg1Of	CML,especially
R10037	T12134	T12135	arg1Of	CML,(
R10038	T12136	T12135	arg2Of	"27,46,47",(
R10039	T12137	T12135	arg3Of	),(
R10040	T12140	T12139	arg2Of	contrast,in
R10041	T12140	T12141	arg1Of	contrast,to
R10042	T12142	T12141	arg2Of	IRF-4,to
R10043	T12145	T12144	arg1Of	loss,the
R10044	T12145	T12146	arg1Of	loss,of
R10045	T12145	T12149	arg1Of	loss,could
R10046	T12145	T12151	arg1Of	loss,be
R10047	T12145	T12152	arg2Of	loss,reverted
R10048	T12148	T12146	arg2Of	IRF,of
R10049	T12148	T12147	arg1Of	IRF,this
R10050	T12152	T12149	arg2Of	reverted,could
R10051	T12152	T12150	arg1Of	reverted,not
R10052	T12152	T12151	arg2Of	reverted,be
R10053	T12152	T12153	arg1Of	reverted,in
R10054	T12152	T12166	arg1Of	reverted,by
R10055	T12152	T12174	arg1Of	reverted,and
R10056	T12156	T12153	arg2Of	lines,in
R10057	T12156	T12154	arg1Of	lines,ICSBP-negative
R10058	T12156	T12155	arg1Of	lines,cell
R10059	T12156	T12157	arg1Of	lines,(
R10060	T12158	T12159	arg1Of	EM-2,","
R10061	T12159	T12161	arg1Of	",",","
R10062	T12160	T12159	arg2Of	CML-T1,","
R10063	T12161	T12163	arg1Of	",",and
R10064	T12162	T12161	arg2Of	K-562,","
R10065	T12163	T12157	arg2Of	and,(
R10066	T12164	T12163	arg2Of	LAMA-84,and
R10067	T12165	T12157	arg3Of	),(
R10068	T12167	T12166	arg2Of	treatment,by
R10069	T12167	T12168	arg1Of	treatment,with
R10070	T12169	T12168	arg2Of	AzadC,with
R10071	T12169	T12170	arg1Of	AzadC,(
R10072	T12171	T12170	arg2Of	Figure,(
R10073	T12171	T12172	arg1Of	Figure,6
R10074	T12173	T12170	arg3Of	),(
R10075	T12174	T12138	arg1Of	and,But
R10076	T12174	T12139	arg1Of	and,in
R10077	T12174	T12143	arg1Of	and,","
R10078	T12175	T12176	arg1Of	AzadC,has
R10079	T12176	T12174	arg2Of	has,and
R10080	T12176	T12179	arg1Of	has,on
R10081	T12178	T12176	arg2Of	effect,has
R10082	T12178	T12177	arg1Of	effect,no
R10083	T12181	T12179	arg2Of	levels,on
R10084	T12181	T12180	arg1Of	levels,ICSBP
R10085	T12181	T12182	arg1Of	levels,in
R10086	T12185	T12182	arg2Of	cells,in
R10087	T12185	T12183	arg1Of	cells,ICSBP-positive
R10088	T12185	T12184	arg1Of	cells,U-937
R10089	T12185	T12186	arg1Of	cells,(
R10090	T12187	T12186	arg2Of	Figure,(
R10091	T12187	T12188	arg1Of	Figure,6
R10092	T12189	T12186	arg3Of	),(
R10093	T12191	T12190	arg1Of	data,These
R10094	T12191	T12192	arg1Of	data,suggest
R10095	T12196	T12192	arg2Of	mechanism,suggest
R10096	T12196	T12193	arg1Of	mechanism,a
R10097	T12196	T12194	arg1Of	mechanism,distinct
R10098	T12196	T12195	arg1Of	mechanism,regulatory
R10099	T12196	T12197	arg1Of	mechanism,for
R10100	T12200	T12197	arg2Of	IRFs,for
R10101	T12200	T12198	arg1Of	IRFs,these
R10102	T12200	T12199	arg1Of	IRFs,two
R10103	T12201	T12202	arg1Of	IRF-4,","
R10104	T12201	T12203	arg1Of	IRF-4,similar
R10105	T12203	T12204	arg1Of	similar,to
R10106	T12210	T12204	arg2Of	genes,to
R10107	T12210	T12205	arg1Of	genes,many
R10108	T12210	T12206	arg1Of	genes,other
R10109	T12210	T12207	arg1Of	genes,classical
R10110	T12210	T12208	arg1Of	genes,tumor
R10111	T12210	T12209	arg1Of	genes,suppressor
R10112	T12211	T12212	arg1Of	p15INK4b,","
R10113	T12212	T12214	arg1Of	",",or
R10114	T12213	T12212	arg2Of	p16INK4a,","
R10115	T12214	T12201	arg1Of	or,IRF-4
R10116	T12214	T12217	arg1Of	or,may
R10117	T12214	T12219	arg1Of	or,be
R10118	T12215	T12214	arg2Of	p53,or
R10119	T12219	T12216	arg1Of	be,","
R10120	T12219	T12217	arg2Of	be,may
R10121	T12219	T12218	arg1Of	be,thus
R10122	T12221	T12219	arg2Of	subject,be
R10123	T12221	T12220	arg1Of	subject,a
R10124	T12221	T12222	arg1Of	subject,of
R10125	T12221	T12224	arg1Of	subject,in
R10126	T12221	T12233	arg1Of	subject,","
R10127	T12221	T12234	arg1Of	subject,which
R10128	T12221	T12235	arg1Of	subject,might
R10129	T12221	T12236	arg1Of	subject,contribute
R10130	T12223	T12222	arg2Of	alterations,of
R10131	T12228	T12224	arg2Of	status,in
R10132	T12228	T12225	arg1Of	status,the
R10133	T12228	T12226	arg1Of	status,promoter
R10134	T12228	T12227	arg1Of	status,methylation
R10135	T12228	T12229	arg1Of	status,leading
R10136	T12229	T12230	arg1Of	leading,to
R10137	T12232	T12230	arg2Of	changes,to
R10138	T12232	T12231	arg1Of	changes,expression
R10139	T12236	T12235	arg2Of	contribute,might
R10140	T12236	T12237	arg1Of	contribute,to
R10141	T12239	T12240	arg1Of	initiation,and/or
R10142	T12240	T12237	arg2Of	and/or,to
R10143	T12240	T12238	arg1Of	and/or,the
R10144	T12240	T12242	arg1Of	and/or,of
R10145	T12241	T12240	arg2Of	progression,and/or
R10146	T12243	T12242	arg2Of	cancer,of
R10147	T12249	T12246	arg1Of	diversity,the
R10148	T12249	T12247	arg1Of	diversity,obvious
R10149	T12249	T12248	arg1Of	diversity,functional
R10150	T12249	T12250	arg1Of	diversity,of
R10151	T12249	T12252	arg1Of	diversity,remains
R10152	T12249	T12253	arg1Of	diversity,remarkable
R10153	T12249	T12255	arg1Of	diversity,can
R10154	T12249	T12257	arg1Of	diversity,be
R10155	T12249	T12259	arg2Of	diversity,explained
R10156	T12251	T12250	arg2Of	IRF-4,of
R10157	T12252	T12254	arg1Of	remains,and
R10158	T12253	T12252	arg2Of	remarkable,remains
R10159	T12254	T12244	arg1Of	and,Still
R10160	T12254	T12245	arg1Of	and,","
R10161	T12259	T12254	arg2Of	explained,and
R10162	T12259	T12255	arg2Of	explained,can
R10163	T12259	T12256	arg1Of	explained,not
R10164	T12259	T12257	arg2Of	explained,be
R10165	T12259	T12258	arg1Of	explained,fully
R10166	T12265	T12259	arg1Of	status,explained
R10167	T12265	T12260	arg2Of	status,by
R10168	T12265	T12261	arg1Of	status,the
R10169	T12265	T12262	arg1Of	status,IRF-4
R10170	T12265	T12263	arg1Of	status,promoter
R10171	T12265	T12264	arg1Of	status,methylation
R10172	T12267	T12266	arg2Of	example,For
R10173	T12269	T12270	arg1Of	IRF-4,is
R10174	T12269	T12272	arg2Of	IRF-4,known
R10175	T12272	T12266	arg1Of	known,For
R10176	T12272	T12268	arg1Of	known,","
R10177	T12272	T12270	arg2Of	known,is
R10178	T12272	T12271	arg1Of	known,primarily
R10179	T12272	T12273	arg1Of	known,for
R10180	T12276	T12273	arg2Of	features,for
R10181	T12276	T12274	arg1Of	features,its
R10182	T12276	T12275	arg1Of	features,oncogenic
R10183	T12279	T12277	arg2Of	myeloma,In
R10184	T12279	T12278	arg1Of	myeloma,multiple
R10185	T12279	T12280	arg1Of	myeloma,(
R10186	T12281	T12280	arg2Of	MM,(
R10187	T12282	T12280	arg3Of	),(
R10188	T12284	T12283	arg1Of	translocation,a
R10189	T12284	T12285	arg1Of	translocation,on
R10190	T12284	T12288	arg1Of	translocation,was
R10191	T12284	T12289	arg2Of	translocation,reported
R10192	T12284	T12291	arg1Of	translocation,lead
R10193	T12287	T12285	arg2Of	14q,on
R10194	T12287	T12286	arg1Of	14q,chromosome
R10195	T12289	T12277	arg1Of	reported,In
R10196	T12289	T12288	arg2Of	reported,was
R10197	T12289	T12304	modOf	reported,resulting
R10198	T12291	T12289	arg3Of	lead,reported
R10199	T12291	T12290	arg1Of	lead,to
R10200	T12291	T12292	arg1Of	lead,to
R10201	T12295	T12292	arg2Of	gene,to
R10202	T12295	T12293	arg1Of	gene,a
R10203	T12295	T12294	arg1Of	gene,fusion
R10204	T12295	T12296	arg1Of	gene,of
R10205	T12298	T12297	arg1Of	heavy-chain,immunoglobulin
R10206	T12298	T12299	arg1Of	heavy-chain,(
R10207	T12298	T12302	arg1Of	heavy-chain,and
R10208	T12300	T12299	arg2Of	IgH,(
R10209	T12301	T12299	arg3Of	),(
R10210	T12302	T12296	arg2Of	and,of
R10211	T12303	T12302	arg2Of	IRF-4,and
R10212	T12304	T12305	arg1Of	resulting,in
R10213	T12308	T12305	arg2Of	overexpression,in
R10214	T12308	T12306	arg1Of	overexpression,a
R10215	T12308	T12307	arg1Of	overexpression,subsequent
R10216	T12308	T12309	arg1Of	overexpression,of
R10217	T12310	T12309	arg2Of	IRF-4,of
R10218	T12310	T12311	arg1Of	IRF-4,(
R10219	T12312	T12311	arg2Of	"48,49",(
R10220	T12313	T12311	arg3Of	),(
R10221	T12315	T12314	arg2Of	addition,In
R10222	T12319	T12317	arg1Of	expression,abundant
R10223	T12319	T12318	arg1Of	expression,IRF-4
R10224	T12319	T12320	arg1Of	expression,was
R10225	T12319	T12321	arg2Of	expression,found
R10226	T12319	T12323	arg1Of	expression,be
R10227	T12321	T12314	arg1Of	found,In
R10228	T12321	T12316	arg1Of	found,","
R10229	T12321	T12320	arg2Of	found,was
R10230	T12323	T12321	arg3Of	be,found
R10231	T12323	T12322	arg1Of	be,to
R10232	T12325	T12323	arg2Of	marker,be
R10233	T12325	T12324	arg1Of	marker,a
R10234	T12325	T12326	arg1Of	marker,for
R10235	T12328	T12326	arg2Of	subsets,for
R10236	T12328	T12327	arg1Of	subsets,various
R10237	T12328	T12329	arg1Of	subsets,of
R10238	T12328	T12331	arg1Of	subsets,","
R10239	T12328	T12333	arg1Of	subsets,as
R10240	T12330	T12329	arg2Of	lymphomas,of
R10241	T12333	T12332	arg1Of	as,such
R10242	T12337	T12334	arg1Of	lymphomas,diffuse
R10243	T12337	T12335	arg1Of	lymphomas,large
R10244	T12337	T12336	arg1Of	lymphomas,B-cell
R10245	T12337	T12338	arg1Of	lymphomas,","
R10246	T12338	T12343	arg1Of	",",and
R10247	T12341	T12338	arg2Of	lymphoma,","
R10248	T12341	T12339	arg1Of	lymphoma,primary
R10249	T12341	T12340	arg1Of	lymphoma,effusion
R10250	T12343	T12342	arg1Of	and,","
R10251	T12343	T12348	arg1Of	and,and
R10252	T12346	T12343	arg2Of	lymphoma,and
R10253	T12346	T12344	arg1Of	lymphoma,marginal
R10254	T12346	T12345	arg1Of	lymphoma,zone
R10255	T12348	T12333	arg2Of	and,as
R10256	T12348	T12347	arg1Of	and,","
R10257	T12351	T12348	arg2Of	leukemia,and
R10258	T12351	T12349	arg1Of	leukemia,adult
R10259	T12351	T12350	arg1Of	leukemia,T-cell
R10260	T12351	T12352	arg1Of	leukemia,(
R10261	T12353	T12352	arg2Of	"11,31,50–52",(
R10262	T12354	T12352	arg3Of	),(
R10263	T12355	T12356	arg1Of	This,draws
R10264	T12359	T12358	arg1Of	complex,more
R10265	T12360	T12356	arg2Of	picture,draws
R10266	T12360	T12357	arg1Of	picture,a
R10267	T12360	T12359	arg1Of	picture,complex
R10268	T12360	T12361	arg1Of	picture,of
R10269	T12363	T12361	arg2Of	role,of
R10270	T12363	T12362	arg1Of	role,the
R10271	T12363	T12364	arg1Of	role,of
R10272	T12365	T12364	arg2Of	IRF-4,of
R10273	T12366	T12367	arg1Of	Down-regulation,of
R10274	T12366	T12369	arg1Of	Down-regulation,may
R10275	T12366	T12370	arg1Of	Down-regulation,promote
R10276	T12368	T12367	arg2Of	IRF-4,of
R10277	T12370	T12369	arg2Of	promote,may
R10278	T12370	T12372	arg1Of	promote,in
R10279	T12371	T12370	arg2Of	leukemogenesis,promote
R10280	T12375	T12372	arg2Of	context,in
R10281	T12375	T12373	arg1Of	context,myeloid
R10282	T12375	T12374	arg1Of	context,cell
R10283	T12375	T12376	arg1Of	context,(
R10284	T12375	T12379	arg1Of	context,","
R10285	T12375	T12380	arg1Of	context,which
R10286	T12375	T12381	arg1Of	context,was
R10287	T12375	T12383	arg2Of	context,confirmed
R10288	T12377	T12376	arg2Of	3,(
R10289	T12378	T12376	arg3Of	),(
R10290	T12383	T12381	arg2Of	confirmed,was
R10291	T12383	T12382	arg1Of	confirmed,recently
R10292	T12383	T12384	arg1Of	confirmed,in
R10293	T12383	T12393	arg1Of	confirmed,","
R10294	T12383	T12394	arg1Of	confirmed,while
R10295	T12389	T12384	arg2Of	mice,in
R10296	T12389	T12385	arg1Of	mice,IRF-4−/−
R10297	T12389	T12386	arg1Of	mice,ICSBP−/−
R10298	T12389	T12387	arg1Of	mice,double
R10299	T12389	T12388	arg1Of	mice,knock-out
R10300	T12389	T12390	arg1Of	mice,(
R10301	T12391	T12390	arg2Of	53,(
R10302	T12392	T12390	arg3Of	),(
R10303	T12396	T12395	arg1Of	up-regulation,IRF-4
R10304	T12396	T12397	arg1Of	up-regulation,may
R10305	T12396	T12398	arg1Of	up-regulation,induce
R10306	T12398	T12394	arg2Of	induce,while
R10307	T12398	T12397	arg2Of	induce,may
R10308	T12398	T12402	arg1Of	induce,in
R10309	T12401	T12398	arg2Of	advantage,induce
R10310	T12401	T12399	arg1Of	advantage,a
R10311	T12401	T12400	arg1Of	advantage,growth
R10312	T12403	T12404	arg1Of	lymphomas,or
R10313	T12404	T12402	arg2Of	or,in
R10314	T12405	T12404	arg2Of	MM,or
R10315	T12405	T12406	arg1Of	MM,(
R10316	T12407	T12406	arg2Of	48,(
R10317	T12408	T12406	arg3Of	),(
R10318	T12409	T12410	arg1Of	Taken,together
R10319	T12413	T12412	arg1Of	data,our
R10320	T12413	T12414	arg1Of	data,suggest
R10321	T12414	T12409	modOf	suggest,Taken
R10322	T12414	T12411	arg1Of	suggest,","
R10323	T12418	T12416	arg1Of	methylation,IRF-4
R10324	T12418	T12417	arg1Of	methylation,promoter
R10325	T12418	T12419	arg1Of	methylation,regulates
R10326	T12419	T12415	arg1Of	regulates,that
R10327	T12419	T12423	arg1Of	regulates,and
R10328	T12421	T12419	arg2Of	expression,regulates
R10329	T12421	T12420	arg1Of	expression,IRF-4
R10330	T12423	T12414	arg2Of	and,suggest
R10331	T12423	T12422	arg1Of	and,","
R10332	T12424	T12423	arg2Of	that,and
R10333	T12426	T12425	arg1Of	expression,aberrant
R10334	T12426	T12427	arg1Of	expression,of
R10335	T12426	T12429	arg1Of	expression,in
R10336	T12426	T12434	arg1Of	expression,may
R10337	T12426	T12435	arg1Of	expression,be
R10338	T12428	T12427	arg2Of	IRF-4,of
R10339	T12431	T12429	arg2Of	types,in
R10340	T12431	T12430	arg1Of	types,certain
R10341	T12431	T12432	arg1Of	types,of
R10342	T12433	T12432	arg2Of	leukemia,of
R10343	T12435	T12424	arg2Of	be,that
R10344	T12435	T12434	arg2Of	be,may
R10345	T12437	T12435	arg2Of	consequence,be
R10346	T12437	T12436	arg1Of	consequence,a
R10347	T12437	T12438	arg1Of	consequence,of
R10348	T12441	T12438	arg2Of	hypermethylation,of
R10349	T12441	T12439	arg1Of	hypermethylation,IRF-4
R10350	T12441	T12440	arg1Of	hypermethylation,promoter
R9224	T11348	T11346	arg1Of	lesions,Many
R9225	T11348	T11347	arg1Of	lesions,genetic
R9226	T11348	T11349	arg1Of	lesions,are
R9227	T11348	T11350	arg2Of	lesions,known
R9228	T11348	T11352	arg1Of	lesions,influence
R9229	T11350	T11349	arg2Of	known,are
R9230	T11352	T11350	arg3Of	influence,known
R9231	T11352	T11351	arg1Of	influence,to
R9232	T11354	T11352	arg2Of	expression,influence
R9233	T11354	T11353	arg1Of	expression,gene
R9234	T11354	T11355	arg1Of	expression,of
R9235	T11358	T11355	arg2Of	genes,of
R9236	T11358	T11356	arg1Of	genes,tumor
R9237	T11358	T11357	arg1Of	genes,suppressor
R9238	T11360	T11361	arg1Of	mutations,and
R9239	T11361	T11365	arg1Of	and,have
R9240	T11362	T11363	arg1Of	deletions,or
R9241	T11363	T11361	arg2Of	or,and
R9242	T11364	T11363	arg2Of	insertions,or
R9243	T11365	T11359	arg2Of	have,Whereas
R9244	T11367	T11365	arg2Of	effects,have
R9245	T11367	T11366	arg1Of	effects,permanent
R9246	T11370	T11369	arg1Of	mechanisms,reversible
R9247	T11370	T11371	arg1Of	mechanisms,are
R9248	T11371	T11359	arg1Of	are,Whereas
R9249	T11371	T11368	arg1Of	are,","
R9250	T11371	T11382	arg1Of	are,","
R9251	T11371	T11383	arg1Of	are,respectively
R9252	T11373	T11372	arg1Of	methylation,gene
R9253	T11373	T11375	arg1Of	methylation,or
R9254	T11375	T11371	arg2Of	or,are
R9255	T11375	T11374	arg1Of	or,","
R9256	T11375	T11379	arg1Of	or,of
R9257	T11376	T11377	arg1Of	expression,and
R9258	T11377	T11375	arg2Of	and,or
R9259	T11378	T11377	arg2Of	activation,and
R9260	T11381	T11379	arg2Of	factors,of
R9261	T11381	T11380	arg1Of	factors,transcription
R9262	T11384	T11385	arg1Of	We,studied
R9263	T11384	T11398	arg1Of	We,focused
R9264	T11385	T11396	arg1Of	studied,and
R9265	T11388	T11385	arg2Of	cause,studied
R9266	T11388	T11386	arg1Of	cause,a
R9267	T11388	T11387	arg1Of	cause,putative
R9268	T11388	T11389	arg1Of	cause,for
R9269	T11392	T11389	arg2Of	expression,for
R9270	T11392	T11390	arg1Of	expression,absent
R9271	T11392	T11391	arg1Of	expression,IRF-4
R9272	T11392	T11393	arg1Of	expression,in
R9273	T11395	T11393	arg2Of	cells,in
R9274	T11395	T11394	arg1Of	cells,leukemia
R9275	T11398	T11396	arg2Of	focused,and
R9276	T11398	T11397	arg1Of	focused,first
R9277	T11398	T11399	arg1Of	focused,on
R9278	T11401	T11399	arg2Of	aberrations,on
R9279	T11401	T11400	arg1Of	aberrations,genetic
R9280	T11401	T11402	arg1Of	aberrations,of
R9281	T11404	T11402	arg2Of	promoter,of
R9282	T11404	T11403	arg1Of	promoter,the
R9283	T11405	T11406	arg1Of	We,observed
R9284	T11406	T11424	arg1Of	observed,:
R9285	T11409	T11406	arg2Of	alterations,observed
R9286	T11409	T11407	arg1Of	alterations,no
R9287	T11409	T11408	arg1Of	alterations,genetic
R9288	T11409	T11410	arg1Of	alterations,in
R9289	T11413	T11410	arg2Of	promoter,in
R9290	T11413	T11411	arg1Of	promoter,the
R9291	T11413	T11412	arg1Of	promoter,IRF-4
R9292	T11413	T11414	arg1Of	promoter,","
R9293	T11413	T11415	arg1Of	promoter,which
R9294	T11413	T11416	arg1Of	promoter,can
R9295	T11413	T11417	arg1Of	promoter,account
R9296	T11417	T11416	arg2Of	account,can
R9297	T11417	T11418	arg1Of	account,for
R9298	T11420	T11418	arg2Of	lack,for
R9299	T11420	T11419	arg1Of	lack,the
R9300	T11420	T11421	arg1Of	lack,of
R9301	T11423	T11421	arg2Of	expression,of
R9302	T11423	T11422	arg1Of	expression,IRF-4
R9303	T11429	T11425	arg1Of	changes,The
R9304	T11429	T11426	arg2Of	changes,detected
R9305	T11429	T11427	arg1Of	changes,base
R9306	T11429	T11428	arg1Of	changes,pair
R9307	T11429	T11430	arg1Of	changes,at
R9308	T11429	T11437	arg1Of	changes,","
R9309	T11429	T11438	arg1Of	changes,at
R9310	T11429	T11446	arg1Of	changes,at
R9311	T11429	T11453	arg1Of	changes,are
R9312	T11432	T11430	arg2Of	−1081,at
R9313	T11432	T11431	arg1Of	−1081,position
R9314	T11432	T11433	arg1Of	−1081,(
R9315	T11435	T11433	arg2Of	substitution,(
R9316	T11435	T11434	arg1Of	substitution,T→C
R9317	T11436	T11433	arg3Of	),(
R9318	T11438	T11445	arg1Of	at,and
R9319	T11439	T11438	arg2Of	position,at
R9320	T11439	T11440	arg1Of	position,−1068
R9321	T11439	T11441	arg1Of	position,(
R9322	T11443	T11441	arg2Of	substitution,(
R9323	T11443	T11442	arg1Of	substitution,A→C
R9324	T11444	T11441	arg3Of	),(
R9325	T11446	T11445	arg2Of	at,and
R9326	T11447	T11446	arg2Of	position,at
R9327	T11447	T11448	arg1Of	position,−116
R9328	T11447	T11449	arg1Of	position,(
R9329	T11451	T11449	arg2Of	substitution,(
R9330	T11451	T11450	arg1Of	substitution,A→C
R9331	T11452	T11449	arg3Of	),(
R9332	T11453	T11472	arg1Of	are,whereas
R9333	T11455	T11456	arg1Of	responsible,for
R9334	T11455	T11469	arg1Of	responsible,and
R9335	T11458	T11456	arg2Of	IRF-4-expression,for
R9336	T11458	T11457	arg1Of	IRF-4-expression,absent
R9337	T11458	T11459	arg1Of	IRF-4-expression,since
R9338	T11463	T11460	arg1Of	mutations,the
R9339	T11463	T11461	arg1Of	mutations,first
R9340	T11463	T11462	arg1Of	mutations,two
R9341	T11463	T11464	arg1Of	mutations,were
R9342	T11463	T11465	arg2Of	mutations,found
R9343	T11465	T11459	arg2Of	found,since
R9344	T11465	T11464	arg2Of	found,were
R9345	T11465	T11467	arg1Of	found,in
R9346	T11467	T11466	arg1Of	in,both
R9347	T11468	T11467	arg2Of	IRF-4-positive,in
R9348	T11470	T11469	arg2Of	-negative,and
R9349	T11471	T11453	arg2Of	cells,are
R9350	T11471	T11454	arg1Of	cells,unlikely
R9351	T11471	T11455	arg1Of	cells,responsible
R9352	T11471	T11470	arg1Of	cells,-negative
R9353	T11475	T11473	arg1Of	change,the
R9354	T11475	T11474	arg1Of	change,latter
R9355	T11475	T11476	arg1Of	change,was
R9356	T11475	T11478	arg2Of	change,detected
R9357	T11475	T11487	arg1Of	change,may
R9358	T11475	T11489	arg1Of	change,be
R9359	T11478	T11476	arg2Of	detected,was
R9360	T11478	T11477	arg1Of	detected,not
R9361	T11478	T11479	arg1Of	detected,consistently
R9362	T11478	T11480	arg1Of	detected,in
R9363	T11478	T11486	arg1Of	detected,and
R9364	T11482	T11483	arg1Of	IRF-4-negative,or
R9365	T11484	T11483	arg2Of	-positive,or
R9366	T11485	T11480	arg2Of	cells,in
R9367	T11485	T11481	arg1Of	cells,all
R9368	T11485	T11482	arg1Of	cells,IRF-4-negative
R9369	T11485	T11484	arg1Of	cells,-positive
R9370	T11486	T11472	arg2Of	and,whereas
R9371	T11489	T11486	arg2Of	be,and
R9372	T11489	T11487	arg2Of	be,may
R9373	T11489	T11488	arg1Of	be,thus
R9374	T11491	T11489	arg2Of	polymorphism,be
R9375	T11491	T11490	arg1Of	polymorphism,a
R9376	T11494	T11492	arg1Of	substitutions,All
R9377	T11494	T11493	arg1Of	substitutions,three
R9378	T11494	T11495	arg1Of	substitutions,did
R9379	T11494	T11497	arg1Of	substitutions,change
R9380	T11494	T11510	arg1Of	substitutions,do
R9381	T11494	T11512	arg1Of	substitutions,affect
R9382	T11497	T11495	arg2Of	change,did
R9383	T11497	T11496	arg1Of	change,not
R9384	T11497	T11508	arg1Of	change,and
R9385	T11504	T11497	arg2Of	sites,change
R9386	T11504	T11498	arg1Of	sites,any
R9387	T11504	T11499	arg1Of	sites,known
R9388	T11504	T11500	arg1Of	sites,putative
R9389	T11504	T11501	arg1Of	sites,transcription
R9390	T11504	T11502	arg1Of	sites,factor
R9391	T11504	T11503	arg1Of	sites,binding
R9392	T11504	T11505	arg1Of	sites,(
R9393	T11506	T11505	arg2Of	"30,31",(
R9394	T11507	T11505	arg3Of	),(
R9395	T11512	T11508	arg2Of	affect,and
R9396	T11512	T11509	arg1Of	affect,also
R9397	T11512	T11510	arg2Of	affect,do
R9398	T11512	T11511	arg1Of	affect,not
R9399	T11515	T11514	arg1Of	sites,restriction
R9400	T11515	T11516	arg1Of	sites,or
R9401	T11516	T11512	arg2Of	or,affect
R9402	T11516	T11513	arg1Of	or,any
R9403	T11516	T11520	arg1Of	or,of
R9404	T11519	T11516	arg2Of	sites,or
R9405	T11519	T11517	arg1Of	sites,primer
R9406	T11519	T11518	arg1Of	sites,binding
R9407	T11523	T11520	arg2Of	assays,of
R9408	T11523	T11521	arg1Of	assays,the
R9409	T11523	T11522	arg2Of	assays,used
R9410	T11528	T11526	arg1Of	variations,permanent
R9411	T11528	T11527	arg1Of	variations,genetic
R9412	T11528	T11529	arg1Of	variations,in
R9413	T11528	T11534	arg1Of	variations,","
R9414	T11528	T11536	arg1Of	variations,as
R9415	T11528	T11543	arg1Of	variations,have
R9416	T11528	T11545	arg1Of	variations,been
R9417	T11528	T11546	arg2Of	variations,excluded
R9418	T11533	T11529	arg2Of	sequence,in
R9419	T11533	T11530	arg1Of	sequence,the
R9420	T11533	T11531	arg1Of	sequence,IRF-4
R9421	T11533	T11532	arg1Of	sequence,coding
R9422	T11536	T11535	arg1Of	as,such
R9423	T11537	T11538	arg1Of	deletions,or
R9424	T11538	T11536	arg2Of	or,as
R9425	T11538	T11540	arg1Of	or,resulting
R9426	T11539	T11538	arg2Of	mutations,or
R9427	T11540	T11541	arg1Of	resulting,in
R9428	T11542	T11541	arg2Of	stop-codons,in
R9429	T11546	T11524	arg1Of	excluded,However
R9430	T11546	T11525	arg1Of	excluded,","
R9431	T11546	T11543	arg2Of	excluded,have
R9432	T11546	T11544	arg1Of	excluded,not
R9433	T11546	T11545	arg2Of	excluded,been
R9434	T11549	T11546	arg1Of	analysis,excluded
R9435	T11549	T11547	arg2Of	analysis,by
R9436	T11549	T11548	arg1Of	analysis,sequence
R9437	T11552	T11551	arg1Of	expression,IRF-4
R9438	T11552	T11553	arg1Of	expression,in
R9439	T11552	T11558	arg1Of	expression,can
R9440	T11552	T11559	arg1Of	expression,be
R9441	T11552	T11560	arg2Of	expression,induced
R9442	T11555	T11554	arg1Of	lines,cell
R9443	T11555	T11556	arg1Of	lines,and
R9444	T11556	T11553	arg2Of	and,in
R9445	T11557	T11556	arg2Of	CML,and
R9446	T11560	T11550	arg2Of	induced,Since
R9447	T11560	T11558	arg2Of	induced,can
R9448	T11560	T11559	arg2Of	induced,be
R9449	T11560	T11570	arg1Of	induced,","
R9450	T11560	T11571	arg1Of	induced,respectively
R9451	T11562	T11563	arg1Of	demethylation,and
R9452	T11563	T11560	arg1Of	and,induced
R9453	T11563	T11561	arg2Of	and,by
R9454	T11566	T11563	arg2Of	therapy,and
R9455	T11566	T11564	arg1Of	therapy,successful
R9456	T11566	T11565	arg1Of	therapy,IFN-α
R9457	T11566	T11567	arg1Of	therapy,(
R9458	T11568	T11567	arg2Of	3,(
R9459	T11569	T11567	arg3Of	),(
R9460	T11574	T11573	arg1Of	existence,the
R9461	T11574	T11575	arg1Of	existence,of
R9462	T11574	T11579	arg1Of	existence,seems
R9463	T11574	T11580	arg1Of	existence,unlikely
R9464	T11578	T11575	arg2Of	aberrations,of
R9465	T11578	T11576	arg1Of	aberrations,such
R9466	T11578	T11577	arg1Of	aberrations,genetic
R9467	T11579	T11550	arg1Of	seems,Since
R9468	T11579	T11572	arg1Of	seems,","
R9469	T11580	T11579	arg2Of	unlikely,seems
R9470	T11581	T11583	arg1Of	We,investigated
R9471	T11583	T11582	arg1Of	investigated,then
R9472	T11587	T11586	arg1Of	described,previously
R9473	T11588	T11585	arg1Of	down-regulation,the
R9474	T11588	T11587	arg1Of	down-regulation,described
R9475	T11588	T11589	arg1Of	down-regulation,of
R9476	T11588	T11596	arg1Of	down-regulation,was
R9477	T11588	T11597	arg1Of	down-regulation,due
R9478	T11591	T11589	arg2Of	expression,of
R9479	T11591	T11590	arg1Of	expression,IRF-4
R9480	T11591	T11592	arg1Of	expression,in
R9481	T11595	T11592	arg2Of	leukemias,in
R9482	T11595	T11593	arg1Of	leukemias,human
R9483	T11595	T11594	arg1Of	leukemias,myeloid
R9484	T11596	T11583	arg2Of	was,investigated
R9485	T11596	T11584	arg1Of	was,whether
R9486	T11596	T11605	arg1Of	was,","
R9487	T11596	T11606	arg1Of	was,since
R9488	T11597	T11596	arg2Of	due,was
R9489	T11597	T11598	arg1Of	due,to
R9490	T11601	T11598	arg2Of	hypermethylation,to
R9491	T11601	T11599	arg1Of	hypermethylation,a
R9492	T11601	T11600	arg1Of	hypermethylation,differential
R9493	T11601	T11602	arg1Of	hypermethylation,of
R9494	T11604	T11602	arg2Of	promoter,of
R9495	T11604	T11603	arg1Of	promoter,the
R9496	T11609	T11607	arg1Of	re-expression,the
R9497	T11609	T11608	arg2Of	re-expression,presented
R9498	T11609	T11610	arg1Of	re-expression,due
R9499	T11609	T11613	arg1Of	re-expression,might
R9500	T11609	T11615	arg1Of	re-expression,be
R9501	T11610	T11611	arg1Of	due,to
R9502	T11612	T11610	arg2Of	AzadC-treatment,due
R9503	T11615	T11606	arg2Of	be,since
R9504	T11615	T11613	arg2Of	be,might
R9505	T11615	T11614	arg1Of	be,also
R9506	T11617	T11615	arg2Of	result,be
R9507	T11617	T11616	arg1Of	result,a
R9508	T11617	T11618	arg1Of	result,of
R9509	T11619	T11618	arg2Of	activation,of
R9510	T11619	T11620	arg1Of	activation,of
R9511	T11623	T11620	arg2Of	regulators,of
R9512	T11623	T11621	arg1Of	regulators,positive
R9513	T11623	T11622	arg1Of	regulators,transcriptional
R9514	T11623	T11624	arg1Of	regulators,of
R9515	T11625	T11624	arg2Of	IRF-4,of
R9516	T11626	T11627	arg1Of	Methylation,of
R9517	T11626	T11630	arg1Of	Methylation,is
R9518	T11626	T11640	arg1Of	Methylation,has
R9519	T11626	T11642	arg1Of	Methylation,been
R9520	T11626	T11643	arg2Of	Methylation,shown
R9521	T11629	T11627	arg2Of	sites,of
R9522	T11629	T11628	arg1Of	sites,CpG
R9523	T11630	T11639	arg1Of	is,and
R9524	T11633	T11630	arg2Of	mechanism,is
R9525	T11633	T11631	arg1Of	mechanism,a
R9526	T11633	T11632	arg1Of	mechanism,common
R9527	T11633	T11634	arg1Of	mechanism,of
R9528	T11633	T11637	arg1Of	mechanism,in
R9529	T11636	T11634	arg2Of	genes,of
R9530	T11636	T11635	arg1Of	genes,silencing
R9531	T11638	T11637	arg2Of	leukemia,in
R9532	T11643	T11639	arg2Of	shown,and
R9533	T11643	T11640	arg2Of	shown,has
R9534	T11643	T11641	arg1Of	shown,also
R9535	T11643	T11642	arg2Of	shown,been
R9536	T11643	T11644	arg1Of	shown,for
R9537	T11643	T11653	arg1Of	shown,for
R9538	T11644	T11652	arg1Of	for,and
R9539	T11646	T11645	arg1Of	IRF,another
R9540	T11646	T11647	arg1Of	IRF,","
R9541	T11647	T11644	arg2Of	",",for
R9542	T11648	T11647	arg2Of	IRF-7,","
R9543	T11648	T11649	arg1Of	IRF-7,(
R9544	T11650	T11649	arg2Of	35,(
R9545	T11651	T11649	arg3Of	),(
R9546	T11653	T11652	arg2Of	for,and
R9547	T11654	T11653	arg2Of	PU.1,for
R9548	T11654	T11655	arg1Of	PU.1,(
R9549	T11654	T11658	arg1Of	PU.1,","
R9550	T11656	T11655	arg2Of	36,(
R9551	T11657	T11655	arg3Of	),(
R9552	T11661	T11658	arg2Of	partner,","
R9553	T11661	T11659	arg1Of	partner,an
R9554	T11661	T11660	arg1Of	partner,interacting
R9555	T11661	T11662	arg1Of	partner,of
R9556	T11663	T11662	arg2Of	IRF-4,of
R9557	T11665	T11664	arg1Of	elucidate,To
R9558	T11665	T11688	arg1Of	elucidate,were
R9559	T11665	T11689	arg2Of	elucidate,sequenced
R9560	T11667	T11665	arg2Of	relevance,elucidate
R9561	T11667	T11666	arg1Of	relevance,the
R9562	T11667	T11668	arg1Of	relevance,of
R9563	T11670	T11668	arg2Of	mechanism,of
R9564	T11670	T11669	arg1Of	mechanism,this
R9565	T11670	T11671	arg1Of	mechanism,for
R9566	T11673	T11671	arg2Of	regulation,for
R9567	T11673	T11672	arg1Of	regulation,the
R9568	T11673	T11674	arg1Of	regulation,of
R9569	T11676	T11674	arg2Of	expression,of
R9570	T11676	T11675	arg1Of	expression,IRF-4
R9571	T11680	T11678	arg1Of	cells,various
R9572	T11680	T11679	arg1Of	cells,leukemic
R9573	T11680	T11681	arg1Of	cells,were
R9574	T11680	T11682	arg2Of	cells,treated
R9575	T11682	T11681	arg2Of	treated,were
R9576	T11682	T11683	arg1Of	treated,with
R9577	T11685	T11686	arg1Of	agents,and
R9578	T11686	T11683	arg2Of	and,with
R9579	T11686	T11684	arg1Of	and,demethylating
R9580	T11687	T11686	arg2Of	promoters,and
R9581	T11689	T11677	arg1Of	sequenced,","
R9582	T11689	T11681	modOf	sequenced,were
R9583	T11689	T11688	arg2Of	sequenced,were
R9584	T11689	T11690	arg1Of	sequenced,after
R9585	T11692	T11690	arg2Of	treatment,after
R9586	T11692	T11691	arg1Of	treatment,bisulfite
R9587	T11693	T11694	arg1Of	We,found
R9588	T11697	T11696	arg1Of	expression,IRF-4
R9589	T11697	T11698	arg1Of	expression,could
R9590	T11697	T11700	arg1Of	expression,be
R9591	T11697	T11701	arg2Of	expression,connected
R9592	T11701	T11694	arg2Of	connected,found
R9593	T11701	T11695	arg1Of	connected,that
R9594	T11701	T11698	arg2Of	connected,could
R9595	T11701	T11699	arg1Of	connected,indeed
R9596	T11701	T11700	arg2Of	connected,be
R9597	T11701	T11702	arg1Of	connected,to
R9598	T11705	T11702	arg2Of	status,to
R9599	T11705	T11703	arg1Of	status,the
R9600	T11705	T11704	arg1Of	status,methylation
R9601	T11705	T11706	arg1Of	status,of
R9602	T11709	T11706	arg2Of	motifs,of
R9603	T11709	T11707	arg1Of	motifs,distinct
R9604	T11709	T11708	arg1Of	motifs,CpG
R9605	T11709	T11710	arg1Of	motifs,in
R9606	T11713	T11710	arg2Of	promoter,in
R9607	T11713	T11711	arg1Of	promoter,the
R9608	T11713	T11712	arg1Of	promoter,IRF-4
R9609	T11716	T11714	arg2Of	4A,In
R9610	T11716	T11715	arg1Of	4A,Figure
R9611	T11720	T11718	arg1Of	sites,those
R9612	T11720	T11719	arg1Of	sites,CpG
R9613	T11720	T11721	arg1Of	sites,are
R9614	T11720	T11722	arg2Of	sites,shown
R9615	T11722	T11714	arg1Of	shown,In
R9616	T11722	T11717	arg1Of	shown,","
R9617	T11722	T11721	arg2Of	shown,are
R9618	T11722	T11723	arg1Of	shown,(
R9619	T11722	T11727	arg1Of	shown,","
R9620	T11725	T11723	arg2Of	line,(
R9621	T11725	T11724	arg1Of	line,bottom
R9622	T11726	T11723	arg3Of	),(
R9623	T11728	T11722	arg3Of	whose,shown
R9624	T11729	T11728	arg1Of	hypermethylation,whose
R9625	T11729	T11730	arg1Of	hypermethylation,may
R9626	T11729	T11731	arg1Of	hypermethylation,account
R9627	T11731	T11730	arg2Of	account,may
R9628	T11731	T11732	arg1Of	account,for
R9629	T11734	T11732	arg2Of	absence,for
R9630	T11734	T11733	arg1Of	absence,the
R9631	T11734	T11735	arg1Of	absence,of
R9632	T11737	T11735	arg2Of	expression,of
R9633	T11737	T11736	arg1Of	expression,IRF-4
R9634	T11737	T11738	arg1Of	expression,in
R9635	T11741	T11738	arg2Of	cells,in
R9636	T11741	T11739	arg1Of	cells,the
R9637	T11741	T11740	arg1Of	cells,respective
R9638	T11742	T11743	arg1Of	One,of
R9639	T11742	T11749	arg1Of	One,is
R9640	T11744	T11743	arg2Of	them,of
R9641	T11744	T11745	arg1Of	them,(
R9642	T11747	T11745	arg2Of	54,(
R9643	T11747	T11746	arg1Of	54,#
R9644	T11748	T11745	arg3Of	),(
R9645	T11749	T11759	arg1Of	is,","
R9646	T11749	T11760	modOf	is,indicating
R9647	T11750	T11749	arg2Of	adjacent,is
R9648	T11750	T11751	arg1Of	adjacent,to
R9649	T11755	T11751	arg2Of	element,to
R9650	T11755	T11752	arg1Of	element,an
R9651	T11755	T11753	arg2Of	element,identified
R9652	T11755	T11754	arg1Of	element,regulatory
R9653	T11755	T11756	arg1Of	element,(
R9654	T11757	T11756	arg2Of	NFκB-site,(
R9655	T11758	T11756	arg3Of	),(
R9656	T11763	T11760	arg2Of	involvement,indicating
R9657	T11763	T11761	arg1Of	involvement,a
R9658	T11763	T11762	arg1Of	involvement,possible
R9659	T11763	T11764	arg1Of	involvement,of
R9660	T11766	T11764	arg2Of	site,of
R9661	T11766	T11765	arg1Of	site,this
R9662	T11771	T11767	arg2Of	sites,At
R9663	T11771	T11768	arg1Of	sites,two
R9664	T11771	T11769	arg1Of	sites,further
R9665	T11771	T11770	arg1Of	sites,CpG
R9666	T11771	T11772	arg1Of	sites,(
R9667	T11774	T11772	arg2Of	48,(
R9668	T11774	T11773	arg1Of	48,#
R9669	T11774	T11775	arg1Of	48,","
R9670	T11776	T11775	arg2Of	45,","
R9671	T11777	T11772	arg3Of	),(
R9672	T11780	T11778	arg1Of	status,the
R9673	T11780	T11779	arg1Of	status,methylation
R9674	T11780	T11781	arg1Of	status,in
R9675	T11780	T11783	arg1Of	status,was
R9676	T11780	T11784	arg1Of	status,lower
R9677	T11782	T11781	arg2Of	IRF-4-positive,in
R9678	T11783	T11767	arg1Of	was,At
R9679	T11784	T11783	arg2Of	lower,was
R9680	T11784	T11785	arg1Of	lower,than
R9681	T11786	T11785	arg2Of	that,than
R9682	T11786	T11787	arg1Of	that,of
R9683	T11789	T11787	arg2Of	cells,of
R9684	T11789	T11788	arg1Of	cells,IRF-4-negative
R9685	T11792	T11790	arg1Of	sites,These
R9686	T11792	T11791	arg1Of	sites,CpG
R9687	T11792	T11793	arg1Of	sites,are
R9688	T11792	T11794	arg1Of	sites,located
R9689	T11792	T11807	arg1Of	sites,may
R9690	T11792	T11809	arg1Of	sites,play
R9691	T11793	T11805	arg1Of	are,and
R9692	T11794	T11793	arg2Of	located,are
R9693	T11794	T11795	arg1Of	located,in
R9694	T11797	T11796	arg1Of	NFκB,an
R9695	T11797	T11798	arg1Of	NFκB,and
R9696	T11798	T11795	arg2Of	and,in
R9697	T11801	T11798	arg2Of	element,and
R9698	T11801	T11799	arg1Of	element,an
R9699	T11801	T11800	arg1Of	element,SP1
R9700	T11801	T11802	arg1Of	element,(
R9701	T11803	T11802	arg2Of	31,(
R9702	T11804	T11802	arg3Of	),(
R9703	T11809	T11805	arg2Of	play,and
R9704	T11809	T11806	arg1Of	play,thus
R9705	T11809	T11807	arg2Of	play,may
R9706	T11809	T11808	arg1Of	play,also
R9707	T11809	T11812	arg1Of	play,in
R9708	T11811	T11809	arg2Of	role,play
R9709	T11811	T11810	arg1Of	role,a
R9710	T11813	T11812	arg2Of	regulation,in
R9711	T11813	T11814	arg1Of	regulation,of
R9712	T11816	T11814	arg2Of	expression,of
R9713	T11816	T11815	arg1Of	expression,IRF-4
R9714	T11817	T11818	arg1Of	It,has
R9715	T11817	T11819	arg1Of	It,been
R9716	T11817	T11820	arg2Of	It,shown
R9717	T11820	T11818	arg2Of	shown,has
R9718	T11820	T11819	arg2Of	shown,been
R9719	T11823	T11822	arg1Of	elements,NFκB
R9720	T11823	T11824	arg1Of	elements,play
R9721	T11824	T11820	arg3Of	play,shown
R9722	T11824	T11821	arg1Of	play,that
R9723	T11824	T11828	arg1Of	play,in
R9724	T11824	T11831	arg1Of	play,as
R9725	T11827	T11824	arg2Of	role,play
R9726	T11827	T11825	arg1Of	role,an
R9727	T11827	T11826	arg1Of	role,important
R9728	T11830	T11828	arg2Of	induction,in
R9729	T11830	T11829	arg1Of	induction,IRF-4
R9730	T11833	T11832	arg1Of	expression,IRF-4
R9731	T11833	T11834	arg1Of	expression,depends
R9732	T11834	T11831	arg2Of	depends,as
R9733	T11834	T11835	arg1Of	depends,on
R9734	T11836	T11835	arg2Of	binding,on
R9735	T11836	T11837	arg1Of	binding,of
R9736	T11836	T11841	arg1Of	binding,to
R9737	T11840	T11837	arg2Of	c-Rel,of
R9738	T11840	T11838	arg1Of	c-Rel,the
R9739	T11840	T11839	arg1Of	c-Rel,transactivator
R9740	T11843	T11841	arg2Of	elements,to
R9741	T11843	T11842	arg1Of	elements,these
R9742	T11843	T11844	arg1Of	elements,in
R9743	T11847	T11844	arg2Of	promoter,in
R9744	T11847	T11845	arg1Of	promoter,the
R9745	T11847	T11846	arg1Of	promoter,IRF-4
R9746	T11847	T11848	arg1Of	promoter,(
R9747	T11849	T11848	arg2Of	"31,37",(
R9748	T11850	T11848	arg3Of	),(
R9749	T11853	T11854	arg1Of	methylation,of
R9750	T11853	T11862	arg1Of	methylation,inhibits
R9751	T11857	T11854	arg2Of	CpG,of
R9752	T11857	T11855	arg1Of	CpG,the
R9753	T11857	T11856	arg1Of	CpG,central
R9754	T11857	T11858	arg1Of	CpG,in
R9755	T11861	T11858	arg2Of	element,in
R9756	T11861	T11859	arg1Of	element,the
R9757	T11861	T11860	arg1Of	element,NFκB
R9758	T11862	T11851	arg1Of	inhibits,Furthermore
R9759	T11862	T11852	arg1Of	inhibits,","
R9760	T11862	T11872	arg1Of	inhibits,","
R9761	T11863	T11862	arg2Of	binding,inhibits
R9762	T11863	T11864	arg1Of	binding,of
R9763	T11868	T11864	arg2Of	complexes,of
R9764	T11868	T11865	arg1Of	complexes,the
R9765	T11868	T11866	arg1Of	complexes,NFκB
R9766	T11868	T11867	arg1Of	complexes,protein
R9767	T11868	T11869	arg1Of	complexes,(
R9768	T11870	T11869	arg2Of	38,(
R9769	T11871	T11869	arg3Of	),(
R9770	T11873	T11862	arg3Of	promoting,inhibits
R9771	T11875	T11873	arg2Of	significance,promoting
R9772	T11875	T11874	arg1Of	significance,the
R9773	T11875	T11876	arg1Of	significance,of
R9774	T11880	T11876	arg2Of	differences,of
R9775	T11880	T11877	arg1Of	differences,the
R9776	T11880	T11878	arg2Of	differences,observed
R9777	T11880	T11879	arg1Of	differences,methylation
R9778	T11880	T11881	arg1Of	differences,in
R9779	T11882	T11883	arg1Of	IRF-4-positive,and
R9780	T11884	T11883	arg2Of	-negative,and
R9781	T11885	T11881	arg2Of	cells,in
R9782	T11885	T11882	arg1Of	cells,IRF-4-positive
R9783	T11885	T11884	arg1Of	cells,-negative
R9784	T11888	T11887	arg1Of	vitro,in
R9785	T11889	T11890	arg1Of	methylation,and
R9786	T11891	T11890	arg2Of	reporter,and
R9787	T11893	T11886	arg2Of	assays,Via
R9788	T11893	T11888	arg1Of	assays,vitro
R9789	T11893	T11889	arg1Of	assays,methylation
R9790	T11893	T11891	arg1Of	assays,reporter
R9791	T11893	T11892	arg1Of	assays,gene
R9792	T11894	T11895	arg1Of	we,could
R9793	T11894	T11897	arg1Of	we,appoint
R9794	T11897	T11886	modOf	appoint,Via
R9795	T11897	T11895	arg2Of	appoint,could
R9796	T11897	T11896	arg1Of	appoint,clearly
R9797	T11897	T11904	arg1Of	appoint,to
R9798	T11899	T11897	arg2Of	silencing,appoint
R9799	T11899	T11898	arg1Of	silencing,the
R9800	T11899	T11900	arg1Of	silencing,of
R9801	T11903	T11900	arg2Of	promoter,of
R9802	T11903	T11901	arg1Of	promoter,the
R9803	T11903	T11902	arg1Of	promoter,IRF-4
R9804	T11907	T11904	arg2Of	effect,to
R9805	T11907	T11905	arg1Of	effect,a
R9806	T11907	T11906	arg1Of	effect,methylation
R9807	T11907	T11908	arg1Of	effect,","
R9808	T11907	T11909	arg1Of	effect,which
R9809	T11907	T11910	arg1Of	effect,may
R9810	T11907	T11912	arg1Of	effect,be
R9811	T11912	T11910	arg2Of	be,may
R9812	T11912	T11911	arg1Of	be,thus
R9813	T11912	T11919	arg1Of	be,vivo
R9814	T11914	T11912	arg2Of	mechanism,be
R9815	T11914	T11913	arg1Of	mechanism,the
R9816	T11914	T11915	arg1Of	mechanism,of
R9817	T11917	T11915	arg2Of	deregulation,of
R9818	T11917	T11916	arg1Of	deregulation,IRF-4
R9819	T11919	T11918	arg1Of	vivo,in
R9820	T11922	T11920	arg1Of	cause,One
R9821	T11922	T11921	arg1Of	cause,possible
R9822	T11922	T11923	arg1Of	cause,for
R9823	T11922	T11929	arg1Of	cause,is
R9824	T11926	T11923	arg2Of	methylation,for
R9825	T11926	T11924	arg1Of	methylation,the
R9826	T11926	T11925	arg1Of	methylation,aberrant
R9827	T11926	T11927	arg1Of	methylation,in
R9828	T11928	T11927	arg2Of	tumorigenesis,in
R9829	T11932	T11929	arg2Of	level,is
R9830	T11932	T11930	arg1Of	level,an
R9831	T11932	T11931	arg2Of	level,increased
R9832	T11932	T11933	arg1Of	level,of
R9833	T11932	T11935	arg1Of	level,during
R9834	T11934	T11933	arg2Of	DNMTs,of
R9835	T11938	T11935	arg2Of	process,during
R9836	T11938	T11936	arg1Of	process,the
R9837	T11938	T11937	arg1Of	process,pathogenetic
R9838	T11940	T11941	arg1Of	colon,","
R9839	T11941	T11943	arg1Of	",",and
R9840	T11942	T11941	arg2Of	lung,","
R9841	T11943	T11939	arg2Of	and,In
R9842	T11945	T11943	arg2Of	malignancies,and
R9843	T11945	T11944	arg1Of	malignancies,hematologic
R9844	T11947	T11948	arg1Of	overexpression,of
R9845	T11947	T11955	arg1Of	overexpression,has
R9846	T11947	T11956	arg1Of	overexpression,been
R9847	T11947	T11957	arg2Of	overexpression,detected
R9848	T11949	T11948	arg2Of	DNMT1,of
R9849	T11949	T11950	arg1Of	DNMT1,","
R9850	T11953	T11950	arg2Of	DNMT,","
R9851	T11953	T11951	arg1Of	DNMT,a
R9852	T11953	T11952	arg1Of	DNMT,maintenance
R9853	T11957	T11939	arg1Of	detected,In
R9854	T11957	T11946	arg1Of	detected,","
R9855	T11957	T11954	arg1Of	detected,","
R9856	T11957	T11955	arg2Of	detected,has
R9857	T11957	T11956	arg2Of	detected,been
R9858	T11957	T11958	arg1Of	detected,(
R9859	T11959	T11958	arg2Of	39–41,(
R9860	T11960	T11958	arg3Of	),(
R9861	T11963	T11964	arg1Of	it,has
R9862	T11963	T11965	arg1Of	it,been
R9863	T11963	T11966	arg2Of	it,shown
R9864	T11966	T11961	arg1Of	shown,Furthermore
R9865	T11966	T11962	arg1Of	shown,","
R9866	T11966	T11964	arg2Of	shown,has
R9867	T11966	T11965	arg2Of	shown,been
R9868	T11969	T11968	arg1Of	cells,CML
R9869	T11969	T11970	arg1Of	cells,in
R9870	T11969	T11974	arg1Of	cells,exhibited
R9871	T11973	T11970	arg2Of	phase,in
R9872	T11973	T11971	arg1Of	phase,the
R9873	T11973	T11972	arg1Of	phase,acute
R9874	T11974	T11966	arg3Of	exhibited,shown
R9875	T11974	T11967	arg1Of	exhibited,that
R9876	T11974	T11982	arg1Of	exhibited,","
R9877	T11974	T11983	arg1Of	exhibited,while
R9878	T11976	T11974	arg2Of	levels,exhibited
R9879	T11976	T11975	arg1Of	levels,elevated
R9880	T11976	T11977	arg1Of	levels,of
R9881	T11981	T11977	arg2Of	DNMTs,of
R9882	T11981	T11978	arg1Of	DNMTs,the
R9883	T11981	T11979	arg1Of	DNMTs,three
R9884	T11981	T11980	arg2Of	DNMTs,known
R9885	T11985	T11984	arg1Of	cells,CML
R9886	T11985	T11986	arg1Of	cells,in
R9887	T11985	T11989	arg1Of	cells,expressed
R9888	T11988	T11986	arg2Of	phase,in
R9889	T11988	T11987	arg1Of	phase,chronic
R9890	T11989	T11983	arg2Of	expressed,while
R9891	T11989	T11994	arg1Of	expressed,if
R9892	T11991	T11989	arg2Of	levels,expressed
R9893	T11991	T11990	arg1Of	levels,normal
R9894	T11991	T11992	arg1Of	levels,of
R9895	T11993	T11992	arg2Of	DNMTs,of
R9896	T11995	T11994	arg2Of	compared,if
R9897	T11995	T11996	arg1Of	compared,with
R9898	T12000	T11996	arg2Of	cells,with
R9899	T12000	T11997	arg1Of	cells,normal
R9900	T12000	T11998	arg1Of	cells,bone
R9901	T12000	T11999	arg1Of	cells,marrow
R9902	T12000	T12001	arg1Of	cells,(
R9903	T12002	T12001	arg2Of	25,(
R9904	T12003	T12001	arg3Of	),(
R9905	T12008	T12006	arg1Of	correlation,a
R9906	T12008	T12007	arg1Of	correlation,positive
R9907	T12008	T12009	arg1Of	correlation,between
R9908	T12008	T12017	arg1Of	correlation,has
R9909	T12008	T12018	arg1Of	correlation,been
R9910	T12008	T12019	arg2Of	correlation,detected
R9911	T12012	T12010	arg1Of	levels,DNMT1
R9912	T12012	T12011	arg1Of	levels,expression
R9913	T12012	T12013	arg1Of	levels,and
R9914	T12013	T12009	arg2Of	and,between
R9915	T12014	T12013	arg2Of	hypermethylation,and
R9916	T12014	T12015	arg1Of	hypermethylation,of
R9917	T12016	T12015	arg2Of	p15INK4b,of
R9918	T12019	T12004	arg1Of	detected,Interestingly
R9919	T12019	T12005	arg1Of	detected,","
R9920	T12019	T12017	arg2Of	detected,has
R9921	T12019	T12018	arg2Of	detected,been
R9922	T12019	T12020	arg1Of	detected,in
R9923	T12021	T12020	arg2Of	AML,in
R9924	T12021	T12022	arg1Of	AML,(
R9925	T12023	T12022	arg2Of	25,(
R9926	T12024	T12022	arg3Of	),(
R9927	T12027	T12025	arg2Of	work,In
R9928	T12027	T12026	arg1Of	work,this
R9929	T12029	T12030	arg1Of	we,did
R9930	T12029	T12032	arg1Of	we,detect
R9931	T12032	T12025	arg1Of	detect,In
R9932	T12032	T12028	arg1Of	detect,","
R9933	T12032	T12030	arg2Of	detect,did
R9934	T12032	T12031	arg1Of	detect,not
R9935	T12032	T12042	arg1Of	detect,","
R9936	T12032	T12043	modOf	detect,making
R9937	T12036	T12032	arg2Of	differences,detect
R9938	T12036	T12033	arg1Of	differences,significant
R9939	T12036	T12034	arg1Of	differences,mRNA
R9940	T12036	T12035	arg1Of	differences,expression
R9941	T12036	T12037	arg1Of	differences,of
R9942	T12039	T12040	arg1Of	DNMT,or
R9943	T12040	T12037	arg2Of	or,of
R9944	T12040	T12038	arg2Of	or,selected
R9945	T12041	T12040	arg2Of	MBP,or
R9946	T12044	T12043	arg2Of	it,making
R9947	T12047	T12043	arg3Of	cause,making
R9948	T12047	T12045	arg1Of	cause,an
R9949	T12047	T12046	arg1Of	cause,unlikely
R9950	T12047	T12048	arg1Of	cause,for
R9951	T12051	T12050	arg2Of	methylation,observed
R9952	T12051	T12052	arg1Of	methylation,and
R9953	T12052	T12048	arg2Of	and,for
R9954	T12052	T12049	arg1Of	and,the
R9955	T12052	T12057	arg1Of	and,in
R9956	T12056	T12052	arg2Of	differences,and
R9957	T12056	T12053	arg1Of	differences,thus
R9958	T12056	T12054	arg1Of	differences,IRF-4
R9959	T12056	T12055	arg1Of	differences,expression
R9960	T12059	T12057	arg2Of	cells,in
R9961	T12059	T12058	arg1Of	cells,leukemia
R9962	T12061	T12060	arg1Of	finding,The
R9963	T12061	T12070	arg1Of	finding,might
R9964	T12061	T12071	arg1Of	finding,represent
R9965	T12064	T12063	arg1Of	expression,IRF-4
R9966	T12064	T12065	arg1Of	expression,is
R9967	T12064	T12066	arg2Of	expression,silenced
R9968	T12066	T12061	arg2Of	silenced,finding
R9969	T12066	T12062	arg1Of	silenced,that
R9970	T12066	T12065	arg2Of	silenced,is
R9971	T12069	T12066	arg1Of	hypermethylation,silenced
R9972	T12069	T12067	arg2Of	hypermethylation,by
R9973	T12069	T12068	arg1Of	hypermethylation,promoter
R9974	T12071	T12070	arg2Of	represent,might
R9975	T12073	T12071	arg2Of	mechanism,represent
R9976	T12073	T12072	arg1Of	mechanism,a
R9977	T12073	T12074	arg1Of	mechanism,that
R9978	T12073	T12075	arg1Of	mechanism,accounts
R9979	T12075	T12076	arg1Of	accounts,for
R9980	T12079	T12078	arg1Of	observed,previously
R9981	T12080	T12076	arg2Of	loss,for
R9982	T12080	T12077	arg1Of	loss,the
R9983	T12080	T12079	arg1Of	loss,observed
R9984	T12080	T12081	arg1Of	loss,of
R9985	T12083	T12081	arg2Of	expression,of
R9986	T12083	T12082	arg1Of	expression,IRF-4
R9987	T12083	T12084	arg1Of	expression,in
R9988	T12085	T12084	arg2Of	CML,in
R9989	T12090	T12088	arg1Of	trials,several
R9990	T12090	T12089	arg1Of	trials,clinical
R9991	T12090	T12091	arg1Of	trials,with
R9992	T12090	T12099	arg1Of	trials,demonstrated
R9993	T12093	T12092	arg1Of	patients,leukemia
R9994	T12093	T12094	arg1Of	patients,and
R9995	T12094	T12091	arg2Of	and,with
R9996	T12095	T12094	arg2Of	patients,and
R9997	T12095	T12096	arg1Of	patients,with
R9998	T12098	T12096	arg2Of	syndromes,with
R9999	T12098	T12097	arg1Of	syndromes,myelodysplastic

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