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PMC:1310901 / 156-1797 JSONTXT 17 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T150 0-8 IN denotes Although
T151 9-12 DT denotes the
T152 13-20 NN denotes bcr-abl
T153 21-34 NN denotes translocation
T154 35-38 VB denotes has
T155 39-43 VB denotes been
T156 44-49 VB denotes shown
T157 50-52 TO denotes to
T158 53-55 VB denotes be
T159 56-59 DT denotes the
T160 60-69 JJ denotes causative
T161 70-77 JJ denotes genetic
T162 78-88 NN denotes aberration
T163 89-91 IN denotes in
T164 92-99 JJ denotes chronic
T165 100-107 JJ denotes myeloid
T166 108-116 NN denotes leukemia
T167 117-118 -LRB- denotes (
T168 118-121 NN denotes CML
T169 121-122 -RRB- denotes )
T170 122-123 -COMMA- denotes ,
T171 124-129 EX denotes there
T172 130-132 VB denotes is
T173 133-141 VB denotes mounting
T174 142-150 NN denotes evidence
T175 151-155 IN denotes that
T176 156-159 DT denotes the
T177 160-172 NN denotes deregulation
T178 173-175 IN denotes of
T179 176-181 JJ denotes other
T180 182-187 NN denotes genes
T181 187-188 -COMMA- denotes ,
T182 189-193 JJ denotes such
T183 194-196 IN denotes as
T184 197-200 DT denotes the
T185 201-214 NN denotes transcription
T186 215-221 NN denotes factor
T187 222-232 NN denotes interferon
T188 233-243 JJ denotes regulatory
T189 244-250 NN denotes factor
T190 251-252 CD denotes 4
T191 253-254 -LRB- denotes (
T192 254-259 NN denotes IRF-4
T193 259-260 -RRB- denotes )
T194 260-261 -COMMA- denotes ,
T195 262-264 VB denotes is
T196 265-269 RB denotes also
T197 270-280 VB denotes implicated
T198 281-283 IN denotes in
T199 284-287 DT denotes the
T200 288-300 NN denotes pathogenesis
T201 301-303 IN denotes of
T202 304-307 NN denotes CML
T203 309-317 NN denotes Promoter
T204 318-329 NN denotes methylation
T205 330-332 IN denotes of
T206 333-336 NN denotes CpG
T207 337-343 NN denotes target
T208 344-349 NN denotes sites
T209 350-352 CC denotes or
T210 353-359 JJ denotes direct
T211 360-380 NN denotes deletions/insertions
T212 381-383 IN denotes of
T213 384-389 NN denotes genes
T214 390-393 VB denotes are
T215 394-404 NN denotes mechanisms
T216 405-407 IN denotes of
T217 408-409 DT denotes a
T218 410-420 JJ denotes reversible
T219 421-423 CC denotes or
T220 424-433 JJ denotes permanent
T221 434-443 NN denotes silencing
T222 444-446 IN denotes of
T223 447-451 NN denotes gene
T224 452-462 NN denotes expression
T225 462-463 -COMMA- denotes ,
T226 464-476 RB denotes respectively
T227 478-487 RB denotes Therefore
T228 487-488 -COMMA- denotes ,
T229 489-491 PRP denotes we
T230 492-504 VB denotes investigated
T231 505-512 IN denotes whether
T232 513-518 NN denotes IRF-4
T233 519-527 NN denotes promoter
T234 528-539 NN denotes methylation
T235 540-542 CC denotes or
T236 543-551 NN denotes mutation
T237 552-555 MD denotes may
T238 556-558 VB denotes be
T239 559-567 VB denotes involved
T240 568-570 IN denotes in
T241 571-574 DT denotes the
T242 575-585 NN denotes regulation
T243 586-588 IN denotes of
T244 589-594 NN denotes IRF-4
T245 595-605 NN denotes expression
T246 606-608 IN denotes in
T247 609-617 NN denotes leukemia
T248 618-623 NN denotes cells
T249 625-632 IN denotes Whereas
T250 633-641 NN denotes promoter
T251 642-651 NN denotes mutations
T252 652-654 CC denotes or
T253 655-665 JJ denotes structural
T254 666-680 NN denotes rearrangements
T255 681-686 MD denotes could
T256 687-689 VB denotes be
T257 690-698 VB denotes excluded
T258 699-701 IN denotes as
T259 702-703 DT denotes a
T260 704-709 NN denotes cause
T261 710-712 IN denotes of
T262 713-720 VB denotes altered
T263 721-726 NN denotes IRF-4
T264 727-737 NN denotes expression
T265 738-740 IN denotes in
T266 741-754 JJ denotes hematopoietic
T267 755-760 NN denotes cells
T268 760-761 -COMMA- denotes ,
T269 762-765 DT denotes the
T270 766-771 NN denotes IRF-4
T271 772-780 NN denotes promoter
T272 781-792 NN denotes methylation
T273 793-799 NN denotes status
T274 800-803 VB denotes was
T275 804-809 VB denotes found
T276 810-812 TO denotes to
T277 813-826 RB denotes significantly
T278 827-836 VB denotes influence
T279 837-842 NN denotes IRF-4
T280 843-856 NN denotes transcription
T281 858-863 RB denotes First
T282 863-864 -COMMA- denotes ,
T283 865-874 NN denotes treatment
T284 875-877 IN denotes of
T285 878-892 JJ denotes IRF-4-negative
T286 893-901 JJ denotes lymphoid
T287 901-902 -COMMA- denotes ,
T288 903-910 JJ denotes myeloid
T289 911-914 CC denotes and
T290 915-924 JJ denotes monocytic
T291 925-929 NN denotes cell
T292 930-935 NN denotes lines
T293 936-940 IN denotes with
T294 941-944 DT denotes the
T295 945-966 NN denotes methylation-inhibitor
T296 967-988 NN denotes 5-aza-2-deoxycytidine
T297 989-997 VB denotes resulted
T298 998-1000 IN denotes in
T299 1001-1002 DT denotes a
T300 1003-1008 NN denotes time-
T301 1009-1012 CC denotes and
T302 1013-1036 JJ denotes concentration-dependent
T303 1037-1045 NN denotes increase
T304 1046-1048 IN denotes of
T305 1049-1054 NN denotes IRF-4
T306 1055-1059 NN denotes mRNA
T307 1060-1063 CC denotes and
T308 1064-1071 NN denotes protein
T309 1072-1078 NN denotes levels
T310 1080-1086 RB denotes Second
T311 1086-1087 -COMMA- denotes ,
T312 1088-1093 VB denotes using
T313 1094-1095 DT denotes a
T314 1096-1117 NN denotes restriction-PCR-assay
T315 1118-1121 CC denotes and
T316 1122-1142 NN denotes bisulfite-sequencing
T317 1143-1145 PRP denotes we
T318 1146-1156 VB denotes identified
T319 1157-1169 RB denotes specifically
T320 1170-1180 VB denotes methylated
T321 1181-1184 NN denotes CpG
T322 1185-1190 NN denotes sites
T323 1191-1193 IN denotes in
T324 1194-1208 JJ denotes IRF-4-negative
T325 1209-1212 CC denotes but
T326 1213-1216 RB denotes not
T327 1217-1219 IN denotes in
T328 1220-1234 JJ denotes IRF-4-positive
T329 1235-1240 NN denotes cells
T330 1242-1247 RB denotes Third
T331 1247-1248 -COMMA- denotes ,
T332 1249-1251 PRP denotes we
T333 1252-1259 RB denotes clearly
T334 1260-1270 VB denotes determined
T335 1271-1279 NN denotes promoter
T336 1280-1291 NN denotes methylation
T337 1292-1294 IN denotes as
T338 1295-1296 DT denotes a
T339 1297-1306 NN denotes mechanism
T340 1307-1310 IN denotes for
T341 1311-1316 NN denotes IRF-4
T342 1317-1332 NN denotes down-regulation
T343 1333-1336 IN denotes via
T344 1337-1345 NN denotes reporter
T345 1346-1350 NN denotes gene
T346 1351-1357 NN denotes assays
T347 1357-1358 -COMMA- denotes ,
T348 1359-1362 CC denotes but
T349 1363-1366 VB denotes did
T350 1367-1370 RB denotes not
T351 1371-1377 VB denotes detect
T352 1378-1380 DT denotes an
T353 1381-1392 NN denotes association
T354 1393-1395 IN denotes of
T355 1396-1409 JJ denotes methylational
T356 1410-1416 NN denotes status
T357 1417-1420 CC denotes and
T358 1421-1425 NN denotes mRNA
T359 1426-1436 NN denotes expression
T360 1437-1439 IN denotes of
T361 1440-1443 NN denotes DNA
T362 1444-1462 NN denotes methyltransferases
T363 1463-1465 CC denotes or
T364 1466-1484 JJ denotes methyl-CpG-binding
T365 1485-1493 NN denotes proteins
T366 1495-1503 RB denotes Together
T367 1503-1504 -COMMA- denotes ,
T368 1505-1510 DT denotes these
T369 1511-1515 NN denotes data
T370 1516-1523 VB denotes suggest
T371 1524-1527 NN denotes CpG
T372 1528-1541 JJ denotes site-specific
T373 1542-1547 NN denotes IRF-4
T374 1548-1556 NN denotes promoter
T375 1557-1568 NN denotes methylation
T376 1569-1571 IN denotes as
T377 1572-1573 DT denotes a
T378 1574-1582 JJ denotes putative
T379 1583-1592 NN denotes mechanism
T380 1593-1595 IN denotes of
T381 1596-1610 VB denotes down-regulated
T382 1611-1616 NN denotes IRF-4
T383 1617-1627 NN denotes expression
T384 1628-1630 IN denotes in
T385 1631-1639 NN denotes leukemia
R100 T189 T186 arg1Of factor,factor
R101 T189 T187 arg1Of factor,interferon
R102 T189 T188 arg1Of factor,regulatory
R103 T189 T190 arg1Of factor,4
R104 T189 T191 arg1Of factor,(
R105 T192 T191 arg2Of IRF-4,(
R106 T193 T191 arg3Of ),(
R107 T197 T174 arg2Of implicated,evidence
R108 T197 T175 arg1Of implicated,that
R109 T197 T194 arg1Of implicated,","
R110 T197 T195 arg2Of implicated,is
R111 T197 T196 arg1Of implicated,also
R112 T197 T198 arg1Of implicated,in
R113 T200 T198 arg2Of pathogenesis,in
R114 T200 T199 arg1Of pathogenesis,the
R115 T200 T201 arg1Of pathogenesis,of
R116 T202 T201 arg2Of CML,of
R117 T204 T203 arg1Of methylation,Promoter
R118 T204 T205 arg1Of methylation,of
R119 T204 T214 arg1Of methylation,are
R120 T208 T206 arg1Of sites,CpG
R121 T208 T207 arg1Of sites,target
R122 T208 T209 arg1Of sites,or
R123 T209 T205 arg2Of or,of
R124 T211 T209 arg2Of deletions/insertions,or
R125 T211 T210 arg1Of deletions/insertions,direct
R126 T211 T212 arg1Of deletions/insertions,of
R127 T213 T212 arg2Of genes,of
R128 T214 T225 arg1Of are,","
R129 T214 T226 arg1Of are,respectively
R130 T215 T214 arg2Of mechanisms,are
R131 T215 T216 arg1Of mechanisms,of
R132 T218 T219 arg1Of reversible,or
R133 T220 T219 arg2Of permanent,or
R134 T221 T216 arg2Of silencing,of
R135 T221 T217 arg1Of silencing,a
R136 T221 T218 arg1Of silencing,reversible
R137 T221 T220 arg1Of silencing,permanent
R138 T221 T222 arg1Of silencing,of
R139 T224 T222 arg2Of expression,of
R140 T224 T223 arg1Of expression,gene
R141 T229 T230 arg1Of we,investigated
R142 T230 T227 arg1Of investigated,Therefore
R143 T230 T228 arg1Of investigated,","
R144 T234 T232 arg1Of methylation,IRF-4
R145 T234 T233 arg1Of methylation,promoter
R146 T234 T235 arg1Of methylation,or
R147 T235 T237 arg1Of or,may
R148 T235 T238 arg1Of or,be
R149 T235 T239 arg2Of or,involved
R150 T236 T235 arg2Of mutation,or
R151 T239 T230 arg2Of involved,investigated
R152 T239 T231 arg1Of involved,whether
R153 T239 T237 arg2Of involved,may
R154 T239 T238 arg2Of involved,be
R155 T239 T240 arg1Of involved,in
R156 T242 T240 arg2Of regulation,in
R157 T242 T241 arg1Of regulation,the
R158 T242 T243 arg1Of regulation,of
R159 T245 T243 arg2Of expression,of
R160 T245 T244 arg1Of expression,IRF-4
R161 T245 T246 arg1Of expression,in
R162 T248 T246 arg2Of cells,in
R163 T248 T247 arg1Of cells,leukemia
R164 T251 T250 arg1Of mutations,promoter
R165 T251 T252 arg1Of mutations,or
R166 T252 T255 arg1Of or,could
R167 T252 T256 arg1Of or,be
R168 T252 T257 arg2Of or,excluded
R169 T254 T252 arg2Of rearrangements,or
R170 T254 T253 arg1Of rearrangements,structural
R171 T257 T249 arg2Of excluded,Whereas
R172 T257 T255 arg2Of excluded,could
R173 T257 T256 arg2Of excluded,be
R174 T257 T258 arg1Of excluded,as
R175 T260 T258 arg2Of cause,as
R176 T260 T259 arg1Of cause,a
R177 T260 T261 arg1Of cause,of
R178 T264 T261 arg2Of expression,of
R179 T264 T262 arg2Of expression,altered
R180 T264 T263 arg1Of expression,IRF-4
R181 T264 T265 arg1Of expression,in
R182 T267 T265 arg2Of cells,in
R183 T267 T266 arg1Of cells,hematopoietic
R184 T273 T269 arg1Of status,the
R185 T273 T270 arg1Of status,IRF-4
R186 T273 T271 arg1Of status,promoter
R187 T273 T272 arg1Of status,methylation
R188 T273 T274 arg1Of status,was
R189 T273 T275 arg2Of status,found
R190 T273 T278 arg1Of status,influence
R191 T275 T249 arg1Of found,Whereas
R192 T275 T268 arg1Of found,","
R193 T275 T274 arg2Of found,was
R194 T278 T275 arg3Of influence,found
R195 T278 T276 arg1Of influence,to
R196 T278 T277 arg1Of influence,significantly
R197 T280 T278 arg2Of transcription,influence
R198 T280 T279 arg1Of transcription,IRF-4
R199 T283 T284 arg1Of treatment,of
R200 T283 T297 arg1Of treatment,resulted
R201 T286 T287 arg1Of lymphoid,","
R202 T287 T289 arg1Of ",",and
R203 T288 T287 arg2Of myeloid,","
R204 T290 T289 arg2Of monocytic,and
R205 T292 T284 arg2Of lines,of
R206 T292 T285 arg1Of lines,IRF-4-negative
R207 T292 T286 arg1Of lines,lymphoid
R208 T292 T288 arg1Of lines,myeloid
R209 T292 T290 arg1Of lines,monocytic
R210 T292 T291 arg1Of lines,cell
R211 T292 T293 arg1Of lines,with
R212 T296 T293 arg2Of 5-aza-2-deoxycytidine,with
R213 T296 T294 arg1Of 5-aza-2-deoxycytidine,the
R214 T296 T295 arg1Of 5-aza-2-deoxycytidine,methylation-inhibitor
R215 T297 T281 arg1Of resulted,First
R216 T297 T282 arg1Of resulted,","
R217 T297 T298 arg1Of resulted,in
R218 T300 T301 arg1Of time-,and
R219 T302 T301 arg2Of concentration-dependent,and
R220 T303 T298 arg2Of increase,in
R221 T303 T299 arg1Of increase,a
R222 T303 T300 arg1Of increase,time-
R223 T303 T302 arg1Of increase,concentration-dependent
R224 T303 T304 arg1Of increase,of
R225 T306 T307 arg1Of mRNA,and
R226 T308 T307 arg2Of protein,and
R227 T309 T304 arg2Of levels,of
R228 T309 T305 arg1Of levels,IRF-4
R229 T309 T306 arg1Of levels,mRNA
R230 T309 T308 arg1Of levels,protein
R231 T314 T315 arg1Of restriction-PCR-assay,and
R232 T315 T312 arg2Of and,using
R233 T315 T313 arg1Of and,a
R234 T316 T315 arg2Of bisulfite-sequencing,and
R235 T317 T312 arg1Of we,using
R236 T317 T318 arg1Of we,identified
R237 T318 T310 arg1Of identified,Second
R238 T318 T311 arg1Of identified,","
R239 T318 T312 modOf identified,using
R240 T318 T323 arg1Of identified,in
R241 T318 T327 arg1Of identified,in
R242 T320 T319 arg1Of methylated,specifically
R243 T322 T318 arg2Of sites,identified
R244 T322 T320 arg1Of sites,methylated
R245 T322 T321 arg1Of sites,CpG
R246 T323 T325 arg1Of in,but
R247 T324 T323 arg2Of IRF-4-negative,in
R248 T327 T325 arg2Of in,but
R249 T327 T326 arg1Of in,not
R250 T329 T327 arg2Of cells,in
R251 T329 T328 arg1Of cells,IRF-4-positive
R252 T332 T334 arg1Of we,determined
R253 T332 T349 arg1Of we,did
R254 T332 T351 arg1Of we,detect
R255 T334 T337 arg1Of determined,as
R256 T334 T348 arg1Of determined,but
R257 T336 T334 arg2Of methylation,determined
R258 T336 T335 arg1Of methylation,promoter
R259 T339 T337 arg2Of mechanism,as
R260 T339 T338 arg1Of mechanism,a
R261 T339 T340 arg1Of mechanism,for
R262 T339 T343 arg1Of mechanism,via
R263 T342 T340 arg2Of down-regulation,for
R264 T342 T341 arg1Of down-regulation,IRF-4
R265 T346 T343 arg2Of assays,via
R266 T346 T344 arg1Of assays,reporter
R267 T346 T345 arg1Of assays,gene
R268 T348 T330 arg1Of but,Third
R269 T348 T331 arg1Of but,","
R270 T348 T333 arg1Of but,clearly
R271 T348 T347 arg1Of but,","
R272 T351 T348 arg2Of detect,but
R273 T351 T349 arg2Of detect,did
R274 T351 T350 arg1Of detect,not
R275 T353 T351 arg2Of association,detect
R276 T353 T352 arg1Of association,an
R277 T353 T354 arg1Of association,of
R278 T356 T357 arg1Of status,and
R279 T358 T357 arg2Of mRNA,and
R280 T359 T354 arg2Of expression,of
R281 T359 T355 arg1Of expression,methylational
R282 T359 T356 arg1Of expression,status
R283 T359 T358 arg1Of expression,mRNA
R284 T359 T360 arg1Of expression,of
R285 T362 T361 arg1Of methyltransferases,DNA
R286 T362 T363 arg1Of methyltransferases,or
R287 T363 T360 arg2Of or,of
R288 T365 T363 arg2Of proteins,or
R289 T365 T364 arg1Of proteins,methyl-CpG-binding
R290 T369 T368 arg1Of data,these
R291 T369 T370 arg1Of data,suggest
R292 T370 T366 arg1Of suggest,Together
R293 T370 T367 arg1Of suggest,","
R294 T370 T376 arg1Of suggest,as
R295 T375 T370 arg2Of methylation,suggest
R296 T375 T371 arg1Of methylation,CpG
R297 T375 T372 arg1Of methylation,site-specific
R298 T375 T373 arg1Of methylation,IRF-4
R299 T375 T374 arg1Of methylation,promoter
R300 T379 T376 arg2Of mechanism,as
R301 T379 T377 arg1Of mechanism,a
R302 T379 T378 arg1Of mechanism,putative
R303 T379 T380 arg1Of mechanism,of
R304 T379 T384 arg1Of mechanism,in
R305 T383 T380 arg2Of expression,of
R306 T383 T381 arg2Of expression,down-regulated
R307 T383 T382 arg1Of expression,IRF-4
R308 T385 T384 arg2Of leukemia,in
R61 T153 T151 arg1Of translocation,the
R62 T153 T152 arg1Of translocation,bcr-abl
R63 T153 T154 arg1Of translocation,has
R64 T153 T155 arg1Of translocation,been
R65 T153 T156 arg2Of translocation,shown
R66 T153 T158 arg1Of translocation,be
R67 T156 T150 arg2Of shown,Although
R68 T156 T154 arg2Of shown,has
R69 T156 T155 arg2Of shown,been
R70 T158 T156 arg3Of be,shown
R71 T158 T157 arg1Of be,to
R72 T158 T163 arg1Of be,in
R73 T162 T158 arg2Of aberration,be
R74 T162 T159 arg1Of aberration,the
R75 T162 T160 arg1Of aberration,causative
R76 T162 T161 arg1Of aberration,genetic
R77 T166 T163 arg2Of leukemia,in
R78 T166 T164 arg1Of leukemia,chronic
R79 T166 T165 arg1Of leukemia,myeloid
R80 T166 T167 arg1Of leukemia,(
R81 T168 T167 arg2Of CML,(
R82 T169 T167 arg3Of ),(
R83 T171 T172 arg1Of there,is
R84 T172 T150 arg1Of is,Although
R85 T172 T170 arg1Of is,","
R86 T174 T172 arg2Of evidence,is
R87 T174 T173 arg1Of evidence,mounting
R88 T177 T176 arg1Of deregulation,the
R89 T177 T178 arg1Of deregulation,of
R90 T177 T195 arg1Of deregulation,is
R91 T177 T197 arg2Of deregulation,implicated
R92 T180 T178 arg2Of genes,of
R93 T180 T179 arg1Of genes,other
R94 T180 T181 arg1Of genes,","
R95 T180 T183 arg1Of genes,as
R96 T183 T182 arg1Of as,such
R97 T189 T183 arg2Of factor,as
R98 T189 T184 arg1Of factor,the
R99 T189 T185 arg1Of factor,transcription