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PMC:1310901 / 13049-21662 JSONTXT 20 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T6221 9-16 NN denotes Absence
T6222 17-19 IN denotes of
T6223 20-25 NN denotes IRF-4
T6224 26-36 NN denotes expression
T6225 37-39 IN denotes in
T6226 40-48 NN denotes leukemia
T6227 49-54 NN denotes cells
T6228 55-57 VB denotes is
T6229 58-61 RB denotes not
T6230 62-65 JJ denotes due
T6231 66-68 TO denotes to
T6232 69-77 NN denotes promoter
T6233 78-89 NN denotes alterations
T6234 90-92 PRP denotes We
T6235 93-97 VB denotes have
T6236 98-108 RB denotes previously
T6237 109-121 VB denotes demonstrated
T6238 122-123 DT denotes a
T6239 124-128 NN denotes lack
T6240 129-131 IN denotes of
T6241 132-137 NN denotes IRF-4
T6242 138-148 NN denotes expression
T6243 149-151 IN denotes in
T6244 152-160 NN denotes leukemia
T6245 161-169 NN denotes patients
T6246 170-173 CC denotes and
T6247 174-186 RB denotes specifically
T6248 187-189 IN denotes in
T6249 190-193 NN denotes CML
T6250 194-201 NN denotes T-cells
T6251 202-203 -LRB- denotes (
T6252 203-204 CD denotes 3
T6253 204-205 -RRB- denotes )
T6254 207-211 RB denotes Here
T6255 211-212 -COMMA- denotes ,
T6256 213-215 PRP denotes we
T6257 216-227 VB denotes demonstrate
T6258 228-231 DT denotes the
T6259 232-239 NN denotes absence
T6260 240-242 IN denotes of
T6261 243-248 NN denotes IRF-4
T6262 249-259 NN denotes expression
T6263 260-262 IN denotes in
T6264 263-270 JJ denotes various
T6265 271-284 JJ denotes hematopoietic
T6266 285-289 NN denotes cell
T6267 290-295 NN denotes lines
T6268 295-296 -COMMA- denotes ,
T6269 297-301 JJ denotes such
T6270 302-304 IN denotes as
T6271 305-311 NN denotes Jurkat
T6272 311-312 -COMMA- denotes ,
T6273 313-314 DT denotes a
T6274 315-321 NN denotes T-cell
T6275 322-330 NN denotes leukemia
T6276 330-331 -COMMA- denotes ,
T6277 332-338 NN denotes CML-T1
T6278 338-339 -COMMA- denotes ,
T6279 340-341 DT denotes a
T6280 342-358 JJ denotes bcr-abl-positive
T6281 359-365 NN denotes T-cell
T6282 366-370 NN denotes line
T6283 370-371 -COMMA- denotes ,
T6284 372-377 NN denotes K-562
T6285 377-378 -COMMA- denotes ,
T6286 379-380 DT denotes a
T6287 381-396 JJ denotes bcr-abl-positve
T6288 397-412 NN denotes erythroleukemia
T6289 412-413 -COMMA- denotes ,
T6290 414-419 NN denotes U-937
T6291 419-420 -COMMA- denotes ,
T6292 421-422 DT denotes a
T6293 423-432 JJ denotes monocytic
T6294 433-441 NN denotes leukemia
T6295 441-442 -COMMA- denotes ,
T6296 443-447 NN denotes EM-2
T6297 448-451 CC denotes and
T6298 452-459 NN denotes LAMA-84
T6299 459-460 -COMMA- denotes ,
T6300 461-476 JJ denotes bcr-abl-positve
T6301 477-484 JJ denotes myeloid
T6302 485-493 NN denotes leukemia
T6303 493-494 -COMMA- denotes ,
T6304 495-498 CC denotes but
T6305 499-502 RB denotes not
T6306 503-505 IN denotes in
T6307 506-510 NN denotes SD-1
T6308 510-511 -COMMA- denotes ,
T6309 512-513 DT denotes a
T6310 514-530 JJ denotes bcr-abl-positive
T6311 531-536 JJ denotes acute
T6312 537-550 JJ denotes lymphoblastic
T6313 551-559 NN denotes leukemia
T6314 560-561 -LRB- denotes (
T6315 561-564 JJ denotes pre
T6316 565-570 NN denotes B-ALL
T6317 570-571 -RRB- denotes )
T6318 571-572 -COMMA- denotes ,
T6319 573-582 NN denotes RPMI-8226
T6320 582-583 -COMMA- denotes ,
T6321 584-585 DT denotes a
T6322 586-594 JJ denotes multiple
T6323 595-602 NN denotes myeloma
T6324 603-606 CC denotes and
T6325 607-613 NN denotes BV-173
T6326 613-614 -COMMA- denotes ,
T6327 615-616 DT denotes a
T6328 617-633 JJ denotes bcr-abl-positive
T6329 634-640 NN denotes B-cell
T6330 641-645 NN denotes line
T6331 646-647 -LRB- denotes (
T6332 647-654 NN denotes Figures
T6333 655-657 NN denotes 1A
T6334 658-661 CC denotes and
T6335 662-664 NN denotes 5D
T6336 664-665 -RRB- denotes )
T6337 667-672 IN denotes After
T6338 673-683 NN denotes sequencing
T6339 684-686 IN denotes of
T6340 687-690 DT denotes the
T6341 691-696 NN denotes IRF-4
T6342 697-705 NN denotes promoter
T6343 705-706 -COMMA- denotes ,
T6344 707-709 PRP denotes it
T6345 710-715 MD denotes could
T6346 716-718 VB denotes be
T6347 719-727 VB denotes excluded
T6348 728-732 IN denotes that
T6349 733-740 NN denotes absence
T6350 741-743 IN denotes of
T6351 744-749 NN denotes IRF-4
T6352 750-760 NN denotes expression
T6353 761-763 IN denotes in
T6354 764-767 DT denotes any
T6355 768-770 IN denotes of
T6356 771-774 DT denotes the
T6357 775-780 JJ denotes above
T6358 781-785 NN denotes cell
T6359 786-791 NN denotes lines
T6360 792-795 VB denotes was
T6361 796-799 JJ denotes due
T6362 800-802 TO denotes to
T6363 803-810 JJ denotes genetic
T6364 811-822 NN denotes aberrations
T6365 824-831 RB denotes However
T6366 831-832 -COMMA- denotes ,
T6367 833-834 CD denotes 2
T6368 835-837 NN denotes bp
T6369 838-845 NN denotes changes
T6370 846-847 -LRB- denotes (
T6371 847-857 NN denotes nucleotide
T6372 858-863 NN denotes −1081
T6373 863-864 -COMMA- denotes ,
T6374 865-868 NN denotes T→C
T6375 869-872 CC denotes and
T6376 873-878 CD denotes −1068
T6377 878-879 -COMMA- denotes ,
T6378 880-883 NN denotes A→C
T6379 883-884 -RRB- denotes )
T6380 885-890 MD denotes could
T6381 891-893 VB denotes be
T6382 894-902 VB denotes detected
T6383 903-905 IN denotes in
T6384 906-910 CC denotes both
T6385 911-914 DT denotes the
T6386 915-929 JJ denotes IRF-4-positive
T6387 930-936 NN denotes BV-173
T6388 937-940 CC denotes and
T6389 941-944 DT denotes the
T6390 945-959 JJ denotes IRF-4-negative
T6391 960-967 NN denotes LAMA-84
T6392 967-968 -COMMA- denotes ,
T6393 969-973 NN denotes EM-2
T6394 974-977 CC denotes and
T6395 978-983 NN denotes K-562
T6396 984-985 -LRB- denotes (
T6397 985-991 NN denotes Figure
T6398 992-994 NN denotes 1B
T6399 994-995 -RRB- denotes )
T6400 997-999 IN denotes At
T6401 1000-1008 NN denotes position
T6402 1009-1013 CD denotes −116
T6403 1014-1016 DT denotes an
T6404 1017-1020 NN denotes A→C
T6405 1021-1033 NN denotes substitution
T6406 1034-1037 VB denotes was
T6407 1038-1043 VB denotes found
T6408 1044-1046 IN denotes in
T6409 1047-1051 NN denotes EM-2
T6410 1051-1052 -COMMA- denotes ,
T6411 1053-1058 NN denotes K-562
T6412 1059-1062 CC denotes and
T6413 1063-1069 NN denotes CML-T1
T6414 1069-1070 -COMMA- denotes ,
T6415 1071-1078 IN denotes whereas
T6416 1079-1085 NN denotes Jurkat
T6417 1085-1086 -COMMA- denotes ,
T6418 1087-1093 NN denotes BV-173
T6419 1094-1097 CC denotes and
T6420 1098-1102 NN denotes SD-1
T6421 1103-1112 VB denotes exhibited
T6422 1113-1114 DT denotes a
T6423 1115-1120 VB denotes mixed
T6424 1121-1124 NN denotes A/C
T6425 1125-1133 NN denotes sequence
T6426 1134-1137 CC denotes and
T6427 1138-1143 NN denotes U-937
T6428 1143-1144 -COMMA- denotes ,
T6429 1145-1152 NN denotes LAMA-84
T6430 1153-1156 CC denotes and
T6431 1157-1166 NN denotes RPMI-8226
T6432 1167-1169 DT denotes no
T6433 1170-1182 NN denotes substitution
T6434 1183-1185 IN denotes at
T6435 1186-1189 DT denotes all
T6436 1190-1191 -LRB- denotes (
T6437 1191-1197 NN denotes Figure
T6438 1198-1200 NN denotes 1B
T6439 1200-1201 -RRB- denotes )
T6440 1203-1215 RB denotes Consequently
T6441 1215-1216 -COMMA- denotes ,
T6442 1217-1222 DT denotes these
T6443 1223-1234 NN denotes alterations
T6444 1235-1238 VB denotes are
T6445 1239-1247 JJ denotes unlikely
T6446 1248-1250 TO denotes to
T6447 1251-1257 VB denotes affect
T6448 1258-1263 NN denotes IRF-4
T6449 1264-1274 NN denotes expression
T7025 1277-1285 NN denotes Increase
T7026 1286-1288 IN denotes of
T7027 1289-1294 NN denotes IRF-4
T7028 1295-1305 NN denotes expression
T7029 1306-1308 IN denotes in
T7030 1309-1322 JJ denotes hematopoietic
T7031 1323-1328 NN denotes cells
T7032 1329-1334 IN denotes after
T7033 1335-1348 VB denotes demethylating
T7034 1349-1358 NN denotes treatment
T7035 1359-1361 PRP denotes We
T7036 1362-1366 RB denotes next
T7037 1367-1375 VB denotes analyzed
T7038 1376-1383 IN denotes whether
T7039 1384-1392 NN denotes promoter
T7040 1393-1404 NN denotes methylation
T7041 1405-1410 MD denotes could
T7042 1411-1413 VB denotes be
T7043 1414-1425 JJ denotes responsible
T7044 1426-1429 IN denotes for
T7045 1430-1445 NN denotes down-regulation
T7046 1446-1448 IN denotes of
T7047 1449-1454 NN denotes IRF-4
T7048 1455-1465 NN denotes expression
T7049 1467-1468 DT denotes A
T7050 1469-1475 NN denotes region
T7051 1476-1485 VB denotes including
T7052 1486-1491 NN denotes exon1
T7053 1492-1494 IN denotes in
T7054 1495-1498 DT denotes the
T7055 1499-1504 NN denotes IRF-4
T7056 1505-1513 NN denotes promoter
T7057 1514-1523 VB denotes exhibited
T7058 1524-1525 DT denotes a
T7059 1526-1531 JJ denotes large
T7060 1532-1538 NN denotes number
T7061 1539-1541 IN denotes of
T7062 1542-1550 JJ denotes CpG-rich
T7063 1551-1560 NN denotes sequences
T7064 1561-1562 -LRB- denotes (
T7065 1562-1568 NN denotes Figure
T7066 1569-1571 NN denotes 3A
T7067 1571-1572 -RRB- denotes )
T7068 1574-1581 JJ denotes Several
T7069 1582-1590 JJ denotes chemical
T7070 1591-1601 NN denotes substances
T7071 1602-1606 JJ denotes such
T7072 1607-1609 IN denotes as
T7073 1610-1631 NN denotes 5-aza-2-deoxycytidine
T7074 1632-1633 -LRB- denotes (
T7075 1633-1638 NN denotes AzadC
T7076 1638-1639 -RRB- denotes )
T7077 1640-1642 CC denotes or
T7078 1643-1656 NN denotes 5-azacytidine
T7079 1657-1658 -LRB- denotes (
T7080 1658-1662 NN denotes AzaC
T7081 1662-1663 -RRB- denotes )
T7082 1664-1671 VB denotes inhibit
T7083 1672-1674 FW denotes de
T7084 1675-1679 FW denotes novo
T7085 1680-1683 CC denotes and
T7086 1684-1695 NN denotes maintenance
T7087 1696-1707 NN denotes methylation
T7088 1707-1708 -COMMA- denotes ,
T7089 1709-1712 CC denotes and
T7090 1713-1717 RB denotes thus
T7091 1718-1721 MD denotes can
T7092 1722-1724 VB denotes be
T7093 1725-1729 VB denotes used
T7094 1730-1732 TO denotes to
T7095 1733-1740 VB denotes discern
T7096 1741-1749 NN denotes promoter
T7097 1750-1761 NN denotes methylation
T7098 1762-1763 -LRB- denotes (
T7099 1763-1768 CD denotes 32,33
T7100 1768-1769 -RRB- denotes )
T7101 1771-1773 PRP denotes We
T7102 1774-1778 VB denotes used
T7103 1779-1784 NN denotes AzadC
T7104 1785-1787 TO denotes to
T7105 1788-1796 VB denotes generate
T7106 1797-1809 JJ denotes unmethylated
T7107 1810-1813 NN denotes DNA
T7108 1815-1816 DT denotes A
T7109 1817-1819 CD denotes 72
T7110 1820-1821 NN denotes h
T7111 1822-1837 NN denotes AzadC-treatment
T7112 1838-1846 VB denotes resulted
T7113 1847-1849 IN denotes in
T7114 1850-1851 DT denotes a
T7115 1852-1875 JJ denotes concentration-dependent
T7116 1876-1886 NN denotes activation
T7117 1887-1889 IN denotes of
T7118 1890-1895 NN denotes IRF-4
T7119 1896-1909 NN denotes transcription
T7120 1910-1912 IN denotes in
T7121 1913-1919 NN denotes Jurkat
T7122 1920-1923 CC denotes and
T7123 1924-1930 NN denotes CML-T1
T7124 1931-1938 NN denotes T-cells
T7125 1939-1941 RB denotes as
T7126 1942-1946 RB denotes well
T7127 1947-1949 IN denotes as
T7128 1950-1952 IN denotes in
T7129 1953-1958 NN denotes U-937
T7130 1958-1959 -COMMA- denotes ,
T7131 1960-1965 NN denotes K-562
T7132 1966-1969 CC denotes and
T7133 1970-1974 NN denotes EM-2
T7134 1975-1979 NN denotes cell
T7135 1980-1985 NN denotes lines
T7136 1986-1987 -LRB- denotes (
T7137 1987-1993 NN denotes Figure
T7138 1994-1996 NN denotes 2A
T7139 1996-1997 -RRB- denotes )
T7140 1999-2004 NN denotes IRF-4
T7141 2005-2018 NN denotes transcription
T7142 2019-2022 VB denotes was
T7143 2023-2030 VB denotes induced
T7144 2031-2033 IN denotes in
T7145 2034-2035 DT denotes a
T7146 2036-2050 JJ denotes time-dependent
T7147 2051-2057 NN denotes manner
T7148 2058-2061 CC denotes and
T7149 2062-2065 VB denotes was
T7150 2066-2074 VB denotes observed
T7151 2075-2077 RB denotes as
T7152 2078-2083 RB denotes early
T7153 2084-2086 IN denotes as
T7154 2087-2089 CD denotes 24
T7155 2090-2091 NN denotes h
T7156 2092-2097 IN denotes after
T7157 2098-2107 NN denotes treatment
T7158 2108-2112 IN denotes with
T7159 2113-2118 NN denotes AzadC
T7160 2119-2122 CC denotes and
T7161 2123-2132 VB denotes increased
T7162 2133-2137 IN denotes over
T7163 2138-2142 NN denotes time
T7164 2143-2148 IN denotes until
T7165 2149-2151 CD denotes 72
T7166 2152-2153 NN denotes h
T7167 2154-2155 -LRB- denotes (
T7168 2155-2161 NN denotes Figure
T7169 2162-2164 NN denotes 2B
T7170 2164-2165 -RRB- denotes )
T7171 2167-2171 NN denotes Time
T7172 2172-2175 CC denotes and
T7173 2176-2184 NN denotes strength
T7174 2185-2187 IN denotes of
T7175 2188-2191 DT denotes the
T7176 2192-2202 NN denotes appearance
T7177 2203-2205 IN denotes of
T7178 2206-2211 NN denotes IRF-4
T7179 2212-2223 NN denotes transcripts
T7180 2224-2230 VB denotes varied
T7181 2231-2236 IN denotes among
T7182 2237-2241 NN denotes cell
T7183 2242-2247 NN denotes lines
T7184 2247-2248 -COMMA- denotes ,
T7185 2249-2253 FW denotes i.e.
T7186 2254-2260 NN denotes CML-T1
T7187 2261-2270 VB denotes responded
T7188 2271-2280 JJ denotes strongest
T7189 2281-2283 TO denotes to
T7190 2284-2299 NN denotes AzadC-treatment
T7191 2300-2301 -LRB- denotes (
T7192 2301-2305 NN denotes data
T7193 2306-2309 RB denotes not
T7194 2310-2315 VB denotes shown
T7195 2315-2316 -RRB- denotes )
T7196 2318-2320 IN denotes In
T7197 2321-2325 NN denotes line
T7198 2326-2330 IN denotes with
T7199 2331-2335 DT denotes this
T7200 2335-2336 -COMMA- denotes ,
T7201 2337-2352 NN denotes AzadC-treatment
T7202 2353-2355 IN denotes of
T7203 2356-2362 NN denotes CML-T1
T7204 2363-2366 CC denotes and
T7205 2367-2374 NN denotes LAMA-84
T7206 2375-2380 NN denotes cells
T7207 2381-2385 RB denotes also
T7208 2386-2396 VB denotes translated
T7209 2397-2399 IN denotes in
T7210 2400-2402 DT denotes an
T7211 2403-2412 NN denotes induction
T7212 2413-2415 IN denotes of
T7213 2416-2421 NN denotes IRF-4
T7214 2422-2429 NN denotes protein
T7215 2430-2440 NN denotes expression
T7216 2441-2442 -LRB- denotes (
T7217 2442-2448 NN denotes Figure
T7218 2449-2451 NN denotes 2C
T7219 2451-2452 -RRB- denotes )
T7220 2454-2465 RB denotes Accordingly
T7221 2465-2466 -COMMA- denotes ,
T7222 2467-2476 NN denotes treatment
T7223 2477-2479 IN denotes of
T7224 2480-2483 DT denotes the
T7225 2484-2498 JJ denotes IRF-4-positive
T7226 2499-2503 NN denotes cell
T7227 2504-2508 NN denotes line
T7228 2509-2515 NN denotes BV-173
T7229 2515-2516 -COMMA- denotes ,
T7230 2517-2521 NN denotes SD-1
T7231 2522-2525 CC denotes and
T7232 2526-2535 NN denotes RPMI-8226
T7233 2536-2540 IN denotes with
T7234 2541-2546 NN denotes AzadC
T7235 2547-2550 VB denotes had
T7236 2551-2553 DT denotes no
T7237 2554-2560 NN denotes effect
T7238 2561-2563 IN denotes on
T7239 2564-2569 NN denotes IRF-4
T7240 2570-2580 NN denotes expression
T7241 2581-2582 -LRB- denotes (
T7242 2582-2588 NN denotes Figure
T7243 2589-2591 NN denotes 2D
T7244 2591-2592 -RRB- denotes )
T7245 2594-2599 EX denotes There
T7246 2600-2603 VB denotes was
T7247 2604-2606 DT denotes no
T7248 2607-2617 NN denotes difference
T7249 2618-2620 IN denotes in
T7250 2621-2624 DT denotes the
T7251 2625-2632 NN denotes effects
T7252 2633-2635 IN denotes of
T7253 2636-2640 NN denotes AzaC
T7254 2641-2647 IN denotes versus
T7255 2648-2653 NN denotes AzadC
T7256 2653-2654 -COMMA- denotes ,
T7257 2655-2657 IN denotes as
T7258 2658-2662 DT denotes both
T7259 2663-2672 VB denotes increased
T7260 2673-2676 DT denotes the
T7261 2677-2682 NN denotes IRF-4
T7262 2683-2687 NN denotes mRNA
T7263 2688-2693 NN denotes level
T7264 2694-2696 IN denotes in
T7265 2697-2703 NN denotes CML-T1
T7266 2704-2709 NN denotes cells
T7267 2710-2712 RB denotes as
T7268 2713-2717 RB denotes well
T7269 2718-2719 -LRB- denotes (
T7270 2719-2723 NN denotes data
T7271 2724-2727 RB denotes not
T7272 2728-2733 VB denotes shown
T7273 2733-2734 -RRB- denotes )
T7274 2736-2740 DT denotes This
T7275 2741-2748 VB denotes implied
T7276 2749-2753 IN denotes that
T7277 2754-2762 NN denotes promoter
T7278 2763-2774 NN denotes methylation
T7279 2775-2778 MD denotes may
T7280 2779-2786 VB denotes control
T7281 2787-2792 NN denotes IRF-4
T7282 2793-2803 NN denotes expression
T7283 2803-2804 -COMMA- denotes ,
T7284 2805-2808 CC denotes but
T7285 2809-2811 DT denotes an
T7286 2812-2823 JJ denotes alternative
T7287 2824-2835 NN denotes explanation
T7288 2836-2839 MD denotes may
T7289 2840-2842 VB denotes be
T7290 2843-2853 NN denotes activation
T7291 2854-2856 IN denotes of
T7292 2857-2865 JJ denotes positive
T7293 2866-2881 JJ denotes transcriptional
T7294 2882-2892 NN denotes regulators
T7295 2893-2895 IN denotes of
T7296 2896-2901 NN denotes IRF-4
T7297 2902-2904 IN denotes by
T7298 2905-2910 NN denotes AzadC
T7299 2911-2912 -LRB- denotes (
T7300 2912-2914 CC denotes or
T7301 2915-2919 NN denotes AzaC
T7302 2919-2920 -RRB- denotes )
T7852 2923-2944 JJ denotes Methylation-sensitive
T7853 2945-2952 NN denotes enzymes
T7854 2953-2955 VB denotes do
T7855 2956-2959 RB denotes not
T7856 2960-2963 VB denotes cut
T7857 2964-2972 JJ denotes specific
T7858 2973-2978 NN denotes sites
T7859 2979-2981 IN denotes in
T7860 2982-2985 DT denotes the
T7861 2986-2991 NN denotes IRF-4
T7862 2992-3000 NN denotes promoter
T7863 3001-3003 IN denotes in
T7864 3004-3017 JJ denotes hematopoietic
T7865 3018-3023 NN denotes cells
T7866 3024-3026 TO denotes To
T7867 3027-3034 RB denotes further
T7868 3035-3046 VB denotes investigate
T7869 3047-3055 NN denotes promoter
T7870 3056-3067 NN denotes methylation
T7871 3068-3070 IN denotes as
T7872 3071-3072 DT denotes a
T7873 3073-3083 JJ denotes regulatory
T7874 3084-3093 NN denotes mechanism
T7875 3094-3096 IN denotes of
T7876 3097-3102 NN denotes IRF-4
T7877 3103-3107 NN denotes gene
T7878 3108-3118 NN denotes expression
T7879 3118-3119 -COMMA- denotes ,
T7880 3120-3142 NN denotes restriction-PCR-assays
T7881 3143-3147 VB denotes were
T7882 3148-3157 VB denotes performed
T7883 3158-3159 -LRB- denotes (
T7884 3159-3164 CD denotes 20,24
T7885 3164-3165 -RRB- denotes )
T7886 3165-3166 -COMMA- denotes ,
T7887 3167-3172 WRB denotes where
T7888 3173-3177 RB denotes only
T7889 3178-3188 VB denotes methylated
T7890 3189-3192 NN denotes DNA
T7891 3193-3198 MD denotes would
T7892 3199-3202 RB denotes not
T7893 3203-3205 VB denotes be
T7894 3206-3209 VB denotes cut
T7895 3210-3218 VB denotes enabling
T7896 3219-3229 JJ denotes subsequent
T7897 3230-3233 NN denotes PCR
T7898 3234-3247 NN denotes amplification
T7899 3248-3251 CC denotes and
T7900 3252-3256 NN denotes vice
T7901 3257-3262 NN denotes versa
T7902 3264-3271 JJ denotes Genomic
T7903 3272-3275 NN denotes DNA
T7904 3276-3280 IN denotes from
T7905 3281-3289 JJ denotes leukemic
T7906 3290-3295 NN denotes cells
T7907 3296-3302 NN denotes Jurkat
T7908 3302-3303 -COMMA- denotes ,
T7909 3304-3310 NN denotes CML-T1
T7910 3310-3311 -COMMA- denotes ,
T7911 3312-3317 NN denotes U-937
T7912 3317-3318 -COMMA- denotes ,
T7913 3319-3324 NN denotes K-562
T7914 3324-3325 -COMMA- denotes ,
T7915 3326-3330 NN denotes EM-2
T7916 3331-3334 CC denotes and
T7917 3335-3341 NN denotes BV-173
T7918 3342-3345 VB denotes was
T7919 3346-3354 VB denotes digested
T7920 3355-3359 IN denotes with
T7921 3360-3363 DT denotes the
T7922 3364-3385 JJ denotes methylation-sensitive
T7923 3386-3393 NN denotes enzymes
T7924 3394-3399 NN denotes HpaII
T7925 3399-3400 -COMMA- denotes ,
T7926 3401-3409 NN denotes Bsh1236I
T7927 3410-3413 CC denotes and
T7928 3414-3431 NN denotes HaeII-isochizomer
T7929 3432-3440 NN denotes Bsp143II
T7930 3442-3447 NNP denotes EcoRI
T7931 3447-3448 -COMMA- denotes ,
T7932 3449-3454 WDT denotes which
T7933 3455-3458 VB denotes has
T7934 3459-3461 DT denotes no
T7935 3462-3473 NN denotes recognition
T7936 3474-3478 NN denotes site
T7937 3479-3485 IN denotes within
T7938 3486-3489 DT denotes the
T7939 3490-3495 NN denotes IRF-4
T7940 3496-3504 NN denotes promoter
T7941 3504-3505 -COMMA- denotes ,
T7942 3506-3509 CC denotes and
T7943 3510-3513 DT denotes the
T7944 3514-3535 JJ denotes methylation-resistant
T7945 3536-3542 NN denotes enzyme
T7946 3543-3547 NN denotes MspI
T7947 3548-3554 VB denotes served
T7948 3555-3557 IN denotes as
T7949 3558-3566 NN denotes controls
T7950 3568-3571 CD denotes Two
T7951 3572-3580 JJ denotes separate
T7952 3581-3594 NN denotes amplification
T7953 3595-3604 NN denotes reactions
T7954 3605-3609 VB denotes were
T7955 3610-3619 VB denotes performed
T7956 3619-3620 -COMMA- denotes ,
T7957 3621-3631 VB denotes generating
T7958 3632-3635 CD denotes two
T7959 3636-3645 NN denotes fragments
T7960 3645-3646 -COMMA- denotes ,
T7961 3647-3649 NN denotes F1
T7962 3650-3653 CC denotes and
T7963 3654-3656 NN denotes F2
T7964 3657-3658 -LRB- denotes (
T7965 3658-3664 NN denotes Figure
T7966 3665-3667 NN denotes 3A
T7967 3667-3668 -RRB- denotes )
T7968 3670-3675 IN denotes After
T7969 3676-3685 NN denotes digestion
T7970 3686-3690 IN denotes with
T7971 3691-3696 NN denotes HpaII
T7972 3697-3700 CC denotes and
T7973 3701-3709 NN denotes Bsp143II
T7974 3710-3711 DT denotes a
T7975 3712-3722 JJ denotes sufficient
T7976 3723-3726 NN denotes PCR
T7977 3727-3740 NN denotes amplification
T7978 3741-3743 IN denotes of
T7979 3744-3746 NN denotes F1
T7980 3747-3750 CC denotes and
T7981 3751-3753 NN denotes F2
T7982 3754-3757 VB denotes was
T7983 3758-3766 VB denotes detected
T7984 3767-3769 IN denotes in
T7985 3770-3773 NN denotes DNA
T7986 3774-3778 IN denotes from
T7987 3779-3793 JJ denotes IRF-4-negative
T7988 3794-3800 NN denotes Jurkat
T7989 3800-3801 -COMMA- denotes ,
T7990 3802-3808 NN denotes CML-T1
T7991 3808-3809 -COMMA- denotes ,
T7992 3810-3815 NN denotes U-937
T7993 3815-3816 -COMMA- denotes ,
T7994 3817-3822 NN denotes K-562
T7995 3823-3826 CC denotes and
T7996 3827-3831 NN denotes EM-2
T7997 3832-3837 NN denotes cells
T7998 3837-3838 -COMMA- denotes ,
T7999 3839-3849 VB denotes suggesting
T8000 3850-3851 DT denotes a
T8001 3852-3860 NN denotes promoter
T8002 3861-3872 NN denotes methylation
T8003 3873-3874 -LRB- denotes (
T8004 3874-3877 CC denotes and
T8005 3878-3889 NN denotes restriction
T8006 3890-3900 NN denotes protection
T8007 3900-3901 -RRB- denotes )
T8008 3902-3904 IN denotes at
T8009 3905-3908 DT denotes the
T8010 3909-3919 JJ denotes respective
T8011 3920-3931 NN denotes recognition
T8012 3932-3937 NN denotes sites
T8013 3938-3939 -LRB- denotes (
T8014 3939-3945 NN denotes Figure
T8015 3946-3948 NN denotes 3B
T8016 3949-3952 CC denotes and
T8017 3953-3954 NN denotes C
T8018 3954-3955 -RRB- denotes )
T8019 3957-3964 RB denotes Notably
T8020 3964-3965 -COMMA- denotes ,
T8021 3966-3968 IN denotes in
T8022 3969-3983 JJ denotes IRF-4-positive
T8023 3984-3988 NN denotes SD-1
T8024 3989-3994 NN denotes cells
T8025 3995-4004 NN denotes digestion
T8026 4005-4009 IN denotes with
T8027 4010-4013 DT denotes the
T8028 4014-4035 JJ denotes methylation-sensitive
T8029 4036-4043 NN denotes enzymes
T8030 4044-4054 RB denotes completely
T8031 4055-4064 VB denotes inhibited
T8032 4065-4078 NN denotes amplification
T8033 4079-4081 IN denotes of
T8034 4082-4084 NN denotes F1
T8035 4085-4088 CC denotes and
T8036 4089-4091 NN denotes F2
T8037 4093-4095 IN denotes In
T8038 4096-4110 JJ denotes IRF-4-positive
T8039 4111-4117 NN denotes BV-173
T8040 4118-4123 NN denotes cells
T8041 4124-4125 DT denotes a
T8042 4126-4131 NN denotes HpaII
T8043 4131-4132 -COMMA- denotes ,
T8044 4133-4136 CC denotes but
T8045 4137-4140 RB denotes not
T8046 4141-4142 DT denotes a
T8047 4143-4151 NN denotes Bsh1236I
T8048 4152-4161 NN denotes digestion
T8049 4161-4162 -COMMA- denotes ,
T8050 4163-4176 RB denotes significantly
T8051 4177-4184 VB denotes reduced
T8052 4185-4188 DT denotes the
T8053 4189-4200 JJ denotes amplifiable
T8054 4201-4204 NN denotes DNA
T8055 4205-4212 NN denotes message
T8056 4213-4215 IN denotes of
T8057 4216-4218 NN denotes F2
T8058 4219-4220 -LRB- denotes (
T8059 4220-4226 NN denotes Figure
T8060 4227-4229 NN denotes 3C
T8061 4229-4230 -RRB- denotes )
T8062 4230-4231 -COMMA- denotes ,
T8063 4232-4239 IN denotes whereas
T8064 4240-4253 NN denotes amplification
T8065 4254-4256 IN denotes of
T8066 4257-4259 NN denotes F1
T8067 4260-4263 VB denotes was
T8068 4264-4267 RB denotes not
T8069 4268-4276 VB denotes affected
T8070 4277-4278 -LRB- denotes (
T8071 4278-4284 NN denotes Figure
T8072 4285-4287 NN denotes 3B
T8073 4287-4288 -RRB- denotes )
T8074 4290-4294 DT denotes This
T8075 4295-4302 VB denotes implied
T8076 4303-4307 IN denotes that
T8077 4308-4313 NN denotes IRF-4
T8078 4314-4327 NN denotes transcription
T8079 4328-4330 IN denotes in
T8080 4331-4335 NN denotes SD-1
T8081 4336-4339 CC denotes and
T8082 4340-4346 NN denotes BV-173
T8083 4347-4352 NN denotes cells
T8084 4353-4355 VB denotes is
T8085 4356-4366 VB denotes associated
T8086 4367-4371 IN denotes with
T8087 4372-4376 JJ denotes less
T8088 4377-4385 NN denotes promoter
T8089 4386-4397 NN denotes methylation
T8090 4398-4399 -LRB- denotes (
T8091 4399-4401 IN denotes in
T8092 4402-4408 NN denotes BV-173
T8093 4409-4419 RB denotes especially
T8094 4420-4422 IN denotes at
T8095 4423-4428 NN denotes HpaII
T8096 4429-4434 NN denotes sites
T8097 4434-4435 -RRB- denotes )
T8098 4436-4438 IN denotes as
T8099 4439-4447 VB denotes compared
T8100 4448-4452 IN denotes with
T8101 4453-4456 DT denotes the
T8102 4457-4463 VB denotes tested
T8103 4464-4478 JJ denotes IRF-4-negative
T8104 4479-4484 NN denotes cells
T8578 4487-4495 JJ denotes Specific
T8579 4496-4499 NN denotes CpG
T8580 4500-4505 NN denotes sites
T8581 4506-4508 IN denotes in
T8582 4509-4512 DT denotes the
T8583 4513-4518 NN denotes IRF-4
T8584 4519-4527 NN denotes promoter
T8585 4528-4531 VB denotes are
T8586 4532-4542 VB denotes methylated
T8587 4543-4545 IN denotes in
T8588 4546-4559 JJ denotes hematopoietic
T8589 4560-4565 NN denotes cells
T8590 4566-4568 IN denotes In
T8591 4569-4574 NN denotes order
T8592 4575-4577 TO denotes to
T8593 4578-4585 RB denotes exactly
T8594 4586-4589 VB denotes map
T8595 4590-4593 DT denotes the
T8596 4594-4605 NN denotes methylation
T8597 4606-4611 NN denotes sites
T8598 4612-4618 IN denotes within
T8599 4619-4622 DT denotes the
T8600 4623-4628 NN denotes IRF-4
T8601 4629-4637 NN denotes promoter
T8602 4637-4638 -COMMA- denotes ,
T8603 4639-4641 PRP denotes we
T8604 4642-4649 VB denotes treated
T8605 4650-4653 NN denotes DNA
T8606 4654-4656 IN denotes of
T8607 4657-4663 NN denotes Jurkat
T8608 4663-4664 -COMMA- denotes ,
T8609 4665-4671 NN denotes CML-T1
T8610 4671-4672 -COMMA- denotes ,
T8611 4673-4678 NN denotes U-937
T8612 4678-4679 -COMMA- denotes ,
T8613 4680-4685 NN denotes K-562
T8614 4686-4689 CC denotes and
T8615 4690-4694 NN denotes EM-2
T8616 4695-4700 NN denotes cells
T8617 4701-4703 RB denotes as
T8618 4704-4708 RB denotes well
T8619 4709-4711 IN denotes as
T8620 4712-4714 IN denotes of
T8621 4715-4719 NN denotes SD-1
T8622 4719-4720 -COMMA- denotes ,
T8623 4721-4730 NN denotes RPMI-8226
T8624 4731-4734 CC denotes and
T8625 4735-4741 NN denotes BV-173
T8626 4742-4749 NN denotes control
T8627 4750-4755 NN denotes cells
T8628 4756-4760 IN denotes with
T8629 4761-4770 NN denotes bisulfite
T8630 4770-4771 -COMMA- denotes ,
T8631 4772-4777 WDT denotes which
T8632 4778-4788 RB denotes chemically
T8633 4789-4797 VB denotes converts
T8634 4798-4810 JJ denotes unmethylated
T8635 4811-4819 NN denotes cytosine
T8636 4820-4822 TO denotes to
T8637 4823-4829 NN denotes uracil
T8638 4829-4830 -COMMA- denotes ,
T8639 4831-4838 IN denotes whereas
T8640 4839-4841 PRP denotes it
T8641 4842-4845 VB denotes has
T8642 4846-4848 DT denotes no
T8643 4849-4855 NN denotes effect
T8644 4856-4858 IN denotes on
T8645 4859-4869 VB denotes methylated
T8646 4870-4878 NN denotes cytosine
T8647 4878-4879 -COMMA- denotes ,
T8648 4880-4884 FW denotes i.e.
T8649 4885-4887 IN denotes in
T8650 4888-4891 NN denotes CpG
T8651 4892-4893 -LRB- denotes (
T8652 4893-4895 CD denotes 34
T8653 4895-4896 -RRB- denotes )
T8654 4898-4902 DT denotes This
T8655 4903-4912 NN denotes technique
T8656 4913-4915 VB denotes is
T8657 4916-4926 RB denotes especially
T8658 4927-4933 JJ denotes useful
T8659 4934-4937 IN denotes for
T8660 4938-4947 NN denotes detection
T8661 4948-4950 IN denotes of
T8662 4951-4958 JJ denotes unknown
T8663 4959-4970 NN denotes methylation
T8664 4971-4979 NN denotes patterns
T8665 4981-4984 NN denotes PCR
T8666 4985-4998 NN denotes amplification
T8667 4998-4999 -COMMA- denotes ,
T8668 5000-5007 NN denotes cloning
T8669 5008-5011 CC denotes and
T8670 5012-5022 NN denotes sequencing
T8671 5023-5025 IN denotes of
T8672 5026-5029 DT denotes the
T8673 5030-5047 JJ denotes bisulfite-treated
T8674 5048-5051 NN denotes DNA
T8675 5052-5058 VB denotes showed
T8676 5059-5060 DT denotes a
T8677 5061-5069 JJ denotes specific
T8678 5070-5081 NN denotes methylation
T8679 5082-5089 NN denotes pattern
T8680 5090-5092 IN denotes of
T8681 5093-5096 DT denotes the
T8682 5097-5105 VB denotes analyzed
T8683 5106-5108 CD denotes 62
T8684 5109-5112 NN denotes CpG
T8685 5113-5118 NN denotes sites
T8686 5119-5121 IN denotes in
T8687 5122-5125 DT denotes all
T8688 5126-5130 NN denotes cell
T8689 5131-5136 NN denotes lines
T8690 5137-5138 -LRB- denotes (
T8691 5138-5144 NN denotes Figure
T8692 5145-5146 CD denotes 4
T8693 5147-5150 CC denotes and
T8694 5151-5156 NN denotes Table
T8695 5157-5158 CD denotes 1
T8696 5158-5159 -RRB- denotes )
T8697 5161-5163 IN denotes In
T8698 5164-5171 JJ denotes general
T8699 5171-5172 -COMMA- denotes ,
T8700 5173-5176 DT denotes the
T8701 5177-5190 JJ denotes methylational
T8702 5191-5197 NN denotes status
T8703 5198-5204 VB denotes ranged
T8704 5205-5209 IN denotes from
T8705 5210-5213 CD denotes one
T8706 5214-5218 NN denotes cell
T8707 5219-5223 NN denotes line
T8708 5224-5228 IN denotes with
T8709 5229-5230 DT denotes a
T8710 5231-5237 RB denotes nearly
T8711 5238-5252 JJ denotes non-methylated
T8712 5253-5258 NN denotes IRF-4
T8713 5259-5267 NN denotes promoter
T8714 5268-5269 -LRB- denotes (
T8715 5269-5273 NN denotes SD-1
T8716 5273-5274 -COMMA- denotes ,
T8717 5275-5289 JJ denotes IRF-4-positive
T8718 5289-5290 -RRB- denotes )
T8719 5291-5293 TO denotes to
T8720 5294-5295 DT denotes a
T8721 5296-5306 RB denotes completely
T8722 5307-5317 VB denotes methylated
T8723 5318-5323 NN denotes IRF-4
T8724 5324-5332 NN denotes promoter
T8725 5333-5335 IN denotes in
T8726 5336-5342 NN denotes CML-T1
T8727 5343-5344 -LRB- denotes (
T8728 5344-5358 JJ denotes IRF-4-negative
T8729 5358-5359 -RRB- denotes )
T8730 5361-5374 RB denotes Interestingly
T8731 5374-5375 -COMMA- denotes ,
T8732 5376-5379 DT denotes the
T8733 5380-5390 NN denotes percentage
T8734 5391-5393 IN denotes of
T8735 5394-5397 NN denotes CpG
T8736 5398-5409 NN denotes methylation
T8737 5410-5412 IN denotes in
T8738 5413-5416 DT denotes the
T8739 5417-5422 NN denotes IRF-4
T8740 5423-5431 NN denotes promoter
T8741 5432-5436 IN denotes from
T8742 5437-5451 JJ denotes IRF-4-positive
T8743 5452-5457 NN denotes cells
T8744 5458-5461 VB denotes was
T8745 5462-5466 RB denotes very
T8746 5467-5470 JJ denotes low
T8747 5471-5472 -LRB- denotes (
T8748 5472-5476 NN denotes mean
T8749 5477-5479 CD denotes 24
T8750 5479-5480 NN denotes %
T8751 5480-5481 -RRB- denotes )
T8752 5482-5484 IN denotes as
T8753 5485-5493 VB denotes compared
T8754 5494-5498 IN denotes with
T8755 5499-5513 JJ denotes IRF-4-negative
T8756 5514-5519 NN denotes cells
T8757 5520-5521 -LRB- denotes (
T8758 5521-5525 NN denotes mean
T8759 5526-5528 CD denotes 94
T8760 5528-5529 NN denotes %
T8761 5529-5530 -RRB- denotes )
T8762 5531-5532 -LRB- denotes (
T8763 5532-5538 NN denotes Figure
T8764 5539-5541 NN denotes 4A
T8765 5542-5545 CC denotes and
T8766 5546-5551 JJ denotes Table
T8767 5552-5553 CD denotes 1
T8768 5553-5554 -RRB- denotes )
T8769 5556-5557 DT denotes A
T8770 5558-5567 NN denotes 5′-region
T8771 5568-5569 -LRB- denotes (
T8772 5569-5571 NN denotes R1
T8773 5571-5572 -RRB- denotes )
T8774 5573-5577 IN denotes with
T8775 5578-5580 CD denotes 13
T8776 5581-5596 VB denotes hypermethylated
T8777 5597-5600 NN denotes CpG
T8778 5601-5606 NN denotes sites
T8779 5607-5608 -LRB- denotes (
T8780 5608-5612 JJ denotes mean
T8781 5613-5619 NN denotes number
T8782 5620-5622 IN denotes of
T8783 5623-5633 VB denotes methylated
T8784 5634-5640 NN denotes clones
T8785 5641-5644 CD denotes 5.5
T8786 5645-5647 IN denotes of
T8787 5648-5649 CD denotes 8
T8788 5650-5654 IN denotes with
T8789 5655-5657 CD denotes 77
T8790 5657-5658 NN denotes %
T8791 5659-5669 VB denotes methylated
T8792 5670-5674 NN denotes CpGs
T8793 5674-5675 -RRB- denotes )
T8794 5676-5679 VB denotes was
T8795 5680-5685 VB denotes found
T8796 5686-5688 IN denotes in
T8797 5689-5693 JJ denotes most
T8798 5694-5699 NN denotes cells
T8799 5700-5701 -LRB- denotes (
T8800 5701-5707 IN denotes except
T8801 5708-5712 NN denotes SD-1
T8802 5713-5716 CC denotes and
T8803 5717-5726 NN denotes RPMI-8226
T8804 5726-5727 -RRB- denotes )
T8805 5728-5731 CC denotes and
T8806 5732-5733 DT denotes a
T8807 5734-5743 NN denotes 3′-region
T8808 5744-5745 -LRB- denotes (
T8809 5745-5747 NN denotes R3
T8810 5747-5748 -RRB- denotes )
T8811 5749-5751 IN denotes of
T8812 5752-5753 CD denotes 6
T8813 5754-5768 VB denotes hypomethylated
T8814 5769-5772 NN denotes CpG
T8815 5773-5778 NN denotes sites
T8816 5779-5780 -LRB- denotes (
T8817 5780-5784 JJ denotes mean
T8818 5785-5791 NN denotes number
T8819 5792-5794 IN denotes of
T8820 5795-5805 VB denotes methylated
T8821 5806-5812 NN denotes clones
T8822 5813-5816 CD denotes 1.7
T8823 5817-5819 IN denotes of
T8824 5820-5821 CD denotes 8
T8825 5822-5826 IN denotes with
T8826 5827-5829 CD denotes 33
T8827 5829-5830 NN denotes %
T8828 5831-5841 VB denotes methylated
T8829 5842-5846 NN denotes CpGs
T8830 5846-5847 -RRB- denotes )
T8831 5848-5851 VB denotes was
T8832 5852-5857 VB denotes found
T8833 5858-5860 IN denotes in
T8834 5861-5865 JJ denotes most
T8835 5866-5871 NN denotes cells
T8836 5872-5873 -LRB- denotes (
T8837 5873-5879 IN denotes except
T8838 5880-5886 NN denotes CML-T1
T8839 5887-5890 CC denotes and
T8840 5891-5896 NN denotes U-937
T8841 5896-5897 -RRB- denotes )
T8842 5898-5899 -LRB- denotes (
T8843 5899-5905 NN denotes Figure
T8844 5906-5908 NN denotes 4A
T8845 5909-5912 CC denotes and
T8846 5913-5918 JJ denotes Table
T8847 5919-5920 CD denotes 1
T8848 5920-5921 -RRB- denotes )
T8849 5923-5935 RB denotes Intriguingly
T8850 5935-5936 -COMMA- denotes ,
T8851 5937-5938 DT denotes a
T8852 5939-5946 NN denotes stretch
T8853 5947-5949 IN denotes of
T8854 5950-5952 CD denotes 13
T8855 5953-5956 NN denotes CpG
T8856 5957-5962 NN denotes sites
T8857 5963-5964 -LRB- denotes (
T8858 5964-5965 -SHARP- denotes #
T8859 5965-5970 CD denotes 10–22
T8860 5970-5971 -COLON- denotes ;
T8861 5972-5974 NN denotes R2
T8862 5974-5975 -RRB- denotes )
T8863 5976-5979 VB denotes was
T8864 5980-5988 VB denotes detected
T8865 5989-5991 IN denotes in
T8866 5992-5999 IN denotes between
T8867 6000-6005 DT denotes these
T8868 6006-6013 NN denotes regions
T8869 6013-6014 -COMMA- denotes ,
T8870 6015-6020 WDT denotes which
T8871 6021-6025 VB denotes were
T8872 6026-6032 RB denotes highly
T8873 6033-6043 VB denotes methylated
T8874 6044-6046 IN denotes in
T8875 6047-6061 JJ denotes IRF-4-negative
T8876 6062-6063 -LRB- denotes (
T8877 6063-6067 JJ denotes mean
T8878 6068-6074 NN denotes number
T8879 6075-6077 IN denotes of
T8880 6078-6088 VB denotes methylated
T8881 6089-6095 NN denotes clones
T8882 6096-6099 CD denotes 7.1
T8883 6100-6102 IN denotes of
T8884 6103-6104 CD denotes 8
T8885 6105-6109 IN denotes with
T8886 6110-6112 CD denotes 89
T8887 6112-6113 NN denotes %
T8888 6114-6124 VB denotes methylated
T8889 6125-6129 NN denotes CpGs
T8890 6129-6130 -RRB- denotes )
T8891 6131-6134 CC denotes but
T8892 6135-6142 RB denotes totally
T8893 6143-6157 JJ denotes non-methylated
T8894 6158-6160 IN denotes in
T8895 6161-6175 JJ denotes IRF-4-positive
T8896 6176-6181 NN denotes cells
T8897 6182-6183 -LRB- denotes (
T8898 6183-6189 NN denotes Figure
T8899 6190-6192 NN denotes 4A
T8900 6193-6196 CC denotes and
T8901 6197-6198 NN denotes B
T8902 6198-6199 -RRB- denotes )
T8903 6201-6212 RB denotes Furthermore
T8904 6212-6213 -COMMA- denotes ,
T8905 6214-6219 CD denotes three
T8906 6220-6223 NN denotes CpG
T8907 6224-6229 NN denotes sites
T8908 6230-6232 IN denotes at
T8909 6233-6236 DT denotes the
T8910 6237-6239 NN denotes 5′
T8911 6240-6243 NN denotes end
T8912 6244-6245 -LRB- denotes (
T8913 6245-6246 -SHARP- denotes #
T8914 6246-6248 CD denotes 54
T8915 6248-6249 -COMMA- denotes ,
T8916 6250-6252 CD denotes 56
T8917 6252-6253 -COMMA- denotes ,
T8918 6254-6256 CD denotes 58
T8919 6256-6257 -RRB- denotes )
T8920 6258-6261 CC denotes and
T8921 6262-6265 CD denotes two
T8922 6266-6269 NN denotes CpG
T8923 6270-6276 NN denotes motifs
T8924 6277-6279 IN denotes at
T8925 6280-6283 DT denotes the
T8926 6284-6286 NN denotes 3′
T8927 6287-6290 NN denotes end
T8928 6291-6292 -LRB- denotes (
T8929 6292-6293 -SHARP- denotes #
T8930 6293-6294 CD denotes 1
T8931 6294-6295 -COMMA- denotes ,
T8932 6296-6297 CD denotes 2
T8933 6297-6298 -RRB- denotes )
T8934 6299-6305 VB denotes showed
T8935 6306-6310 DT denotes this
T8936 6311-6317 JJ denotes direct
T8937 6318-6329 NN denotes correlation
T8938 6330-6337 IN denotes between
T8939 6338-6342 JJ denotes high
T8940 6343-6354 NN denotes methylation
T8941 6355-6361 NN denotes status
T8942 6362-6365 CC denotes and
T8943 6366-6373 NN denotes absence
T8944 6374-6376 IN denotes of
T8945 6377-6382 NN denotes IRF-4
T8946 6383-6393 NN denotes expression
T8947 6395-6397 IN denotes In
T8948 6398-6406 NN denotes addition
T8949 6406-6407 -COMMA- denotes ,
T8950 6408-6411 CD denotes two
T8951 6412-6415 NN denotes CpG
T8952 6416-6421 NN denotes sites
T8953 6422-6429 JJ denotes located
T8954 6430-6432 IN denotes in
T8955 6433-6434 DT denotes a
T8956 6435-6439 NN denotes NFκB
T8957 6440-6441 -LRB- denotes (
T8958 6441-6442 -SHARP- denotes #
T8959 6442-6444 CD denotes 48
T8960 6444-6445 -RRB- denotes )
T8961 6446-6449 CC denotes and
T8962 6450-6451 DT denotes a
T8963 6452-6455 NN denotes SP1
T8964 6456-6463 NN denotes element
T8965 6464-6465 -LRB- denotes (
T8966 6465-6466 -SHARP- denotes #
T8967 6466-6468 CD denotes 45
T8968 6468-6469 -RRB- denotes )
T8969 6470-6473 VB denotes are
T8970 6474-6478 RB denotes less
T8971 6479-6489 VB denotes methylated
T8972 6490-6492 IN denotes in
T8973 6493-6507 JJ denotes IRF-4-positive
T8974 6508-6512 IN denotes than
T8975 6513-6515 IN denotes in
T8976 6516-6530 JJ denotes IRF-4-negative
T8977 6531-6536 NN denotes cells
T8978 6537-6538 -LRB- denotes (
T8979 6538-6542 JJ denotes mean
T8980 6543-6549 NN denotes number
T8981 6550-6552 IN denotes of
T8982 6553-6563 VB denotes methylated
T8983 6564-6570 NN denotes clones
T8984 6570-6571 -COLON- denotes :
T8985 6572-6575 CD denotes 1/8
T8986 6576-6582 CC denotes versus
T8987 6583-6586 CD denotes 8/8
T8988 6586-6587 -RRB- denotes )
T8989 6589-6594 DT denotes These
T8990 6595-6602 NN denotes results
T8991 6603-6611 VB denotes indicate
T8992 6612-6615 DT denotes the
T8993 6616-6627 NN denotes involvement
T8994 6628-6630 IN denotes of
T8995 6631-6634 NN denotes CpG
T8996 6635-6646 NN denotes methylation
T8997 6647-6649 IN denotes in
T8998 6650-6653 DT denotes the
T8999 6654-6664 NN denotes regulation
T9000 6665-6667 IN denotes of
T9001 6668-6673 NN denotes IRF-4
T9002 6674-6684 NN denotes expression
T9003 6685-6687 IN denotes in
T9004 6688-6696 JJ denotes leukemic
T9005 6697-6702 NN denotes cells
T9706 6705-6707 FW denotes In
T9707 6708-6713 FW denotes vitro
T9708 6714-6725 NN denotes methylation
T9709 6726-6728 IN denotes of
T9710 6729-6731 DT denotes an
T9711 6732-6737 NN denotes IRF-4
T9712 6738-6755 JJ denotes promoter-reporter
T9713 6756-6765 NN denotes construct
T9714 6766-6775 VB denotes decreases
T9715 6776-6779 PRP-DOLLAR- denotes its
T9716 6780-6788 NN denotes activity
T9717 6789-6791 TO denotes To
T9718 6792-6799 VB denotes provide
T9719 6800-6808 NN denotes evidence
T9720 6809-6812 IN denotes for
T9721 6813-6814 DT denotes a
T9722 6815-6821 JJ denotes direct
T9723 6822-6828 NN denotes effect
T9724 6829-6831 IN denotes of
T9725 6832-6845 JJ denotes methylational
T9726 6846-6852 NN denotes status
T9727 6853-6855 IN denotes on
T9728 6856-6861 NN denotes IRF-4
T9729 6862-6870 NN denotes promoter
T9730 6871-6879 NN denotes activity
T9731 6880-6882 PRP denotes we
T9732 6883-6892 VB denotes performed
T9733 6893-6901 NN denotes reporter
T9734 6902-6906 NN denotes gene
T9735 6907-6913 NN denotes assays
T9736 6914-6918 IN denotes with
T9737 6919-6924 NN denotes IRF-4
T9738 6925-6933 NN denotes promoter
T9739 6934-6944 NN denotes constructs
T9740 6945-6951 IN denotes before
T9741 6952-6955 CC denotes and
T9742 6956-6961 IN denotes after
T9743 6962-6967 PRP-DOLLAR- denotes their
T9744 6968-6970 FW denotes in
T9745 6971-6976 FW denotes vitro
T9746 6977-6988 NN denotes methylation
T9747 6990-6991 DT denotes A
T9748 6992-7000 JJ denotes complete
T9749 7001-7012 NN denotes methylation
T9750 7013-7015 IN denotes of
T9751 7016-7021 DT denotes these
T9752 7022-7032 NN denotes constructs
T9753 7033-7036 VB denotes was
T9754 7037-7044 VB denotes checked
T9755 7045-7048 IN denotes via
T9756 7049-7060 NN denotes restriction
T9757 7061-7067 NN denotes assays
T9758 7068-7072 IN denotes with
T9759 7073-7094 JJ denotes methylation-sensitive
T9760 7095-7108 NN denotes endonucleases
T9761 7109-7110 -LRB- denotes (
T9762 7110-7116 NN denotes Figure
T9763 7117-7119 NN denotes 5A
T9764 7119-7120 -RRB- denotes )
T9765 7122-7134 RB denotes Intriguingly
T9766 7134-7135 -COMMA- denotes ,
T9767 7136-7147 NN denotes methylation
T9768 7148-7150 IN denotes of
T9769 7151-7154 DT denotes the
T9770 7155-7160 NN denotes IRF-4
T9771 7161-7169 NN denotes promoter
T9772 7170-7183 RB denotes significantly
T9773 7184-7193 VB denotes decreased
T9774 7194-7202 NN denotes promoter
T9775 7203-7211 NN denotes activity
T9776 7212-7214 IN denotes in
T9777 7215-7229 JJ denotes IRF-4-positive
T9778 7230-7234 NN denotes SD-1
T9779 7235-7240 NN denotes cells
T9780 7241-7243 IN denotes by
T9781 7244-7248 CD denotes 85.0
T9782 7248-7249 NN denotes %
T9783 7250-7251 -LRB- denotes (
T9784 7251-7257 NN denotes Figure
T9785 7258-7260 NN denotes 5B
T9786 7260-7261 -RRB- denotes )
T9787 7263-7266 DT denotes The
T9788 7267-7276 JJ denotes silencing
T9789 7277-7283 NN denotes effect
T9790 7284-7286 IN denotes of
T9791 7287-7290 NN denotes CpG
T9792 7291-7302 NN denotes methylation
T9793 7303-7306 VB denotes was
T9794 7307-7310 RB denotes not
T9795 7311-7321 JJ denotes restricted
T9796 7322-7324 TO denotes to
T9797 7325-7339 JJ denotes IRF-4-positive
T9798 7340-7345 NN denotes cells
T9799 7345-7346 -COMMA- denotes ,
T9800 7347-7352 IN denotes since
T9801 7353-7355 FW denotes in
T9802 7356-7361 FW denotes vitro
T9803 7362-7373 NN denotes methylation
T9804 7374-7377 VB denotes led
T9805 7378-7380 TO denotes to
T9806 7381-7382 DT denotes a
T9807 7383-7387 CD denotes 92.9
T9808 7387-7388 NN denotes %
T9809 7389-7399 NN denotes abrogation
T9810 7400-7402 IN denotes of
T9811 7403-7411 NN denotes promoter
T9812 7412-7420 NN denotes activity
T9813 7421-7423 IN denotes in
T9814 7424-7438 JJ denotes IRF-4-negative
T9815 7439-7445 NN denotes Jurkat
T9816 7446-7451 NN denotes cells
T9817 7452-7453 -LRB- denotes (
T9818 7453-7459 NN denotes Figure
T9819 7460-7462 NN denotes 5C
T9820 7462-7463 -RRB- denotes )
T9821 7465-7467 IN denotes In
T9822 7468-7476 NN denotes contrast
T9823 7476-7477 -COMMA- denotes ,
T9824 7478-7485 NN denotes control
T9825 7486-7497 NN denotes methylation
T9826 7498-7500 IN denotes of
T9827 7501-7502 DT denotes a
T9828 7503-7511 NN denotes reporter
T9829 7512-7521 NN denotes construct
T9830 7522-7526 IN denotes with
T9831 7527-7528 DT denotes a
T9832 7529-7538 JJ denotes different
T9833 7539-7547 NN denotes promoter
T9834 7548-7549 -LRB- denotes (
T9835 7549-7553 NN denotes FasL
T9836 7553-7554 -RRB- denotes )
T9837 7555-7557 RB denotes as
T9838 7558-7562 RB denotes well
T9839 7563-7565 IN denotes as
T9840 7566-7568 DT denotes an
T9841 7569-7574 JJ denotes empty
T9842 7575-7581 NN denotes vector
T9843 7582-7585 VB denotes had
T9844 7586-7588 DT denotes no
T9845 7589-7595 NN denotes effect
T9846 7596-7598 IN denotes on
T9847 7599-7602 DT denotes the
T9848 7603-7611 NN denotes reporter
T9849 7612-7620 NN denotes activity
T9850 7621-7622 -LRB- denotes (
T9851 7622-7626 NN denotes data
T9852 7627-7630 RB denotes not
T9853 7631-7636 VB denotes shown
T9854 7636-7637 -RRB- denotes )
T9855 7639-7644 DT denotes These
T9856 7645-7649 NN denotes data
T9857 7650-7656 VB denotes proved
T9858 7657-7658 DT denotes a
T9859 7659-7665 JJ denotes direct
T9860 7666-7677 NN denotes association
T9861 7678-7685 IN denotes between
T9862 7686-7697 NN denotes methylation
T9863 7698-7701 CC denotes and
T9864 7702-7710 NN denotes activity
T9865 7711-7713 IN denotes of
T9866 7714-7717 DT denotes the
T9867 7718-7723 NN denotes IRF-4
T9868 7724-7732 NN denotes promoter
T10256 7735-7739 NN denotes mRNA
T10257 7740-7750 NN denotes expression
T10258 7751-7753 IN denotes of
T10259 7754-7757 NN denotes DNA
T10260 7758-7776 NN denotes methyltransferases
T10261 7777-7780 CC denotes and
T10262 7781-7799 NN denotes methyl-CpG-binding
T10263 7800-7808 NN denotes proteins
T10264 7809-7812 MD denotes may
T10265 7813-7816 RB denotes not
T10266 7817-7819 VB denotes be
T10267 7820-7830 VB denotes associated
T10268 7831-7835 IN denotes with
T10269 7836-7841 NN denotes IRF-4
T10270 7842-7850 NN denotes promoter
T10271 7851-7862 NN denotes methylation
T10272 7863-7868 IN denotes Since
T10273 7869-7878 NN denotes abundance
T10274 7879-7881 IN denotes of
T10275 7882-7886 NN denotes DNMT
T10276 7887-7890 CC denotes and
T10277 7891-7894 NN denotes MBP
T10278 7895-7905 VB denotes contribute
T10279 7906-7908 TO denotes to
T10280 7909-7917 NN denotes promoter
T10281 7918-7928 NN denotes regulation
T10282 7929-7932 IN denotes via
T10283 7933-7944 NN denotes methylation
T10284 7945-7946 -LRB- denotes (
T10285 7946-7954 CD denotes 25,26,28
T10286 7954-7955 -RRB- denotes )
T10287 7955-7956 -COMMA- denotes ,
T10288 7957-7959 PRP denotes we
T10289 7960-7967 VB denotes studied
T10290 7968-7973 PRP-DOLLAR- denotes their
T10291 7974-7978 NN denotes mRNA
T10292 7979-7989 NN denotes expression
T10293 7990-7992 TO denotes to
T10294 7993-8004 VB denotes investigate
T10295 8005-8006 DT denotes a
T10296 8007-8015 JJ denotes possible
T10297 8016-8025 NN denotes mechanism
T10298 8026-8029 IN denotes for
T10299 8030-8033 DT denotes the
T10300 8034-8042 VB denotes observed
T10301 8043-8054 NN denotes methylation
T10302 8055-8066 NN denotes differences
T10303 8067-8069 IN denotes in
T10304 8070-8073 DT denotes the
T10305 8074-8079 NN denotes IRF-4
T10306 8080-8088 NN denotes promoter
T10307 8090-8092 TO denotes To
T10308 8093-8097 DT denotes this
T10309 8098-8101 NN denotes end
T10310 8101-8102 -COMMA- denotes ,
T10311 8103-8105 PRP denotes we
T10312 8106-8109 VB denotes did
T10313 8110-8113 RB denotes not
T10314 8114-8120 VB denotes detect
T10315 8121-8122 DT denotes a
T10316 8123-8134 JJ denotes significant
T10317 8135-8145 NN denotes difference
T10318 8146-8148 IN denotes in
T10319 8149-8153 NN denotes DNMT
T10320 8154-8155 -LRB- denotes (
T10321 8155-8160 NN denotes DNMT1
T10322 8160-8161 -COMMA- denotes ,
T10323 8162-8168 NN denotes DNMT3A
T10324 8169-8172 CC denotes and
T10325 8173-8179 NN denotes DNMT3B
T10326 8179-8180 -RRB- denotes )
T10327 8181-8183 CC denotes or
T10328 8184-8187 NN denotes MBP
T10329 8188-8189 -LRB- denotes (
T10330 8189-8193 NN denotes MBD1
T10331 8193-8194 -COMMA- denotes ,
T10332 8195-8199 NN denotes MBD2
T10333 8199-8200 -COMMA- denotes ,
T10334 8201-8205 NN denotes MBD4
T10335 8206-8209 CC denotes and
T10336 8210-8214 NN denotes MeCP
T10337 8214-8215 -RRB- denotes )
T10338 8216-8220 NN denotes mRNA
T10339 8221-8231 NN denotes expression
T10340 8232-8239 IN denotes between
T10341 8240-8254 JJ denotes IRF-4-positive
T10342 8255-8258 CC denotes and
T10343 8259-8268 JJ denotes -negative
T10344 8269-8274 NN denotes cells
T10345 8275-8276 -LRB- denotes (
T10346 8276-8282 NN denotes Figure
T10347 8283-8285 NN denotes 5D
T10348 8285-8286 -RRB- denotes )
T10349 8288-8290 IN denotes In
T10350 8291-8295 NN denotes fact
T10351 8295-8296 -COMMA- denotes ,
T10352 8297-8300 DT denotes all
T10353 8301-8309 VB denotes analyzed
T10354 8310-8315 NN denotes cells
T10355 8316-8319 VB denotes had
T10356 8320-8328 JJ denotes moderate
T10357 8329-8331 TO denotes to
T10358 8332-8336 JJ denotes high
T10359 8337-8341 NN denotes mRNA
T10360 8342-8348 NN denotes levels
T10361 8349-8351 IN denotes of
T10362 8352-8357 DT denotes these
T10363 8358-8364 VB denotes tested
T10364 8365-8374 NN denotes DNMT/MBPs
T10365 8375-8378 CC denotes and
T10366 8379-8390 NN denotes differences
T10367 8391-8393 IN denotes in
T10368 8394-8404 NN denotes expression
T10369 8405-8409 VB denotes were
T10370 8410-8413 RB denotes not
T10371 8414-8424 VB denotes correlated
T10372 8425-8429 IN denotes with
T10373 8430-8435 NN denotes IRF-4
T10374 8436-8442 NN denotes status
T10375 8444-8449 DT denotes These
T10376 8450-8457 NN denotes results
T10377 8458-8466 VB denotes indicate
T10378 8467-8468 DT denotes a
T10379 8469-8477 JJ denotes distinct
T10380 8478-8483 NN denotes cause
T10381 8484-8486 IN denotes of
T10382 8487-8490 DT denotes the
T10383 8491-8502 NN denotes methylation
T10384 8503-8514 NN denotes differences
T10385 8515-8517 IN denotes in
T10386 8518-8532 JJ denotes IRF-4-positive
T10387 8533-8536 CC denotes and
T10388 8537-8546 JJ denotes -negative
T10389 8547-8552 NN denotes cells
T10390 8553-8559 RB denotes rather
T10391 8560-8564 IN denotes than
T10392 8565-8572 NN denotes changes
T10393 8573-8575 IN denotes in
T10394 8576-8579 DT denotes the
T10395 8580-8584 NN denotes DNMT
T10396 8585-8588 CC denotes and
T10397 8589-8592 NN denotes MBP
T10398 8593-8597 NN denotes mRNA
T10399 8598-8611 NN denotes transcription
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R5178 T6221 T6230 arg1Of Absence,due
R5179 T6224 T6222 arg2Of expression,of
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R5186 T6230 T6231 arg1Of due,to
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R5189 T6234 T6235 arg1Of We,have
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R5193 T6239 T6237 arg2Of lack,demonstrated
R5194 T6239 T6238 arg1Of lack,a
R5195 T6239 T6240 arg1Of lack,of
R5196 T6239 T6243 arg1Of lack,in
R5197 T6239 T6248 arg1Of lack,in
R5198 T6242 T6240 arg2Of expression,of
R5199 T6242 T6241 arg1Of expression,IRF-4
R5200 T6243 T6246 arg1Of in,and
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R5205 T6250 T6248 arg2Of T-cells,in
R5206 T6250 T6249 arg1Of T-cells,CML
R5207 T6250 T6251 arg1Of T-cells,(
R5208 T6252 T6251 arg2Of 3,(
R5209 T6253 T6251 arg3Of ),(
R5210 T6256 T6257 arg1Of we,demonstrate
R5211 T6257 T6254 arg1Of demonstrate,Here
R5212 T6257 T6255 arg1Of demonstrate,","
R5213 T6259 T6258 arg1Of absence,the
R5214 T6259 T6260 arg1Of absence,of
R5215 T6259 T6306 arg1Of absence,in
R5216 T6259 T6318 arg1Of absence,","
R5217 T6259 T6324 arg1Of absence,and
R5218 T6260 T6304 arg1Of of,but
R5219 T6262 T6260 arg2Of expression,of
R5220 T6262 T6261 arg1Of expression,IRF-4
R5221 T6262 T6263 arg1Of expression,in
R5222 T6262 T6278 arg1Of expression,","
R5223 T6262 T6289 arg1Of expression,","
R5224 T6262 T6291 arg1Of expression,","
R5225 T6267 T6263 arg2Of lines,in
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R5228 T6267 T6266 arg1Of lines,cell
R5229 T6267 T6268 arg1Of lines,","
R5230 T6267 T6270 arg1Of lines,as
R5231 T6270 T6269 arg1Of as,such
R5232 T6271 T6270 arg2Of Jurkat,as
R5233 T6271 T6272 arg1Of Jurkat,","
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R5235 T6275 T6272 arg2Of leukemia,","
R5236 T6275 T6273 arg1Of leukemia,a
R5237 T6275 T6274 arg1Of leukemia,T-cell
R5238 T6277 T6276 arg2Of CML-T1,","
R5239 T6282 T6278 arg2Of line,","
R5240 T6282 T6279 arg1Of line,a
R5241 T6282 T6280 arg1Of line,bcr-abl-positive
R5242 T6282 T6281 arg1Of line,T-cell
R5243 T6282 T6283 arg1Of line,","
R5244 T6282 T6285 arg1Of line,","
R5245 T6284 T6283 arg2Of K-562,","
R5246 T6288 T6285 arg2Of erythroleukemia,","
R5247 T6288 T6286 arg1Of erythroleukemia,a
R5248 T6288 T6287 arg1Of erythroleukemia,bcr-abl-positve
R5249 T6290 T6289 arg2Of U-937,","
R5250 T6294 T6295 arg1Of leukemia,","
R5251 T6295 T6297 arg1Of ",",and
R5252 T6296 T6295 arg2Of EM-2,","
R5253 T6297 T6293 arg1Of and,monocytic
R5254 T6297 T6299 arg1Of and,","
R5255 T6298 T6297 arg2Of LAMA-84,and
R5256 T6299 T6291 arg2Of ",",","
R5257 T6299 T6292 arg1Of ",",a
R5258 T6302 T6299 arg2Of leukemia,","
R5259 T6302 T6300 arg1Of leukemia,bcr-abl-positve
R5260 T6302 T6301 arg1Of leukemia,myeloid
R5261 T6304 T6303 arg1Of but,","
R5262 T6306 T6304 arg2Of in,but
R5263 T6306 T6305 arg1Of in,not
R5264 T6307 T6306 arg2Of SD-1,in
R5265 T6307 T6308 arg1Of SD-1,","
R5266 T6313 T6308 arg2Of leukemia,","
R5267 T6313 T6309 arg1Of leukemia,a
R5268 T6313 T6310 arg1Of leukemia,bcr-abl-positive
R5269 T6313 T6311 arg1Of leukemia,acute
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R5271 T6313 T6314 arg1Of leukemia,(
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R5274 T6317 T6314 arg3Of ),(
R5275 T6319 T6318 arg2Of RPMI-8226,","
R5276 T6319 T6320 arg1Of RPMI-8226,","
R5277 T6323 T6320 arg2Of myeloma,","
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R5280 T6324 T6257 arg2Of and,demonstrate
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R5283 T6330 T6326 arg2Of line,","
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R5286 T6330 T6329 arg1Of line,B-cell
R5287 T6330 T6331 arg1Of line,(
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R5289 T6334 T6331 arg2Of and,(
R5290 T6334 T6332 arg1Of and,Figures
R5291 T6335 T6334 arg2Of 5D,and
R5292 T6336 T6331 arg3Of ),(
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R5295 T6342 T6339 arg2Of promoter,of
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R5298 T6344 T6345 arg1Of it,could
R5299 T6344 T6346 arg1Of it,be
R5300 T6346 T6337 arg1Of be,After
R5301 T6346 T6343 arg1Of be,","
R5302 T6346 T6345 arg2Of be,could
R5303 T6346 T6353 arg1Of be,in
R5304 T6349 T6346 arg2Of absence,be
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R5306 T6349 T6348 arg1Of absence,that
R5307 T6349 T6350 arg1Of absence,of
R5308 T6352 T6350 arg2Of expression,of
R5309 T6352 T6351 arg1Of expression,IRF-4
R5310 T6354 T6355 arg1Of any,of
R5311 T6354 T6360 arg1Of any,was
R5312 T6354 T6361 arg1Of any,due
R5313 T6359 T6355 arg2Of lines,of
R5314 T6359 T6356 arg1Of lines,the
R5315 T6359 T6357 arg1Of lines,above
R5316 T6359 T6358 arg1Of lines,cell
R5317 T6360 T6353 arg2Of was,in
R5318 T6361 T6360 arg2Of due,was
R5319 T6361 T6362 arg1Of due,to
R5320 T6364 T6362 arg2Of aberrations,to
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R5322 T6369 T6367 arg1Of changes,2
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R5324 T6369 T6370 arg1Of changes,(
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R5326 T6369 T6381 arg1Of changes,be
R5327 T6369 T6382 arg2Of changes,detected
R5328 T6372 T6371 arg1Of −1081,nucleotide
R5329 T6372 T6373 arg1Of −1081,","
R5330 T6373 T6375 arg1Of ",",and
R5331 T6374 T6373 arg2Of T→C,","
R5332 T6375 T6370 arg2Of and,(
R5333 T6375 T6377 arg1Of and,","
R5334 T6376 T6375 arg2Of −1068,and
R5335 T6378 T6377 arg2Of A→C,","
R5336 T6379 T6370 arg3Of ),(
R5337 T6382 T6365 arg1Of detected,However
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R5340 T6382 T6381 arg2Of detected,be
R5341 T6382 T6383 arg1Of detected,in
R5342 T6387 T6385 arg1Of BV-173,the
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R5344 T6387 T6388 arg1Of BV-173,and
R5345 T6388 T6383 arg2Of and,in
R5346 T6388 T6384 arg1Of and,both
R5347 T6388 T6392 arg1Of and,","
R5348 T6391 T6388 arg2Of LAMA-84,and
R5349 T6391 T6389 arg1Of LAMA-84,the
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R5351 T6393 T6394 arg1Of EM-2,and
R5352 T6394 T6392 arg2Of and,","
R5353 T6394 T6396 arg1Of and,(
R5354 T6395 T6394 arg2Of K-562,and
R5355 T6398 T6396 arg2Of 1B,(
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R5357 T6399 T6396 arg3Of ),(
R5358 T6401 T6400 arg2Of position,At
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R5360 T6405 T6403 arg1Of substitution,an
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R5369 T6410 T6412 arg1Of ",",and
R5370 T6411 T6410 arg2Of K-562,","
R5371 T6412 T6408 arg2Of and,in
R5372 T6413 T6412 arg2Of CML-T1,and
R5373 T6415 T6414 arg1Of whereas,","
R5374 T6416 T6417 arg1Of Jurkat,","
R5375 T6417 T6419 arg1Of ",",and
R5376 T6418 T6417 arg2Of BV-173,","
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R5380 T6422 T6431 arg1Of a,RPMI-8226
R5381 T6425 T6423 arg2Of sequence,mixed
R5382 T6425 T6424 arg1Of sequence,A/C
R5383 T6425 T6426 arg1Of sequence,and
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R5386 T6426 T6434 arg1Of and,at
R5387 T6426 T6436 arg1Of and,(
R5388 T6427 T6428 arg1Of U-937,","
R5389 T6428 T6430 arg1Of ",",and
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R5391 T6430 T6426 arg2Of and,and
R5392 T6431 T6430 arg2Of RPMI-8226,and
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R5394 T6433 T6432 arg1Of substitution,no
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R5396 T6438 T6436 arg2Of 1B,(
R5397 T6438 T6437 arg1Of 1B,Figure
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R5399 T6443 T6442 arg1Of alterations,these
R5400 T6443 T6444 arg1Of alterations,are
R5401 T6443 T6445 arg1Of alterations,unlikely
R5402 T6443 T6447 arg1Of alterations,affect
R5403 T6444 T6440 arg1Of are,Consequently
R5404 T6444 T6441 arg1Of are,","
R5405 T6445 T6444 arg2Of unlikely,are
R5406 T6447 T6445 arg2Of affect,unlikely
R5407 T6447 T6446 arg1Of affect,to
R5408 T6449 T6447 arg2Of expression,affect
R5409 T6449 T6448 arg1Of expression,IRF-4
R5814 T7025 T7026 arg1Of Increase,of
R5815 T7025 T7029 arg1Of Increase,in
R5816 T7025 T7032 arg1Of Increase,after
R5817 T7028 T7026 arg2Of expression,of
R5818 T7028 T7027 arg1Of expression,IRF-4
R5819 T7031 T7029 arg2Of cells,in
R5820 T7031 T7030 arg1Of cells,hematopoietic
R5821 T7033 T7032 arg2Of demethylating,after
R5822 T7034 T7033 arg2Of treatment,demethylating
R5823 T7035 T7037 arg1Of We,analyzed
R5824 T7037 T7036 arg1Of analyzed,next
R5825 T7040 T7039 arg1Of methylation,promoter
R5826 T7040 T7041 arg1Of methylation,could
R5827 T7040 T7042 arg1Of methylation,be
R5828 T7040 T7043 arg1Of methylation,responsible
R5829 T7042 T7037 arg2Of be,analyzed
R5830 T7042 T7038 arg1Of be,whether
R5831 T7042 T7041 arg2Of be,could
R5832 T7043 T7042 arg2Of responsible,be
R5833 T7043 T7044 arg1Of responsible,for
R5834 T7045 T7044 arg2Of down-regulation,for
R5835 T7045 T7046 arg1Of down-regulation,of
R5836 T7048 T7046 arg2Of expression,of
R5837 T7048 T7047 arg1Of expression,IRF-4
R5838 T7050 T7049 arg1Of region,A
R5839 T7050 T7051 arg1Of region,including
R5840 T7050 T7057 arg1Of region,exhibited
R5841 T7052 T7051 arg2Of exon1,including
R5842 T7052 T7053 arg1Of exon1,in
R5843 T7056 T7053 arg2Of promoter,in
R5844 T7056 T7054 arg1Of promoter,the
R5845 T7056 T7055 arg1Of promoter,IRF-4
R5846 T7060 T7057 arg2Of number,exhibited
R5847 T7060 T7058 arg1Of number,a
R5848 T7060 T7059 arg1Of number,large
R5849 T7060 T7061 arg1Of number,of
R5850 T7063 T7061 arg2Of sequences,of
R5851 T7063 T7062 arg1Of sequences,CpG-rich
R5852 T7063 T7064 arg1Of sequences,(
R5853 T7066 T7064 arg2Of 3A,(
R5854 T7066 T7065 arg1Of 3A,Figure
R5855 T7067 T7064 arg3Of ),(
R5856 T7070 T7068 arg1Of substances,Several
R5857 T7070 T7069 arg1Of substances,chemical
R5858 T7070 T7072 arg1Of substances,as
R5859 T7070 T7082 arg1Of substances,inhibit
R5860 T7070 T7091 arg1Of substances,can
R5861 T7070 T7092 arg1Of substances,be
R5862 T7070 T7093 arg2Of substances,used
R5863 T7072 T7071 arg1Of as,such
R5864 T7073 T7074 arg1Of 5-aza-2-deoxycytidine,(
R5865 T7073 T7077 arg1Of 5-aza-2-deoxycytidine,or
R5866 T7075 T7074 arg2Of AzadC,(
R5867 T7076 T7074 arg3Of ),(
R5868 T7077 T7072 arg2Of or,as
R5869 T7078 T7077 arg2Of 5-azacytidine,or
R5870 T7078 T7079 arg1Of 5-azacytidine,(
R5871 T7080 T7079 arg2Of AzaC,(
R5872 T7081 T7079 arg3Of ),(
R5873 T7082 T7089 arg1Of inhibit,and
R5874 T7084 T7083 arg1Of novo,de
R5875 T7087 T7082 arg2Of methylation,inhibit
R5876 T7087 T7084 arg1Of methylation,novo
R5877 T7087 T7085 arg1Of methylation,and
R5878 T7087 T7086 arg1Of methylation,maintenance
R5879 T7089 T7088 arg1Of and,","
R5880 T7093 T7089 arg2Of used,and
R5881 T7093 T7090 arg1Of used,thus
R5882 T7093 T7091 arg2Of used,can
R5883 T7093 T7092 arg2Of used,be
R5884 T7095 T7093 arg3Of discern,used
R5885 T7095 T7094 arg1Of discern,to
R5886 T7097 T7095 arg2Of methylation,discern
R5887 T7097 T7096 arg1Of methylation,promoter
R5888 T7097 T7098 arg1Of methylation,(
R5889 T7099 T7098 arg2Of "32,33",(
R5890 T7100 T7098 arg3Of ),(
R5891 T7101 T7102 arg1Of We,used
R5892 T7101 T7105 arg1Of We,generate
R5893 T7103 T7102 arg2Of AzadC,used
R5894 T7105 T7102 arg3Of generate,used
R5895 T7105 T7104 arg1Of generate,to
R5896 T7107 T7105 arg2Of DNA,generate
R5897 T7107 T7106 arg1Of DNA,unmethylated
R5898 T7111 T7108 arg1Of AzadC-treatment,A
R5899 T7111 T7109 arg1Of AzadC-treatment,72
R5900 T7111 T7110 arg1Of AzadC-treatment,h
R5901 T7111 T7112 arg1Of AzadC-treatment,resulted
R5902 T7112 T7113 arg1Of resulted,in
R5903 T7112 T7128 arg1Of resulted,in
R5904 T7113 T7127 arg1Of in,as
R5905 T7116 T7113 arg2Of activation,in
R5906 T7116 T7114 arg1Of activation,a
R5907 T7116 T7115 arg1Of activation,concentration-dependent
R5908 T7116 T7117 arg1Of activation,of
R5909 T7116 T7120 arg1Of activation,in
R5910 T7119 T7117 arg2Of transcription,of
R5911 T7119 T7118 arg1Of transcription,IRF-4
R5912 T7121 T7122 arg1Of Jurkat,and
R5913 T7123 T7122 arg2Of CML-T1,and
R5914 T7124 T7120 arg2Of T-cells,in
R5915 T7124 T7121 arg1Of T-cells,Jurkat
R5916 T7124 T7123 arg1Of T-cells,CML-T1
R5917 T7127 T7125 arg1Of as,as
R5918 T7127 T7126 arg1Of as,well
R5919 T7128 T7127 arg2Of in,as
R5920 T7129 T7130 arg1Of U-937,","
R5921 T7130 T7132 arg1Of ",",and
R5922 T7131 T7130 arg2Of K-562,","
R5923 T7132 T7128 arg2Of and,in
R5924 T7135 T7132 arg2Of lines,and
R5925 T7135 T7133 arg1Of lines,EM-2
R5926 T7135 T7134 arg1Of lines,cell
R5927 T7135 T7136 arg1Of lines,(
R5928 T7138 T7136 arg2Of 2A,(
R5929 T7138 T7137 arg1Of 2A,Figure
R5930 T7139 T7136 arg3Of ),(
R5931 T7141 T7140 arg1Of transcription,IRF-4
R5932 T7141 T7142 arg1Of transcription,was
R5933 T7141 T7143 arg2Of transcription,induced
R5934 T7141 T7149 arg1Of transcription,was
R5935 T7141 T7150 arg2Of transcription,observed
R5936 T7141 T7161 arg1Of transcription,increased
R5937 T7143 T7142 arg2Of induced,was
R5938 T7143 T7144 arg1Of induced,in
R5939 T7143 T7148 arg1Of induced,and
R5940 T7147 T7144 arg2Of manner,in
R5941 T7147 T7145 arg1Of manner,a
R5942 T7147 T7146 arg1Of manner,time-dependent
R5943 T7150 T7149 arg2Of observed,was
R5944 T7150 T7152 arg1Of observed,early
R5945 T7150 T7156 arg1Of observed,after
R5946 T7150 T7160 arg1Of observed,and
R5947 T7152 T7151 arg1Of early,as
R5948 T7152 T7153 arg1Of early,as
R5949 T7155 T7153 arg2Of h,as
R5950 T7155 T7154 arg1Of h,24
R5951 T7157 T7156 arg2Of treatment,after
R5952 T7157 T7158 arg1Of treatment,with
R5953 T7159 T7158 arg2Of AzadC,with
R5954 T7160 T7148 arg2Of and,and
R5955 T7161 T7160 arg2Of increased,and
R5956 T7161 T7162 arg1Of increased,over
R5957 T7161 T7164 arg1Of increased,until
R5958 T7163 T7162 arg2Of time,over
R5959 T7166 T7164 arg2Of h,until
R5960 T7166 T7165 arg1Of h,72
R5961 T7166 T7167 arg1Of h,(
R5962 T7169 T7167 arg2Of 2B,(
R5963 T7169 T7168 arg1Of 2B,Figure
R5964 T7170 T7167 arg3Of ),(
R5965 T7171 T7172 arg1Of Time,and
R5966 T7172 T7174 arg1Of and,of
R5967 T7172 T7180 arg1Of and,varied
R5968 T7173 T7172 arg2Of strength,and
R5969 T7176 T7174 arg2Of appearance,of
R5970 T7176 T7175 arg1Of appearance,the
R5971 T7176 T7177 arg1Of appearance,of
R5972 T7179 T7177 arg2Of transcripts,of
R5973 T7179 T7178 arg1Of transcripts,IRF-4
R5974 T7180 T7181 arg1Of varied,among
R5975 T7180 T7184 arg1Of varied,","
R5976 T7183 T7181 arg2Of lines,among
R5977 T7183 T7182 arg1Of lines,cell
R5978 T7186 T7185 arg1Of CML-T1,i.e.
R5979 T7186 T7187 arg1Of CML-T1,responded
R5980 T7187 T7184 arg2Of responded,","
R5981 T7187 T7189 arg1Of responded,to
R5982 T7188 T7187 arg2Of strongest,responded
R5983 T7190 T7189 arg2Of AzadC-treatment,to
R5984 T7190 T7191 arg1Of AzadC-treatment,(
R5985 T7192 T7191 arg2Of data,(
R5986 T7192 T7194 arg2Of data,shown
R5987 T7194 T7193 arg1Of shown,not
R5988 T7195 T7191 arg3Of ),(
R5989 T7197 T7196 arg2Of line,In
R5990 T7197 T7198 arg1Of line,with
R5991 T7199 T7198 arg2Of this,with
R5992 T7201 T7202 arg1Of AzadC-treatment,of
R5993 T7201 T7208 arg1Of AzadC-treatment,translated
R5994 T7203 T7204 arg1Of CML-T1,and
R5995 T7205 T7204 arg2Of LAMA-84,and
R5996 T7206 T7202 arg2Of cells,of
R5997 T7206 T7203 arg1Of cells,CML-T1
R5998 T7206 T7205 arg1Of cells,LAMA-84
R5999 T7208 T7196 arg1Of translated,In
R6000 T7208 T7200 arg1Of translated,","
R6001 T7208 T7207 arg1Of translated,also
R6002 T7208 T7209 arg1Of translated,in
R6003 T7211 T7209 arg2Of induction,in
R6004 T7211 T7210 arg1Of induction,an
R6005 T7211 T7212 arg1Of induction,of
R6006 T7215 T7212 arg2Of expression,of
R6007 T7215 T7213 arg1Of expression,IRF-4
R6008 T7215 T7214 arg1Of expression,protein
R6009 T7215 T7216 arg1Of expression,(
R6010 T7218 T7216 arg2Of 2C,(
R6011 T7218 T7217 arg1Of 2C,Figure
R6012 T7219 T7216 arg3Of ),(
R6013 T7222 T7223 arg1Of treatment,of
R6014 T7222 T7229 arg1Of treatment,","
R6015 T7228 T7223 arg2Of BV-173,of
R6016 T7228 T7224 arg1Of BV-173,the
R6017 T7228 T7225 arg1Of BV-173,IRF-4-positive
R6018 T7228 T7226 arg1Of BV-173,cell
R6019 T7228 T7227 arg1Of BV-173,line
R6020 T7229 T7235 arg1Of ",",had
R6021 T7230 T7231 arg1Of SD-1,and
R6022 T7231 T7229 arg2Of and,","
R6023 T7231 T7233 arg1Of and,with
R6024 T7232 T7231 arg2Of RPMI-8226,and
R6025 T7234 T7233 arg2Of AzadC,with
R6026 T7235 T7220 arg1Of had,Accordingly
R6027 T7235 T7221 arg1Of had,","
R6028 T7237 T7235 arg2Of effect,had
R6029 T7237 T7236 arg1Of effect,no
R6030 T7237 T7238 arg1Of effect,on
R6031 T7240 T7238 arg2Of expression,on
R6032 T7240 T7239 arg1Of expression,IRF-4
R6033 T7240 T7241 arg1Of expression,(
R6034 T7243 T7241 arg2Of 2D,(
R6035 T7243 T7242 arg1Of 2D,Figure
R6036 T7244 T7241 arg3Of ),(
R6037 T7245 T7246 arg1Of There,was
R6038 T7246 T7249 arg1Of was,in
R6039 T7246 T7256 arg1Of was,","
R6040 T7246 T7257 arg1Of was,as
R6041 T7248 T7246 arg2Of difference,was
R6042 T7248 T7247 arg1Of difference,no
R6043 T7251 T7249 arg2Of effects,in
R6044 T7251 T7250 arg1Of effects,the
R6045 T7251 T7252 arg1Of effects,of
R6046 T7253 T7252 arg2Of AzaC,of
R6047 T7253 T7254 arg1Of AzaC,versus
R6048 T7255 T7254 arg2Of AzadC,versus
R6049 T7258 T7259 arg1Of both,increased
R6050 T7259 T7257 arg2Of increased,as
R6051 T7259 T7267 arg1Of increased,as
R6052 T7263 T7259 arg2Of level,increased
R6053 T7263 T7260 arg1Of level,the
R6054 T7263 T7261 arg1Of level,IRF-4
R6055 T7263 T7262 arg1Of level,mRNA
R6056 T7263 T7264 arg1Of level,in
R6057 T7266 T7264 arg2Of cells,in
R6058 T7266 T7265 arg1Of cells,CML-T1
R6059 T7268 T7267 arg2Of well,as
R6060 T7268 T7269 arg1Of well,(
R6061 T7270 T7269 arg2Of data,(
R6062 T7270 T7272 arg2Of data,shown
R6063 T7272 T7271 arg1Of shown,not
R6064 T7273 T7269 arg3Of ),(
R6065 T7274 T7275 arg1Of This,implied
R6066 T7278 T7277 arg1Of methylation,promoter
R6067 T7278 T7279 arg1Of methylation,may
R6068 T7278 T7280 arg1Of methylation,control
R6069 T7280 T7279 arg2Of control,may
R6070 T7280 T7284 arg1Of control,but
R6071 T7282 T7280 arg2Of expression,control
R6072 T7282 T7281 arg1Of expression,IRF-4
R6073 T7284 T7275 arg2Of but,implied
R6074 T7284 T7276 arg1Of but,that
R6075 T7284 T7283 arg1Of but,","
R6076 T7287 T7285 arg1Of explanation,an
R6077 T7287 T7286 arg1Of explanation,alternative
R6078 T7287 T7288 arg1Of explanation,may
R6079 T7287 T7289 arg1Of explanation,be
R6080 T7289 T7284 arg2Of be,but
R6081 T7289 T7288 arg2Of be,may
R6082 T7289 T7297 arg1Of be,by
R6083 T7290 T7289 arg2Of activation,be
R6084 T7290 T7291 arg1Of activation,of
R6085 T7294 T7291 arg2Of regulators,of
R6086 T7294 T7292 arg1Of regulators,positive
R6087 T7294 T7293 arg1Of regulators,transcriptional
R6088 T7294 T7295 arg1Of regulators,of
R6089 T7296 T7295 arg2Of IRF-4,of
R6090 T7298 T7297 arg2Of AzadC,by
R6091 T7298 T7299 arg1Of AzadC,(
R6092 T7301 T7299 arg2Of AzaC,(
R6093 T7301 T7300 arg1Of AzaC,or
R6094 T7302 T7299 arg3Of ),(
R6497 T7853 T7852 arg1Of enzymes,Methylation-sensitive
R6498 T7853 T7854 arg1Of enzymes,do
R6499 T7853 T7856 arg1Of enzymes,cut
R6500 T7856 T7854 arg2Of cut,do
R6501 T7856 T7855 arg1Of cut,not
R6502 T7858 T7856 arg2Of sites,cut
R6503 T7858 T7857 arg1Of sites,specific
R6504 T7858 T7859 arg1Of sites,in
R6505 T7862 T7859 arg2Of promoter,in
R6506 T7862 T7860 arg1Of promoter,the
R6507 T7862 T7861 arg1Of promoter,IRF-4
R6508 T7862 T7863 arg1Of promoter,in
R6509 T7865 T7863 arg2Of cells,in
R6510 T7865 T7864 arg1Of cells,hematopoietic
R6511 T7868 T7866 arg1Of investigate,To
R6512 T7868 T7867 arg1Of investigate,further
R6513 T7868 T7871 arg1Of investigate,as
R6514 T7870 T7868 arg2Of methylation,investigate
R6515 T7870 T7869 arg1Of methylation,promoter
R6516 T7874 T7871 arg2Of mechanism,as
R6517 T7874 T7872 arg1Of mechanism,a
R6518 T7874 T7873 arg1Of mechanism,regulatory
R6519 T7874 T7875 arg1Of mechanism,of
R6520 T7878 T7875 arg2Of expression,of
R6521 T7878 T7876 arg1Of expression,IRF-4
R6522 T7878 T7877 arg1Of expression,gene
R6523 T7880 T7868 arg1Of restriction-PCR-assays,investigate
R6524 T7880 T7881 arg1Of restriction-PCR-assays,were
R6525 T7880 T7882 arg2Of restriction-PCR-assays,performed
R6526 T7882 T7866 modOf performed,To
R6527 T7882 T7879 arg1Of performed,","
R6528 T7882 T7881 arg2Of performed,were
R6529 T7882 T7883 arg1Of performed,(
R6530 T7882 T7886 arg1Of performed,","
R6531 T7882 T7887 arg1Of performed,where
R6532 T7884 T7883 arg2Of "20,24",(
R6533 T7885 T7883 arg3Of ),(
R6534 T7890 T7888 arg1Of DNA,only
R6535 T7890 T7889 arg2Of DNA,methylated
R6536 T7890 T7891 arg1Of DNA,would
R6537 T7890 T7893 arg1Of DNA,be
R6538 T7890 T7894 arg2Of DNA,cut
R6539 T7890 T7895 arg1Of DNA,enabling
R6540 T7894 T7887 arg2Of cut,where
R6541 T7894 T7891 arg2Of cut,would
R6542 T7894 T7892 arg1Of cut,not
R6543 T7894 T7893 arg2Of cut,be
R6544 T7894 T7895 modOf cut,enabling
R6545 T7898 T7896 arg1Of amplification,subsequent
R6546 T7898 T7897 arg1Of amplification,PCR
R6547 T7898 T7899 arg1Of amplification,and
R6548 T7899 T7895 arg2Of and,enabling
R6549 T7901 T7899 arg2Of versa,and
R6550 T7901 T7900 arg1Of versa,vice
R6551 T7903 T7902 arg1Of DNA,Genomic
R6552 T7903 T7904 arg1Of DNA,from
R6553 T7903 T7918 arg1Of DNA,was
R6554 T7903 T7919 arg2Of DNA,digested
R6555 T7906 T7905 arg1Of cells,leukemic
R6556 T7907 T7908 arg1Of Jurkat,","
R6557 T7908 T7910 arg1Of ",",","
R6558 T7909 T7908 arg2Of CML-T1,","
R6559 T7910 T7912 arg1Of ",",","
R6560 T7911 T7910 arg2Of U-937,","
R6561 T7912 T7914 arg1Of ",",","
R6562 T7913 T7912 arg2Of K-562,","
R6563 T7914 T7906 arg1Of ",",cells
R6564 T7914 T7916 arg1Of ",",and
R6565 T7915 T7914 arg2Of EM-2,","
R6566 T7916 T7904 arg2Of and,from
R6567 T7917 T7916 arg2Of BV-173,and
R6568 T7919 T7918 arg2Of digested,was
R6569 T7919 T7920 arg1Of digested,with
R6570 T7923 T7921 arg1Of enzymes,the
R6571 T7923 T7922 arg1Of enzymes,methylation-sensitive
R6572 T7924 T7925 arg1Of HpaII,","
R6573 T7925 T7927 arg1Of ",",and
R6574 T7926 T7925 arg2Of Bsh1236I,","
R6575 T7927 T7920 arg2Of and,with
R6576 T7927 T7923 arg1Of and,enzymes
R6577 T7929 T7927 arg2Of Bsp143II,and
R6578 T7929 T7928 arg1Of Bsp143II,HaeII-isochizomer
R6579 T7930 T7931 arg1Of EcoRI,","
R6580 T7930 T7932 arg1Of EcoRI,which
R6581 T7930 T7933 arg1Of EcoRI,has
R6582 T7936 T7934 arg1Of site,no
R6583 T7936 T7935 arg1Of site,recognition
R6584 T7936 T7937 arg1Of site,within
R6585 T7936 T7942 arg1Of site,and
R6586 T7940 T7937 arg2Of promoter,within
R6587 T7940 T7938 arg1Of promoter,the
R6588 T7940 T7939 arg1Of promoter,IRF-4
R6589 T7942 T7933 arg2Of and,has
R6590 T7942 T7941 arg1Of and,","
R6591 T7946 T7942 arg2Of MspI,and
R6592 T7946 T7943 arg1Of MspI,the
R6593 T7946 T7944 arg1Of MspI,methylation-resistant
R6594 T7946 T7945 arg1Of MspI,enzyme
R6595 T7946 T7947 arg2Of MspI,served
R6596 T7947 T7948 arg1Of served,as
R6597 T7949 T7948 arg2Of controls,as
R6598 T7953 T7950 arg1Of reactions,Two
R6599 T7953 T7951 arg1Of reactions,separate
R6600 T7953 T7952 arg1Of reactions,amplification
R6601 T7953 T7954 arg1Of reactions,were
R6602 T7953 T7955 arg2Of reactions,performed
R6603 T7955 T7954 arg2Of performed,were
R6604 T7955 T7956 arg1Of performed,","
R6605 T7955 T7957 modOf performed,generating
R6606 T7959 T7957 arg2Of fragments,generating
R6607 T7959 T7958 arg1Of fragments,two
R6608 T7959 T7960 arg1Of fragments,","
R6609 T7961 T7962 arg1Of F1,and
R6610 T7962 T7960 arg2Of and,","
R6611 T7962 T7964 arg1Of and,(
R6612 T7963 T7962 arg2Of F2,and
R6613 T7966 T7964 arg2Of 3A,(
R6614 T7966 T7965 arg1Of 3A,Figure
R6615 T7967 T7964 arg3Of ),(
R6616 T7969 T7968 arg2Of digestion,After
R6617 T7969 T7970 arg1Of digestion,with
R6618 T7971 T7972 arg1Of HpaII,and
R6619 T7972 T7970 arg2Of and,with
R6620 T7973 T7972 arg2Of Bsp143II,and
R6621 T7977 T7974 arg1Of amplification,a
R6622 T7977 T7975 arg1Of amplification,sufficient
R6623 T7977 T7976 arg1Of amplification,PCR
R6624 T7977 T7978 arg1Of amplification,of
R6625 T7977 T7982 arg1Of amplification,was
R6626 T7977 T7983 arg2Of amplification,detected
R6627 T7979 T7980 arg1Of F1,and
R6628 T7980 T7978 arg2Of and,of
R6629 T7981 T7980 arg2Of F2,and
R6630 T7983 T7968 arg1Of detected,After
R6631 T7983 T7982 arg2Of detected,was
R6632 T7983 T7984 arg1Of detected,in
R6633 T7983 T7986 arg1Of detected,from
R6634 T7983 T7998 arg1Of detected,","
R6635 T7983 T7999 modOf detected,suggesting
R6636 T7985 T7984 arg2Of DNA,in
R6637 T7988 T7987 arg1Of Jurkat,IRF-4-negative
R6638 T7988 T7989 arg1Of Jurkat,","
R6639 T7989 T7991 arg1Of ",",","
R6640 T7990 T7989 arg2Of CML-T1,","
R6641 T7991 T7993 arg1Of ",",","
R6642 T7992 T7991 arg2Of U-937,","
R6643 T7993 T7995 arg1Of ",",and
R6644 T7994 T7993 arg2Of K-562,","
R6645 T7995 T7986 arg2Of and,from
R6646 T7997 T7995 arg2Of cells,and
R6647 T7997 T7996 arg1Of cells,EM-2
R6648 T8002 T7999 arg2Of methylation,suggesting
R6649 T8002 T8000 arg1Of methylation,a
R6650 T8002 T8001 arg1Of methylation,promoter
R6651 T8002 T8003 arg1Of methylation,(
R6652 T8002 T8008 arg1Of methylation,at
R6653 T8006 T8003 arg2Of protection,(
R6654 T8006 T8004 arg1Of protection,and
R6655 T8006 T8005 arg1Of protection,restriction
R6656 T8007 T8003 arg3Of ),(
R6657 T8012 T8008 arg2Of sites,at
R6658 T8012 T8009 arg1Of sites,the
R6659 T8012 T8010 arg1Of sites,respective
R6660 T8012 T8011 arg1Of sites,recognition
R6661 T8012 T8013 arg1Of sites,(
R6662 T8015 T8014 arg1Of 3B,Figure
R6663 T8015 T8016 arg1Of 3B,and
R6664 T8016 T8013 arg2Of and,(
R6665 T8017 T8016 arg2Of C,and
R6666 T8018 T8013 arg3Of ),(
R6667 T8024 T8021 arg2Of cells,in
R6668 T8024 T8022 arg1Of cells,IRF-4-positive
R6669 T8024 T8023 arg1Of cells,SD-1
R6670 T8025 T8026 arg1Of digestion,with
R6671 T8025 T8031 arg1Of digestion,inhibited
R6672 T8029 T8026 arg2Of enzymes,with
R6673 T8029 T8027 arg1Of enzymes,the
R6674 T8029 T8028 arg1Of enzymes,methylation-sensitive
R6675 T8031 T8019 arg1Of inhibited,Notably
R6676 T8031 T8020 arg1Of inhibited,","
R6677 T8031 T8021 arg1Of inhibited,in
R6678 T8031 T8030 arg1Of inhibited,completely
R6679 T8032 T8031 arg2Of amplification,inhibited
R6680 T8032 T8033 arg1Of amplification,of
R6681 T8034 T8035 arg1Of F1,and
R6682 T8035 T8033 arg2Of and,of
R6683 T8036 T8035 arg2Of F2,and
R6684 T8040 T8037 arg2Of cells,In
R6685 T8040 T8038 arg1Of cells,IRF-4-positive
R6686 T8040 T8039 arg1Of cells,BV-173
R6687 T8042 T8041 arg1Of HpaII,a
R6688 T8042 T8044 arg1Of HpaII,but
R6689 T8044 T8043 arg1Of but,","
R6690 T8044 T8045 arg1Of but,not
R6691 T8044 T8051 arg1Of but,reduced
R6692 T8048 T8044 arg2Of digestion,but
R6693 T8048 T8046 arg1Of digestion,a
R6694 T8048 T8047 arg1Of digestion,Bsh1236I
R6695 T8051 T8049 arg1Of reduced,","
R6696 T8051 T8050 arg1Of reduced,significantly
R6697 T8051 T8063 arg1Of reduced,whereas
R6698 T8055 T8051 arg2Of message,reduced
R6699 T8055 T8052 arg1Of message,the
R6700 T8055 T8053 arg1Of message,amplifiable
R6701 T8055 T8054 arg1Of message,DNA
R6702 T8055 T8056 arg1Of message,of
R6703 T8057 T8056 arg2Of F2,of
R6704 T8057 T8058 arg1Of F2,(
R6705 T8060 T8058 arg2Of 3C,(
R6706 T8060 T8059 arg1Of 3C,Figure
R6707 T8061 T8058 arg3Of ),(
R6708 T8063 T8037 arg1Of whereas,In
R6709 T8063 T8062 arg1Of whereas,","
R6710 T8064 T8065 arg1Of amplification,of
R6711 T8064 T8067 arg1Of amplification,was
R6712 T8064 T8069 arg2Of amplification,affected
R6713 T8066 T8065 arg2Of F1,of
R6714 T8069 T8063 arg2Of affected,whereas
R6715 T8069 T8067 arg2Of affected,was
R6716 T8069 T8068 arg1Of affected,not
R6717 T8069 T8070 arg1Of affected,(
R6718 T8072 T8070 arg2Of 3B,(
R6719 T8072 T8071 arg1Of 3B,Figure
R6720 T8073 T8070 arg3Of ),(
R6721 T8074 T8075 arg1Of This,implied
R6722 T8078 T8077 arg1Of transcription,IRF-4
R6723 T8078 T8079 arg1Of transcription,in
R6724 T8078 T8084 arg1Of transcription,is
R6725 T8078 T8085 arg2Of transcription,associated
R6726 T8080 T8081 arg1Of SD-1,and
R6727 T8082 T8081 arg2Of BV-173,and
R6728 T8083 T8079 arg2Of cells,in
R6729 T8083 T8080 arg1Of cells,SD-1
R6730 T8083 T8082 arg1Of cells,BV-173
R6731 T8085 T8075 arg2Of associated,implied
R6732 T8085 T8076 arg1Of associated,that
R6733 T8085 T8084 arg2Of associated,is
R6734 T8085 T8086 arg1Of associated,with
R6735 T8085 T8090 arg1Of associated,(
R6736 T8085 T8098 arg1Of associated,as
R6737 T8089 T8086 arg2Of methylation,with
R6738 T8089 T8087 arg1Of methylation,less
R6739 T8089 T8088 arg1Of methylation,promoter
R6740 T8091 T8090 arg2Of in,(
R6741 T8092 T8091 arg2Of BV-173,in
R6742 T8092 T8094 arg1Of BV-173,at
R6743 T8094 T8093 arg1Of at,especially
R6744 T8096 T8094 arg2Of sites,at
R6745 T8096 T8095 arg1Of sites,HpaII
R6746 T8097 T8090 arg3Of ),(
R6747 T8099 T8098 arg2Of compared,as
R6748 T8099 T8100 arg1Of compared,with
R6749 T8104 T8100 arg2Of cells,with
R6750 T8104 T8101 arg1Of cells,the
R6751 T8104 T8102 arg2Of cells,tested
R6752 T8104 T8103 arg1Of cells,IRF-4-negative
R7082 T8580 T8578 arg1Of sites,Specific
R7083 T8580 T8579 arg1Of sites,CpG
R7084 T8580 T8581 arg1Of sites,in
R7085 T8580 T8585 arg1Of sites,are
R7086 T8580 T8586 arg2Of sites,methylated
R7087 T8584 T8581 arg2Of promoter,in
R7088 T8584 T8582 arg1Of promoter,the
R7089 T8584 T8583 arg1Of promoter,IRF-4
R7090 T8586 T8585 arg2Of methylated,are
R7091 T8586 T8587 arg1Of methylated,in
R7092 T8589 T8587 arg2Of cells,in
R7093 T8589 T8588 arg1Of cells,hematopoietic
R7094 T8591 T8590 arg2Of order,In
R7095 T8594 T8590 arg3Of map,In
R7096 T8594 T8592 arg1Of map,to
R7097 T8594 T8593 arg1Of map,exactly
R7098 T8597 T8594 arg2Of sites,map
R7099 T8597 T8595 arg1Of sites,the
R7100 T8597 T8596 arg1Of sites,methylation
R7101 T8597 T8598 arg1Of sites,within
R7102 T8601 T8598 arg2Of promoter,within
R7103 T8601 T8599 arg1Of promoter,the
R7104 T8601 T8600 arg1Of promoter,IRF-4
R7105 T8603 T8594 arg1Of we,map
R7106 T8603 T8604 arg1Of we,treated
R7107 T8604 T8590 arg1Of treated,In
R7108 T8604 T8602 arg1Of treated,","
R7109 T8604 T8638 arg1Of treated,","
R7110 T8604 T8639 arg1Of treated,whereas
R7111 T8605 T8604 arg2Of DNA,treated
R7112 T8605 T8606 arg1Of DNA,of
R7113 T8605 T8620 arg1Of DNA,of
R7114 T8606 T8619 arg1Of of,as
R7115 T8607 T8608 arg1Of Jurkat,","
R7116 T8608 T8610 arg1Of ",",","
R7117 T8609 T8608 arg2Of CML-T1,","
R7118 T8610 T8612 arg1Of ",",","
R7119 T8611 T8610 arg2Of U-937,","
R7120 T8612 T8614 arg1Of ",",and
R7121 T8613 T8612 arg2Of K-562,","
R7122 T8615 T8614 arg2Of EM-2,and
R7123 T8616 T8606 arg2Of cells,of
R7124 T8616 T8607 arg1Of cells,Jurkat
R7125 T8616 T8609 arg1Of cells,CML-T1
R7126 T8616 T8611 arg1Of cells,U-937
R7127 T8616 T8613 arg1Of cells,K-562
R7128 T8616 T8615 arg1Of cells,EM-2
R7129 T8619 T8617 arg1Of as,as
R7130 T8619 T8618 arg1Of as,well
R7131 T8620 T8619 arg2Of of,as
R7132 T8621 T8622 arg1Of SD-1,","
R7133 T8622 T8624 arg1Of ",",and
R7134 T8623 T8622 arg2Of RPMI-8226,","
R7135 T8624 T8620 arg2Of and,of
R7136 T8624 T8628 arg1Of and,with
R7137 T8624 T8630 arg1Of and,","
R7138 T8624 T8631 arg1Of and,which
R7139 T8624 T8633 arg1Of and,converts
R7140 T8627 T8624 arg2Of cells,and
R7141 T8627 T8625 arg1Of cells,BV-173
R7142 T8627 T8626 arg1Of cells,control
R7143 T8629 T8628 arg2Of bisulfite,with
R7144 T8633 T8632 arg1Of converts,chemically
R7145 T8633 T8636 arg1Of converts,to
R7146 T8635 T8633 arg2Of cytosine,converts
R7147 T8635 T8634 arg1Of cytosine,unmethylated
R7148 T8637 T8636 arg2Of uracil,to
R7149 T8640 T8641 arg1Of it,has
R7150 T8641 T8639 arg2Of has,whereas
R7151 T8641 T8644 arg1Of has,on
R7152 T8641 T8647 arg1Of has,","
R7153 T8641 T8648 arg1Of has,i.e.
R7154 T8641 T8649 arg1Of has,in
R7155 T8643 T8641 arg2Of effect,has
R7156 T8643 T8642 arg1Of effect,no
R7157 T8646 T8644 arg2Of cytosine,on
R7158 T8646 T8645 arg2Of cytosine,methylated
R7159 T8650 T8649 arg2Of CpG,in
R7160 T8650 T8651 arg1Of CpG,(
R7161 T8652 T8651 arg2Of 34,(
R7162 T8653 T8651 arg3Of ),(
R7163 T8655 T8654 arg1Of technique,This
R7164 T8655 T8656 arg1Of technique,is
R7165 T8655 T8658 arg1Of technique,useful
R7166 T8658 T8656 arg2Of useful,is
R7167 T8658 T8657 arg1Of useful,especially
R7168 T8658 T8659 arg1Of useful,for
R7169 T8660 T8659 arg2Of detection,for
R7170 T8660 T8661 arg1Of detection,of
R7171 T8664 T8661 arg2Of patterns,of
R7172 T8664 T8662 arg1Of patterns,unknown
R7173 T8664 T8663 arg1Of patterns,methylation
R7174 T8666 T8665 arg1Of amplification,PCR
R7175 T8666 T8667 arg1Of amplification,","
R7176 T8667 T8669 arg1Of ",",and
R7177 T8668 T8667 arg2Of cloning,","
R7178 T8669 T8671 arg1Of and,of
R7179 T8669 T8675 arg1Of and,showed
R7180 T8670 T8669 arg2Of sequencing,and
R7181 T8674 T8671 arg2Of DNA,of
R7182 T8674 T8672 arg1Of DNA,the
R7183 T8674 T8673 arg1Of DNA,bisulfite-treated
R7184 T8679 T8675 arg2Of pattern,showed
R7185 T8679 T8676 arg1Of pattern,a
R7186 T8679 T8677 arg1Of pattern,specific
R7187 T8679 T8678 arg1Of pattern,methylation
R7188 T8679 T8680 arg1Of pattern,of
R7189 T8679 T8686 arg1Of pattern,in
R7190 T8685 T8680 arg2Of sites,of
R7191 T8685 T8681 arg1Of sites,the
R7192 T8685 T8682 arg2Of sites,analyzed
R7193 T8685 T8683 arg1Of sites,62
R7194 T8685 T8684 arg1Of sites,CpG
R7195 T8689 T8686 arg2Of lines,in
R7196 T8689 T8687 arg1Of lines,all
R7197 T8689 T8688 arg1Of lines,cell
R7198 T8689 T8690 arg1Of lines,(
R7199 T8691 T8692 arg1Of Figure,4
R7200 T8691 T8693 arg1Of Figure,and
R7201 T8693 T8690 arg2Of and,(
R7202 T8694 T8693 arg2Of Table,and
R7203 T8694 T8695 arg1Of Table,1
R7204 T8696 T8690 arg3Of ),(
R7205 T8698 T8697 arg2Of general,In
R7206 T8702 T8700 arg1Of status,the
R7207 T8702 T8701 arg1Of status,methylational
R7208 T8702 T8703 arg1Of status,ranged
R7209 T8703 T8697 arg1Of ranged,In
R7210 T8703 T8699 arg1Of ranged,","
R7211 T8703 T8704 arg1Of ranged,from
R7212 T8707 T8704 arg2Of line,from
R7213 T8707 T8705 arg1Of line,one
R7214 T8707 T8706 arg1Of line,cell
R7215 T8707 T8708 arg1Of line,with
R7216 T8711 T8710 arg1Of non-methylated,nearly
R7217 T8713 T8708 arg2Of promoter,with
R7218 T8713 T8709 arg1Of promoter,a
R7219 T8713 T8711 arg1Of promoter,non-methylated
R7220 T8713 T8712 arg1Of promoter,IRF-4
R7221 T8713 T8714 arg1Of promoter,(
R7222 T8713 T8719 arg1Of promoter,to
R7223 T8715 T8714 arg2Of SD-1,(
R7224 T8715 T8716 arg1Of SD-1,","
R7225 T8717 T8716 arg2Of IRF-4-positive,","
R7226 T8718 T8714 arg3Of ),(
R7227 T8722 T8721 arg1Of methylated,completely
R7228 T8724 T8719 arg2Of promoter,to
R7229 T8724 T8720 arg1Of promoter,a
R7230 T8724 T8722 arg1Of promoter,methylated
R7231 T8724 T8723 arg1Of promoter,IRF-4
R7232 T8724 T8725 arg1Of promoter,in
R7233 T8726 T8725 arg2Of CML-T1,in
R7234 T8726 T8727 arg1Of CML-T1,(
R7235 T8728 T8727 arg2Of IRF-4-negative,(
R7236 T8729 T8727 arg3Of ),(
R7237 T8733 T8732 arg1Of percentage,the
R7238 T8733 T8734 arg1Of percentage,of
R7239 T8733 T8737 arg1Of percentage,in
R7240 T8733 T8744 arg1Of percentage,was
R7241 T8733 T8746 arg1Of percentage,low
R7242 T8736 T8734 arg2Of methylation,of
R7243 T8736 T8735 arg1Of methylation,CpG
R7244 T8740 T8737 arg2Of promoter,in
R7245 T8740 T8738 arg1Of promoter,the
R7246 T8740 T8739 arg1Of promoter,IRF-4
R7247 T8740 T8741 arg1Of promoter,from
R7248 T8743 T8741 arg2Of cells,from
R7249 T8743 T8742 arg1Of cells,IRF-4-positive
R7250 T8744 T8730 arg1Of was,Interestingly
R7251 T8744 T8731 arg1Of was,","
R7252 T8746 T8744 arg2Of low,was
R7253 T8746 T8745 arg1Of low,very
R7254 T8746 T8747 arg1Of low,(
R7255 T8750 T8747 arg2Of %,(
R7256 T8750 T8748 arg1Of %,mean
R7257 T8750 T8749 arg1Of %,24
R7258 T8751 T8747 arg3Of ),(
R7259 T8752 T8744 arg3Of as,was
R7260 T8753 T8752 arg2Of compared,as
R7261 T8753 T8754 arg1Of compared,with
R7262 T8756 T8754 arg2Of cells,with
R7263 T8756 T8755 arg1Of cells,IRF-4-negative
R7264 T8756 T8757 arg1Of cells,(
R7265 T8756 T8762 arg1Of cells,(
R7266 T8760 T8757 arg2Of %,(
R7267 T8760 T8758 arg1Of %,mean
R7268 T8760 T8759 arg1Of %,94
R7269 T8761 T8757 arg3Of ),(
R7270 T8764 T8763 arg1Of 4A,Figure
R7271 T8764 T8765 arg1Of 4A,and
R7272 T8765 T8762 arg2Of and,(
R7273 T8767 T8765 arg2Of 1,and
R7274 T8767 T8766 arg1Of 1,Table
R7275 T8768 T8762 arg3Of ),(
R7276 T8770 T8769 arg1Of 5′-region,A
R7277 T8770 T8771 arg1Of 5′-region,(
R7278 T8770 T8774 arg1Of 5′-region,with
R7279 T8770 T8794 arg1Of 5′-region,was
R7280 T8770 T8795 arg2Of 5′-region,found
R7281 T8772 T8771 arg2Of R1,(
R7282 T8773 T8771 arg3Of ),(
R7283 T8778 T8774 arg2Of sites,with
R7284 T8778 T8775 arg1Of sites,13
R7285 T8778 T8776 arg2Of sites,hypermethylated
R7286 T8778 T8777 arg1Of sites,CpG
R7287 T8778 T8779 arg1Of sites,(
R7288 T8781 T8779 arg2Of number,(
R7289 T8781 T8780 arg1Of number,mean
R7290 T8781 T8782 arg1Of number,of
R7291 T8781 T8785 arg1Of number,5.5
R7292 T8784 T8782 arg2Of clones,of
R7293 T8784 T8783 arg2Of clones,methylated
R7294 T8785 T8786 arg1Of 5.5,of
R7295 T8785 T8788 arg1Of 5.5,with
R7296 T8787 T8786 arg2Of 8,of
R7297 T8789 T8790 arg1Of 77,%
R7298 T8792 T8788 arg2Of CpGs,with
R7299 T8792 T8789 arg1Of CpGs,77
R7300 T8792 T8791 arg2Of CpGs,methylated
R7301 T8793 T8779 arg3Of ),(
R7302 T8795 T8794 arg2Of found,was
R7303 T8795 T8796 arg1Of found,in
R7304 T8795 T8799 arg1Of found,(
R7305 T8795 T8805 arg1Of found,and
R7306 T8798 T8796 arg2Of cells,in
R7307 T8798 T8797 arg1Of cells,most
R7308 T8800 T8799 arg2Of except,(
R7309 T8801 T8802 arg1Of SD-1,and
R7310 T8802 T8800 arg2Of and,except
R7311 T8803 T8802 arg2Of RPMI-8226,and
R7312 T8804 T8799 arg3Of ),(
R7313 T8807 T8806 arg1Of 3′-region,a
R7314 T8807 T8808 arg1Of 3′-region,(
R7315 T8807 T8811 arg1Of 3′-region,of
R7316 T8807 T8831 arg1Of 3′-region,was
R7317 T8807 T8832 arg2Of 3′-region,found
R7318 T8809 T8808 arg2Of R3,(
R7319 T8810 T8808 arg3Of ),(
R7320 T8815 T8811 arg2Of sites,of
R7321 T8815 T8812 arg1Of sites,6
R7322 T8815 T8813 arg2Of sites,hypomethylated
R7323 T8815 T8814 arg1Of sites,CpG
R7324 T8815 T8816 arg1Of sites,(
R7325 T8818 T8816 arg2Of number,(
R7326 T8818 T8817 arg1Of number,mean
R7327 T8818 T8819 arg1Of number,of
R7328 T8818 T8822 arg1Of number,1.7
R7329 T8821 T8819 arg2Of clones,of
R7330 T8821 T8820 arg2Of clones,methylated
R7331 T8822 T8823 arg1Of 1.7,of
R7332 T8822 T8825 arg1Of 1.7,with
R7333 T8824 T8823 arg2Of 8,of
R7334 T8826 T8827 arg1Of 33,%
R7335 T8829 T8825 arg2Of CpGs,with
R7336 T8829 T8826 arg1Of CpGs,33
R7337 T8829 T8828 arg2Of CpGs,methylated
R7338 T8830 T8816 arg3Of ),(
R7339 T8832 T8805 arg2Of found,and
R7340 T8832 T8831 arg2Of found,was
R7341 T8832 T8833 arg1Of found,in
R7342 T8835 T8833 arg2Of cells,in
R7343 T8835 T8834 arg1Of cells,most
R7344 T8835 T8836 arg1Of cells,(
R7345 T8835 T8842 arg1Of cells,(
R7346 T8837 T8836 arg2Of except,(
R7347 T8838 T8839 arg1Of CML-T1,and
R7348 T8839 T8837 arg2Of and,except
R7349 T8840 T8839 arg2Of U-937,and
R7350 T8841 T8836 arg3Of ),(
R7351 T8844 T8843 arg1Of 4A,Figure
R7352 T8844 T8845 arg1Of 4A,and
R7353 T8845 T8842 arg2Of and,(
R7354 T8847 T8845 arg2Of 1,and
R7355 T8847 T8846 arg1Of 1,Table
R7356 T8848 T8842 arg3Of ),(
R7357 T8852 T8851 arg1Of stretch,a
R7358 T8852 T8853 arg1Of stretch,of
R7359 T8852 T8863 arg1Of stretch,was
R7360 T8852 T8864 arg2Of stretch,detected
R7361 T8856 T8853 arg2Of sites,of
R7362 T8856 T8854 arg1Of sites,13
R7363 T8856 T8855 arg1Of sites,CpG
R7364 T8856 T8857 arg1Of sites,(
R7365 T8859 T8857 arg2Of 10–22,(
R7366 T8859 T8858 arg1Of 10–22,#
R7367 T8859 T8860 arg1Of 10–22,;
R7368 T8861 T8860 arg2Of R2,;
R7369 T8862 T8857 arg3Of ),(
R7370 T8864 T8849 arg1Of detected,Intriguingly
R7371 T8864 T8850 arg1Of detected,","
R7372 T8864 T8863 arg2Of detected,was
R7373 T8864 T8865 arg1Of detected,in
R7374 T8864 T8866 arg1Of detected,between
R7375 T8868 T8866 arg2Of regions,between
R7376 T8868 T8867 arg1Of regions,these
R7377 T8868 T8869 arg1Of regions,","
R7378 T8868 T8870 arg1Of regions,which
R7379 T8868 T8871 arg1Of regions,were
R7380 T8868 T8873 arg2Of regions,methylated
R7381 T8868 T8893 arg1Of regions,non-methylated
R7382 T8873 T8872 arg1Of methylated,highly
R7383 T8873 T8874 arg1Of methylated,in
R7384 T8873 T8891 arg1Of methylated,but
R7385 T8875 T8874 arg2Of IRF-4-negative,in
R7386 T8875 T8876 arg1Of IRF-4-negative,(
R7387 T8878 T8876 arg2Of number,(
R7388 T8878 T8877 arg1Of number,mean
R7389 T8878 T8879 arg1Of number,of
R7390 T8878 T8882 arg1Of number,7.1
R7391 T8881 T8879 arg2Of clones,of
R7392 T8881 T8880 arg2Of clones,methylated
R7393 T8882 T8883 arg1Of 7.1,of
R7394 T8882 T8885 arg1Of 7.1,with
R7395 T8884 T8883 arg2Of 8,of
R7396 T8886 T8887 arg1Of 89,%
R7397 T8889 T8885 arg2Of CpGs,with
R7398 T8889 T8886 arg1Of CpGs,89
R7399 T8889 T8888 arg2Of CpGs,methylated
R7400 T8890 T8876 arg3Of ),(
R7401 T8891 T8871 arg2Of but,were
R7402 T8893 T8891 arg2Of non-methylated,but
R7403 T8893 T8892 arg1Of non-methylated,totally
R7404 T8893 T8894 arg1Of non-methylated,in
R7405 T8896 T8894 arg2Of cells,in
R7406 T8896 T8895 arg1Of cells,IRF-4-positive
R7407 T8896 T8897 arg1Of cells,(
R7408 T8899 T8898 arg1Of 4A,Figure
R7409 T8899 T8900 arg1Of 4A,and
R7410 T8900 T8897 arg2Of and,(
R7411 T8901 T8900 arg2Of B,and
R7412 T8902 T8897 arg3Of ),(
R7413 T8907 T8905 arg1Of sites,three
R7414 T8907 T8906 arg1Of sites,CpG
R7415 T8907 T8908 arg1Of sites,at
R7416 T8907 T8912 arg1Of sites,(
R7417 T8907 T8920 arg1Of sites,and
R7418 T8911 T8908 arg2Of end,at
R7419 T8911 T8909 arg1Of end,the
R7420 T8911 T8910 arg1Of end,5′
R7421 T8914 T8915 arg1Of 54,","
R7422 T8915 T8912 arg2Of ",",(
R7423 T8915 T8913 arg1Of ",",#
R7424 T8915 T8917 arg1Of ",",","
R7425 T8916 T8915 arg2Of 56,","
R7426 T8918 T8917 arg2Of 58,","
R7427 T8919 T8912 arg3Of ),(
R7428 T8920 T8924 arg1Of and,at
R7429 T8920 T8928 arg1Of and,(
R7430 T8920 T8934 arg1Of and,showed
R7431 T8923 T8920 arg2Of motifs,and
R7432 T8923 T8921 arg1Of motifs,two
R7433 T8923 T8922 arg1Of motifs,CpG
R7434 T8927 T8924 arg2Of end,at
R7435 T8927 T8925 arg1Of end,the
R7436 T8927 T8926 arg1Of end,3′
R7437 T8930 T8928 arg2Of 1,(
R7438 T8930 T8929 arg1Of 1,#
R7439 T8930 T8931 arg1Of 1,","
R7440 T8932 T8931 arg2Of 2,","
R7441 T8933 T8928 arg3Of ),(
R7442 T8934 T8903 arg1Of showed,Furthermore
R7443 T8934 T8904 arg1Of showed,","
R7444 T8937 T8934 arg2Of correlation,showed
R7445 T8937 T8935 arg1Of correlation,this
R7446 T8937 T8936 arg1Of correlation,direct
R7447 T8937 T8938 arg1Of correlation,between
R7448 T8941 T8939 arg1Of status,high
R7449 T8941 T8940 arg1Of status,methylation
R7450 T8941 T8942 arg1Of status,and
R7451 T8942 T8938 arg2Of and,between
R7452 T8943 T8942 arg2Of absence,and
R7453 T8943 T8944 arg1Of absence,of
R7454 T8946 T8944 arg2Of expression,of
R7455 T8946 T8945 arg1Of expression,IRF-4
R7456 T8948 T8947 arg2Of addition,In
R7457 T8952 T8950 arg1Of sites,two
R7458 T8952 T8951 arg1Of sites,CpG
R7459 T8952 T8953 arg1Of sites,located
R7460 T8952 T8969 arg1Of sites,are
R7461 T8952 T8971 arg1Of sites,methylated
R7462 T8953 T8954 arg1Of located,in
R7463 T8956 T8955 arg1Of NFκB,a
R7464 T8956 T8957 arg1Of NFκB,(
R7465 T8956 T8961 arg1Of NFκB,and
R7466 T8959 T8957 arg2Of 48,(
R7467 T8959 T8958 arg1Of 48,#
R7468 T8960 T8957 arg3Of ),(
R7469 T8961 T8954 arg2Of and,in
R7470 T8964 T8961 arg2Of element,and
R7471 T8964 T8962 arg1Of element,a
R7472 T8964 T8963 arg1Of element,SP1
R7473 T8964 T8965 arg1Of element,(
R7474 T8967 T8965 arg2Of 45,(
R7475 T8967 T8966 arg1Of 45,#
R7476 T8968 T8965 arg3Of ),(
R7477 T8969 T8947 arg1Of are,In
R7478 T8969 T8949 arg1Of are,","
R7479 T8971 T8969 arg2Of methylated,are
R7480 T8971 T8970 arg1Of methylated,less
R7481 T8971 T8972 arg1Of methylated,in
R7482 T8971 T8974 arg1Of methylated,than
R7483 T8973 T8972 arg2Of IRF-4-positive,in
R7484 T8975 T8974 arg2Of in,than
R7485 T8980 T8975 arg2Of number,in
R7486 T8980 T8976 arg1Of number,IRF-4-negative
R7487 T8980 T8977 arg1Of number,cells
R7488 T8980 T8978 arg1Of number,(
R7489 T8980 T8979 arg1Of number,mean
R7490 T8980 T8981 arg1Of number,of
R7491 T8983 T8981 arg2Of clones,of
R7492 T8983 T8982 arg2Of clones,methylated
R7493 T8983 T8984 arg1Of clones,:
R7494 T8985 T8986 arg1Of 1/8,versus
R7495 T8986 T8988 arg1Of versus,)
R7496 T8987 T8986 arg2Of 8/8,versus
R7497 T8990 T8989 arg1Of results,These
R7498 T8990 T8991 arg1Of results,indicate
R7499 T8993 T8991 arg2Of involvement,indicate
R7500 T8993 T8992 arg1Of involvement,the
R7501 T8993 T8994 arg1Of involvement,of
R7502 T8993 T8997 arg1Of involvement,in
R7503 T8996 T8994 arg2Of methylation,of
R7504 T8996 T8995 arg1Of methylation,CpG
R7505 T8999 T8997 arg2Of regulation,in
R7506 T8999 T8998 arg1Of regulation,the
R7507 T8999 T9000 arg1Of regulation,of
R7508 T9002 T9000 arg2Of expression,of
R7509 T9002 T9001 arg1Of expression,IRF-4
R7510 T9002 T9003 arg1Of expression,in
R7511 T9005 T9003 arg2Of cells,in
R7512 T9005 T9004 arg1Of cells,leukemic
R8042 T9707 T9706 arg1Of vitro,In
R8043 T9708 T9707 arg1Of methylation,vitro
R8044 T9708 T9709 arg1Of methylation,of
R8045 T9708 T9714 arg1Of methylation,decreases
R8046 T9713 T9709 arg2Of construct,of
R8047 T9713 T9710 arg1Of construct,an
R8048 T9713 T9711 arg1Of construct,IRF-4
R8049 T9713 T9712 arg1Of construct,promoter-reporter
R8050 T9716 T9714 arg2Of activity,decreases
R8051 T9716 T9715 arg1Of activity,its
R8052 T9718 T9717 arg1Of provide,To
R8053 T9719 T9718 arg2Of evidence,provide
R8054 T9719 T9720 arg1Of evidence,for
R8055 T9723 T9720 arg2Of effect,for
R8056 T9723 T9721 arg1Of effect,a
R8057 T9723 T9722 arg1Of effect,direct
R8058 T9723 T9724 arg1Of effect,of
R8059 T9723 T9727 arg1Of effect,on
R8060 T9726 T9724 arg2Of status,of
R8061 T9726 T9725 arg1Of status,methylational
R8062 T9730 T9727 arg2Of activity,on
R8063 T9730 T9728 arg1Of activity,IRF-4
R8064 T9730 T9729 arg1Of activity,promoter
R8065 T9731 T9718 arg1Of we,provide
R8066 T9731 T9732 arg1Of we,performed
R8067 T9732 T9717 modOf performed,To
R8068 T9732 T9740 arg1Of performed,before
R8069 T9732 T9742 arg1Of performed,after
R8070 T9735 T9732 arg2Of assays,performed
R8071 T9735 T9733 arg1Of assays,reporter
R8072 T9735 T9734 arg1Of assays,gene
R8073 T9735 T9736 arg1Of assays,with
R8074 T9739 T9736 arg2Of constructs,with
R8075 T9739 T9737 arg1Of constructs,IRF-4
R8076 T9739 T9738 arg1Of constructs,promoter
R8077 T9740 T9741 arg1Of before,and
R8078 T9742 T9741 arg2Of after,and
R8079 T9745 T9744 arg1Of vitro,in
R8080 T9746 T9740 arg2Of methylation,before
R8081 T9746 T9742 arg2Of methylation,after
R8082 T9746 T9743 arg1Of methylation,their
R8083 T9746 T9745 arg1Of methylation,vitro
R8084 T9749 T9747 arg1Of methylation,A
R8085 T9749 T9748 arg1Of methylation,complete
R8086 T9749 T9750 arg1Of methylation,of
R8087 T9749 T9753 arg1Of methylation,was
R8088 T9749 T9754 arg2Of methylation,checked
R8089 T9752 T9750 arg2Of constructs,of
R8090 T9752 T9751 arg1Of constructs,these
R8091 T9754 T9753 arg2Of checked,was
R8092 T9754 T9755 arg1Of checked,via
R8093 T9757 T9755 arg2Of assays,via
R8094 T9757 T9756 arg1Of assays,restriction
R8095 T9757 T9758 arg1Of assays,with
R8096 T9760 T9758 arg2Of endonucleases,with
R8097 T9760 T9759 arg1Of endonucleases,methylation-sensitive
R8098 T9760 T9761 arg1Of endonucleases,(
R8099 T9763 T9761 arg2Of 5A,(
R8100 T9763 T9762 arg1Of 5A,Figure
R8101 T9764 T9761 arg3Of ),(
R8102 T9767 T9768 arg1Of methylation,of
R8103 T9767 T9773 arg1Of methylation,decreased
R8104 T9771 T9768 arg2Of promoter,of
R8105 T9771 T9769 arg1Of promoter,the
R8106 T9771 T9770 arg1Of promoter,IRF-4
R8107 T9773 T9765 arg1Of decreased,Intriguingly
R8108 T9773 T9766 arg1Of decreased,","
R8109 T9773 T9772 arg1Of decreased,significantly
R8110 T9773 T9780 arg1Of decreased,by
R8111 T9775 T9773 arg2Of activity,decreased
R8112 T9775 T9774 arg1Of activity,promoter
R8113 T9775 T9776 arg1Of activity,in
R8114 T9779 T9776 arg2Of cells,in
R8115 T9779 T9777 arg1Of cells,IRF-4-positive
R8116 T9779 T9778 arg1Of cells,SD-1
R8117 T9782 T9780 arg2Of %,by
R8118 T9782 T9781 arg1Of %,85.0
R8119 T9782 T9783 arg1Of %,(
R8120 T9785 T9783 arg2Of 5B,(
R8121 T9785 T9784 arg1Of 5B,Figure
R8122 T9786 T9783 arg3Of ),(
R8123 T9789 T9787 arg1Of effect,The
R8124 T9789 T9788 arg1Of effect,silencing
R8125 T9789 T9790 arg1Of effect,of
R8126 T9789 T9793 arg1Of effect,was
R8127 T9789 T9795 arg1Of effect,restricted
R8128 T9792 T9790 arg2Of methylation,of
R8129 T9792 T9791 arg1Of methylation,CpG
R8130 T9793 T9794 arg1Of was,not
R8131 T9793 T9799 arg1Of was,","
R8132 T9793 T9800 arg1Of was,since
R8133 T9795 T9793 arg2Of restricted,was
R8134 T9795 T9796 arg1Of restricted,to
R8135 T9798 T9796 arg2Of cells,to
R8136 T9798 T9797 arg1Of cells,IRF-4-positive
R8137 T9802 T9801 arg1Of vitro,in
R8138 T9803 T9802 arg1Of methylation,vitro
R8139 T9803 T9804 arg1Of methylation,led
R8140 T9804 T9800 arg2Of led,since
R8141 T9804 T9805 arg1Of led,to
R8142 T9807 T9808 arg1Of 92.9,%
R8143 T9809 T9805 arg2Of abrogation,to
R8144 T9809 T9806 arg1Of abrogation,a
R8145 T9809 T9807 arg1Of abrogation,92.9
R8146 T9809 T9810 arg1Of abrogation,of
R8147 T9809 T9813 arg1Of abrogation,in
R8148 T9812 T9810 arg2Of activity,of
R8149 T9812 T9811 arg1Of activity,promoter
R8150 T9816 T9813 arg2Of cells,in
R8151 T9816 T9814 arg1Of cells,IRF-4-negative
R8152 T9816 T9815 arg1Of cells,Jurkat
R8153 T9816 T9817 arg1Of cells,(
R8154 T9819 T9817 arg2Of 5C,(
R8155 T9819 T9818 arg1Of 5C,Figure
R8156 T9820 T9817 arg3Of ),(
R8157 T9822 T9821 arg2Of contrast,In
R8158 T9825 T9824 arg1Of methylation,control
R8159 T9825 T9826 arg1Of methylation,of
R8160 T9825 T9830 arg1Of methylation,with
R8161 T9825 T9843 arg1Of methylation,had
R8162 T9829 T9826 arg2Of construct,of
R8163 T9829 T9827 arg1Of construct,a
R8164 T9829 T9828 arg1Of construct,reporter
R8165 T9833 T9831 arg1Of promoter,a
R8166 T9833 T9832 arg1Of promoter,different
R8167 T9833 T9834 arg1Of promoter,(
R8168 T9833 T9839 arg1Of promoter,as
R8169 T9835 T9834 arg2Of FasL,(
R8170 T9836 T9834 arg3Of ),(
R8171 T9839 T9830 arg2Of as,with
R8172 T9839 T9837 arg1Of as,as
R8173 T9839 T9838 arg1Of as,well
R8174 T9842 T9839 arg2Of vector,as
R8175 T9842 T9840 arg1Of vector,an
R8176 T9842 T9841 arg1Of vector,empty
R8177 T9843 T9821 arg1Of had,In
R8178 T9843 T9823 arg1Of had,","
R8179 T9845 T9843 arg2Of effect,had
R8180 T9845 T9844 arg1Of effect,no
R8181 T9845 T9846 arg1Of effect,on
R8182 T9849 T9846 arg2Of activity,on
R8183 T9849 T9847 arg1Of activity,the
R8184 T9849 T9848 arg1Of activity,reporter
R8185 T9849 T9850 arg1Of activity,(
R8186 T9851 T9850 arg2Of data,(
R8187 T9851 T9853 arg2Of data,shown
R8188 T9853 T9852 arg1Of shown,not
R8189 T9854 T9850 arg3Of ),(
R8190 T9856 T9855 arg1Of data,These
R8191 T9856 T9857 arg1Of data,proved
R8192 T9860 T9857 arg2Of association,proved
R8193 T9860 T9858 arg1Of association,a
R8194 T9860 T9859 arg1Of association,direct
R8195 T9860 T9861 arg1Of association,between
R8196 T9862 T9863 arg1Of methylation,and
R8197 T9863 T9861 arg2Of and,between
R8198 T9863 T9865 arg1Of and,of
R8199 T9864 T9863 arg2Of activity,and
R8200 T9868 T9865 arg2Of promoter,of
R8201 T9868 T9866 arg1Of promoter,the
R8202 T9868 T9867 arg1Of promoter,IRF-4
R8480 T10257 T10256 arg1Of expression,mRNA
R8481 T10257 T10258 arg1Of expression,of
R8482 T10257 T10264 arg1Of expression,may
R8483 T10257 T10266 arg1Of expression,be
R8484 T10257 T10267 arg2Of expression,associated
R8485 T10260 T10259 arg1Of methyltransferases,DNA
R8486 T10260 T10261 arg1Of methyltransferases,and
R8487 T10261 T10258 arg2Of and,of
R8488 T10263 T10261 arg2Of proteins,and
R8489 T10263 T10262 arg1Of proteins,methyl-CpG-binding
R8490 T10267 T10264 arg2Of associated,may
R8491 T10267 T10265 arg1Of associated,not
R8492 T10267 T10266 arg2Of associated,be
R8493 T10267 T10268 arg1Of associated,with
R8494 T10271 T10268 arg2Of methylation,with
R8495 T10271 T10269 arg1Of methylation,IRF-4
R8496 T10271 T10270 arg1Of methylation,promoter
R8497 T10273 T10274 arg1Of abundance,of
R8498 T10273 T10278 arg1Of abundance,contribute
R8499 T10275 T10276 arg1Of DNMT,and
R8500 T10276 T10274 arg2Of and,of
R8501 T10277 T10276 arg2Of MBP,and
R8502 T10278 T10272 arg2Of contribute,Since
R8503 T10278 T10279 arg1Of contribute,to
R8504 T10278 T10282 arg1Of contribute,via
R8505 T10281 T10279 arg2Of regulation,to
R8506 T10281 T10280 arg1Of regulation,promoter
R8507 T10283 T10282 arg2Of methylation,via
R8508 T10283 T10284 arg1Of methylation,(
R8509 T10285 T10284 arg2Of "25,26,28",(
R8510 T10286 T10284 arg3Of ),(
R8511 T10288 T10289 arg1Of we,studied
R8512 T10288 T10294 arg1Of we,investigate
R8513 T10289 T10272 arg1Of studied,Since
R8514 T10289 T10287 arg1Of studied,","
R8515 T10289 T10293 modOf studied,to
R8516 T10292 T10289 arg2Of expression,studied
R8517 T10292 T10290 arg1Of expression,their
R8518 T10292 T10291 arg1Of expression,mRNA
R8519 T10294 T10293 arg1Of investigate,to
R8520 T10297 T10294 arg2Of mechanism,investigate
R8521 T10297 T10295 arg1Of mechanism,a
R8522 T10297 T10296 arg1Of mechanism,possible
R8523 T10297 T10298 arg1Of mechanism,for
R8524 T10302 T10298 arg2Of differences,for
R8525 T10302 T10299 arg1Of differences,the
R8526 T10302 T10300 arg2Of differences,observed
R8527 T10302 T10301 arg1Of differences,methylation
R8528 T10302 T10303 arg1Of differences,in
R8529 T10306 T10303 arg2Of promoter,in
R8530 T10306 T10304 arg1Of promoter,the
R8531 T10306 T10305 arg1Of promoter,IRF-4
R8532 T10309 T10307 arg2Of end,To
R8533 T10309 T10308 arg1Of end,this
R8534 T10311 T10312 arg1Of we,did
R8535 T10311 T10314 arg1Of we,detect
R8536 T10314 T10307 arg1Of detect,To
R8537 T10314 T10310 arg1Of detect,","
R8538 T10314 T10312 arg2Of detect,did
R8539 T10314 T10313 arg1Of detect,not
R8540 T10317 T10316 arg1Of difference,significant
R8541 T10317 T10318 arg1Of difference,in
R8542 T10317 T10320 arg1Of difference,(
R8543 T10317 T10327 arg1Of difference,or
R8544 T10319 T10318 arg2Of DNMT,in
R8545 T10321 T10322 arg1Of DNMT1,","
R8546 T10322 T10324 arg1Of ",",and
R8547 T10323 T10322 arg2Of DNMT3A,","
R8548 T10324 T10320 arg2Of and,(
R8549 T10325 T10324 arg2Of DNMT3B,and
R8550 T10326 T10320 arg3Of ),(
R8551 T10327 T10314 arg2Of or,detect
R8552 T10327 T10315 arg1Of or,a
R8553 T10328 T10329 arg1Of MBP,(
R8554 T10330 T10331 arg1Of MBD1,","
R8555 T10331 T10333 arg1Of ",",","
R8556 T10332 T10331 arg2Of MBD2,","
R8557 T10333 T10335 arg1Of ",",and
R8558 T10334 T10333 arg2Of MBD4,","
R8559 T10335 T10329 arg2Of and,(
R8560 T10336 T10335 arg2Of MeCP,and
R8561 T10337 T10329 arg3Of ),(
R8562 T10339 T10327 arg2Of expression,or
R8563 T10339 T10328 arg1Of expression,MBP
R8564 T10339 T10338 arg1Of expression,mRNA
R8565 T10339 T10340 arg1Of expression,between
R8566 T10341 T10342 arg1Of IRF-4-positive,and
R8567 T10343 T10342 arg2Of -negative,and
R8568 T10344 T10340 arg2Of cells,between
R8569 T10344 T10341 arg1Of cells,IRF-4-positive
R8570 T10344 T10343 arg1Of cells,-negative
R8571 T10344 T10345 arg1Of cells,(
R8572 T10347 T10345 arg2Of 5D,(
R8573 T10347 T10346 arg1Of 5D,Figure
R8574 T10348 T10345 arg3Of ),(
R8575 T10350 T10349 arg2Of fact,In
R8576 T10354 T10352 arg1Of cells,all
R8577 T10354 T10353 arg2Of cells,analyzed
R8578 T10354 T10355 arg1Of cells,had
R8579 T10355 T10349 arg1Of had,In
R8580 T10355 T10351 arg1Of had,","
R8581 T10355 T10365 arg1Of had,and
R8582 T10358 T10356 arg1Of high,moderate
R8583 T10358 T10357 arg1Of high,to
R8584 T10360 T10355 arg2Of levels,had
R8585 T10360 T10358 arg1Of levels,high
R8586 T10360 T10359 arg1Of levels,mRNA
R8587 T10360 T10361 arg1Of levels,of
R8588 T10364 T10361 arg2Of DNMT/MBPs,of
R8589 T10364 T10362 arg1Of DNMT/MBPs,these
R8590 T10364 T10363 arg2Of DNMT/MBPs,tested
R8591 T10366 T10367 arg1Of differences,in
R8592 T10366 T10369 arg1Of differences,were
R8593 T10366 T10371 arg2Of differences,correlated
R8594 T10368 T10367 arg2Of expression,in
R8595 T10371 T10365 arg2Of correlated,and
R8596 T10371 T10369 arg2Of correlated,were
R8597 T10371 T10370 arg1Of correlated,not
R8598 T10371 T10372 arg1Of correlated,with
R8599 T10374 T10372 arg2Of status,with
R8600 T10374 T10373 arg1Of status,IRF-4
R8601 T10376 T10375 arg1Of results,These
R8602 T10376 T10377 arg1Of results,indicate
R8603 T10380 T10377 arg2Of cause,indicate
R8604 T10380 T10378 arg1Of cause,a
R8605 T10380 T10379 arg1Of cause,distinct
R8606 T10380 T10381 arg1Of cause,of
R8607 T10380 T10390 arg1Of cause,rather
R8608 T10384 T10381 arg2Of differences,of
R8609 T10384 T10382 arg1Of differences,the
R8610 T10384 T10383 arg1Of differences,methylation
R8611 T10384 T10385 arg1Of differences,in
R8612 T10386 T10387 arg1Of IRF-4-positive,and
R8613 T10388 T10387 arg2Of -negative,and
R8614 T10389 T10385 arg2Of cells,in
R8615 T10389 T10386 arg1Of cells,IRF-4-positive
R8616 T10389 T10388 arg1Of cells,-negative
R8617 T10390 T10391 arg1Of rather,than
R8618 T10392 T10391 arg2Of changes,than
R8619 T10392 T10393 arg1Of changes,in
R8620 T10395 T10396 arg1Of DNMT,and
R8621 T10397 T10396 arg2Of MBP,and
R8622 T10399 T10393 arg2Of transcription,in
R8623 T10399 T10394 arg1Of transcription,the
R8624 T10399 T10395 arg1Of transcription,DNMT
R8625 T10399 T10397 arg1Of transcription,MBP
R8626 T10399 T10398 arg1Of transcription,mRNA