pmc-enju-pas Home  

PMC:1134658 / 1403-4028 JSONTXT 17 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T1148 11-18 NN denotes Members
T1149 19-21 IN denotes of
T1150 22-25 DT denotes the
T1151 26-38 VB denotes transforming
T1152 39-45 NN denotes growth
T1153 46-52 NN denotes factor
T1154 53-54 NN denotes β
T1155 55-56 -LRB- denotes (
T1156 56-61 NN denotes TGF-β
T1157 61-62 -RRB- denotes )
T1158 63-74 NN denotes superfamily
T1159 75-79 VB denotes play
T1160 80-87 JJ denotes central
T1161 88-93 NN denotes roles
T1162 94-96 IN denotes in
T1163 97-108 VB denotes controlling
T1164 109-117 JJ denotes cellular
T1165 118-131 NN denotes proliferation
T1166 131-132 -COMMA- denotes ,
T1167 133-148 NN denotes differentiation
T1168 148-149 -COMMA- denotes ,
T1169 150-159 NN denotes migration
T1170 160-163 CC denotes and
T1171 164-173 NN denotes apoptosis
T1172 174-175 -LRB- denotes [
T1173 175-176 CD denotes 1
T1174 176-177 -RRB- denotes ]
T1175 179-184 DT denotes These
T1176 185-194 NN denotes cytokines
T1177 195-198 MD denotes can
T1178 199-201 VB denotes be
T1179 202-209 VB denotes divided
T1180 210-214 IN denotes into
T1181 215-220 CD denotes three
T1182 221-230 NN denotes subgroups
T1183 230-231 -COLON- denotes :
T1184 232-237 NN denotes TGF-β
T1185 237-238 -COMMA- denotes ,
T1186 239-242 DT denotes the
T1187 243-260 NN denotes activins/inhibins
T1188 260-261 -COMMA- denotes ,
T1189 262-265 CC denotes and
T1190 266-269 DT denotes the
T1191 270-274 NN denotes bone
T1192 275-288 JJ denotes morphogenetic
T1193 289-297 NN denotes proteins
T1194 298-299 -LRB- denotes (
T1195 299-303 NN denotes BMPs
T1196 303-304 -RRB- denotes )
T1197 304-305 -COMMA- denotes ,
T1198 306-308 IN denotes of
T1199 309-314 WDT denotes which
T1200 315-318 DT denotes the
T1201 319-325 JJ denotes latter
T1202 326-336 NN denotes constitute
T1203 337-340 DT denotes the
T1204 341-348 JJ denotes largest
T1205 349-355 NN denotes family
T1206 357-361 NN denotes BMPs
T1207 362-365 VB denotes are
T1208 366-371 CD denotes 30–38
T1209 372-375 NN denotes kDa
T1210 376-383 NN denotes hetero-
T1211 384-386 CC denotes or
T1212 387-398 JJ denotes homodimeric
T1213 399-407 NN denotes proteins
T1214 408-418 RB denotes originally
T1215 419-429 VB denotes identified
T1216 430-432 IN denotes by
T1217 433-438 PRP-DOLLAR- denotes their
T1218 439-446 NN denotes ability
T1219 447-449 TO denotes to
T1220 450-456 VB denotes induce
T1221 457-464 JJ denotes ectopic
T1222 465-474 NN denotes cartilage
T1223 475-478 CC denotes and
T1224 479-483 NN denotes bone
T1225 484-493 NN denotes formation
T1226 494-495 -LRB- denotes [
T1227 495-498 CD denotes 2,3
T1228 498-499 -RRB- denotes ]
T1229 501-508 JJ denotes Several
T1230 509-516 NN denotes studies
T1231 517-521 VB denotes have
T1232 522-534 VB denotes demonstrated
T1233 535-537 DT denotes an
T1234 538-547 JJ denotes essential
T1235 548-552 NN denotes role
T1236 553-555 IN denotes of
T1237 556-561 DT denotes these
T1238 562-570 NN denotes proteins
T1239 571-577 IN denotes during
T1240 578-591 NN denotes embryogenesis
T1241 591-592 -COMMA- denotes ,
T1242 593-596 CC denotes and
T1243 597-601 RB denotes more
T1244 602-610 RB denotes recently
T1245 610-611 -COMMA- denotes ,
T1246 612-616 RB denotes also
T1247 617-619 IN denotes in
T1248 620-625 JJ denotes adult
T1249 626-633 NN denotes tissues
T1250 634-635 -LRB- denotes [
T1251 635-636 CD denotes 1
T1252 636-637 -RRB- denotes ]
T1253 639-644 NN denotes TGF-β
T1254 645-648 VB denotes has
T1255 649-653 VB denotes been
T1256 654-665 RB denotes intensively
T1257 666-673 VB denotes studied
T1258 674-676 IN denotes in
T1259 677-683 JJ denotes normal
T1260 684-687 CC denotes and
T1261 688-697 JJ denotes malignant
T1262 698-712 JJ denotes haematopoietic
T1263 713-718 NN denotes cells
T1264 719-722 CC denotes and
T1265 723-725 VB denotes is
T1266 726-729 CD denotes one
T1267 730-732 IN denotes of
T1268 733-736 DT denotes the
T1269 737-741 RB denotes most
T1270 742-748 JJ denotes potent
T1271 749-759 JJ denotes endogenous
T1272 760-768 JJ denotes negative
T1273 769-779 NN denotes regulators
T1274 780-785 VB denotes known
T1275 786-788 TO denotes to
T1276 789-794 NN denotes date.
T1277 795-796 -LRB- denotes [
T1278 796-797 CD denotes 4
T1279 797-798 -RRB- denotes ]
T1280 800-802 IN denotes In
T1281 803-811 NN denotes contrast
T1282 811-812 -COMMA- denotes ,
T1283 813-816 DT denotes the
T1284 817-823 NN denotes effect
T1285 824-826 IN denotes of
T1286 827-831 NN denotes BMPs
T1287 832-834 IN denotes in
T1288 835-838 DT denotes the
T1289 839-845 JJ denotes immune
T1290 846-852 NN denotes system
T1291 853-856 VB denotes has
T1292 857-860 RB denotes not
T1293 861-865 VB denotes been
T1294 866-872 RB denotes widely
T1295 873-885 VB denotes investigated
T1296 887-889 IN denotes In
T1297 890-894 DT denotes that
T1298 895-902 NN denotes respect
T1299 902-903 -COMMA- denotes ,
T1300 904-908 NN denotes BMP-
T1301 909-910 CD denotes 2
T1302 910-911 -COMMA- denotes ,
T1303 912-914 CD denotes -4
T1304 915-918 CC denotes and
T1305 919-921 CD denotes -7
T1306 922-926 VB denotes have
T1307 927-931 VB denotes been
T1308 932-937 VB denotes found
T1309 938-940 TO denotes to
T1310 941-948 VB denotes control
T1311 949-964 NN denotes differentiation
T1312 965-967 IN denotes of
T1313 968-981 JJ denotes hematopoietic
T1314 982-986 NN denotes stem
T1315 987-992 NN denotes cells
T1316 993-994 -LRB- denotes [
T1317 994-995 CD denotes 5
T1318 995-996 -RRB- denotes ]
T1319 997-1000 CC denotes and
T1320 1001-1006 JJ denotes early
T1321 1007-1008 NN denotes T
T1322 1009-1013 NN denotes cell
T1323 1014-1025 NN denotes development
T1324 1026-1027 -LRB- denotes [
T1325 1027-1030 CD denotes 6,7
T1326 1030-1031 -RRB- denotes ]
T1327 1033-1038 NN denotes BMP-6
T1328 1039-1042 VB denotes has
T1329 1043-1047 VB denotes been
T1330 1048-1056 VB denotes reported
T1331 1057-1059 TO denotes to
T1332 1060-1066 VB denotes reduce
T1333 1067-1070 DT denotes the
T1334 1071-1077 NN denotes number
T1335 1078-1080 IN denotes of
T1336 1081-1105 JJ denotes cobblestone-area-forming
T1337 1106-1111 NN denotes cells
T1338 1112-1114 IN denotes of
T1339 1115-1121 JJ denotes normal
T1340 1122-1127 JJ denotes human
T1341 1128-1142 JJ denotes haematopoietic
T1342 1143-1148 NN denotes cells
T1343 1149-1150 -LRB- denotes [
T1344 1150-1151 CD denotes 8
T1345 1151-1152 -RRB- denotes ]
T1346 1154-1165 RB denotes Furthermore
T1347 1165-1166 -COMMA- denotes ,
T1348 1167-1172 NN denotes BMP-2
T1349 1172-1173 -COMMA- denotes ,
T1350 1174-1176 CD denotes -4
T1351 1176-1177 -COMMA- denotes ,
T1352 1178-1179 CD denotes 6
T1353 1180-1183 CC denotes and
T1354 1184-1186 CD denotes -7
T1355 1187-1190 VB denotes had
T1356 1191-1193 DT denotes an
T1357 1194-1211 JJ denotes antiproliferative
T1358 1212-1215 CC denotes and
T1359 1216-1217 DT denotes a
T1360 1218-1230 JJ denotes proapoptotic
T1361 1231-1237 NN denotes effect
T1362 1238-1240 IN denotes on
T1363 1241-1249 JJ denotes multiple
T1364 1250-1257 NN denotes myeloma
T1365 1258-1263 NN denotes cells
T1366 1264-1265 -LRB- denotes [
T1367 1265-1269 CD denotes 9-11
T1368 1269-1270 -RRB- denotes ]
T1369 1272-1274 IN denotes In
T1370 1275-1283 NN denotes addition
T1371 1283-1284 -COMMA- denotes ,
T1372 1285-1287 IN denotes by
T1373 1288-1292 NN denotes gene
T1374 1293-1303 NN denotes expression
T1375 1304-1313 NN denotes profiling
T1376 1313-1314 -COMMA- denotes ,
T1377 1315-1320 NN denotes BMP-6
T1378 1321-1334 RB denotes significantly
T1379 1335-1344 VB denotes increased
T1380 1345-1348 DT denotes the
T1381 1349-1359 JJ denotes predictive
T1382 1360-1365 NN denotes value
T1383 1366-1369 IN denotes for
T1384 1370-1371 DT denotes a
T1385 1372-1382 JJ denotes multi-gene
T1386 1383-1392 NN denotes signature
T1387 1393-1397 NN denotes test
T1388 1398-1401 CC denotes and
T1389 1402-1405 VB denotes was
T1390 1406-1416 VB denotes associated
T1391 1417-1421 IN denotes with
T1392 1422-1423 DT denotes a
T1393 1424-1428 JJ denotes poor
T1394 1429-1436 NN denotes outcome
T1395 1437-1439 IN denotes in
T1396 1440-1447 JJ denotes diffuse
T1397 1448-1453 JJ denotes large
T1398 1454-1455 NN denotes B
T1399 1456-1460 NN denotes cell
T1400 1461-1470 NN denotes lymphomas
T1401 1471-1472 -LRB- denotes (
T1402 1472-1477 NN denotes DLBCL
T1403 1477-1478 -RRB- denotes )
T1404 1479-1480 -LRB- denotes [
T1405 1480-1482 CD denotes 12
T1406 1482-1483 -RRB- denotes ]
T1407 1485-1490 NN denotes BMP-6
T1408 1490-1491 -COMMA- denotes ,
T1409 1492-1496 IN denotes like
T1410 1497-1500 DT denotes the
T1411 1501-1506 JJ denotes other
T1412 1507-1510 NN denotes BMP
T1413 1511-1518 NN denotes members
T1414 1518-1519 -COMMA- denotes ,
T1415 1520-1527 NN denotes signals
T1416 1528-1535 IN denotes through
T1417 1536-1544 NN denotes ligation
T1418 1545-1548 CC denotes and
T1419 1549-1566 NN denotes heterodimerzation
T1420 1567-1569 IN denotes of
T1421 1570-1573 NN denotes BMP
T1422 1574-1578 NN denotes type
T1423 1579-1580 CD denotes I
T1424 1581-1582 -LRB- denotes [
T1425 1582-1601 NN denotes activin-like-kinase
T1426 1602-1603 -LRB- denotes (
T1427 1603-1606 NN denotes ALK
T1428 1606-1607 -RRB- denotes )
T1429 1607-1608 -RRB- denotes ]
T1430 1609-1612 CC denotes and
T1431 1613-1617 NN denotes type
T1432 1618-1620 CD denotes II
T1433 1621-1637 NN denotes serine-threonine
T1434 1638-1644 NN denotes kinase
T1435 1645-1654 NN denotes receptors
T1436 1654-1655 -COMMA- denotes ,
T1437 1656-1661 WDT denotes which
T1438 1662-1674 RB denotes subsequently
T1439 1675-1685 VB denotes propagates
T1440 1686-1689 DT denotes the
T1441 1690-1696 NN denotes signal
T1442 1697-1707 RB denotes downstream
T1443 1708-1710 IN denotes by
T1444 1711-1726 VB denotes phosphorylating
T1445 1727-1731 NN denotes Smad
T1446 1732-1740 NN denotes proteins
T1447 1742-1747 NN denotes BMP-6
T1448 1748-1751 MD denotes can
T1449 1752-1758 VB denotes signal
T1450 1759-1766 IN denotes through
T1451 1767-1770 DT denotes the
T1452 1771-1779 NN denotes ligation
T1453 1780-1782 IN denotes of
T1454 1783-1786 DT denotes the
T1455 1787-1791 NN denotes type
T1456 1792-1793 CD denotes I
T1457 1794-1803 NN denotes receptors
T1458 1804-1811 NNP denotes Act-RIA
T1459 1811-1812 -COMMA- denotes ,
T1460 1813-1820 NN denotes BMP-RIA
T1461 1820-1821 -COMMA- denotes ,
T1462 1822-1825 CC denotes and
T1463 1826-1833 NN denotes BMP-RIB
T1464 1834-1837 CC denotes and
T1465 1838-1841 DT denotes the
T1466 1842-1846 NN denotes type
T1467 1847-1849 CD denotes II
T1468 1850-1859 NN denotes receptors
T1469 1860-1867 NN denotes BMP-RII
T1470 1867-1868 -COMMA- denotes ,
T1471 1869-1877 NN denotes Act-RIIA
T1472 1878-1881 CC denotes and
T1473 1882-1890 NN denotes Act-RIIB
T1474 1890-1891 -COMMA- denotes ,
T1475 1892-1897 WDT denotes which
T1476 1898-1902 VB denotes lead
T1477 1903-1905 TO denotes to
T1478 1906-1909 DT denotes the
T1479 1910-1925 NN denotes phosphorylation
T1480 1926-1928 IN denotes of
T1481 1929-1932 DT denotes the
T1482 1933-1941 NN denotes receptor
T1483 1942-1947 NN denotes Smads
T1484 1948-1949 -LRB- denotes (
T1485 1949-1955 NN denotes Smad-1
T1486 1955-1956 -COMMA- denotes ,
T1487 1957-1963 NN denotes Smad-5
T1488 1963-1964 -COMMA- denotes ,
T1489 1965-1968 CC denotes and
T1490 1969-1975 NN denotes Smad-8
T1491 1975-1976 -RRB- denotes )
T1492 1978-1981 DT denotes The
T1493 1982-1984 NN denotes R-
T1494 1985-1990 NN denotes Smads
T1495 1991-1995 RB denotes then
T1496 1996-2000 VB denotes form
T1497 2001-2010 NN denotes complexes
T1498 2011-2015 IN denotes with
T1499 2016-2019 DT denotes the
T1500 2020-2027 NN denotes co-Smad
T1501 2028-2029 -LRB- denotes (
T1502 2029-2034 NN denotes Smad4
T1503 2034-2035 -RRB- denotes )
T1504 2036-2039 CC denotes and
T1505 2040-2043 VB denotes are
T1506 2044-2056 VB denotes translocated
T1507 2057-2061 IN denotes into
T1508 2062-2065 DT denotes the
T1509 2066-2073 NN denotes nucleus
T1510 2074-2079 WRB denotes where
T1511 2080-2084 PRP denotes they
T1512 2085-2090 VB denotes exert
T1513 2091-2095 NN denotes gene
T1514 2096-2106 NN denotes regulation
T1515 2107-2108 -LRB- denotes [
T1516 2108-2112 CD denotes 1,13
T1517 2112-2113 -RRB- denotes ]
T1518 2115-2120 VB denotes Given
T1519 2121-2124 DT denotes the
T1520 2125-2133 VB denotes reported
T1521 2134-2138 NN denotes role
T1522 2139-2141 IN denotes of
T1523 2142-2147 NN denotes BMP-6
T1524 2148-2150 IN denotes in
T1525 2151-2157 NN denotes B-cell
T1526 2158-2170 NN denotes malignancies
T1527 2171-2174 CC denotes and
T1528 2175-2189 JJ denotes haematopoietic
T1529 2190-2200 NN denotes progenitor
T1530 2201-2206 NN denotes cells
T1531 2206-2207 -COMMA- denotes ,
T1532 2208-2210 PRP denotes we
T1533 2211-2217 VB denotes wanted
T1534 2218-2220 TO denotes to
T1535 2221-2228 VB denotes explore
T1536 2229-2232 PRP-DOLLAR- denotes its
T1537 2233-2242 JJ denotes potential
T1538 2243-2247 NN denotes role
T1539 2248-2250 IN denotes in
T1540 2251-2257 JJ denotes normal
T1541 2258-2263 JJ denotes human
T1542 2264-2265 NN denotes B
T1543 2266-2271 NN denotes cells
T1544 2273-2275 PRP denotes We
T1545 2276-2283 VB denotes studied
T1546 2284-2287 DT denotes the
T1547 2288-2295 NN denotes effects
T1548 2296-2298 IN denotes of
T1549 2299-2304 NN denotes BMP-6
T1550 2305-2307 IN denotes on
T1551 2308-2321 NN denotes proliferation
T1552 2322-2325 CC denotes and
T1553 2326-2335 NN denotes apoptosis
T1554 2336-2338 IN denotes on
T1555 2339-2346 VB denotes resting
T1556 2347-2350 CC denotes and
T1557 2351-2361 VB denotes stimulated
T1558 2362-2363 NN denotes B
T1559 2364-2369 NN denotes cells
T1560 2371-2382 RB denotes Furthermore
T1561 2382-2383 -COMMA- denotes ,
T1562 2384-2387 DT denotes the
T1563 2388-2398 NN denotes expression
T1564 2399-2401 IN denotes of
T1565 2402-2405 NN denotes BMP
T1566 2406-2415 NN denotes receptors
T1567 2416-2419 CC denotes and
T1568 2420-2425 NN denotes BMP-6
T1569 2426-2433 VB denotes induced
T1570 2434-2444 NN denotes activation
T1571 2445-2447 IN denotes of
T1572 2448-2451 DT denotes the
T1573 2452-2456 NN denotes Smad
T1574 2457-2467 NN denotes signalling
T1575 2468-2475 NN denotes pathway
T1576 2476-2480 IN denotes with
T1577 2481-2491 JJ denotes subsequent
T1578 2492-2502 NN denotes regulation
T1579 2503-2505 IN denotes of
T1580 2506-2509 DT denotes the
T1581 2510-2516 NN denotes target
T1582 2517-2522 NN denotes genes
T1583 2523-2530 NN denotes Id1–Id4
T1584 2530-2531 -COMMA- denotes ,
T1585 2532-2536 VB denotes were
T1586 2537-2545 VB denotes resolved
T1587 2547-2554 RB denotes Finally
T1588 2554-2555 -COMMA- denotes ,
T1589 2556-2558 PRP denotes we
T1590 2559-2571 VB denotes investigated
T1591 2572-2579 IN denotes whether
T1592 2580-2581 NN denotes B
T1593 2582-2587 NN denotes cells
T1594 2588-2592 RB denotes also
T1595 2593-2597 VB denotes were
T1596 2598-2605 JJ denotes capable
T1597 2606-2608 IN denotes of
T1598 2609-2618 VB denotes producing
T1599 2619-2624 NN denotes BMP-6
R1000 T1295 T1293 arg2Of investigated,been
R1001 T1295 T1294 arg1Of investigated,widely
R1002 T1298 T1296 arg2Of respect,In
R1003 T1298 T1297 arg1Of respect,that
R1004 T1300 T1301 arg1Of BMP-,2
R1005 T1300 T1302 arg1Of BMP-,","
R1006 T1302 T1304 arg1Of ",",and
R1007 T1303 T1302 arg2Of -4,","
R1008 T1304 T1306 arg1Of and,have
R1009 T1304 T1307 arg1Of and,been
R1010 T1304 T1308 arg2Of and,found
R1011 T1304 T1310 arg1Of and,control
R1012 T1305 T1304 arg2Of -7,and
R1013 T1308 T1296 arg1Of found,In
R1014 T1308 T1299 arg1Of found,","
R1015 T1308 T1306 arg2Of found,have
R1016 T1308 T1307 arg2Of found,been
R1017 T1310 T1308 arg3Of control,found
R1018 T1310 T1309 arg1Of control,to
R1019 T1311 T1312 arg1Of differentiation,of
R1020 T1311 T1319 arg1Of differentiation,and
R1021 T1315 T1312 arg2Of cells,of
R1022 T1315 T1313 arg1Of cells,hematopoietic
R1023 T1315 T1314 arg1Of cells,stem
R1024 T1315 T1316 arg1Of cells,[
R1025 T1317 T1316 arg2Of 5,[
R1026 T1318 T1316 arg3Of ],[
R1027 T1319 T1310 arg2Of and,control
R1028 T1323 T1319 arg2Of development,and
R1029 T1323 T1320 arg1Of development,early
R1030 T1323 T1321 arg1Of development,T
R1031 T1323 T1322 arg1Of development,cell
R1032 T1323 T1324 arg1Of development,[
R1033 T1325 T1324 arg2Of "6,7",[
R1034 T1326 T1324 arg3Of ],[
R1035 T1327 T1328 arg1Of BMP-6,has
R1036 T1327 T1329 arg1Of BMP-6,been
R1037 T1327 T1330 arg2Of BMP-6,reported
R1038 T1327 T1332 arg1Of BMP-6,reduce
R1039 T1330 T1328 arg2Of reported,has
R1040 T1330 T1329 arg2Of reported,been
R1041 T1332 T1330 arg3Of reduce,reported
R1042 T1332 T1331 arg1Of reduce,to
R1043 T1334 T1332 arg2Of number,reduce
R1044 T1334 T1333 arg1Of number,the
R1045 T1334 T1335 arg1Of number,of
R1046 T1337 T1335 arg2Of cells,of
R1047 T1337 T1336 arg1Of cells,cobblestone-area-forming
R1048 T1337 T1338 arg1Of cells,of
R1049 T1342 T1338 arg2Of cells,of
R1050 T1342 T1339 arg1Of cells,normal
R1051 T1342 T1340 arg1Of cells,human
R1052 T1342 T1341 arg1Of cells,haematopoietic
R1053 T1342 T1343 arg1Of cells,[
R1054 T1344 T1343 arg2Of 8,[
R1055 T1345 T1343 arg3Of ],[
R1056 T1348 T1349 arg1Of BMP-2,","
R1057 T1349 T1351 arg1Of ",",","
R1058 T1350 T1349 arg2Of -4,","
R1059 T1351 T1353 arg1Of ",",and
R1060 T1352 T1351 arg2Of 6,","
R1061 T1353 T1355 arg1Of and,had
R1062 T1354 T1353 arg2Of -7,and
R1063 T1355 T1346 arg1Of had,Furthermore
R1064 T1355 T1347 arg1Of had,","
R1065 T1355 T1362 arg1Of had,on
R1066 T1357 T1358 arg1Of antiproliferative,and
R1067 T1360 T1358 arg2Of proapoptotic,and
R1068 T1360 T1359 arg1Of proapoptotic,a
R1069 T1361 T1355 arg2Of effect,had
R1070 T1361 T1356 arg1Of effect,an
R1071 T1361 T1357 arg1Of effect,antiproliferative
R1072 T1361 T1360 arg1Of effect,proapoptotic
R1073 T1365 T1362 arg2Of cells,on
R1074 T1365 T1363 arg1Of cells,multiple
R1075 T1365 T1364 arg1Of cells,myeloma
R1076 T1365 T1366 arg1Of cells,[
R1077 T1367 T1366 arg2Of 9-11,[
R1078 T1368 T1366 arg3Of ],[
R1079 T1370 T1369 arg2Of addition,In
R1080 T1375 T1372 arg2Of profiling,by
R1081 T1375 T1373 arg1Of profiling,gene
R1082 T1375 T1374 arg1Of profiling,expression
R1083 T1377 T1379 arg1Of BMP-6,increased
R1084 T1377 T1389 arg1Of BMP-6,was
R1085 T1377 T1390 arg2Of BMP-6,associated
R1086 T1379 T1388 arg1Of increased,and
R1087 T1382 T1379 arg2Of value,increased
R1088 T1382 T1380 arg1Of value,the
R1089 T1382 T1381 arg1Of value,predictive
R1090 T1382 T1383 arg1Of value,for
R1091 T1387 T1383 arg2Of test,for
R1092 T1387 T1384 arg1Of test,a
R1093 T1387 T1385 arg1Of test,multi-gene
R1094 T1387 T1386 arg1Of test,signature
R1095 T1388 T1369 arg1Of and,In
R1096 T1388 T1371 arg1Of and,","
R1097 T1388 T1372 arg1Of and,by
R1098 T1388 T1376 arg1Of and,","
R1099 T1388 T1378 arg1Of and,significantly
R1100 T1390 T1388 arg2Of associated,and
R1101 T1390 T1389 arg2Of associated,was
R1102 T1390 T1391 arg1Of associated,with
R1103 T1390 T1404 arg1Of associated,[
R1104 T1394 T1391 arg2Of outcome,with
R1105 T1394 T1392 arg1Of outcome,a
R1106 T1394 T1393 arg1Of outcome,poor
R1107 T1394 T1395 arg1Of outcome,in
R1108 T1400 T1395 arg2Of lymphomas,in
R1109 T1400 T1396 arg1Of lymphomas,diffuse
R1110 T1400 T1397 arg1Of lymphomas,large
R1111 T1400 T1398 arg1Of lymphomas,B
R1112 T1400 T1399 arg1Of lymphomas,cell
R1113 T1400 T1401 arg1Of lymphomas,(
R1114 T1402 T1401 arg2Of DLBCL,(
R1115 T1403 T1401 arg3Of ),(
R1116 T1405 T1404 arg2Of 12,[
R1117 T1406 T1404 arg3Of ],[
R1118 T1407 T1408 arg1Of BMP-6,","
R1119 T1407 T1409 arg1Of BMP-6,like
R1120 T1407 T1414 arg1Of BMP-6,","
R1121 T1413 T1409 arg2Of members,like
R1122 T1413 T1410 arg1Of members,the
R1123 T1413 T1411 arg1Of members,other
R1124 T1413 T1412 arg1Of members,BMP
R1125 T1414 T1416 arg1Of ",",through
R1126 T1414 T1424 arg1Of ",",[
R1127 T1414 T1430 arg1Of ",",and
R1128 T1415 T1414 arg2Of signals,","
R1129 T1417 T1418 arg1Of ligation,and
R1130 T1418 T1416 arg2Of and,through
R1131 T1418 T1420 arg1Of and,of
R1132 T1419 T1418 arg2Of heterodimerzation,and
R1133 T1422 T1420 arg2Of type,of
R1134 T1422 T1421 arg1Of type,BMP
R1135 T1422 T1423 arg1Of type,I
R1136 T1425 T1424 arg2Of activin-like-kinase,[
R1137 T1425 T1426 arg1Of activin-like-kinase,(
R1138 T1427 T1426 arg2Of ALK,(
R1139 T1428 T1426 arg3Of ),(
R1140 T1429 T1424 arg3Of ],[
R1141 T1430 T1436 arg1Of and,","
R1142 T1430 T1437 arg1Of and,which
R1143 T1430 T1439 arg1Of and,propagates
R1144 T1435 T1430 arg2Of receptors,and
R1145 T1435 T1431 arg1Of receptors,type
R1146 T1435 T1432 arg1Of receptors,II
R1147 T1435 T1433 arg1Of receptors,serine-threonine
R1148 T1435 T1434 arg1Of receptors,kinase
R1149 T1439 T1438 arg1Of propagates,subsequently
R1150 T1439 T1442 arg1Of propagates,downstream
R1151 T1439 T1443 arg1Of propagates,by
R1152 T1441 T1439 arg2Of signal,propagates
R1153 T1441 T1440 arg1Of signal,the
R1154 T1444 T1443 arg2Of phosphorylating,by
R1155 T1446 T1444 arg2Of proteins,phosphorylating
R1156 T1446 T1445 arg1Of proteins,Smad
R1157 T1447 T1448 arg1Of BMP-6,can
R1158 T1447 T1449 arg1Of BMP-6,signal
R1159 T1449 T1448 arg2Of signal,can
R1160 T1449 T1450 arg1Of signal,through
R1161 T1452 T1450 arg2Of ligation,through
R1162 T1452 T1451 arg1Of ligation,the
R1163 T1452 T1453 arg1Of ligation,of
R1164 T1452 T1474 arg1Of ligation,","
R1165 T1452 T1475 arg1Of ligation,which
R1166 T1452 T1476 arg1Of ligation,lead
R1167 T1457 T1455 arg1Of receptors,type
R1168 T1457 T1456 arg1Of receptors,I
R1169 T1458 T1459 arg1Of Act-RIA,","
R1170 T1459 T1457 arg1Of ",",receptors
R1171 T1459 T1462 arg1Of ",",and
R1172 T1460 T1459 arg2Of BMP-RIA,","
R1173 T1462 T1454 arg1Of and,the
R1174 T1462 T1461 arg1Of and,","
R1175 T1462 T1464 arg1Of and,and
R1176 T1463 T1462 arg2Of BMP-RIB,and
R1177 T1464 T1453 arg2Of and,of
R1178 T1468 T1466 arg1Of receptors,type
R1179 T1468 T1467 arg1Of receptors,II
R1180 T1469 T1470 arg1Of BMP-RII,","
R1181 T1470 T1472 arg1Of ",",and
R1182 T1471 T1470 arg2Of Act-RIIA,","
R1183 T1472 T1464 arg2Of and,and
R1184 T1472 T1465 arg1Of and,the
R1185 T1472 T1468 arg1Of and,receptors
R1186 T1473 T1472 arg2Of Act-RIIB,and
R1187 T1476 T1477 arg1Of lead,to
R1188 T1479 T1477 arg2Of phosphorylation,to
R1189 T1479 T1478 arg1Of phosphorylation,the
R1190 T1479 T1480 arg1Of phosphorylation,of
R1191 T1483 T1480 arg2Of Smads,of
R1192 T1483 T1481 arg1Of Smads,the
R1193 T1483 T1482 arg1Of Smads,receptor
R1194 T1483 T1484 arg1Of Smads,(
R1195 T1485 T1486 arg1Of Smad-1,","
R1196 T1486 T1489 arg1Of ",",and
R1197 T1487 T1486 arg2Of Smad-5,","
R1198 T1489 T1484 arg2Of and,(
R1199 T1489 T1488 arg1Of and,","
R1200 T1490 T1489 arg2Of Smad-8,and
R1201 T1491 T1484 arg3Of ),(
R1202 T1494 T1492 arg1Of Smads,The
R1203 T1494 T1493 arg1Of Smads,R-
R1204 T1494 T1496 arg1Of Smads,form
R1205 T1494 T1505 arg1Of Smads,are
R1206 T1494 T1506 arg2Of Smads,translocated
R1207 T1496 T1498 arg1Of form,with
R1208 T1496 T1504 arg1Of form,and
R1209 T1497 T1496 arg2Of complexes,form
R1210 T1500 T1498 arg2Of co-Smad,with
R1211 T1500 T1499 arg1Of co-Smad,the
R1212 T1500 T1501 arg1Of co-Smad,(
R1213 T1502 T1501 arg2Of Smad4,(
R1214 T1503 T1501 arg3Of ),(
R1215 T1504 T1495 arg1Of and,then
R1216 T1506 T1504 arg2Of translocated,and
R1217 T1506 T1505 arg2Of translocated,are
R1218 T1506 T1507 arg1Of translocated,into
R1219 T1509 T1507 arg2Of nucleus,into
R1220 T1509 T1508 arg1Of nucleus,the
R1221 T1509 T1510 arg1Of nucleus,where
R1222 T1511 T1512 arg1Of they,exert
R1223 T1512 T1510 arg2Of exert,where
R1224 T1512 T1515 arg1Of exert,[
R1225 T1514 T1512 arg2Of regulation,exert
R1226 T1514 T1513 arg1Of regulation,gene
R1227 T1516 T1515 arg2Of "1,13",[
R1228 T1517 T1515 arg3Of ],[
R1229 T1521 T1518 arg2Of role,Given
R1230 T1521 T1519 arg1Of role,the
R1231 T1521 T1520 arg2Of role,reported
R1232 T1521 T1522 arg1Of role,of
R1233 T1521 T1524 arg1Of role,in
R1234 T1523 T1522 arg2Of BMP-6,of
R1235 T1526 T1525 arg1Of malignancies,B-cell
R1236 T1526 T1527 arg1Of malignancies,and
R1237 T1527 T1524 arg2Of and,in
R1238 T1530 T1527 arg2Of cells,and
R1239 T1530 T1528 arg1Of cells,haematopoietic
R1240 T1530 T1529 arg1Of cells,progenitor
R1241 T1532 T1533 arg1Of we,wanted
R1242 T1532 T1535 arg1Of we,explore
R1243 T1533 T1518 arg1Of wanted,Given
R1244 T1533 T1531 arg1Of wanted,","
R1245 T1535 T1533 arg2Of explore,wanted
R1246 T1535 T1534 arg1Of explore,to
R1247 T1535 T1539 arg1Of explore,in
R1248 T1538 T1535 arg2Of role,explore
R1249 T1538 T1536 arg1Of role,its
R1250 T1538 T1537 arg1Of role,potential
R1251 T1543 T1539 arg2Of cells,in
R1252 T1543 T1540 arg1Of cells,normal
R1253 T1543 T1541 arg1Of cells,human
R1254 T1543 T1542 arg1Of cells,B
R1255 T1544 T1545 arg1Of We,studied
R1256 T1547 T1545 arg2Of effects,studied
R1257 T1547 T1546 arg1Of effects,the
R1258 T1547 T1548 arg1Of effects,of
R1259 T1547 T1550 arg1Of effects,on
R1260 T1549 T1548 arg2Of BMP-6,of
R1261 T1551 T1552 arg1Of proliferation,and
R1262 T1552 T1550 arg2Of and,on
R1263 T1552 T1554 arg1Of and,on
R1264 T1553 T1552 arg2Of apoptosis,and
R1265 T1559 T1554 arg2Of cells,on
R1266 T1559 T1555 arg1Of cells,resting
R1267 T1559 T1556 arg1Of cells,and
R1268 T1559 T1557 arg2Of cells,stimulated
R1269 T1559 T1558 arg1Of cells,B
R1270 T1563 T1562 arg1Of expression,the
R1271 T1563 T1564 arg1Of expression,of
R1272 T1563 T1569 arg1Of expression,induced
R1273 T1563 T1585 arg1Of expression,were
R1274 T1563 T1586 arg2Of expression,resolved
R1275 T1566 T1565 arg1Of receptors,BMP
R1276 T1566 T1567 arg1Of receptors,and
R1277 T1567 T1564 arg2Of and,of
R1278 T1568 T1567 arg2Of BMP-6,and
R1279 T1569 T1576 arg1Of induced,with
R1280 T1569 T1584 arg1Of induced,","
R1281 T1570 T1569 arg2Of activation,induced
R1282 T1570 T1571 arg1Of activation,of
R1283 T1575 T1571 arg2Of pathway,of
R1284 T1575 T1572 arg1Of pathway,the
R1285 T1575 T1573 arg1Of pathway,Smad
R1286 T1575 T1574 arg1Of pathway,signalling
R1287 T1578 T1576 arg2Of regulation,with
R1288 T1578 T1577 arg1Of regulation,subsequent
R1289 T1578 T1579 arg1Of regulation,of
R1290 T1583 T1579 arg2Of Id1–Id4,of
R1291 T1583 T1580 arg1Of Id1–Id4,the
R1292 T1583 T1581 arg1Of Id1–Id4,target
R1293 T1583 T1582 arg1Of Id1–Id4,genes
R1294 T1584 T1560 arg1Of ",",Furthermore
R1295 T1584 T1561 arg1Of ",",","
R1296 T1586 T1584 arg2Of resolved,","
R1297 T1586 T1585 arg2Of resolved,were
R1298 T1589 T1590 arg1Of we,investigated
R1299 T1590 T1587 arg1Of investigated,Finally
R1300 T1590 T1588 arg1Of investigated,","
R1301 T1593 T1592 arg1Of cells,B
R1302 T1593 T1595 arg1Of cells,were
R1303 T1593 T1596 arg1Of cells,capable
R1304 T1593 T1598 arg1Of cells,producing
R1305 T1595 T1590 arg2Of were,investigated
R1306 T1595 T1591 arg1Of were,whether
R1307 T1595 T1594 arg1Of were,also
R1308 T1596 T1595 arg2Of capable,were
R1309 T1596 T1597 arg1Of capable,of
R1310 T1598 T1597 arg2Of producing,of
R1311 T1599 T1598 arg2Of BMP-6,producing
R849 T1148 T1149 arg1Of Members,of
R850 T1148 T1159 arg1Of Members,play
R851 T1148 T1163 arg1Of Members,controlling
R852 T1154 T1152 arg1Of β,growth
R853 T1154 T1153 arg1Of β,factor
R854 T1154 T1155 arg1Of β,(
R855 T1156 T1155 arg2Of TGF-β,(
R856 T1157 T1155 arg3Of ),(
R857 T1158 T1149 arg2Of superfamily,of
R858 T1158 T1150 arg1Of superfamily,the
R859 T1158 T1151 arg1Of superfamily,transforming
R860 T1158 T1154 arg1Of superfamily,β
R861 T1159 T1162 arg1Of play,in
R862 T1161 T1159 arg2Of roles,play
R863 T1161 T1160 arg1Of roles,central
R864 T1163 T1162 arg2Of controlling,in
R865 T1165 T1164 arg1Of proliferation,cellular
R866 T1165 T1166 arg1Of proliferation,","
R867 T1166 T1168 arg1Of ",",","
R868 T1167 T1166 arg2Of differentiation,","
R869 T1168 T1170 arg1Of ",",and
R870 T1169 T1168 arg2Of migration,","
R871 T1170 T1163 arg2Of and,controlling
R872 T1171 T1170 arg2Of apoptosis,and
R873 T1171 T1172 arg1Of apoptosis,[
R874 T1173 T1172 arg2Of 1,[
R875 T1174 T1172 arg3Of ],[
R876 T1176 T1175 arg1Of cytokines,These
R877 T1176 T1177 arg1Of cytokines,can
R878 T1176 T1178 arg1Of cytokines,be
R879 T1176 T1179 arg2Of cytokines,divided
R880 T1179 T1177 arg2Of divided,can
R881 T1179 T1178 arg2Of divided,be
R882 T1179 T1180 arg1Of divided,into
R883 T1182 T1180 arg2Of subgroups,into
R884 T1182 T1181 arg1Of subgroups,three
R885 T1182 T1183 arg1Of subgroups,:
R886 T1184 T1185 arg1Of TGF-β,","
R887 T1184 T1189 arg1Of TGF-β,and
R888 T1187 T1185 arg2Of activins/inhibins,","
R889 T1187 T1186 arg1Of activins/inhibins,the
R890 T1189 T1183 arg2Of and,:
R891 T1189 T1188 arg1Of and,","
R892 T1193 T1189 arg2Of proteins,and
R893 T1193 T1190 arg1Of proteins,the
R894 T1193 T1191 arg1Of proteins,bone
R895 T1193 T1192 arg1Of proteins,morphogenetic
R896 T1193 T1194 arg1Of proteins,(
R897 T1193 T1197 arg1Of proteins,","
R898 T1193 T1198 arg2Of proteins,of
R899 T1193 T1199 arg1Of proteins,which
R900 T1195 T1194 arg2Of BMPs,(
R901 T1196 T1194 arg3Of ),(
R902 T1201 T1200 arg1Of latter,the
R903 T1201 T1202 arg1Of latter,constitute
R904 T1202 T1198 arg1Of constitute,of
R905 T1205 T1202 arg2Of family,constitute
R906 T1205 T1203 arg1Of family,the
R907 T1205 T1204 arg1Of family,largest
R908 T1206 T1207 arg1Of BMPs,are
R909 T1208 T1209 arg1Of 30–38,kDa
R910 T1208 T1210 arg1Of 30–38,hetero-
R911 T1208 T1211 arg1Of 30–38,or
R912 T1212 T1211 arg2Of homodimeric,or
R913 T1213 T1207 arg2Of proteins,are
R914 T1213 T1208 arg1Of proteins,30–38
R915 T1213 T1212 arg1Of proteins,homodimeric
R916 T1213 T1215 arg2Of proteins,identified
R917 T1215 T1214 arg1Of identified,originally
R918 T1218 T1215 arg1Of ability,identified
R919 T1218 T1216 arg2Of ability,by
R920 T1218 T1217 arg1Of ability,their
R921 T1218 T1219 modOf ability,to
R922 T1220 T1219 arg1Of induce,to
R923 T1220 T1226 arg1Of induce,[
R924 T1222 T1221 arg1Of cartilage,ectopic
R925 T1222 T1223 arg1Of cartilage,and
R926 T1223 T1220 arg2Of and,induce
R927 T1225 T1223 arg2Of formation,and
R928 T1225 T1224 arg1Of formation,bone
R929 T1227 T1226 arg2Of "2,3",[
R930 T1228 T1226 arg3Of ],[
R931 T1230 T1229 arg1Of studies,Several
R932 T1230 T1231 arg1Of studies,have
R933 T1230 T1232 arg1Of studies,demonstrated
R934 T1232 T1231 arg2Of demonstrated,have
R935 T1232 T1244 arg1Of demonstrated,recently
R936 T1232 T1245 arg1Of demonstrated,","
R937 T1232 T1247 arg1Of demonstrated,in
R938 T1235 T1232 arg2Of role,demonstrated
R939 T1235 T1233 arg1Of role,an
R940 T1235 T1234 arg1Of role,essential
R941 T1235 T1236 arg1Of role,of
R942 T1235 T1239 arg1Of role,during
R943 T1235 T1242 arg1Of role,and
R944 T1238 T1236 arg2Of proteins,of
R945 T1238 T1237 arg1Of proteins,these
R946 T1240 T1239 arg2Of embryogenesis,during
R947 T1242 T1241 arg1Of and,","
R948 T1244 T1243 arg1Of recently,more
R949 T1247 T1246 arg1Of in,also
R950 T1249 T1247 arg2Of tissues,in
R951 T1249 T1248 arg1Of tissues,adult
R952 T1249 T1250 arg1Of tissues,[
R953 T1251 T1250 arg2Of 1,[
R954 T1252 T1250 arg3Of ],[
R955 T1253 T1254 arg1Of TGF-β,has
R956 T1253 T1255 arg1Of TGF-β,been
R957 T1253 T1257 arg2Of TGF-β,studied
R958 T1253 T1265 arg1Of TGF-β,is
R959 T1257 T1254 arg2Of studied,has
R960 T1257 T1255 arg2Of studied,been
R961 T1257 T1256 arg1Of studied,intensively
R962 T1257 T1258 arg1Of studied,in
R963 T1257 T1264 arg1Of studied,and
R964 T1259 T1260 arg1Of normal,and
R965 T1261 T1260 arg2Of malignant,and
R966 T1263 T1258 arg2Of cells,in
R967 T1263 T1259 arg1Of cells,normal
R968 T1263 T1261 arg1Of cells,malignant
R969 T1263 T1262 arg1Of cells,haematopoietic
R970 T1265 T1264 arg2Of is,and
R971 T1266 T1265 arg2Of one,is
R972 T1266 T1267 arg1Of one,of
R973 T1271 T1269 arg1Of endogenous,most
R974 T1271 T1270 arg1Of endogenous,potent
R975 T1273 T1267 arg2Of regulators,of
R976 T1273 T1268 arg1Of regulators,the
R977 T1273 T1271 arg1Of regulators,endogenous
R978 T1273 T1272 arg1Of regulators,negative
R979 T1273 T1274 arg2Of regulators,known
R980 T1274 T1275 arg1Of known,to
R981 T1276 T1275 arg2Of date.,to
R982 T1276 T1277 arg1Of date.,[
R983 T1278 T1277 arg2Of 4,[
R984 T1279 T1277 arg3Of ],[
R985 T1281 T1280 arg2Of contrast,In
R986 T1284 T1283 arg1Of effect,the
R987 T1284 T1285 arg1Of effect,of
R988 T1284 T1287 arg1Of effect,in
R989 T1284 T1291 arg1Of effect,has
R990 T1284 T1293 arg1Of effect,been
R991 T1284 T1295 arg2Of effect,investigated
R992 T1286 T1285 arg2Of BMPs,of
R993 T1290 T1287 arg2Of system,in
R994 T1290 T1288 arg1Of system,the
R995 T1290 T1289 arg1Of system,immune
R996 T1295 T1280 arg1Of investigated,In
R997 T1295 T1282 arg1Of investigated,","
R998 T1295 T1291 arg2Of investigated,has
R999 T1295 T1292 arg1Of investigated,not