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PMC:1064895 / 21993-28087 JSONTXT 27 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T18418 11-16 NN denotes IL-17
T18419 17-20 VB denotes was
T18420 21-26 RB denotes first
T18421 27-36 VB denotes described
T18422 37-39 IN denotes as
T18423 40-41 DT denotes a
T18424 42-43 NN denotes T
T18425 44-48 NN denotes cell
T18426 49-56 NN denotes product
T18427 57-61 IN denotes with
T18428 62-77 JJ denotes proinflammatory
T18429 78-88 NN denotes properties
T18430 89-90 -LRB- denotes [
T18431 90-94 CD denotes 5,22
T18432 94-95 -RRB- denotes ]
T18433 97-99 NN denotes RA
T18434 100-102 VB denotes is
T18435 103-116 VB denotes characterized
T18436 117-119 IN denotes by
T18437 120-131 NN denotes hyperplasia
T18438 132-134 IN denotes of
T18439 135-143 JJ denotes synovial
T18440 144-150 JJ denotes lining
T18441 151-156 NN denotes cells
T18442 157-160 CC denotes and
T18443 161-163 DT denotes an
T18444 164-171 JJ denotes intense
T18445 172-184 NN denotes infiltration
T18446 185-187 IN denotes by
T18447 188-199 JJ denotes mononuclear
T18448 200-205 NN denotes cells
T18449 206-207 -LRB- denotes [
T18450 207-209 CD denotes 23
T18451 209-210 -RRB- denotes ]
T18452 212-227 JJ denotes Proinflammatory
T18453 228-237 NN denotes cytokines
T18454 238-242 JJ denotes such
T18455 243-245 IN denotes as
T18456 246-250 NN denotes IL-1
T18457 251-254 CC denotes and
T18458 255-260 NN denotes TNF-α
T18459 261-264 VB denotes are
T18460 265-273 JJ denotes abundant
T18461 274-276 IN denotes in
T18462 277-287 JJ denotes rheumatoid
T18463 288-296 NN denotes synovium
T18464 296-297 -COMMA- denotes ,
T18465 298-305 IN denotes whereas
T18466 306-309 DT denotes the
T18467 310-311 NN denotes T
T18468 312-324 JJ denotes cell-derived
T18469 325-334 NN denotes cytokines
T18470 334-335 -COMMA- denotes ,
T18471 336-346 RB denotes especially
T18472 347-351 NN denotes IL-4
T18473 352-355 CC denotes and
T18474 356-368 NN denotes interferon-γ
T18475 368-369 -COMMA- denotes ,
T18476 370-374 VB denotes have
T18477 375-380 RB denotes often
T18478 381-387 VB denotes proved
T18479 388-397 JJ denotes difficult
T18480 398-400 TO denotes to
T18481 401-407 VB denotes detect
T18482 408-410 IN denotes in
T18483 411-413 NN denotes RA
T18484 414-422 NN denotes synovium
T18485 423-424 -LRB- denotes [
T18486 424-426 CD denotes 24
T18487 426-427 -RRB- denotes ]
T18488 429-437 IN denotes Although
T18489 438-439 NN denotes T
T18490 440-445 NN denotes cells
T18491 446-449 MD denotes may
T18492 450-454 VB denotes have
T18493 455-456 DT denotes a
T18494 457-461 NN denotes role
T18495 462-464 IN denotes in
T18496 465-468 DT denotes the
T18497 469-481 NN denotes augmentation
T18498 482-484 IN denotes of
T18499 485-495 JJ denotes rheumatoid
T18500 496-504 JJ denotes synovial
T18501 505-517 NN denotes inflammation
T18502 517-518 -COMMA- denotes ,
T18503 519-522 DT denotes the
T18504 523-527 NN denotes lack
T18505 528-530 IN denotes of
T18506 531-532 NN denotes T
T18507 533-545 JJ denotes cell-derived
T18508 546-555 NN denotes cytokines
T18509 556-559 VB denotes has
T18510 560-567 VB denotes limited
T18511 568-571 PRP-DOLLAR- denotes its
T18512 572-582 NN denotes importance
T18513 584-586 IN denotes In
T18514 587-591 DT denotes this
T18515 592-599 NN denotes respect
T18516 599-600 -COMMA- denotes ,
T18517 601-606 NN denotes IL-17
T18518 607-609 VB denotes is
T18519 610-619 VB denotes appealing
T18520 620-627 IN denotes because
T18521 628-630 PRP denotes it
T18522 631-634 VB denotes has
T18523 635-639 VB denotes been
T18524 640-649 VB denotes described
T18525 650-652 IN denotes as
T18526 653-654 DT denotes a
T18527 655-656 NN denotes T
T18528 657-669 JJ denotes cell-derived
T18529 670-678 NN denotes cytokine
T18530 679-683 IN denotes with
T18531 684-699 JJ denotes proinflammatory
T18532 700-710 NN denotes properties
T18533 712-714 IN denotes In
T18534 715-718 PRP-DOLLAR- denotes our
T18535 719-726 NN denotes studies
T18536 726-727 -COMMA- denotes ,
T18537 728-730 PRP denotes we
T18538 731-736 VB denotes tried
T18539 737-739 TO denotes to
T18540 740-748 VB denotes evaluate
T18541 749-752 WRB denotes how
T18542 753-758 NN denotes IL-17
T18543 759-769 NN denotes production
T18544 770-772 VB denotes is
T18545 773-782 VB denotes regulated
T18546 783-785 IN denotes in
T18547 786-788 NN denotes RA
T18548 789-793 NN denotes PBMC
T18549 793-794 -COMMA- denotes ,
T18550 795-798 CC denotes and
T18551 799-804 WDT denotes which
T18552 805-814 NN denotes signaling
T18553 815-822 NN denotes pathway
T18554 823-825 PRP denotes it
T18555 826-830 VB denotes used
T18556 832-838 NN denotes Levels
T18557 839-841 IN denotes of
T18558 842-847 NN denotes IL-17
T18559 848-852 VB denotes were
T18560 853-858 VB denotes found
T18561 859-861 TO denotes to
T18562 862-864 VB denotes be
T18563 865-871 JJ denotes higher
T18564 872-874 IN denotes in
T18565 875-877 NN denotes RA
T18566 878-886 JJ denotes synovial
T18567 887-892 NN denotes fluid
T18568 893-897 IN denotes than
T18569 898-900 IN denotes in
T18570 901-903 NN denotes OA
T18571 904-912 JJ denotes synovial
T18572 913-918 NN denotes fluid
T18573 919-920 -LRB- denotes [
T18574 920-922 CD denotes 15
T18575 922-923 -RRB- denotes ]
T18576 925-932 RB denotes However
T18577 932-933 -COMMA- denotes ,
T18578 934-939 EX denotes there
T18579 940-943 VB denotes are
T18580 944-947 JJ denotes few
T18581 948-952 NN denotes data
T18582 953-962 JJ denotes available
T18583 963-965 IN denotes on
T18584 966-969 DT denotes the
T18585 970-976 NN denotes agents
T18586 977-981 WDT denotes that
T18587 982-991 VB denotes stimulate
T18588 992-997 NN denotes IL-17
T18589 998-1008 NN denotes production
T18590 1009-1011 IN denotes in
T18591 1012-1014 NN denotes RA
T18592 1014-1015 -COMMA- denotes ,
T18593 1016-1024 IN denotes although
T18594 1025-1028 DT denotes the
T18595 1029-1036 JJ denotes highest
T18596 1037-1042 NN denotes level
T18597 1043-1045 IN denotes of
T18598 1046-1051 NN denotes IL-17
T18599 1052-1062 NN denotes production
T18600 1063-1066 MD denotes can
T18601 1067-1069 VB denotes be
T18602 1070-1078 VB denotes achieved
T18603 1079-1081 IN denotes by
T18604 1082-1100 JJ denotes anti-CD3/anti-CD28
T18605 1101-1112 NN denotes stimulation
T18606 1113-1115 IN denotes in
T18607 1116-1123 JJ denotes healthy
T18608 1124-1135 NN denotes individuals
T18609 1136-1137 -LRB- denotes [
T18610 1137-1139 CD denotes 25
T18611 1139-1140 -RRB- denotes ]
T18612 1142-1144 IN denotes In
T18613 1145-1148 PRP-DOLLAR- denotes our
T18614 1149-1160 NN denotes experiments
T18615 1160-1161 -COMMA- denotes ,
T18616 1162-1165 NN denotes PHA
T18617 1166-1168 IN denotes as
T18618 1169-1177 NN denotes mitogens
T18619 1177-1178 -COMMA- denotes ,
T18620 1179-1181 RB denotes as
T18621 1182-1186 RB denotes well
T18622 1187-1189 IN denotes as
T18623 1190-1208 JJ denotes anti-CD3/anti-CD28
T18624 1209-1212 IN denotes for
T18625 1213-1222 NN denotes signaling
T18626 1223-1230 IN denotes through
T18627 1231-1234 DT denotes the
T18628 1235-1236 NN denotes T
T18629 1237-1241 NN denotes cell
T18630 1242-1250 NN denotes receptor
T18631 1250-1251 -COMMA- denotes ,
T18632 1252-1261 VB denotes increased
T18633 1262-1267 NN denotes IL-17
T18634 1268-1278 NN denotes production
T18635 1279-1283 IN denotes from
T18636 1284-1286 NN denotes RA
T18637 1287-1291 NN denotes PBMC
T18638 1292-1294 IN denotes in
T18639 1295-1296 DT denotes a
T18640 1297-1311 JJ denotes dose-dependent
T18641 1312-1318 NN denotes manner
T18642 1320-1322 PRP denotes We
T18643 1323-1328 VB denotes found
T18644 1328-1329 -COMMA- denotes ,
T18645 1330-1332 IN denotes by
T18646 1333-1334 DT denotes a
T18647 1335-1339 NN denotes cell
T18648 1340-1353 NN denotes proliferation
T18649 1354-1359 NN denotes assay
T18650 1360-1361 -LRB- denotes (
T18651 1361-1365 NN denotes data
T18652 1366-1369 RB denotes not
T18653 1370-1375 VB denotes shown
T18654 1375-1376 -RRB- denotes )
T18655 1376-1377 -COMMA- denotes ,
T18656 1378-1382 IN denotes that
T18657 1383-1387 DT denotes this
T18658 1388-1400 NN denotes upregulation
T18659 1401-1403 IN denotes of
T18660 1404-1409 NN denotes IL-17
T18661 1410-1415 MD denotes might
T18662 1416-1418 VB denotes be
T18663 1419-1422 JJ denotes due
T18664 1423-1425 TO denotes to
T18665 1426-1435 VB denotes increased
T18666 1436-1444 JJ denotes cellular
T18667 1445-1453 NN denotes activity
T18668 1454-1460 RB denotes rather
T18669 1461-1465 IN denotes than
T18670 1466-1468 TO denotes to
T18671 1469-1477 JJ denotes cellular
T18672 1478-1491 NN denotes proliferation
T18673 1493-1498 NN denotes IL-17
T18674 1499-1501 VB denotes is
T18675 1502-1510 VB denotes produced
T18676 1511-1517 RB denotes mainly
T18677 1518-1520 IN denotes by
T18678 1521-1530 VB denotes activated
T18679 1531-1535 JJ denotes CD4+
T18680 1536-1537 NN denotes T
T18681 1538-1543 NN denotes cells
T18682 1543-1544 -COMMA- denotes ,
T18683 1545-1555 RB denotes especially
T18684 1556-1559 IN denotes for
T18685 1560-1567 NN denotes Th1/Th0
T18686 1568-1573 NN denotes cells
T18687 1573-1574 -COMMA- denotes ,
T18688 1575-1578 RB denotes not
T18689 1579-1582 DT denotes the
T18690 1583-1586 NN denotes Th2
T18691 1587-1596 NN denotes phenotype
T18692 1597-1598 -LRB- denotes [
T18693 1598-1600 CD denotes 26
T18694 1600-1601 -RRB- denotes ]
T18695 1603-1610 RB denotes However
T18696 1610-1611 -COMMA- denotes ,
T18697 1612-1614 PRP denotes it
T18698 1615-1618 MD denotes can
T18699 1619-1623 RB denotes also
T18700 1624-1626 VB denotes be
T18701 1627-1635 VB denotes produced
T18702 1636-1638 IN denotes by
T18703 1639-1643 JJ denotes CD8+
T18704 1644-1645 NN denotes T
T18705 1646-1651 NN denotes cells
T18706 1652-1655 IN denotes via
T18707 1656-1658 DT denotes an
T18708 1659-1664 NN denotes IL-23
T18709 1665-1675 NN denotes triggering
T18710 1676-1685 NN denotes mechanism
T18711 1686-1688 IN denotes in
T18712 1689-1702 JJ denotes Gram-negative
T18713 1703-1712 JJ denotes pulmonary
T18714 1713-1722 NN denotes infection
T18715 1723-1724 -LRB- denotes [
T18716 1724-1726 CD denotes 14
T18717 1726-1727 -RRB- denotes ]
T18718 1729-1731 IN denotes In
T18719 1732-1740 NN denotes addition
T18720 1740-1741 -COMMA- denotes ,
T18721 1742-1747 NN denotes IL-17
T18722 1748-1758 NN denotes production
T18723 1759-1762 VB denotes was
T18724 1763-1776 RB denotes significantly
T18725 1777-1786 VB denotes augmented
T18726 1787-1789 IN denotes by
T18727 1790-1791 NN denotes T
T18728 1792-1797 NN denotes cells
T18729 1798-1809 VB denotes recognizing
T18730 1810-1814 NN denotes type
T18731 1815-1817 CD denotes II
T18732 1818-1826 NN denotes collagen
T18733 1827-1829 IN denotes in
T18734 1830-1831 DT denotes a
T18735 1832-1848 JJ denotes collagen-induced
T18736 1849-1858 NN denotes arthritis
T18737 1859-1864 NN denotes model
T18738 1865-1866 -LRB- denotes [
T18739 1866-1868 CD denotes 27
T18740 1868-1869 -RRB- denotes ]
T18741 1871-1872 DT denotes A
T18742 1873-1880 JJ denotes complex
T18743 1881-1892 NN denotes interaction
T18744 1893-1900 IN denotes between
T18745 1901-1906 NN denotes cells
T18746 1907-1909 IN denotes in
T18747 1910-1918 JJ denotes inflamed
T18748 1919-1921 NN denotes RA
T18749 1922-1928 NN denotes joints
T18750 1929-1934 MD denotes might
T18751 1935-1942 VB denotes produce
T18752 1943-1944 DT denotes a
T18753 1945-1952 NN denotes variety
T18754 1953-1955 IN denotes of
T18755 1956-1971 JJ denotes proinflammatory
T18756 1972-1981 NN denotes cytokines
T18757 1982-1985 CC denotes and
T18758 1986-1996 NN denotes chemokines
T18759 1996-1997 -COMMA- denotes ,
T18760 1998-2003 WDT denotes which
T18761 2004-2008 RB denotes also
T18762 2009-2017 VB denotes activate
T18763 2018-2023 JJ denotes other
T18764 2024-2029 NN denotes cells
T18765 2030-2032 IN denotes in
T18766 2033-2036 DT denotes the
T18767 2037-2043 NN denotes joints
T18768 2045-2048 IN denotes For
T18769 2049-2056 NN denotes example
T18770 2056-2057 -COMMA- denotes ,
T18771 2058-2063 NN denotes IL-17
T18772 2064-2074 VB denotes stimulates
T18773 2075-2085 JJ denotes rheumatoid
T18774 2086-2098 NN denotes synoviocytes
T18775 2099-2101 TO denotes to
T18776 2102-2109 VB denotes secrete
T18777 2110-2117 JJ denotes several
T18778 2118-2127 NN denotes cytokines
T18779 2128-2132 JJ denotes such
T18780 2133-2135 IN denotes as
T18781 2136-2140 NN denotes IL-6
T18782 2140-2141 -COMMA- denotes ,
T18783 2142-2146 NN denotes IL-8
T18784 2147-2150 CC denotes and
T18785 2151-2156 NN denotes tumor
T18786 2157-2165 NN denotes necrosis
T18787 2166-2183 JJ denotes factor-stimulated
T18788 2184-2188 NN denotes gene
T18789 2189-2190 CD denotes 6
T18790 2191-2193 RB denotes as
T18791 2194-2198 RB denotes well
T18792 2199-2201 IN denotes as
T18793 2202-2215 NN denotes prostaglandin
T18794 2216-2218 NN denotes E2
T18795 2219-2221 FW denotes in
T18796 2222-2227 FW denotes vitro
T18797 2228-2229 -LRB- denotes [
T18798 2229-2237 CD denotes 12,28,29
T18799 2237-2238 -RRB- denotes ]
T18800 2240-2245 EX denotes There
T18801 2246-2249 VB denotes are
T18802 2250-2252 RB denotes as
T18803 2253-2256 RB denotes yet
T18804 2257-2260 JJ denotes few
T18805 2261-2265 NN denotes data
T18806 2266-2275 JJ denotes available
T18807 2276-2278 IN denotes on
T18808 2279-2282 DT denotes the
T18809 2283-2289 NN denotes agents
T18810 2290-2294 WDT denotes that
T18811 2295-2304 VB denotes stimulate
T18812 2305-2310 NN denotes IL-17
T18813 2311-2321 NN denotes production
T18814 2322-2324 IN denotes in
T18815 2325-2327 NN denotes RA
T18816 2327-2328 -COMMA- denotes ,
T18817 2329-2337 IN denotes although
T18818 2338-2342 DT denotes some
T18819 2343-2352 NN denotes cytokines
T18820 2353-2354 -LRB- denotes (
T18821 2354-2359 NN denotes IL-15
T18822 2360-2363 CC denotes and
T18823 2364-2369 NN denotes IL-23
T18824 2369-2370 -RRB- denotes )
T18825 2371-2375 VB denotes have
T18826 2376-2380 VB denotes been
T18827 2381-2386 VB denotes known
T18828 2387-2389 TO denotes to
T18829 2390-2398 VB denotes regulate
T18830 2399-2404 NN denotes IL-17
T18831 2405-2415 NN denotes production
T18832 2416-2417 -LRB- denotes [
T18833 2417-2422 CD denotes 13,14
T18834 2422-2423 -RRB- denotes ]
T18835 2425-2427 PRP denotes We
T18836 2428-2437 RB denotes therefore
T18837 2438-2450 VB denotes investigated
T18838 2451-2454 DT denotes the
T18839 2455-2457 FW denotes in
T18840 2458-2463 FW denotes vitro
T18841 2464-2474 NN denotes production
T18842 2475-2477 IN denotes of
T18843 2478-2483 NN denotes IL-17
T18844 2484-2486 IN denotes in
T18845 2487-2489 NN denotes RA
T18846 2490-2494 NN denotes PBMC
T18847 2495-2505 VB denotes responding
T18848 2506-2508 TO denotes to
T18849 2509-2510 DT denotes a
T18850 2511-2518 NN denotes variety
T18851 2519-2521 IN denotes of
T18852 2522-2542 NN denotes cytokines/chemokines
T18853 2543-2546 CC denotes and
T18854 2547-2555 NN denotes mitogens
T18855 2556-2558 RB denotes as
T18856 2559-2563 RB denotes well
T18857 2564-2566 IN denotes as
T18858 2567-2568 NN denotes T
T18859 2569-2573 NN denotes cell
T18860 2574-2582 NN denotes receptor
T18861 2583-2584 -LRB- denotes (
T18862 2584-2587 NN denotes TCR
T18863 2587-2588 -RRB- denotes )
T18864 2589-2597 NN denotes ligation
T18865 2598-2603 VB denotes using
T18866 2604-2622 JJ denotes anti-CD3/anti-CD28
T18867 2624-2627 PRP-DOLLAR- denotes Our
T18868 2628-2635 NN denotes studies
T18869 2636-2648 VB denotes demonstrated
T18870 2649-2653 IN denotes that
T18871 2654-2659 NN denotes IL-15
T18872 2660-2663 CC denotes and
T18873 2664-2669 NN denotes MCP-1
T18874 2670-2672 RB denotes as
T18875 2673-2677 RB denotes well
T18876 2678-2680 IN denotes as
T18877 2681-2684 NN denotes TCR
T18878 2685-2693 NN denotes ligation
T18879 2694-2707 RB denotes significantly
T18880 2708-2717 VB denotes increased
T18881 2718-2721 DT denotes the
T18882 2722-2732 NN denotes production
T18883 2733-2735 IN denotes of
T18884 2736-2741 NN denotes IL-17
T18885 2742-2744 IN denotes in
T18886 2745-2747 NN denotes RA
T18887 2748-2752 NN denotes PBMC
T18888 2754-2760 VB denotes Adding
T18889 2761-2766 NN denotes IL-15
T18890 2767-2769 CC denotes or
T18891 2770-2775 NN denotes MCP-1
T18892 2776-2778 TO denotes to
T18893 2779-2782 NN denotes TCR
T18894 2783-2791 NN denotes ligation
T18895 2792-2801 VB denotes augmented
T18896 2802-2807 NN denotes IL-17
T18897 2808-2818 NN denotes production
T18898 2819-2823 RB denotes more
T18899 2824-2832 RB denotes markedly
T18900 2834-2836 IN denotes In
T18901 2837-2845 NN denotes contrast
T18902 2845-2846 -COMMA- denotes ,
T18903 2847-2851 NN denotes IL-1
T18904 2852-2855 CC denotes and
T18905 2856-2861 NN denotes TNF-α
T18906 2861-2862 -COMMA- denotes ,
T18907 2863-2868 WDT denotes which
T18908 2869-2872 VB denotes are
T18909 2873-2878 VB denotes known
T18910 2879-2881 TO denotes to
T18911 2882-2886 VB denotes have
T18912 2887-2902 JJ denotes proinflammatory
T18913 2903-2913 NN denotes properties
T18914 2914-2917 CC denotes and
T18915 2918-2920 TO denotes to
T18916 2921-2923 VB denotes be
T18917 2924-2933 VB denotes increased
T18918 2934-2936 IN denotes in
T18919 2937-2939 NN denotes RA
T18920 2940-2946 NN denotes joints
T18921 2946-2947 -COMMA- denotes ,
T18922 2948-2951 VB denotes did
T18923 2952-2955 RB denotes not
T18924 2956-2962 VB denotes affect
T18925 2963-2968 NN denotes IL-17
T18926 2969-2979 NN denotes production
T18927 2981-2984 PRP-DOLLAR- denotes Our
T18928 2985-2989 NN denotes data
T18929 2990-2994 VB denotes were
T18930 2995-3005 JJ denotes consistent
T18931 3006-3010 IN denotes with
T18932 3011-3012 DT denotes a
T18933 3013-3019 JJ denotes recent
T18934 3020-3026 NN denotes report
T18935 3027-3031 IN denotes that
T18936 3032-3037 NN denotes IL-15
T18937 3038-3047 VB denotes triggered
T18938 3048-3050 FW denotes in
T18939 3051-3056 FW denotes vitro
T18940 3057-3062 NN denotes IL-17
T18941 3063-3073 NN denotes production
T18942 3074-3076 IN denotes in
T18943 3077-3081 NN denotes PBMC
T18944 3081-3082 -COMMA- denotes ,
T18945 3083-3086 CC denotes but
T18946 3087-3092 NN denotes TNF-α
T18947 3093-3096 VB denotes did
T18948 3097-3100 RB denotes not
T18949 3101-3103 VB denotes do
T18950 3104-3106 RB denotes so
T18951 3107-3108 -LRB- denotes [
T18952 3108-3110 CD denotes 13
T18953 3110-3111 -RRB- denotes ]
T18954 3113-3121 IN denotes Although
T18955 3122-3127 EX denotes there
T18956 3128-3132 VB denotes were
T18957 3133-3135 DT denotes no
T18958 3136-3140 NN denotes data
T18959 3141-3145 IN denotes that
T18960 3146-3151 NN denotes MCP-1
T18961 3152-3160 RB denotes directly
T18962 3161-3168 VB denotes induces
T18963 3169-3170 NN denotes T
T18964 3171-3175 NN denotes cell
T18965 3176-3186 NN denotes activation
T18966 3186-3187 -COMMA- denotes ,
T18967 3188-3190 PRP denotes it
T18968 3191-3196 MD denotes might
T18969 3197-3202 VB denotes exert
T18970 3203-3210 NN denotes effects
T18971 3211-3221 RB denotes indirectly
T18972 3222-3224 IN denotes on
T18973 3225-3226 NN denotes T
T18974 3227-3232 NN denotes cells
T18975 3233-3240 IN denotes through
T18976 3241-3244 DT denotes the
T18977 3245-3255 NN denotes activation
T18978 3256-3258 IN denotes of
T18979 3259-3280 NN denotes monocytes/macrophages
T18980 3281-3283 IN denotes in
T18981 3284-3288 NN denotes PBMC
T18982 3289-3297 NN denotes cultures
T18983 3299-3301 IN denotes As
T18984 3302-3310 VB denotes reported
T18985 3311-3314 IN denotes for
T18986 3315-3321 JJ denotes normal
T18987 3322-3333 NN denotes individuals
T18988 3334-3335 -LRB- denotes [
T18989 3335-3337 CD denotes 25
T18990 3337-3338 -RRB- denotes ]
T18991 3338-3339 -COMMA- denotes ,
T18992 3340-3341 NN denotes T
T18993 3342-3346 NN denotes cell
T18994 3347-3357 NN denotes activation
T18995 3358-3365 IN denotes through
T18996 3366-3384 JJ denotes anti-CD3/anti-CD28
T18997 3385-3389 RB denotes also
T18998 3390-3399 VB denotes increases
T18999 3400-3405 NN denotes IL-17
T19000 3406-3415 NN denotes induction
T19001 3416-3418 IN denotes in
T19002 3419-3421 NN denotes RA
T19003 3422-3426 NN denotes PBMC
T19004 3428-3436 IN denotes Although
T19005 3437-3440 DT denotes the
T19006 3441-3450 NN denotes signaling
T19007 3451-3458 NN denotes pathway
T19008 3459-3462 IN denotes for
T19009 3463-3466 DT denotes the
T19010 3467-3476 NN denotes induction
T19011 3477-3479 IN denotes of
T19012 3480-3500 NN denotes cytokines/chemokines
T19013 3501-3503 IN denotes by
T19014 3504-3509 NN denotes IL-17
T19015 3510-3513 VB denotes has
T19016 3514-3518 VB denotes been
T19017 3519-3529 VB denotes documented
T19018 3530-3536 RB denotes widely
T19019 3537-3538 -LRB- denotes [
T19020 3538-3545 CD denotes 8,30,31
T19021 3545-3546 -RRB- denotes ]
T19022 3546-3547 -COMMA- denotes ,
T19023 3548-3550 DT denotes no
T19024 3551-3555 NN denotes data
T19025 3556-3560 VB denotes have
T19026 3561-3565 VB denotes been
T19027 3566-3575 JJ denotes available
T19028 3576-3578 IN denotes on
T19029 3579-3582 WRB denotes how
T19030 3583-3588 NN denotes IL-17
T19031 3589-3599 NN denotes production
T19032 3600-3603 MD denotes can
T19033 3604-3606 VB denotes be
T19034 3607-3616 VB denotes regulated
T19035 3617-3619 IN denotes by
T19036 3620-3627 JJ denotes certain
T19037 3628-3637 NN denotes signaling
T19038 3638-3646 NN denotes pathways
T19039 3648-3650 IN denotes By
T19040 3651-3656 VB denotes using
T19041 3657-3663 NN denotes signal
T19042 3664-3676 NN denotes transduction
T19043 3677-3687 NN denotes inhibitors
T19044 3687-3688 -COMMA- denotes ,
T19045 3689-3691 PRP denotes we
T19046 3692-3701 RB denotes therefore
T19047 3702-3710 VB denotes examined
T19048 3711-3716 WDT denotes which
T19049 3717-3726 NN denotes signaling
T19050 3727-3734 NN denotes pathway
T19051 3735-3738 VB denotes was
T19052 3739-3745 RB denotes mainly
T19053 3746-3754 VB denotes involved
T19054 3755-3757 IN denotes in
T19055 3758-3761 DT denotes the
T19056 3762-3771 NN denotes induction
T19057 3772-3774 IN denotes of
T19058 3775-3780 NN denotes IL-17
T19059 3781-3783 IN denotes in
T19060 3784-3786 NN denotes RA
T19061 3787-3791 NN denotes PBMC
T19062 3793-3795 PRP denotes We
T19063 3796-3806 VB denotes identified
T19064 3807-3811 IN denotes that
T19065 3812-3828 JJ denotes anti-CD3-induced
T19066 3829-3834 NN denotes IL-17
T19067 3835-3845 NN denotes production
T19068 3846-3848 IN denotes in
T19069 3849-3851 NN denotes RA
T19070 3852-3856 NN denotes PBMC
T19071 3857-3860 VB denotes was
T19072 3861-3874 RB denotes significantly
T19073 3875-3883 VB denotes hampered
T19074 3884-3886 IN denotes by
T19075 3887-3890 DT denotes the
T19076 3891-3895 NN denotes PI3K
T19077 3896-3905 NN denotes inhibitor
T19078 3906-3914 NN denotes LY294002
T19079 3915-3918 CC denotes and
T19080 3919-3922 DT denotes the
T19081 3923-3928 NN denotes NF-κB
T19082 3929-3938 NN denotes inhibitor
T19083 3939-3943 NN denotes PDTC
T19084 3944-3946 TO denotes to
T19085 3947-3957 JJ denotes comparable
T19086 3958-3964 NN denotes levels
T19087 3965-3967 IN denotes of
T19088 3968-3973 JJ denotes basal
T19089 3974-3984 NN denotes production
T19090 3985-3992 IN denotes without
T19091 3993-4004 NN denotes stimulation
T19092 4006-4008 PRP denotes We
T19093 4009-4013 RB denotes also
T19094 4014-4019 VB denotes found
T19095 4020-4024 IN denotes that
T19096 4025-4041 JJ denotes anti-CD3-induced
T19097 4042-4047 NN denotes IL-17
T19098 4048-4058 NN denotes production
T19099 4059-4062 VB denotes was
T19100 4063-4076 VB denotes downregulated
T19101 4077-4079 IN denotes by
T19102 4080-4083 DT denotes the
T19103 4084-4092 NN denotes addition
T19104 4093-4095 IN denotes of
T19105 4096-4104 NN denotes SB203580
T19106 4104-4105 -COMMA- denotes ,
T19107 4106-4107 DT denotes a
T19108 4108-4111 NN denotes p38
T19109 4112-4116 NN denotes MAPK
T19110 4117-4126 NN denotes inhibitor
T19111 4128-4130 PRP denotes It
T19112 4131-4133 VB denotes is
T19113 4134-4145 JJ denotes interesting
T19114 4146-4150 IN denotes that
T19115 4151-4152 DT denotes a
T19116 4153-4159 NN denotes series
T19117 4160-4162 IN denotes of
T19118 4163-4171 NN denotes evidence
T19119 4172-4180 VB denotes supports
T19120 4181-4190 NN denotes crosstalk
T19121 4191-4198 IN denotes between
T19122 4199-4204 NN denotes NF-κB
T19123 4205-4208 CC denotes and
T19124 4209-4212 NN denotes p38
T19125 4214-4216 IN denotes In
T19126 4217-4225 NN denotes myocytes
T19127 4225-4226 -COMMA- denotes ,
T19128 4227-4230 NN denotes IκB
T19129 4231-4239 NN denotes kinase-β
T19130 4240-4242 VB denotes is
T19131 4243-4252 VB denotes activated
T19132 4253-4255 IN denotes by
T19133 4256-4259 NN denotes p38
T19134 4260-4261 -LRB- denotes [
T19135 4261-4263 CD denotes 32
T19136 4263-4264 -RRB- denotes ]
T19137 4264-4265 -COMMA- denotes ,
T19138 4266-4269 CC denotes and
T19139 4270-4273 DT denotes the
T19140 4274-4283 VB denotes activated
T19141 4284-4287 NN denotes p38
T19142 4288-4291 MD denotes can
T19143 4292-4301 VB denotes stimulate
T19144 4302-4307 NN denotes NF-κB
T19145 4308-4310 IN denotes by
T19146 4311-4312 DT denotes a
T19147 4313-4322 NN denotes mechanism
T19148 4323-4332 VB denotes involving
T19149 4333-4340 NN denotes histone
T19150 4341-4350 NN denotes acetylase
T19151 4351-4368 JJ denotes p300/CREB-binding
T19152 4369-4376 NN denotes protein
T19153 4377-4378 -LRB- denotes [
T19154 4378-4380 CD denotes 33
T19155 4380-4381 -RRB- denotes ]
T19156 4383-4386 PRP-DOLLAR- denotes Our
T19157 4387-4394 NN denotes results
T19158 4395-4403 VB denotes revealed
T19159 4404-4408 IN denotes that
T19160 4409-4412 NN denotes p38
T19161 4413-4417 NN denotes MAPK
T19162 4418-4428 NN denotes activation
T19163 4429-4432 VB denotes was
T19164 4433-4436 RB denotes not
T19165 4437-4445 VB denotes affected
T19166 4446-4448 IN denotes by
T19167 4449-4457 NN denotes LY294002
T19168 4457-4458 -COMMA- denotes ,
T19169 4459-4466 IN denotes whereas
T19170 4467-4472 NN denotes NF-κB
T19171 4473-4480 NN denotes binding
T19172 4481-4489 NN denotes activity
T19173 4490-4493 VB denotes was
T19174 4494-4503 VB denotes decreased
T19175 4504-4506 IN denotes by
T19176 4507-4515 NN denotes LY294002
T19177 4515-4516 -COMMA- denotes ,
T19178 4517-4522 WDT denotes which
T19179 4523-4531 VB denotes provided
T19180 4532-4535 DT denotes the
T19181 4536-4544 NN denotes evidence
T19182 4545-4548 IN denotes for
T19183 4549-4550 DT denotes a
T19184 4551-4554 NN denotes p38
T19185 4555-4559 NN denotes MAPK
T19186 4560-4567 NN denotes pathway
T19187 4568-4579 JJ denotes independent
T19188 4580-4582 IN denotes of
T19189 4583-4587 NN denotes PI3K
T19190 4588-4598 NN denotes activation
T19191 4600-4603 DT denotes The
T19192 4604-4610 JJ denotes direct
T19193 4611-4623 NN denotes relationship
T19194 4624-4631 IN denotes between
T19195 4632-4635 NN denotes p38
T19196 4636-4639 CC denotes and
T19197 4640-4645 NN denotes NF-κB
T19198 4646-4649 IN denotes for
T19199 4650-4655 NN denotes IL-17
T19200 4656-4666 NN denotes production
T19201 4667-4672 VB denotes needs
T19202 4673-4675 TO denotes to
T19203 4676-4678 VB denotes be
T19204 4679-4686 VB denotes studied
T19205 4687-4689 IN denotes in
T19206 4690-4696 JJ denotes future
T19207 4697-4708 NN denotes experiments
T19208 4710-4713 DT denotes The
T19209 4714-4720 NN denotes search
T19210 4721-4724 IN denotes for
T19211 4725-4726 DT denotes a
T19212 4727-4737 JJ denotes downstream
T19213 4738-4745 NN denotes pathway
T19214 4746-4748 IN denotes of
T19215 4749-4753 NN denotes PI3K
T19216 4754-4760 VB denotes seemed
T19217 4761-4763 TO denotes to
T19218 4764-4768 VB denotes have
T19219 4769-4770 DT denotes a
T19220 4771-4778 JJ denotes maximal
T19221 4779-4787 NN denotes response
T19222 4788-4790 IN denotes of
T19223 4791-4794 NN denotes Akt
T19224 4795-4805 NN denotes activation
T19225 4806-4808 IN denotes at
T19226 4809-4810 CD denotes 1
T19227 4811-4815 NN denotes hour
T19228 4816-4819 CC denotes and
T19229 4820-4821 DT denotes a
T19230 4822-4829 JJ denotes gradual
T19231 4830-4834 NN denotes loss
T19232 4835-4837 IN denotes of
T19233 4838-4846 NN denotes activity
T19234 4847-4849 IN denotes at
T19235 4850-4851 CD denotes 2
T19236 4852-4857 NN denotes hours
T19237 4859-4862 DT denotes The
T19238 4863-4867 NN denotes fact
T19239 4868-4872 IN denotes that
T19240 4873-4876 NN denotes Akt
T19241 4877-4879 VB denotes is
T19242 4880-4894 VB denotes phosphorylated
T19243 4895-4899 IN denotes upon
T19244 4900-4908 JJ denotes anti-CD3
T19245 4909-4920 NN denotes stimulation
T19246 4921-4929 VB denotes suggests
T19247 4930-4933 DT denotes the
T19248 4934-4942 JJ denotes possible
T19249 4943-4954 NN denotes involvement
T19250 4955-4957 IN denotes of
T19251 4958-4962 NN denotes PI3K
T19252 4963-4965 IN denotes in
T19253 4966-4969 DT denotes the
T19254 4970-4979 NN denotes induction
T19255 4980-4982 IN denotes of
T19256 4983-4988 NN denotes IL-17
T19257 4989-4991 IN denotes in
T19258 4992-4994 NN denotes RA
T19259 4996-4998 IN denotes In
T19260 4999-5003 NN denotes view
T19261 5004-5006 IN denotes of
T19262 5007-5010 DT denotes the
T19263 5011-5015 NN denotes fact
T19264 5016-5020 IN denotes that
T19265 5021-5026 NN denotes NF-κB
T19266 5027-5030 VB denotes was
T19267 5031-5035 RB denotes also
T19268 5036-5045 VB denotes activated
T19269 5046-5048 IN denotes by
T19270 5049-5067 JJ denotes anti-CD3/anti-CD28
T19271 5067-5068 -COMMA- denotes ,
T19272 5069-5074 NN denotes IL-15
T19273 5075-5077 CC denotes or
T19274 5078-5086 NN denotes mitogens
T19275 5087-5089 IN denotes in
T19276 5090-5093 PRP-DOLLAR- denotes our
T19277 5094-5105 NN denotes experiments
T19278 5105-5106 -COMMA- denotes ,
T19279 5107-5109 PRP denotes it
T19280 5110-5112 VB denotes is
T19281 5113-5117 RB denotes most
T19282 5118-5124 JJ denotes likely
T19283 5125-5129 IN denotes that
T19284 5130-5133 DT denotes the
T19285 5134-5139 NN denotes NF-κB
T19286 5140-5147 NN denotes pathway
T19287 5148-5150 VB denotes is
T19288 5151-5155 RB denotes also
T19289 5156-5164 RB denotes actively
T19290 5165-5173 VB denotes involved
T19291 5174-5176 IN denotes in
T19292 5177-5180 DT denotes the
T19293 5181-5190 NN denotes induction
T19294 5191-5193 IN denotes of
T19295 5194-5199 NN denotes IL-17
T19296 5200-5202 IN denotes in
T19297 5203-5205 NN denotes RA
T19298 5206-5210 NN denotes PBMC
T19299 5212-5214 IN denotes In
T19300 5215-5223 NN denotes contrast
T19301 5223-5224 -COMMA- denotes ,
T19302 5225-5228 DT denotes the
T19303 5229-5233 NN denotes AP-1
T19304 5234-5240 NN denotes signal
T19305 5241-5253 NN denotes transduction
T19306 5254-5261 NN denotes pathway
T19307 5261-5262 -COMMA- denotes ,
T19308 5263-5270 DT denotes another
T19309 5271-5280 JJ denotes important
T19310 5281-5290 NN denotes signaling
T19311 5291-5298 NN denotes pathway
T19312 5299-5302 IN denotes for
T19313 5303-5323 NN denotes cytokines/chemokines
T19314 5323-5324 -COMMA- denotes ,
T19315 5325-5328 VB denotes was
T19316 5329-5332 RB denotes not
T19317 5333-5342 VB denotes activated
T19318 5343-5345 IN denotes in
T19319 5346-5349 PRP-DOLLAR- denotes our
T19320 5350-5361 NN denotes experiments
T19321 5362-5363 -LRB- denotes (
T19322 5363-5367 NN denotes data
T19323 5368-5371 RB denotes not
T19324 5372-5377 VB denotes shown
T19325 5377-5378 -RRB- denotes )
T19326 5380-5388 IN denotes Although
T19327 5389-5393 NN denotes PI3K
T19328 5394-5397 CC denotes and
T19329 5398-5401 PRP-DOLLAR- denotes its
T19330 5402-5412 JJ denotes downstream
T19331 5413-5419 NN denotes kinase
T19332 5420-5423 NN denotes Akt
T19333 5424-5426 IN denotes in
T19334 5427-5438 NN denotes association
T19335 5439-5443 IN denotes with
T19336 5444-5449 NN denotes NF-κB
T19337 5450-5454 VB denotes have
T19338 5455-5459 VB denotes been
T19339 5460-5468 VB denotes reported
T19340 5469-5471 TO denotes to
T19341 5472-5479 VB denotes deliver
T19342 5480-5490 VB denotes activating
T19343 5491-5498 NN denotes signals
T19344 5499-5501 IN denotes in
T19345 5502-5506 JJ denotes many
T19346 5507-5511 NN denotes cell
T19347 5512-5517 NN denotes types
T19348 5517-5518 -COMMA- denotes ,
T19349 5519-5522 DT denotes the
T19350 5523-5527 NN denotes data
T19351 5528-5530 IN denotes on
T19352 5531-5534 DT denotes the
T19353 5535-5541 NN denotes signal
T19354 5542-5550 VB denotes inducing
T19355 5551-5556 NN denotes IL-17
T19356 5557-5560 VB denotes are
T19357 5561-5568 VB denotes lacking
T19358 5570-5573 PRP-DOLLAR- denotes Our
T19359 5574-5578 NN denotes data
T19360 5579-5586 RB denotes clearly
T19361 5587-5599 VB denotes demonstrated
T19362 5600-5604 IN denotes that
T19363 5605-5613 NN denotes PI3K/Akt
T19364 5614-5617 CC denotes and
T19365 5618-5627 JJ denotes resultant
T19366 5628-5633 NN denotes NF-κB
T19367 5634-5644 NN denotes activation
T19368 5645-5650 MD denotes could
T19369 5651-5653 VB denotes be
T19370 5654-5656 DT denotes an
T19371 5657-5666 JJ denotes important
T19372 5667-5677 NN denotes arbitrator
T19373 5678-5680 IN denotes of
T19374 5681-5684 DT denotes the
T19375 5685-5697 NN denotes upregulation
T19376 5698-5700 IN denotes of
T19377 5701-5706 NN denotes IL-17
T19378 5707-5709 IN denotes in
T19379 5710-5712 NN denotes RA
T19380 5712-5713 -COMMA- denotes ,
T19381 5714-5716 IN denotes on
T19382 5717-5720 DT denotes the
T19383 5721-5726 NN denotes basis
T19384 5727-5729 IN denotes of
T19385 5730-5733 PRP-DOLLAR- denotes our
T19386 5734-5745 NN denotes experiments
T19387 5746-5753 VB denotes showing
T19388 5754-5766 JJ denotes simultaneous
T19389 5767-5775 NN denotes blocking
T19390 5776-5778 IN denotes of
T19391 5779-5784 NN denotes NF-κB
T19392 5785-5792 NN denotes binding
T19393 5793-5801 NN denotes activity
T19394 5802-5804 IN denotes in
T19395 5805-5808 DT denotes the
T19396 5809-5814 NN denotes IL-17
T19397 5815-5823 NN denotes promoter
T19398 5824-5826 IN denotes by
T19399 5827-5831 NN denotes PDTC
T19400 5832-5835 CC denotes and
T19401 5836-5844 NN denotes LY294002
T19402 5846-5857 VB denotes Considering
T19403 5858-5861 PRP-DOLLAR- denotes its
T19404 5862-5877 JJ denotes proinflammatory
T19405 5878-5888 NN denotes activities
T19406 5889-5892 CC denotes and
T19407 5893-5903 JJ denotes successful
T19408 5904-5913 NN denotes induction
T19409 5914-5916 IN denotes of
T19410 5917-5927 NN denotes anti-IL-17
T19411 5928-5931 IN denotes for
T19412 5932-5944 VB denotes ameliorating
T19413 5945-5954 NN denotes arthritis
T19414 5955-5957 IN denotes in
T19415 5958-5964 NN denotes animal
T19416 5965-5971 NN denotes models
T19417 5972-5973 -LRB- denotes [
T19418 5973-5982 CD denotes 2,6,34-36
T19419 5982-5983 -RRB- denotes ]
T19420 5983-5984 -COMMA- denotes ,
T19421 5985-5998 VB denotes understanding
T19422 5999-6002 DT denotes the
T19423 6003-6008 NN denotes IL-17
T19424 6009-6018 NN denotes signaling
T19425 6019-6026 NN denotes pathway
T19426 6027-6029 VB denotes is
T19427 6030-6032 DT denotes an
T19428 6033-6042 JJ denotes important
T19429 6043-6050 NN denotes element
T19430 6051-6053 IN denotes of
T19431 6054-6064 VB denotes developing
T19432 6065-6068 JJ denotes new
T19433 6069-6077 VB denotes targeted
T19434 6078-6087 NN denotes therapies
T19435 6088-6090 IN denotes in
T19436 6091-6093 NN denotes RA
R10000 T18977 T18978 arg1Of activation,of
R10001 T18977 T18980 arg1Of activation,in
R10002 T18979 T18978 arg2Of monocytes/macrophages,of
R10003 T18982 T18980 arg2Of cultures,in
R10004 T18982 T18981 arg1Of cultures,PBMC
R10005 T18984 T18983 arg2Of reported,As
R10006 T18984 T18985 arg1Of reported,for
R10007 T18987 T18985 arg2Of individuals,for
R10008 T18987 T18986 arg1Of individuals,normal
R10009 T18987 T18988 arg1Of individuals,[
R10010 T18989 T18988 arg2Of 25,[
R10011 T18990 T18988 arg3Of ],[
R10012 T18994 T18992 arg1Of activation,T
R10013 T18994 T18993 arg1Of activation,cell
R10014 T18994 T18995 arg1Of activation,through
R10015 T18994 T18998 arg1Of activation,increases
R10016 T18996 T18995 arg2Of anti-CD3/anti-CD28,through
R10017 T18998 T18983 arg1Of increases,As
R10018 T18998 T18991 arg1Of increases,","
R10019 T18998 T18997 arg1Of increases,also
R10020 T19000 T18998 arg2Of induction,increases
R10021 T19000 T18999 arg1Of induction,IL-17
R10022 T19000 T19001 arg1Of induction,in
R10023 T19003 T19001 arg2Of PBMC,in
R10024 T19003 T19002 arg1Of PBMC,RA
R10025 T19007 T19005 arg1Of pathway,the
R10026 T19007 T19006 arg1Of pathway,signaling
R10027 T19007 T19008 arg1Of pathway,for
R10028 T19007 T19015 arg1Of pathway,has
R10029 T19007 T19016 arg1Of pathway,been
R10030 T19007 T19017 arg2Of pathway,documented
R10031 T19010 T19008 arg2Of induction,for
R10032 T19010 T19009 arg1Of induction,the
R10033 T19010 T19011 arg1Of induction,of
R10034 T19010 T19013 arg1Of induction,by
R10035 T19012 T19011 arg2Of cytokines/chemokines,of
R10036 T19014 T19013 arg2Of IL-17,by
R10037 T19017 T19004 arg2Of documented,Although
R10038 T19017 T19015 arg2Of documented,has
R10039 T19017 T19016 arg2Of documented,been
R10040 T19017 T19018 arg1Of documented,widely
R10041 T19017 T19019 arg1Of documented,[
R10042 T19020 T19019 arg2Of "8,30,31",[
R10043 T19021 T19019 arg3Of ],[
R10044 T19024 T19023 arg1Of data,no
R10045 T19024 T19025 arg1Of data,have
R10046 T19024 T19026 arg1Of data,been
R10047 T19024 T19027 arg1Of data,available
R10048 T19026 T19004 arg1Of been,Although
R10049 T19026 T19022 arg1Of been,","
R10050 T19026 T19025 arg2Of been,have
R10051 T19027 T19026 arg2Of available,been
R10052 T19027 T19028 arg1Of available,on
R10053 T19029 T19028 arg2Of how,on
R10054 T19031 T19030 arg1Of production,IL-17
R10055 T19031 T19032 arg1Of production,can
R10056 T19031 T19033 arg1Of production,be
R10057 T19031 T19034 arg2Of production,regulated
R10058 T19034 T19029 arg1Of regulated,how
R10059 T19034 T19032 arg2Of regulated,can
R10060 T19034 T19033 arg2Of regulated,be
R10061 T19038 T19034 arg1Of pathways,regulated
R10062 T19038 T19035 arg2Of pathways,by
R10063 T19038 T19036 arg1Of pathways,certain
R10064 T19038 T19037 arg1Of pathways,signaling
R10065 T19040 T19039 arg2Of using,By
R10066 T19043 T19040 arg2Of inhibitors,using
R10067 T19043 T19041 arg1Of inhibitors,signal
R10068 T19043 T19042 arg1Of inhibitors,transduction
R10069 T19045 T19040 arg1Of we,using
R10070 T19045 T19047 arg1Of we,examined
R10071 T19047 T19039 arg1Of examined,By
R10072 T19047 T19044 arg1Of examined,","
R10073 T19047 T19046 arg1Of examined,therefore
R10074 T19048 T19047 arg2Of which,examined
R10075 T19050 T19048 arg1Of pathway,which
R10076 T19050 T19049 arg1Of pathway,signaling
R10077 T19050 T19051 arg1Of pathway,was
R10078 T19050 T19053 arg2Of pathway,involved
R10079 T19053 T19051 arg2Of involved,was
R10080 T19053 T19052 arg1Of involved,mainly
R10081 T19053 T19054 arg1Of involved,in
R10082 T19056 T19054 arg2Of induction,in
R10083 T19056 T19055 arg1Of induction,the
R10084 T19056 T19057 arg1Of induction,of
R10085 T19056 T19059 arg1Of induction,in
R10086 T19058 T19057 arg2Of IL-17,of
R10087 T19061 T19059 arg2Of PBMC,in
R10088 T19061 T19060 arg1Of PBMC,RA
R10089 T19062 T19063 arg1Of We,identified
R10090 T19067 T19065 arg1Of production,anti-CD3-induced
R10091 T19067 T19066 arg1Of production,IL-17
R10092 T19067 T19068 arg1Of production,in
R10093 T19067 T19071 arg1Of production,was
R10094 T19067 T19073 arg2Of production,hampered
R10095 T19070 T19068 arg2Of PBMC,in
R10096 T19070 T19069 arg1Of PBMC,RA
R10097 T19073 T19063 arg2Of hampered,identified
R10098 T19073 T19064 arg1Of hampered,that
R10099 T19073 T19071 arg2Of hampered,was
R10100 T19073 T19072 arg1Of hampered,significantly
R10101 T19077 T19075 arg1Of inhibitor,the
R10102 T19077 T19076 arg1Of inhibitor,PI3K
R10103 T19078 T19077 arg1Of LY294002,inhibitor
R10104 T19078 T19079 arg1Of LY294002,and
R10105 T19079 T19073 arg1Of and,hampered
R10106 T19079 T19074 arg2Of and,by
R10107 T19079 T19084 arg1Of and,to
R10108 T19082 T19080 arg1Of inhibitor,the
R10109 T19082 T19081 arg1Of inhibitor,NF-κB
R10110 T19083 T19079 arg2Of PDTC,and
R10111 T19083 T19082 arg1Of PDTC,inhibitor
R10112 T19086 T19084 arg2Of levels,to
R10113 T19086 T19085 arg1Of levels,comparable
R10114 T19086 T19087 arg1Of levels,of
R10115 T19089 T19087 arg2Of production,of
R10116 T19089 T19088 arg1Of production,basal
R10117 T19089 T19090 arg1Of production,without
R10118 T19091 T19090 arg2Of stimulation,without
R10119 T19092 T19094 arg1Of We,found
R10120 T19094 T19093 arg1Of found,also
R10121 T19098 T19096 arg1Of production,anti-CD3-induced
R10122 T19098 T19097 arg1Of production,IL-17
R10123 T19098 T19099 arg1Of production,was
R10124 T19098 T19100 arg2Of production,downregulated
R10125 T19100 T19094 arg2Of downregulated,found
R10126 T19100 T19095 arg1Of downregulated,that
R10127 T19100 T19099 arg2Of downregulated,was
R10128 T19103 T19100 arg1Of addition,downregulated
R10129 T19103 T19101 arg2Of addition,by
R10130 T19103 T19102 arg1Of addition,the
R10131 T19103 T19104 arg1Of addition,of
R10132 T19105 T19104 arg2Of SB203580,of
R10133 T19105 T19106 arg1Of SB203580,","
R10134 T19110 T19106 arg2Of inhibitor,","
R10135 T19110 T19107 arg1Of inhibitor,a
R10136 T19110 T19108 arg1Of inhibitor,p38
R10137 T19110 T19109 arg1Of inhibitor,MAPK
R10138 T19113 T19112 arg2Of interesting,is
R10139 T19116 T19115 arg1Of series,a
R10140 T19116 T19117 arg1Of series,of
R10141 T19116 T19119 arg1Of series,supports
R10142 T19118 T19117 arg2Of evidence,of
R10143 T19119 T19111 arg1Of supports,It
R10144 T19119 T19112 arg1Of supports,is
R10145 T19119 T19113 arg1Of supports,interesting
R10146 T19119 T19114 arg1Of supports,that
R10147 T19120 T19119 arg2Of crosstalk,supports
R10148 T19120 T19121 arg1Of crosstalk,between
R10149 T19122 T19123 arg1Of NF-κB,and
R10150 T19123 T19121 arg2Of and,between
R10151 T19124 T19123 arg2Of p38,and
R10152 T19126 T19125 arg2Of myocytes,In
R10153 T19129 T19128 arg1Of kinase-β,IκB
R10154 T19129 T19130 arg1Of kinase-β,is
R10155 T19129 T19131 arg2Of kinase-β,activated
R10156 T19131 T19130 arg2Of activated,is
R10157 T19131 T19134 arg1Of activated,[
R10158 T19131 T19138 arg1Of activated,and
R10159 T19133 T19131 arg1Of p38,activated
R10160 T19133 T19132 arg2Of p38,by
R10161 T19135 T19134 arg2Of 32,[
R10162 T19136 T19134 arg3Of ],[
R10163 T19138 T19125 arg1Of and,In
R10164 T19138 T19127 arg1Of and,","
R10165 T19138 T19137 arg1Of and,","
R10166 T19141 T19139 arg1Of p38,the
R10167 T19141 T19140 arg2Of p38,activated
R10168 T19141 T19142 arg1Of p38,can
R10169 T19141 T19143 arg1Of p38,stimulate
R10170 T19143 T19138 arg2Of stimulate,and
R10171 T19143 T19142 arg2Of stimulate,can
R10172 T19143 T19145 arg1Of stimulate,by
R10173 T19144 T19143 arg2Of NF-κB,stimulate
R10174 T19147 T19145 arg2Of mechanism,by
R10175 T19147 T19146 arg1Of mechanism,a
R10176 T19147 T19148 arg1Of mechanism,involving
R10177 T19152 T19148 arg2Of protein,involving
R10178 T19152 T19149 arg1Of protein,histone
R10179 T19152 T19150 arg1Of protein,acetylase
R10180 T19152 T19151 arg1Of protein,p300/CREB-binding
R10181 T19152 T19153 arg1Of protein,[
R10182 T19154 T19153 arg2Of 33,[
R10183 T19155 T19153 arg3Of ],[
R10184 T19157 T19156 arg1Of results,Our
R10185 T19157 T19158 arg1Of results,revealed
R10186 T19162 T19160 arg1Of activation,p38
R10187 T19162 T19161 arg1Of activation,MAPK
R10188 T19162 T19163 arg1Of activation,was
R10189 T19162 T19165 arg2Of activation,affected
R10190 T19165 T19158 arg2Of affected,revealed
R10191 T19165 T19159 arg1Of affected,that
R10192 T19165 T19163 arg2Of affected,was
R10193 T19165 T19164 arg1Of affected,not
R10194 T19165 T19168 arg1Of affected,","
R10195 T19165 T19169 arg1Of affected,whereas
R10196 T19165 T19177 arg1Of affected,","
R10197 T19165 T19178 arg1Of affected,which
R10198 T19165 T19179 arg1Of affected,provided
R10199 T19167 T19165 arg1Of LY294002,affected
R10200 T19167 T19166 arg2Of LY294002,by
R10201 T19172 T19170 arg1Of activity,NF-κB
R10202 T19172 T19171 arg1Of activity,binding
R10203 T19172 T19173 arg1Of activity,was
R10204 T19172 T19174 arg2Of activity,decreased
R10205 T19174 T19169 arg2Of decreased,whereas
R10206 T19174 T19173 arg2Of decreased,was
R10207 T19176 T19174 arg1Of LY294002,decreased
R10208 T19176 T19175 arg2Of LY294002,by
R10209 T19181 T19179 arg2Of evidence,provided
R10210 T19181 T19180 arg1Of evidence,the
R10211 T19181 T19182 arg1Of evidence,for
R10212 T19186 T19182 arg2Of pathway,for
R10213 T19186 T19183 arg1Of pathway,a
R10214 T19186 T19184 arg1Of pathway,p38
R10215 T19186 T19185 arg1Of pathway,MAPK
R10216 T19186 T19187 arg1Of pathway,independent
R10217 T19187 T19188 arg1Of independent,of
R10218 T19190 T19188 arg2Of activation,of
R10219 T19190 T19189 arg1Of activation,PI3K
R10220 T19193 T19191 arg1Of relationship,The
R10221 T19193 T19192 arg1Of relationship,direct
R10222 T19193 T19194 arg1Of relationship,between
R10223 T19193 T19201 arg1Of relationship,needs
R10224 T19193 T19203 arg1Of relationship,be
R10225 T19193 T19204 arg2Of relationship,studied
R10226 T19195 T19196 arg1Of p38,and
R10227 T19196 T19194 arg2Of and,between
R10228 T19196 T19198 arg1Of and,for
R10229 T19197 T19196 arg2Of NF-κB,and
R10230 T19200 T19198 arg2Of production,for
R10231 T19200 T19199 arg1Of production,IL-17
R10232 T19204 T19201 arg2Of studied,needs
R10233 T19204 T19202 arg1Of studied,to
R10234 T19204 T19203 arg2Of studied,be
R10235 T19204 T19205 arg1Of studied,in
R10236 T19207 T19205 arg2Of experiments,in
R10237 T19207 T19206 arg1Of experiments,future
R10238 T19209 T19208 arg1Of search,The
R10239 T19209 T19210 arg1Of search,for
R10240 T19209 T19216 arg1Of search,seemed
R10241 T19209 T19218 arg1Of search,have
R10242 T19213 T19210 arg2Of pathway,for
R10243 T19213 T19211 arg1Of pathway,a
R10244 T19213 T19212 arg1Of pathway,downstream
R10245 T19213 T19214 arg1Of pathway,of
R10246 T19215 T19214 arg2Of PI3K,of
R10247 T19218 T19216 arg2Of have,seemed
R10248 T19218 T19217 arg1Of have,to
R10249 T19218 T19234 arg1Of have,at
R10250 T19221 T19219 arg1Of response,a
R10251 T19221 T19220 arg1Of response,maximal
R10252 T19221 T19222 arg1Of response,of
R10253 T19221 T19225 arg1Of response,at
R10254 T19221 T19228 arg1Of response,and
R10255 T19224 T19222 arg2Of activation,of
R10256 T19224 T19223 arg1Of activation,Akt
R10257 T19227 T19225 arg2Of hour,at
R10258 T19227 T19226 arg1Of hour,1
R10259 T19228 T19218 arg2Of and,have
R10260 T19231 T19228 arg2Of loss,and
R10261 T19231 T19229 arg1Of loss,a
R10262 T19231 T19230 arg1Of loss,gradual
R10263 T19231 T19232 arg1Of loss,of
R10264 T19233 T19232 arg2Of activity,of
R10265 T19236 T19234 arg2Of hours,at
R10266 T19236 T19235 arg1Of hours,2
R10267 T19238 T19237 arg1Of fact,The
R10268 T19238 T19246 arg1Of fact,suggests
R10269 T19240 T19241 arg1Of Akt,is
R10270 T19240 T19242 arg2Of Akt,phosphorylated
R10271 T19242 T19238 arg2Of phosphorylated,fact
R10272 T19242 T19239 arg1Of phosphorylated,that
R10273 T19242 T19241 arg2Of phosphorylated,is
R10274 T19242 T19243 arg1Of phosphorylated,upon
R10275 T19245 T19243 arg2Of stimulation,upon
R10276 T19245 T19244 arg1Of stimulation,anti-CD3
R10277 T19249 T19246 arg2Of involvement,suggests
R10278 T19249 T19247 arg1Of involvement,the
R10279 T19249 T19248 arg1Of involvement,possible
R10280 T19249 T19250 arg1Of involvement,of
R10281 T19249 T19252 arg1Of involvement,in
R10282 T19251 T19250 arg2Of PI3K,of
R10283 T19254 T19252 arg2Of induction,in
R10284 T19254 T19253 arg1Of induction,the
R10285 T19254 T19255 arg1Of induction,of
R10286 T19254 T19257 arg1Of induction,in
R10287 T19256 T19255 arg2Of IL-17,of
R10288 T19258 T19257 arg2Of RA,in
R10289 T19260 T19259 arg2Of view,In
R10290 T19260 T19261 arg1Of view,of
R10291 T19263 T19261 arg2Of fact,of
R10292 T19263 T19262 arg1Of fact,the
R10293 T19265 T19266 arg1Of NF-κB,was
R10294 T19265 T19268 arg2Of NF-κB,activated
R10295 T19268 T19263 arg2Of activated,fact
R10296 T19268 T19264 arg1Of activated,that
R10297 T19268 T19266 arg2Of activated,was
R10298 T19268 T19267 arg1Of activated,also
R10299 T19272 T19273 arg1Of IL-15,or
R10300 T19273 T19268 arg1Of or,activated
R10301 T19273 T19269 arg2Of or,by
R10302 T19273 T19270 arg1Of or,anti-CD3/anti-CD28
R10303 T19273 T19271 arg1Of or,","
R10304 T19273 T19275 arg1Of or,in
R10305 T19274 T19273 arg2Of mitogens,or
R10306 T19277 T19275 arg2Of experiments,in
R10307 T19277 T19276 arg1Of experiments,our
R10308 T19280 T19259 arg1Of is,In
R10309 T19280 T19278 arg1Of is,","
R10310 T19282 T19280 arg2Of likely,is
R10311 T19282 T19281 arg1Of likely,most
R10312 T19286 T19284 arg1Of pathway,the
R10313 T19286 T19285 arg1Of pathway,NF-κB
R10314 T19286 T19287 arg1Of pathway,is
R10315 T19286 T19290 arg2Of pathway,involved
R10316 T19290 T19279 arg1Of involved,it
R10317 T19290 T19280 arg1Of involved,is
R10318 T19290 T19282 arg1Of involved,likely
R10319 T19290 T19283 arg1Of involved,that
R10320 T19290 T19287 arg2Of involved,is
R10321 T19290 T19288 arg1Of involved,also
R10322 T19290 T19289 arg1Of involved,actively
R10323 T19290 T19291 arg1Of involved,in
R10324 T19293 T19291 arg2Of induction,in
R10325 T19293 T19292 arg1Of induction,the
R10326 T19293 T19294 arg1Of induction,of
R10327 T19293 T19296 arg1Of induction,in
R10328 T19295 T19294 arg2Of IL-17,of
R10329 T19298 T19296 arg2Of PBMC,in
R10330 T19298 T19297 arg1Of PBMC,RA
R10331 T19300 T19299 arg2Of contrast,In
R10332 T19306 T19302 arg1Of pathway,the
R10333 T19306 T19303 arg1Of pathway,AP-1
R10334 T19306 T19304 arg1Of pathway,signal
R10335 T19306 T19305 arg1Of pathway,transduction
R10336 T19306 T19307 arg1Of pathway,","
R10337 T19306 T19315 arg1Of pathway,was
R10338 T19306 T19317 arg2Of pathway,activated
R10339 T19311 T19307 arg2Of pathway,","
R10340 T19311 T19308 arg1Of pathway,another
R10341 T19311 T19309 arg1Of pathway,important
R10342 T19311 T19310 arg1Of pathway,signaling
R10343 T19311 T19312 arg1Of pathway,for
R10344 T19313 T19312 arg2Of cytokines/chemokines,for
R10345 T19317 T19299 arg1Of activated,In
R10346 T19317 T19301 arg1Of activated,","
R10347 T19317 T19314 arg1Of activated,","
R10348 T19317 T19315 arg2Of activated,was
R10349 T19317 T19316 arg1Of activated,not
R10350 T19317 T19318 arg1Of activated,in
R10351 T19320 T19318 arg2Of experiments,in
R10352 T19320 T19319 arg1Of experiments,our
R10353 T19320 T19321 arg1Of experiments,(
R10354 T19322 T19321 arg2Of data,(
R10355 T19322 T19324 arg2Of data,shown
R10356 T19324 T19323 arg1Of shown,not
R10357 T19325 T19321 arg3Of ),(
R10358 T19327 T19328 arg1Of PI3K,and
R10359 T19328 T19337 arg1Of and,have
R10360 T19328 T19338 arg1Of and,been
R10361 T19328 T19339 arg2Of and,reported
R10362 T19328 T19341 arg1Of and,deliver
R10363 T19332 T19328 arg2Of Akt,and
R10364 T19332 T19329 arg1Of Akt,its
R10365 T19332 T19330 arg1Of Akt,downstream
R10366 T19332 T19331 arg1Of Akt,kinase
R10367 T19332 T19333 arg1Of Akt,in
R10368 T19334 T19333 arg2Of association,in
R10369 T19334 T19335 arg1Of association,with
R10370 T19336 T19335 arg2Of NF-κB,with
R10371 T19339 T19326 arg2Of reported,Although
R10372 T19339 T19337 arg2Of reported,have
R10373 T19339 T19338 arg2Of reported,been
R10374 T19341 T19339 arg3Of deliver,reported
R10375 T19341 T19340 arg1Of deliver,to
R10376 T19341 T19344 arg1Of deliver,in
R10377 T19343 T19341 arg2Of signals,deliver
R10378 T19343 T19342 arg1Of signals,activating
R10379 T19347 T19344 arg2Of types,in
R10380 T19347 T19345 arg1Of types,many
R10381 T19347 T19346 arg1Of types,cell
R10382 T19350 T19349 arg1Of data,the
R10383 T19350 T19351 arg1Of data,on
R10384 T19350 T19356 arg1Of data,are
R10385 T19350 T19357 arg1Of data,lacking
R10386 T19353 T19351 arg2Of signal,on
R10387 T19353 T19352 arg1Of signal,the
R10388 T19353 T19354 arg1Of signal,inducing
R10389 T19355 T19354 arg2Of IL-17,inducing
R10390 T19357 T19326 arg1Of lacking,Although
R10391 T19357 T19348 arg1Of lacking,","
R10392 T19357 T19356 arg2Of lacking,are
R10393 T19359 T19358 arg1Of data,Our
R10394 T19359 T19361 arg1Of data,demonstrated
R10395 T19361 T19360 arg1Of demonstrated,clearly
R10396 T19363 T19364 arg1Of PI3K/Akt,and
R10397 T19364 T19368 arg1Of and,could
R10398 T19364 T19369 arg1Of and,be
R10399 T19367 T19364 arg2Of activation,and
R10400 T19367 T19365 arg1Of activation,resultant
R10401 T19367 T19366 arg1Of activation,NF-κB
R10402 T19369 T19361 arg2Of be,demonstrated
R10403 T19369 T19362 arg1Of be,that
R10404 T19369 T19368 arg2Of be,could
R10405 T19372 T19369 arg2Of arbitrator,be
R10406 T19372 T19370 arg1Of arbitrator,an
R10407 T19372 T19371 arg1Of arbitrator,important
R10408 T19372 T19373 arg1Of arbitrator,of
R10409 T19372 T19380 arg1Of arbitrator,","
R10410 T19372 T19381 arg1Of arbitrator,on
R10411 T19375 T19373 arg2Of upregulation,of
R10412 T19375 T19374 arg1Of upregulation,the
R10413 T19375 T19376 arg1Of upregulation,of
R10414 T19375 T19378 arg1Of upregulation,in
R10415 T19377 T19376 arg2Of IL-17,of
R10416 T19379 T19378 arg2Of RA,in
R10417 T19383 T19381 arg2Of basis,on
R10418 T19383 T19382 arg1Of basis,the
R10419 T19383 T19384 arg1Of basis,of
R10420 T19383 T19387 arg1Of basis,showing
R10421 T19386 T19384 arg2Of experiments,of
R10422 T19386 T19385 arg1Of experiments,our
R10423 T19389 T19387 arg2Of blocking,showing
R10424 T19389 T19388 arg1Of blocking,simultaneous
R10425 T19389 T19390 arg1Of blocking,of
R10426 T19389 T19394 arg1Of blocking,in
R10427 T19389 T19398 arg1Of blocking,by
R10428 T19393 T19390 arg2Of activity,of
R10429 T19393 T19391 arg1Of activity,NF-κB
R10430 T19393 T19392 arg1Of activity,binding
R10431 T19397 T19394 arg2Of promoter,in
R10432 T19397 T19395 arg1Of promoter,the
R10433 T19397 T19396 arg1Of promoter,IL-17
R10434 T19399 T19400 arg1Of PDTC,and
R10435 T19400 T19398 arg2Of and,by
R10436 T19401 T19400 arg2Of LY294002,and
R10437 T19402 T19406 arg1Of Considering,and
R10438 T19405 T19402 arg2Of activities,Considering
R10439 T19405 T19403 arg1Of activities,its
R10440 T19405 T19404 arg1Of activities,proinflammatory
R10441 T19406 T19426 arg1Of and,is
R10442 T19408 T19406 arg2Of induction,and
R10443 T19408 T19407 arg1Of induction,successful
R10444 T19408 T19409 arg1Of induction,of
R10445 T19408 T19411 arg1Of induction,for
R10446 T19410 T19409 arg2Of anti-IL-17,of
R10447 T19412 T19411 arg2Of ameliorating,for
R10448 T19412 T19414 arg1Of ameliorating,in
R10449 T19412 T19420 arg1Of ameliorating,","
R10450 T19412 T19421 modOf ameliorating,understanding
R10451 T19413 T19412 arg2Of arthritis,ameliorating
R10452 T19416 T19414 arg2Of models,in
R10453 T19416 T19415 arg1Of models,animal
R10454 T19416 T19417 arg1Of models,[
R10455 T19418 T19417 arg2Of "2,6,34-36",[
R10456 T19419 T19417 arg3Of ],[
R10457 T19425 T19421 arg2Of pathway,understanding
R10458 T19425 T19422 arg1Of pathway,the
R10459 T19425 T19423 arg1Of pathway,IL-17
R10460 T19425 T19424 arg1Of pathway,signaling
R10461 T19429 T19426 arg2Of element,is
R10462 T19429 T19427 arg1Of element,an
R10463 T19429 T19428 arg1Of element,important
R10464 T19429 T19430 arg1Of element,of
R10465 T19431 T19430 arg2Of developing,of
R10466 T19434 T19431 arg2Of therapies,developing
R10467 T19434 T19432 arg1Of therapies,new
R10468 T19434 T19433 arg2Of therapies,targeted
R10469 T19434 T19435 arg1Of therapies,in
R10470 T19436 T19435 arg2Of RA,in
R9423 T18418 T18419 arg1Of IL-17,was
R9424 T18418 T18421 arg2Of IL-17,described
R9425 T18421 T18419 arg2Of described,was
R9426 T18421 T18420 arg1Of described,first
R9427 T18421 T18422 arg1Of described,as
R9428 T18426 T18422 arg2Of product,as
R9429 T18426 T18423 arg1Of product,a
R9430 T18426 T18424 arg1Of product,T
R9431 T18426 T18425 arg1Of product,cell
R9432 T18426 T18427 arg1Of product,with
R9433 T18429 T18427 arg2Of properties,with
R9434 T18429 T18428 arg1Of properties,proinflammatory
R9435 T18429 T18430 arg1Of properties,[
R9436 T18431 T18430 arg2Of "5,22",[
R9437 T18432 T18430 arg3Of ],[
R9438 T18433 T18434 arg1Of RA,is
R9439 T18433 T18435 arg2Of RA,characterized
R9440 T18435 T18434 arg2Of characterized,is
R9441 T18435 T18449 arg1Of characterized,[
R9442 T18437 T18438 arg1Of hyperplasia,of
R9443 T18437 T18442 arg1Of hyperplasia,and
R9444 T18441 T18438 arg2Of cells,of
R9445 T18441 T18439 arg1Of cells,synovial
R9446 T18441 T18440 arg1Of cells,lining
R9447 T18442 T18435 arg1Of and,characterized
R9448 T18442 T18436 arg2Of and,by
R9449 T18445 T18442 arg2Of infiltration,and
R9450 T18445 T18443 arg1Of infiltration,an
R9451 T18445 T18444 arg1Of infiltration,intense
R9452 T18445 T18446 arg1Of infiltration,by
R9453 T18448 T18446 arg2Of cells,by
R9454 T18448 T18447 arg1Of cells,mononuclear
R9455 T18450 T18449 arg2Of 23,[
R9456 T18451 T18449 arg3Of ],[
R9457 T18453 T18452 arg1Of cytokines,Proinflammatory
R9458 T18453 T18455 arg1Of cytokines,as
R9459 T18453 T18459 arg1Of cytokines,are
R9460 T18453 T18460 arg1Of cytokines,abundant
R9461 T18455 T18454 arg1Of as,such
R9462 T18456 T18457 arg1Of IL-1,and
R9463 T18457 T18455 arg2Of and,as
R9464 T18458 T18457 arg2Of TNF-α,and
R9465 T18459 T18465 arg1Of are,whereas
R9466 T18460 T18459 arg2Of abundant,are
R9467 T18460 T18461 arg1Of abundant,in
R9468 T18463 T18461 arg2Of synovium,in
R9469 T18463 T18462 arg1Of synovium,rheumatoid
R9470 T18465 T18464 arg1Of whereas,","
R9471 T18468 T18467 arg1Of cell-derived,T
R9472 T18469 T18466 arg1Of cytokines,the
R9473 T18469 T18468 arg1Of cytokines,cell-derived
R9474 T18469 T18470 arg1Of cytokines,","
R9475 T18469 T18476 arg1Of cytokines,have
R9476 T18469 T18478 arg1Of cytokines,proved
R9477 T18469 T18479 arg1Of cytokines,difficult
R9478 T18469 T18481 arg2Of cytokines,detect
R9479 T18472 T18473 arg1Of IL-4,and
R9480 T18473 T18470 arg2Of and,","
R9481 T18473 T18471 arg1Of and,especially
R9482 T18474 T18473 arg2Of interferon-γ,and
R9483 T18478 T18465 arg2Of proved,whereas
R9484 T18478 T18475 arg1Of proved,","
R9485 T18478 T18476 arg2Of proved,have
R9486 T18478 T18477 arg1Of proved,often
R9487 T18479 T18478 arg2Of difficult,proved
R9488 T18481 T18479 arg2Of detect,difficult
R9489 T18481 T18480 arg1Of detect,to
R9490 T18481 T18482 arg1Of detect,in
R9491 T18481 T18485 arg1Of detect,[
R9492 T18484 T18482 arg2Of synovium,in
R9493 T18484 T18483 arg1Of synovium,RA
R9494 T18486 T18485 arg2Of 24,[
R9495 T18487 T18485 arg3Of ],[
R9496 T18490 T18489 arg1Of cells,T
R9497 T18490 T18491 arg1Of cells,may
R9498 T18490 T18492 arg1Of cells,have
R9499 T18492 T18488 arg2Of have,Although
R9500 T18492 T18491 arg2Of have,may
R9501 T18492 T18495 arg1Of have,in
R9502 T18494 T18492 arg2Of role,have
R9503 T18494 T18493 arg1Of role,a
R9504 T18497 T18495 arg2Of augmentation,in
R9505 T18497 T18496 arg1Of augmentation,the
R9506 T18497 T18498 arg1Of augmentation,of
R9507 T18501 T18498 arg2Of inflammation,of
R9508 T18501 T18499 arg1Of inflammation,rheumatoid
R9509 T18501 T18500 arg1Of inflammation,synovial
R9510 T18504 T18503 arg1Of lack,the
R9511 T18504 T18505 arg1Of lack,of
R9512 T18504 T18509 arg1Of lack,has
R9513 T18504 T18510 arg1Of lack,limited
R9514 T18508 T18505 arg2Of cytokines,of
R9515 T18508 T18506 arg1Of cytokines,T
R9516 T18508 T18507 arg1Of cytokines,cell-derived
R9517 T18510 T18488 arg1Of limited,Although
R9518 T18510 T18502 arg1Of limited,","
R9519 T18510 T18509 arg2Of limited,has
R9520 T18512 T18510 arg2Of importance,limited
R9521 T18512 T18511 arg1Of importance,its
R9522 T18515 T18513 arg2Of respect,In
R9523 T18515 T18514 arg1Of respect,this
R9524 T18517 T18518 arg1Of IL-17,is
R9525 T18517 T18519 arg1Of IL-17,appealing
R9526 T18519 T18513 arg1Of appealing,In
R9527 T18519 T18516 arg1Of appealing,","
R9528 T18519 T18518 arg2Of appealing,is
R9529 T18519 T18520 arg1Of appealing,because
R9530 T18521 T18522 arg1Of it,has
R9531 T18521 T18523 arg1Of it,been
R9532 T18521 T18524 arg2Of it,described
R9533 T18524 T18520 arg2Of described,because
R9534 T18524 T18522 arg2Of described,has
R9535 T18524 T18523 arg2Of described,been
R9536 T18524 T18525 arg1Of described,as
R9537 T18529 T18525 arg2Of cytokine,as
R9538 T18529 T18526 arg1Of cytokine,a
R9539 T18529 T18527 arg1Of cytokine,T
R9540 T18529 T18528 arg1Of cytokine,cell-derived
R9541 T18529 T18530 arg1Of cytokine,with
R9542 T18532 T18530 arg2Of properties,with
R9543 T18532 T18531 arg1Of properties,proinflammatory
R9544 T18535 T18533 arg2Of studies,In
R9545 T18535 T18534 arg1Of studies,our
R9546 T18537 T18538 arg1Of we,tried
R9547 T18537 T18540 arg1Of we,evaluate
R9548 T18538 T18533 arg1Of tried,In
R9549 T18538 T18536 arg1Of tried,","
R9550 T18538 T18550 arg1Of tried,and
R9551 T18540 T18538 arg2Of evaluate,tried
R9552 T18540 T18539 arg1Of evaluate,to
R9553 T18541 T18540 arg2Of how,evaluate
R9554 T18543 T18542 arg1Of production,IL-17
R9555 T18543 T18544 arg1Of production,is
R9556 T18543 T18545 arg2Of production,regulated
R9557 T18545 T18541 arg1Of regulated,how
R9558 T18545 T18544 arg2Of regulated,is
R9559 T18545 T18546 arg1Of regulated,in
R9560 T18548 T18546 arg2Of PBMC,in
R9561 T18548 T18547 arg1Of PBMC,RA
R9562 T18550 T18549 arg1Of and,","
R9563 T18553 T18551 arg1Of pathway,which
R9564 T18553 T18552 arg1Of pathway,signaling
R9565 T18553 T18555 arg2Of pathway,used
R9566 T18554 T18555 arg1Of it,used
R9567 T18555 T18550 arg2Of used,and
R9568 T18556 T18557 arg1Of Levels,of
R9569 T18556 T18559 arg1Of Levels,were
R9570 T18556 T18560 arg2Of Levels,found
R9571 T18556 T18562 arg1Of Levels,be
R9572 T18556 T18563 arg1Of Levels,higher
R9573 T18558 T18557 arg2Of IL-17,of
R9574 T18560 T18559 arg2Of found,were
R9575 T18562 T18560 arg3Of be,found
R9576 T18562 T18561 arg1Of be,to
R9577 T18563 T18562 arg2Of higher,be
R9578 T18563 T18564 arg1Of higher,in
R9579 T18563 T18568 arg1Of higher,than
R9580 T18567 T18564 arg2Of fluid,in
R9581 T18567 T18565 arg1Of fluid,RA
R9582 T18567 T18566 arg1Of fluid,synovial
R9583 T18569 T18568 arg2Of in,than
R9584 T18572 T18569 arg2Of fluid,in
R9585 T18572 T18570 arg1Of fluid,OA
R9586 T18572 T18571 arg1Of fluid,synovial
R9587 T18572 T18573 arg1Of fluid,[
R9588 T18574 T18573 arg2Of 15,[
R9589 T18575 T18573 arg3Of ],[
R9590 T18578 T18579 arg1Of there,are
R9591 T18579 T18576 arg1Of are,However
R9592 T18579 T18577 arg1Of are,","
R9593 T18581 T18579 arg2Of data,are
R9594 T18581 T18580 arg1Of data,few
R9595 T18581 T18582 arg1Of data,available
R9596 T18581 T18586 arg1Of data,that
R9597 T18581 T18587 arg1Of data,stimulate
R9598 T18582 T18583 arg1Of available,on
R9599 T18585 T18583 arg2Of agents,on
R9600 T18585 T18584 arg1Of agents,the
R9601 T18587 T18592 arg1Of stimulate,","
R9602 T18587 T18593 arg1Of stimulate,although
R9603 T18589 T18587 arg2Of production,stimulate
R9604 T18589 T18588 arg1Of production,IL-17
R9605 T18589 T18590 arg1Of production,in
R9606 T18591 T18590 arg2Of RA,in
R9607 T18596 T18594 arg1Of level,the
R9608 T18596 T18595 arg1Of level,highest
R9609 T18596 T18597 arg1Of level,of
R9610 T18596 T18600 arg1Of level,can
R9611 T18596 T18601 arg1Of level,be
R9612 T18596 T18602 arg2Of level,achieved
R9613 T18599 T18597 arg2Of production,of
R9614 T18599 T18598 arg1Of production,IL-17
R9615 T18602 T18593 arg2Of achieved,although
R9616 T18602 T18600 arg2Of achieved,can
R9617 T18602 T18601 arg2Of achieved,be
R9618 T18602 T18609 arg1Of achieved,[
R9619 T18605 T18602 arg1Of stimulation,achieved
R9620 T18605 T18603 arg2Of stimulation,by
R9621 T18605 T18604 arg1Of stimulation,anti-CD3/anti-CD28
R9622 T18605 T18606 arg1Of stimulation,in
R9623 T18608 T18606 arg2Of individuals,in
R9624 T18608 T18607 arg1Of individuals,healthy
R9625 T18610 T18609 arg2Of 25,[
R9626 T18611 T18609 arg3Of ],[
R9627 T18614 T18612 arg2Of experiments,In
R9628 T18614 T18613 arg1Of experiments,our
R9629 T18616 T18617 arg1Of PHA,as
R9630 T18616 T18632 arg1Of PHA,increased
R9631 T18618 T18622 arg1Of mitogens,as
R9632 T18622 T18617 arg2Of as,as
R9633 T18622 T18619 arg1Of as,","
R9634 T18622 T18620 arg1Of as,as
R9635 T18622 T18621 arg1Of as,well
R9636 T18622 T18624 arg1Of as,for
R9637 T18623 T18622 arg2Of anti-CD3/anti-CD28,as
R9638 T18625 T18624 arg2Of signaling,for
R9639 T18625 T18626 arg1Of signaling,through
R9640 T18630 T18626 arg2Of receptor,through
R9641 T18630 T18627 arg1Of receptor,the
R9642 T18630 T18628 arg1Of receptor,T
R9643 T18630 T18629 arg1Of receptor,cell
R9644 T18632 T18612 arg1Of increased,In
R9645 T18632 T18615 arg1Of increased,","
R9646 T18632 T18631 arg1Of increased,","
R9647 T18632 T18638 arg1Of increased,in
R9648 T18634 T18632 arg2Of production,increased
R9649 T18634 T18633 arg1Of production,IL-17
R9650 T18634 T18635 arg1Of production,from
R9651 T18637 T18635 arg2Of PBMC,from
R9652 T18637 T18636 arg1Of PBMC,RA
R9653 T18641 T18638 arg2Of manner,in
R9654 T18641 T18639 arg1Of manner,a
R9655 T18641 T18640 arg1Of manner,dose-dependent
R9656 T18642 T18643 arg1Of We,found
R9657 T18643 T18644 arg1Of found,","
R9658 T18643 T18645 arg1Of found,by
R9659 T18643 T18655 arg1Of found,","
R9660 T18649 T18645 arg2Of assay,by
R9661 T18649 T18646 arg1Of assay,a
R9662 T18649 T18647 arg1Of assay,cell
R9663 T18649 T18648 arg1Of assay,proliferation
R9664 T18649 T18650 arg1Of assay,(
R9665 T18651 T18650 arg2Of data,(
R9666 T18651 T18653 arg2Of data,shown
R9667 T18653 T18652 arg1Of shown,not
R9668 T18654 T18650 arg3Of ),(
R9669 T18658 T18657 arg1Of upregulation,this
R9670 T18658 T18659 arg1Of upregulation,of
R9671 T18658 T18661 arg1Of upregulation,might
R9672 T18658 T18662 arg1Of upregulation,be
R9673 T18658 T18664 arg1Of upregulation,to
R9674 T18658 T18670 arg1Of upregulation,to
R9675 T18660 T18659 arg2Of IL-17,of
R9676 T18662 T18643 arg2Of be,found
R9677 T18662 T18656 arg1Of be,that
R9678 T18662 T18661 arg2Of be,might
R9679 T18664 T18663 arg1Of to,due
R9680 T18664 T18669 arg1Of to,than
R9681 T18667 T18664 arg2Of activity,to
R9682 T18667 T18665 arg2Of activity,increased
R9683 T18667 T18666 arg1Of activity,cellular
R9684 T18669 T18662 arg2Of than,be
R9685 T18669 T18668 arg1Of than,rather
R9686 T18670 T18669 arg2Of to,than
R9687 T18672 T18670 arg2Of proliferation,to
R9688 T18672 T18671 arg1Of proliferation,cellular
R9689 T18673 T18674 arg1Of IL-17,is
R9690 T18673 T18675 arg2Of IL-17,produced
R9691 T18675 T18674 arg2Of produced,is
R9692 T18675 T18676 arg1Of produced,mainly
R9693 T18675 T18692 arg1Of produced,[
R9694 T18681 T18678 arg2Of cells,activated
R9695 T18681 T18679 arg1Of cells,CD4+
R9696 T18681 T18680 arg1Of cells,T
R9697 T18681 T18682 arg1Of cells,","
R9698 T18681 T18684 arg1Of cells,for
R9699 T18681 T18687 arg1Of cells,","
R9700 T18684 T18683 arg1Of for,especially
R9701 T18686 T18684 arg2Of cells,for
R9702 T18686 T18685 arg1Of cells,Th1/Th0
R9703 T18687 T18675 arg1Of ",",produced
R9704 T18687 T18677 arg2Of ",",by
R9705 T18691 T18687 arg2Of phenotype,","
R9706 T18691 T18688 arg1Of phenotype,not
R9707 T18691 T18689 arg1Of phenotype,the
R9708 T18691 T18690 arg1Of phenotype,Th2
R9709 T18693 T18692 arg2Of 26,[
R9710 T18694 T18692 arg3Of ],[
R9711 T18697 T18698 arg1Of it,can
R9712 T18697 T18700 arg1Of it,be
R9713 T18697 T18701 arg2Of it,produced
R9714 T18701 T18695 arg1Of produced,However
R9715 T18701 T18696 arg1Of produced,","
R9716 T18701 T18698 arg2Of produced,can
R9717 T18701 T18699 arg1Of produced,also
R9718 T18701 T18700 arg2Of produced,be
R9719 T18701 T18706 arg1Of produced,via
R9720 T18705 T18701 arg1Of cells,produced
R9721 T18705 T18702 arg2Of cells,by
R9722 T18705 T18703 arg1Of cells,CD8+
R9723 T18705 T18704 arg1Of cells,T
R9724 T18710 T18706 arg2Of mechanism,via
R9725 T18710 T18707 arg1Of mechanism,an
R9726 T18710 T18708 arg1Of mechanism,IL-23
R9727 T18710 T18709 arg1Of mechanism,triggering
R9728 T18710 T18711 arg1Of mechanism,in
R9729 T18714 T18711 arg2Of infection,in
R9730 T18714 T18712 arg1Of infection,Gram-negative
R9731 T18714 T18713 arg1Of infection,pulmonary
R9732 T18714 T18715 arg1Of infection,[
R9733 T18716 T18715 arg2Of 14,[
R9734 T18717 T18715 arg3Of ],[
R9735 T18719 T18718 arg2Of addition,In
R9736 T18722 T18721 arg1Of production,IL-17
R9737 T18722 T18723 arg1Of production,was
R9738 T18722 T18725 arg2Of production,augmented
R9739 T18725 T18718 arg1Of augmented,In
R9740 T18725 T18720 arg1Of augmented,","
R9741 T18725 T18723 arg2Of augmented,was
R9742 T18725 T18724 arg1Of augmented,significantly
R9743 T18728 T18725 arg1Of cells,augmented
R9744 T18728 T18726 arg2Of cells,by
R9745 T18728 T18727 arg1Of cells,T
R9746 T18728 T18729 arg1Of cells,recognizing
R9747 T18729 T18733 arg1Of recognizing,in
R9748 T18729 T18738 arg1Of recognizing,[
R9749 T18732 T18729 arg2Of collagen,recognizing
R9750 T18732 T18730 arg1Of collagen,type
R9751 T18732 T18731 arg1Of collagen,II
R9752 T18737 T18733 arg2Of model,in
R9753 T18737 T18734 arg1Of model,a
R9754 T18737 T18735 arg1Of model,collagen-induced
R9755 T18737 T18736 arg1Of model,arthritis
R9756 T18739 T18738 arg2Of 27,[
R9757 T18740 T18738 arg3Of ],[
R9758 T18743 T18741 arg1Of interaction,A
R9759 T18743 T18742 arg1Of interaction,complex
R9760 T18743 T18744 arg1Of interaction,between
R9761 T18743 T18750 arg1Of interaction,might
R9762 T18743 T18751 arg1Of interaction,produce
R9763 T18745 T18744 arg2Of cells,between
R9764 T18745 T18746 arg1Of cells,in
R9765 T18749 T18746 arg2Of joints,in
R9766 T18749 T18747 arg1Of joints,inflamed
R9767 T18749 T18748 arg1Of joints,RA
R9768 T18751 T18750 arg2Of produce,might
R9769 T18753 T18751 arg2Of variety,produce
R9770 T18753 T18752 arg1Of variety,a
R9771 T18753 T18754 arg1Of variety,of
R9772 T18756 T18757 arg1Of cytokines,and
R9773 T18757 T18754 arg2Of and,of
R9774 T18757 T18755 arg1Of and,proinflammatory
R9775 T18757 T18759 arg1Of and,","
R9776 T18757 T18760 arg1Of and,which
R9777 T18757 T18762 arg1Of and,activate
R9778 T18758 T18757 arg2Of chemokines,and
R9779 T18762 T18761 arg1Of activate,also
R9780 T18762 T18765 arg1Of activate,in
R9781 T18764 T18762 arg2Of cells,activate
R9782 T18764 T18763 arg1Of cells,other
R9783 T18767 T18765 arg2Of joints,in
R9784 T18767 T18766 arg1Of joints,the
R9785 T18769 T18768 arg2Of example,For
R9786 T18771 T18772 arg1Of IL-17,stimulates
R9787 T18772 T18768 arg1Of stimulates,For
R9788 T18772 T18770 arg1Of stimulates,","
R9789 T18774 T18772 arg2Of synoviocytes,stimulates
R9790 T18774 T18773 arg1Of synoviocytes,rheumatoid
R9791 T18774 T18776 arg1Of synoviocytes,secrete
R9792 T18776 T18772 arg3Of secrete,stimulates
R9793 T18776 T18775 arg1Of secrete,to
R9794 T18778 T18776 arg2Of cytokines,secrete
R9795 T18778 T18777 arg1Of cytokines,several
R9796 T18778 T18780 arg1Of cytokines,as
R9797 T18780 T18779 arg1Of as,such
R9798 T18781 T18782 arg1Of IL-6,","
R9799 T18782 T18784 arg1Of ",",and
R9800 T18783 T18782 arg2Of IL-8,","
R9801 T18784 T18792 arg1Of and,as
R9802 T18788 T18784 arg2Of gene,and
R9803 T18788 T18785 arg1Of gene,tumor
R9804 T18788 T18786 arg1Of gene,necrosis
R9805 T18788 T18787 arg1Of gene,factor-stimulated
R9806 T18788 T18789 arg1Of gene,6
R9807 T18792 T18780 arg2Of as,as
R9808 T18792 T18790 arg1Of as,as
R9809 T18792 T18791 arg1Of as,well
R9810 T18794 T18792 arg2Of E2,as
R9811 T18794 T18793 arg1Of E2,prostaglandin
R9812 T18794 T18796 arg1Of E2,vitro
R9813 T18794 T18797 arg1Of E2,[
R9814 T18796 T18795 arg1Of vitro,in
R9815 T18798 T18797 arg2Of "12,28,29",[
R9816 T18799 T18797 arg3Of ],[
R9817 T18800 T18801 arg1Of There,are
R9818 T18804 T18802 arg1Of few,as
R9819 T18804 T18803 arg1Of few,yet
R9820 T18805 T18801 arg2Of data,are
R9821 T18805 T18804 arg1Of data,few
R9822 T18805 T18806 arg1Of data,available
R9823 T18806 T18807 arg1Of available,on
R9824 T18809 T18807 arg2Of agents,on
R9825 T18809 T18808 arg1Of agents,the
R9826 T18809 T18810 arg1Of agents,that
R9827 T18809 T18811 arg1Of agents,stimulate
R9828 T18811 T18816 arg1Of stimulate,","
R9829 T18811 T18817 arg1Of stimulate,although
R9830 T18813 T18811 arg2Of production,stimulate
R9831 T18813 T18812 arg1Of production,IL-17
R9832 T18813 T18814 arg1Of production,in
R9833 T18815 T18814 arg2Of RA,in
R9834 T18819 T18818 arg1Of cytokines,some
R9835 T18819 T18820 arg1Of cytokines,(
R9836 T18819 T18825 arg1Of cytokines,have
R9837 T18819 T18826 arg1Of cytokines,been
R9838 T18819 T18827 arg2Of cytokines,known
R9839 T18819 T18829 arg1Of cytokines,regulate
R9840 T18821 T18822 arg1Of IL-15,and
R9841 T18822 T18820 arg2Of and,(
R9842 T18823 T18822 arg2Of IL-23,and
R9843 T18824 T18820 arg3Of ),(
R9844 T18827 T18817 arg2Of known,although
R9845 T18827 T18825 arg2Of known,have
R9846 T18827 T18826 arg2Of known,been
R9847 T18829 T18827 arg3Of regulate,known
R9848 T18829 T18828 arg1Of regulate,to
R9849 T18829 T18832 arg1Of regulate,[
R9850 T18831 T18829 arg2Of production,regulate
R9851 T18831 T18830 arg1Of production,IL-17
R9852 T18833 T18832 arg2Of "13,14",[
R9853 T18834 T18832 arg3Of ],[
R9854 T18835 T18837 arg1Of We,investigated
R9855 T18837 T18836 arg1Of investigated,therefore
R9856 T18837 T18865 modOf investigated,using
R9857 T18840 T18839 arg1Of vitro,in
R9858 T18841 T18840 arg1Of production,vitro
R9859 T18841 T18842 arg1Of production,of
R9860 T18841 T18844 arg1Of production,in
R9861 T18841 T18857 arg1Of production,as
R9862 T18843 T18842 arg2Of IL-17,of
R9863 T18846 T18844 arg2Of PBMC,in
R9864 T18846 T18845 arg1Of PBMC,RA
R9865 T18846 T18847 arg1Of PBMC,responding
R9866 T18847 T18848 arg1Of responding,to
R9867 T18850 T18848 arg2Of variety,to
R9868 T18850 T18849 arg1Of variety,a
R9869 T18850 T18851 arg1Of variety,of
R9870 T18852 T18853 arg1Of cytokines/chemokines,and
R9871 T18853 T18851 arg2Of and,of
R9872 T18854 T18853 arg2Of mitogens,and
R9873 T18857 T18837 arg2Of as,investigated
R9874 T18857 T18838 arg1Of as,the
R9875 T18857 T18855 arg1Of as,as
R9876 T18857 T18856 arg1Of as,well
R9877 T18860 T18858 arg1Of receptor,T
R9878 T18860 T18859 arg1Of receptor,cell
R9879 T18860 T18861 arg1Of receptor,(
R9880 T18862 T18861 arg2Of TCR,(
R9881 T18863 T18861 arg3Of ),(
R9882 T18864 T18857 arg2Of ligation,as
R9883 T18864 T18860 arg1Of ligation,receptor
R9884 T18866 T18865 arg2Of anti-CD3/anti-CD28,using
R9885 T18868 T18867 arg1Of studies,Our
R9886 T18868 T18869 arg1Of studies,demonstrated
R9887 T18871 T18872 arg1Of IL-15,and
R9888 T18872 T18876 arg1Of and,as
R9889 T18873 T18872 arg2Of MCP-1,and
R9890 T18876 T18874 arg1Of as,as
R9891 T18876 T18875 arg1Of as,well
R9892 T18876 T18880 arg1Of as,increased
R9893 T18878 T18876 arg2Of ligation,as
R9894 T18878 T18877 arg1Of ligation,TCR
R9895 T18880 T18869 arg2Of increased,demonstrated
R9896 T18880 T18870 arg1Of increased,that
R9897 T18880 T18879 arg1Of increased,significantly
R9898 T18882 T18880 arg2Of production,increased
R9899 T18882 T18881 arg1Of production,the
R9900 T18882 T18883 arg1Of production,of
R9901 T18882 T18885 arg1Of production,in
R9902 T18884 T18883 arg2Of IL-17,of
R9903 T18887 T18885 arg2Of PBMC,in
R9904 T18887 T18886 arg1Of PBMC,RA
R9905 T18889 T18890 arg1Of IL-15,or
R9906 T18890 T18888 arg1Of or,Adding
R9907 T18890 T18892 arg1Of or,to
R9908 T18890 T18895 arg1Of or,augmented
R9909 T18891 T18890 arg2Of MCP-1,or
R9910 T18894 T18892 arg2Of ligation,to
R9911 T18894 T18893 arg1Of ligation,TCR
R9912 T18895 T18899 arg1Of augmented,markedly
R9913 T18897 T18895 arg2Of production,augmented
R9914 T18897 T18896 arg1Of production,IL-17
R9915 T18899 T18898 arg1Of markedly,more
R9916 T18901 T18900 arg2Of contrast,In
R9917 T18903 T18904 arg1Of IL-1,and
R9918 T18904 T18906 arg1Of and,","
R9919 T18904 T18907 arg1Of and,which
R9920 T18904 T18908 arg1Of and,are
R9921 T18904 T18909 arg2Of and,known
R9922 T18904 T18911 arg1Of and,have
R9923 T18904 T18916 arg1Of and,be
R9924 T18904 T18917 arg2Of and,increased
R9925 T18904 T18922 arg1Of and,did
R9926 T18904 T18924 arg1Of and,affect
R9927 T18905 T18904 arg2Of TNF-α,and
R9928 T18909 T18908 arg2Of known,are
R9929 T18911 T18910 arg1Of have,to
R9930 T18911 T18914 arg1Of have,and
R9931 T18913 T18911 arg2Of properties,have
R9932 T18913 T18912 arg1Of properties,proinflammatory
R9933 T18914 T18909 arg3Of and,known
R9934 T18917 T18914 arg2Of increased,and
R9935 T18917 T18915 arg1Of increased,to
R9936 T18917 T18916 arg2Of increased,be
R9937 T18917 T18918 arg1Of increased,in
R9938 T18920 T18918 arg2Of joints,in
R9939 T18920 T18919 arg1Of joints,RA
R9940 T18924 T18900 arg1Of affect,In
R9941 T18924 T18902 arg1Of affect,","
R9942 T18924 T18921 arg1Of affect,","
R9943 T18924 T18922 arg2Of affect,did
R9944 T18924 T18923 arg1Of affect,not
R9945 T18926 T18924 arg2Of production,affect
R9946 T18926 T18925 arg1Of production,IL-17
R9947 T18928 T18927 arg1Of data,Our
R9948 T18928 T18929 arg1Of data,were
R9949 T18928 T18930 arg1Of data,consistent
R9950 T18930 T18929 arg2Of consistent,were
R9951 T18930 T18931 arg1Of consistent,with
R9952 T18934 T18931 arg2Of report,with
R9953 T18934 T18932 arg1Of report,a
R9954 T18934 T18933 arg1Of report,recent
R9955 T18936 T18937 arg1Of IL-15,triggered
R9956 T18937 T18945 arg1Of triggered,but
R9957 T18939 T18938 arg1Of vitro,in
R9958 T18941 T18937 arg2Of production,triggered
R9959 T18941 T18939 arg1Of production,vitro
R9960 T18941 T18940 arg1Of production,IL-17
R9961 T18941 T18942 arg1Of production,in
R9962 T18943 T18942 arg2Of PBMC,in
R9963 T18945 T18934 arg2Of but,report
R9964 T18945 T18935 arg1Of but,that
R9965 T18945 T18944 arg1Of but,","
R9966 T18946 T18947 arg1Of TNF-α,did
R9967 T18946 T18949 arg1Of TNF-α,do
R9968 T18946 T18950 arg1Of TNF-α,so
R9969 T18949 T18945 arg2Of do,but
R9970 T18949 T18947 arg2Of do,did
R9971 T18949 T18948 arg1Of do,not
R9972 T18949 T18951 arg1Of do,[
R9973 T18950 T18949 arg2Of so,do
R9974 T18952 T18951 arg2Of 13,[
R9975 T18953 T18951 arg3Of ],[
R9976 T18955 T18956 arg1Of there,were
R9977 T18956 T18954 arg2Of were,Although
R9978 T18958 T18956 arg2Of data,were
R9979 T18958 T18957 arg1Of data,no
R9980 T18958 T18959 arg1Of data,that
R9981 T18960 T18962 arg1Of MCP-1,induces
R9982 T18962 T18959 arg2Of induces,that
R9983 T18962 T18961 arg1Of induces,directly
R9984 T18965 T18962 arg2Of activation,induces
R9985 T18965 T18963 arg1Of activation,T
R9986 T18965 T18964 arg1Of activation,cell
R9987 T18967 T18968 arg1Of it,might
R9988 T18967 T18969 arg1Of it,exert
R9989 T18969 T18954 arg1Of exert,Although
R9990 T18969 T18966 arg1Of exert,","
R9991 T18969 T18968 arg2Of exert,might
R9992 T18969 T18971 arg1Of exert,indirectly
R9993 T18969 T18972 arg1Of exert,on
R9994 T18969 T18975 arg1Of exert,through
R9995 T18970 T18969 arg2Of effects,exert
R9996 T18974 T18972 arg2Of cells,on
R9997 T18974 T18973 arg1Of cells,T
R9998 T18977 T18975 arg2Of activation,through
R9999 T18977 T18976 arg1Of activation,the