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PMC:1064895 JSONTXT 32 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T664 0-9 VB denotes Increased
T665 10-24 NN denotes interleukin-17
T666 25-35 NN denotes production
T667 36-39 IN denotes via
T668 40-41 DT denotes a
T669 42-58 NN denotes phosphoinositide
T670 59-71 NN denotes 3-kinase/Akt
T671 72-75 CC denotes and
T672 76-83 JJ denotes nuclear
T673 84-90 NN denotes factor
T674 91-102 JJ denotes κB-dependen
T675 102-109 NN denotes t pathw
T676 109-111 IN denotes ay
T677 112-120 NN denotes in patie
T678 120-124 IN denotes nts
T679 124-134 JJ denotes with rheum
T680 134-143 NN denotes atoid art
T681 160-172 JJ denotes Inflammatory
T682 173-182 NN denotes mediators
T683 183-187 VB denotes have
T684 188-192 VB denotes been
T685 193-203 VB denotes recognized
T686 204-206 IN denotes as
T687 207-212 VB denotes being
T688 213-222 JJ denotes important
T689 223-225 IN denotes in
T690 226-229 DT denotes the
T691 230-242 NN denotes pathogenesis
T692 243-245 IN denotes of
T693 246-256 JJ denotes rheumatoid
T694 257-266 NN denotes arthritis
T695 267-268 -LRB- denotes (
T696 268-270 NN denotes RA
T697 270-271 -RRB- denotes )
T698 273-284 NN denotes Interleukin
T699 285-286 -LRB- denotes (
T700 286-288 NN denotes IL
T701 288-289 -RRB- denotes )
T702 289-292 CD denotes -17
T703 293-295 VB denotes is
T704 296-298 DT denotes an
T705 299-308 JJ denotes important
T706 309-318 NN denotes regulator
T707 319-321 IN denotes of
T708 322-328 JJ denotes immune
T709 329-332 CC denotes and
T710 333-345 JJ denotes inflammatory
T711 346-355 NN denotes responses
T712 355-356 -COMMA- denotes ,
T713 357-366 VB denotes including
T714 367-370 DT denotes the
T715 371-380 NN denotes induction
T716 381-383 IN denotes of
T717 384-399 JJ denotes proinflammatory
T718 400-409 NN denotes cytokines
T719 410-413 CC denotes and
T720 414-426 JJ denotes osteoclastic
T721 427-431 NN denotes bone
T722 432-442 NN denotes resorption
T723 444-452 NN denotes Evidence
T724 453-456 IN denotes for
T725 457-460 DT denotes the
T726 461-471 NN denotes expression
T727 472-475 CC denotes and
T728 476-491 JJ denotes proinflammatory
T729 492-500 NN denotes activity
T730 501-503 IN denotes of
T731 504-509 NN denotes IL-17
T732 510-513 VB denotes has
T733 514-518 VB denotes been
T734 519-531 VB denotes demonstrated
T735 532-534 IN denotes in
T736 535-537 NN denotes RA
T737 538-546 NN denotes synovium
T738 547-550 CC denotes and
T739 551-553 IN denotes in
T740 554-560 NN denotes animal
T741 561-567 NN denotes models
T742 568-570 IN denotes of
T743 571-573 NN denotes RA
T744 575-583 IN denotes Although
T745 584-588 DT denotes some
T746 589-598 NN denotes cytokines
T747 599-600 -LRB- denotes (
T748 600-605 NN denotes IL-15
T749 606-609 CC denotes and
T750 610-615 NN denotes IL-23
T751 615-616 -RRB- denotes )
T752 617-621 VB denotes have
T753 622-626 VB denotes been
T754 627-635 VB denotes reported
T755 636-638 TO denotes to
T756 639-647 VB denotes regulate
T757 648-653 NN denotes IL-17
T758 654-664 NN denotes production
T759 664-665 -COMMA- denotes ,
T760 666-669 DT denotes the
T761 670-683 JJ denotes intracellular
T762 684-693 NN denotes signaling
T763 694-702 NN denotes pathways
T764 703-707 WDT denotes that
T765 708-716 VB denotes regulate
T766 717-722 NN denotes IL-17
T767 723-733 NN denotes production
T768 734-740 VB denotes remain
T769 741-748 JJ denotes unknown
T770 750-752 IN denotes In
T771 753-756 DT denotes the
T772 757-764 JJ denotes present
T773 765-770 NN denotes study
T774 770-771 -COMMA- denotes ,
T775 772-774 PRP denotes we
T776 775-787 VB denotes investigated
T777 788-791 DT denotes the
T778 792-796 NN denotes role
T779 797-799 IN denotes of
T780 800-803 DT denotes the
T781 804-820 NN denotes phosphoinositide
T782 821-829 NN denotes 3-kinase
T783 830-831 -LRB- denotes (
T784 831-835 NN denotes PI3K
T785 835-836 -RRB- denotes )
T786 836-840 NN denotes /Akt
T787 841-848 NN denotes pathway
T788 849-851 IN denotes in
T789 852-855 DT denotes the
T790 856-866 NN denotes regulation
T791 867-869 IN denotes of
T792 870-875 NN denotes IL-17
T793 876-886 NN denotes production
T794 887-889 IN denotes in
T795 890-892 NN denotes RA
T796 894-904 JJ denotes Peripheral
T797 905-910 NN denotes blood
T798 911-922 JJ denotes mononuclear
T799 923-928 NN denotes cells
T800 929-930 -LRB- denotes (
T801 930-934 NN denotes PBMC
T802 934-935 -RRB- denotes )
T803 936-940 IN denotes from
T804 941-949 NN denotes patients
T805 950-954 IN denotes with
T806 955-957 NN denotes RA
T807 958-959 -LRB- denotes (
T808 959-960 NN denotes n
T809 961-962 SYM denotes =
T810 963-965 CD denotes 24
T811 965-966 -RRB- denotes )
T812 967-971 VB denotes were
T813 972-981 VB denotes separated
T814 981-982 -COMMA- denotes ,
T815 983-987 RB denotes then
T816 988-998 VB denotes stimulated
T817 999-1003 IN denotes with
T818 1004-1011 JJ denotes various
T819 1012-1018 NN denotes agents
T820 1019-1028 VB denotes including
T821 1029-1037 NN denotes anti-CD3
T822 1037-1038 -COMMA- denotes ,
T823 1039-1048 NN denotes anti-CD28
T824 1048-1049 -COMMA- denotes ,
T825 1050-1068 NN denotes phytohemagglutinin
T826 1069-1070 -LRB- denotes (
T827 1070-1073 NN denotes PHA
T828 1073-1074 -RRB- denotes )
T829 1075-1078 CC denotes and
T830 1079-1086 JJ denotes several
T831 1087-1099 JJ denotes inflammatory
T832 1100-1109 NN denotes cytokines
T833 1110-1113 CC denotes and
T834 1114-1124 NN denotes chemokines
T835 1126-1131 NN denotes IL-17
T836 1132-1138 NN denotes levels
T837 1139-1143 VB denotes were
T838 1144-1154 VB denotes determined
T839 1155-1157 IN denotes by
T840 1158-1166 JJ denotes sandwich
T841 1167-1180 JJ denotes enzyme-linked
T842 1181-1194 JJ denotes immunosorbent
T843 1195-1200 NN denotes assay
T844 1201-1204 CC denotes and
T845 1205-1212 JJ denotes reverse
T846 1213-1237 NN denotes transcription–polymerase
T847 1238-1243 NN denotes chain
T848 1244-1252 NN denotes reaction
T849 1254-1257 DT denotes The
T850 1258-1268 NN denotes production
T851 1269-1271 IN denotes of
T852 1272-1277 NN denotes IL-17
T853 1278-1281 VB denotes was
T854 1282-1295 RB denotes significantly
T855 1296-1305 VB denotes increased
T856 1306-1308 IN denotes in
T857 1309-1314 NN denotes cells
T858 1315-1322 VB denotes treated
T859 1323-1327 IN denotes with
T860 1328-1336 JJ denotes anti-CD3
T861 1337-1345 NN denotes antibody
T862 1346-1350 IN denotes with
T863 1351-1353 CC denotes or
T864 1354-1361 IN denotes without
T865 1362-1371 NN denotes anti-CD28
T866 1372-1375 CC denotes and
T867 1376-1379 NN denotes PHA
T868 1380-1381 -LRB- denotes (
T869 1381-1382 NN denotes P
T870 1383-1384 SYM denotes <
T871 1385-1389 CD denotes 0.05
T872 1389-1390 -RRB- denotes )
T873 1392-1397 IN denotes Among
T874 1398-1404 VB denotes tested
T875 1405-1414 NN denotes cytokines
T876 1415-1418 CC denotes and
T877 1419-1429 NN denotes chemokines
T878 1429-1430 -COMMA- denotes ,
T879 1431-1436 NN denotes IL-15
T880 1436-1437 -COMMA- denotes ,
T881 1438-1446 NN denotes monocyte
T882 1447-1462 NN denotes chemoattractant
T883 1463-1472 NN denotes protein-1
T884 1473-1476 CC denotes and
T885 1477-1481 NN denotes IL-6
T886 1482-1493 VB denotes upregulated
T887 1494-1499 NN denotes IL-17
T888 1500-1510 NN denotes production
T889 1511-1512 -LRB- denotes (
T890 1512-1513 NN denotes P
T891 1514-1515 SYM denotes <
T892 1516-1520 CD denotes 0.05
T893 1520-1521 -RRB- denotes )
T894 1521-1522 -COMMA- denotes ,
T895 1523-1530 IN denotes whereas
T896 1531-1536 NN denotes tumor
T897 1537-1545 NN denotes necrosis
T898 1546-1554 NN denotes factor-α
T899 1554-1555 -COMMA- denotes ,
T900 1556-1561 NN denotes IL-1β
T901 1561-1562 -COMMA- denotes ,
T902 1563-1568 NN denotes IL-18
T903 1569-1571 CC denotes or
T904 1572-1584 VB denotes transforming
T905 1585-1591 NN denotes growth
T906 1592-1600 NN denotes factor-β
T907 1601-1604 VB denotes did
T908 1605-1608 RB denotes not
T909 1610-1615 NN denotes IL-17
T910 1616-1619 VB denotes was
T911 1620-1624 RB denotes also
T912 1625-1633 VB denotes detected
T913 1634-1636 IN denotes in
T914 1637-1640 DT denotes the
T915 1641-1645 NN denotes PBMC
T916 1646-1648 IN denotes of
T917 1649-1657 NN denotes patients
T918 1658-1662 IN denotes with
T919 1663-1677 NN denotes osteoarthritis
T920 1677-1678 -COMMA- denotes ,
T921 1679-1682 CC denotes but
T922 1683-1688 PRP-DOLLAR- denotes their
T923 1689-1699 NN denotes expression
T924 1700-1706 NN denotes levels
T925 1707-1711 VB denotes were
T926 1712-1716 RB denotes much
T927 1717-1722 JJ denotes lower
T928 1723-1727 IN denotes than
T929 1728-1733 DT denotes those
T930 1734-1736 IN denotes of
T931 1737-1739 NN denotes RA
T932 1740-1744 NN denotes PBMC
T933 1746-1754 JJ denotes Anti-CD3
T934 1755-1763 NN denotes antibody
T935 1764-1773 VB denotes activated
T936 1774-1777 DT denotes the
T937 1778-1786 NN denotes PI3K/Akt
T938 1787-1794 NN denotes pathway
T939 1794-1795 -COLON- denotes ;
T940 1796-1806 NN denotes activation
T941 1807-1809 IN denotes of
T942 1810-1814 DT denotes this
T943 1815-1822 NN denotes pathway
T944 1823-1831 VB denotes resulted
T945 1832-1834 IN denotes in
T946 1835-1836 DT denotes a
T947 1837-1847 JJ denotes pronounced
T948 1848-1860 NN denotes augmentation
T949 1861-1863 IN denotes of
T950 1864-1871 JJ denotes nuclear
T951 1872-1878 NN denotes factor
T952 1879-1881 NN denotes κB
T953 1882-1883 -LRB- denotes (
T954 1883-1888 NN denotes NF-κB
T955 1888-1889 -RRB- denotes )
T956 1890-1901 JJ denotes DNA-binding
T957 1902-1910 NN denotes activity
T958 1912-1917 NN denotes IL-17
T959 1918-1928 NN denotes production
T960 1929-1931 IN denotes by
T961 1932-1941 VB denotes activated
T962 1942-1944 NN denotes RA
T963 1945-1949 NN denotes PBMC
T964 1950-1952 VB denotes is
T965 1953-1963 RB denotes completely
T966 1964-1966 CC denotes or
T967 1967-1973 RB denotes partly
T968 1974-1981 VB denotes blocked
T969 1982-1984 IN denotes in
T970 1985-1988 DT denotes the
T971 1989-1997 NN denotes presence
T972 1998-2000 IN denotes of
T973 2001-2004 DT denotes the
T974 2005-2010 NN denotes NF-κB
T975 2011-2020 NN denotes inhibitor
T976 2021-2032 NN denotes pyrrolidine
T977 2033-2048 NN denotes dithiocarbamate
T978 2049-2052 CC denotes and
T979 2053-2056 DT denotes the
T980 2057-2065 NN denotes PI3K/Akt
T981 2066-2075 NN denotes inhibitor
T982 2076-2086 NN denotes wortmannin
T983 2087-2090 CC denotes and
T984 2091-2099 NN denotes LY294002
T985 2099-2100 -COMMA- denotes ,
T986 2101-2113 RB denotes respectively
T987 2115-2122 RB denotes However
T988 2122-2123 -COMMA- denotes ,
T989 2124-2134 NN denotes inhibition
T990 2135-2137 IN denotes of
T991 2138-2147 NN denotes activator
T992 2148-2157 NN denotes protein-1
T993 2158-2161 CC denotes and
T994 2162-2175 JJ denotes extracellular
T995 2176-2192 JJ denotes signal-regulated
T996 2193-2199 NN denotes kinase
T997 2200-2203 CD denotes 1/2
T998 2204-2207 VB denotes did
T999 2208-2211 RB denotes not
T1000 2212-2218 VB denotes affect
T1001 2219-2224 NN denotes IL-17
T1002 2225-2235 NN denotes production
T1003 2237-2242 DT denotes These
T1004 2243-2250 NN denotes results
T1005 2251-2258 VB denotes suggest
T1006 2259-2263 IN denotes that
T1007 2264-2270 NN denotes signal
T1008 2271-2283 NN denotes transduction
T1009 2284-2292 NN denotes pathways
T1010 2293-2302 JJ denotes dependent
T1011 2303-2305 IN denotes on
T1012 2306-2314 NN denotes PI3K/Akt
T1013 2315-2318 CC denotes and
T1014 2319-2324 NN denotes NF-κB
T1015 2325-2328 VB denotes are
T1016 2329-2337 VB denotes involved
T1017 2338-2340 IN denotes in
T1018 2341-2344 DT denotes the
T1019 2345-2359 NN denotes overproduction
T1020 2360-2362 IN denotes of
T1021 2363-2366 DT denotes the
T1022 2367-2370 JJ denotes key
T1023 2371-2383 JJ denotes inflammatory
T1024 2384-2392 NN denotes cytokine
T1025 2393-2398 NN denotes IL-17
T1026 2399-2401 IN denotes in
T1027 2402-2404 NN denotes RA
T2893 2420-2430 JJ denotes Rheumatoid
T2894 2431-2440 NN denotes arthritis
T2895 2441-2442 -LRB- denotes (
T2896 2442-2444 NN denotes RA
T2897 2444-2445 -RRB- denotes )
T2898 2446-2448 VB denotes is
T2899 2449-2462 VB denotes characterized
T2900 2463-2465 IN denotes by
T2901 2466-2479 NN denotes infiltrations
T2902 2480-2482 IN denotes of
T2903 2483-2494 NN denotes macrophages
T2904 2495-2498 CC denotes and
T2905 2499-2500 NN denotes T
T2906 2501-2506 NN denotes cells
T2907 2507-2511 IN denotes into
T2908 2512-2515 DT denotes the
T2909 2516-2521 NN denotes joint
T2910 2521-2522 -COMMA- denotes ,
T2911 2523-2526 CC denotes and
T2912 2527-2535 JJ denotes synovial
T2913 2536-2547 NN denotes hyperplasia
T2914 2549-2564 JJ denotes Proinflammatory
T2915 2565-2574 NN denotes cytokines
T2916 2575-2583 VB denotes released
T2917 2584-2588 IN denotes from
T2918 2589-2594 DT denotes these
T2919 2595-2600 NN denotes cells
T2920 2601-2604 VB denotes are
T2921 2605-2610 VB denotes known
T2922 2611-2613 TO denotes to
T2923 2614-2616 VB denotes be
T2924 2617-2626 JJ denotes important
T2925 2627-2629 IN denotes in
T2926 2630-2633 DT denotes the
T2927 2634-2645 NN denotes destruction
T2928 2646-2648 IN denotes of
T2929 2649-2655 NN denotes joints
T2930 2656-2658 IN denotes in
T2931 2659-2661 NN denotes RA
T2932 2662-2663 -LRB- denotes [
T2933 2663-2664 CD denotes 1
T2934 2664-2665 -RRB- denotes ]
T2935 2667-2670 DT denotes The
T2936 2671-2680 JJ denotes favorable
T2937 2681-2689 JJ denotes clinical
T2938 2690-2698 NN denotes benefits
T2939 2699-2707 VB denotes obtained
T2940 2708-2712 IN denotes with
T2941 2713-2723 NN denotes inhibitors
T2942 2724-2726 IN denotes of
T2943 2727-2732 NN denotes tumor
T2944 2733-2741 NN denotes necrosis
T2945 2742-2748 NN denotes factor
T2946 2749-2750 -LRB- denotes (
T2947 2750-2753 NN denotes TNF
T2948 2753-2754 -RRB- denotes )
T2949 2754-2756 NN denotes -α
T2950 2756-2757 -RRB- denotes )
T2951 2758-2761 CC denotes and
T2952 2762-2773 NN denotes interleukin
T2953 2774-2775 -LRB- denotes (
T2954 2775-2777 NN denotes IL
T2955 2777-2778 -RRB- denotes )
T2956 2778-2780 CD denotes -1
T2957 2781-2788 VB denotes suggest
T2958 2789-2793 IN denotes that
T2959 2794-2797 DT denotes the
T2960 2798-2806 NN denotes blockade
T2961 2807-2809 IN denotes of
T2962 2810-2813 JJ denotes key
T2963 2814-2826 JJ denotes inflammatory
T2964 2827-2836 NN denotes cytokines
T2965 2837-2840 VB denotes has
T2966 2841-2845 VB denotes been
T2967 2846-2849 DT denotes the
T2968 2850-2859 JJ denotes important
T2969 2860-2865 NN denotes issue
T2970 2866-2868 IN denotes in
T2971 2869-2872 DT denotes the
T2972 2873-2884 NN denotes development
T2973 2885-2887 IN denotes of
T2974 2888-2891 JJ denotes new
T2975 2892-2903 JJ denotes therapeutic
T2976 2904-2916 NN denotes applications
T2977 2917-2918 -LRB- denotes [
T2978 2918-2919 CD denotes 2
T2979 2919-2920 -RRB- denotes ]
T2980 2922-2923 DT denotes A
T2981 2924-2930 JJ denotes little
T2982 2931-2935 IN denotes over
T2983 2936-2937 DT denotes a
T2984 2938-2944 NN denotes decade
T2985 2945-2948 RB denotes ago
T2986 2948-2949 -COMMA- denotes ,
T2987 2950-2953 DT denotes the
T2988 2954-2961 NN denotes primacy
T2989 2962-2964 IN denotes of
T2990 2965-2966 NN denotes T
T2991 2967-2972 NN denotes cells
T2992 2973-2975 IN denotes in
T2993 2976-2979 DT denotes the
T2994 2980-2992 NN denotes pathogenesis
T2995 2993-2995 IN denotes of
T2996 2996-3006 JJ denotes autoimmune
T2997 3007-3014 NN denotes disease
T2998 3015-3019 JJ denotes such
T2999 3020-3022 IN denotes as
T3000 3023-3025 NN denotes RA
T3001 3026-3029 VB denotes was
T3002 3030-3040 JJ denotes undisputed
T3003 3041-3048 IN denotes because
T3004 3049-3053 PRP denotes they
T3005 3054-3057 VB denotes are
T3006 3058-3061 DT denotes the
T3007 3062-3069 JJ denotes largest
T3008 3070-3074 NN denotes cell
T3009 3075-3085 NN denotes population
T3010 3086-3098 VB denotes infiltrating
T3011 3099-3102 DT denotes the
T3012 3103-3111 NN denotes synovium
T3013 3113-3120 RB denotes However
T3014 3120-3121 -COMMA- denotes ,
T3015 3122-3123 DT denotes a
T3016 3124-3130 NN denotes series
T3017 3131-3133 IN denotes of
T3018 3134-3141 NN denotes studies
T3019 3142-3154 VB denotes demonstrated
T3020 3155-3162 NN denotes paucity
T3021 3163-3165 IN denotes of
T3022 3166-3167 NN denotes T
T3023 3168-3180 JJ denotes cell-derived
T3024 3181-3190 NN denotes cytokines
T3025 3191-3195 JJ denotes such
T3026 3196-3198 IN denotes as
T3027 3199-3203 NN denotes IL-2
T3028 3204-3207 CC denotes and
T3029 3208-3220 NN denotes interferon-γ
T3030 3221-3223 IN denotes in
T3031 3224-3227 DT denotes the
T3032 3228-3234 NN denotes joints
T3033 3235-3237 IN denotes of
T3034 3238-3240 NN denotes RA
T3035 3240-3241 -COMMA- denotes ,
T3036 3242-3249 IN denotes whereas
T3037 3250-3260 NN denotes macrophage
T3038 3261-3264 CC denotes and
T3039 3265-3275 NN denotes fibroblast
T3040 3276-3285 NN denotes cytokines
T3041 3286-3295 VB denotes including
T3042 3296-3300 NN denotes IL-1
T3043 3300-3301 -COMMA- denotes ,
T3044 3302-3306 NN denotes IL-6
T3045 3306-3307 -COMMA- denotes ,
T3046 3308-3313 NN denotes IL-15
T3047 3313-3314 -COMMA- denotes ,
T3048 3315-3320 NN denotes IL-18
T3049 3321-3324 CC denotes and
T3050 3325-3330 NN denotes TNF-α
T3051 3331-3335 VB denotes were
T3052 3336-3344 JJ denotes abundant
T3053 3345-3347 IN denotes in
T3054 3348-3358 JJ denotes rheumatoid
T3055 3359-3367 NN denotes synovium
T3056 3369-3373 DT denotes This
T3057 3374-3381 NN denotes paradox
T3058 3382-3385 VB denotes has
T3059 3386-3396 VB denotes questioned
T3060 3397-3400 DT denotes the
T3061 3401-3405 NN denotes role
T3062 3406-3408 IN denotes of
T3063 3409-3410 NN denotes T
T3064 3411-3416 NN denotes cells
T3065 3417-3419 IN denotes in
T3066 3420-3423 DT denotes the
T3067 3424-3436 NN denotes pathogenesis
T3068 3437-3439 IN denotes of
T3069 3440-3442 NN denotes RA
T3070 3443-3444 -LRB- denotes [
T3071 3444-3445 CD denotes 3
T3072 3445-3446 -RRB- denotes ]
T3073 3448-3455 IN denotes Because
T3074 3456-3458 PRP denotes we
T3075 3459-3463 VB denotes have
T3076 3464-3471 RB denotes already
T3077 3472-3484 VB denotes demonstrated
T3078 3485-3488 DT denotes the
T3079 3489-3497 VB denotes enhanced
T3080 3498-3511 NN denotes proliferation
T3081 3512-3514 IN denotes of
T3082 3515-3522 NN denotes antigen
T3083 3523-3531 JJ denotes specific
T3084 3532-3533 NN denotes T
T3085 3534-3539 NN denotes cells
T3086 3539-3540 -COMMA- denotes ,
T3087 3541-3551 RB denotes especially
T3088 3552-3554 TO denotes to
T3089 3555-3559 NN denotes type
T3090 3560-3562 CD denotes II
T3091 3563-3571 NN denotes collagen
T3092 3571-3572 -COMMA- denotes ,
T3093 3573-3576 CC denotes and
T3094 3577-3580 DT denotes the
T3095 3581-3588 NN denotes skewing
T3096 3589-3591 IN denotes of
T3097 3592-3593 NN denotes T
T3098 3594-3600 NN denotes helper
T3099 3601-3605 NN denotes type
T3100 3606-3607 CD denotes 1
T3101 3608-3609 -LRB- denotes (
T3102 3609-3612 NN denotes Th1
T3103 3612-3613 -RRB- denotes )
T3104 3614-3623 NN denotes cytokines
T3105 3624-3626 IN denotes in
T3106 3627-3629 NN denotes RA
T3107 3630-3631 -LRB- denotes [
T3108 3631-3632 CD denotes 4
T3109 3632-3633 -RRB- denotes ]
T3110 3633-3634 -COMMA- denotes ,
T3111 3635-3638 DT denotes the
T3112 3639-3643 NN denotes role
T3113 3644-3646 IN denotes of
T3114 3647-3648 NN denotes T
T3115 3649-3654 NN denotes cells
T3116 3655-3660 VB denotes needs
T3117 3661-3663 TO denotes to
T3118 3664-3666 VB denotes be
T3119 3667-3677 VB denotes elucidated
T3120 3678-3680 IN denotes in
T3121 3681-3690 JJ denotes different
T3122 3691-3698 NN denotes aspects
T3123 3700-3705 NN denotes IL-17
T3124 3706-3708 VB denotes is
T3125 3709-3712 CD denotes one
T3126 3713-3715 IN denotes of
T3127 3716-3719 DT denotes the
T3128 3720-3732 JJ denotes inflammatory
T3129 3733-3742 NN denotes cytokines
T3130 3743-3751 VB denotes secreted
T3131 3752-3758 RB denotes mainly
T3132 3759-3761 IN denotes by
T3133 3762-3771 VB denotes activated
T3134 3772-3773 NN denotes T
T3135 3774-3779 NN denotes cells
T3136 3779-3780 -COMMA- denotes ,
T3137 3781-3786 WDT denotes which
T3138 3787-3790 MD denotes can
T3139 3791-3797 VB denotes induce
T3140 3798-3802 NN denotes IL-6
T3141 3803-3806 CC denotes and
T3142 3807-3811 NN denotes IL-8
T3143 3812-3814 IN denotes by
T3144 3815-3826 NN denotes fibroblasts
T3145 3827-3828 -LRB- denotes [
T3146 3828-3829 CD denotes 5
T3147 3829-3830 -RRB- denotes ]
T3148 3832-3836 DT denotes This
T3149 3837-3845 NN denotes cytokine
T3150 3846-3848 VB denotes is
T3151 3849-3851 IN denotes of
T3152 3852-3860 NN denotes interest
T3153 3861-3864 IN denotes for
T3154 3865-3868 CD denotes two
T3155 3869-3874 JJ denotes major
T3156 3875-3882 NN denotes reasons
T3157 3882-3883 -COLON- denotes :
T3158 3884-3889 RB denotes first
T3159 3889-3890 -COMMA- denotes ,
T3160 3891-3900 RB denotes similarly
T3161 3901-3903 TO denotes to
T3162 3904-3909 NN denotes TNF-α
T3163 3910-3913 CC denotes and
T3164 3914-3918 NN denotes IL-1
T3165 3918-3919 -COMMA- denotes ,
T3166 3920-3925 NN denotes IL-17
T3167 3926-3929 VB denotes has
T3168 3930-3945 JJ denotes proinflammatory
T3169 3946-3956 NN denotes properties
T3170 3956-3957 -COLON- denotes ;
T3171 3958-3964 RB denotes second
T3172 3964-3965 -COMMA- denotes ,
T3173 3966-3968 PRP denotes it
T3174 3969-3971 VB denotes is
T3175 3972-3980 VB denotes produced
T3176 3981-3983 IN denotes by
T3177 3984-3985 NN denotes T
T3178 3986-3991 NN denotes cells
T3179 3992-3993 -LRB- denotes [
T3180 3993-3994 CD denotes 6
T3181 3994-3995 -RRB- denotes ]
T3182 3997-4003 JJ denotes Recent
T3183 4004-4016 NN denotes observations
T3184 4017-4029 VB denotes demonstrated
T3185 4030-4034 IN denotes that
T3186 4035-4040 NN denotes IL-17
T3187 4041-4044 MD denotes can
T3188 4045-4049 RB denotes also
T3189 4050-4058 VB denotes activate
T3190 4059-4071 JJ denotes osteoclastic
T3191 4072-4076 NN denotes bone
T3192 4077-4087 NN denotes resorption
T3193 4088-4090 IN denotes by
T3194 4091-4094 DT denotes the
T3195 4095-4104 NN denotes induction
T3196 4105-4107 IN denotes of
T3197 4108-4113 NN denotes RANKL
T3198 4114-4115 -LRB- denotes (
T3199 4115-4123 NN denotes receptor
T3200 4124-4133 NN denotes activator
T3201 4134-4136 IN denotes of
T3202 4137-4144 JJ denotes nuclear
T3203 4145-4151 NN denotes factor
T3204 4152-4154 NN denotes κB
T3205 4155-4156 -LRB- denotes [
T3206 4156-4161 NN denotes NF-κB
T3207 4161-4162 -RRB- denotes ]
T3208 4163-4169 NN denotes ligand
T3209 4169-4170 -RRB- denotes )
T3210 4170-4171 -COMMA- denotes ,
T3211 4172-4177 WDT denotes which
T3212 4178-4180 VB denotes is
T3213 4181-4189 VB denotes involved
T3214 4190-4192 IN denotes in
T3215 4193-4197 JJ denotes bony
T3216 4198-4205 NN denotes erosion
T3217 4206-4208 IN denotes in
T3218 4209-4211 NN denotes RA
T3219 4212-4213 -LRB- denotes [
T3220 4213-4214 CD denotes 7
T3221 4214-4215 -RRB- denotes ]
T3222 4217-4219 PRP denotes It
T3223 4220-4224 RB denotes also
T3224 4225-4235 VB denotes stimulates
T3225 4236-4239 DT denotes the
T3226 4240-4250 NN denotes production
T3227 4251-4253 IN denotes of
T3228 4254-4258 NN denotes IL-6
T3229 4259-4262 CC denotes and
T3230 4263-4271 NN denotes leukemia
T3231 4272-4282 JJ denotes inhibitory
T3232 4283-4289 NN denotes factor
T3233 4290-4292 IN denotes by
T3234 4293-4305 NN denotes synoviocytes
T3235 4305-4306 -COMMA- denotes ,
T3236 4307-4310 CC denotes and
T3237 4311-4313 IN denotes of
T3238 4314-4327 NN denotes prostaglandin
T3239 4328-4330 NN denotes E2
T3240 4331-4334 CC denotes and
T3241 4335-4341 JJ denotes nitric
T3242 4342-4347 NN denotes oxide
T3243 4348-4350 IN denotes by
T3244 4351-4363 NN denotes chondrocytes
T3245 4363-4364 -COMMA- denotes ,
T3246 4365-4368 CC denotes and
T3247 4369-4372 VB denotes has
T3248 4373-4376 DT denotes the
T3249 4377-4384 NN denotes ability
T3250 4385-4387 TO denotes to
T3251 4388-4401 VB denotes differentiate
T3252 4402-4405 CC denotes and
T3253 4406-4414 VB denotes activate
T3254 4415-4418 DT denotes the
T3255 4419-4428 JJ denotes dendritic
T3256 4429-4434 NN denotes cells
T3257 4435-4436 -LRB- denotes [
T3258 4436-4440 CD denotes 8-10
T3259 4440-4441 -RRB- denotes ]
T3260 4443-4449 NN denotes Levels
T3261 4450-4452 IN denotes of
T3262 4453-4458 NN denotes IL-17
T3263 4459-4461 IN denotes in
T3264 4462-4470 JJ denotes synovial
T3265 4471-4477 NN denotes fluids
T3266 4478-4482 VB denotes were
T3267 4483-4496 RB denotes significantly
T3268 4497-4503 JJ denotes higher
T3269 4504-4506 IN denotes in
T3270 4507-4515 NN denotes patients
T3271 4516-4520 IN denotes with
T3272 4521-4523 NN denotes RA
T3273 4524-4528 IN denotes than
T3274 4529-4531 IN denotes in
T3275 4532-4540 NN denotes patients
T3276 4541-4545 IN denotes with
T3277 4546-4560 NN denotes osteoarthritis
T3278 4561-4562 -LRB- denotes (
T3279 4562-4564 NN denotes OA
T3280 4564-4565 -RRB- denotes )
T3281 4565-4566 -COMMA- denotes ,
T3282 4567-4570 CC denotes and
T3283 4571-4573 PRP denotes it
T3284 4574-4577 VB denotes was
T3285 4578-4586 VB denotes produced
T3286 4587-4589 IN denotes by
T3287 4590-4594 JJ denotes CD4+
T3288 4595-4596 NN denotes T
T3289 4597-4602 NN denotes cells
T3290 4603-4605 IN denotes in
T3291 4606-4609 DT denotes the
T3292 4610-4618 NN denotes synovium
T3293 4619-4620 -LRB- denotes [
T3294 4620-4625 CD denotes 11,12
T3295 4625-4626 -RRB- denotes ]
T3296 4628-4633 NN denotes IL-15
T3297 4633-4634 -COMMA- denotes ,
T3298 4635-4643 VB denotes secreted
T3299 4644-4648 IN denotes from
T3300 4649-4658 VB denotes activated
T3301 4659-4670 NN denotes macrophages
T3302 4670-4671 -COMMA- denotes ,
T3303 4672-4675 VB denotes has
T3304 4676-4680 VB denotes been
T3305 4681-4689 VB denotes reported
T3306 4690-4692 TO denotes to
T3307 4693-4695 VB denotes be
T3308 4696-4698 DT denotes an
T3309 4699-4708 JJ denotes important
T3310 4709-4716 NN denotes trigger
T3311 4717-4719 IN denotes of
T3312 4720-4725 NN denotes IL-17
T3313 4726-4736 NN denotes production
T3314 4737-4739 IN denotes in
T3315 4740-4742 NN denotes RA
T3316 4743-4753 JJ denotes peripheral
T3317 4754-4759 NN denotes blood
T3318 4760-4771 JJ denotes mononuclear
T3319 4772-4777 NN denotes cells
T3320 4778-4779 -LRB- denotes (
T3321 4779-4783 NN denotes PBMC
T3322 4783-4784 -RRB- denotes )
T3323 4785-4787 IN denotes by
T3324 4788-4800 NN denotes cyclosporine
T3325 4801-4804 CC denotes and
T3326 4805-4812 NN denotes steroid
T3327 4813-4822 JJ denotes sensitive
T3328 4823-4831 NN denotes pathways
T3329 4832-4833 -LRB- denotes [
T3330 4833-4835 CD denotes 13
T3331 4835-4836 -RRB- denotes ]
T3332 4838-4846 RB denotes Recently
T3333 4846-4847 -COMMA- denotes ,
T3334 4848-4854 NNP denotes Happel
T3335 4855-4858 CC denotes and
T3336 4859-4869 NN denotes colleagues
T3337 4870-4874 RB denotes also
T3338 4875-4881 VB denotes showed
T3339 4882-4886 IN denotes that
T3340 4887-4892 NN denotes IL-23
T3341 4893-4898 MD denotes could
T3342 4899-4901 VB denotes be
T3343 4902-4904 DT denotes an
T3344 4905-4914 JJ denotes efficient
T3345 4915-4922 NN denotes trigger
T3346 4923-4925 IN denotes of
T3347 4926-4931 NN denotes IL-17
T3348 4932-4942 NN denotes production
T3349 4943-4947 IN denotes from
T3350 4948-4952 CC denotes both
T3351 4953-4957 JJ denotes CD4+
T3352 4958-4961 CC denotes and
T3353 4962-4966 JJ denotes CD8+
T3354 4967-4968 NN denotes T
T3355 4969-4974 NN denotes cells
T3356 4975-4976 -LRB- denotes [
T3357 4976-4978 CD denotes 14
T3358 4978-4979 -RRB- denotes ]
T3359 4981-4989 IN denotes Although
T3360 4990-4993 DT denotes the
T3361 4994-5006 NN denotes contribution
T3362 5007-5009 IN denotes of
T3363 5010-5015 NN denotes IL-17
T3364 5016-5018 IN denotes in
T3365 5019-5024 JJ denotes joint
T3366 5025-5037 NN denotes inflammation
T3367 5038-5040 IN denotes in
T3368 5041-5043 NN denotes RA
T3369 5044-5047 VB denotes has
T3370 5048-5052 VB denotes been
T3371 5053-5063 VB denotes documented
T3372 5064-5066 IN denotes in
T3373 5067-5074 JJ denotes earlier
T3374 5075-5082 NN denotes studies
T3375 5083-5084 -LRB- denotes [
T3376 5084-5092 CD denotes 12,15,16
T3377 5092-5093 -RRB- denotes ]
T3378 5093-5094 -COMMA- denotes ,
T3379 5095-5098 DT denotes the
T3380 5099-5112 JJ denotes intracellular
T3381 5113-5119 NN denotes signal
T3382 5120-5132 NN denotes transduction
T3383 5133-5140 NN denotes pathway
T3384 5141-5144 IN denotes for
T3385 5145-5150 NN denotes IL-17
T3386 5151-5161 NN denotes production
T3387 5162-5169 VB denotes remains
T3388 5170-5179 JJ denotes uncertain
T3389 5181-5183 IN denotes In
T3390 5184-5187 DT denotes the
T3391 5188-5195 JJ denotes present
T3392 5196-5201 NN denotes study
T3393 5202-5204 PRP denotes we
T3394 5205-5209 VB denotes used
T3395 5210-5217 JJ denotes various
T3396 5218-5225 NN denotes stimuli
T3397 5226-5228 TO denotes to
T3398 5229-5240 VB denotes investigate
T3399 5241-5246 NN denotes IL-17
T3400 5247-5257 NN denotes production
T3401 5258-5260 IN denotes in
T3402 5261-5265 NN denotes PBMC
T3403 5266-5268 IN denotes of
T3404 5269-5277 NN denotes patients
T3405 5278-5282 IN denotes with
T3406 5283-5285 NN denotes RA
T3407 5286-5289 CC denotes and
T3408 5290-5293 PRP-DOLLAR- denotes its
T3409 5294-5303 NN denotes signaling
T3410 5304-5316 NN denotes transduction
T3411 5317-5324 NN denotes pathway
T3412 5326-5328 PRP denotes We
T3413 5329-5334 VB denotes found
T3414 5335-5339 IN denotes that
T3415 5340-5343 DT denotes the
T3416 5344-5357 JJ denotes intracellular
T3417 5358-5367 NN denotes signaling
T3418 5368-5375 NN denotes pathway
T3419 5376-5385 VB denotes involving
T3420 5386-5402 NN denotes phosphoinositide
T3421 5403-5411 NN denotes 3-kinase
T3422 5412-5413 -LRB- denotes (
T3423 5413-5417 NN denotes PI3K
T3424 5417-5418 -RRB- denotes )
T3425 5418-5422 NN denotes /Akt
T3426 5423-5426 CC denotes and
T3427 5427-5432 NN denotes NF-κB
T3428 5433-5438 MD denotes might
T3429 5439-5441 VB denotes be
T3430 5442-5450 VB denotes involved
T3431 5451-5453 IN denotes in
T3432 5454-5457 DT denotes the
T3433 5458-5472 NN denotes overproduction
T3434 5473-5475 IN denotes of
T3435 5476-5479 DT denotes the
T3436 5480-5483 JJ denotes key
T3437 5484-5496 JJ denotes inflammatory
T3438 5497-5505 NN denotes cytokine
T3439 5506-5511 NN denotes IL-17
T3440 5512-5514 IN denotes in
T3441 5515-5517 NN denotes RA
T3442 5519-5524 DT denotes These
T3443 5525-5532 NN denotes results
T3444 5533-5538 MD denotes might
T3445 5539-5546 VB denotes provide
T3446 5547-5550 JJ denotes new
T3447 5551-5559 NN denotes insights
T3448 5560-5564 IN denotes into
T3449 5565-5568 DT denotes the
T3450 5569-5581 NN denotes pathogenesis
T3451 5582-5584 IN denotes of
T3452 5585-5587 NN denotes RA
T3453 5588-5591 CC denotes and
T3454 5592-5598 JJ denotes future
T3455 5599-5609 NN denotes directions
T3456 5610-5613 IN denotes for
T3457 5614-5617 JJ denotes new
T3458 5618-5629 JJ denotes therapeutic
T3459 5630-5640 NN denotes strategies
T3460 5641-5643 IN denotes in
T3461 5644-5646 NN denotes RA
T4881 5672-5680 NN denotes Patients
T4882 5681-5689 VB denotes Informed
T4883 5690-5697 NN denotes consent
T4884 5698-5701 VB denotes was
T4885 5702-5710 VB denotes obtained
T4886 5711-5715 IN denotes from
T4887 5716-5718 CD denotes 24
T4888 5719-5727 NN denotes patients
T4889 5728-5729 -LRB- denotes (
T4890 5729-5730 CD denotes 5
T4891 5731-5734 NN denotes men
T4892 5735-5738 CC denotes and
T4893 5739-5741 CD denotes 19
T4894 5742-5747 NN denotes women
T4895 5747-5748 -RRB- denotes )
T4896 5749-5753 IN denotes with
T4897 5754-5756 NN denotes RA
T4898 5757-5760 WP denotes who
T4899 5761-5770 VB denotes fulfilled
T4900 5771-5774 DT denotes the
T4901 5775-5779 CD denotes 1987
T4902 5780-5787 VB denotes revised
T4903 5788-5796 NN denotes criteria
T4904 5797-5799 IN denotes of
T4905 5800-5803 DT denotes the
T4906 5804-5812 NNP denotes American
T4907 5813-5820 NNP denotes College
T4908 5821-5823 IN denotes of
T4909 5824-5836 NNP denotes Rheumatology
T4910 5837-5838 -LRB- denotes (
T4911 5838-5846 RB denotes formerly
T4912 5847-5850 DT denotes the
T4913 5851-5859 NNP denotes American
T4914 5860-5870 NNP denotes Rheumatism
T4915 5871-5882 NNP denotes Association
T4916 5882-5883 -RRB- denotes )
T4917 5884-5885 -LRB- denotes [
T4918 5885-5887 CD denotes 17
T4919 5887-5888 -RRB- denotes ]
T4920 5890-5893 DT denotes The
T4921 5894-5897 NN denotes age
T4922 5898-5900 IN denotes of
T4923 5901-5904 DT denotes the
T4924 5905-5913 NN denotes patients
T4925 5914-5918 IN denotes with
T4926 5919-5921 NN denotes RA
T4927 5922-5925 VB denotes was
T4928 5926-5928 CD denotes 50
T4929 5929-5930 SYM denotes ±
T4930 5931-5932 CD denotes 8
T4931 5933-5934 -LRB- denotes (
T4932 5934-5938 NN denotes mean
T4933 5939-5940 CC denotes ±
T4934 5941-5944 NN denotes SEM
T4935 5944-5945 -RRB- denotes )
T4936 5946-5951 NN denotes years
T4937 5952-5953 -LRB- denotes (
T4938 5953-5958 NN denotes range
T4939 5959-5964 CD denotes 23–71
T4940 5965-5970 NN denotes years
T4941 5970-5971 -RRB- denotes )
T4942 5973-5976 DT denotes All
T4943 5977-5988 NN denotes medications
T4944 5989-5993 VB denotes were
T4945 5994-6001 VB denotes stopped
T4946 6002-6004 CD denotes 48
T4947 6005-6010 NN denotes hours
T4948 6011-6017 IN denotes before
T4949 6018-6023 NN denotes entry
T4950 6024-6026 TO denotes to
T4951 6027-6030 DT denotes the
T4952 6031-6036 NN denotes study
T4953 6038-6049 NN denotes Comparisons
T4954 6050-6054 VB denotes were
T4955 6055-6059 VB denotes made
T4956 6060-6064 IN denotes with
T4957 6065-6067 CD denotes 14
T4958 6068-6076 NN denotes patients
T4959 6077-6081 IN denotes with
T4960 6082-6084 NN denotes OA
T4961 6085-6086 -LRB- denotes (
T4962 6086-6087 CD denotes 3
T4963 6088-6091 NN denotes men
T4964 6092-6095 CC denotes and
T4965 6096-6098 CD denotes 11
T4966 6099-6104 NN denotes women
T4967 6104-6105 -RRB- denotes )
T4968 6106-6109 CC denotes and
T4969 6110-6114 IN denotes with
T4970 6115-6117 CD denotes 14
T4971 6118-6125 JJ denotes healthy
T4972 6126-6134 NN denotes controls
T4973 6135-6136 -LRB- denotes (
T4974 6136-6137 CD denotes 3
T4975 6138-6141 NN denotes men
T4976 6142-6145 CC denotes and
T4977 6146-6148 CD denotes 11
T4978 6149-6154 NN denotes women
T4979 6154-6155 -RRB- denotes )
T4980 6156-6159 WP denotes who
T4981 6160-6163 VB denotes had
T4982 6164-6166 DT denotes no
T4983 6167-6176 JJ denotes rheumatic
T4984 6177-6185 NN denotes diseases
T4985 6187-6190 DT denotes The
T4986 6191-6195 JJ denotes mean
T4987 6196-6200 NN denotes ages
T4988 6201-6203 IN denotes of
T4989 6204-6207 DT denotes the
T4990 6208-6216 NN denotes patients
T4991 6217-6221 IN denotes with
T4992 6222-6224 NN denotes OA
T4993 6225-6228 CC denotes and
T4994 6229-6232 DT denotes the
T4995 6233-6240 JJ denotes healthy
T4996 6241-6249 NN denotes controls
T4997 6250-6254 VB denotes were
T4998 6255-6257 CD denotes 50
T4999 6258-6259 CC denotes ±
T5000 6260-6261 CD denotes 8
T5001 6262-6267 NN denotes years
T5002 6268-6269 -LRB- denotes (
T5003 6269-6274 NN denotes range
T5004 6275-6280 CD denotes 34–68
T5005 6281-6286 NN denotes years
T5006 6286-6287 -RRB- denotes )
T5007 6288-6291 CC denotes and
T5008 6292-6294 CD denotes 30
T5009 6295-6296 CC denotes ±
T5010 6297-6298 CD denotes 6
T5011 6299-6304 NN denotes years
T5012 6305-6306 -LRB- denotes (
T5013 6306-6311 NN denotes range
T5014 6312-6317 CD denotes 24–57
T5015 6318-6323 NN denotes years
T5016 6323-6324 -RRB- denotes )
T5017 6326-6334 VB denotes Informed
T5018 6335-6342 NN denotes consent
T5019 6343-6346 VB denotes was
T5020 6347-6355 VB denotes obtained
T5021 6355-6356 -COMMA- denotes ,
T5022 6357-6360 CC denotes and
T5023 6361-6364 DT denotes the
T5024 6365-6373 NN denotes protocol
T5025 6374-6377 VB denotes was
T5026 6378-6386 VB denotes approved
T5027 6387-6389 IN denotes by
T5028 6390-6393 DT denotes the
T5029 6394-6402 NNP denotes Catholic
T5030 6403-6413 NNP denotes University
T5031 6414-6416 IN denotes of
T5032 6417-6422 NNP denotes Korea
T5033 6423-6428 NNP denotes Human
T5034 6429-6437 NNP denotes Research
T5035 6438-6444 NNP denotes Ethics
T5036 6445-6454 NNP denotes Committee
T5374 6457-6465 NN denotes Reagents
T5375 6466-6477 JJ denotes Recombinant
T5376 6478-6483 NN denotes IL-17
T5377 6483-6484 -COMMA- denotes ,
T5378 6485-6490 NN denotes IL-18
T5379 6490-6491 -COMMA- denotes ,
T5380 6492-6497 NN denotes IL-15
T5381 6497-6498 -COMMA- denotes ,
T5382 6499-6507 NN denotes monocyte
T5383 6508-6523 NN denotes chemoattractant
T5384 6524-6533 NN denotes protein-1
T5385 6534-6535 -LRB- denotes (
T5386 6535-6540 NN denotes MCP-1
T5387 6540-6541 -RRB- denotes )
T5388 6541-6542 -COMMA- denotes ,
T5389 6543-6553 NN denotes macrophage
T5390 6554-6566 JJ denotes inflammatory
T5391 6567-6574 NN denotes protein
T5392 6575-6576 -LRB- denotes (
T5393 6576-6579 NN denotes MIP
T5394 6579-6580 -RRB- denotes )
T5395 6580-6583 NN denotes -1α
T5396 6583-6584 -COMMA- denotes ,
T5397 6585-6591 NN denotes MIP-1β
T5398 6591-6592 -COMMA- denotes ,
T5399 6593-6597 NN denotes IL-6
T5400 6598-6601 CC denotes and
T5401 6602-6606 NN denotes IL-8
T5402 6607-6611 VB denotes were
T5403 6612-6621 VB denotes purchased
T5404 6622-6626 IN denotes from
T5405 6627-6628 NN denotes R
T5406 6629-6630 CC denotes &
T5407 6631-6632 NN denotes D
T5408 6633-6640 NN denotes systems
T5409 6641-6642 -LRB- denotes (
T5410 6642-6653 NNP denotes Minneapolis
T5411 6653-6654 -COMMA- denotes ,
T5412 6655-6657 NNP denotes MN
T5413 6657-6658 -COMMA- denotes ,
T5414 6659-6662 NNP denotes USA
T5415 6662-6663 -RRB- denotes )
T5416 6665-6676 JJ denotes Recombinant
T5417 6677-6689 VB denotes transforming
T5418 6690-6696 NN denotes growth
T5419 6697-6703 NN denotes factor
T5420 6704-6705 -LRB- denotes (
T5421 6705-6708 NN denotes TGF
T5422 6708-6709 -RRB- denotes )
T5423 6709-6711 NN denotes -β
T5424 6712-6715 VB denotes was
T5425 6716-6725 VB denotes purchased
T5426 6726-6730 IN denotes from
T5427 6731-6740 NNP denotes Peprotech
T5428 6741-6742 -LRB- denotes (
T5429 6742-6748 NNP denotes London
T5430 6748-6749 -COMMA- denotes ,
T5431 6750-6752 NNP denotes UK
T5432 6752-6753 -RRB- denotes )
T5433 6755-6766 JJ denotes Recombinant
T5434 6767-6772 NN denotes TNF-α
T5435 6773-6776 CC denotes and
T5436 6777-6781 NN denotes IL-1
T5437 6782-6786 VB denotes were
T5438 6787-6796 VB denotes purchased
T5439 6797-6801 IN denotes from
T5440 6802-6809 NNP denotes Endogen
T5441 6810-6814 NNP denotes Inc.
T5442 6815-6816 -LRB- denotes (
T5443 6816-6825 NNP denotes Cambridge
T5444 6825-6826 -COMMA- denotes ,
T5445 6827-6829 NNP denotes MA
T5446 6829-6830 -COMMA- denotes ,
T5447 6831-6834 NNP denotes USA
T5448 6834-6835 -RRB- denotes )
T5449 6837-6848 NN denotes Cyclosporin
T5450 6849-6850 NN denotes A
T5451 6851-6854 VB denotes was
T5452 6855-6863 VB denotes provided
T5453 6864-6866 IN denotes by
T5454 6867-6873 NNP denotes Sandos
T5455 6874-6878 NNP denotes Ltd.
T5456 6879-6880 -LRB- denotes (
T5457 6880-6885 NNP denotes Basel
T5458 6885-6886 -COMMA- denotes ,
T5459 6887-6898 NNP denotes Switzerland
T5460 6898-6899 -RRB- denotes )
T5461 6901-6919 NN denotes Phytohemagglutinin
T5462 6920-6921 -LRB- denotes (
T5463 6921-6924 NN denotes PHA
T5464 6924-6925 -RRB- denotes )
T5465 6925-6926 -COMMA- denotes ,
T5466 6927-6938 NN denotes pyrrolidine
T5467 6939-6954 NN denotes dithiocarbamate
T5468 6955-6956 -LRB- denotes (
T5469 6956-6960 NN denotes PDTC
T5470 6960-6961 -RRB- denotes )
T5471 6961-6962 -COMMA- denotes ,
T5472 6963-6972 NN denotes rapamycin
T5473 6972-6973 -COMMA- denotes ,
T5474 6974-6987 NN denotes dexamethasone
T5475 6988-6991 CC denotes and
T5476 6992-7000 NN denotes curcumin
T5477 7001-7005 VB denotes were
T5478 7006-7009 DT denotes all
T5479 7010-7018 VB denotes obtained
T5480 7019-7023 IN denotes from
T5481 7024-7027 DT denotes the
T5482 7028-7033 NNP denotes Sigma
T5483 7034-7042 NNP denotes Chemical
T5484 7043-7046 NNP denotes Co.
T5485 7047-7048 -LRB- denotes (
T5486 7048-7050 NNP denotes St
T5487 7051-7056 NNP denotes Louis
T5488 7056-7057 -COMMA- denotes ,
T5489 7058-7060 NNP denotes MA
T5490 7060-7061 -COMMA- denotes ,
T5491 7062-7065 NNP denotes USA
T5492 7065-7066 -RRB- denotes )
T5493 7068-7076 JJ denotes Anti-CD3
T5494 7077-7087 JJ denotes monoclonal
T5495 7088-7096 NN denotes antibody
T5496 7097-7100 CC denotes and
T5497 7101-7110 JJ denotes anti-CD28
T5498 7111-7121 JJ denotes monoclonal
T5499 7122-7130 NN denotes antibody
T5500 7131-7135 VB denotes were
T5501 7136-7144 VB denotes obtained
T5502 7145-7149 IN denotes from
T5503 7150-7152 NN denotes BD
T5504 7153-7164 NNP denotes Biosciences
T5505 7165-7166 -LRB- denotes (
T5506 7166-7169 NNP denotes San
T5507 7170-7175 NNP denotes Diego
T5508 7175-7176 -COMMA- denotes ,
T5509 7177-7179 NNP denotes CA
T5510 7179-7180 -COMMA- denotes ,
T5511 7181-7184 NNP denotes USA
T5512 7184-7185 -RRB- denotes )
T5513 7187-7195 NN denotes LY294002
T5514 7195-7196 -COMMA- denotes ,
T5515 7197-7205 NN denotes SB203580
T5516 7205-7206 -COMMA- denotes ,
T5517 7207-7212 NN denotes FK506
T5518 7212-7213 -COMMA- denotes ,
T5519 7214-7224 NN denotes wortmannin
T5520 7225-7228 CC denotes and
T5521 7229-7236 NN denotes PD98059
T5522 7237-7241 VB denotes were
T5523 7242-7250 VB denotes obtained
T5524 7251-7255 IN denotes from
T5525 7256-7266 NN denotes Calbiochem
T5526 7267-7268 -LRB- denotes (
T5527 7268-7278 NNP denotes Schwalbach
T5528 7278-7279 -COMMA- denotes ,
T5529 7280-7287 NNP denotes Germany
T5530 7287-7288 -RRB- denotes )
T6095 7291-7301 NN denotes Production
T6096 7302-7304 IN denotes of
T6097 7305-7310 NN denotes IL-17
T6098 7311-7313 IN denotes by
T6099 7314-7315 NN denotes T
T6100 7316-7320 NN denotes cell
T6101 7321-7329 NN denotes receptor
T6102 7330-7340 NN denotes activation
T6103 7340-7341 -COMMA- denotes ,
T6104 7342-7351 NN denotes cytokines
T6105 7352-7354 CC denotes or
T6106 7355-7365 NN denotes chemokines
T6107 7366-7370 NN denotes PBMC
T6108 7371-7375 VB denotes were
T6109 7376-7384 VB denotes prepared
T6110 7385-7389 IN denotes from
T6111 7390-7401 VB denotes heparinized
T6112 7402-7407 NN denotes blood
T6113 7408-7410 IN denotes by
T6114 7411-7425 JJ denotes Ficoll-Hypaque
T6115 7426-7427 -LRB- denotes (
T6116 7427-7433 NN denotes SG1077
T6117 7433-7434 -RRB- denotes )
T6118 7435-7451 JJ denotes density-gradient
T6119 7452-7466 NN denotes centrifugation
T6120 7468-7472 NN denotes Cell
T6121 7473-7481 NN denotes cultures
T6122 7482-7486 VB denotes were
T6123 7487-7496 VB denotes performed
T6124 7497-7499 IN denotes as
T6125 7500-7509 VB denotes described
T6126 7510-7520 RB denotes previously
T6127 7521-7522 -LRB- denotes [
T6128 7522-7524 CD denotes 18
T6129 7524-7525 -RRB- denotes ]
T6130 7527-7529 IN denotes In
T6131 7530-7535 NN denotes brief
T6132 7535-7536 -COMMA- denotes ,
T6133 7537-7540 DT denotes the
T6134 7541-7545 NN denotes cell
T6135 7546-7557 NN denotes suspensions
T6136 7558-7562 VB denotes were
T6137 7563-7571 VB denotes adjusted
T6138 7572-7574 TO denotes to
T6139 7575-7576 DT denotes a
T6140 7577-7590 NN denotes concentration
T6141 7591-7593 IN denotes of
T6142 7594-7600 NN denotes 106/ml
T6143 7601-7603 IN denotes in
T6144 7604-7608 NN denotes RPMI
T6145 7609-7613 CD denotes 1640
T6146 7614-7620 NN denotes medium
T6147 7621-7633 VB denotes supplemented
T6148 7634-7638 IN denotes with
T6149 7639-7641 CD denotes 10
T6150 7641-7642 NN denotes %
T6151 7643-7648 JJ denotes fetal
T6152 7649-7653 NN denotes calf
T6153 7654-7659 NN denotes serum
T6154 7659-7660 -COMMA- denotes ,
T6155 7661-7664 CD denotes 100
T6156 7665-7669 NN denotes U/ml
T6157 7670-7680 NN denotes penicillin
T6158 7680-7681 -COMMA- denotes ,
T6159 7682-7685 CD denotes 100
T6160 7686-7691 NN denotes mg/ml
T6161 7692-7704 NN denotes streptomycin
T6162 7705-7708 CC denotes and
T6163 7709-7710 CD denotes 2
T6164 7711-7713 NN denotes mM
T6165 7714-7725 NN denotes L-glutamine
T6166 7727-7731 NN denotes Cell
T6167 7732-7742 NN denotes suspension
T6168 7743-7744 -LRB- denotes (
T6169 7744-7745 CD denotes 1
T6170 7746-7748 NN denotes ml
T6171 7748-7749 -RRB- denotes )
T6172 7750-7753 VB denotes was
T6173 7754-7763 VB denotes dispensed
T6174 7764-7768 IN denotes into
T6175 7769-7776 JJ denotes 24-well
T6176 7777-7787 JJ denotes multi-well
T6177 7788-7794 NN denotes plates
T6178 7795-7796 -LRB- denotes (
T6179 7796-7800 NNP denotes Nunc
T6180 7800-7801 -COMMA- denotes ,
T6181 7802-7810 NNP denotes Roskilde
T6182 7810-7811 -COMMA- denotes ,
T6183 7812-7819 NNP denotes Denmark
T6184 7819-7820 -RRB- denotes )
T6185 7820-7821 -COMMA- denotes ,
T6186 7822-7825 CC denotes and
T6187 7826-7835 VB denotes incubated
T6188 7836-7839 IN denotes for
T6189 7840-7842 CD denotes 24
T6190 7843-7848 NN denotes hours
T6191 7849-7851 IN denotes at
T6192 7852-7856 NN denotes 37°C
T6193 7857-7859 IN denotes in
T6194 7860-7861 CD denotes 5
T6195 7861-7862 NN denotes %
T6196 7863-7866 NN denotes CO2
T6197 7868-7880 RB denotes Subsequently
T6198 7880-7881 -COMMA- denotes ,
T6199 7882-7889 JJ denotes various
T6200 7890-7904 NN denotes concentrations
T6201 7905-7907 IN denotes of
T6202 7908-7919 NN denotes cyclosporin
T6203 7920-7921 NN denotes A
T6204 7922-7923 -LRB- denotes (
T6205 7923-7929 CD denotes 10–500
T6206 7930-7935 NN denotes ng/ml
T6207 7935-7936 -RRB- denotes )
T6208 7937-7941 VB denotes were
T6209 7942-7947 VB denotes added
T6210 7948-7950 TO denotes to
T6211 7951-7954 DT denotes the
T6212 7955-7961 NN denotes medium
T6213 7962-7965 CC denotes and
T6214 7966-7971 NN denotes cells
T6215 7972-7976 VB denotes were
T6216 7977-7986 VB denotes incubated
T6217 7987-7990 IN denotes for
T6218 7991-7993 CD denotes 24
T6219 7994-7999 NN denotes hours
T6220 8001-8003 TO denotes To
T6221 8004-8008 DT denotes each
T6222 8009-8013 NN denotes well
T6223 8014-8017 VB denotes was
T6224 8018-8023 VB denotes added
T6225 8024-8029 NN denotes FK506
T6226 8029-8030 -COMMA- denotes ,
T6227 8031-8040 NN denotes rapamycin
T6228 8040-8041 -COMMA- denotes ,
T6229 8042-8050 NN denotes curcumin
T6230 8050-8051 -COMMA- denotes ,
T6231 8052-8056 NN denotes PDTC
T6232 8056-8057 -COMMA- denotes ,
T6233 8058-8066 NN denotes LY294002
T6234 8066-8067 -COMMA- denotes ,
T6235 8068-8076 NN denotes SB203580
T6236 8076-8077 -COMMA- denotes ,
T6237 8078-8085 NN denotes PD98059
T6238 8085-8086 -COMMA- denotes ,
T6239 8087-8100 NN denotes dexamethasone
T6240 8101-8103 CC denotes or
T6241 8104-8114 NN denotes wortmannin
T6242 8116-8121 IN denotes After
T6243 8122-8132 NN denotes incubation
T6244 8133-8136 IN denotes for
T6245 8137-8139 CD denotes 24
T6246 8140-8145 NN denotes hours
T6247 8146-8147 -LRB- denotes (
T6248 8147-8153 IN denotes unless
T6249 8154-8163 RB denotes otherwise
T6250 8164-8170 VB denotes stated
T6251 8170-8171 -RRB- denotes )
T6252 8171-8172 -COMMA- denotes ,
T6253 8173-8182 JJ denotes cell-free
T6254 8183-8188 NN denotes media
T6255 8189-8193 VB denotes were
T6256 8194-8203 VB denotes collected
T6257 8204-8207 CC denotes and
T6258 8208-8214 VB denotes stored
T6259 8215-8217 IN denotes at
T6260 8218-8223 NN denotes -20°C
T6261 8224-8229 IN denotes until
T6262 8230-8237 VB denotes assayed
T6263 8239-8242 DT denotes All
T6264 8243-8251 NN denotes cultures
T6265 8252-8256 VB denotes were
T6266 8257-8260 VB denotes set
T6267 8261-8263 RP denotes up
T6268 8264-8266 IN denotes in
T6269 8267-8277 NN denotes triplicate
T6270 8277-8278 -COMMA- denotes ,
T6271 8279-8282 CC denotes and
T6272 8283-8290 NN denotes results
T6273 8291-8294 VB denotes are
T6274 8295-8304 VB denotes expressed
T6275 8305-8307 IN denotes as
T6276 8308-8313 NN denotes means
T6277 8314-8315 CC denotes ±
T6278 8316-8319 NN denotes SEM
T6739 8322-8326 JJ denotes CD4+
T6740 8327-8333 NN denotes T-cell
T6741 8334-8343 NN denotes isolation
T6742 8344-8346 IN denotes by
T6743 8347-8351 NN denotes MACS
T6744 8352-8360 NN denotes Anti-CD4
T6745 8361-8371 NN denotes microbeads
T6746 8372-8376 VB denotes were
T6747 8377-8381 VB denotes used
T6748 8382-8393 RB denotes essentially
T6749 8394-8396 IN denotes as
T6750 8397-8408 VB denotes recommended
T6751 8409-8411 IN denotes by
T6752 8412-8415 DT denotes the
T6753 8416-8428 NN denotes manufacturer
T6754 8429-8430 -LRB- denotes (
T6755 8430-8438 NNP denotes Miltenyi
T6756 8438-8439 -RRB- denotes )
T6757 8440-8441 -LRB- denotes [
T6758 8441-8443 CD denotes 19
T6759 8443-8444 -RRB- denotes ]
T6760 8446-8450 NN denotes PBMC
T6761 8451-8455 VB denotes were
T6762 8456-8467 VB denotes resuspended
T6763 8468-8470 IN denotes in
T6764 8471-8473 CD denotes 80
T6765 8474-8476 NN denotes μl
T6766 8477-8479 IN denotes of
T6767 8480-8483 NNP denotes FBS
T6768 8484-8492 NN denotes staining
T6769 8493-8499 NN denotes buffer
T6770 8501-8509 JJ denotes Anti-CD4
T6771 8510-8520 NN denotes microbeads
T6772 8521-8522 -LRB- denotes (
T6773 8522-8524 CD denotes 20
T6774 8525-8527 NN denotes μl
T6775 8527-8528 -RRB- denotes )
T6776 8529-8533 VB denotes were
T6777 8534-8539 VB denotes added
T6778 8540-8543 CC denotes and
T6779 8544-8553 VB denotes incubated
T6780 8554-8557 IN denotes for
T6781 8558-8560 CD denotes 15
T6782 8561-8564 NN denotes min
T6783 8565-8567 IN denotes at
T6784 8568-8574 NN denotes 6–12°C
T6785 8576-8586 VB denotes Saturating
T6786 8587-8594 NN denotes amounts
T6787 8595-8597 IN denotes of
T6788 8598-8621 JJ denotes fluorochrome-conjugated
T6789 8622-8632 NN denotes antibodies
T6790 8633-8637 VB denotes were
T6791 8638-8643 VB denotes added
T6792 8644-8647 IN denotes for
T6793 8648-8649 DT denotes a
T6794 8650-8657 JJ denotes further
T6795 8658-8660 CD denotes 10
T6796 8661-8664 NN denotes min
T6797 8666-8671 NN denotes Cells
T6798 8672-8676 VB denotes were
T6799 8677-8684 VB denotes diluted
T6800 8685-8687 IN denotes in
T6801 8688-8691 CD denotes 2.5
T6802 8692-8694 NN denotes ml
T6803 8695-8697 IN denotes of
T6804 8698-8701 NNP denotes FBS
T6805 8702-8710 NN denotes staining
T6806 8711-8717 NN denotes buffer
T6807 8717-8718 -COMMA- denotes ,
T6808 8719-8727 VB denotes pelleted
T6809 8727-8728 -COMMA- denotes ,
T6810 8729-8740 VB denotes resuspended
T6811 8741-8743 IN denotes in
T6812 8744-8747 CD denotes 500
T6813 8748-8750 NN denotes μl
T6814 8751-8754 CC denotes and
T6815 8755-8767 RB denotes magnetically
T6816 8768-8777 VB denotes separated
T6817 8777-8778 -COMMA- denotes ,
T6818 8779-8786 RB denotes usually
T6819 8787-8789 IN denotes on
T6820 8790-8792 DT denotes an
T6821 8793-8801 NN denotes AutoMACS
T6822 8802-8808 NN denotes magnet
T6823 8809-8815 VB denotes fitted
T6824 8816-8820 IN denotes with
T6825 8821-8822 DT denotes a
T6826 8823-8827 NN denotes MACS
T6827 8828-8830 NN denotes MS
T6828 8831-8837 NN denotes column
T6829 8839-8851 JJ denotes Flow-through
T6830 8852-8855 CC denotes and
T6831 8856-8859 CD denotes two
T6832 8860-8861 CD denotes 1
T6833 8862-8864 NN denotes ml
T6834 8865-8871 NN denotes washes
T6835 8872-8876 VB denotes were
T6836 8877-8886 VB denotes collected
T6837 8887-8889 IN denotes as
T6838 8890-8893 DT denotes the
T6839 8894-8902 JJ denotes negative
T6840 8903-8911 NN denotes fraction
T6841 8913-8921 VB denotes Enriched
T6842 8922-8927 NN denotes cells
T6843 8928-8932 VB denotes were
T6844 8933-8942 VB denotes collected
T6845 8943-8945 IN denotes in
T6846 8946-8949 CD denotes two
T6847 8950-8953 CD denotes 0.5
T6848 8954-8956 NN denotes ml
T6849 8957-8965 NN denotes aliquots
T6850 8966-8970 IN denotes from
T6851 8971-8974 DT denotes the
T6852 8975-8981 NN denotes column
T6853 8982-8987 IN denotes after
T6854 8988-8995 NN denotes removal
T6855 8996-9000 IN denotes from
T6856 9001-9004 DT denotes the
T6857 9005-9011 NN denotes magnet
T6858 9013-9026 RB denotes Alternatively
T6859 9026-9027 -COMMA- denotes ,
T6860 9028-9033 NN denotes cells
T6861 9034-9041 VB denotes stained
T6862 9042-9046 IN denotes with
T6863 9047-9069 NN denotes anti-CD4–phycoerythrin
T6864 9070-9074 VB denotes were
T6865 9075-9081 VB denotes washed
T6866 9081-9082 -COMMA- denotes ,
T6867 9083-9095 RB denotes magnetically
T6868 9096-9103 VB denotes labeled
T6869 9104-9108 IN denotes with
T6870 9109-9127 JJ denotes anti-phycoerythrin
T6871 9128-9138 NN denotes microbeads
T6872 9139-9140 -LRB- denotes (
T6873 9140-9142 CD denotes 20
T6874 9143-9145 NN denotes μl
T6875 9146-9151 VB denotes added
T6876 9152-9154 TO denotes to
T6877 9155-9157 CD denotes 80
T6878 9158-9160 NN denotes μl
T6879 9161-9163 IN denotes of
T6880 9164-9168 NN denotes cell
T6881 9169-9179 NN denotes suspension
T6882 9179-9180 -COLON- denotes ;
T6883 9181-9183 CD denotes 15
T6884 9184-9187 NN denotes min
T6885 9187-9188 -COMMA- denotes ,
T6886 9189-9195 NN denotes 6–12°C
T6887 9195-9196 -RRB- denotes )
T6888 9196-9197 -COMMA- denotes ,
T6889 9198-9201 CC denotes and
T6890 9202-9214 RB denotes magnetically
T6891 9215-9224 VB denotes separated
T6892 9225-9227 IN denotes as
T6893 9228-9237 VB denotes described
T6894 9238-9243 RB denotes above
T6895 9245-9248 DT denotes The
T6896 9249-9255 NN denotes purity
T6897 9256-9258 IN denotes of
T6898 9259-9264 NN denotes cells
T6899 9265-9268 VB denotes was
T6900 9269-9277 VB denotes assessed
T6901 9278-9280 IN denotes by
T6902 9281-9285 NN denotes flow
T6903 9286-9296 JJ denotes cytometric
T6904 9297-9305 NN denotes analysis
T6905 9306-9308 IN denotes of
T6906 9309-9316 VB denotes stained
T6907 9317-9322 NN denotes cells
T6908 9323-9325 IN denotes on
T6909 9326-9327 DT denotes a
T6910 9328-9332 NNP denotes FACS
T6911 9333-9340 NNP denotes Vantage
T6912 9341-9347 NN denotes sorter
T6913 9349-9353 JJ denotes Most
T6914 9354-9355 -LRB- denotes (
T6915 9355-9359 JJ denotes more
T6916 9360-9364 IN denotes than
T6917 9365-9367 CD denotes 97
T6918 9367-9368 NN denotes %
T6919 9368-9369 -RRB- denotes )
T6920 9370-9372 IN denotes of
T6921 9373-9376 DT denotes the
T6922 9377-9385 VB denotes isolated
T6923 9386-9391 NN denotes cells
T6924 9392-9395 VB denotes had
T6925 9396-9399 DT denotes the
T6926 9400-9403 NN denotes CD4
T6927 9404-9405 NN denotes T
T6928 9406-9410 NN denotes cell
T6929 9411-9417 NN denotes marker
T7510 9420-9433 JJ denotes Enzyme-linked
T7511 9434-9447 JJ denotes immunosorbent
T7512 9448-9453 NN denotes assay
T7513 9454-9456 IN denotes of
T7514 9457-9462 NN denotes IL-17
T7515 9463-9468 NN denotes IL-17
T7516 9469-9471 IN denotes in
T7517 9472-9479 NN denotes culture
T7518 9480-9492 NN denotes supernatants
T7519 9493-9496 VB denotes was
T7520 9497-9505 VB denotes measured
T7521 9506-9508 IN denotes by
T7522 9509-9517 JJ denotes sandwich
T7523 9518-9531 JJ denotes enzyme-linked
T7524 9532-9545 JJ denotes immunosorbent
T7525 9546-9551 NN denotes assay
T7526 9552-9554 IN denotes as
T7527 9555-9564 VB denotes described
T7528 9565-9575 RB denotes previously
T7529 9576-9577 -LRB- denotes [
T7530 9577-9579 CD denotes 20
T7531 9579-9580 -RRB- denotes ]
T7532 9582-9584 IN denotes In
T7533 9585-9590 NN denotes brief
T7534 9590-9591 -COMMA- denotes ,
T7535 9592-9593 DT denotes a
T7536 9594-9601 JJ denotes 96-well
T7537 9602-9607 NN denotes plate
T7538 9608-9609 -LRB- denotes (
T7539 9609-9613 NN denotes Nunc
T7540 9613-9614 -RRB- denotes )
T7541 9615-9618 VB denotes was
T7542 9619-9625 VB denotes coated
T7543 9626-9630 IN denotes with
T7544 9631-9632 CD denotes 4
T7545 9633-9638 NN denotes μg/ml
T7546 9639-9649 JJ denotes monoclonal
T7547 9650-9660 NN denotes antibodies
T7548 9661-9668 IN denotes against
T7549 9669-9674 NN denotes IL-17
T7550 9675-9676 -LRB- denotes (
T7551 9676-9677 NN denotes R
T7552 9678-9679 CC denotes &
T7553 9680-9681 NNP denotes D
T7554 9682-9689 NNP denotes Systems
T7555 9689-9690 -RRB- denotes )
T7556 9691-9693 IN denotes at
T7557 9694-9697 NN denotes 4°C
T7558 9698-9707 RB denotes overnight
T7559 9709-9714 IN denotes After
T7560 9715-9723 VB denotes blocking
T7561 9724-9728 IN denotes with
T7562 9729-9747 JJ denotes phosphate-buffered
T7563 9748-9756 NN denotes saline/1
T7564 9756-9757 NN denotes %
T7565 9758-9764 JJ denotes bovine
T7566 9765-9770 NN denotes serum
T7567 9771-9778 NN denotes albumin
T7568 9779-9780 -LRB- denotes (
T7569 9780-9783 NN denotes BSA
T7570 9783-9784 -RRB- denotes )
T7571 9784-9789 CD denotes /0.05
T7572 9789-9790 NN denotes %
T7573 9791-9796 CD denotes Tween
T7574 9797-9799 CD denotes 20
T7575 9800-9803 IN denotes for
T7576 9804-9805 CD denotes 2
T7577 9806-9811 NN denotes hours
T7578 9812-9814 IN denotes at
T7579 9815-9819 NN denotes room
T7580 9820-9831 NN denotes temperature
T7581 9832-9833 -LRB- denotes (
T7582 9833-9840 NN denotes 22–25°C
T7583 9840-9841 -RRB- denotes )
T7584 9841-9842 -COMMA- denotes ,
T7585 9843-9847 NN denotes test
T7586 9848-9855 NN denotes samples
T7587 9856-9859 CC denotes and
T7588 9860-9863 DT denotes the
T7589 9864-9872 JJ denotes standard
T7590 9873-9884 JJ denotes recombinant
T7591 9885-9890 NN denotes IL-17
T7592 9891-9892 -LRB- denotes (
T7593 9892-9893 NN denotes R
T7594 9894-9895 CC denotes &
T7595 9896-9897 NNP denotes D
T7596 9898-9905 NNP denotes Systems
T7597 9905-9906 -RRB- denotes )
T7598 9907-9911 VB denotes were
T7599 9912-9917 VB denotes added
T7600 9918-9920 TO denotes to
T7601 9921-9924 DT denotes the
T7602 9925-9932 JJ denotes 96-well
T7603 9933-9938 NN denotes plate
T7604 9939-9942 CC denotes and
T7605 9943-9952 VB denotes incubated
T7606 9953-9955 IN denotes at
T7607 9956-9960 NN denotes room
T7608 9961-9972 NN denotes temperature
T7609 9973-9976 IN denotes for
T7610 9977-9978 CD denotes 2
T7611 9979-9984 NN denotes hours
T7612 9986-9992 NN denotes Plates
T7613 9993-9997 VB denotes were
T7614 9998-10004 VB denotes washed
T7615 10005-10009 CD denotes four
T7616 10010-10015 NN denotes times
T7617 10016-10020 IN denotes with
T7618 10021-10039 JJ denotes phosphate-buffered
T7619 10040-10052 NN denotes saline/Tween
T7620 10053-10055 CD denotes 20
T7621 10055-10056 -COMMA- denotes ,
T7622 10057-10060 CC denotes and
T7623 10061-10065 RB denotes then
T7624 10066-10075 VB denotes incubated
T7625 10076-10080 IN denotes with
T7626 10081-10084 CD denotes 500
T7627 10085-10090 NN denotes ng/ml
T7628 10091-10103 VB denotes biotinylated
T7629 10104-10109 NN denotes mouse
T7630 10110-10120 JJ denotes monoclonal
T7631 10121-10131 NN denotes antibodies
T7632 10132-10139 IN denotes against
T7633 10140-10145 NN denotes IL-17
T7634 10146-10147 -LRB- denotes (
T7635 10147-10148 NN denotes R
T7636 10149-10150 CC denotes &
T7637 10151-10152 NNP denotes D
T7638 10153-10160 NNP denotes Systems
T7639 10160-10161 -RRB- denotes )
T7640 10162-10165 IN denotes for
T7641 10166-10167 CD denotes 2
T7642 10168-10173 NN denotes hours
T7643 10174-10176 IN denotes at
T7644 10177-10181 NN denotes room
T7645 10182-10193 NN denotes temperature
T7646 10195-10200 IN denotes After
T7647 10201-10208 VB denotes washing
T7648 10208-10209 -COMMA- denotes ,
T7649 10210-10231 JJ denotes streptavidin–alkaline
T7650 10232-10253 JJ denotes phosphate–horseradish
T7651 10254-10264 NN denotes peroxidase
T7652 10265-10274 NN denotes conjugate
T7653 10275-10276 -LRB- denotes (
T7654 10276-10281 NN denotes Sigma
T7655 10281-10282 -RRB- denotes )
T7656 10283-10286 VB denotes was
T7657 10287-10296 VB denotes incubated
T7658 10297-10300 IN denotes for
T7659 10301-10302 CD denotes 2
T7660 10303-10308 NN denotes hours
T7661 10308-10309 -COMMA- denotes ,
T7662 10310-10314 RB denotes then
T7663 10315-10321 VB denotes washed
T7664 10322-10327 RB denotes again
T7665 10328-10331 CC denotes and
T7666 10332-10341 VB denotes incubated
T7667 10342-10346 IN denotes with
T7668 10347-10348 CD denotes 1
T7669 10349-10354 NN denotes mg/ml
T7670 10355-10368 NN denotes p-nitrophenyl
T7671 10369-10378 NN denotes phosphate
T7672 10379-10380 -LRB- denotes (
T7673 10380-10385 NN denotes Sigma
T7674 10385-10386 -RRB- denotes )
T7675 10387-10396 VB denotes dissolved
T7676 10397-10399 IN denotes in
T7677 10400-10414 NN denotes diethanolamine
T7678 10415-10416 -LRB- denotes (
T7679 10416-10421 NN denotes Sigma
T7680 10421-10422 -RRB- denotes )
T7681 10423-10425 TO denotes to
T7682 10426-10433 VB denotes develop
T7683 10434-10437 DT denotes the
T7684 10438-10443 NN denotes color
T7685 10444-10452 NN denotes reaction
T7686 10454-10457 DT denotes The
T7687 10458-10466 NN denotes reaction
T7688 10467-10470 VB denotes was
T7689 10471-10478 VB denotes stopped
T7690 10479-10481 IN denotes by
T7691 10482-10485 DT denotes the
T7692 10486-10494 NN denotes addition
T7693 10495-10497 IN denotes of
T7694 10498-10499 CD denotes 1
T7695 10500-10501 NN denotes M
T7696 10502-10506 NN denotes NaOH
T7697 10507-10510 CC denotes and
T7698 10511-10514 DT denotes the
T7699 10515-10522 JJ denotes optical
T7700 10523-10530 NN denotes density
T7701 10531-10533 IN denotes of
T7702 10534-10538 DT denotes each
T7703 10539-10543 NN denotes well
T7704 10544-10547 VB denotes was
T7705 10548-10552 VB denotes read
T7706 10553-10555 IN denotes at
T7707 10556-10559 CD denotes 405
T7708 10560-10562 NN denotes nm
T7709 10564-10567 DT denotes The
T7710 10568-10573 JJ denotes lower
T7711 10574-10579 NN denotes limit
T7712 10580-10582 IN denotes of
T7713 10583-10588 NN denotes IL-17
T7714 10589-10598 NN denotes detection
T7715 10599-10602 VB denotes was
T7716 10603-10605 CD denotes 10
T7717 10606-10611 NN denotes pg/ml
T7718 10613-10624 JJ denotes Recombinant
T7719 10625-10630 JJ denotes human
T7720 10631-10636 NN denotes IL-17
T7721 10637-10644 VB denotes diluted
T7722 10645-10647 IN denotes in
T7723 10648-10655 NN denotes culture
T7724 10656-10662 NN denotes medium
T7725 10663-10666 VB denotes was
T7726 10667-10671 VB denotes used
T7727 10672-10674 IN denotes as
T7728 10675-10676 DT denotes a
T7729 10677-10688 NN denotes calibration
T7730 10689-10697 NN denotes standard
T7731 10697-10698 -COMMA- denotes ,
T7732 10699-10706 VB denotes ranging
T7733 10707-10711 IN denotes from
T7734 10712-10714 CD denotes 10
T7735 10715-10717 TO denotes to
T7736 10718-10722 CD denotes 2000
T7737 10723-10728 NN denotes pg/ml
T7738 10730-10731 DT denotes A
T7739 10732-10740 JJ denotes standard
T7740 10741-10746 NN denotes curve
T7741 10747-10750 VB denotes was
T7742 10751-10756 VB denotes drawn
T7743 10757-10759 IN denotes by
T7744 10760-10768 VB denotes plotting
T7745 10769-10776 JJ denotes optical
T7746 10777-10784 NN denotes density
T7747 10785-10792 IN denotes against
T7748 10793-10796 DT denotes the
T7749 10797-10800 NN denotes log
T7750 10801-10803 IN denotes of
T7751 10804-10807 DT denotes the
T7752 10808-10821 NN denotes concentration
T7753 10822-10824 IN denotes of
T7754 10825-10836 JJ denotes recombinant
T7755 10837-10846 NN denotes cytokines
T7756 10846-10847 -COMMA- denotes ,
T7757 10848-10851 CC denotes and
T7758 10852-10856 VB denotes used
T7759 10857-10860 IN denotes for
T7760 10861-10874 NN denotes determination
T7761 10875-10877 IN denotes of
T7762 10878-10883 NN denotes IL-17
T7763 10884-10886 IN denotes in
T7764 10887-10891 NN denotes test
T7765 10892-10899 NN denotes samples
T9381 12496-12503 NN denotes Western
T9382 12504-12508 NN denotes blot
T9383 12509-12517 NN denotes analysis
T9384 12518-12520 IN denotes of
T9385 12521-12524 NN denotes Akt
T9386 12524-12525 -COMMA- denotes ,
T9387 12526-12540 VB denotes phosphorylated
T9388 12541-12544 NN denotes Akt
T9389 12545-12548 CC denotes and
T9390 12549-12554 NN denotes IκB-α
T9391 12555-12559 NN denotes PBMC
T9392 12560-12564 VB denotes were
T9393 12565-12574 VB denotes incubated
T9394 12575-12579 IN denotes with
T9395 12580-12588 NN denotes anti-CD3
T9396 12589-12590 -LRB- denotes (
T9397 12590-12592 CD denotes 10
T9398 12593-12598 NN denotes μg/ml
T9399 12598-12599 -RRB- denotes )
T9400 12600-12602 IN denotes in
T9401 12603-12606 DT denotes the
T9402 12607-12615 NN denotes presence
T9403 12616-12618 CC denotes or
T9404 12619-12626 NN denotes absence
T9405 12627-12629 IN denotes of
T9406 12630-12638 NN denotes LY294002
T9407 12639-12640 -LRB- denotes (
T9408 12640-12642 CD denotes 20
T9409 12643-12645 NN denotes μM
T9410 12645-12646 -RRB- denotes )
T9411 12648-12653 IN denotes After
T9412 12654-12664 NN denotes incubation
T9413 12665-12668 IN denotes for
T9414 12669-12670 CD denotes 1
T9415 12671-12675 NN denotes hour
T9416 12675-12676 -COMMA- denotes ,
T9417 12677-12682 JJ denotes whole
T9418 12683-12687 NN denotes cell
T9419 12688-12695 NN denotes lysates
T9420 12696-12700 VB denotes were
T9421 12701-12709 VB denotes prepared
T9422 12710-12714 IN denotes from
T9423 12715-12720 IN denotes about
T9424 12721-12724 CD denotes 107
T9425 12725-12730 NN denotes cells
T9426 12731-12733 IN denotes by
T9427 12734-12748 NN denotes homogenization
T9428 12749-12751 IN denotes in
T9429 12752-12755 DT denotes the
T9430 12756-12761 NN denotes lysis
T9431 12762-12768 NN denotes buffer
T9432 12768-12769 -COMMA- denotes ,
T9433 12770-12773 CC denotes and
T9434 12774-12785 VB denotes centrifuged
T9435 12786-12788 IN denotes at
T9436 12789-12795 CD denotes 14,000
T9437 12796-12802 NN denotes r.p.m.
T9438 12803-12804 -LRB- denotes (
T9439 12804-12810 CD denotes 19,000
T9440 12811-12812 NN denotes g
T9441 12812-12813 -RRB- denotes )
T9442 12814-12817 IN denotes for
T9443 12818-12820 CD denotes 15
T9444 12821-12824 NN denotes min
T9445 12826-12833 NN denotes Protein
T9446 12834-12848 NN denotes concentrations
T9447 12849-12851 IN denotes in
T9448 12852-12855 DT denotes the
T9449 12856-12868 NN denotes supernatants
T9450 12869-12873 VB denotes were
T9451 12874-12884 VB denotes determined
T9452 12885-12889 IN denotes with
T9453 12890-12893 DT denotes the
T9454 12894-12902 NNP denotes Bradford
T9455 12903-12909 NN denotes method
T9456 12910-12911 -LRB- denotes (
T9457 12911-12918 NNP denotes Bio-Rad
T9458 12918-12919 -COMMA- denotes ,
T9459 12920-12928 NNP denotes Hercules
T9460 12928-12929 -COMMA- denotes ,
T9461 12930-12932 NNP denotes CA
T9462 12932-12933 -COMMA- denotes ,
T9463 12934-12937 NNP denotes USA
T9464 12937-12938 -RRB- denotes )
T9465 12940-12947 NN denotes Protein
T9466 12948-12955 NN denotes samples
T9467 12956-12960 VB denotes were
T9468 12961-12970 VB denotes separated
T9469 12971-12973 IN denotes by
T9470 12974-12976 CD denotes 10
T9471 12976-12977 NN denotes %
T9472 12978-12986 NN denotes SDS–PAGE
T9473 12987-12990 CC denotes and
T9474 12991-13002 VB denotes transferred
T9475 13003-13005 TO denotes to
T9476 13006-13007 DT denotes a
T9477 13008-13022 NN denotes nitrocellulose
T9478 13023-13031 NN denotes membrane
T9479 13032-13033 -LRB- denotes (
T9480 13033-13041 NNP denotes Amersham
T9481 13042-13051 NNP denotes Pharmacia
T9482 13052-13059 NNP denotes Biotech
T9483 13059-13060 -COMMA- denotes ,
T9484 13061-13068 NNP denotes Uppsala
T9485 13068-13069 -COMMA- denotes ,
T9486 13070-13076 NNP denotes Sweden
T9487 13076-13077 -RRB- denotes )
T9488 13079-13082 IN denotes For
T9489 13083-13090 JJ denotes western
T9490 13091-13104 NN denotes hybridization
T9491 13104-13105 -COMMA- denotes ,
T9492 13106-13114 NN denotes membrane
T9493 13115-13118 VB denotes was
T9494 13119-13131 VB denotes preincubated
T9495 13132-13136 IN denotes with
T9496 13137-13140 CD denotes 0.1
T9497 13140-13141 NN denotes %
T9498 13142-13149 VB denotes skimmed
T9499 13150-13154 NN denotes milk
T9500 13155-13157 IN denotes in
T9501 13158-13163 NN denotes TBS-T
T9502 13164-13170 NN denotes buffer
T9503 13171-13172 -LRB- denotes (
T9504 13172-13175 CD denotes 0.1
T9505 13175-13176 NN denotes %
T9506 13177-13182 CD denotes Tween
T9507 13183-13185 CD denotes 20
T9508 13186-13188 IN denotes in
T9509 13189-13202 JJ denotes Tris-buffered
T9510 13203-13209 NN denotes saline
T9511 13209-13210 -RRB- denotes )
T9512 13211-13213 IN denotes at
T9513 13214-13218 NN denotes room
T9514 13219-13230 NN denotes temperature
T9515 13231-13234 IN denotes for
T9516 13235-13236 CD denotes 2
T9517 13237-13242 NN denotes hours
T9518 13242-13243 -COMMA- denotes ,
T9519 13244-13248 RB denotes then
T9520 13249-13256 JJ denotes primary
T9521 13257-13267 NN denotes antibodies
T9522 13268-13275 IN denotes against
T9523 13276-13279 NNP denotes Akt
T9524 13279-13280 -COMMA- denotes ,
T9525 13281-13295 VB denotes phosphorylated
T9526 13296-13299 NN denotes Akt
T9527 13300-13303 CC denotes and
T9528 13304-13309 NN denotes IκB-α
T9529 13310-13311 -LRB- denotes (
T9530 13311-13315 NNP denotes Cell
T9531 13316-13325 NNP denotes Signaling
T9532 13326-13336 NNP denotes Technology
T9533 13337-13341 NNP denotes Inc.
T9534 13341-13342 -COMMA- denotes ,
T9535 13343-13350 NNP denotes Beverly
T9536 13350-13351 -COMMA- denotes ,
T9537 13352-13354 NNP denotes MA
T9538 13354-13355 -COMMA- denotes ,
T9539 13356-13359 NNP denotes USA
T9540 13359-13360 -RRB- denotes )
T9541 13360-13361 -COMMA- denotes ,
T9542 13362-13369 VB denotes diluted
T9543 13370-13371 CD denotes 1
T9544 13371-13372 -COLON- denotes :
T9545 13372-13376 CD denotes 1000
T9546 13377-13379 IN denotes in
T9547 13380-13381 CD denotes 5
T9548 13381-13382 NN denotes %
T9549 13383-13392 NN denotes BSA/TBS-T
T9550 13392-13393 -COMMA- denotes ,
T9551 13394-13398 VB denotes were
T9552 13399-13404 VB denotes added
T9553 13405-13408 CC denotes and
T9554 13409-13418 VB denotes incubated
T9555 13419-13428 RB denotes overnight
T9556 13429-13431 IN denotes at
T9557 13432-13435 NN denotes 4°C
T9558 13437-13442 IN denotes After
T9559 13443-13450 VB denotes washing
T9560 13451-13455 CD denotes four
T9561 13456-13461 NN denotes times
T9562 13462-13466 IN denotes with
T9563 13467-13472 NN denotes TBS-T
T9564 13472-13473 -COMMA- denotes ,
T9565 13474-13485 JJ denotes horseradish
T9566 13486-13507 JJ denotes peroxidase-conjugated
T9567 13508-13517 JJ denotes secondary
T9568 13518-13528 NN denotes antibodies
T9569 13529-13533 VB denotes were
T9570 13534-13539 VB denotes added
T9571 13540-13543 CC denotes and
T9572 13544-13551 VB denotes allowed
T9573 13552-13554 TO denotes to
T9574 13555-13563 VB denotes incubate
T9575 13564-13567 IN denotes for
T9576 13568-13569 CD denotes 1
T9577 13570-13574 NN denotes hour
T9578 13575-13577 IN denotes at
T9579 13578-13582 NN denotes room
T9580 13583-13594 NN denotes temperature
T9581 13596-13601 IN denotes After
T9582 13602-13607 NN denotes TBS-T
T9583 13608-13615 NN denotes washing
T9584 13615-13616 -COMMA- denotes ,
T9585 13617-13627 VB denotes hybridized
T9586 13628-13633 NN denotes bands
T9587 13634-13638 VB denotes were
T9588 13639-13647 VB denotes detected
T9589 13648-13652 IN denotes with
T9590 13653-13656 DT denotes the
T9591 13657-13665 VB denotes enhanced
T9592 13666-13683 NN denotes chemiluminescence
T9593 13684-13685 -LRB- denotes (
T9594 13685-13688 NN denotes ECL
T9595 13688-13689 -RRB- denotes )
T9596 13690-13699 NN denotes detection
T9597 13700-13703 NN denotes kit
T9598 13704-13707 CC denotes and
T9599 13708-13721 NN denotes Hyperfilm-ECL
T9600 13722-13730 NN denotes reagents
T9601 13731-13732 -LRB- denotes (
T9602 13732-13740 NNP denotes Amersham
T9603 13741-13750 NNP denotes Pharmacia
T9604 13750-13751 -RRB- denotes )
T10190 13754-13757 NN denotes Gel
T10191 13758-13772 JJ|NN denotes mobility-shift
T10192 13773-13778 NN denotes assay
T10193 13779-13781 IN denotes of
T10194 13782-13787 NN denotes NF-κB
T10195 13788-13795 NN denotes binding
T10196 13796-13800 NN denotes site
T10197 13801-13808 JJ denotes Nuclear
T10198 13809-13817 NN denotes proteins
T10199 13818-13822 VB denotes were
T10200 13823-13832 VB denotes extracted
T10201 13833-13837 IN denotes from
T10202 13838-13843 IN denotes about
T10203 13844-13845 CD denotes 5
T10204 13846-13847 SYM denotes ×
T10205 13848-13851 CD denotes 106
T10206 13852-13856 NN denotes PBMC
T10207 13858-13873 NN denotes Oligonucleotide
T10208 13874-13880 NN denotes probes
T10209 13881-13893 VB denotes encompassing
T10210 13894-13897 DT denotes the
T10211 13898-13903 NN denotes NF-κB
T10212 13904-13911 NN denotes binding
T10213 13912-13916 NN denotes site
T10214 13917-13919 IN denotes of
T10215 13920-13923 DT denotes the
T10216 13924-13929 JJ denotes human
T10217 13930-13935 NN denotes IL-17
T10218 13936-13944 NN denotes promoter
T10219 13945-13946 -LRB- denotes (
T10220 13946-13952 NN denotes 5'-ATG
T10221 13953-13956 NN denotes ACC
T10222 13957-13960 NN denotes TGG
T10223 13961-13964 NN denotes AAA
T10224 13965-13968 NN denotes TAC
T10225 13969-13972 NN denotes CCA
T10226 13973-13976 NN denotes AAA
T10227 13977-13982 NN denotes TTC-3
T10228 13982-13983 -DQE- denotes '
T10229 13983-13984 -RRB- denotes )
T10230 13985-13989 VB denotes were
T10231 13990-13999 VB denotes generated
T10232 14000-14002 IN denotes by
T10233 14003-14009 JJ denotes 5'-end
T10234 14010-14018 NN denotes labeling
T10235 14019-14021 IN denotes of
T10236 14022-14025 DT denotes the
T10237 14026-14031 NN denotes sense
T10238 14032-14038 NN denotes strand
T10239 14039-14043 IN denotes with
T10240 14044-14045 -LRB- denotes [
T10241 14045-14050 NN denotes γ-32P
T10242 14050-14051 -RRB- denotes ]
T10243 14051-14055 NN denotes dATP
T10244 14056-14057 -LRB- denotes (
T10245 14057-14065 NNP denotes Amersham
T10246 14066-14075 NNP denotes Pharmacia
T10247 14075-14076 -RRB- denotes )
T10248 14077-14080 CC denotes and
T10249 14081-14083 NN denotes T4
T10250 14084-14098 NN denotes polynucleotide
T10251 14099-14105 NN denotes kinase
T10252 14106-14107 -LRB- denotes (
T10253 14107-14113 NN denotes TaKaRa
T10254 14113-14114 -RRB- denotes )
T10255 14116-14130 JJ denotes Unincorporated
T10256 14131-14142 NN denotes nucleotides
T10257 14143-14147 VB denotes were
T10258 14148-14155 VB denotes removed
T10259 14156-14158 IN denotes by
T10260 14159-14166 NN denotes NucTrap
T10261 14167-14172 NN denotes probe
T10262 14173-14185 NN denotes purification
T10263 14186-14193 NN denotes columns
T10264 14194-14195 -LRB- denotes (
T10265 14195-14205 NNP denotes Stratagene
T10266 14205-14206 -COMMA- denotes ,
T10267 14207-14209 NNP denotes La
T10268 14210-14215 NNP denotes Jolla
T10269 14215-14216 -COMMA- denotes ,
T10270 14217-14219 NNP denotes CA
T10271 14219-14220 -COMMA- denotes ,
T10272 14221-14224 NNP denotes USA
T10273 14224-14225 -RRB- denotes )
T10274 14227-14234 JJ denotes Nuclear
T10275 14235-14243 NN denotes extracts
T10276 14244-14245 -LRB- denotes (
T10277 14245-14246 CD denotes 2
T10278 14247-14249 NN denotes μg
T10279 14250-14252 IN denotes of
T10280 14253-14260 NN denotes protein
T10281 14260-14261 -RRB- denotes )
T10282 14262-14266 VB denotes were
T10283 14267-14276 VB denotes incubated
T10284 14277-14281 IN denotes with
T10285 14282-14294 VB denotes radiolabeled
T10286 14295-14298 NN denotes DNA
T10287 14299-14305 NN denotes probes
T10288 14306-14307 -LRB- denotes (
T10289 14307-14309 CD denotes 10
T10290 14310-14312 NN denotes ng
T10291 14312-14313 -COLON- denotes ;
T10292 14314-14321 CD denotes 100,000
T10293 14322-14328 NN denotes c.p.m.
T10294 14328-14329 -RRB- denotes )
T10295 14330-14333 IN denotes for
T10296 14334-14336 CD denotes 30
T10297 14337-14340 NN denotes min
T10298 14341-14343 IN denotes at
T10299 14344-14348 NN denotes room
T10300 14349-14360 NN denotes temperature
T10301 14361-14363 IN denotes in
T10302 14364-14366 CD denotes 20
T10303 14367-14369 NN denotes μl
T10304 14370-14372 IN denotes of
T10305 14373-14380 NN denotes binding
T10306 14381-14387 NN denotes buffer
T10307 14388-14398 VB denotes consisting
T10308 14399-14401 IN denotes of
T10309 14402-14404 CD denotes 20
T10310 14405-14407 NN denotes mM
T10311 14408-14416 NN denotes Tris-HCl
T10312 14416-14417 -COMMA- denotes ,
T10313 14418-14420 NN denotes pH
T10314 14421-14424 CD denotes 7.9
T10315 14424-14425 -COMMA- denotes ,
T10316 14426-14428 CD denotes 50
T10317 14429-14431 NN denotes mM
T10318 14432-14435 NN denotes KCl
T10319 14435-14436 -COMMA- denotes ,
T10320 14437-14438 CD denotes 1
T10321 14439-14441 NN denotes mM
T10322 14442-14456 NN denotes dithiothreitol
T10323 14456-14457 -COMMA- denotes ,
T10324 14458-14461 CD denotes 0.5
T10325 14462-14464 NN denotes mM
T10326 14465-14469 NN denotes EDTA
T10327 14469-14470 -COMMA- denotes ,
T10328 14471-14472 CD denotes 5
T10329 14472-14473 NN denotes %
T10330 14474-14482 NN denotes glycerol
T10331 14482-14483 -COMMA- denotes ,
T10332 14484-14485 CD denotes 1
T10333 14486-14491 NN denotes mg/ml
T10334 14492-14495 NN denotes BSA
T10335 14495-14496 -COMMA- denotes ,
T10336 14497-14500 CD denotes 0.2
T10337 14500-14501 NN denotes %
T10338 14502-14509 NN denotes Nonidet
T10339 14510-14513 NN denotes P40
T10340 14514-14517 CC denotes and
T10341 14518-14520 CD denotes 50
T10342 14521-14526 NN denotes ng/μl
T10343 14527-14531 NN denotes poly
T10344 14531-14532 -LRB- denotes (
T10345 14532-14537 NN denotes dI-dC
T10346 14537-14538 -RRB- denotes )
T10347 14540-14547 NN denotes Samples
T10348 14548-14552 VB denotes were
T10349 14553-14562 VB denotes subjected
T10350 14563-14565 TO denotes to
T10351 14566-14581 NN denotes electrophoresis
T10352 14582-14584 IN denotes on
T10353 14585-14598 JJ denotes nondenaturing
T10354 14599-14600 CD denotes 5
T10355 14600-14601 NN denotes %
T10356 14602-14616 NN denotes polyacrylamide
T10357 14617-14621 NN denotes gels
T10358 14622-14624 IN denotes in
T10359 14625-14628 CD denotes 0.5
T10360 14629-14630 SYM denotes ×
T10361 14631-14647 NN denotes Tris-borate-EDTA
T10362 14648-14654 NN denotes buffer
T10363 14655-14656 -LRB- denotes (
T10364 14656-14658 NN denotes pH
T10365 14659-14662 CD denotes 8.0
T10366 14662-14663 -RRB- denotes )
T10367 14664-14666 IN denotes at
T10368 14667-14670 CD denotes 100
T10369 14671-14673 NNP denotes V.
T10370 14674-14678 NNP denotes Gels
T10371 14679-14683 VB denotes were
T10372 14684-14689 VB denotes dried
T10373 14690-14695 IN denotes under
T10374 14696-14702 NN denotes vacuum
T10375 14703-14706 CC denotes and
T10376 14707-14714 VB denotes exposed
T10377 14715-14717 TO denotes to
T10378 14718-14723 VB denotes Kodak
T10379 14724-14730 NN denotes X-OMAT
T10380 14731-14735 NN denotes film
T10381 14736-14738 IN denotes at
T10382 14739-14744 NN denotes -70°C
T10383 14745-14749 IN denotes with
T10384 14750-14762 VB denotes intensifying
T10385 14763-14770 NN denotes screens
T10386 14772-14778 NN denotes Rabbit
T10387 14779-14789 JJ denotes polyclonal
T10388 14790-14800 NN denotes antibodies
T10389 14801-14808 IN denotes against
T10390 14809-14814 NN denotes NF-κB
T10391 14815-14823 NN denotes subunits
T10392 14824-14827 NN denotes p50
T10393 14827-14828 -COMMA- denotes ,
T10394 14829-14832 NN denotes p65
T10395 14833-14836 CC denotes and
T10396 14837-14842 NN denotes c-Rel
T10397 14843-14847 VB denotes were
T10398 14848-14852 IN denotes from
T10399 14853-14858 NNP denotes Santa
T10400 14859-14863 NNP denotes Cruz
T10401 14864-14877 NNP denotes Biotechnology
T10402 14878-14879 -LRB- denotes (
T10403 14879-14884 NNP denotes Santa
T10404 14885-14889 NNP denotes Cruz
T10405 14889-14890 -COMMA- denotes ,
T10406 14891-14893 NNP denotes CA
T10407 14893-14894 -COMMA- denotes ,
T10408 14895-14898 NNP denotes USA
T10409 14898-14899 -RRB- denotes )
T10825 14902-14906 NN denotes Cell
T10826 14907-14916 NN denotes viability
T10827 14917-14918 -LRB- denotes (
T10828 14918-14924 NN denotes Trypan
T10829 14925-14929 JJ denotes blue
T10830 14930-14933 NN denotes dye
T10831 14934-14943 NN denotes exclusion
T10832 14944-14949 NN denotes assay
T10833 14949-14950 -RRB- denotes )
T10834 14951-14954 IN denotes For
T10835 14955-14959 NN denotes cell
T10836 14960-14969 NN denotes viability
T10837 14970-14976 NN denotes assays
T10838 14976-14977 -COMMA- denotes ,
T10839 14978-14981 DT denotes the
T10840 14982-14988 NN denotes trypan
T10841 14989-14993 JJ denotes blue
T10842 14994-14997 NN denotes dye
T10843 14998-15007 NN denotes exclusion
T10844 15008-15014 NN denotes method
T10845 15015-15018 VB denotes was
T10846 15019-15023 VB denotes used
T10847 15024-15026 TO denotes to
T10848 15027-15035 VB denotes evaluate
T10849 15036-15039 DT denotes the
T10850 15040-15049 NN denotes potential
T10851 15050-15052 IN denotes of
T10852 15053-15059 JJ denotes direct
T10853 15060-15069 JJ denotes cytotoxic
T10854 15070-15076 NN denotes effect
T10855 15077-15079 IN denotes of
T10856 15080-15090 NN denotes inhibitors
T10857 15091-15093 IN denotes on
T10858 15094-15099 NN denotes cells
T10859 15101-15106 IN denotes After
T10860 15107-15117 NN denotes incubation
T10861 15118-15121 IN denotes for
T10862 15122-15124 CD denotes 24
T10863 15125-15130 NN denotes hours
T10864 15130-15131 -COMMA- denotes ,
T10865 15132-15135 DT denotes the
T10866 15136-15141 NN denotes cells
T10867 15142-15146 VB denotes were
T10868 15147-15156 VB denotes harvested
T10869 15157-15160 CC denotes and
T10870 15161-15164 DT denotes the
T10871 15165-15175 NN denotes percentage
T10872 15176-15180 NN denotes cell
T10873 15181-15190 NN denotes viability
T10874 15191-15194 VB denotes was
T10875 15195-15205 VB denotes calculated
T10876 15206-15210 IN denotes with
T10877 15211-15214 DT denotes the
T10878 15215-15222 NN denotes formula
T10879 15223-15226 CD denotes 100
T10880 15227-15228 NN denotes ×
T10881 15229-15230 -LRB- denotes (
T10882 15230-15236 NN denotes number
T10883 15237-15239 IN denotes of
T10884 15240-15246 JJ denotes viable
T10885 15247-15259 NN denotes cells/number
T10886 15260-15262 IN denotes of
T10887 15263-15267 CC denotes both
T10888 15268-15274 JJ denotes viable
T10889 15275-15278 CC denotes and
T10890 15279-15283 JJ denotes dead
T10891 15284-15289 NN denotes cells
T10892 15289-15290 -RRB- denotes )
T10893 15291-15292 -LRB- denotes [
T10894 15292-15294 CD denotes 21
T10895 15294-15295 -RRB- denotes ]
T11018 15298-15309 JJ denotes Statistical
T11019 15310-15318 NN denotes analysis
T11020 15319-15323 NN denotes Data
T11021 15324-15327 VB denotes are
T11022 15328-15337 VB denotes expressed
T11023 15338-15340 IN denotes as
T11024 15341-15346 NN denotes means
T11025 15347-15348 CC denotes ±
T11026 15349-15352 NN denotes SEM
T11027 15354-15365 JJ denotes Statistical
T11028 15366-15374 NN denotes analysis
T11029 15375-15378 VB denotes was
T11030 15379-15388 VB denotes performed
T11031 15389-15393 IN denotes with
T11032 15394-15401 NN denotes Student
T11033 15401-15403 POS denotes 's
T11034 15404-15410 NN denotes t-test
T11035 15411-15414 IN denotes for
T11036 15415-15422 JJ denotes matched
T11037 15423-15428 NN denotes pairs
T11038 15430-15431 NN denotes P
T11039 15432-15438 NN denotes values
T11040 15439-15443 JJ denotes less
T11041 15444-15448 IN denotes than
T11042 15449-15453 CD denotes 0.05
T11043 15454-15458 VB denotes were
T11044 15459-15469 VB denotes considered
T11045 15470-15481 JJ denotes significant
T11242 15493-15498 NN denotes IL-17
T11243 15499-15509 NN denotes production
T11244 15510-15512 IN denotes in
T11245 15513-15517 NN denotes PBMC
T11246 15518-15522 IN denotes from
T11247 15523-15531 NN denotes patients
T11248 15532-15536 IN denotes with
T11249 15537-15539 NN denotes RA
T11250 15539-15540 -COMMA- denotes ,
T11251 15541-15549 NN denotes patients
T11252 15550-15554 IN denotes with
T11253 15555-15557 NN denotes OA
T11254 15558-15561 CC denotes and
T11255 15562-15568 JJ denotes normal
T11256 15569-15580 NN denotes individuals
T11257 15581-15585 NN denotes PBMC
T11258 15586-15590 VB denotes were
T11259 15591-15600 VB denotes separated
T11260 15601-15604 CC denotes and
T11261 15605-15613 VB denotes cultured
T11262 15614-15618 IN denotes with
T11263 15619-15622 NN denotes PHA
T11264 15623-15624 -LRB- denotes (
T11265 15624-15625 CD denotes 5
T11266 15626-15631 NN denotes μg/ml
T11267 15631-15632 -RRB- denotes )
T11268 15633-15637 IN denotes from
T11269 15638-15646 NN denotes patients
T11270 15647-15651 IN denotes with
T11271 15652-15654 NN denotes RA
T11272 15654-15655 -COMMA- denotes ,
T11273 15656-15664 NN denotes patients
T11274 15665-15669 IN denotes with
T11275 15670-15672 NN denotes OA
T11276 15672-15673 -COMMA- denotes ,
T11277 15674-15677 CC denotes and
T11278 15678-15689 JJ denotes age-matched
T11279 15690-15696 JJ denotes normal
T11280 15697-15705 NN denotes controls
T11281 15705-15706 -COLON- denotes ;
T11282 15707-15712 NN denotes IL-17
T11283 15713-15719 NN denotes levels
T11284 15720-15724 VB denotes were
T11285 15725-15729 RB denotes then
T11286 15730-15740 VB denotes determined
T11287 15741-15743 IN denotes in
T11288 15744-15747 DT denotes the
T11289 15748-15755 NN denotes culture
T11290 15756-15768 NN denotes supernatants
T11291 15769-15770 -LRB- denotes (
T11292 15770-15774 NN denotes Fig.
T11293 15775-15776 CD denotes 1
T11294 15776-15777 -RRB- denotes )
T11295 15779-15787 IN denotes Although
T11296 15788-15791 DT denotes the
T11297 15792-15799 NN denotes amounts
T11298 15800-15802 IN denotes of
T11299 15803-15808 JJ denotes basal
T11300 15809-15814 NN denotes IL-17
T11301 15815-15824 NN denotes secretion
T11302 15825-15829 VB denotes were
T11303 15830-15833 RB denotes not
T11304 15834-15843 JJ denotes different
T11305 15844-15851 IN denotes between
T11306 15852-15854 NN denotes RA
T11307 15854-15855 -COMMA- denotes ,
T11308 15856-15858 NN denotes OA
T11309 15859-15862 CC denotes and
T11310 15863-15869 JJ denotes normal
T11311 15870-15878 NN denotes controls
T11312 15879-15880 -LRB- denotes (
T11313 15880-15882 CD denotes 62
T11314 15883-15884 SYM denotes ±
T11315 15885-15887 CD denotes 31
T11316 15887-15888 -COMMA- denotes ,
T11317 15889-15891 CD denotes 43
T11318 15892-15893 SYM denotes ±
T11319 15894-15896 CD denotes 19
T11320 15897-15900 CC denotes and
T11321 15901-15903 CD denotes 43
T11322 15904-15905 SYM denotes ±
T11323 15906-15908 CD denotes 10
T11324 15909-15914 NN denotes pg/ml
T11325 15914-15915 -COMMA- denotes ,
T11326 15916-15928 RB denotes respectively
T11327 15928-15929 -RRB- denotes )
T11328 15929-15930 -COMMA- denotes ,
T11329 15931-15934 DT denotes the
T11330 15935-15940 NN denotes IL-17
T11331 15941-15951 NN denotes production
T11332 15952-15962 VB denotes stimulated
T11333 15963-15965 IN denotes by
T11334 15966-15969 NN denotes PHA
T11335 15970-15973 VB denotes was
T11336 15974-15987 RB denotes significantly
T11337 15988-15994 JJ denotes higher
T11338 15995-15997 IN denotes in
T11339 15998-16000 NN denotes RA
T11340 16001-16005 NN denotes PBMC
T11341 16006-16010 IN denotes than
T11342 16011-16013 IN denotes in
T11343 16014-16019 DT denotes those
T11344 16020-16024 IN denotes from
T11345 16025-16027 NN denotes OA
T11346 16028-16031 CC denotes and
T11347 16032-16040 NN denotes controls
T11348 16041-16042 -LRB- denotes (
T11349 16042-16045 CD denotes 768
T11350 16046-16047 SYM denotes ±
T11351 16048-16051 CD denotes 295
T11352 16052-16058 IN denotes versus
T11353 16059-16062 CD denotes 463
T11354 16063-16064 SYM denotes ±
T11355 16065-16068 CD denotes 211
T11356 16069-16074 NN denotes pg/ml
T11357 16075-16076 -LRB- denotes [
T11358 16076-16077 NN denotes P
T11359 16078-16079 SYM denotes <
T11360 16080-16084 CD denotes 0.05
T11361 16084-16085 -RRB- denotes ]
T11362 16086-16089 CC denotes and
T11363 16090-16093 CD denotes 241
T11364 16094-16095 SYM denotes ±
T11365 16096-16098 CD denotes 29
T11366 16099-16104 NN denotes pg/ml
T11367 16105-16106 -LRB- denotes [
T11368 16106-16107 NN denotes P
T11369 16108-16109 SYM denotes <
T11370 16110-16115 CD denotes 0.001
T11371 16115-16116 -RRB- denotes ]
T11372 16116-16117 -RRB- denotes )
T11795 16120-16129 VB denotes Increased
T11796 16130-16135 NN denotes IL-17
T11797 16136-16146 NN denotes production
T11798 16147-16149 IN denotes in
T11799 16150-16154 NN denotes PBMC
T11800 16155-16157 IN denotes of
T11801 16158-16166 NN denotes patients
T11802 16167-16171 IN denotes with
T11803 16172-16174 NN denotes RA
T11804 16175-16177 IN denotes by
T11805 16178-16186 JJ denotes anti-CD3
T11806 16187-16193 CC denotes and/or
T11807 16194-16203 NN denotes anti-CD28
T11808 16203-16204 -COMMA- denotes ,
T11809 16205-16208 CC denotes and
T11810 16209-16212 NN denotes PHA
T11811 16213-16220 IN denotes Because
T11812 16221-16226 NN denotes IL-17
T11813 16227-16230 VB denotes was
T11814 16231-16238 RB denotes already
T11815 16239-16244 VB denotes known
T11816 16245-16249 IN denotes from
T11817 16250-16257 JJ denotes earlier
T11818 16258-16265 NN denotes reports
T11819 16266-16268 TO denotes to
T11820 16269-16271 VB denotes be
T11821 16272-16280 VB denotes produced
T11822 16281-16287 RB denotes mainly
T11823 16288-16290 IN denotes by
T11824 16291-16300 VB denotes activated
T11825 16301-16302 NN denotes T
T11826 16303-16308 NN denotes cells
T11827 16308-16309 -COMMA- denotes ,
T11828 16310-16312 PRP denotes we
T11829 16313-16325 VB denotes investigated
T11830 16326-16329 DT denotes the
T11831 16330-16336 NN denotes effect
T11832 16337-16339 IN denotes of
T11833 16340-16349 JJ denotes different
T11834 16350-16364 NN denotes concentrations
T11835 16365-16367 IN denotes of
T11836 16368-16376 NN denotes anti-CD3
T11837 16377-16378 -LRB- denotes (
T11838 16378-16379 CD denotes 1
T11839 16379-16380 -COMMA- denotes ,
T11840 16381-16382 CD denotes 5
T11841 16383-16386 CC denotes and
T11842 16387-16389 CD denotes 10
T11843 16390-16395 NN denotes μg/ml
T11844 16395-16396 -RRB- denotes )
T11845 16397-16399 IN denotes as
T11846 16400-16401 DT denotes a
T11847 16402-16403 NN denotes T
T11848 16404-16408 NN denotes cell
T11849 16409-16419 NN denotes activation
T11850 16419-16420 -COMMA- denotes ,
T11851 16421-16426 WDT denotes which
T11852 16427-16433 VB denotes showed
T11853 16434-16435 DT denotes a
T11854 16436-16450 JJ denotes dose-dependent
T11855 16451-16459 NN denotes increase
T11856 16460-16462 IN denotes in
T11857 16463-16468 NN denotes IL-17
T11858 16469-16475 NN denotes levels
T11859 16476-16477 -LRB- denotes (
T11860 16477-16481 NN denotes data
T11861 16482-16485 RB denotes not
T11862 16486-16491 VB denotes shown
T11863 16491-16492 -RRB- denotes )
T11864 16494-16496 IN denotes On
T11865 16497-16500 DT denotes the
T11866 16501-16506 NN denotes basis
T11867 16507-16509 IN denotes of
T11868 16510-16514 DT denotes this
T11869 16514-16515 -COMMA- denotes ,
T11870 16516-16518 PRP denotes we
T11871 16519-16524 VB denotes chose
T11872 16525-16527 CD denotes 10
T11873 16528-16533 NN denotes μg/ml
T11874 16534-16536 IN denotes as
T11875 16537-16538 DT denotes a
T11876 16539-16550 NN denotes stimulation
T11877 16551-16564 NN denotes concentration
T11878 16565-16568 IN denotes for
T11879 16569-16577 NN denotes anti-CD3
T11880 16579-16581 IN denotes As
T11881 16582-16587 VB denotes shown
T11882 16588-16590 IN denotes in
T11883 16591-16596 JJ denotes Table
T11884 16597-16598 CD denotes 1
T11885 16598-16599 -COMMA- denotes ,
T11886 16600-16608 JJ denotes anti-CD3
T11887 16609-16622 RB denotes significantly
T11888 16623-16634 VB denotes upregulated
T11889 16635-16640 NN denotes IL-17
T11890 16641-16651 NN denotes production
T11891 16652-16654 IN denotes up
T11892 16655-16657 TO denotes to
T11893 16658-16666 RB denotes 3.7-fold
T11894 16666-16667 -COMMA- denotes ,
T11895 16668-16671 CC denotes and
T11896 16672-16675 DT denotes the
T11897 16676-16687 NN denotes combination
T11898 16688-16690 IN denotes of
T11899 16691-16700 NN denotes anti-CD28
T11900 16701-16704 CC denotes and
T11901 16705-16713 NN denotes anti-CD3
T11902 16714-16722 VB denotes produced
T11903 16723-16727 JJ denotes more
T11904 16728-16733 NN denotes IL-17
T11905 16734-16735 -LRB- denotes (
T11906 16735-16748 RB denotes approximately
T11907 16749-16761 RB denotes 1.3-1.5-fold
T11908 16761-16762 -RRB- denotes )
T11909 16763-16767 IN denotes than
T11910 16768-16776 NN denotes anti-CD3
T11911 16777-16782 RB denotes alone
T11912 16784-16795 RB denotes Furthermore
T11913 16795-16796 -COMMA- denotes ,
T11914 16797-16801 WRB denotes when
T11915 16802-16811 VB denotes incubated
T11916 16812-16816 IN denotes with
T11917 16817-16818 NN denotes T
T11918 16819-16823 NN denotes cell
T11919 16824-16832 NN denotes mitogens
T11920 16833-16837 JJ denotes such
T11921 16838-16840 IN denotes as
T11922 16841-16844 NN denotes PHA
T11923 16844-16845 -COMMA- denotes ,
T11924 16846-16855 VB denotes increased
T11925 16856-16861 NN denotes IL-17
T11926 16862-16872 NN denotes production
T11927 16873-16876 VB denotes was
T11928 16877-16881 RB denotes more
T11929 16882-16892 JJ denotes pronounced
T11930 16893-16897 IN denotes than
T11931 16898-16902 IN denotes with
T11932 16903-16911 JJ denotes anti-CD3
T11933 16912-16915 CC denotes and
T11934 16916-16925 JJ denotes anti-CD28
T11935 16926-16927 -LRB- denotes (
T11936 16927-16930 CD denotes 588
T11937 16931-16932 SYM denotes ±
T11938 16933-16935 CD denotes 85
T11939 16936-16942 IN denotes versus
T11940 16943-16946 CD denotes 211
T11941 16947-16948 SYM denotes ±
T11942 16949-16950 CD denotes 1
T11943 16951-16956 NN denotes pg/ml
T11944 16956-16957 -COLON- denotes ;
T11945 16958-16959 NN denotes P
T11946 16960-16961 SYM denotes <
T11947 16962-16966 CD denotes 0.05
T11948 16966-16967 -RRB- denotes )
T12640 16970-16980 NN denotes Regulation
T12641 16981-16983 IN denotes of
T12642 16984-16989 NN denotes IL-17
T12643 16990-17000 NN denotes production
T12644 17001-17003 IN denotes in
T12645 17004-17006 NN denotes RA
T12646 17007-17011 NN denotes PBMC
T12647 17012-17014 IN denotes by
T12648 17015-17027 JJ denotes inflammatory
T12649 17028-17037 NN denotes cytokines
T12650 17038-17041 CC denotes and
T12651 17042-17052 NN denotes chemokines
T12652 17053-17060 IN denotes Because
T12653 17061-17063 NN denotes RA
T12654 17064-17068 NN denotes PBMC
T12655 17069-17076 VB denotes include
T12656 17077-17084 JJ denotes several
T12657 17085-17089 NN denotes cell
T12658 17090-17095 NN denotes types
T12659 17096-17098 IN denotes in
T12660 17099-17107 NN denotes addition
T12661 17108-17110 TO denotes to
T12662 17111-17112 NN denotes T
T12663 17113-17118 NN denotes cells
T12664 17118-17119 -COMMA- denotes ,
T12665 17120-17124 DT denotes some
T12666 17125-17137 JJ denotes inflammatory
T12667 17138-17147 NN denotes cytokines
T12668 17148-17156 VB denotes released
T12669 17157-17161 IN denotes from
T12670 17162-17173 NN denotes macrophages
T12671 17174-17177 CC denotes and
T12672 17178-17183 JJ denotes other
T12673 17184-17195 NN denotes lymphocytes
T12674 17196-17201 MD denotes might
T12675 17202-17206 VB denotes have
T12676 17207-17215 VB denotes affected
T12677 17216-17219 DT denotes the
T12678 17220-17230 NN denotes production
T12679 17231-17233 IN denotes of
T12680 17234-17239 NN denotes IL-17
T12681 17240-17244 IN denotes from
T12682 17245-17246 NN denotes T
T12683 17247-17252 NN denotes cells
T12684 17254-17256 TO denotes To
T12685 17257-17265 VB denotes evaluate
T12686 17266-17269 DT denotes the
T12687 17270-17277 NN denotes effects
T12688 17278-17280 IN denotes of
T12689 17281-17293 JJ denotes inflammatory
T12690 17294-17303 NN denotes cytokines
T12691 17304-17312 VB denotes released
T12692 17313-17315 IN denotes by
T12693 17316-17325 VB denotes activated
T12694 17326-17330 NN denotes PBMC
T12695 17330-17331 -COMMA- denotes ,
T12696 17332-17334 PRP denotes we
T12697 17335-17341 VB denotes tested
T12698 17342-17345 DT denotes the
T12699 17346-17353 NN denotes effects
T12700 17354-17356 IN denotes of
T12701 17357-17364 JJ denotes several
T12702 17365-17374 NN denotes cytokines
T12703 17375-17378 CC denotes and
T12704 17379-17389 NN denotes chemokines
T12705 17390-17392 IN denotes on
T12706 17393-17398 NN denotes IL-17
T12707 17399-17409 NN denotes production
T12708 17411-17413 PRP denotes We
T12709 17414-17422 VB denotes detected
T12710 17423-17425 DT denotes an
T12711 17426-17434 NN denotes increase
T12712 17435-17437 IN denotes in
T12713 17438-17443 NN denotes IL-17
T12714 17444-17449 NN denotes level
T12715 17450-17455 IN denotes after
T12716 17456-17467 NN denotes stimulation
T12717 17468-17472 IN denotes with
T12718 17473-17478 NN denotes IL-15
T12719 17479-17480 -LRB- denotes (
T12720 17480-17482 CD denotes 10
T12721 17483-17488 NN denotes ng/ml
T12722 17488-17489 -RRB- denotes )
T12723 17489-17490 -COMMA- denotes ,
T12724 17491-17498 IN denotes whereas
T12725 17499-17503 IN denotes with
T12726 17504-17509 NN denotes IL-1β
T12727 17510-17511 -LRB- denotes (
T12728 17511-17513 CD denotes 10
T12729 17514-17519 NN denotes ng/ml
T12730 17519-17520 -RRB- denotes )
T12731 17520-17521 -COMMA- denotes ,
T12732 17522-17527 NN denotes TNF-α
T12733 17528-17529 -LRB- denotes (
T12734 17529-17531 CD denotes 10
T12735 17532-17537 NN denotes ng/ml
T12736 17537-17538 -RRB- denotes )
T12737 17538-17539 -COMMA- denotes ,
T12738 17540-17545 NN denotes IL-18
T12739 17546-17547 -LRB- denotes (
T12740 17547-17549 CD denotes 10
T12741 17550-17555 NN denotes ng/ml
T12742 17555-17556 -RRB- denotes )
T12743 17557-17559 CC denotes or
T12744 17560-17565 NN denotes TGF-β
T12745 17566-17567 -LRB- denotes (
T12746 17567-17569 CD denotes 10
T12747 17570-17575 NN denotes ng/ml
T12748 17575-17576 -RRB- denotes )
T12749 17577-17580 DT denotes the
T12750 17581-17587 NN denotes levels
T12751 17588-17590 IN denotes in
T12752 17591-17596 NN denotes IL-17
T12753 17597-17601 VB denotes were
T12754 17602-17611 JJ denotes unchanged
T12755 17612-17613 -LRB- denotes (
T12756 17613-17617 NN denotes Fig.
T12757 17618-17620 NN denotes 2a
T12758 17620-17621 -RRB- denotes )
T12759 17623-17627 WRB denotes When
T12760 17628-17635 VB denotes treated
T12761 17636-17640 IN denotes with
T12762 17641-17646 NN denotes MCP-1
T12763 17647-17648 -LRB- denotes (
T12764 17648-17650 CD denotes 10
T12765 17651-17656 NN denotes ng/ml
T12766 17656-17657 -RRB- denotes )
T12767 17658-17660 CC denotes or
T12768 17661-17665 NN denotes IL-6
T12769 17666-17667 -LRB- denotes (
T12770 17667-17669 CD denotes 10
T12771 17670-17675 NN denotes ng/ml
T12772 17675-17676 -RRB- denotes )
T12773 17676-17677 -COMMA- denotes ,
T12774 17678-17689 JJ denotes significant
T12775 17690-17703 NN denotes upregulations
T12776 17704-17706 IN denotes of
T12777 17707-17712 NN denotes IL-17
T12778 17713-17721 NN denotes proteins
T12779 17722-17726 VB denotes were
T12780 17727-17735 VB denotes observed
T12781 17736-17737 -LRB- denotes (
T12782 17737-17739 CD denotes 62
T12783 17740-17741 CC denotes ±
T12784 17742-17744 CD denotes 42
T12785 17745-17748 CC denotes and
T12786 17749-17751 CD denotes 50
T12787 17752-17753 SYM denotes ±
T12788 17754-17756 CD denotes 10
T12789 17757-17763 IN denotes versus
T12790 17764-17766 CD denotes 31
T12791 17767-17768 SYM denotes ±
T12792 17769-17771 CD denotes 11
T12793 17772-17777 NN denotes pg/ml
T12794 17777-17778 -COMMA- denotes ,
T12795 17779-17791 RB denotes respectively
T12796 17791-17792 -COLON- denotes ;
T12797 17793-17794 NN denotes P
T12798 17795-17796 SYM denotes <
T12799 17797-17801 CD denotes 0.05
T12800 17801-17802 -RRB- denotes )
T12801 17802-17803 -COMMA- denotes ,
T12802 17804-17811 IN denotes whereas
T12803 17812-17816 NN denotes none
T12804 17817-17820 VB denotes was
T12805 17821-17829 VB denotes observed
T12806 17830-17834 IN denotes with
T12807 17835-17839 NN denotes IL-8
T12808 17840-17841 -LRB- denotes (
T12809 17841-17843 CD denotes 10
T12810 17844-17849 NN denotes ng/ml
T12811 17849-17850 -RRB- denotes )
T12812 17850-17851 -COMMA- denotes ,
T12813 17852-17858 NN denotes MIP-1α
T12814 17859-17860 -LRB- denotes (
T12815 17860-17862 CD denotes 10
T12816 17863-17868 NN denotes ng/ml
T12817 17868-17869 -RRB- denotes )
T12818 17870-17872 CC denotes or
T12819 17873-17879 NN denotes MIP-1β
T12820 17880-17881 -LRB- denotes (
T12821 17881-17883 CD denotes 10
T12822 17884-17889 NN denotes ng/ml
T12823 17889-17890 -RRB- denotes )
T12824 17891-17892 -LRB- denotes (
T12825 17892-17896 NN denotes Fig.
T12826 17897-17899 NN denotes 2b
T12827 17899-17900 -RRB- denotes )
T13598 17903-17913 NN denotes Inhibition
T13599 17914-17916 IN denotes of
T13600 17917-17922 NN denotes IL-17
T13601 17923-17933 NN denotes production
T13602 17934-17936 IN denotes by
T13603 17937-17943 NN denotes signal
T13604 17944-17956 NN denotes transduction
T13605 17957-17967 NN denotes inhibitors
T13606 17968-17971 CC denotes and
T13607 17972-17986 JJ denotes anti-rheumatic
T13608 17987-17992 NN denotes drugs
T13609 17993-17999 VB denotes Having
T13610 18000-18008 VB denotes observed
T13611 18009-18012 DT denotes the
T13612 18013-18022 VB denotes increased
T13613 18023-18028 NN denotes IL-17
T13614 18029-18039 NN denotes production
T13615 18040-18042 IN denotes in
T13616 18043-18045 NN denotes RA
T13617 18046-18050 NN denotes PBMC
T13618 18050-18051 -COMMA- denotes ,
T13619 18052-18054 PRP denotes it
T13620 18055-18058 VB denotes was
T13621 18059-18068 JJ denotes important
T13622 18069-18071 TO denotes to
T13623 18072-18076 VB denotes know
T13624 18077-18082 WDT denotes which
T13625 18083-18089 NN denotes signal
T13626 18090-18102 NN denotes transduction
T13627 18103-18111 NN denotes pathways
T13628 18112-18116 VB denotes were
T13629 18117-18125 VB denotes involved
T13630 18127-18129 IN denotes As
T13631 18130-18141 VB denotes illustrated
T13632 18142-18144 IN denotes in
T13633 18145-18149 NNP denotes Fig.
T13634 18150-18151 CD denotes 3
T13635 18151-18152 -COMMA- denotes ,
T13636 18153-18155 DT denotes an
T13637 18156-18167 JJ denotes significant
T13638 18168-18176 NN denotes decrease
T13639 18177-18179 IN denotes in
T13640 18180-18196 JJ denotes anti-CD3-induced
T13641 18197-18202 NN denotes IL-17
T13642 18203-18213 NN denotes production
T13643 18214-18217 VB denotes was
T13644 18218-18226 VB denotes observed
T13645 18227-18231 WRB denotes when
T13646 18232-18244 VB denotes co-incubated
T13647 18245-18249 IN denotes with
T13648 18250-18255 NN denotes NF-κB
T13649 18256-18265 NN denotes inhibitor
T13650 18265-18266 -COMMA- denotes ,
T13651 18267-18271 NN denotes PDTC
T13652 18272-18275 CC denotes and
T13653 18276-18289 NN denotes dexamethasone
T13654 18290-18292 IN denotes in
T13655 18293-18303 NN denotes comparison
T13656 18304-18308 IN denotes with
T13657 18309-18317 NN denotes anti-CD3
T13658 18318-18323 RB denotes alone
T13659 18324-18325 -LRB- denotes (
T13660 18325-18327 CD denotes 38
T13661 18328-18329 CC denotes ±
T13662 18330-18331 CD denotes 5
T13663 18332-18335 CC denotes and
T13664 18336-18338 CD denotes 54
T13665 18339-18340 CC denotes ±
T13666 18341-18343 CD denotes 11
T13667 18344-18350 IN denotes versus
T13668 18351-18353 CD denotes 98
T13669 18354-18355 SYM denotes ±
T13670 18356-18358 CD denotes 19
T13671 18359-18364 NN denotes pg/ml
T13672 18364-18365 -COMMA- denotes ,
T13673 18366-18378 RB denotes respectively
T13674 18378-18379 -COLON- denotes ;
T13675 18380-18381 NN denotes P
T13676 18382-18383 SYM denotes <
T13677 18384-18388 CD denotes 0.05
T13678 18388-18389 -RRB- denotes )
T13679 18391-18399 NN denotes LY294002
T13680 18400-18403 CC denotes and
T13681 18404-18414 NN denotes wortmannin
T13682 18414-18415 -COMMA- denotes ,
T13683 18416-18418 IN denotes as
T13684 18419-18421 DT denotes an
T13685 18422-18431 NN denotes inhibitor
T13686 18432-18434 IN denotes of
T13687 18435-18439 NN denotes PI3K
T13688 18439-18440 -COMMA- denotes ,
T13689 18441-18445 RB denotes also
T13690 18446-18454 RB denotes markedly
T13691 18455-18464 VB denotes inhibited
T13692 18465-18468 DT denotes the
T13693 18469-18485 JJ denotes anti-CD3-induced
T13694 18486-18491 NN denotes IL-17
T13695 18492-18502 NN denotes production
T13696 18503-18505 IN denotes in
T13697 18506-18508 NN denotes RA
T13698 18509-18513 NN denotes PBMC
T13699 18514-18515 -LRB- denotes (
T13700 18515-18517 CD denotes 98
T13701 18518-18519 SYM denotes ±
T13702 18520-18522 CD denotes 19
T13703 18523-18529 IN denotes versus
T13704 18530-18532 CD denotes 38
T13705 18533-18534 SYM denotes ±
T13706 18535-18537 CD denotes 10
T13707 18538-18543 NN denotes pg/ml
T13708 18544-18545 -LRB- denotes [
T13709 18545-18546 NN denotes P
T13710 18547-18548 SYM denotes <
T13711 18549-18554 CD denotes 0.005
T13712 18554-18555 -RRB- denotes ]
T13713 18556-18559 CC denotes and
T13714 18560-18562 CD denotes 48
T13715 18563-18564 CC denotes ±
T13716 18565-18566 CD denotes 4
T13717 18567-18572 NN denotes pg/ml
T13718 18573-18574 -LRB- denotes [
T13719 18574-18575 NN denotes P
T13720 18576-18577 SYM denotes <
T13721 18578-18582 CD denotes 0.05
T13722 18582-18583 -RRB- denotes ]
T13723 18583-18584 -COMMA- denotes ,
T13724 18585-18597 RB denotes respectively
T13725 18597-18598 -RRB- denotes )
T13726 18600-18603 DT denotes The
T13727 18604-18615 NN denotes calcineurin
T13728 18616-18626 NN denotes inhibitors
T13729 18627-18638 NN denotes cyclosporin
T13730 18639-18640 NN denotes A
T13731 18641-18644 CC denotes and
T13732 18645-18650 NN denotes FK506
T13733 18651-18655 RB denotes also
T13734 18656-18669 VB denotes downregulated
T13735 18670-18673 DT denotes the
T13736 18674-18679 NN denotes IL-17
T13737 18680-18689 NN denotes secretion
T13738 18690-18692 RB denotes as
T13739 18693-18697 RB denotes well
T13740 18698-18700 IN denotes as
T13741 18701-18704 DT denotes the
T13742 18705-18722 JJ denotes mitogen-activated
T13743 18723-18730 NN denotes protein
T13744 18731-18737 NN denotes kinase
T13745 18738-18739 -LRB- denotes (
T13746 18739-18743 NN denotes MAPK
T13747 18743-18744 -RRB- denotes )
T13748 18745-18748 NN denotes p38
T13749 18749-18758 NN denotes inhibitor
T13750 18759-18767 NN denotes SB203580
T13751 18768-18771 VB denotes did
T13752 18771-18772 -COMMA- denotes ,
T13753 18773-18780 IN denotes whereas
T13754 18781-18790 NN denotes rapamycin
T13755 18791-18794 CC denotes and
T13756 18795-18802 NN denotes PD98059
T13757 18803-18806 VB denotes had
T13758 18807-18809 DT denotes no
T13759 18810-18816 NN denotes effect
T13760 18817-18819 IN denotes on
T13761 18820-18825 NN denotes IL-17
T13762 18826-18832 NN denotes levels
T13763 18833-18834 -LRB- denotes (
T13764 18834-18838 NN denotes Fig.
T13765 18839-18840 CD denotes 3
T13766 18840-18841 -RRB- denotes )
T13767 18843-18845 TO denotes To
T13768 18846-18854 VB denotes evaluate
T13769 18855-18858 DT denotes the
T13770 18859-18870 NN denotes possibility
T13771 18871-18873 IN denotes of
T13772 18874-18886 JJ denotes non-specific
T13773 18887-18897 NN denotes inhibition
T13774 18898-18900 IN denotes by
T13775 18901-18904 DT denotes the
T13776 18905-18909 NN denotes drug
T13777 18910-18912 IN denotes at
T13778 18913-18917 JJ denotes high
T13779 18918-18932 NN denotes concentrations
T13780 18932-18933 -COMMA- denotes ,
T13781 18934-18936 PRP denotes we
T13782 18937-18945 VB denotes observed
T13783 18946-18949 DT denotes the
T13784 18950-18954 NN denotes dose
T13785 18955-18963 NN denotes response
T13786 18964-18966 IN denotes of
T13787 18967-18971 NN denotes PDTC
T13788 18972-18975 CC denotes and
T13789 18976-18984 NN denotes LY294002
T13790 18985-18988 IN denotes for
T13791 18989-18992 DT denotes the
T13792 18993-19003 NN denotes inhibition
T13793 19004-19006 IN denotes of
T13794 19007-19012 NN denotes IL-17
T13795 19013-19023 NN denotes production
T13796 19024-19026 IN denotes in
T13797 19027-19031 NN denotes PBMC
T13798 19033-19038 EX denotes There
T13799 19039-19043 VB denotes were
T13800 19044-19058 JJ denotes dose-dependent
T13801 19059-19070 NN denotes inhibitions
T13802 19071-19073 IN denotes of
T13803 19074-19079 NN denotes IL-17
T13804 19080-19090 NN denotes production
T13805 19091-19095 IN denotes with
T13806 19096-19104 JJ denotes chemical
T13807 19105-19115 NN denotes inhibitors
T13808 19116-19117 -LRB- denotes (
T13809 19117-19121 NN denotes Fig.
T13810 19122-19124 NN denotes 4a
T13811 19124-19125 -RRB- denotes )
T13812 19127-19130 DT denotes The
T13813 19131-19136 JJ denotes other
T13814 19137-19147 NN denotes inhibitors
T13815 19148-19150 IN denotes in
T13816 19151-19159 NN denotes addition
T13817 19160-19162 TO denotes to
T13818 19163-19167 NN denotes PDTC
T13819 19168-19171 CC denotes and
T13820 19172-19180 NN denotes LY294002
T13821 19181-19187 VB denotes showed
T13822 19188-19191 DT denotes the
T13823 19192-19196 JJ denotes same
T13824 19197-19204 NN denotes pattern
T13825 19205-19207 IN denotes of
T13826 19208-19218 NN denotes inhibition
T13827 19220-19229 JJ denotes Cytotoxic
T13828 19230-19237 NN denotes effects
T13829 19238-19240 IN denotes on
T13830 19241-19245 NN denotes PBMC
T13831 19246-19248 IN denotes by
T13832 19249-19252 DT denotes the
T13833 19253-19261 JJ denotes chemical
T13834 19262-19272 NN denotes inhibitors
T13835 19273-19275 IN denotes at
T13836 19276-19288 JJ denotes experimental
T13837 19289-19303 NN denotes concentrations
T13838 19304-19308 VB denotes were
T13839 19309-19312 RB denotes not
T13840 19313-19321 VB denotes observed
T13841 19322-19323 -LRB- denotes (
T13842 19323-19327 NNP denotes Fig.
T13843 19328-19330 NN denotes 4b
T13844 19330-19331 -RRB- denotes )
T14506 19334-19339 NN denotes IL-17
T14507 19340-19344 NN denotes mRNA
T14508 19345-19355 NN denotes expression
T14509 19356-19358 IN denotes in
T14510 19359-19361 NN denotes RA
T14511 19362-19366 NN denotes PBMC
T14512 19367-19369 TO denotes To
T14513 19370-19373 VB denotes see
T14514 19374-19381 IN denotes whether
T14515 19382-19390 VB denotes enhanced
T14516 19391-19396 NN denotes IL-17
T14517 19397-19407 NN denotes production
T14518 19408-19413 MD denotes could
T14519 19414-19416 VB denotes be
T14520 19417-19426 VB denotes regulated
T14521 19427-19429 IN denotes at
T14522 19430-19431 DT denotes a
T14523 19432-19447 JJ denotes transcriptional
T14524 19448-19453 NN denotes level
T14525 19453-19454 -COMMA- denotes ,
T14526 19455-19472 JJ denotes semi-quantatitive
T14527 19473-19480 JJ denotes reverse
T14528 19481-19505 NN denotes transcription–polymerase
T14529 19506-19511 NN denotes chain
T14530 19512-19520 NN denotes reaction
T14531 19521-19524 VB denotes was
T14532 19525-19534 VB denotes performed
T14533 19536-19538 PRP denotes We
T14534 19539-19547 VB denotes observed
T14535 19548-19549 DT denotes a
T14536 19550-19564 JJ denotes dose-dependent
T14537 19565-19573 NN denotes increase
T14538 19574-19576 IN denotes in
T14539 19577-19582 NN denotes IL-17
T14540 19583-19587 NN denotes mRNA
T14541 19588-19599 NN denotes transcripts
T14542 19600-19605 IN denotes after
T14543 19606-19617 NN denotes stimulation
T14544 19618-19622 IN denotes with
T14545 19623-19631 NN denotes anti-CD3
T14546 19631-19632 -COLON- denotes ;
T14547 19633-19637 DT denotes this
T14548 19638-19641 VB denotes was
T14549 19642-19651 VB denotes inhibited
T14550 19652-19654 IN denotes by
T14551 19655-19658 DT denotes the
T14552 19659-19663 NN denotes PI3K
T14553 19664-19673 NN denotes inhibitor
T14554 19674-19682 NN denotes LY294002
T14555 19683-19686 CC denotes and
T14556 19687-19689 IN denotes by
T14557 19690-19693 DT denotes the
T14558 19694-19699 NN denotes NF-κB
T14559 19700-19709 NN denotes inhibitor
T14560 19710-19714 NN denotes PDTC
T14561 19715-19716 -LRB- denotes (
T14562 19716-19720 NNP denotes Fig.
T14563 19721-19722 CD denotes 5
T14564 19722-19723 -RRB- denotes )
T14971 19726-19736 NN denotes Activation
T14972 19737-19739 IN denotes of
T14973 19740-19748 NN denotes PI3K/Akt
T14974 19749-19755 NN denotes signal
T14975 19756-19768 NN denotes transduction
T14976 19769-19776 NN denotes pathway
T14977 19777-19779 IN denotes on
T14978 19780-19785 NN denotes IL-17
T14979 19786-19796 NN denotes production
T14980 19797-19799 IN denotes by
T14981 19800-19808 JJ denotes anti-CD3
T14982 19809-19811 TO denotes To
T14983 19812-19821 VB denotes determine
T14984 19822-19832 JJ denotes downstream
T14985 19833-19841 NN denotes effector
T14986 19842-19851 NN denotes molecules
T14987 19852-19854 IN denotes of
T14988 19855-19858 DT denotes the
T14989 19859-19863 NN denotes PI3K
T14990 19864-19871 NN denotes pathway
T14991 19871-19872 -COMMA- denotes ,
T14992 19873-19875 PRP denotes we
T14993 19876-19885 VB denotes evaluated
T14994 19886-19889 DT denotes the
T14995 19890-19900 NN denotes activation
T14996 19901-19903 IN denotes of
T14997 19904-19907 NN denotes Akt
T14998 19908-19910 IN denotes by
T14999 19911-19918 JJ denotes western
T15000 19919-19927 NN denotes blotting
T15001 19929-19931 IN denotes As
T15002 19932-19937 VB denotes shown
T15003 19938-19940 IN denotes in
T15004 19941-19945 NNP denotes Fig.
T15005 19946-19947 CD denotes 6
T15006 19947-19948 -COMMA- denotes ,
T15007 19949-19951 IN denotes at
T15008 19952-19954 CD denotes 10
T15009 19955-19958 NN denotes min
T15010 19959-19961 IN denotes of
T15011 19962-19972 NN denotes incubation
T15012 19973-19977 IN denotes with
T15013 19978-19986 NN denotes anti-CD3
T15014 19987-19988 -LRB- denotes (
T15015 19988-19990 CD denotes 10
T15016 19991-19996 NN denotes μg/ml
T15017 19996-19997 -RRB- denotes )
T15018 19998-20000 CC denotes or
T15019 20001-20009 NN denotes LY294002
T15020 20010-20011 -LRB- denotes (
T15021 20011-20013 CD denotes 20
T15022 20014-20016 NN denotes μM
T15023 20016-20017 -RRB- denotes )
T15024 20017-20018 -COMMA- denotes ,
T15025 20019-20021 DT denotes no
T15026 20022-20032 NN denotes difference
T15027 20033-20035 IN denotes in
T15028 20036-20039 DT denotes the
T15029 20040-20047 NN denotes amounts
T15030 20048-20050 IN denotes of
T15031 20051-20065 VB denotes phosphorylated
T15032 20066-20069 NN denotes Akt
T15033 20070-20073 VB denotes was
T15034 20074-20082 VB denotes observed
T15035 20084-20091 RB denotes However
T15036 20091-20092 -COMMA- denotes ,
T15037 20093-20098 IN denotes after
T15038 20099-20101 CD denotes 30
T15039 20102-20105 NN denotes min
T15040 20106-20108 IN denotes of
T15041 20109-20119 NN denotes incubation
T15042 20119-20120 -COMMA- denotes ,
T15043 20121-20135 VB denotes phosphorylated
T15044 20136-20139 NN denotes Akt
T15045 20140-20149 VB denotes increased
T15046 20150-20151 -LRB- denotes (
T15047 20151-20155 NN denotes lane
T15048 20156-20157 CD denotes 2
T15049 20157-20158 -RRB- denotes )
T15050 20158-20159 -COMMA- denotes ,
T15051 20160-20163 CC denotes and
T15052 20164-20167 DT denotes the
T15053 20168-20174 NN denotes effect
T15054 20175-20177 IN denotes of
T15055 20178-20188 NN denotes inhibition
T15056 20189-20191 IN denotes by
T15057 20192-20200 NN denotes LY294002
T15058 20201-20202 -LRB- denotes (
T15059 20202-20206 NN denotes lane
T15060 20207-20208 CD denotes 3
T15061 20208-20209 -RRB- denotes )
T15062 20210-20217 VB denotes reached
T15063 20218-20219 DT denotes a
T15064 20220-20224 NN denotes peak
T15065 20225-20227 IN denotes at
T15066 20228-20230 CD denotes 60
T15067 20231-20234 NN denotes min
T15068 20234-20235 -COMMA- denotes ,
T15069 20236-20243 VB denotes lasting
T15070 20244-20246 TO denotes to
T15071 20247-20254 CD denotes 120–240
T15072 20255-20258 NN denotes min
T15073 20260-20262 IN denotes In
T15074 20263-20271 NN denotes contrast
T15075 20271-20272 -COMMA- denotes ,
T15076 20273-20291 JJ denotes non-phosphorylated
T15077 20292-20295 NN denotes Akt
T15078 20296-20299 CC denotes and
T15079 20300-20307 NN denotes β-actin
T15080 20308-20316 VB denotes remained
T15081 20317-20326 JJ denotes unchanged
T15082 20327-20337 RB denotes regardless
T15083 20338-20340 IN denotes of
T15084 20341-20351 NN denotes incubation
T15085 20352-20356 NN denotes time
T15086 20358-20361 NN denotes PHA
T15087 20361-20362 -COMMA- denotes ,
T15088 20363-20375 NN denotes concanavalin
T15089 20376-20377 NN denotes A
T15090 20378-20381 CC denotes and
T15091 20382-20387 NN denotes IL-15
T15092 20388-20392 RB denotes also
T15093 20393-20405 VB denotes demonstrated
T15094 20406-20409 DT denotes the
T15095 20410-20414 JJ denotes same
T15096 20415-20421 NN denotes effect
T15097 20422-20424 IN denotes on
T15098 20425-20439 VB denotes phosphorylated
T15099 20440-20443 NN denotes Akt
T15100 20444-20446 IN denotes as
T15101 20447-20452 VB denotes shown
T15102 20453-20457 IN denotes with
T15103 20458-20466 NN denotes anti-CD3
T15104 20466-20467 -COMMA- denotes ,
T15105 20468-20473 WDT denotes which
T15106 20474-20477 VB denotes was
T15107 20478-20480 DT denotes an
T15108 20481-20491 NN denotes inhibition
T15109 20492-20494 IN denotes by
T15110 20495-20505 NN denotes wortmannin
T15111 20506-20509 CC denotes and
T15112 20510-20514 NN denotes PDTC
T15113 20515-20517 RB denotes as
T15114 20518-20522 RB denotes well
T15115 20523-20525 IN denotes as
T15116 20526-20528 IN denotes by
T15117 20529-20537 NN denotes LY294002
T15118 20538-20539 -LRB- denotes (
T15119 20539-20543 NN denotes data
T15120 20544-20547 RB denotes not
T15121 20548-20553 VB denotes shown
T15122 20553-20554 -RRB- denotes )
T15893 20557-20567 NN denotes Activation
T15894 20568-20570 IN denotes of
T15895 20571-20574 DT denotes the
T15896 20575-20580 NN denotes NF-κB
T15897 20581-20584 CC denotes and
T15898 20585-20594 NN denotes activator
T15899 20595-20604 NN denotes protein-1
T15900 20605-20606 -LRB- denotes (
T15901 20606-20610 NN denotes AP-1
T15902 20610-20611 -RRB- denotes )
T15903 20612-20619 NN denotes pathway
T15904 20620-20622 IN denotes in
T15905 20623-20626 DT denotes the
T15906 20627-20632 NN denotes IL-17
T15907 20633-20641 NN denotes promoter
T15908 20642-20648 NN denotes region
T15909 20649-20651 TO denotes To
T15910 20652-20663 VB denotes investigate
T15911 20664-20671 RB denotes further
T15912 20672-20675 DT denotes the
T15913 20676-20689 JJ denotes intracellular
T15914 20690-20699 NN denotes signaling
T15915 20700-20707 NN denotes pathway
T15916 20708-20717 VB denotes activated
T15917 20718-20720 IN denotes by
T15918 20721-20729 JJ denotes anti-CD3
T15919 20730-20734 CC denotes plus
T15920 20735-20744 NN denotes anti-CD28
T15921 20744-20745 -COMMA- denotes ,
T15922 20746-20758 NN denotes concanavalin
T15923 20759-20760 NN denotes A
T15924 20760-20761 -COMMA- denotes ,
T15925 20762-20765 NN denotes PHA
T15926 20766-20769 CC denotes and
T15927 20770-20775 NN denotes IL-15
T15928 20775-20776 -COMMA- denotes ,
T15929 20777-20780 CC denotes and
T15930 20781-20792 JJ denotes responsible
T15931 20793-20796 IN denotes for
T15932 20797-20805 VB denotes inducing
T15933 20806-20811 NN denotes IL-17
T15934 20812-20822 NN denotes expression
T15935 20822-20823 -COMMA- denotes ,
T15936 20824-20826 PRP denotes we
T15937 20827-20836 VB denotes performed
T15938 20837-20839 DT denotes an
T15939 20840-20855 JJ denotes electrophoretic
T15940 20856-20870 NN denotes mobility-shift
T15941 20871-20876 NN denotes assay
T15942 20877-20878 -LRB- denotes (
T15943 20878-20882 NN denotes EMSA
T15944 20882-20883 -RRB- denotes )
T15945 20884-20886 IN denotes of
T15946 20887-20892 NN denotes NF-κB
T15947 20893-20904 NN denotes recognition
T15948 20905-20910 NN denotes sites
T15949 20911-20913 IN denotes in
T15950 20914-20917 DT denotes the
T15951 20918-20927 NN denotes promoters
T15952 20928-20930 IN denotes of
T15953 20931-20936 NN denotes IL-17
T15954 20938-20940 IN denotes As
T15955 20941-20946 VB denotes shown
T15956 20947-20949 IN denotes in
T15957 20950-20954 NNP denotes Fig.
T15958 20955-20957 NNP denotes 7a
T15959 20957-20958 -COMMA- denotes ,
T15960 20959-20966 JJ denotes nuclear
T15961 20967-20975 NN denotes extracts
T15962 20976-20980 IN denotes from
T15963 20981-20983 NN denotes RA
T15964 20984-20988 NN denotes PBMC
T15965 20989-20999 VB denotes stimulated
T15966 21000-21004 IN denotes with
T15967 21005-21013 JJ denotes anti-CD3
T15968 21014-21018 CC denotes plus
T15969 21019-21028 NN denotes anti-CD28
T15970 21029-21030 -LRB- denotes (
T15971 21030-21034 NN denotes lane
T15972 21035-21036 CD denotes 2
T15973 21036-21037 -RRB- denotes )
T15974 21038-21050 VB denotes demonstrated
T15975 21051-21060 VB denotes increased
T15976 21061-21068 NN denotes binding
T15977 21069-21071 IN denotes of
T15978 21072-21077 NN denotes NF-κB
T15979 21078-21080 TO denotes to
T15980 21081-21086 NN denotes IL-17
T15981 21087-21096 NN denotes promoters
T15982 21097-21099 IN denotes in
T15983 21100-21110 NN denotes comparison
T15984 21111-21115 IN denotes with
T15985 21116-21120 DT denotes that
T15986 21121-21123 IN denotes of
T15987 21124-21132 NN denotes controls
T15988 21133-21134 -LRB- denotes (
T15989 21134-21138 NN denotes lane
T15990 21139-21140 CD denotes 1
T15991 21140-21141 -RRB- denotes )
T15992 21143-21144 DT denotes A
T15993 21145-21155 NN denotes supershift
T15994 21156-21161 NN denotes assay
T15995 21162-21174 VB denotes demonstrated
T15996 21175-21182 VB denotes shifted
T15997 21183-21188 NN denotes bands
T15998 21189-21191 IN denotes in
T15999 21192-21195 NN denotes p65
T16000 21196-21199 CC denotes and
T16001 21200-21203 NN denotes p50
T16002 21204-21205 -LRB- denotes (
T16003 21205-21210 NN denotes lanes
T16004 21211-21212 CD denotes 3
T16005 21213-21216 CC denotes and
T16006 21217-21218 CD denotes 4
T16007 21218-21219 -RRB- denotes )
T16008 21220-21223 RB denotes not
T16009 21224-21226 IN denotes in
T16010 21227-21232 NN denotes c-Rel
T16011 21233-21234 -LRB- denotes (
T16012 21234-21238 NN denotes lane
T16013 21239-21240 CD denotes 5
T16014 21240-21241 -RRB- denotes )
T16015 21243-21245 IN denotes In
T16016 21246-21252 JJ denotes normal
T16017 21253-21257 NN denotes PBMC
T16018 21258-21261 DT denotes the
T16019 21262-21266 JJ denotes same
T16020 21267-21274 NN denotes pattern
T16021 21275-21278 VB denotes was
T16022 21279-21287 VB denotes observed
T16023 21287-21288 -COMMA- denotes ,
T16024 21289-21292 CC denotes but
T16025 21293-21296 DT denotes the
T16026 21297-21303 NN denotes degree
T16027 21304-21306 IN denotes of
T16028 21307-21312 NN denotes NF-κB
T16029 21313-21323 NN denotes activation
T16030 21324-21326 IN denotes by
T16031 21327-21335 NN denotes anti-CD3
T16032 21336-21340 CC denotes plus
T16033 21341-21350 NN denotes anti-CD28
T16034 21351-21354 VB denotes was
T16035 21355-21359 RB denotes less
T16036 21360-21367 JJ denotes intense
T16037 21368-21372 IN denotes than
T16038 21373-21377 DT denotes that
T16039 21378-21380 IN denotes in
T16040 21381-21383 NN denotes RA
T16041 21384-21388 NN denotes PBMC
T16042 21389-21390 -LRB- denotes (
T16043 21390-21394 NN denotes Fig.
T16044 21395-21397 NN denotes 7b
T16045 21397-21398 -RRB- denotes )
T16046 21400-21402 TO denotes To
T16047 21403-21410 VB denotes confirm
T16048 21411-21414 DT denotes the
T16049 21415-21419 NN denotes link
T16050 21420-21427 IN denotes between
T16051 21428-21432 NN denotes PI3K
T16052 21433-21441 NN denotes activity
T16053 21442-21445 CC denotes and
T16054 21446-21451 NN denotes NF-κB
T16055 21451-21452 -COMMA- denotes ,
T16056 21453-21455 PRP denotes we
T16057 21456-21465 VB denotes performed
T16058 21466-21470 NN denotes EMSA
T16059 21471-21473 TO denotes to
T16060 21474-21483 VB denotes determine
T16061 21484-21487 DT denotes the
T16062 21488-21493 NN denotes NF-κB
T16063 21494-21501 NN denotes binding
T16064 21502-21510 NN denotes activity
T16065 21511-21516 IN denotes after
T16066 21517-21526 NN denotes treatment
T16067 21527-21531 IN denotes with
T16068 21532-21536 CC denotes both
T16069 21537-21545 NN denotes LY294002
T16070 21546-21549 CC denotes and
T16071 21550-21554 NN denotes PDTC
T16072 21556-21560 DT denotes Both
T16073 21561-21567 NN denotes agents
T16074 21568-21573 VB denotes block
T16075 21574-21579 NN denotes NF-κB
T16076 21580-21591 JJ denotes DNA-binding
T16077 21592-21600 NN denotes activity
T16078 21601-21603 IN denotes in
T16079 21604-21607 DT denotes the
T16080 21608-21613 NN denotes IL-17
T16081 21614-21622 NN denotes promoter
T16082 21623-21624 -LRB- denotes (
T16083 21624-21628 NN denotes Fig.
T16084 21629-21631 NN denotes 7c
T16085 21631-21632 -RRB- denotes )
T16086 21634-21641 NN denotes Western
T16087 21642-21650 NN denotes blotting
T16088 21651-21654 IN denotes for
T16089 21655-21660 NN denotes IκB-α
T16090 21661-21667 VB denotes showed
T16091 21668-21678 NN denotes inhibition
T16092 21679-21681 IN denotes of
T16093 21682-21693 NN denotes degradation
T16094 21694-21696 IN denotes of
T16095 21697-21702 NN denotes IκB-α
T16096 21703-21705 IN denotes by
T16097 21706-21714 NN denotes LY294002
T16098 21715-21718 CC denotes and
T16099 21719-21723 NN denotes PDTC
T16100 21724-21726 IN denotes at
T16101 21727-21730 DT denotes the
T16102 21731-21735 JJ denotes same
T16103 21736-21740 NN denotes time
T16104 21741-21742 -LRB- denotes (
T16105 21742-21746 NN denotes Fig.
T16106 21747-21749 NN denotes 7c
T16107 21749-21750 -RRB- denotes )
T16108 21752-21754 IN denotes In
T16109 21755-21763 NN denotes contrast
T16110 21763-21764 -COMMA- denotes ,
T16111 21765-21768 DT denotes the
T16112 21769-21773 NN denotes AP-1
T16113 21774-21781 NN denotes pathway
T16114 21782-21785 VB denotes was
T16115 21786-21789 RB denotes not
T16116 21790-21799 VB denotes activated
T16117 21800-21802 IN denotes by
T16118 21803-21814 NN denotes stimulation
T16119 21815-21819 IN denotes with
T16120 21820-21828 JJ denotes anti-CD3
T16121 21829-21833 CC denotes plus
T16122 21834-21843 JJ denotes anti-CD28
T16123 21844-21845 -LRB- denotes (
T16124 21845-21849 NN denotes data
T16125 21850-21853 RB denotes not
T16126 21854-21859 VB denotes shown
T16127 21859-21860 -RRB- denotes )
T16128 21860-21861 -COMMA- denotes ,
T16129 21862-21875 VB denotes demonstrating
T16130 21876-21880 IN denotes that
T16131 21881-21886 NN denotes NF-κB
T16132 21887-21889 VB denotes is
T16133 21890-21893 DT denotes the
T16134 21894-21898 JJ denotes main
T16135 21899-21912 JJ denotes intracellular
T16136 21913-21922 NN denotes signaling
T16137 21923-21930 NN denotes pathway
T16138 21931-21933 IN denotes in
T16139 21934-21939 NN denotes IL-17
T16140 21940-21950 NN denotes production
T16141 21951-21953 IN denotes by
T16142 21954-21963 VB denotes activated
T16143 21964-21968 NN denotes PBMC
T16144 21969-21973 IN denotes from
T16145 21974-21982 NN denotes patients
T16146 21983-21987 IN denotes with
T16147 21988-21990 NN denotes RA
T18418 22004-22009 NN denotes IL-17
T18419 22010-22013 VB denotes was
T18420 22014-22019 RB denotes first
T18421 22020-22029 VB denotes described
T18422 22030-22032 IN denotes as
T18423 22033-22034 DT denotes a
T18424 22035-22036 NN denotes T
T18425 22037-22041 NN denotes cell
T18426 22042-22049 NN denotes product
T18427 22050-22054 IN denotes with
T18428 22055-22070 JJ denotes proinflammatory
T18429 22071-22081 NN denotes properties
T18430 22082-22083 -LRB- denotes [
T18431 22083-22087 CD denotes 5,22
T18432 22087-22088 -RRB- denotes ]
T18433 22090-22092 NN denotes RA
T18434 22093-22095 VB denotes is
T18435 22096-22109 VB denotes characterized
T18436 22110-22112 IN denotes by
T18437 22113-22124 NN denotes hyperplasia
T18438 22125-22127 IN denotes of
T18439 22128-22136 JJ denotes synovial
T18440 22137-22143 JJ denotes lining
T18441 22144-22149 NN denotes cells
T18442 22150-22153 CC denotes and
T18443 22154-22156 DT denotes an
T18444 22157-22164 JJ denotes intense
T18445 22165-22177 NN denotes infiltration
T18446 22178-22180 IN denotes by
T18447 22181-22192 JJ denotes mononuclear
T18448 22193-22198 NN denotes cells
T18449 22199-22200 -LRB- denotes [
T18450 22200-22202 CD denotes 23
T18451 22202-22203 -RRB- denotes ]
T18452 22205-22220 JJ denotes Proinflammatory
T18453 22221-22230 NN denotes cytokines
T18454 22231-22235 JJ denotes such
T18455 22236-22238 IN denotes as
T18456 22239-22243 NN denotes IL-1
T18457 22244-22247 CC denotes and
T18458 22248-22253 NN denotes TNF-α
T18459 22254-22257 VB denotes are
T18460 22258-22266 JJ denotes abundant
T18461 22267-22269 IN denotes in
T18462 22270-22280 JJ denotes rheumatoid
T18463 22281-22289 NN denotes synovium
T18464 22289-22290 -COMMA- denotes ,
T18465 22291-22298 IN denotes whereas
T18466 22299-22302 DT denotes the
T18467 22303-22304 NN denotes T
T18468 22305-22317 JJ denotes cell-derived
T18469 22318-22327 NN denotes cytokines
T18470 22327-22328 -COMMA- denotes ,
T18471 22329-22339 RB denotes especially
T18472 22340-22344 NN denotes IL-4
T18473 22345-22348 CC denotes and
T18474 22349-22361 NN denotes interferon-γ
T18475 22361-22362 -COMMA- denotes ,
T18476 22363-22367 VB denotes have
T18477 22368-22373 RB denotes often
T18478 22374-22380 VB denotes proved
T18479 22381-22390 JJ denotes difficult
T18480 22391-22393 TO denotes to
T18481 22394-22400 VB denotes detect
T18482 22401-22403 IN denotes in
T18483 22404-22406 NN denotes RA
T18484 22407-22415 NN denotes synovium
T18485 22416-22417 -LRB- denotes [
T18486 22417-22419 CD denotes 24
T18487 22419-22420 -RRB- denotes ]
T18488 22422-22430 IN denotes Although
T18489 22431-22432 NN denotes T
T18490 22433-22438 NN denotes cells
T18491 22439-22442 MD denotes may
T18492 22443-22447 VB denotes have
T18493 22448-22449 DT denotes a
T18494 22450-22454 NN denotes role
T18495 22455-22457 IN denotes in
T18496 22458-22461 DT denotes the
T18497 22462-22474 NN denotes augmentation
T18498 22475-22477 IN denotes of
T18499 22478-22488 JJ denotes rheumatoid
T18500 22489-22497 JJ denotes synovial
T18501 22498-22510 NN denotes inflammation
T18502 22510-22511 -COMMA- denotes ,
T18503 22512-22515 DT denotes the
T18504 22516-22520 NN denotes lack
T18505 22521-22523 IN denotes of
T18506 22524-22525 NN denotes T
T18507 22526-22538 JJ denotes cell-derived
T18508 22539-22548 NN denotes cytokines
T18509 22549-22552 VB denotes has
T18510 22553-22560 VB denotes limited
T18511 22561-22564 PRP-DOLLAR- denotes its
T18512 22565-22575 NN denotes importance
T18513 22577-22579 IN denotes In
T18514 22580-22584 DT denotes this
T18515 22585-22592 NN denotes respect
T18516 22592-22593 -COMMA- denotes ,
T18517 22594-22599 NN denotes IL-17
T18518 22600-22602 VB denotes is
T18519 22603-22612 VB denotes appealing
T18520 22613-22620 IN denotes because
T18521 22621-22623 PRP denotes it
T18522 22624-22627 VB denotes has
T18523 22628-22632 VB denotes been
T18524 22633-22642 VB denotes described
T18525 22643-22645 IN denotes as
T18526 22646-22647 DT denotes a
T18527 22648-22649 NN denotes T
T18528 22650-22662 JJ denotes cell-derived
T18529 22663-22671 NN denotes cytokine
T18530 22672-22676 IN denotes with
T18531 22677-22692 JJ denotes proinflammatory
T18532 22693-22703 NN denotes properties
T18533 22705-22707 IN denotes In
T18534 22708-22711 PRP-DOLLAR- denotes our
T18535 22712-22719 NN denotes studies
T18536 22719-22720 -COMMA- denotes ,
T18537 22721-22723 PRP denotes we
T18538 22724-22729 VB denotes tried
T18539 22730-22732 TO denotes to
T18540 22733-22741 VB denotes evaluate
T18541 22742-22745 WRB denotes how
T18542 22746-22751 NN denotes IL-17
T18543 22752-22762 NN denotes production
T18544 22763-22765 VB denotes is
T18545 22766-22775 VB denotes regulated
T18546 22776-22778 IN denotes in
T18547 22779-22781 NN denotes RA
T18548 22782-22786 NN denotes PBMC
T18549 22786-22787 -COMMA- denotes ,
T18550 22788-22791 CC denotes and
T18551 22792-22797 WDT denotes which
T18552 22798-22807 NN denotes signaling
T18553 22808-22815 NN denotes pathway
T18554 22816-22818 PRP denotes it
T18555 22819-22823 VB denotes used
T18556 22825-22831 NN denotes Levels
T18557 22832-22834 IN denotes of
T18558 22835-22840 NN denotes IL-17
T18559 22841-22845 VB denotes were
T18560 22846-22851 VB denotes found
T18561 22852-22854 TO denotes to
T18562 22855-22857 VB denotes be
T18563 22858-22864 JJ denotes higher
T18564 22865-22867 IN denotes in
T18565 22868-22870 NN denotes RA
T18566 22871-22879 JJ denotes synovial
T18567 22880-22885 NN denotes fluid
T18568 22886-22890 IN denotes than
T18569 22891-22893 IN denotes in
T18570 22894-22896 NN denotes OA
T18571 22897-22905 JJ denotes synovial
T18572 22906-22911 NN denotes fluid
T18573 22912-22913 -LRB- denotes [
T18574 22913-22915 CD denotes 15
T18575 22915-22916 -RRB- denotes ]
T18576 22918-22925 RB denotes However
T18577 22925-22926 -COMMA- denotes ,
T18578 22927-22932 EX denotes there
T18579 22933-22936 VB denotes are
T18580 22937-22940 JJ denotes few
T18581 22941-22945 NN denotes data
T18582 22946-22955 JJ denotes available
T18583 22956-22958 IN denotes on
T18584 22959-22962 DT denotes the
T18585 22963-22969 NN denotes agents
T18586 22970-22974 WDT denotes that
T18587 22975-22984 VB denotes stimulate
T18588 22985-22990 NN denotes IL-17
T18589 22991-23001 NN denotes production
T18590 23002-23004 IN denotes in
T18591 23005-23007 NN denotes RA
T18592 23007-23008 -COMMA- denotes ,
T18593 23009-23017 IN denotes although
T18594 23018-23021 DT denotes the
T18595 23022-23029 JJ denotes highest
T18596 23030-23035 NN denotes level
T18597 23036-23038 IN denotes of
T18598 23039-23044 NN denotes IL-17
T18599 23045-23055 NN denotes production
T18600 23056-23059 MD denotes can
T18601 23060-23062 VB denotes be
T18602 23063-23071 VB denotes achieved
T18603 23072-23074 IN denotes by
T18604 23075-23093 JJ denotes anti-CD3/anti-CD28
T18605 23094-23105 NN denotes stimulation
T18606 23106-23108 IN denotes in
T18607 23109-23116 JJ denotes healthy
T18608 23117-23128 NN denotes individuals
T18609 23129-23130 -LRB- denotes [
T18610 23130-23132 CD denotes 25
T18611 23132-23133 -RRB- denotes ]
T18612 23135-23137 IN denotes In
T18613 23138-23141 PRP-DOLLAR- denotes our
T18614 23142-23153 NN denotes experiments
T18615 23153-23154 -COMMA- denotes ,
T18616 23155-23158 NN denotes PHA
T18617 23159-23161 IN denotes as
T18618 23162-23170 NN denotes mitogens
T18619 23170-23171 -COMMA- denotes ,
T18620 23172-23174 RB denotes as
T18621 23175-23179 RB denotes well
T18622 23180-23182 IN denotes as
T18623 23183-23201 JJ denotes anti-CD3/anti-CD28
T18624 23202-23205 IN denotes for
T18625 23206-23215 NN denotes signaling
T18626 23216-23223 IN denotes through
T18627 23224-23227 DT denotes the
T18628 23228-23229 NN denotes T
T18629 23230-23234 NN denotes cell
T18630 23235-23243 NN denotes receptor
T18631 23243-23244 -COMMA- denotes ,
T18632 23245-23254 VB denotes increased
T18633 23255-23260 NN denotes IL-17
T18634 23261-23271 NN denotes production
T18635 23272-23276 IN denotes from
T18636 23277-23279 NN denotes RA
T18637 23280-23284 NN denotes PBMC
T18638 23285-23287 IN denotes in
T18639 23288-23289 DT denotes a
T18640 23290-23304 JJ denotes dose-dependent
T18641 23305-23311 NN denotes manner
T18642 23313-23315 PRP denotes We
T18643 23316-23321 VB denotes found
T18644 23321-23322 -COMMA- denotes ,
T18645 23323-23325 IN denotes by
T18646 23326-23327 DT denotes a
T18647 23328-23332 NN denotes cell
T18648 23333-23346 NN denotes proliferation
T18649 23347-23352 NN denotes assay
T18650 23353-23354 -LRB- denotes (
T18651 23354-23358 NN denotes data
T18652 23359-23362 RB denotes not
T18653 23363-23368 VB denotes shown
T18654 23368-23369 -RRB- denotes )
T18655 23369-23370 -COMMA- denotes ,
T18656 23371-23375 IN denotes that
T18657 23376-23380 DT denotes this
T18658 23381-23393 NN denotes upregulation
T18659 23394-23396 IN denotes of
T18660 23397-23402 NN denotes IL-17
T18661 23403-23408 MD denotes might
T18662 23409-23411 VB denotes be
T18663 23412-23415 JJ denotes due
T18664 23416-23418 TO denotes to
T18665 23419-23428 VB denotes increased
T18666 23429-23437 JJ denotes cellular
T18667 23438-23446 NN denotes activity
T18668 23447-23453 RB denotes rather
T18669 23454-23458 IN denotes than
T18670 23459-23461 TO denotes to
T18671 23462-23470 JJ denotes cellular
T18672 23471-23484 NN denotes proliferation
T18673 23486-23491 NN denotes IL-17
T18674 23492-23494 VB denotes is
T18675 23495-23503 VB denotes produced
T18676 23504-23510 RB denotes mainly
T18677 23511-23513 IN denotes by
T18678 23514-23523 VB denotes activated
T18679 23524-23528 JJ denotes CD4+
T18680 23529-23530 NN denotes T
T18681 23531-23536 NN denotes cells
T18682 23536-23537 -COMMA- denotes ,
T18683 23538-23548 RB denotes especially
T18684 23549-23552 IN denotes for
T18685 23553-23560 NN denotes Th1/Th0
T18686 23561-23566 NN denotes cells
T18687 23566-23567 -COMMA- denotes ,
T18688 23568-23571 RB denotes not
T18689 23572-23575 DT denotes the
T18690 23576-23579 NN denotes Th2
T18691 23580-23589 NN denotes phenotype
T18692 23590-23591 -LRB- denotes [
T18693 23591-23593 CD denotes 26
T18694 23593-23594 -RRB- denotes ]
T18695 23596-23603 RB denotes However
T18696 23603-23604 -COMMA- denotes ,
T18697 23605-23607 PRP denotes it
T18698 23608-23611 MD denotes can
T18699 23612-23616 RB denotes also
T18700 23617-23619 VB denotes be
T18701 23620-23628 VB denotes produced
T18702 23629-23631 IN denotes by
T18703 23632-23636 JJ denotes CD8+
T18704 23637-23638 NN denotes T
T18705 23639-23644 NN denotes cells
T18706 23645-23648 IN denotes via
T18707 23649-23651 DT denotes an
T18708 23652-23657 NN denotes IL-23
T18709 23658-23668 NN denotes triggering
T18710 23669-23678 NN denotes mechanism
T18711 23679-23681 IN denotes in
T18712 23682-23695 JJ denotes Gram-negative
T18713 23696-23705 JJ denotes pulmonary
T18714 23706-23715 NN denotes infection
T18715 23716-23717 -LRB- denotes [
T18716 23717-23719 CD denotes 14
T18717 23719-23720 -RRB- denotes ]
T18718 23722-23724 IN denotes In
T18719 23725-23733 NN denotes addition
T18720 23733-23734 -COMMA- denotes ,
T18721 23735-23740 NN denotes IL-17
T18722 23741-23751 NN denotes production
T18723 23752-23755 VB denotes was
T18724 23756-23769 RB denotes significantly
T18725 23770-23779 VB denotes augmented
T18726 23780-23782 IN denotes by
T18727 23783-23784 NN denotes T
T18728 23785-23790 NN denotes cells
T18729 23791-23802 VB denotes recognizing
T18730 23803-23807 NN denotes type
T18731 23808-23810 CD denotes II
T18732 23811-23819 NN denotes collagen
T18733 23820-23822 IN denotes in
T18734 23823-23824 DT denotes a
T18735 23825-23841 JJ denotes collagen-induced
T18736 23842-23851 NN denotes arthritis
T18737 23852-23857 NN denotes model
T18738 23858-23859 -LRB- denotes [
T18739 23859-23861 CD denotes 27
T18740 23861-23862 -RRB- denotes ]
T18741 23864-23865 DT denotes A
T18742 23866-23873 JJ denotes complex
T18743 23874-23885 NN denotes interaction
T18744 23886-23893 IN denotes between
T18745 23894-23899 NN denotes cells
T18746 23900-23902 IN denotes in
T18747 23903-23911 JJ denotes inflamed
T18748 23912-23914 NN denotes RA
T18749 23915-23921 NN denotes joints
T18750 23922-23927 MD denotes might
T18751 23928-23935 VB denotes produce
T18752 23936-23937 DT denotes a
T18753 23938-23945 NN denotes variety
T18754 23946-23948 IN denotes of
T18755 23949-23964 JJ denotes proinflammatory
T18756 23965-23974 NN denotes cytokines
T18757 23975-23978 CC denotes and
T18758 23979-23989 NN denotes chemokines
T18759 23989-23990 -COMMA- denotes ,
T18760 23991-23996 WDT denotes which
T18761 23997-24001 RB denotes also
T18762 24002-24010 VB denotes activate
T18763 24011-24016 JJ denotes other
T18764 24017-24022 NN denotes cells
T18765 24023-24025 IN denotes in
T18766 24026-24029 DT denotes the
T18767 24030-24036 NN denotes joints
T18768 24038-24041 IN denotes For
T18769 24042-24049 NN denotes example
T18770 24049-24050 -COMMA- denotes ,
T18771 24051-24056 NN denotes IL-17
T18772 24057-24067 VB denotes stimulates
T18773 24068-24078 JJ denotes rheumatoid
T18774 24079-24091 NN denotes synoviocytes
T18775 24092-24094 TO denotes to
T18776 24095-24102 VB denotes secrete
T18777 24103-24110 JJ denotes several
T18778 24111-24120 NN denotes cytokines
T18779 24121-24125 JJ denotes such
T18780 24126-24128 IN denotes as
T18781 24129-24133 NN denotes IL-6
T18782 24133-24134 -COMMA- denotes ,
T18783 24135-24139 NN denotes IL-8
T18784 24140-24143 CC denotes and
T18785 24144-24149 NN denotes tumor
T18786 24150-24158 NN denotes necrosis
T18787 24159-24176 JJ denotes factor-stimulated
T18788 24177-24181 NN denotes gene
T18789 24182-24183 CD denotes 6
T18790 24184-24186 RB denotes as
T18791 24187-24191 RB denotes well
T18792 24192-24194 IN denotes as
T18793 24195-24208 NN denotes prostaglandin
T18794 24209-24211 NN denotes E2
T18795 24212-24214 FW denotes in
T18796 24215-24220 FW denotes vitro
T18797 24221-24222 -LRB- denotes [
T18798 24222-24230 CD denotes 12,28,29
T18799 24230-24231 -RRB- denotes ]
T18800 24233-24238 EX denotes There
T18801 24239-24242 VB denotes are
T18802 24243-24245 RB denotes as
T18803 24246-24249 RB denotes yet
T18804 24250-24253 JJ denotes few
T18805 24254-24258 NN denotes data
T18806 24259-24268 JJ denotes available
T18807 24269-24271 IN denotes on
T18808 24272-24275 DT denotes the
T18809 24276-24282 NN denotes agents
T18810 24283-24287 WDT denotes that
T18811 24288-24297 VB denotes stimulate
T18812 24298-24303 NN denotes IL-17
T18813 24304-24314 NN denotes production
T18814 24315-24317 IN denotes in
T18815 24318-24320 NN denotes RA
T18816 24320-24321 -COMMA- denotes ,
T18817 24322-24330 IN denotes although
T18818 24331-24335 DT denotes some
T18819 24336-24345 NN denotes cytokines
T18820 24346-24347 -LRB- denotes (
T18821 24347-24352 NN denotes IL-15
T18822 24353-24356 CC denotes and
T18823 24357-24362 NN denotes IL-23
T18824 24362-24363 -RRB- denotes )
T18825 24364-24368 VB denotes have
T18826 24369-24373 VB denotes been
T18827 24374-24379 VB denotes known
T18828 24380-24382 TO denotes to
T18829 24383-24391 VB denotes regulate
T18830 24392-24397 NN denotes IL-17
T18831 24398-24408 NN denotes production
T18832 24409-24410 -LRB- denotes [
T18833 24410-24415 CD denotes 13,14
T18834 24415-24416 -RRB- denotes ]
T18835 24418-24420 PRP denotes We
T18836 24421-24430 RB denotes therefore
T18837 24431-24443 VB denotes investigated
T18838 24444-24447 DT denotes the
T18839 24448-24450 FW denotes in
T18840 24451-24456 FW denotes vitro
T18841 24457-24467 NN denotes production
T18842 24468-24470 IN denotes of
T18843 24471-24476 NN denotes IL-17
T18844 24477-24479 IN denotes in
T18845 24480-24482 NN denotes RA
T18846 24483-24487 NN denotes PBMC
T18847 24488-24498 VB denotes responding
T18848 24499-24501 TO denotes to
T18849 24502-24503 DT denotes a
T18850 24504-24511 NN denotes variety
T18851 24512-24514 IN denotes of
T18852 24515-24535 NN denotes cytokines/chemokines
T18853 24536-24539 CC denotes and
T18854 24540-24548 NN denotes mitogens
T18855 24549-24551 RB denotes as
T18856 24552-24556 RB denotes well
T18857 24557-24559 IN denotes as
T18858 24560-24561 NN denotes T
T18859 24562-24566 NN denotes cell
T18860 24567-24575 NN denotes receptor
T18861 24576-24577 -LRB- denotes (
T18862 24577-24580 NN denotes TCR
T18863 24580-24581 -RRB- denotes )
T18864 24582-24590 NN denotes ligation
T18865 24591-24596 VB denotes using
T18866 24597-24615 JJ denotes anti-CD3/anti-CD28
T18867 24617-24620 PRP-DOLLAR- denotes Our
T18868 24621-24628 NN denotes studies
T18869 24629-24641 VB denotes demonstrated
T18870 24642-24646 IN denotes that
T18871 24647-24652 NN denotes IL-15
T18872 24653-24656 CC denotes and
T18873 24657-24662 NN denotes MCP-1
T18874 24663-24665 RB denotes as
T18875 24666-24670 RB denotes well
T18876 24671-24673 IN denotes as
T18877 24674-24677 NN denotes TCR
T18878 24678-24686 NN denotes ligation
T18879 24687-24700 RB denotes significantly
T18880 24701-24710 VB denotes increased
T18881 24711-24714 DT denotes the
T18882 24715-24725 NN denotes production
T18883 24726-24728 IN denotes of
T18884 24729-24734 NN denotes IL-17
T18885 24735-24737 IN denotes in
T18886 24738-24740 NN denotes RA
T18887 24741-24745 NN denotes PBMC
T18888 24747-24753 VB denotes Adding
T18889 24754-24759 NN denotes IL-15
T18890 24760-24762 CC denotes or
T18891 24763-24768 NN denotes MCP-1
T18892 24769-24771 TO denotes to
T18893 24772-24775 NN denotes TCR
T18894 24776-24784 NN denotes ligation
T18895 24785-24794 VB denotes augmented
T18896 24795-24800 NN denotes IL-17
T18897 24801-24811 NN denotes production
T18898 24812-24816 RB denotes more
T18899 24817-24825 RB denotes markedly
T18900 24827-24829 IN denotes In
T18901 24830-24838 NN denotes contrast
T18902 24838-24839 -COMMA- denotes ,
T18903 24840-24844 NN denotes IL-1
T18904 24845-24848 CC denotes and
T18905 24849-24854 NN denotes TNF-α
T18906 24854-24855 -COMMA- denotes ,
T18907 24856-24861 WDT denotes which
T18908 24862-24865 VB denotes are
T18909 24866-24871 VB denotes known
T18910 24872-24874 TO denotes to
T18911 24875-24879 VB denotes have
T18912 24880-24895 JJ denotes proinflammatory
T18913 24896-24906 NN denotes properties
T18914 24907-24910 CC denotes and
T18915 24911-24913 TO denotes to
T18916 24914-24916 VB denotes be
T18917 24917-24926 VB denotes increased
T18918 24927-24929 IN denotes in
T18919 24930-24932 NN denotes RA
T18920 24933-24939 NN denotes joints
T18921 24939-24940 -COMMA- denotes ,
T18922 24941-24944 VB denotes did
T18923 24945-24948 RB denotes not
T18924 24949-24955 VB denotes affect
T18925 24956-24961 NN denotes IL-17
T18926 24962-24972 NN denotes production
T18927 24974-24977 PRP-DOLLAR- denotes Our
T18928 24978-24982 NN denotes data
T18929 24983-24987 VB denotes were
T18930 24988-24998 JJ denotes consistent
T18931 24999-25003 IN denotes with
T18932 25004-25005 DT denotes a
T18933 25006-25012 JJ denotes recent
T18934 25013-25019 NN denotes report
T18935 25020-25024 IN denotes that
T18936 25025-25030 NN denotes IL-15
T18937 25031-25040 VB denotes triggered
T18938 25041-25043 FW denotes in
T18939 25044-25049 FW denotes vitro
T18940 25050-25055 NN denotes IL-17
T18941 25056-25066 NN denotes production
T18942 25067-25069 IN denotes in
T18943 25070-25074 NN denotes PBMC
T18944 25074-25075 -COMMA- denotes ,
T18945 25076-25079 CC denotes but
T18946 25080-25085 NN denotes TNF-α
T18947 25086-25089 VB denotes did
T18948 25090-25093 RB denotes not
T18949 25094-25096 VB denotes do
T18950 25097-25099 RB denotes so
T18951 25100-25101 -LRB- denotes [
T18952 25101-25103 CD denotes 13
T18953 25103-25104 -RRB- denotes ]
T18954 25106-25114 IN denotes Although
T18955 25115-25120 EX denotes there
T18956 25121-25125 VB denotes were
T18957 25126-25128 DT denotes no
T18958 25129-25133 NN denotes data
T18959 25134-25138 IN denotes that
T18960 25139-25144 NN denotes MCP-1
T18961 25145-25153 RB denotes directly
T18962 25154-25161 VB denotes induces
T18963 25162-25163 NN denotes T
T18964 25164-25168 NN denotes cell
T18965 25169-25179 NN denotes activation
T18966 25179-25180 -COMMA- denotes ,
T18967 25181-25183 PRP denotes it
T18968 25184-25189 MD denotes might
T18969 25190-25195 VB denotes exert
T18970 25196-25203 NN denotes effects
T18971 25204-25214 RB denotes indirectly
T18972 25215-25217 IN denotes on
T18973 25218-25219 NN denotes T
T18974 25220-25225 NN denotes cells
T18975 25226-25233 IN denotes through
T18976 25234-25237 DT denotes the
T18977 25238-25248 NN denotes activation
T18978 25249-25251 IN denotes of
T18979 25252-25273 NN denotes monocytes/macrophages
T18980 25274-25276 IN denotes in
T18981 25277-25281 NN denotes PBMC
T18982 25282-25290 NN denotes cultures
T18983 25292-25294 IN denotes As
T18984 25295-25303 VB denotes reported
T18985 25304-25307 IN denotes for
T18986 25308-25314 JJ denotes normal
T18987 25315-25326 NN denotes individuals
T18988 25327-25328 -LRB- denotes [
T18989 25328-25330 CD denotes 25
T18990 25330-25331 -RRB- denotes ]
T18991 25331-25332 -COMMA- denotes ,
T18992 25333-25334 NN denotes T
T18993 25335-25339 NN denotes cell
T18994 25340-25350 NN denotes activation
T18995 25351-25358 IN denotes through
T18996 25359-25377 JJ denotes anti-CD3/anti-CD28
T18997 25378-25382 RB denotes also
T18998 25383-25392 VB denotes increases
T18999 25393-25398 NN denotes IL-17
T19000 25399-25408 NN denotes induction
T19001 25409-25411 IN denotes in
T19002 25412-25414 NN denotes RA
T19003 25415-25419 NN denotes PBMC
T19004 25421-25429 IN denotes Although
T19005 25430-25433 DT denotes the
T19006 25434-25443 NN denotes signaling
T19007 25444-25451 NN denotes pathway
T19008 25452-25455 IN denotes for
T19009 25456-25459 DT denotes the
T19010 25460-25469 NN denotes induction
T19011 25470-25472 IN denotes of
T19012 25473-25493 NN denotes cytokines/chemokines
T19013 25494-25496 IN denotes by
T19014 25497-25502 NN denotes IL-17
T19015 25503-25506 VB denotes has
T19016 25507-25511 VB denotes been
T19017 25512-25522 VB denotes documented
T19018 25523-25529 RB denotes widely
T19019 25530-25531 -LRB- denotes [
T19020 25531-25538 CD denotes 8,30,31
T19021 25538-25539 -RRB- denotes ]
T19022 25539-25540 -COMMA- denotes ,
T19023 25541-25543 DT denotes no
T19024 25544-25548 NN denotes data
T19025 25549-25553 VB denotes have
T19026 25554-25558 VB denotes been
T19027 25559-25568 JJ denotes available
T19028 25569-25571 IN denotes on
T19029 25572-25575 WRB denotes how
T19030 25576-25581 NN denotes IL-17
T19031 25582-25592 NN denotes production
T19032 25593-25596 MD denotes can
T19033 25597-25599 VB denotes be
T19034 25600-25609 VB denotes regulated
T19035 25610-25612 IN denotes by
T19036 25613-25620 JJ denotes certain
T19037 25621-25630 NN denotes signaling
T19038 25631-25639 NN denotes pathways
T19039 25641-25643 IN denotes By
T19040 25644-25649 VB denotes using
T19041 25650-25656 NN denotes signal
T19042 25657-25669 NN denotes transduction
T19043 25670-25680 NN denotes inhibitors
T19044 25680-25681 -COMMA- denotes ,
T19045 25682-25684 PRP denotes we
T19046 25685-25694 RB denotes therefore
T19047 25695-25703 VB denotes examined
T19048 25704-25709 WDT denotes which
T19049 25710-25719 NN denotes signaling
T19050 25720-25727 NN denotes pathway
T19051 25728-25731 VB denotes was
T19052 25732-25738 RB denotes mainly
T19053 25739-25747 VB denotes involved
T19054 25748-25750 IN denotes in
T19055 25751-25754 DT denotes the
T19056 25755-25764 NN denotes induction
T19057 25765-25767 IN denotes of
T19058 25768-25773 NN denotes IL-17
T19059 25774-25776 IN denotes in
T19060 25777-25779 NN denotes RA
T19061 25780-25784 NN denotes PBMC
T19062 25786-25788 PRP denotes We
T19063 25789-25799 VB denotes identified
T19064 25800-25804 IN denotes that
T19065 25805-25821 JJ denotes anti-CD3-induced
T19066 25822-25827 NN denotes IL-17
T19067 25828-25838 NN denotes production
T19068 25839-25841 IN denotes in
T19069 25842-25844 NN denotes RA
T19070 25845-25849 NN denotes PBMC
T19071 25850-25853 VB denotes was
T19072 25854-25867 RB denotes significantly
T19073 25868-25876 VB denotes hampered
T19074 25877-25879 IN denotes by
T19075 25880-25883 DT denotes the
T19076 25884-25888 NN denotes PI3K
T19077 25889-25898 NN denotes inhibitor
T19078 25899-25907 NN denotes LY294002
T19079 25908-25911 CC denotes and
T19080 25912-25915 DT denotes the
T19081 25916-25921 NN denotes NF-κB
T19082 25922-25931 NN denotes inhibitor
T19083 25932-25936 NN denotes PDTC
T19084 25937-25939 TO denotes to
T19085 25940-25950 JJ denotes comparable
T19086 25951-25957 NN denotes levels
T19087 25958-25960 IN denotes of
T19088 25961-25966 JJ denotes basal
T19089 25967-25977 NN denotes production
T19090 25978-25985 IN denotes without
T19091 25986-25997 NN denotes stimulation
T19092 25999-26001 PRP denotes We
T19093 26002-26006 RB denotes also
T19094 26007-26012 VB denotes found
T19095 26013-26017 IN denotes that
T19096 26018-26034 JJ denotes anti-CD3-induced
T19097 26035-26040 NN denotes IL-17
T19098 26041-26051 NN denotes production
T19099 26052-26055 VB denotes was
T19100 26056-26069 VB denotes downregulated
T19101 26070-26072 IN denotes by
T19102 26073-26076 DT denotes the
T19103 26077-26085 NN denotes addition
T19104 26086-26088 IN denotes of
T19105 26089-26097 NN denotes SB203580
T19106 26097-26098 -COMMA- denotes ,
T19107 26099-26100 DT denotes a
T19108 26101-26104 NN denotes p38
T19109 26105-26109 NN denotes MAPK
T19110 26110-26119 NN denotes inhibitor
T19111 26121-26123 PRP denotes It
T19112 26124-26126 VB denotes is
T19113 26127-26138 JJ denotes interesting
T19114 26139-26143 IN denotes that
T19115 26144-26145 DT denotes a
T19116 26146-26152 NN denotes series
T19117 26153-26155 IN denotes of
T19118 26156-26164 NN denotes evidence
T19119 26165-26173 VB denotes supports
T19120 26174-26183 NN denotes crosstalk
T19121 26184-26191 IN denotes between
T19122 26192-26197 NN denotes NF-κB
T19123 26198-26201 CC denotes and
T19124 26202-26205 NN denotes p38
T19125 26207-26209 IN denotes In
T19126 26210-26218 NN denotes myocytes
T19127 26218-26219 -COMMA- denotes ,
T19128 26220-26223 NN denotes IκB
T19129 26224-26232 NN denotes kinase-β
T19130 26233-26235 VB denotes is
T19131 26236-26245 VB denotes activated
T19132 26246-26248 IN denotes by
T19133 26249-26252 NN denotes p38
T19134 26253-26254 -LRB- denotes [
T19135 26254-26256 CD denotes 32
T19136 26256-26257 -RRB- denotes ]
T19137 26257-26258 -COMMA- denotes ,
T19138 26259-26262 CC denotes and
T19139 26263-26266 DT denotes the
T19140 26267-26276 VB denotes activated
T19141 26277-26280 NN denotes p38
T19142 26281-26284 MD denotes can
T19143 26285-26294 VB denotes stimulate
T19144 26295-26300 NN denotes NF-κB
T19145 26301-26303 IN denotes by
T19146 26304-26305 DT denotes a
T19147 26306-26315 NN denotes mechanism
T19148 26316-26325 VB denotes involving
T19149 26326-26333 NN denotes histone
T19150 26334-26343 NN denotes acetylase
T19151 26344-26361 JJ denotes p300/CREB-binding
T19152 26362-26369 NN denotes protein
T19153 26370-26371 -LRB- denotes [
T19154 26371-26373 CD denotes 33
T19155 26373-26374 -RRB- denotes ]
T19156 26376-26379 PRP-DOLLAR- denotes Our
T19157 26380-26387 NN denotes results
T19158 26388-26396 VB denotes revealed
T19159 26397-26401 IN denotes that
T19160 26402-26405 NN denotes p38
T19161 26406-26410 NN denotes MAPK
T19162 26411-26421 NN denotes activation
T19163 26422-26425 VB denotes was
T19164 26426-26429 RB denotes not
T19165 26430-26438 VB denotes affected
T19166 26439-26441 IN denotes by
T19167 26442-26450 NN denotes LY294002
T19168 26450-26451 -COMMA- denotes ,
T19169 26452-26459 IN denotes whereas
T19170 26460-26465 NN denotes NF-κB
T19171 26466-26473 NN denotes binding
T19172 26474-26482 NN denotes activity
T19173 26483-26486 VB denotes was
T19174 26487-26496 VB denotes decreased
T19175 26497-26499 IN denotes by
T19176 26500-26508 NN denotes LY294002
T19177 26508-26509 -COMMA- denotes ,
T19178 26510-26515 WDT denotes which
T19179 26516-26524 VB denotes provided
T19180 26525-26528 DT denotes the
T19181 26529-26537 NN denotes evidence
T19182 26538-26541 IN denotes for
T19183 26542-26543 DT denotes a
T19184 26544-26547 NN denotes p38
T19185 26548-26552 NN denotes MAPK
T19186 26553-26560 NN denotes pathway
T19187 26561-26572 JJ denotes independent
T19188 26573-26575 IN denotes of
T19189 26576-26580 NN denotes PI3K
T19190 26581-26591 NN denotes activation
T19191 26593-26596 DT denotes The
T19192 26597-26603 JJ denotes direct
T19193 26604-26616 NN denotes relationship
T19194 26617-26624 IN denotes between
T19195 26625-26628 NN denotes p38
T19196 26629-26632 CC denotes and
T19197 26633-26638 NN denotes NF-κB
T19198 26639-26642 IN denotes for
T19199 26643-26648 NN denotes IL-17
T19200 26649-26659 NN denotes production
T19201 26660-26665 VB denotes needs
T19202 26666-26668 TO denotes to
T19203 26669-26671 VB denotes be
T19204 26672-26679 VB denotes studied
T19205 26680-26682 IN denotes in
T19206 26683-26689 JJ denotes future
T19207 26690-26701 NN denotes experiments
T19208 26703-26706 DT denotes The
T19209 26707-26713 NN denotes search
T19210 26714-26717 IN denotes for
T19211 26718-26719 DT denotes a
T19212 26720-26730 JJ denotes downstream
T19213 26731-26738 NN denotes pathway
T19214 26739-26741 IN denotes of
T19215 26742-26746 NN denotes PI3K
T19216 26747-26753 VB denotes seemed
T19217 26754-26756 TO denotes to
T19218 26757-26761 VB denotes have
T19219 26762-26763 DT denotes a
T19220 26764-26771 JJ denotes maximal
T19221 26772-26780 NN denotes response
T19222 26781-26783 IN denotes of
T19223 26784-26787 NN denotes Akt
T19224 26788-26798 NN denotes activation
T19225 26799-26801 IN denotes at
T19226 26802-26803 CD denotes 1
T19227 26804-26808 NN denotes hour
T19228 26809-26812 CC denotes and
T19229 26813-26814 DT denotes a
T19230 26815-26822 JJ denotes gradual
T19231 26823-26827 NN denotes loss
T19232 26828-26830 IN denotes of
T19233 26831-26839 NN denotes activity
T19234 26840-26842 IN denotes at
T19235 26843-26844 CD denotes 2
T19236 26845-26850 NN denotes hours
T19237 26852-26855 DT denotes The
T19238 26856-26860 NN denotes fact
T19239 26861-26865 IN denotes that
T19240 26866-26869 NN denotes Akt
T19241 26870-26872 VB denotes is
T19242 26873-26887 VB denotes phosphorylated
T19243 26888-26892 IN denotes upon
T19244 26893-26901 JJ denotes anti-CD3
T19245 26902-26913 NN denotes stimulation
T19246 26914-26922 VB denotes suggests
T19247 26923-26926 DT denotes the
T19248 26927-26935 JJ denotes possible
T19249 26936-26947 NN denotes involvement
T19250 26948-26950 IN denotes of
T19251 26951-26955 NN denotes PI3K
T19252 26956-26958 IN denotes in
T19253 26959-26962 DT denotes the
T19254 26963-26972 NN denotes induction
T19255 26973-26975 IN denotes of
T19256 26976-26981 NN denotes IL-17
T19257 26982-26984 IN denotes in
T19258 26985-26987 NN denotes RA
T19259 26989-26991 IN denotes In
T19260 26992-26996 NN denotes view
T19261 26997-26999 IN denotes of
T19262 27000-27003 DT denotes the
T19263 27004-27008 NN denotes fact
T19264 27009-27013 IN denotes that
T19265 27014-27019 NN denotes NF-κB
T19266 27020-27023 VB denotes was
T19267 27024-27028 RB denotes also
T19268 27029-27038 VB denotes activated
T19269 27039-27041 IN denotes by
T19270 27042-27060 JJ denotes anti-CD3/anti-CD28
T19271 27060-27061 -COMMA- denotes ,
T19272 27062-27067 NN denotes IL-15
T19273 27068-27070 CC denotes or
T19274 27071-27079 NN denotes mitogens
T19275 27080-27082 IN denotes in
T19276 27083-27086 PRP-DOLLAR- denotes our
T19277 27087-27098 NN denotes experiments
T19278 27098-27099 -COMMA- denotes ,
T19279 27100-27102 PRP denotes it
T19280 27103-27105 VB denotes is
T19281 27106-27110 RB denotes most
T19282 27111-27117 JJ denotes likely
T19283 27118-27122 IN denotes that
T19284 27123-27126 DT denotes the
T19285 27127-27132 NN denotes NF-κB
T19286 27133-27140 NN denotes pathway
T19287 27141-27143 VB denotes is
T19288 27144-27148 RB denotes also
T19289 27149-27157 RB denotes actively
T19290 27158-27166 VB denotes involved
T19291 27167-27169 IN denotes in
T19292 27170-27173 DT denotes the
T19293 27174-27183 NN denotes induction
T19294 27184-27186 IN denotes of
T19295 27187-27192 NN denotes IL-17
T19296 27193-27195 IN denotes in
T19297 27196-27198 NN denotes RA
T19298 27199-27203 NN denotes PBMC
T19299 27205-27207 IN denotes In
T19300 27208-27216 NN denotes contrast
T19301 27216-27217 -COMMA- denotes ,
T19302 27218-27221 DT denotes the
T19303 27222-27226 NN denotes AP-1
T19304 27227-27233 NN denotes signal
T19305 27234-27246 NN denotes transduction
T19306 27247-27254 NN denotes pathway
T19307 27254-27255 -COMMA- denotes ,
T19308 27256-27263 DT denotes another
T19309 27264-27273 JJ denotes important
T19310 27274-27283 NN denotes signaling
T19311 27284-27291 NN denotes pathway
T19312 27292-27295 IN denotes for
T19313 27296-27316 NN denotes cytokines/chemokines
T19314 27316-27317 -COMMA- denotes ,
T19315 27318-27321 VB denotes was
T19316 27322-27325 RB denotes not
T19317 27326-27335 VB denotes activated
T19318 27336-27338 IN denotes in
T19319 27339-27342 PRP-DOLLAR- denotes our
T19320 27343-27354 NN denotes experiments
T19321 27355-27356 -LRB- denotes (
T19322 27356-27360 NN denotes data
T19323 27361-27364 RB denotes not
T19324 27365-27370 VB denotes shown
T19325 27370-27371 -RRB- denotes )
T19326 27373-27381 IN denotes Although
T19327 27382-27386 NN denotes PI3K
T19328 27387-27390 CC denotes and
T19329 27391-27394 PRP-DOLLAR- denotes its
T19330 27395-27405 JJ denotes downstream
T19331 27406-27412 NN denotes kinase
T19332 27413-27416 NN denotes Akt
T19333 27417-27419 IN denotes in
T19334 27420-27431 NN denotes association
T19335 27432-27436 IN denotes with
T19336 27437-27442 NN denotes NF-κB
T19337 27443-27447 VB denotes have
T19338 27448-27452 VB denotes been
T19339 27453-27461 VB denotes reported
T19340 27462-27464 TO denotes to
T19341 27465-27472 VB denotes deliver
T19342 27473-27483 VB denotes activating
T19343 27484-27491 NN denotes signals
T19344 27492-27494 IN denotes in
T19345 27495-27499 JJ denotes many
T19346 27500-27504 NN denotes cell
T19347 27505-27510 NN denotes types
T19348 27510-27511 -COMMA- denotes ,
T19349 27512-27515 DT denotes the
T19350 27516-27520 NN denotes data
T19351 27521-27523 IN denotes on
T19352 27524-27527 DT denotes the
T19353 27528-27534 NN denotes signal
T19354 27535-27543 VB denotes inducing
T19355 27544-27549 NN denotes IL-17
T19356 27550-27553 VB denotes are
T19357 27554-27561 VB denotes lacking
T19358 27563-27566 PRP-DOLLAR- denotes Our
T19359 27567-27571 NN denotes data
T19360 27572-27579 RB denotes clearly
T19361 27580-27592 VB denotes demonstrated
T19362 27593-27597 IN denotes that
T19363 27598-27606 NN denotes PI3K/Akt
T19364 27607-27610 CC denotes and
T19365 27611-27620 JJ denotes resultant
T19366 27621-27626 NN denotes NF-κB
T19367 27627-27637 NN denotes activation
T19368 27638-27643 MD denotes could
T19369 27644-27646 VB denotes be
T19370 27647-27649 DT denotes an
T19371 27650-27659 JJ denotes important
T19372 27660-27670 NN denotes arbitrator
T19373 27671-27673 IN denotes of
T19374 27674-27677 DT denotes the
T19375 27678-27690 NN denotes upregulation
T19376 27691-27693 IN denotes of
T19377 27694-27699 NN denotes IL-17
T19378 27700-27702 IN denotes in
T19379 27703-27705 NN denotes RA
T19380 27705-27706 -COMMA- denotes ,
T19381 27707-27709 IN denotes on
T19382 27710-27713 DT denotes the
T19383 27714-27719 NN denotes basis
T19384 27720-27722 IN denotes of
T19385 27723-27726 PRP-DOLLAR- denotes our
T19386 27727-27738 NN denotes experiments
T19387 27739-27746 VB denotes showing
T19388 27747-27759 JJ denotes simultaneous
T19389 27760-27768 NN denotes blocking
T19390 27769-27771 IN denotes of
T19391 27772-27777 NN denotes NF-κB
T19392 27778-27785 NN denotes binding
T19393 27786-27794 NN denotes activity
T19394 27795-27797 IN denotes in
T19395 27798-27801 DT denotes the
T19396 27802-27807 NN denotes IL-17
T19397 27808-27816 NN denotes promoter
T19398 27817-27819 IN denotes by
T19399 27820-27824 NN denotes PDTC
T19400 27825-27828 CC denotes and
T19401 27829-27837 NN denotes LY294002
T19402 27839-27850 VB denotes Considering
T19403 27851-27854 PRP-DOLLAR- denotes its
T19404 27855-27870 JJ denotes proinflammatory
T19405 27871-27881 NN denotes activities
T19406 27882-27885 CC denotes and
T19407 27886-27896 JJ denotes successful
T19408 27897-27906 NN denotes induction
T19409 27907-27909 IN denotes of
T19410 27910-27920 NN denotes anti-IL-17
T19411 27921-27924 IN denotes for
T19412 27925-27937 VB denotes ameliorating
T19413 27938-27947 NN denotes arthritis
T19414 27948-27950 IN denotes in
T19415 27951-27957 NN denotes animal
T19416 27958-27964 NN denotes models
T19417 27965-27966 -LRB- denotes [
T19418 27966-27975 CD denotes 2,6,34-36
T19419 27975-27976 -RRB- denotes ]
T19420 27976-27977 -COMMA- denotes ,
T19421 27978-27991 VB denotes understanding
T19422 27992-27995 DT denotes the
T19423 27996-28001 NN denotes IL-17
T19424 28002-28011 NN denotes signaling
T19425 28012-28019 NN denotes pathway
T19426 28020-28022 VB denotes is
T19427 28023-28025 DT denotes an
T19428 28026-28035 JJ denotes important
T19429 28036-28043 NN denotes element
T19430 28044-28046 IN denotes of
T19431 28047-28057 VB denotes developing
T19432 28058-28061 JJ denotes new
T19433 28062-28070 VB denotes targeted
T19434 28071-28080 NN denotes therapies
T19435 28081-28083 IN denotes in
T19436 28084-28086 NN denotes RA
T22227 28101-28103 PRP denotes We
T22228 28104-28108 VB denotes have
T22229 28109-28117 VB denotes detected
T22230 28118-28119 DT denotes a
T22231 28120-28124 RB denotes more
T22232 28125-28135 JJ denotes pronounced
T22233 28136-28146 NN denotes production
T22234 28147-28149 IN denotes of
T22235 28150-28155 NN denotes IL-17
T22236 28156-28160 IN denotes from
T22237 28161-28163 NN denotes RA
T22238 28164-28168 NN denotes PBMC
T22239 28169-28171 IN denotes in
T22240 28172-28180 NN denotes response
T22241 28181-28183 TO denotes to
T22242 28184-28189 NN denotes IL-15
T22243 28190-28193 CC denotes and
T22244 28194-28199 NN denotes MCP-1
T22245 28200-28202 RB denotes as
T22246 28203-28207 RB denotes well
T22247 28208-28210 IN denotes as
T22248 28211-28222 NN denotes stimulation
T22249 28223-28225 IN denotes by
T22250 28226-28244 JJ denotes anti-CD3/anti-CD28
T22251 28246-28248 PRP denotes We
T22252 28249-28253 VB denotes have
T22253 28254-28258 RB denotes also
T22254 28259-28264 VB denotes shown
T22255 28265-28269 IN denotes that
T22256 28270-28282 NN denotes upregulation
T22257 28283-28285 IN denotes of
T22258 28286-28291 NN denotes IL-17
T22259 28292-28294 IN denotes by
T22260 28295-28304 VB denotes activated
T22261 28305-28306 NN denotes T
T22262 28307-28312 NN denotes cells
T22263 28313-28315 IN denotes in
T22264 28316-28324 NN denotes patients
T22265 28325-28329 IN denotes with
T22266 28330-28332 NN denotes RA
T22267 28333-28338 MD denotes could
T22268 28339-28341 VB denotes be
T22269 28342-28345 DT denotes the
T22270 28346-28352 NN denotes result
T22271 28353-28355 IN denotes of
T22272 28356-28366 NN denotes activation
T22273 28367-28370 IN denotes via
T22274 28371-28374 DT denotes the
T22275 28375-28383 NN denotes PI3K/Akt
T22276 28384-28391 NN denotes pathway
T22277 28392-28396 IN denotes with
T22278 28397-28406 JJ denotes resultant
T22279 28407-28412 NN denotes NF-κB
T22280 28413-28423 NN denotes activation
T22281 28425-28428 PRP-DOLLAR- denotes Our
T22282 28429-28433 NN denotes data
T22283 28434-28441 VB denotes provide
T22284 28442-28450 NN denotes insights
T22285 28451-28455 IN denotes into
T22286 28456-28464 JJ denotes cellular
T22287 28465-28475 NN denotes mechanisms
T22288 28476-28478 IN denotes of
T22289 28479-28482 DT denotes the
T22290 28483-28493 NN denotes regulation
T22291 28494-28496 IN denotes of
T22292 28497-28502 NN denotes IL-17
T22293 28503-28513 NN denotes production
T22294 28514-28516 IN denotes in
T22295 28517-28519 NN denotes RA
T22296 28519-28520 -COMMA- denotes ,
T22297 28521-28524 CC denotes and
T22298 28525-28534 VB denotes highlight
T22299 28535-28538 DT denotes the
T22300 28539-28543 NN denotes role
T22301 28544-28546 IN denotes of
T22302 28547-28548 NN denotes T
T22303 28549-28554 NN denotes cells
T22304 28554-28555 -COMMA- denotes ,
T22305 28556-28561 WDT denotes which
T22306 28562-28565 VB denotes has
T22307 28566-28574 RB denotes hitherto
T22308 28575-28579 VB denotes been
T22309 28580-28589 VB denotes neglected
T22310 28590-28592 IN denotes in
T22311 28593-28595 NN denotes RA
T22312 28596-28608 NN denotes pathogenesis
T22313 28610-28618 RB denotes Together
T22314 28619-28623 IN denotes with
T22315 28624-28630 JJ denotes recent
T22316 28631-28635 NN denotes data
T22317 28636-28638 IN denotes on
T22318 28639-28642 DT denotes the
T22319 28643-28653 JJ denotes successful
T22320 28654-28666 NN denotes introduction
T22321 28667-28669 IN denotes of
T22322 28670-28680 NN denotes anti-IL-17
T22323 28681-28683 IN denotes in
T22324 28684-28686 NN denotes RA
T22325 28686-28687 -COMMA- denotes ,
T22326 28688-28691 PRP-DOLLAR- denotes our
T22327 28692-28699 NN denotes results
T22328 28700-28704 VB denotes have
T22329 28705-28710 VB denotes added
T22330 28711-28722 NN denotes information
T22331 28723-28726 IN denotes for
T22332 28727-28730 DT denotes the
T22333 28731-28737 JJ denotes future
T22334 28738-28747 JJ denotes molecular
T22335 28748-28757 NN denotes targeting
T22336 28758-28760 IN denotes of
T22337 28761-28764 JJ denotes new
T22338 28765-28776 JJ denotes therapeutic
T22339 28777-28789 NN denotes applications
T22340 28790-28792 IN denotes in
T22341 28793-28795 NN denotes RA
R10000 T18977 T18978 arg1Of activation,of
R10001 T18977 T18980 arg1Of activation,in
R10002 T18979 T18978 arg2Of monocytes/macrophages,of
R10003 T18982 T18980 arg2Of cultures,in
R10004 T18982 T18981 arg1Of cultures,PBMC
R10005 T18984 T18983 arg2Of reported,As
R10006 T18984 T18985 arg1Of reported,for
R10007 T18987 T18985 arg2Of individuals,for
R10008 T18987 T18986 arg1Of individuals,normal
R10009 T18987 T18988 arg1Of individuals,[
R10010 T18989 T18988 arg2Of 25,[
R10011 T18990 T18988 arg3Of ],[
R10012 T18994 T18992 arg1Of activation,T
R10013 T18994 T18993 arg1Of activation,cell
R10014 T18994 T18995 arg1Of activation,through
R10015 T18994 T18998 arg1Of activation,increases
R10016 T18996 T18995 arg2Of anti-CD3/anti-CD28,through
R10017 T18998 T18983 arg1Of increases,As
R10018 T18998 T18991 arg1Of increases,","
R10019 T18998 T18997 arg1Of increases,also
R10020 T19000 T18998 arg2Of induction,increases
R10021 T19000 T18999 arg1Of induction,IL-17
R10022 T19000 T19001 arg1Of induction,in
R10023 T19003 T19001 arg2Of PBMC,in
R10024 T19003 T19002 arg1Of PBMC,RA
R10025 T19007 T19005 arg1Of pathway,the
R10026 T19007 T19006 arg1Of pathway,signaling
R10027 T19007 T19008 arg1Of pathway,for
R10028 T19007 T19015 arg1Of pathway,has
R10029 T19007 T19016 arg1Of pathway,been
R10030 T19007 T19017 arg2Of pathway,documented
R10031 T19010 T19008 arg2Of induction,for
R10032 T19010 T19009 arg1Of induction,the
R10033 T19010 T19011 arg1Of induction,of
R10034 T19010 T19013 arg1Of induction,by
R10035 T19012 T19011 arg2Of cytokines/chemokines,of
R10036 T19014 T19013 arg2Of IL-17,by
R10037 T19017 T19004 arg2Of documented,Although
R10038 T19017 T19015 arg2Of documented,has
R10039 T19017 T19016 arg2Of documented,been
R10040 T19017 T19018 arg1Of documented,widely
R10041 T19017 T19019 arg1Of documented,[
R10042 T19020 T19019 arg2Of "8,30,31",[
R10043 T19021 T19019 arg3Of ],[
R10044 T19024 T19023 arg1Of data,no
R10045 T19024 T19025 arg1Of data,have
R10046 T19024 T19026 arg1Of data,been
R10047 T19024 T19027 arg1Of data,available
R10048 T19026 T19004 arg1Of been,Although
R10049 T19026 T19022 arg1Of been,","
R10050 T19026 T19025 arg2Of been,have
R10051 T19027 T19026 arg2Of available,been
R10052 T19027 T19028 arg1Of available,on
R10053 T19029 T19028 arg2Of how,on
R10054 T19031 T19030 arg1Of production,IL-17
R10055 T19031 T19032 arg1Of production,can
R10056 T19031 T19033 arg1Of production,be
R10057 T19031 T19034 arg2Of production,regulated
R10058 T19034 T19029 arg1Of regulated,how
R10059 T19034 T19032 arg2Of regulated,can
R10060 T19034 T19033 arg2Of regulated,be
R10061 T19038 T19034 arg1Of pathways,regulated
R10062 T19038 T19035 arg2Of pathways,by
R10063 T19038 T19036 arg1Of pathways,certain
R10064 T19038 T19037 arg1Of pathways,signaling
R10065 T19040 T19039 arg2Of using,By
R10066 T19043 T19040 arg2Of inhibitors,using
R10067 T19043 T19041 arg1Of inhibitors,signal
R10068 T19043 T19042 arg1Of inhibitors,transduction
R10069 T19045 T19040 arg1Of we,using
R10070 T19045 T19047 arg1Of we,examined
R10071 T19047 T19039 arg1Of examined,By
R10072 T19047 T19044 arg1Of examined,","
R10073 T19047 T19046 arg1Of examined,therefore
R10074 T19048 T19047 arg2Of which,examined
R10075 T19050 T19048 arg1Of pathway,which
R10076 T19050 T19049 arg1Of pathway,signaling
R10077 T19050 T19051 arg1Of pathway,was
R10078 T19050 T19053 arg2Of pathway,involved
R10079 T19053 T19051 arg2Of involved,was
R10080 T19053 T19052 arg1Of involved,mainly
R10081 T19053 T19054 arg1Of involved,in
R10082 T19056 T19054 arg2Of induction,in
R10083 T19056 T19055 arg1Of induction,the
R10084 T19056 T19057 arg1Of induction,of
R10085 T19056 T19059 arg1Of induction,in
R10086 T19058 T19057 arg2Of IL-17,of
R10087 T19061 T19059 arg2Of PBMC,in
R10088 T19061 T19060 arg1Of PBMC,RA
R10089 T19062 T19063 arg1Of We,identified
R10090 T19067 T19065 arg1Of production,anti-CD3-induced
R10091 T19067 T19066 arg1Of production,IL-17
R10092 T19067 T19068 arg1Of production,in
R10093 T19067 T19071 arg1Of production,was
R10094 T19067 T19073 arg2Of production,hampered
R10095 T19070 T19068 arg2Of PBMC,in
R10096 T19070 T19069 arg1Of PBMC,RA
R10097 T19073 T19063 arg2Of hampered,identified
R10098 T19073 T19064 arg1Of hampered,that
R10099 T19073 T19071 arg2Of hampered,was
R10100 T19073 T19072 arg1Of hampered,significantly
R10101 T19077 T19075 arg1Of inhibitor,the
R10102 T19077 T19076 arg1Of inhibitor,PI3K
R10103 T19078 T19077 arg1Of LY294002,inhibitor
R10104 T19078 T19079 arg1Of LY294002,and
R10105 T19079 T19073 arg1Of and,hampered
R10106 T19079 T19074 arg2Of and,by
R10107 T19079 T19084 arg1Of and,to
R10108 T19082 T19080 arg1Of inhibitor,the
R10109 T19082 T19081 arg1Of inhibitor,NF-κB
R10110 T19083 T19079 arg2Of PDTC,and
R10111 T19083 T19082 arg1Of PDTC,inhibitor
R10112 T19086 T19084 arg2Of levels,to
R10113 T19086 T19085 arg1Of levels,comparable
R10114 T19086 T19087 arg1Of levels,of
R10115 T19089 T19087 arg2Of production,of
R10116 T19089 T19088 arg1Of production,basal
R10117 T19089 T19090 arg1Of production,without
R10118 T19091 T19090 arg2Of stimulation,without
R10119 T19092 T19094 arg1Of We,found
R10120 T19094 T19093 arg1Of found,also
R10121 T19098 T19096 arg1Of production,anti-CD3-induced
R10122 T19098 T19097 arg1Of production,IL-17
R10123 T19098 T19099 arg1Of production,was
R10124 T19098 T19100 arg2Of production,downregulated
R10125 T19100 T19094 arg2Of downregulated,found
R10126 T19100 T19095 arg1Of downregulated,that
R10127 T19100 T19099 arg2Of downregulated,was
R10128 T19103 T19100 arg1Of addition,downregulated
R10129 T19103 T19101 arg2Of addition,by
R10130 T19103 T19102 arg1Of addition,the
R10131 T19103 T19104 arg1Of addition,of
R10132 T19105 T19104 arg2Of SB203580,of
R10133 T19105 T19106 arg1Of SB203580,","
R10134 T19110 T19106 arg2Of inhibitor,","
R10135 T19110 T19107 arg1Of inhibitor,a
R10136 T19110 T19108 arg1Of inhibitor,p38
R10137 T19110 T19109 arg1Of inhibitor,MAPK
R10138 T19113 T19112 arg2Of interesting,is
R10139 T19116 T19115 arg1Of series,a
R10140 T19116 T19117 arg1Of series,of
R10141 T19116 T19119 arg1Of series,supports
R10142 T19118 T19117 arg2Of evidence,of
R10143 T19119 T19111 arg1Of supports,It
R10144 T19119 T19112 arg1Of supports,is
R10145 T19119 T19113 arg1Of supports,interesting
R10146 T19119 T19114 arg1Of supports,that
R10147 T19120 T19119 arg2Of crosstalk,supports
R10148 T19120 T19121 arg1Of crosstalk,between
R10149 T19122 T19123 arg1Of NF-κB,and
R10150 T19123 T19121 arg2Of and,between
R10151 T19124 T19123 arg2Of p38,and
R10152 T19126 T19125 arg2Of myocytes,In
R10153 T19129 T19128 arg1Of kinase-β,IκB
R10154 T19129 T19130 arg1Of kinase-β,is
R10155 T19129 T19131 arg2Of kinase-β,activated
R10156 T19131 T19130 arg2Of activated,is
R10157 T19131 T19134 arg1Of activated,[
R10158 T19131 T19138 arg1Of activated,and
R10159 T19133 T19131 arg1Of p38,activated
R10160 T19133 T19132 arg2Of p38,by
R10161 T19135 T19134 arg2Of 32,[
R10162 T19136 T19134 arg3Of ],[
R10163 T19138 T19125 arg1Of and,In
R10164 T19138 T19127 arg1Of and,","
R10165 T19138 T19137 arg1Of and,","
R10166 T19141 T19139 arg1Of p38,the
R10167 T19141 T19140 arg2Of p38,activated
R10168 T19141 T19142 arg1Of p38,can
R10169 T19141 T19143 arg1Of p38,stimulate
R10170 T19143 T19138 arg2Of stimulate,and
R10171 T19143 T19142 arg2Of stimulate,can
R10172 T19143 T19145 arg1Of stimulate,by
R10173 T19144 T19143 arg2Of NF-κB,stimulate
R10174 T19147 T19145 arg2Of mechanism,by
R10175 T19147 T19146 arg1Of mechanism,a
R10176 T19147 T19148 arg1Of mechanism,involving
R10177 T19152 T19148 arg2Of protein,involving
R10178 T19152 T19149 arg1Of protein,histone
R10179 T19152 T19150 arg1Of protein,acetylase
R10180 T19152 T19151 arg1Of protein,p300/CREB-binding
R10181 T19152 T19153 arg1Of protein,[
R10182 T19154 T19153 arg2Of 33,[
R10183 T19155 T19153 arg3Of ],[
R10184 T19157 T19156 arg1Of results,Our
R10185 T19157 T19158 arg1Of results,revealed
R10186 T19162 T19160 arg1Of activation,p38
R10187 T19162 T19161 arg1Of activation,MAPK
R10188 T19162 T19163 arg1Of activation,was
R10189 T19162 T19165 arg2Of activation,affected
R10190 T19165 T19158 arg2Of affected,revealed
R10191 T19165 T19159 arg1Of affected,that
R10192 T19165 T19163 arg2Of affected,was
R10193 T19165 T19164 arg1Of affected,not
R10194 T19165 T19168 arg1Of affected,","
R10195 T19165 T19169 arg1Of affected,whereas
R10196 T19165 T19177 arg1Of affected,","
R10197 T19165 T19178 arg1Of affected,which
R10198 T19165 T19179 arg1Of affected,provided
R10199 T19167 T19165 arg1Of LY294002,affected
R10200 T19167 T19166 arg2Of LY294002,by
R10201 T19172 T19170 arg1Of activity,NF-κB
R10202 T19172 T19171 arg1Of activity,binding
R10203 T19172 T19173 arg1Of activity,was
R10204 T19172 T19174 arg2Of activity,decreased
R10205 T19174 T19169 arg2Of decreased,whereas
R10206 T19174 T19173 arg2Of decreased,was
R10207 T19176 T19174 arg1Of LY294002,decreased
R10208 T19176 T19175 arg2Of LY294002,by
R10209 T19181 T19179 arg2Of evidence,provided
R10210 T19181 T19180 arg1Of evidence,the
R10211 T19181 T19182 arg1Of evidence,for
R10212 T19186 T19182 arg2Of pathway,for
R10213 T19186 T19183 arg1Of pathway,a
R10214 T19186 T19184 arg1Of pathway,p38
R10215 T19186 T19185 arg1Of pathway,MAPK
R10216 T19186 T19187 arg1Of pathway,independent
R10217 T19187 T19188 arg1Of independent,of
R10218 T19190 T19188 arg2Of activation,of
R10219 T19190 T19189 arg1Of activation,PI3K
R10220 T19193 T19191 arg1Of relationship,The
R10221 T19193 T19192 arg1Of relationship,direct
R10222 T19193 T19194 arg1Of relationship,between
R10223 T19193 T19201 arg1Of relationship,needs
R10224 T19193 T19203 arg1Of relationship,be
R10225 T19193 T19204 arg2Of relationship,studied
R10226 T19195 T19196 arg1Of p38,and
R10227 T19196 T19194 arg2Of and,between
R10228 T19196 T19198 arg1Of and,for
R10229 T19197 T19196 arg2Of NF-κB,and
R10230 T19200 T19198 arg2Of production,for
R10231 T19200 T19199 arg1Of production,IL-17
R10232 T19204 T19201 arg2Of studied,needs
R10233 T19204 T19202 arg1Of studied,to
R10234 T19204 T19203 arg2Of studied,be
R10235 T19204 T19205 arg1Of studied,in
R10236 T19207 T19205 arg2Of experiments,in
R10237 T19207 T19206 arg1Of experiments,future
R10238 T19209 T19208 arg1Of search,The
R10239 T19209 T19210 arg1Of search,for
R10240 T19209 T19216 arg1Of search,seemed
R10241 T19209 T19218 arg1Of search,have
R10242 T19213 T19210 arg2Of pathway,for
R10243 T19213 T19211 arg1Of pathway,a
R10244 T19213 T19212 arg1Of pathway,downstream
R10245 T19213 T19214 arg1Of pathway,of
R10246 T19215 T19214 arg2Of PI3K,of
R10247 T19218 T19216 arg2Of have,seemed
R10248 T19218 T19217 arg1Of have,to
R10249 T19218 T19234 arg1Of have,at
R10250 T19221 T19219 arg1Of response,a
R10251 T19221 T19220 arg1Of response,maximal
R10252 T19221 T19222 arg1Of response,of
R10253 T19221 T19225 arg1Of response,at
R10254 T19221 T19228 arg1Of response,and
R10255 T19224 T19222 arg2Of activation,of
R10256 T19224 T19223 arg1Of activation,Akt
R10257 T19227 T19225 arg2Of hour,at
R10258 T19227 T19226 arg1Of hour,1
R10259 T19228 T19218 arg2Of and,have
R10260 T19231 T19228 arg2Of loss,and
R10261 T19231 T19229 arg1Of loss,a
R10262 T19231 T19230 arg1Of loss,gradual
R10263 T19231 T19232 arg1Of loss,of
R10264 T19233 T19232 arg2Of activity,of
R10265 T19236 T19234 arg2Of hours,at
R10266 T19236 T19235 arg1Of hours,2
R10267 T19238 T19237 arg1Of fact,The
R10268 T19238 T19246 arg1Of fact,suggests
R10269 T19240 T19241 arg1Of Akt,is
R10270 T19240 T19242 arg2Of Akt,phosphorylated
R10271 T19242 T19238 arg2Of phosphorylated,fact
R10272 T19242 T19239 arg1Of phosphorylated,that
R10273 T19242 T19241 arg2Of phosphorylated,is
R10274 T19242 T19243 arg1Of phosphorylated,upon
R10275 T19245 T19243 arg2Of stimulation,upon
R10276 T19245 T19244 arg1Of stimulation,anti-CD3
R10277 T19249 T19246 arg2Of involvement,suggests
R10278 T19249 T19247 arg1Of involvement,the
R10279 T19249 T19248 arg1Of involvement,possible
R10280 T19249 T19250 arg1Of involvement,of
R10281 T19249 T19252 arg1Of involvement,in
R10282 T19251 T19250 arg2Of PI3K,of
R10283 T19254 T19252 arg2Of induction,in
R10284 T19254 T19253 arg1Of induction,the
R10285 T19254 T19255 arg1Of induction,of
R10286 T19254 T19257 arg1Of induction,in
R10287 T19256 T19255 arg2Of IL-17,of
R10288 T19258 T19257 arg2Of RA,in
R10289 T19260 T19259 arg2Of view,In
R10290 T19260 T19261 arg1Of view,of
R10291 T19263 T19261 arg2Of fact,of
R10292 T19263 T19262 arg1Of fact,the
R10293 T19265 T19266 arg1Of NF-κB,was
R10294 T19265 T19268 arg2Of NF-κB,activated
R10295 T19268 T19263 arg2Of activated,fact
R10296 T19268 T19264 arg1Of activated,that
R10297 T19268 T19266 arg2Of activated,was
R10298 T19268 T19267 arg1Of activated,also
R10299 T19272 T19273 arg1Of IL-15,or
R10300 T19273 T19268 arg1Of or,activated
R10301 T19273 T19269 arg2Of or,by
R10302 T19273 T19270 arg1Of or,anti-CD3/anti-CD28
R10303 T19273 T19271 arg1Of or,","
R10304 T19273 T19275 arg1Of or,in
R10305 T19274 T19273 arg2Of mitogens,or
R10306 T19277 T19275 arg2Of experiments,in
R10307 T19277 T19276 arg1Of experiments,our
R10308 T19280 T19259 arg1Of is,In
R10309 T19280 T19278 arg1Of is,","
R10310 T19282 T19280 arg2Of likely,is
R10311 T19282 T19281 arg1Of likely,most
R10312 T19286 T19284 arg1Of pathway,the
R10313 T19286 T19285 arg1Of pathway,NF-κB
R10314 T19286 T19287 arg1Of pathway,is
R10315 T19286 T19290 arg2Of pathway,involved
R10316 T19290 T19279 arg1Of involved,it
R10317 T19290 T19280 arg1Of involved,is
R10318 T19290 T19282 arg1Of involved,likely
R10319 T19290 T19283 arg1Of involved,that
R10320 T19290 T19287 arg2Of involved,is
R10321 T19290 T19288 arg1Of involved,also
R10322 T19290 T19289 arg1Of involved,actively
R10323 T19290 T19291 arg1Of involved,in
R10324 T19293 T19291 arg2Of induction,in
R10325 T19293 T19292 arg1Of induction,the
R10326 T19293 T19294 arg1Of induction,of
R10327 T19293 T19296 arg1Of induction,in
R10328 T19295 T19294 arg2Of IL-17,of
R10329 T19298 T19296 arg2Of PBMC,in
R10330 T19298 T19297 arg1Of PBMC,RA
R10331 T19300 T19299 arg2Of contrast,In
R10332 T19306 T19302 arg1Of pathway,the
R10333 T19306 T19303 arg1Of pathway,AP-1
R10334 T19306 T19304 arg1Of pathway,signal
R10335 T19306 T19305 arg1Of pathway,transduction
R10336 T19306 T19307 arg1Of pathway,","
R10337 T19306 T19315 arg1Of pathway,was
R10338 T19306 T19317 arg2Of pathway,activated
R10339 T19311 T19307 arg2Of pathway,","
R10340 T19311 T19308 arg1Of pathway,another
R10341 T19311 T19309 arg1Of pathway,important
R10342 T19311 T19310 arg1Of pathway,signaling
R10343 T19311 T19312 arg1Of pathway,for
R10344 T19313 T19312 arg2Of cytokines/chemokines,for
R10345 T19317 T19299 arg1Of activated,In
R10346 T19317 T19301 arg1Of activated,","
R10347 T19317 T19314 arg1Of activated,","
R10348 T19317 T19315 arg2Of activated,was
R10349 T19317 T19316 arg1Of activated,not
R10350 T19317 T19318 arg1Of activated,in
R10351 T19320 T19318 arg2Of experiments,in
R10352 T19320 T19319 arg1Of experiments,our
R10353 T19320 T19321 arg1Of experiments,(
R10354 T19322 T19321 arg2Of data,(
R10355 T19322 T19324 arg2Of data,shown
R10356 T19324 T19323 arg1Of shown,not
R10357 T19325 T19321 arg3Of ),(
R10358 T19327 T19328 arg1Of PI3K,and
R10359 T19328 T19337 arg1Of and,have
R10360 T19328 T19338 arg1Of and,been
R10361 T19328 T19339 arg2Of and,reported
R10362 T19328 T19341 arg1Of and,deliver
R10363 T19332 T19328 arg2Of Akt,and
R10364 T19332 T19329 arg1Of Akt,its
R10365 T19332 T19330 arg1Of Akt,downstream
R10366 T19332 T19331 arg1Of Akt,kinase
R10367 T19332 T19333 arg1Of Akt,in
R10368 T19334 T19333 arg2Of association,in
R10369 T19334 T19335 arg1Of association,with
R10370 T19336 T19335 arg2Of NF-κB,with
R10371 T19339 T19326 arg2Of reported,Although
R10372 T19339 T19337 arg2Of reported,have
R10373 T19339 T19338 arg2Of reported,been
R10374 T19341 T19339 arg3Of deliver,reported
R10375 T19341 T19340 arg1Of deliver,to
R10376 T19341 T19344 arg1Of deliver,in
R10377 T19343 T19341 arg2Of signals,deliver
R10378 T19343 T19342 arg1Of signals,activating
R10379 T19347 T19344 arg2Of types,in
R10380 T19347 T19345 arg1Of types,many
R10381 T19347 T19346 arg1Of types,cell
R10382 T19350 T19349 arg1Of data,the
R10383 T19350 T19351 arg1Of data,on
R10384 T19350 T19356 arg1Of data,are
R10385 T19350 T19357 arg1Of data,lacking
R10386 T19353 T19351 arg2Of signal,on
R10387 T19353 T19352 arg1Of signal,the
R10388 T19353 T19354 arg1Of signal,inducing
R10389 T19355 T19354 arg2Of IL-17,inducing
R10390 T19357 T19326 arg1Of lacking,Although
R10391 T19357 T19348 arg1Of lacking,","
R10392 T19357 T19356 arg2Of lacking,are
R10393 T19359 T19358 arg1Of data,Our
R10394 T19359 T19361 arg1Of data,demonstrated
R10395 T19361 T19360 arg1Of demonstrated,clearly
R10396 T19363 T19364 arg1Of PI3K/Akt,and
R10397 T19364 T19368 arg1Of and,could
R10398 T19364 T19369 arg1Of and,be
R10399 T19367 T19364 arg2Of activation,and
R10400 T19367 T19365 arg1Of activation,resultant
R10401 T19367 T19366 arg1Of activation,NF-κB
R10402 T19369 T19361 arg2Of be,demonstrated
R10403 T19369 T19362 arg1Of be,that
R10404 T19369 T19368 arg2Of be,could
R10405 T19372 T19369 arg2Of arbitrator,be
R10406 T19372 T19370 arg1Of arbitrator,an
R10407 T19372 T19371 arg1Of arbitrator,important
R10408 T19372 T19373 arg1Of arbitrator,of
R10409 T19372 T19380 arg1Of arbitrator,","
R10410 T19372 T19381 arg1Of arbitrator,on
R10411 T19375 T19373 arg2Of upregulation,of
R10412 T19375 T19374 arg1Of upregulation,the
R10413 T19375 T19376 arg1Of upregulation,of
R10414 T19375 T19378 arg1Of upregulation,in
R10415 T19377 T19376 arg2Of IL-17,of
R10416 T19379 T19378 arg2Of RA,in
R10417 T19383 T19381 arg2Of basis,on
R10418 T19383 T19382 arg1Of basis,the
R10419 T19383 T19384 arg1Of basis,of
R10420 T19383 T19387 arg1Of basis,showing
R10421 T19386 T19384 arg2Of experiments,of
R10422 T19386 T19385 arg1Of experiments,our
R10423 T19389 T19387 arg2Of blocking,showing
R10424 T19389 T19388 arg1Of blocking,simultaneous
R10425 T19389 T19390 arg1Of blocking,of
R10426 T19389 T19394 arg1Of blocking,in
R10427 T19389 T19398 arg1Of blocking,by
R10428 T19393 T19390 arg2Of activity,of
R10429 T19393 T19391 arg1Of activity,NF-κB
R10430 T19393 T19392 arg1Of activity,binding
R10431 T19397 T19394 arg2Of promoter,in
R10432 T19397 T19395 arg1Of promoter,the
R10433 T19397 T19396 arg1Of promoter,IL-17
R10434 T19399 T19400 arg1Of PDTC,and
R10435 T19400 T19398 arg2Of and,by
R10436 T19401 T19400 arg2Of LY294002,and
R10437 T19402 T19406 arg1Of Considering,and
R10438 T19405 T19402 arg2Of activities,Considering
R10439 T19405 T19403 arg1Of activities,its
R10440 T19405 T19404 arg1Of activities,proinflammatory
R10441 T19406 T19426 arg1Of and,is
R10442 T19408 T19406 arg2Of induction,and
R10443 T19408 T19407 arg1Of induction,successful
R10444 T19408 T19409 arg1Of induction,of
R10445 T19408 T19411 arg1Of induction,for
R10446 T19410 T19409 arg2Of anti-IL-17,of
R10447 T19412 T19411 arg2Of ameliorating,for
R10448 T19412 T19414 arg1Of ameliorating,in
R10449 T19412 T19420 arg1Of ameliorating,","
R10450 T19412 T19421 modOf ameliorating,understanding
R10451 T19413 T19412 arg2Of arthritis,ameliorating
R10452 T19416 T19414 arg2Of models,in
R10453 T19416 T19415 arg1Of models,animal
R10454 T19416 T19417 arg1Of models,[
R10455 T19418 T19417 arg2Of "2,6,34-36",[
R10456 T19419 T19417 arg3Of ],[
R10457 T19425 T19421 arg2Of pathway,understanding
R10458 T19425 T19422 arg1Of pathway,the
R10459 T19425 T19423 arg1Of pathway,IL-17
R10460 T19425 T19424 arg1Of pathway,signaling
R10461 T19429 T19426 arg2Of element,is
R10462 T19429 T19427 arg1Of element,an
R10463 T19429 T19428 arg1Of element,important
R10464 T19429 T19430 arg1Of element,of
R10465 T19431 T19430 arg2Of developing,of
R10466 T19434 T19431 arg2Of therapies,developing
R10467 T19434 T19432 arg1Of therapies,new
R10468 T19434 T19433 arg2Of therapies,targeted
R10469 T19434 T19435 arg1Of therapies,in
R10470 T19436 T19435 arg2Of RA,in
R108 T666 T664 arg2Of production,Increased
R109 T666 T665 arg1Of production,interleukin-17
R110 T666 T667 arg1Of production,via
R111 T666 T671 arg1Of production,and
R112 T670 T667 arg2Of 3-kinase/Akt,via
R113 T670 T668 arg1Of 3-kinase/Akt,a
R114 T670 T669 arg1Of 3-kinase/Akt,phosphoinositide
R115 T671 T676 arg1Of and,ay
R1151 T2894 T2893 arg1Of arthritis,Rheumatoid
R1152 T2894 T2895 arg1Of arthritis,(
R1153 T2894 T2898 arg1Of arthritis,is
R1154 T2894 T2899 arg2Of arthritis,characterized
R1155 T2896 T2895 arg2Of RA,(
R1156 T2897 T2895 arg3Of ),(
R1157 T2899 T2898 arg2Of characterized,is
R1158 T2901 T2899 arg1Of infiltrations,characterized
R1159 T2901 T2900 arg2Of infiltrations,by
R116 T675 T671 arg2Of t pathw,and
R1160 T2901 T2902 arg1Of infiltrations,of
R1161 T2903 T2904 arg1Of macrophages,and
R1162 T2904 T2907 arg1Of and,into
R1163 T2904 T2911 arg1Of and,and
R1164 T2906 T2904 arg2Of cells,and
R1165 T2906 T2905 arg1Of cells,T
R1166 T2909 T2907 arg2Of joint,into
R1167 T2909 T2908 arg1Of joint,the
R1168 T2911 T2902 arg2Of and,of
R1169 T2911 T2910 arg1Of and,","
R117 T675 T672 arg1Of t pathw,nuclear
R1170 T2913 T2911 arg2Of hyperplasia,and
R1171 T2913 T2912 arg1Of hyperplasia,synovial
R1172 T2915 T2914 arg1Of cytokines,Proinflammatory
R1173 T2915 T2916 arg2Of cytokines,released
R1174 T2915 T2920 arg1Of cytokines,are
R1175 T2915 T2921 arg2Of cytokines,known
R1176 T2915 T2923 arg1Of cytokines,be
R1177 T2915 T2924 arg1Of cytokines,important
R1178 T2916 T2917 arg1Of released,from
R1179 T2919 T2917 arg2Of cells,from
R118 T675 T673 arg1Of t pathw,factor
R1180 T2919 T2918 arg1Of cells,these
R1181 T2921 T2920 arg2Of known,are
R1182 T2921 T2932 arg1Of known,[
R1183 T2923 T2921 arg3Of be,known
R1184 T2923 T2922 arg1Of be,to
R1185 T2924 T2923 arg2Of important,be
R1186 T2924 T2925 arg1Of important,in
R1187 T2927 T2925 arg2Of destruction,in
R1188 T2927 T2926 arg1Of destruction,the
R1189 T2927 T2928 arg1Of destruction,of
R119 T675 T674 arg1Of t pathw,κB-dependen
R1190 T2927 T2930 arg1Of destruction,in
R1191 T2929 T2928 arg2Of joints,of
R1192 T2931 T2930 arg2Of RA,in
R1193 T2933 T2932 arg2Of 1,[
R1194 T2934 T2932 arg3Of ],[
R1195 T2938 T2935 arg1Of benefits,The
R1196 T2938 T2936 arg1Of benefits,favorable
R1197 T2938 T2937 arg1Of benefits,clinical
R1198 T2938 T2939 arg2Of benefits,obtained
R1199 T2938 T2950 arg1Of benefits,)
R120 T677 T676 arg2Of in patie,ay
R1200 T2938 T2951 arg1Of benefits,and
R1201 T2939 T2940 arg1Of obtained,with
R1202 T2941 T2940 arg2Of inhibitors,with
R1203 T2941 T2942 arg1Of inhibitors,of
R1204 T2945 T2943 arg1Of factor,tumor
R1205 T2945 T2944 arg1Of factor,necrosis
R1206 T2945 T2946 arg1Of factor,(
R1207 T2947 T2946 arg2Of TNF,(
R12078 T22227 T22228 arg1Of We,have
R12079 T22227 T22229 arg1Of We,detected
R1208 T2948 T2946 arg3Of ),(
R12080 T22229 T22228 arg2Of detected,have
R12081 T22229 T22239 arg1Of detected,in
R12082 T22232 T22231 arg1Of pronounced,more
R12083 T22233 T22229 arg2Of production,detected
R12084 T22233 T22230 arg1Of production,a
R12085 T22233 T22232 arg1Of production,pronounced
R12086 T22233 T22234 arg1Of production,of
R12087 T22233 T22236 arg1Of production,from
R12088 T22235 T22234 arg2Of IL-17,of
R12089 T22238 T22236 arg2Of PBMC,from
R1209 T2949 T2942 arg2Of -α,of
R12090 T22238 T22237 arg1Of PBMC,RA
R12091 T22240 T22239 arg2Of response,in
R12092 T22240 T22241 arg1Of response,to
R12093 T22242 T22243 arg1Of IL-15,and
R12094 T22243 T22247 arg1Of and,as
R12095 T22244 T22243 arg2Of MCP-1,and
R12096 T22247 T22241 arg2Of as,to
R12097 T22247 T22245 arg1Of as,as
R12098 T22247 T22246 arg1Of as,well
R12099 T22248 T22247 arg2Of stimulation,as
R121 T677 T678 arg1Of in patie,nts
R1210 T2949 T2945 arg1Of -α,factor
R12100 T22248 T22249 arg1Of stimulation,by
R12101 T22250 T22249 arg2Of anti-CD3/anti-CD28,by
R12102 T22251 T22252 arg1Of We,have
R12103 T22251 T22254 arg1Of We,shown
R12104 T22254 T22252 arg2Of shown,have
R12105 T22254 T22253 arg1Of shown,also
R12106 T22256 T22257 arg1Of upregulation,of
R12107 T22256 T22259 arg1Of upregulation,by
R12108 T22256 T22263 arg1Of upregulation,in
R12109 T22256 T22267 arg1Of upregulation,could
R1211 T2951 T2957 arg1Of and,suggest
R12110 T22256 T22268 arg1Of upregulation,be
R12111 T22258 T22257 arg2Of IL-17,of
R12112 T22262 T22259 arg2Of cells,by
R12113 T22262 T22260 arg2Of cells,activated
R12114 T22262 T22261 arg1Of cells,T
R12115 T22264 T22263 arg2Of patients,in
R12116 T22264 T22265 arg1Of patients,with
R12117 T22266 T22265 arg2Of RA,with
R12118 T22268 T22254 arg2Of be,shown
R12119 T22268 T22255 arg1Of be,that
R1212 T2952 T2951 arg2Of interleukin,and
R12120 T22268 T22267 arg2Of be,could
R12121 T22270 T22268 arg2Of result,be
R12122 T22270 T22269 arg1Of result,the
R12123 T22270 T22271 arg1Of result,of
R12124 T22270 T22273 arg1Of result,via
R12125 T22272 T22271 arg2Of activation,of
R12126 T22276 T22273 arg2Of pathway,via
R12127 T22276 T22274 arg1Of pathway,the
R12128 T22276 T22275 arg1Of pathway,PI3K/Akt
R12129 T22276 T22277 arg1Of pathway,with
R1213 T2952 T2953 arg1Of interleukin,(
R12130 T22280 T22277 arg2Of activation,with
R12131 T22280 T22278 arg1Of activation,resultant
R12132 T22280 T22279 arg1Of activation,NF-κB
R12133 T22282 T22281 arg1Of data,Our
R12134 T22282 T22283 arg1Of data,provide
R12135 T22282 T22298 arg1Of data,highlight
R12136 T22283 T22285 arg1Of provide,into
R12137 T22283 T22297 arg1Of provide,and
R12138 T22284 T22283 arg2Of insights,provide
R12139 T22287 T22285 arg2Of mechanisms,into
R1214 T2952 T2956 arg1Of interleukin,-1
R12140 T22287 T22286 arg1Of mechanisms,cellular
R12141 T22287 T22288 arg1Of mechanisms,of
R12142 T22290 T22288 arg2Of regulation,of
R12143 T22290 T22289 arg1Of regulation,the
R12144 T22290 T22291 arg1Of regulation,of
R12145 T22293 T22291 arg2Of production,of
R12146 T22293 T22292 arg1Of production,IL-17
R12147 T22293 T22294 arg1Of production,in
R12148 T22295 T22294 arg2Of RA,in
R12149 T22297 T22296 arg1Of and,","
R1215 T2954 T2953 arg2Of IL,(
R12150 T22298 T22297 arg2Of highlight,and
R12151 T22300 T22298 arg2Of role,highlight
R12152 T22300 T22299 arg1Of role,the
R12153 T22300 T22301 arg1Of role,of
R12154 T22300 T22304 arg1Of role,","
R12155 T22300 T22305 arg1Of role,which
R12156 T22300 T22306 arg1Of role,has
R12157 T22300 T22308 arg1Of role,been
R12158 T22300 T22309 arg2Of role,neglected
R12159 T22303 T22301 arg2Of cells,of
R1216 T2955 T2953 arg3Of ),(
R12160 T22303 T22302 arg1Of cells,T
R12161 T22309 T22306 arg2Of neglected,has
R12162 T22309 T22307 arg1Of neglected,hitherto
R12163 T22309 T22308 arg2Of neglected,been
R12164 T22309 T22310 arg1Of neglected,in
R12165 T22312 T22310 arg2Of pathogenesis,in
R12166 T22312 T22311 arg1Of pathogenesis,RA
R12167 T22316 T22314 arg2Of data,with
R12168 T22316 T22315 arg1Of data,recent
R12169 T22316 T22317 arg1Of data,on
R1217 T2960 T2959 arg1Of blockade,the
R12170 T22320 T22317 arg2Of introduction,on
R12171 T22320 T22318 arg1Of introduction,the
R12172 T22320 T22319 arg1Of introduction,successful
R12173 T22320 T22321 arg1Of introduction,of
R12174 T22320 T22323 arg1Of introduction,in
R12175 T22322 T22321 arg2Of anti-IL-17,of
R12176 T22324 T22323 arg2Of RA,in
R12177 T22327 T22326 arg1Of results,our
R12178 T22327 T22328 arg1Of results,have
R12179 T22327 T22329 arg1Of results,added
R1218 T2960 T2961 arg1Of blockade,of
R12180 T22329 T22313 arg1Of added,Together
R12181 T22329 T22314 arg1Of added,with
R12182 T22329 T22325 arg1Of added,","
R12183 T22329 T22328 arg2Of added,have
R12184 T22330 T22329 arg2Of information,added
R12185 T22330 T22331 arg1Of information,for
R12186 T22335 T22331 arg2Of targeting,for
R12187 T22335 T22332 arg1Of targeting,the
R12188 T22335 T22333 arg1Of targeting,future
R12189 T22335 T22334 arg1Of targeting,molecular
R1219 T2960 T2965 arg1Of blockade,has
R12190 T22335 T22336 arg1Of targeting,of
R12191 T22338 T22337 arg1Of therapeutic,new
R12192 T22339 T22336 arg2Of applications,of
R12193 T22339 T22338 arg1Of applications,therapeutic
R12194 T22339 T22340 arg1Of applications,in
R12195 T22341 T22340 arg2Of RA,in
R122 T680 T678 arg2Of atoid art,nts
R1220 T2960 T2966 arg1Of blockade,been
R1221 T2964 T2961 arg2Of cytokines,of
R1222 T2964 T2962 arg1Of cytokines,key
R1223 T2964 T2963 arg1Of cytokines,inflammatory
R1224 T2966 T2957 arg2Of been,suggest
R1225 T2966 T2958 arg1Of been,that
R1226 T2966 T2965 arg2Of been,has
R1227 T2966 T2970 arg1Of been,in
R1228 T2966 T2977 arg1Of been,[
R1229 T2969 T2966 arg2Of issue,been
R123 T680 T679 arg1Of atoid art,with rheum
R1230 T2969 T2967 arg1Of issue,the
R1231 T2969 T2968 arg1Of issue,important
R1232 T2972 T2970 arg2Of development,in
R1233 T2972 T2971 arg1Of development,the
R1234 T2972 T2973 arg1Of development,of
R1235 T2976 T2973 arg2Of applications,of
R1236 T2976 T2974 arg1Of applications,new
R1237 T2976 T2975 arg1Of applications,therapeutic
R1238 T2978 T2977 arg2Of 2,[
R1239 T2979 T2977 arg3Of ],[
R124 T682 T681 arg1Of mediators,Inflammatory
R1240 T2981 T2980 arg1Of little,A
R1241 T2983 T2982 arg1Of a,over
R1242 T2984 T2983 arg1Of decade,a
R1243 T2985 T2981 arg1Of ago,little
R1244 T2985 T2984 arg1Of ago,decade
R1245 T2988 T2987 arg1Of primacy,the
R1246 T2988 T2989 arg1Of primacy,of
R1247 T2988 T2992 arg1Of primacy,in
R1248 T2988 T2999 arg1Of primacy,as
R1249 T2988 T3001 arg1Of primacy,was
R125 T682 T683 arg1Of mediators,have
R1250 T2988 T3002 arg1Of primacy,undisputed
R1251 T2991 T2989 arg2Of cells,of
R1252 T2991 T2990 arg1Of cells,T
R1253 T2994 T2992 arg2Of pathogenesis,in
R1254 T2994 T2993 arg1Of pathogenesis,the
R1255 T2994 T2995 arg1Of pathogenesis,of
R1256 T2997 T2995 arg2Of disease,of
R1257 T2997 T2996 arg1Of disease,autoimmune
R1258 T2999 T2998 arg1Of as,such
R1259 T3000 T2999 arg2Of RA,as
R126 T682 T684 arg1Of mediators,been
R1260 T3001 T2985 arg1Of was,ago
R1261 T3001 T2986 arg1Of was,","
R1262 T3001 T3003 arg1Of was,because
R1263 T3002 T3001 arg2Of undisputed,was
R1264 T3004 T3005 arg1Of they,are
R1265 T3005 T3003 arg2Of are,because
R1266 T3009 T3005 arg2Of population,are
R1267 T3009 T3006 arg1Of population,the
R1268 T3009 T3007 arg1Of population,largest
R1269 T3009 T3008 arg1Of population,cell
R127 T682 T685 arg2Of mediators,recognized
R1270 T3009 T3010 arg1Of population,infiltrating
R1271 T3012 T3010 arg2Of synovium,infiltrating
R1272 T3012 T3011 arg1Of synovium,the
R1273 T3016 T3015 arg1Of series,a
R1274 T3016 T3017 arg1Of series,of
R1275 T3016 T3019 arg1Of series,demonstrated
R1276 T3018 T3017 arg2Of studies,of
R1277 T3019 T3013 arg1Of demonstrated,However
R1278 T3019 T3014 arg1Of demonstrated,","
R1279 T3019 T3035 arg1Of demonstrated,","
R128 T685 T683 arg2Of recognized,have
R1280 T3019 T3036 arg1Of demonstrated,whereas
R1281 T3020 T3019 arg2Of paucity,demonstrated
R1282 T3020 T3021 arg1Of paucity,of
R1283 T3024 T3021 arg2Of cytokines,of
R1284 T3024 T3022 arg1Of cytokines,T
R1285 T3024 T3023 arg1Of cytokines,cell-derived
R1286 T3024 T3026 arg1Of cytokines,as
R1287 T3026 T3025 arg1Of as,such
R1288 T3027 T3028 arg1Of IL-2,and
R1289 T3028 T3026 arg2Of and,as
R129 T685 T684 arg2Of recognized,been
R1290 T3028 T3030 arg1Of and,in
R1291 T3029 T3028 arg2Of interferon-γ,and
R1292 T3032 T3030 arg2Of joints,in
R1293 T3032 T3031 arg1Of joints,the
R1294 T3032 T3033 arg1Of joints,of
R1295 T3034 T3033 arg2Of RA,of
R1296 T3037 T3038 arg1Of macrophage,and
R1297 T3039 T3038 arg2Of fibroblast,and
R1298 T3040 T3037 arg1Of cytokines,macrophage
R1299 T3040 T3039 arg1Of cytokines,fibroblast
R130 T685 T686 arg1Of recognized,as
R1300 T3040 T3041 arg1Of cytokines,including
R1301 T3040 T3051 arg1Of cytokines,were
R1302 T3040 T3052 arg1Of cytokines,abundant
R1303 T3042 T3043 arg1Of IL-1,","
R1304 T3043 T3045 arg1Of ",",","
R1305 T3044 T3043 arg2Of IL-6,","
R1306 T3045 T3047 arg1Of ",",","
R1307 T3046 T3045 arg2Of IL-15,","
R1308 T3047 T3049 arg1Of ",",and
R1309 T3048 T3047 arg2Of IL-18,","
R131 T687 T686 arg2Of being,as
R1310 T3049 T3041 arg2Of and,including
R1311 T3050 T3049 arg2Of TNF-α,and
R1312 T3051 T3036 arg2Of were,whereas
R1313 T3051 T3053 arg1Of were,in
R1314 T3052 T3051 arg2Of abundant,were
R1315 T3055 T3053 arg2Of synovium,in
R1316 T3055 T3054 arg1Of synovium,rheumatoid
R1317 T3057 T3056 arg1Of paradox,This
R1318 T3057 T3058 arg1Of paradox,has
R1319 T3057 T3059 arg1Of paradox,questioned
R132 T687 T689 arg1Of being,in
R1320 T3059 T3058 arg2Of questioned,has
R1321 T3061 T3059 arg2Of role,questioned
R1322 T3061 T3060 arg1Of role,the
R1323 T3061 T3062 arg1Of role,of
R1324 T3061 T3065 arg1Of role,in
R1325 T3064 T3062 arg2Of cells,of
R1326 T3064 T3063 arg1Of cells,T
R1327 T3067 T3065 arg2Of pathogenesis,in
R1328 T3067 T3066 arg1Of pathogenesis,the
R1329 T3067 T3068 arg1Of pathogenesis,of
R133 T688 T687 arg2Of important,being
R1330 T3069 T3068 arg2Of RA,of
R1331 T3069 T3070 arg1Of RA,[
R1332 T3071 T3070 arg2Of 3,[
R1333 T3072 T3070 arg3Of ],[
R1334 T3074 T3075 arg1Of we,have
R1335 T3074 T3077 arg1Of we,demonstrated
R1336 T3077 T3073 arg2Of demonstrated,Because
R1337 T3077 T3075 arg2Of demonstrated,have
R1338 T3077 T3076 arg1Of demonstrated,already
R1339 T3077 T3105 arg1Of demonstrated,in
R134 T691 T689 arg2Of pathogenesis,in
R1340 T3080 T3078 arg1Of proliferation,the
R1341 T3080 T3079 arg2Of proliferation,enhanced
R1342 T3080 T3081 arg1Of proliferation,of
R1343 T3080 T3086 arg1Of proliferation,","
R1344 T3080 T3088 arg1Of proliferation,to
R1345 T3080 T3093 arg1Of proliferation,and
R1346 T3085 T3081 arg2Of cells,of
R1347 T3085 T3082 arg1Of cells,antigen
R1348 T3085 T3083 arg1Of cells,specific
R1349 T3085 T3084 arg1Of cells,T
R135 T691 T690 arg1Of pathogenesis,the
R1350 T3088 T3087 arg1Of to,especially
R1351 T3091 T3088 arg2Of collagen,to
R1352 T3091 T3089 arg1Of collagen,type
R1353 T3091 T3090 arg1Of collagen,II
R1354 T3093 T3077 arg2Of and,demonstrated
R1355 T3093 T3092 arg1Of and,","
R1356 T3095 T3093 arg2Of skewing,and
R1357 T3095 T3094 arg1Of skewing,the
R1358 T3095 T3096 arg1Of skewing,of
R1359 T3102 T3101 arg2Of Th1,(
R136 T691 T692 arg1Of pathogenesis,of
R1360 T3103 T3101 arg3Of ),(
R1361 T3104 T3096 arg2Of cytokines,of
R1362 T3104 T3097 arg1Of cytokines,T
R1363 T3104 T3098 arg1Of cytokines,helper
R1364 T3104 T3099 arg1Of cytokines,type
R1365 T3104 T3100 arg1Of cytokines,1
R1366 T3104 T3101 arg1Of cytokines,(
R1367 T3106 T3105 arg2Of RA,in
R1368 T3106 T3107 arg1Of RA,[
R1369 T3108 T3107 arg2Of 4,[
R137 T694 T692 arg2Of arthritis,of
R1370 T3109 T3107 arg3Of ],[
R1371 T3112 T3111 arg1Of role,the
R1372 T3112 T3113 arg1Of role,of
R1373 T3112 T3116 arg1Of role,needs
R1374 T3112 T3118 arg1Of role,be
R1375 T3112 T3119 arg2Of role,elucidated
R1376 T3115 T3113 arg2Of cells,of
R1377 T3115 T3114 arg1Of cells,T
R1378 T3116 T3073 arg1Of needs,Because
R1379 T3116 T3110 arg1Of needs,","
R138 T694 T693 arg1Of arthritis,rheumatoid
R1380 T3119 T3116 arg2Of elucidated,needs
R1381 T3119 T3117 arg1Of elucidated,to
R1382 T3119 T3118 arg2Of elucidated,be
R1383 T3119 T3120 arg1Of elucidated,in
R1384 T3122 T3120 arg2Of aspects,in
R1385 T3122 T3121 arg1Of aspects,different
R1386 T3123 T3124 arg1Of IL-17,is
R1387 T3125 T3124 arg2Of one,is
R1388 T3125 T3126 arg1Of one,of
R1389 T3129 T3126 arg2Of cytokines,of
R139 T694 T695 arg1Of arthritis,(
R1390 T3129 T3127 arg1Of cytokines,the
R1391 T3129 T3128 arg1Of cytokines,inflammatory
R1392 T3129 T3130 arg2Of cytokines,secreted
R1393 T3135 T3130 arg1Of cells,secreted
R1394 T3135 T3131 arg1Of cells,mainly
R1395 T3135 T3132 arg2Of cells,by
R1396 T3135 T3133 arg2Of cells,activated
R1397 T3135 T3134 arg1Of cells,T
R1398 T3135 T3136 arg1Of cells,","
R1399 T3135 T3137 arg1Of cells,which
R140 T696 T695 arg2Of RA,(
R1400 T3135 T3138 arg1Of cells,can
R1401 T3135 T3139 arg1Of cells,induce
R1402 T3139 T3138 arg2Of induce,can
R1403 T3139 T3145 arg1Of induce,[
R1404 T3140 T3141 arg1Of IL-6,and
R1405 T3141 T3139 arg2Of and,induce
R1406 T3141 T3143 arg1Of and,by
R1407 T3142 T3141 arg2Of IL-8,and
R1408 T3144 T3143 arg2Of fibroblasts,by
R1409 T3146 T3145 arg2Of 5,[
R141 T697 T695 arg3Of ),(
R1410 T3147 T3145 arg3Of ],[
R1411 T3149 T3148 arg1Of cytokine,This
R1412 T3149 T3150 arg1Of cytokine,is
R1413 T3149 T3151 arg1Of cytokine,of
R1414 T3150 T3153 arg1Of is,for
R1415 T3150 T3157 arg1Of is,:
R1416 T3151 T3150 arg2Of of,is
R1417 T3152 T3151 arg2Of interest,of
R1418 T3156 T3153 arg2Of reasons,for
R1419 T3156 T3154 arg1Of reasons,two
R142 T698 T699 arg1Of Interleukin,(
R1420 T3156 T3155 arg1Of reasons,major
R1421 T3158 T3159 arg1Of first,","
R1422 T3160 T3159 arg2Of similarly,","
R1423 T3160 T3161 arg1Of similarly,to
R1424 T3162 T3163 arg1Of TNF-α,and
R1425 T3163 T3161 arg2Of and,to
R1426 T3164 T3163 arg2Of IL-1,and
R1427 T3166 T3167 arg1Of IL-17,has
R1428 T3167 T3157 arg2Of has,:
R1429 T3167 T3158 arg1Of has,first
R143 T698 T702 arg1Of Interleukin,-17
R1430 T3167 T3160 arg1Of has,similarly
R1431 T3167 T3165 arg1Of has,","
R1432 T3167 T3170 arg1Of has,;
R1433 T3169 T3167 arg2Of properties,has
R1434 T3169 T3168 arg1Of properties,proinflammatory
R1435 T3173 T3174 arg1Of it,is
R1436 T3173 T3175 arg2Of it,produced
R1437 T3175 T3170 arg2Of produced,;
R1438 T3175 T3171 arg1Of produced,second
R1439 T3175 T3172 arg1Of produced,","
R144 T698 T703 arg1Of Interleukin,is
R1440 T3175 T3174 arg2Of produced,is
R1441 T3175 T3179 arg1Of produced,[
R1442 T3178 T3175 arg1Of cells,produced
R1443 T3178 T3176 arg2Of cells,by
R1444 T3178 T3177 arg1Of cells,T
R1445 T3180 T3179 arg2Of 6,[
R1446 T3181 T3179 arg3Of ],[
R1447 T3183 T3182 arg1Of observations,Recent
R1448 T3183 T3184 arg1Of observations,demonstrated
R1449 T3186 T3187 arg1Of IL-17,can
R145 T700 T699 arg2Of IL,(
R1450 T3186 T3189 arg1Of IL-17,activate
R1451 T3189 T3184 arg2Of activate,demonstrated
R1452 T3189 T3185 arg1Of activate,that
R1453 T3189 T3187 arg2Of activate,can
R1454 T3189 T3188 arg1Of activate,also
R1455 T3189 T3193 arg1Of activate,by
R1456 T3192 T3189 arg2Of resorption,activate
R1457 T3192 T3190 arg1Of resorption,osteoclastic
R1458 T3192 T3191 arg1Of resorption,bone
R1459 T3195 T3193 arg2Of induction,by
R146 T701 T699 arg3Of ),(
R1460 T3195 T3194 arg1Of induction,the
R1461 T3195 T3196 arg1Of induction,of
R1462 T3195 T3198 arg1Of induction,(
R1463 T3195 T3210 arg1Of induction,","
R1464 T3195 T3211 arg1Of induction,which
R1465 T3195 T3212 arg1Of induction,is
R1466 T3195 T3213 arg2Of induction,involved
R1467 T3197 T3196 arg2Of RANKL,of
R1468 T3200 T3198 arg2Of activator,(
R1469 T3200 T3199 arg1Of activator,receptor
R147 T706 T703 arg2Of regulator,is
R1470 T3200 T3201 arg1Of activator,of
R1471 T3206 T3205 arg2Of NF-κB,[
R1472 T3207 T3205 arg3Of ],[
R1473 T3208 T3201 arg2Of ligand,of
R1474 T3208 T3202 arg1Of ligand,nuclear
R1475 T3208 T3203 arg1Of ligand,factor
R1476 T3208 T3204 arg1Of ligand,κB
R1477 T3208 T3205 arg1Of ligand,[
R1478 T3209 T3198 arg3Of ),(
R1479 T3213 T3212 arg2Of involved,is
R148 T706 T704 arg1Of regulator,an
R1480 T3213 T3214 arg1Of involved,in
R1481 T3216 T3214 arg2Of erosion,in
R1482 T3216 T3215 arg1Of erosion,bony
R1483 T3216 T3217 arg1Of erosion,in
R1484 T3218 T3217 arg2Of RA,in
R1485 T3218 T3219 arg1Of RA,[
R1486 T3220 T3219 arg2Of 7,[
R1487 T3221 T3219 arg3Of ],[
R1488 T3222 T3224 arg1Of It,stimulates
R1489 T3222 T3247 arg1Of It,has
R149 T706 T705 arg1Of regulator,important
R1490 T3224 T3246 arg1Of stimulates,and
R1491 T3226 T3224 arg2Of production,stimulates
R1492 T3226 T3225 arg1Of production,the
R1493 T3226 T3227 arg1Of production,of
R1494 T3226 T3237 arg1Of production,of
R1495 T3227 T3236 arg1Of of,and
R1496 T3228 T3229 arg1Of IL-6,and
R1497 T3229 T3227 arg2Of and,of
R1498 T3229 T3233 arg1Of and,by
R1499 T3232 T3229 arg2Of factor,and
R150 T706 T707 arg1Of regulator,of
R1500 T3232 T3230 arg1Of factor,leukemia
R1501 T3232 T3231 arg1Of factor,inhibitory
R1502 T3234 T3233 arg2Of synoviocytes,by
R1503 T3236 T3235 arg1Of and,","
R1504 T3237 T3236 arg2Of of,and
R1505 T3239 T3238 arg1Of E2,prostaglandin
R1506 T3239 T3240 arg1Of E2,and
R1507 T3240 T3237 arg2Of and,of
R1508 T3240 T3243 arg1Of and,by
R1509 T3242 T3240 arg2Of oxide,and
R151 T708 T709 arg1Of immune,and
R1510 T3242 T3241 arg1Of oxide,nitric
R1511 T3244 T3243 arg2Of chondrocytes,by
R1512 T3246 T3223 arg1Of and,also
R1513 T3246 T3245 arg1Of and,","
R1514 T3247 T3246 arg2Of has,and
R1515 T3249 T3247 arg2Of ability,has
R1516 T3249 T3248 arg1Of ability,the
R1517 T3249 T3250 modOf ability,to
R1518 T3251 T3252 arg1Of differentiate,and
R1519 T3252 T3250 arg1Of and,to
R152 T710 T709 arg2Of inflammatory,and
R1520 T3252 T3257 arg1Of and,[
R1521 T3253 T3252 arg2Of activate,and
R1522 T3256 T3251 arg2Of cells,differentiate
R1523 T3256 T3253 arg2Of cells,activate
R1524 T3256 T3254 arg1Of cells,the
R1525 T3256 T3255 arg1Of cells,dendritic
R1526 T3258 T3257 arg2Of 8-10,[
R1527 T3259 T3257 arg3Of ],[
R1528 T3260 T3261 arg1Of Levels,of
R1529 T3260 T3263 arg1Of Levels,in
R153 T711 T707 arg2Of responses,of
R1530 T3260 T3266 arg1Of Levels,were
R1531 T3260 T3268 arg1Of Levels,higher
R1532 T3262 T3261 arg2Of IL-17,of
R1533 T3265 T3263 arg2Of fluids,in
R1534 T3265 T3264 arg1Of fluids,synovial
R1535 T3266 T3282 arg1Of were,and
R1536 T3268 T3266 arg2Of higher,were
R1537 T3268 T3267 arg1Of higher,significantly
R1538 T3268 T3269 arg1Of higher,in
R1539 T3268 T3273 arg1Of higher,than
R154 T711 T708 arg1Of responses,immune
R1540 T3270 T3269 arg2Of patients,in
R1541 T3270 T3271 arg1Of patients,with
R1542 T3272 T3271 arg2Of RA,with
R1543 T3274 T3273 arg2Of in,than
R1544 T3275 T3274 arg2Of patients,in
R1545 T3275 T3276 arg1Of patients,with
R1546 T3277 T3276 arg2Of osteoarthritis,with
R1547 T3277 T3278 arg1Of osteoarthritis,(
R1548 T3279 T3278 arg2Of OA,(
R1549 T3280 T3278 arg3Of ),(
R155 T711 T710 arg1Of responses,inflammatory
R1550 T3282 T3281 arg1Of and,","
R1551 T3282 T3293 arg1Of and,[
R1552 T3283 T3284 arg1Of it,was
R1553 T3283 T3285 arg2Of it,produced
R1554 T3285 T3282 arg2Of produced,and
R1555 T3285 T3284 arg2Of produced,was
R1556 T3285 T3290 arg1Of produced,in
R1557 T3289 T3285 arg1Of cells,produced
R1558 T3289 T3286 arg2Of cells,by
R1559 T3289 T3287 arg1Of cells,CD4+
R156 T711 T712 arg1Of responses,","
R1560 T3289 T3288 arg1Of cells,T
R1561 T3292 T3290 arg2Of synovium,in
R1562 T3292 T3291 arg1Of synovium,the
R1563 T3294 T3293 arg2Of "11,12",[
R1564 T3295 T3293 arg3Of ],[
R1565 T3296 T3297 arg1Of IL-15,","
R1566 T3296 T3298 arg2Of IL-15,secreted
R1567 T3296 T3303 arg1Of IL-15,has
R1568 T3296 T3304 arg1Of IL-15,been
R1569 T3296 T3305 arg2Of IL-15,reported
R157 T711 T713 arg1Of responses,including
R1570 T3296 T3307 arg1Of IL-15,be
R1571 T3298 T3299 arg1Of secreted,from
R1572 T3301 T3299 arg2Of macrophages,from
R1573 T3301 T3300 arg2Of macrophages,activated
R1574 T3305 T3302 arg1Of reported,","
R1575 T3305 T3303 arg2Of reported,has
R1576 T3305 T3304 arg2Of reported,been
R1577 T3307 T3305 arg3Of be,reported
R1578 T3307 T3306 arg1Of be,to
R1579 T3307 T3314 arg1Of be,in
R158 T715 T713 arg2Of induction,including
R1580 T3307 T3323 arg1Of be,by
R1581 T3307 T3329 arg1Of be,[
R1582 T3310 T3307 arg2Of trigger,be
R1583 T3310 T3308 arg1Of trigger,an
R1584 T3310 T3309 arg1Of trigger,important
R1585 T3310 T3311 arg1Of trigger,of
R1586 T3313 T3311 arg2Of production,of
R1587 T3313 T3312 arg1Of production,IL-17
R1588 T3319 T3314 arg2Of cells,in
R1589 T3319 T3315 arg1Of cells,RA
R159 T715 T714 arg1Of induction,the
R1590 T3319 T3316 arg1Of cells,peripheral
R1591 T3319 T3317 arg1Of cells,blood
R1592 T3319 T3318 arg1Of cells,mononuclear
R1593 T3319 T3320 arg1Of cells,(
R1594 T3321 T3320 arg2Of PBMC,(
R1595 T3322 T3320 arg3Of ),(
R1596 T3324 T3325 arg1Of cyclosporine,and
R1597 T3325 T3323 arg2Of and,by
R1598 T3328 T3325 arg2Of pathways,and
R1599 T3328 T3326 arg1Of pathways,steroid
R160 T715 T716 arg1Of induction,of
R1600 T3328 T3327 arg1Of pathways,sensitive
R1601 T3330 T3329 arg2Of 13,[
R1602 T3331 T3329 arg3Of ],[
R1603 T3334 T3335 arg1Of Happel,and
R1604 T3335 T3338 arg1Of and,showed
R1605 T3336 T3335 arg2Of colleagues,and
R1606 T3338 T3332 arg1Of showed,Recently
R1607 T3338 T3333 arg1Of showed,","
R1608 T3338 T3337 arg1Of showed,also
R1609 T3340 T3341 arg1Of IL-23,could
R161 T718 T717 arg1Of cytokines,proinflammatory
R1610 T3340 T3342 arg1Of IL-23,be
R1611 T3342 T3338 arg2Of be,showed
R1612 T3342 T3339 arg1Of be,that
R1613 T3342 T3341 arg2Of be,could
R1614 T3345 T3342 arg2Of trigger,be
R1615 T3345 T3343 arg1Of trigger,an
R1616 T3345 T3344 arg1Of trigger,efficient
R1617 T3345 T3346 arg1Of trigger,of
R1618 T3345 T3349 arg1Of trigger,from
R1619 T3348 T3346 arg2Of production,of
R162 T718 T719 arg1Of cytokines,and
R1620 T3348 T3347 arg1Of production,IL-17
R1621 T3351 T3352 arg1Of CD4+,and
R1622 T3353 T3352 arg2Of CD8+,and
R1623 T3355 T3349 arg2Of cells,from
R1624 T3355 T3350 arg1Of cells,both
R1625 T3355 T3351 arg1Of cells,CD4+
R1626 T3355 T3353 arg1Of cells,CD8+
R1627 T3355 T3354 arg1Of cells,T
R1628 T3355 T3356 arg1Of cells,[
R1629 T3357 T3356 arg2Of 14,[
R163 T719 T716 arg2Of and,of
R1630 T3358 T3356 arg3Of ],[
R1631 T3361 T3360 arg1Of contribution,the
R1632 T3361 T3362 arg1Of contribution,of
R1633 T3361 T3364 arg1Of contribution,in
R1634 T3361 T3369 arg1Of contribution,has
R1635 T3361 T3370 arg1Of contribution,been
R1636 T3361 T3371 arg2Of contribution,documented
R1637 T3363 T3362 arg2Of IL-17,of
R1638 T3366 T3364 arg2Of inflammation,in
R1639 T3366 T3365 arg1Of inflammation,joint
R164 T722 T719 arg2Of resorption,and
R1640 T3366 T3367 arg1Of inflammation,in
R1641 T3368 T3367 arg2Of RA,in
R1642 T3371 T3359 arg2Of documented,Although
R1643 T3371 T3369 arg2Of documented,has
R1644 T3371 T3370 arg2Of documented,been
R1645 T3371 T3372 arg1Of documented,in
R1646 T3374 T3372 arg2Of studies,in
R1647 T3374 T3373 arg1Of studies,earlier
R1648 T3374 T3375 arg1Of studies,[
R1649 T3376 T3375 arg2Of "12,15,16",[
R165 T722 T720 arg1Of resorption,osteoclastic
R1650 T3377 T3375 arg3Of ],[
R1651 T3383 T3379 arg1Of pathway,the
R1652 T3383 T3380 arg1Of pathway,intracellular
R1653 T3383 T3381 arg1Of pathway,signal
R1654 T3383 T3382 arg1Of pathway,transduction
R1655 T3383 T3384 arg1Of pathway,for
R1656 T3383 T3387 arg1Of pathway,remains
R1657 T3383 T3388 arg1Of pathway,uncertain
R1658 T3386 T3384 arg2Of production,for
R1659 T3386 T3385 arg1Of production,IL-17
R166 T722 T721 arg1Of resorption,bone
R1660 T3387 T3359 arg1Of remains,Although
R1661 T3387 T3378 arg1Of remains,","
R1662 T3388 T3387 arg2Of uncertain,remains
R1663 T3392 T3389 arg2Of study,In
R1664 T3392 T3390 arg1Of study,the
R1665 T3392 T3391 arg1Of study,present
R1666 T3393 T3394 arg1Of we,used
R1667 T3393 T3398 arg1Of we,investigate
R1668 T3394 T3389 arg1Of used,In
R1669 T3396 T3394 arg2Of stimuli,used
R167 T723 T724 arg1Of Evidence,for
R1670 T3396 T3395 arg1Of stimuli,various
R1671 T3398 T3394 arg3Of investigate,used
R1672 T3398 T3397 arg1Of investigate,to
R1673 T3400 T3398 arg2Of production,investigate
R1674 T3400 T3399 arg1Of production,IL-17
R1675 T3400 T3401 arg1Of production,in
R1676 T3402 T3403 arg1Of PBMC,of
R1677 T3402 T3407 arg1Of PBMC,and
R1678 T3404 T3403 arg2Of patients,of
R1679 T3404 T3405 arg1Of patients,with
R168 T723 T727 arg1Of Evidence,and
R1680 T3406 T3405 arg2Of RA,with
R1681 T3407 T3401 arg2Of and,in
R1682 T3411 T3407 arg2Of pathway,and
R1683 T3411 T3408 arg1Of pathway,its
R1684 T3411 T3409 arg1Of pathway,signaling
R1685 T3411 T3410 arg1Of pathway,transduction
R1686 T3412 T3413 arg1Of We,found
R1687 T3418 T3415 arg1Of pathway,the
R1688 T3418 T3416 arg1Of pathway,intracellular
R1689 T3418 T3417 arg1Of pathway,signaling
R169 T726 T724 arg2Of expression,for
R1690 T3418 T3419 arg1Of pathway,involving
R1691 T3418 T3428 arg1Of pathway,might
R1692 T3418 T3429 arg1Of pathway,be
R1693 T3418 T3430 arg2Of pathway,involved
R1694 T3423 T3422 arg2Of PI3K,(
R1695 T3424 T3422 arg3Of ),(
R1696 T3425 T3426 arg1Of /Akt,and
R1697 T3426 T3419 arg2Of and,involving
R1698 T3426 T3420 arg1Of and,phosphoinositide
R1699 T3426 T3421 arg1Of and,3-kinase
R170 T726 T725 arg1Of expression,the
R1700 T3426 T3422 arg1Of and,(
R1701 T3427 T3426 arg2Of NF-κB,and
R1702 T3430 T3413 arg2Of involved,found
R1703 T3430 T3414 arg1Of involved,that
R1704 T3430 T3428 arg2Of involved,might
R1705 T3430 T3429 arg2Of involved,be
R1706 T3430 T3431 arg1Of involved,in
R1707 T3433 T3431 arg2Of overproduction,in
R1708 T3433 T3432 arg1Of overproduction,the
R1709 T3433 T3434 arg1Of overproduction,of
R171 T727 T732 arg1Of and,has
R1710 T3439 T3434 arg2Of IL-17,of
R1711 T3439 T3435 arg1Of IL-17,the
R1712 T3439 T3436 arg1Of IL-17,key
R1713 T3439 T3437 arg1Of IL-17,inflammatory
R1714 T3439 T3438 arg1Of IL-17,cytokine
R1715 T3439 T3440 arg1Of IL-17,in
R1716 T3441 T3440 arg2Of RA,in
R1717 T3443 T3442 arg1Of results,These
R1718 T3443 T3444 arg1Of results,might
R1719 T3443 T3445 arg1Of results,provide
R172 T727 T733 arg1Of and,been
R1720 T3445 T3444 arg2Of provide,might
R1721 T3445 T3448 arg1Of provide,into
R1722 T3447 T3445 arg2Of insights,provide
R1723 T3447 T3446 arg1Of insights,new
R1724 T3450 T3448 arg2Of pathogenesis,into
R1725 T3450 T3449 arg1Of pathogenesis,the
R1727 T3450 T3451 arg1Of pathogenesis,of
R1729 T3450 T3456 arg1Of pathogenesis,for
R173 T727 T734 arg2Of and,demonstrated
R1730 T3452 T3453 arg1Of RA,and
R1733 T3453 T3451 arg2Of and,of
R1734 T3455 T3453 arg2Of directions,and
R1735 T3455 T3454 arg1Of directions,future
R174 T729 T727 arg2Of activity,and
R1740 T3458 T3457 arg1Of therapeutic,new
R1742 T3459 T3456 arg2Of strategies,for
R1745 T3459 T3458 arg1Of strategies,therapeutic
R1747 T3459 T3460 arg1Of strategies,in
R1748 T3461 T3460 arg2Of RA,in
R175 T729 T728 arg1Of activity,proinflammatory
R176 T729 T730 arg1Of activity,of
R177 T731 T730 arg2Of IL-17,of
R178 T734 T732 arg2Of demonstrated,has
R179 T734 T733 arg2Of demonstrated,been
R180 T734 T735 arg1Of demonstrated,in
R181 T734 T739 arg1Of demonstrated,in
R182 T735 T738 arg1Of in,and
R183 T737 T735 arg2Of synovium,in
R184 T737 T736 arg1Of synovium,RA
R185 T739 T738 arg2Of in,and
R186 T741 T739 arg2Of models,in
R187 T741 T740 arg1Of models,animal
R188 T741 T742 arg1Of models,of
R189 T743 T742 arg2Of RA,of
R190 T746 T745 arg1Of cytokines,some
R191 T746 T747 arg1Of cytokines,(
R192 T746 T752 arg1Of cytokines,have
R193 T746 T753 arg1Of cytokines,been
R194 T746 T754 arg2Of cytokines,reported
R195 T746 T756 arg1Of cytokines,regulate
R196 T748 T749 arg1Of IL-15,and
R197 T749 T747 arg2Of and,(
R198 T750 T749 arg2Of IL-23,and
R199 T751 T747 arg3Of ),(
R200 T754 T744 arg2Of reported,Although
R201 T754 T752 arg2Of reported,have
R202 T754 T753 arg2Of reported,been
R203 T756 T754 arg3Of regulate,reported
R204 T756 T755 arg1Of regulate,to
R205 T758 T756 arg2Of production,regulate
R206 T758 T757 arg1Of production,IL-17
R207 T763 T760 arg1Of pathways,the
R208 T763 T761 arg1Of pathways,intracellular
R209 T763 T762 arg1Of pathways,signaling
R210 T763 T764 arg1Of pathways,that
R211 T763 T765 arg1Of pathways,regulate
R212 T763 T768 arg1Of pathways,remain
R213 T763 T769 arg1Of pathways,unknown
R214 T767 T765 arg2Of production,regulate
R215 T767 T766 arg1Of production,IL-17
R216 T768 T744 arg1Of remain,Although
R217 T768 T759 arg1Of remain,","
R218 T769 T768 arg2Of unknown,remain
R219 T773 T770 arg2Of study,In
R220 T773 T771 arg1Of study,the
R221 T773 T772 arg1Of study,present
R222 T775 T776 arg1Of we,investigated
R223 T776 T770 arg1Of investigated,In
R224 T776 T774 arg1Of investigated,","
R225 T778 T776 arg2Of role,investigated
R226 T778 T777 arg1Of role,the
R227 T778 T779 arg1Of role,of
R228 T778 T788 arg1Of role,in
R229 T784 T783 arg2Of PI3K,(
R230 T785 T783 arg3Of ),(
R231 T787 T779 arg2Of pathway,of
R232 T787 T780 arg1Of pathway,the
R233 T787 T781 arg1Of pathway,phosphoinositide
R234 T787 T782 arg1Of pathway,3-kinase
R235 T787 T783 arg1Of pathway,(
R236 T787 T786 arg1Of pathway,/Akt
R237 T790 T788 arg2Of regulation,in
R238 T790 T789 arg1Of regulation,the
R239 T790 T791 arg1Of regulation,of
R240 T793 T791 arg2Of production,of
R241 T793 T792 arg1Of production,IL-17
R242 T793 T794 arg1Of production,in
R243 T795 T794 arg2Of RA,in
R244 T799 T796 arg1Of cells,Peripheral
R245 T799 T797 arg1Of cells,blood
R246 T799 T798 arg1Of cells,mononuclear
R247 T799 T800 arg1Of cells,(
R248 T799 T803 arg1Of cells,from
R2483 T4883 T4882 arg2Of consent,Informed
R2484 T4883 T4884 arg1Of consent,was
R2485 T4883 T4885 arg2Of consent,obtained
R2486 T4885 T4884 arg2Of obtained,was
R2487 T4885 T4886 arg1Of obtained,from
R2488 T4888 T4886 arg2Of patients,from
R2489 T4888 T4887 arg1Of patients,24
R249 T799 T812 arg1Of cells,were
R2490 T4888 T4889 arg1Of patients,(
R2491 T4888 T4896 arg1Of patients,with
R2492 T4891 T4890 arg1Of men,5
R2493 T4891 T4892 arg1Of men,and
R2494 T4892 T4889 arg2Of and,(
R2495 T4894 T4892 arg2Of women,and
R2496 T4894 T4893 arg1Of women,19
R2497 T4895 T4889 arg3Of ),(
R2498 T4897 T4896 arg2Of RA,with
R2499 T4897 T4898 arg1Of RA,who
R250 T799 T813 arg2Of cells,separated
R2500 T4897 T4899 arg1Of RA,fulfilled
R2501 T4899 T4917 arg1Of fulfilled,[
R2502 T4903 T4899 arg2Of criteria,fulfilled
R2503 T4903 T4900 arg1Of criteria,the
R2504 T4903 T4901 arg1Of criteria,1987
R2505 T4903 T4902 arg2Of criteria,revised
R2506 T4903 T4904 arg1Of criteria,of
R2507 T4903 T4910 arg1Of criteria,(
R2508 T4907 T4904 arg2Of College,of
R2509 T4907 T4905 arg1Of College,the
R251 T799 T816 arg2Of cells,stimulated
R2510 T4907 T4906 arg1Of College,American
R2511 T4907 T4908 arg1Of College,of
R2512 T4909 T4908 arg2Of Rheumatology,of
R2513 T4915 T4910 arg2Of Association,(
R2514 T4915 T4911 arg1Of Association,formerly
R2515 T4915 T4912 arg1Of Association,the
R2516 T4915 T4913 arg1Of Association,American
R2517 T4915 T4914 arg1Of Association,Rheumatism
R2518 T4916 T4910 arg3Of ),(
R2519 T4918 T4917 arg2Of 17,[
R252 T801 T800 arg2Of PBMC,(
R2520 T4919 T4917 arg3Of ],[
R2521 T4921 T4920 arg1Of age,The
R2522 T4921 T4922 arg1Of age,of
R2523 T4921 T4927 arg1Of age,was
R2524 T4924 T4922 arg2Of patients,of
R2525 T4924 T4923 arg1Of patients,the
R2526 T4924 T4925 arg1Of patients,with
R2527 T4926 T4925 arg2Of RA,with
R2528 T4932 T4933 arg1Of mean,±
R2529 T4933 T4931 arg2Of ±,(
R253 T802 T800 arg3Of ),(
R2530 T4934 T4933 arg2Of SEM,±
R2531 T4935 T4931 arg3Of ),(
R2532 T4936 T4927 arg2Of years,was
R2533 T4936 T4928 arg1Of years,50
R2534 T4936 T4929 arg1Of years,±
R2535 T4936 T4930 arg1Of years,8
R2536 T4936 T4931 arg1Of years,(
R2537 T4936 T4937 arg1Of years,(
R2538 T4940 T4937 arg2Of years,(
R2539 T4940 T4938 arg1Of years,range
R254 T804 T803 arg2Of patients,from
R2540 T4940 T4939 arg1Of years,23–71
R2541 T4941 T4937 arg3Of ),(
R2542 T4943 T4942 arg1Of medications,All
R2543 T4943 T4944 arg1Of medications,were
R2544 T4943 T4945 arg2Of medications,stopped
R2545 T4945 T4944 arg2Of stopped,were
R2546 T4945 T4948 arg1Of stopped,before
R2547 T4947 T4946 arg1Of hours,48
R2548 T4948 T4947 arg1Of before,hours
R2549 T4949 T4948 arg2Of entry,before
R255 T804 T805 arg1Of patients,with
R2550 T4949 T4950 arg1Of entry,to
R2551 T4952 T4950 arg2Of study,to
R2552 T4952 T4951 arg1Of study,the
R2553 T4953 T4954 arg1Of Comparisons,were
R2554 T4953 T4955 arg2Of Comparisons,made
R2555 T4955 T4954 arg2Of made,were
R2556 T4955 T4956 arg1Of made,with
R2557 T4955 T4969 arg1Of made,with
R2558 T4956 T4968 arg1Of with,and
R2559 T4958 T4956 arg2Of patients,with
R256 T806 T805 arg2Of RA,with
R2560 T4958 T4957 arg1Of patients,14
R2561 T4958 T4959 arg1Of patients,with
R2562 T4958 T4961 arg1Of patients,(
R2563 T4960 T4959 arg2Of OA,with
R2564 T4963 T4962 arg1Of men,3
R2565 T4963 T4964 arg1Of men,and
R2566 T4964 T4961 arg2Of and,(
R2567 T4966 T4964 arg2Of women,and
R2568 T4966 T4965 arg1Of women,11
R2569 T4967 T4961 arg3Of ),(
R257 T806 T807 arg1Of RA,(
R2570 T4969 T4968 arg2Of with,and
R2571 T4972 T4969 arg2Of controls,with
R2572 T4972 T4970 arg1Of controls,14
R2573 T4972 T4971 arg1Of controls,healthy
R2574 T4972 T4973 arg1Of controls,(
R2575 T4972 T4980 arg1Of controls,who
R2576 T4972 T4981 arg1Of controls,had
R2577 T4975 T4974 arg1Of men,3
R2578 T4975 T4976 arg1Of men,and
R2579 T4976 T4973 arg2Of and,(
R258 T808 T807 arg2Of n,(
R2580 T4978 T4976 arg2Of women,and
R2581 T4978 T4977 arg1Of women,11
R2582 T4979 T4973 arg3Of ),(
R2583 T4984 T4981 arg2Of diseases,had
R2584 T4984 T4982 arg1Of diseases,no
R2585 T4984 T4983 arg1Of diseases,rheumatic
R2586 T4987 T4985 arg1Of ages,The
R2587 T4987 T4986 arg1Of ages,mean
R2588 T4987 T4988 arg1Of ages,of
R2589 T4987 T4997 arg1Of ages,were
R259 T808 T809 arg1Of n,=
R2590 T4990 T4989 arg1Of patients,the
R2591 T4990 T4991 arg1Of patients,with
R2592 T4990 T4993 arg1Of patients,and
R2593 T4992 T4991 arg2Of OA,with
R2594 T4993 T4988 arg2Of and,of
R2595 T4996 T4993 arg2Of controls,and
R2596 T4996 T4994 arg1Of controls,the
R2597 T4996 T4995 arg1Of controls,healthy
R2598 T4998 T4999 arg1Of 50,±
R2599 T5000 T4999 arg2Of 8,±
R260 T809 T810 arg1Of =,24
R2600 T5001 T4998 arg1Of years,50
R2601 T5001 T5000 arg1Of years,8
R2602 T5001 T5002 arg1Of years,(
R2603 T5001 T5007 arg1Of years,and
R2604 T5005 T5002 arg2Of years,(
R2605 T5005 T5003 arg1Of years,range
R2606 T5005 T5004 arg1Of years,34–68
R2607 T5006 T5002 arg3Of ),(
R2608 T5007 T4997 arg2Of and,were
R2609 T5008 T5009 arg1Of 30,±
R261 T811 T807 arg3Of ),(
R2610 T5010 T5009 arg2Of 6,±
R2611 T5011 T5007 arg2Of years,and
R2612 T5011 T5008 arg1Of years,30
R2613 T5011 T5010 arg1Of years,6
R2614 T5011 T5012 arg1Of years,(
R2615 T5015 T5012 arg2Of years,(
R2616 T5015 T5013 arg1Of years,range
R2617 T5015 T5014 arg1Of years,24–57
R2618 T5016 T5012 arg3Of ),(
R2619 T5018 T5017 arg2Of consent,Informed
R262 T813 T814 arg1Of separated,","
R2620 T5018 T5019 arg1Of consent,was
R2621 T5018 T5020 arg2Of consent,obtained
R2622 T5020 T5019 arg2Of obtained,was
R2623 T5020 T5022 arg1Of obtained,and
R2624 T5022 T5021 arg1Of and,","
R2625 T5024 T5023 arg1Of protocol,the
R2626 T5024 T5025 arg1Of protocol,was
R2627 T5024 T5026 arg2Of protocol,approved
R2628 T5026 T5022 arg2Of approved,and
R2629 T5026 T5025 arg2Of approved,was
R263 T814 T812 arg2Of ",",were
R2630 T5030 T5026 arg1Of University,approved
R2631 T5030 T5027 arg2Of University,by
R2632 T5030 T5028 arg1Of University,the
R2633 T5030 T5029 arg1Of University,Catholic
R2634 T5030 T5031 arg1Of University,of
R2635 T5036 T5031 arg2Of Committee,of
R2636 T5036 T5032 arg1Of Committee,Korea
R2637 T5036 T5033 arg1Of Committee,Human
R2638 T5036 T5034 arg1Of Committee,Research
R2639 T5036 T5035 arg1Of Committee,Ethics
R264 T816 T814 arg2Of stimulated,","
R265 T816 T815 arg1Of stimulated,then
R266 T816 T817 arg1Of stimulated,with
R267 T819 T817 arg2Of agents,with
R268 T819 T818 arg1Of agents,various
R269 T819 T820 arg1Of agents,including
R270 T821 T822 arg1Of anti-CD3,","
R271 T822 T824 arg1Of ",",","
R272 T823 T822 arg2Of anti-CD28,","
R273 T824 T829 arg1Of ",",and
R274 T825 T824 arg2Of phytohemagglutinin,","
R275 T825 T826 arg1Of phytohemagglutinin,(
R276 T827 T826 arg2Of PHA,(
R277 T828 T826 arg3Of ),(
R278 T829 T833 arg1Of and,and
R279 T832 T829 arg2Of cytokines,and
R280 T832 T830 arg1Of cytokines,several
R281 T832 T831 arg1Of cytokines,inflammatory
R2810 T5376 T5375 arg1Of IL-17,Recombinant
R2811 T5376 T5377 arg1Of IL-17,","
R2812 T5377 T5379 arg1Of ",",","
R2813 T5378 T5377 arg2Of IL-18,","
R2814 T5379 T5381 arg1Of ",",","
R2815 T5380 T5379 arg2Of IL-15,","
R2816 T5381 T5388 arg1Of ",",","
R2817 T5384 T5381 arg2Of protein-1,","
R2818 T5384 T5382 arg1Of protein-1,monocyte
R2819 T5384 T5383 arg1Of protein-1,chemoattractant
R282 T833 T820 arg2Of and,including
R2820 T5384 T5385 arg1Of protein-1,(
R2821 T5386 T5385 arg2Of MCP-1,(
R2822 T5387 T5385 arg3Of ),(
R2823 T5388 T5402 arg1Of ",",were
R2824 T5388 T5403 arg2Of ",",purchased
R2825 T5391 T5389 arg1Of protein,macrophage
R2826 T5391 T5390 arg1Of protein,inflammatory
R2827 T5391 T5392 arg1Of protein,(
R2828 T5393 T5392 arg2Of MIP,(
R2829 T5394 T5392 arg3Of ),(
R283 T834 T833 arg2Of chemokines,and
R2830 T5395 T5396 arg1Of -1α,","
R2831 T5396 T5398 arg1Of ",",","
R2832 T5397 T5396 arg2Of MIP-1β,","
R2833 T5398 T5400 arg1Of ",",and
R2834 T5399 T5398 arg2Of IL-6,","
R2835 T5400 T5388 arg2Of and,","
R2836 T5400 T5391 arg1Of and,protein
R2837 T5401 T5400 arg2Of IL-8,and
R2838 T5403 T5402 arg2Of purchased,were
R2839 T5403 T5404 arg1Of purchased,from
R284 T836 T835 arg1Of levels,IL-17
R2840 T5403 T5409 arg1Of purchased,(
R2841 T5408 T5404 arg2Of systems,from
R2842 T5408 T5405 arg1Of systems,R
R2843 T5408 T5406 arg1Of systems,&
R2844 T5408 T5407 arg1Of systems,D
R2845 T5410 T5411 arg1Of Minneapolis,","
R2846 T5411 T5409 arg2Of ",",(
R2847 T5411 T5413 arg1Of ",",","
R2848 T5412 T5411 arg2Of MN,","
R2849 T5414 T5413 arg2Of USA,","
R285 T836 T837 arg1Of levels,were
R2850 T5415 T5409 arg3Of ),(
R2851 T5421 T5420 arg2Of TGF,(
R2852 T5422 T5420 arg3Of ),(
R2853 T5423 T5416 arg1Of -β,Recombinant
R2854 T5423 T5417 arg1Of -β,transforming
R2855 T5423 T5418 arg1Of -β,growth
R2856 T5423 T5419 arg1Of -β,factor
R2857 T5423 T5420 arg1Of -β,(
R2858 T5423 T5424 arg1Of -β,was
R2859 T5423 T5425 arg2Of -β,purchased
R286 T836 T838 arg2Of levels,determined
R2860 T5425 T5424 arg2Of purchased,was
R2861 T5425 T5426 arg1Of purchased,from
R2862 T5427 T5426 arg2Of Peprotech,from
R2863 T5427 T5428 arg1Of Peprotech,(
R2864 T5429 T5428 arg2Of London,(
R2865 T5429 T5430 arg1Of London,","
R2866 T5429 T5431 arg1Of London,UK
R2867 T5432 T5428 arg3Of ),(
R2868 T5434 T5435 arg1Of TNF-α,and
R2869 T5435 T5433 arg1Of and,Recombinant
R287 T838 T837 arg2Of determined,were
R2870 T5435 T5437 arg1Of and,were
R2871 T5435 T5438 arg2Of and,purchased
R2872 T5436 T5435 arg2Of IL-1,and
R2873 T5438 T5437 arg2Of purchased,were
R2874 T5438 T5439 arg1Of purchased,from
R2875 T5441 T5439 arg2Of Inc.,from
R2876 T5441 T5440 arg1Of Inc.,Endogen
R2877 T5441 T5442 arg1Of Inc.,(
R2878 T5443 T5442 arg2Of Cambridge,(
R2879 T5443 T5444 arg1Of Cambridge,","
R288 T843 T840 arg1Of assay,sandwich
R2880 T5443 T5446 arg1Of Cambridge,","
R2881 T5445 T5444 arg2Of MA,","
R2882 T5447 T5446 arg2Of USA,","
R2883 T5448 T5442 arg3Of ),(
R2884 T5450 T5449 arg1Of A,Cyclosporin
R2885 T5450 T5451 arg1Of A,was
R2886 T5450 T5452 arg2Of A,provided
R2887 T5452 T5451 arg2Of provided,was
R2888 T5455 T5452 arg1Of Ltd.,provided
R2889 T5455 T5453 arg2Of Ltd.,by
R289 T843 T841 arg1Of assay,enzyme-linked
R2890 T5455 T5454 arg1Of Ltd.,Sandos
R2891 T5455 T5456 arg1Of Ltd.,(
R2892 T5457 T5456 arg2Of Basel,(
R2893 T5457 T5458 arg1Of Basel,","
R2894 T5459 T5458 arg2Of Switzerland,","
R2895 T5460 T5456 arg3Of ),(
R2896 T5461 T5462 arg1Of Phytohemagglutinin,(
R2897 T5461 T5465 arg1Of Phytohemagglutinin,","
R2898 T5463 T5462 arg2Of PHA,(
R2899 T5464 T5462 arg3Of ),(
R290 T843 T842 arg1Of assay,immunosorbent
R2900 T5465 T5471 arg1Of ",",","
R2901 T5467 T5465 arg2Of dithiocarbamate,","
R2902 T5467 T5466 arg1Of dithiocarbamate,pyrrolidine
R2903 T5467 T5468 arg1Of dithiocarbamate,(
R2904 T5469 T5468 arg2Of PDTC,(
R2905 T5470 T5468 arg3Of ),(
R2906 T5471 T5473 arg1Of ",",","
R2907 T5472 T5471 arg2Of rapamycin,","
R2908 T5473 T5475 arg1Of ",",and
R2909 T5474 T5473 arg2Of dexamethasone,","
R291 T843 T844 arg1Of assay,and
R2910 T5475 T5477 arg1Of and,were
R2911 T5475 T5479 arg2Of and,obtained
R2912 T5476 T5475 arg2Of curcumin,and
R2913 T5479 T5477 arg2Of obtained,were
R2914 T5479 T5478 arg1Of obtained,all
R2915 T5479 T5480 arg1Of obtained,from
R2916 T5484 T5480 arg2Of Co.,from
R2917 T5484 T5481 arg1Of Co.,the
R2918 T5484 T5482 arg1Of Co.,Sigma
R2919 T5484 T5483 arg1Of Co.,Chemical
R292 T844 T838 arg1Of and,determined
R2920 T5484 T5485 arg1Of Co.,(
R2921 T5487 T5485 arg2Of Louis,(
R2922 T5487 T5486 arg1Of Louis,St
R2923 T5487 T5488 arg1Of Louis,","
R2924 T5489 T5488 arg2Of MA,","
R2925 T5489 T5490 arg1Of MA,","
R2926 T5491 T5490 arg2Of USA,","
R2927 T5492 T5485 arg3Of ),(
R2928 T5495 T5493 arg1Of antibody,Anti-CD3
R2929 T5495 T5494 arg1Of antibody,monoclonal
R293 T844 T839 arg2Of and,by
R2930 T5495 T5496 arg1Of antibody,and
R2931 T5496 T5500 arg1Of and,were
R2932 T5496 T5501 arg2Of and,obtained
R2933 T5499 T5496 arg2Of antibody,and
R2934 T5499 T5497 arg1Of antibody,anti-CD28
R2935 T5499 T5498 arg1Of antibody,monoclonal
R2936 T5501 T5500 arg2Of obtained,were
R2937 T5501 T5502 arg1Of obtained,from
R2938 T5504 T5502 arg2Of Biosciences,from
R2939 T5504 T5503 arg1Of Biosciences,BD
R294 T848 T844 arg2Of reaction,and
R2940 T5504 T5505 arg1Of Biosciences,(
R2941 T5507 T5505 arg2Of Diego,(
R2942 T5507 T5506 arg1Of Diego,San
R2943 T5507 T5508 arg1Of Diego,","
R2944 T5509 T5508 arg2Of CA,","
R2945 T5509 T5510 arg1Of CA,","
R2946 T5511 T5510 arg2Of USA,","
R2947 T5512 T5505 arg3Of ),(
R2948 T5513 T5514 arg1Of LY294002,","
R2949 T5514 T5516 arg1Of ",",","
R295 T848 T845 arg1Of reaction,reverse
R2950 T5515 T5514 arg2Of SB203580,","
R2951 T5516 T5518 arg1Of ",",","
R2952 T5517 T5516 arg2Of FK506,","
R2953 T5518 T5520 arg1Of ",",and
R2954 T5519 T5518 arg2Of wortmannin,","
R2955 T5520 T5522 arg1Of and,were
R2956 T5520 T5523 arg2Of and,obtained
R2957 T5521 T5520 arg2Of PD98059,and
R2958 T5523 T5522 arg2Of obtained,were
R2959 T5523 T5524 arg1Of obtained,from
R296 T848 T846 arg1Of reaction,transcription–polymerase
R2960 T5523 T5526 arg1Of obtained,(
R2961 T5525 T5524 arg2Of Calbiochem,from
R2962 T5527 T5526 arg2Of Schwalbach,(
R2963 T5527 T5528 arg1Of Schwalbach,","
R2964 T5529 T5528 arg2Of Germany,","
R2965 T5530 T5526 arg3Of ),(
R297 T848 T847 arg1Of reaction,chain
R298 T850 T849 arg1Of production,The
R299 T850 T851 arg1Of production,of
R300 T850 T853 arg1Of production,was
R301 T850 T855 arg2Of production,increased
R302 T852 T851 arg2Of IL-17,of
R303 T855 T853 arg2Of increased,was
R304 T855 T854 arg1Of increased,significantly
R305 T855 T856 arg1Of increased,in
R306 T857 T856 arg2Of cells,in
R307 T857 T858 arg2Of cells,treated
R308 T858 T859 arg1Of treated,with
R309 T861 T859 arg2Of antibody,with
R310 T861 T860 arg1Of antibody,anti-CD3
R311 T861 T862 arg1Of antibody,with
R312 T861 T864 arg1Of antibody,without
R313 T862 T863 arg1Of with,or
R314 T864 T863 arg2Of without,or
R3144 T6095 T6096 arg1Of Production,of
R3145 T6095 T6098 arg1Of Production,by
R3146 T6097 T6096 arg2Of IL-17,of
R3147 T6102 T6099 arg1Of activation,T
R3148 T6102 T6100 arg1Of activation,cell
R3149 T6102 T6101 arg1Of activation,receptor
R315 T865 T866 arg1Of anti-CD28,and
R3150 T6102 T6103 arg1Of activation,","
R3151 T6103 T6105 arg1Of ",",or
R3152 T6104 T6103 arg2Of cytokines,","
R3153 T6105 T6098 arg2Of or,by
R3154 T6106 T6105 arg2Of chemokines,or
R3155 T6107 T6108 arg1Of PBMC,were
R3156 T6107 T6109 arg2Of PBMC,prepared
R3157 T6109 T6108 arg2Of prepared,were
R3158 T6109 T6110 arg1Of prepared,from
R3159 T6112 T6110 arg2Of blood,from
R316 T866 T862 arg2Of and,with
R3160 T6112 T6111 arg2Of blood,heparinized
R3161 T6116 T6115 arg2Of SG1077,(
R3162 T6117 T6115 arg3Of ),(
R3163 T6119 T6109 arg1Of centrifugation,prepared
R3164 T6119 T6113 arg2Of centrifugation,by
R3165 T6119 T6114 arg1Of centrifugation,Ficoll-Hypaque
R3166 T6119 T6115 arg1Of centrifugation,(
R3167 T6119 T6118 arg1Of centrifugation,density-gradient
R3168 T6121 T6120 arg1Of cultures,Cell
R3169 T6121 T6122 arg1Of cultures,were
R317 T866 T864 arg2Of and,without
R3170 T6121 T6123 arg2Of cultures,performed
R3171 T6123 T6122 arg2Of performed,were
R3172 T6123 T6124 arg1Of performed,as
R3173 T6123 T6127 arg1Of performed,[
R3174 T6125 T6124 arg2Of described,as
R3175 T6125 T6126 arg1Of described,previously
R3176 T6128 T6127 arg2Of 18,[
R3177 T6129 T6127 arg3Of ],[
R3178 T6131 T6130 arg2Of brief,In
R3179 T6135 T6133 arg1Of suspensions,the
R318 T866 T868 arg1Of and,(
R3180 T6135 T6134 arg1Of suspensions,cell
R3181 T6135 T6136 arg1Of suspensions,were
R3182 T6135 T6137 arg2Of suspensions,adjusted
R3183 T6137 T6130 arg1Of adjusted,In
R3184 T6137 T6132 arg1Of adjusted,","
R3185 T6137 T6136 arg2Of adjusted,were
R3186 T6137 T6138 arg1Of adjusted,to
R3187 T6140 T6138 arg2Of concentration,to
R3188 T6140 T6139 arg1Of concentration,a
R3189 T6140 T6141 arg1Of concentration,of
R319 T867 T866 arg2Of PHA,and
R3190 T6140 T6143 arg1Of concentration,in
R3191 T6142 T6141 arg2Of 106/ml,of
R3192 T6146 T6143 arg2Of medium,in
R3193 T6146 T6144 arg1Of medium,RPMI
R3194 T6146 T6145 arg1Of medium,1640
R3195 T6146 T6147 arg2Of medium,supplemented
R3196 T6147 T6148 arg1Of supplemented,with
R3197 T6149 T6150 arg1Of 10,%
R3198 T6153 T6149 arg1Of serum,10
R3199 T6153 T6151 arg1Of serum,fetal
R320 T869 T868 arg2Of P,(
R3200 T6153 T6152 arg1Of serum,calf
R3201 T6153 T6154 arg1Of serum,","
R3202 T6154 T6158 arg1Of ",",","
R3203 T6157 T6154 arg2Of penicillin,","
R3204 T6157 T6155 arg1Of penicillin,100
R3205 T6157 T6156 arg1Of penicillin,U/ml
R3206 T6158 T6162 arg1Of ",",and
R3207 T6159 T6160 arg1Of 100,mg/ml
R3208 T6161 T6158 arg2Of streptomycin,","
R3209 T6161 T6159 arg1Of streptomycin,100
R321 T869 T870 arg1Of P,<
R3210 T6162 T6148 arg2Of and,with
R3211 T6163 T6164 arg1Of 2,mM
R3212 T6165 T6162 arg2Of L-glutamine,and
R3213 T6165 T6163 arg1Of L-glutamine,2
R3214 T6167 T6166 arg1Of suspension,Cell
R3215 T6167 T6168 arg1Of suspension,(
R3216 T6167 T6172 arg1Of suspension,was
R3217 T6167 T6173 arg2Of suspension,dispensed
R3218 T6167 T6187 arg2Of suspension,incubated
R3219 T6170 T6168 arg2Of ml,(
R322 T869 T871 arg1Of P,0.05
R3220 T6170 T6169 arg1Of ml,1
R3221 T6171 T6168 arg3Of ),(
R3222 T6173 T6174 arg1Of dispensed,into
R3223 T6173 T6178 arg1Of dispensed,(
R3224 T6173 T6186 arg1Of dispensed,and
R3225 T6177 T6174 arg2Of plates,into
R3226 T6177 T6175 arg1Of plates,24-well
R3227 T6177 T6176 arg1Of plates,multi-well
R3228 T6179 T6180 arg1Of Nunc,","
R3229 T6180 T6182 arg1Of ",",","
R323 T872 T868 arg3Of ),(
R3230 T6181 T6180 arg2Of Roskilde,","
R3231 T6182 T6178 arg2Of ",",(
R3232 T6183 T6182 arg2Of Denmark,","
R3233 T6184 T6178 arg3Of ),(
R3234 T6186 T6172 arg2Of and,was
R3235 T6186 T6185 arg1Of and,","
R3236 T6187 T6186 arg2Of incubated,and
R3237 T6187 T6188 arg1Of incubated,for
R3238 T6187 T6191 arg1Of incubated,at
R3239 T6190 T6188 arg2Of hours,for
R324 T875 T876 arg1Of cytokines,and
R3240 T6190 T6189 arg1Of hours,24
R3241 T6192 T6191 arg2Of 37°C,at
R3242 T6192 T6193 arg1Of 37°C,in
R3243 T6194 T6195 arg1Of 5,%
R3244 T6196 T6193 arg2Of CO2,in
R3245 T6196 T6194 arg1Of CO2,5
R3246 T6200 T6199 arg1Of concentrations,various
R3247 T6200 T6201 arg1Of concentrations,of
R3248 T6200 T6208 arg1Of concentrations,were
R3249 T6200 T6209 arg2Of concentrations,added
R325 T876 T873 arg2Of and,Among
R3250 T6203 T6201 arg2Of A,of
R3251 T6203 T6202 arg1Of A,cyclosporin
R3252 T6203 T6204 arg1Of A,(
R3253 T6206 T6204 arg2Of ng/ml,(
R3254 T6206 T6205 arg1Of ng/ml,10–500
R3255 T6207 T6204 arg3Of ),(
R3256 T6209 T6208 arg2Of added,were
R3257 T6209 T6210 arg1Of added,to
R3258 T6209 T6213 arg1Of added,and
R3259 T6212 T6210 arg2Of medium,to
R326 T876 T874 arg2Of and,tested
R3260 T6212 T6211 arg1Of medium,the
R3261 T6213 T6197 arg1Of and,Subsequently
R3262 T6213 T6198 arg1Of and,","
R3263 T6214 T6215 arg1Of cells,were
R3264 T6214 T6216 arg2Of cells,incubated
R3265 T6216 T6213 arg2Of incubated,and
R3266 T6216 T6215 arg2Of incubated,were
R3267 T6216 T6217 arg1Of incubated,for
R3268 T6219 T6217 arg2Of hours,for
R3269 T6219 T6218 arg1Of hours,24
R327 T877 T876 arg2Of chemokines,and
R3270 T6222 T6220 arg1Of well,To
R3271 T6222 T6221 arg1Of well,each
R3272 T6222 T6223 arg1Of well,was
R3273 T6222 T6224 arg2Of well,added
R3274 T6224 T6223 arg2Of added,was
R3275 T6225 T6226 arg1Of FK506,","
R3276 T6226 T6228 arg1Of ",",","
R3277 T6227 T6226 arg2Of rapamycin,","
R3278 T6228 T6230 arg1Of ",",","
R3279 T6229 T6228 arg2Of curcumin,","
R328 T879 T880 arg1Of IL-15,","
R3280 T6230 T6232 arg1Of ",",","
R3281 T6231 T6230 arg2Of PDTC,","
R3282 T6232 T6234 arg1Of ",",","
R3283 T6233 T6232 arg2Of LY294002,","
R3284 T6234 T6224 arg3Of ",",added
R3285 T6235 T6236 arg1Of SB203580,","
R3286 T6236 T6238 arg1Of ",",","
R3287 T6237 T6236 arg2Of PD98059,","
R3288 T6238 T6240 arg1Of ",",or
R3289 T6239 T6238 arg2Of dexamethasone,","
R329 T880 T884 arg1Of ",",and
R3290 T6240 T6234 arg2Of or,","
R3291 T6241 T6240 arg2Of wortmannin,or
R3292 T6243 T6242 arg2Of incubation,After
R3293 T6246 T6244 arg2Of hours,for
R3294 T6246 T6245 arg1Of hours,24
R3295 T6254 T6253 arg1Of media,cell-free
R3296 T6254 T6255 arg1Of media,were
R3297 T6254 T6256 arg2Of media,collected
R3298 T6254 T6258 arg2Of media,stored
R3299 T6256 T6257 arg1Of collected,and
R330 T883 T880 arg2Of protein-1,","
R3300 T6257 T6252 arg1Of and,","
R3301 T6257 T6255 arg2Of and,were
R3302 T6257 T6261 arg1Of and,until
R3303 T6258 T6257 arg2Of stored,and
R3304 T6258 T6259 arg1Of stored,at
R3305 T6260 T6259 arg2Of -20°C,at
R3306 T6262 T6261 arg2Of assayed,until
R3307 T6264 T6263 arg1Of cultures,All
R3308 T6264 T6265 arg1Of cultures,were
R3309 T6264 T6266 arg2Of cultures,set
R331 T883 T881 arg1Of protein-1,monocyte
R3310 T6266 T6265 arg2Of set,were
R3311 T6266 T6267 arg1Of set,up
R3312 T6266 T6268 arg1Of set,in
R3313 T6266 T6271 arg1Of set,and
R3314 T6269 T6268 arg2Of triplicate,in
R3315 T6271 T6270 arg1Of and,","
R3316 T6272 T6273 arg1Of results,are
R3317 T6272 T6274 arg2Of results,expressed
R3318 T6274 T6271 arg2Of expressed,and
R3319 T6274 T6273 arg2Of expressed,are
R332 T883 T882 arg1Of protein-1,chemoattractant
R3320 T6274 T6275 arg1Of expressed,as
R3321 T6276 T6277 arg1Of means,±
R3322 T6277 T6275 arg2Of ±,as
R3323 T6278 T6277 arg2Of SEM,±
R333 T884 T886 arg1Of and,upregulated
R334 T885 T884 arg2Of IL-6,and
R335 T886 T873 arg1Of upregulated,Among
R336 T886 T878 arg1Of upregulated,","
R337 T886 T894 arg1Of upregulated,","
R338 T886 T895 arg1Of upregulated,whereas
R339 T888 T886 arg2Of production,upregulated
R340 T888 T887 arg1Of production,IL-17
R341 T888 T889 arg1Of production,(
R342 T890 T889 arg2Of P,(
R343 T890 T891 arg1Of P,<
R344 T890 T892 arg1Of P,0.05
R345 T893 T889 arg3Of ),(
R346 T898 T896 arg1Of factor-α,tumor
R347 T898 T897 arg1Of factor-α,necrosis
R348 T898 T899 arg1Of factor-α,","
R349 T899 T901 arg1Of ",",","
R350 T900 T899 arg2Of IL-1β,","
R351 T901 T903 arg1Of ",",or
R352 T902 T901 arg2Of IL-18,","
R3527 T6741 T6739 arg1Of isolation,CD4+
R3528 T6741 T6740 arg1Of isolation,T-cell
R3529 T6741 T6742 arg1Of isolation,by
R353 T903 T907 arg1Of or,did
R3530 T6743 T6742 arg2Of MACS,by
R3531 T6745 T6744 arg1Of microbeads,Anti-CD4
R3532 T6745 T6746 arg1Of microbeads,were
R3533 T6745 T6747 arg2Of microbeads,used
R3534 T6747 T6746 arg2Of used,were
R3535 T6747 T6748 arg1Of used,essentially
R3536 T6747 T6749 arg1Of used,as
R3537 T6747 T6757 arg1Of used,[
R3538 T6750 T6749 arg2Of recommended,as
R3539 T6750 T6754 arg1Of recommended,(
R354 T906 T903 arg2Of factor-β,or
R3540 T6753 T6750 arg1Of manufacturer,recommended
R3541 T6753 T6751 arg2Of manufacturer,by
R3542 T6753 T6752 arg1Of manufacturer,the
R3543 T6755 T6754 arg2Of Miltenyi,(
R3544 T6756 T6754 arg3Of ),(
R3545 T6758 T6757 arg2Of 19,[
R3546 T6759 T6757 arg3Of ],[
R3547 T6760 T6761 arg1Of PBMC,were
R3548 T6760 T6762 arg2Of PBMC,resuspended
R3549 T6762 T6761 arg2Of resuspended,were
R355 T906 T904 arg1Of factor-β,transforming
R3550 T6762 T6763 arg1Of resuspended,in
R3551 T6765 T6763 arg2Of μl,in
R3552 T6765 T6764 arg1Of μl,80
R3553 T6765 T6766 arg1Of μl,of
R3554 T6769 T6766 arg2Of buffer,of
R3555 T6769 T6767 arg1Of buffer,FBS
R3556 T6769 T6768 arg1Of buffer,staining
R3557 T6771 T6770 arg1Of microbeads,Anti-CD4
R3558 T6771 T6772 arg1Of microbeads,(
R3559 T6771 T6776 arg1Of microbeads,were
R356 T906 T905 arg1Of factor-β,growth
R3560 T6771 T6777 arg2Of microbeads,added
R3561 T6771 T6779 arg2Of microbeads,incubated
R3562 T6774 T6772 arg2Of μl,(
R3563 T6774 T6773 arg1Of μl,20
R3564 T6775 T6772 arg3Of ),(
R3565 T6777 T6778 arg1Of added,and
R3566 T6778 T6776 arg2Of and,were
R3567 T6779 T6778 arg2Of incubated,and
R3568 T6779 T6780 arg1Of incubated,for
R3569 T6779 T6783 arg1Of incubated,at
R357 T907 T895 arg2Of did,whereas
R3570 T6782 T6780 arg2Of min,for
R3571 T6782 T6781 arg1Of min,15
R3572 T6784 T6783 arg2Of 6–12°C,at
R3573 T6786 T6785 arg1Of amounts,Saturating
R3574 T6786 T6787 arg1Of amounts,of
R3575 T6786 T6790 arg1Of amounts,were
R3576 T6786 T6791 arg2Of amounts,added
R3577 T6789 T6787 arg2Of antibodies,of
R3578 T6789 T6788 arg1Of antibodies,fluorochrome-conjugated
R3579 T6791 T6790 arg2Of added,were
R358 T907 T908 arg1Of did,not
R3580 T6791 T6792 arg1Of added,for
R3581 T6796 T6792 arg2Of min,for
R3582 T6796 T6793 arg1Of min,a
R3583 T6796 T6794 arg1Of min,further
R3584 T6796 T6795 arg1Of min,10
R3585 T6797 T6798 arg1Of Cells,were
R3586 T6797 T6799 arg2Of Cells,diluted
R3587 T6797 T6810 arg2Of Cells,resuspended
R3588 T6797 T6816 arg2Of Cells,separated
R3589 T6799 T6800 arg1Of diluted,in
R359 T909 T910 arg1Of IL-17,was
R3590 T6799 T6809 arg1Of diluted,","
R3591 T6802 T6800 arg2Of ml,in
R3592 T6802 T6801 arg1Of ml,2.5
R3593 T6802 T6803 arg1Of ml,of
R3594 T6802 T6807 arg1Of ml,","
R3595 T6802 T6808 arg2Of ml,pelleted
R3596 T6806 T6803 arg2Of buffer,of
R3597 T6806 T6804 arg1Of buffer,FBS
R3598 T6806 T6805 arg1Of buffer,staining
R3599 T6809 T6798 arg2Of ",",were
R360 T909 T912 arg2Of IL-17,detected
R3600 T6809 T6817 arg1Of ",",","
R3601 T6809 T6819 arg1Of ",",on
R3602 T6810 T6811 arg1Of resuspended,in
R3603 T6810 T6814 arg1Of resuspended,and
R3604 T6813 T6811 arg2Of μl,in
R3605 T6813 T6812 arg1Of μl,500
R3606 T6814 T6809 arg2Of and,","
R3607 T6816 T6814 arg2Of separated,and
R3608 T6816 T6815 arg1Of separated,magnetically
R3609 T6819 T6818 arg1Of on,usually
R361 T912 T910 arg2Of detected,was
R3610 T6822 T6819 arg2Of magnet,on
R3611 T6822 T6820 arg1Of magnet,an
R3612 T6822 T6821 arg1Of magnet,AutoMACS
R3613 T6822 T6823 arg2Of magnet,fitted
R3614 T6823 T6824 arg1Of fitted,with
R3615 T6828 T6824 arg2Of column,with
R3616 T6828 T6825 arg1Of column,a
R3617 T6828 T6826 arg1Of column,MACS
R3618 T6828 T6827 arg1Of column,MS
R3619 T6829 T6830 arg1Of Flow-through,and
R362 T912 T911 arg1Of detected,also
R3620 T6831 T6830 arg2Of two,and
R3621 T6832 T6829 arg1Of 1,Flow-through
R3622 T6832 T6831 arg1Of 1,two
R3623 T6834 T6832 arg1Of washes,1
R3624 T6834 T6833 arg1Of washes,ml
R3625 T6834 T6835 arg1Of washes,were
R3626 T6834 T6836 arg2Of washes,collected
R3627 T6836 T6835 arg2Of collected,were
R3628 T6836 T6837 arg1Of collected,as
R3629 T6840 T6837 arg2Of fraction,as
R363 T912 T913 arg1Of detected,in
R3630 T6840 T6838 arg1Of fraction,the
R3631 T6840 T6839 arg1Of fraction,negative
R3632 T6842 T6841 arg2Of cells,Enriched
R3633 T6842 T6843 arg1Of cells,were
R3634 T6842 T6844 arg2Of cells,collected
R3635 T6844 T6843 arg2Of collected,were
R3636 T6844 T6845 arg1Of collected,in
R3637 T6847 T6846 arg1Of 0.5,two
R3638 T6849 T6845 arg2Of aliquots,in
R3639 T6849 T6847 arg1Of aliquots,0.5
R364 T912 T921 arg1Of detected,but
R3640 T6849 T6848 arg1Of aliquots,ml
R3641 T6849 T6850 arg1Of aliquots,from
R3642 T6852 T6850 arg2Of column,from
R3643 T6852 T6851 arg1Of column,the
R3644 T6852 T6853 arg1Of column,after
R3645 T6854 T6853 arg2Of removal,after
R3646 T6854 T6855 arg1Of removal,from
R3647 T6857 T6855 arg2Of magnet,from
R3648 T6857 T6856 arg1Of magnet,the
R3649 T6860 T6861 arg2Of cells,stained
R365 T915 T913 arg2Of PBMC,in
R3650 T6860 T6864 arg1Of cells,were
R3651 T6860 T6865 arg2Of cells,washed
R3652 T6861 T6862 arg1Of stained,with
R3653 T6863 T6862 arg2Of anti-CD4–phycoerythrin,with
R3654 T6865 T6858 arg1Of washed,Alternatively
R3655 T6865 T6859 arg1Of washed,","
R3656 T6865 T6864 arg2Of washed,were
R3657 T6865 T6866 arg1Of washed,","
R3658 T6867 T6865 arg3Of magnetically,washed
R3659 T6867 T6868 arg2Of magnetically,labeled
R366 T915 T914 arg1Of PBMC,the
R3660 T6867 T6891 arg2Of magnetically,separated
R3661 T6868 T6869 arg1Of labeled,with
R3662 T6868 T6889 arg1Of labeled,and
R3663 T6871 T6869 arg2Of microbeads,with
R3664 T6871 T6870 arg1Of microbeads,anti-phycoerythrin
R3665 T6871 T6872 arg1Of microbeads,(
R3666 T6874 T6873 arg1Of μl,20
R3667 T6874 T6875 arg1Of μl,added
R3668 T6875 T6872 arg2Of added,(
R3669 T6875 T6876 arg1Of added,to
R367 T915 T916 arg1Of PBMC,of
R3670 T6878 T6877 arg1Of μl,80
R3671 T6878 T6879 arg1Of μl,of
R3672 T6878 T6882 arg1Of μl,;
R3673 T6881 T6879 arg2Of suspension,of
R3674 T6881 T6880 arg1Of suspension,cell
R3675 T6882 T6876 arg2Of ;,to
R3676 T6884 T6882 arg2Of min,;
R3677 T6884 T6883 arg1Of min,15
R3678 T6884 T6885 arg1Of min,","
R3679 T6886 T6885 arg2Of 6–12°C,","
R368 T917 T916 arg2Of patients,of
R3680 T6887 T6872 arg3Of ),(
R3681 T6889 T6888 arg1Of and,","
R3682 T6891 T6889 arg2Of separated,and
R3683 T6891 T6890 arg1Of separated,magnetically
R3684 T6891 T6892 arg1Of separated,as
R3685 T6893 T6892 arg2Of described,as
R3686 T6893 T6894 arg1Of described,above
R3687 T6896 T6895 arg1Of purity,The
R3688 T6896 T6897 arg1Of purity,of
R3689 T6896 T6899 arg1Of purity,was
R369 T917 T918 arg1Of patients,with
R3690 T6896 T6900 arg2Of purity,assessed
R3691 T6898 T6897 arg2Of cells,of
R3692 T6900 T6899 arg2Of assessed,was
R3693 T6904 T6900 arg1Of analysis,assessed
R3694 T6904 T6901 arg2Of analysis,by
R3695 T6904 T6902 arg1Of analysis,flow
R3696 T6904 T6903 arg1Of analysis,cytometric
R3697 T6904 T6905 arg1Of analysis,of
R3698 T6907 T6905 arg2Of cells,of
R3699 T6907 T6906 arg2Of cells,stained
R370 T919 T918 arg2Of osteoarthritis,with
R3700 T6907 T6908 arg1Of cells,on
R3701 T6911 T6910 arg1Of Vantage,FACS
R3702 T6912 T6908 arg2Of sorter,on
R3703 T6912 T6909 arg1Of sorter,a
R3704 T6912 T6911 arg1Of sorter,Vantage
R3705 T6915 T6916 arg1Of more,than
R3706 T6917 T6916 arg2Of 97,than
R3707 T6918 T6913 arg1Of %,Most
R3708 T6918 T6914 arg2Of %,(
R3709 T6918 T6915 arg1Of %,more
R371 T921 T920 arg1Of but,","
R3710 T6918 T6920 arg1Of %,of
R3711 T6918 T6924 arg1Of %,had
R3712 T6919 T6914 arg3Of ),(
R3713 T6923 T6920 arg2Of cells,of
R3714 T6923 T6921 arg1Of cells,the
R3715 T6923 T6922 arg2Of cells,isolated
R3716 T6929 T6924 arg2Of marker,had
R3717 T6929 T6925 arg1Of marker,the
R3718 T6929 T6926 arg1Of marker,CD4
R3719 T6929 T6927 arg1Of marker,T
R372 T924 T922 arg1Of levels,their
R3720 T6929 T6928 arg1Of marker,cell
R373 T924 T923 arg1Of levels,expression
R374 T924 T925 arg1Of levels,were
R375 T924 T927 arg1Of levels,lower
R376 T925 T921 arg2Of were,but
R377 T927 T925 arg2Of lower,were
R378 T927 T926 arg1Of lower,much
R379 T927 T928 arg1Of lower,than
R380 T929 T928 arg2Of those,than
R381 T929 T930 arg1Of those,of
R382 T932 T930 arg2Of PBMC,of
R383 T932 T931 arg1Of PBMC,RA
R384 T934 T933 arg1Of antibody,Anti-CD3
R385 T934 T935 arg1Of antibody,activated
R386 T935 T939 arg1Of activated,;
R387 T938 T935 arg2Of pathway,activated
R388 T938 T936 arg1Of pathway,the
R389 T938 T937 arg1Of pathway,PI3K/Akt
R390 T940 T941 arg1Of activation,of
R391 T940 T944 arg1Of activation,resulted
R392 T943 T941 arg2Of pathway,of
R393 T943 T942 arg1Of pathway,this
R3930 T7512 T7510 arg1Of assay,Enzyme-linked
R3931 T7512 T7511 arg1Of assay,immunosorbent
R3932 T7512 T7513 arg1Of assay,of
R3933 T7514 T7513 arg2Of IL-17,of
R3934 T7515 T7516 arg1Of IL-17,in
R3935 T7515 T7519 arg1Of IL-17,was
R3936 T7515 T7520 arg2Of IL-17,measured
R3937 T7518 T7516 arg2Of supernatants,in
R3938 T7518 T7517 arg1Of supernatants,culture
R3939 T7520 T7519 arg2Of measured,was
R394 T944 T939 arg2Of resulted,;
R3940 T7520 T7526 arg1Of measured,as
R3941 T7525 T7520 arg1Of assay,measured
R3942 T7525 T7521 arg2Of assay,by
R3943 T7525 T7522 arg1Of assay,sandwich
R3944 T7525 T7523 arg1Of assay,enzyme-linked
R3945 T7525 T7524 arg1Of assay,immunosorbent
R3946 T7527 T7526 arg2Of described,as
R3947 T7527 T7528 arg1Of described,previously
R3948 T7527 T7529 arg1Of described,[
R3949 T7530 T7529 arg2Of 20,[
R395 T944 T945 arg1Of resulted,in
R3950 T7531 T7529 arg3Of ],[
R3951 T7533 T7532 arg2Of brief,In
R3952 T7537 T7535 arg1Of plate,a
R3953 T7537 T7536 arg1Of plate,96-well
R3954 T7537 T7538 arg1Of plate,(
R3955 T7537 T7541 arg1Of plate,was
R3956 T7537 T7542 arg2Of plate,coated
R3957 T7539 T7538 arg2Of Nunc,(
R3958 T7540 T7538 arg3Of ),(
R3959 T7542 T7532 arg1Of coated,In
R396 T948 T945 arg2Of augmentation,in
R3960 T7542 T7534 arg1Of coated,","
R3961 T7542 T7541 arg2Of coated,was
R3962 T7542 T7543 arg1Of coated,with
R3963 T7547 T7543 arg2Of antibodies,with
R3964 T7547 T7544 arg1Of antibodies,4
R3965 T7547 T7545 arg1Of antibodies,μg/ml
R3966 T7547 T7546 arg1Of antibodies,monoclonal
R3967 T7547 T7548 arg1Of antibodies,against
R3968 T7549 T7548 arg2Of IL-17,against
R3969 T7549 T7550 arg1Of IL-17,(
R397 T948 T946 arg1Of augmentation,a
R3970 T7549 T7556 arg1Of IL-17,at
R3971 T7554 T7550 arg2Of Systems,(
R3972 T7554 T7551 arg1Of Systems,R
R3973 T7554 T7552 arg1Of Systems,&
R3974 T7554 T7553 arg1Of Systems,D
R3975 T7555 T7550 arg3Of ),(
R3976 T7557 T7556 arg2Of 4°C,at
R3977 T7557 T7558 arg1Of 4°C,overnight
R3978 T7560 T7559 arg2Of blocking,After
R3979 T7560 T7561 arg1Of blocking,with
R398 T948 T947 arg1Of augmentation,pronounced
R3980 T7564 T7563 arg1Of %,saline/1
R3981 T7567 T7561 arg2Of albumin,with
R3982 T7567 T7562 arg1Of albumin,phosphate-buffered
R3983 T7567 T7564 arg1Of albumin,%
R3984 T7567 T7565 arg1Of albumin,bovine
R3985 T7567 T7566 arg1Of albumin,serum
R3986 T7567 T7568 arg1Of albumin,(
R3987 T7569 T7568 arg2Of BSA,(
R3988 T7570 T7568 arg3Of ),(
R3989 T7572 T7571 arg1Of %,/0.05
R399 T948 T949 arg1Of augmentation,of
R3990 T7572 T7573 arg1Of %,Tween
R3991 T7572 T7574 arg1Of %,20
R3992 T7572 T7575 arg1Of %,for
R3993 T7572 T7578 arg1Of %,at
R3994 T7572 T7584 arg1Of %,","
R3995 T7577 T7575 arg2Of hours,for
R3996 T7577 T7576 arg1Of hours,2
R3997 T7580 T7578 arg2Of temperature,at
R3998 T7580 T7579 arg1Of temperature,room
R3999 T7580 T7581 arg1Of temperature,(
R400 T954 T953 arg2Of NF-κB,(
R4000 T7582 T7581 arg2Of 22–25°C,(
R4001 T7583 T7581 arg3Of ),(
R4002 T7585 T7584 arg2Of test,","
R4003 T7586 T7572 arg1Of samples,%
R4004 T7586 T7585 arg1Of samples,test
R4005 T7586 T7587 arg1Of samples,and
R4006 T7587 T7560 arg1Of and,blocking
R4007 T7587 T7598 arg1Of and,were
R4008 T7587 T7599 arg2Of and,added
R4009 T7587 T7605 arg2Of and,incubated
R401 T955 T953 arg3Of ),(
R4010 T7591 T7587 arg2Of IL-17,and
R4011 T7591 T7588 arg1Of IL-17,the
R4012 T7591 T7589 arg1Of IL-17,standard
R4013 T7591 T7590 arg1Of IL-17,recombinant
R4014 T7591 T7592 arg1Of IL-17,(
R4015 T7596 T7592 arg2Of Systems,(
R4016 T7596 T7593 arg1Of Systems,R
R4017 T7596 T7594 arg1Of Systems,&
R4018 T7596 T7595 arg1Of Systems,D
R4019 T7597 T7592 arg3Of ),(
R402 T957 T949 arg2Of activity,of
R4020 T7599 T7600 arg1Of added,to
R4021 T7599 T7604 arg1Of added,and
R4022 T7603 T7600 arg2Of plate,to
R4023 T7603 T7601 arg1Of plate,the
R4024 T7603 T7602 arg1Of plate,96-well
R4025 T7604 T7559 arg1Of and,After
R4026 T7604 T7598 arg2Of and,were
R4027 T7605 T7604 arg2Of incubated,and
R4028 T7605 T7606 arg1Of incubated,at
R4029 T7605 T7609 arg1Of incubated,for
R403 T957 T950 arg1Of activity,nuclear
R4030 T7608 T7606 arg2Of temperature,at
R4031 T7608 T7607 arg1Of temperature,room
R4032 T7611 T7609 arg2Of hours,for
R4033 T7611 T7610 arg1Of hours,2
R4034 T7612 T7613 arg1Of Plates,were
R4035 T7612 T7614 arg2Of Plates,washed
R4036 T7612 T7624 arg2Of Plates,incubated
R4037 T7614 T7616 arg1Of washed,times
R4038 T7614 T7622 arg1Of washed,and
R4039 T7616 T7615 arg1Of times,four
R404 T957 T951 arg1Of activity,factor
R4040 T7616 T7617 arg1Of times,with
R4041 T7619 T7617 arg2Of saline/Tween,with
R4042 T7619 T7618 arg1Of saline/Tween,phosphate-buffered
R4043 T7619 T7620 arg1Of saline/Tween,20
R4044 T7622 T7613 arg2Of and,were
R4045 T7622 T7621 arg1Of and,","
R4046 T7624 T7622 arg2Of incubated,and
R4047 T7624 T7623 arg1Of incubated,then
R4048 T7624 T7625 arg1Of incubated,with
R4049 T7627 T7625 arg2Of ng/ml,with
R405 T957 T952 arg1Of activity,κB
R4050 T7627 T7626 arg1Of ng/ml,500
R4051 T7627 T7628 arg2Of ng/ml,biotinylated
R4052 T7628 T7640 arg1Of biotinylated,for
R4053 T7631 T7628 arg3Of antibodies,biotinylated
R4054 T7631 T7629 arg1Of antibodies,mouse
R4055 T7631 T7630 arg1Of antibodies,monoclonal
R4056 T7631 T7632 arg1Of antibodies,against
R4057 T7631 T7634 arg1Of antibodies,(
R4058 T7633 T7632 arg2Of IL-17,against
R4059 T7638 T7634 arg2Of Systems,(
R406 T957 T953 arg1Of activity,(
R4060 T7638 T7635 arg1Of Systems,R
R4061 T7638 T7636 arg1Of Systems,&
R4062 T7638 T7637 arg1Of Systems,D
R4063 T7639 T7634 arg3Of ),(
R4064 T7642 T7640 arg2Of hours,for
R4065 T7642 T7641 arg1Of hours,2
R4066 T7642 T7643 arg1Of hours,at
R4067 T7645 T7643 arg2Of temperature,at
R4068 T7645 T7644 arg1Of temperature,room
R4069 T7647 T7646 arg2Of washing,After
R407 T957 T956 arg1Of activity,DNA-binding
R4070 T7652 T7649 arg1Of conjugate,streptavidin–alkaline
R4071 T7652 T7650 arg1Of conjugate,phosphate–horseradish
R4072 T7652 T7651 arg1Of conjugate,peroxidase
R4073 T7652 T7653 arg1Of conjugate,(
R4074 T7652 T7656 arg1Of conjugate,was
R4075 T7652 T7657 arg2Of conjugate,incubated
R4076 T7652 T7663 arg1Of conjugate,washed
R4077 T7652 T7666 arg2Of conjugate,incubated
R4078 T7654 T7653 arg2Of Sigma,(
R4079 T7655 T7653 arg3Of ),(
R408 T959 T958 arg1Of production,IL-17
R4080 T7657 T7656 arg2Of incubated,was
R4081 T7657 T7658 arg1Of incubated,for
R4082 T7657 T7661 arg1Of incubated,","
R4083 T7660 T7658 arg2Of hours,for
R4084 T7660 T7659 arg1Of hours,2
R4085 T7661 T7665 arg1Of ",",and
R4086 T7663 T7661 arg2Of washed,","
R4087 T7663 T7662 arg1Of washed,then
R4088 T7663 T7664 arg1Of washed,again
R4089 T7665 T7647 arg2Of and,washing
R409 T959 T960 arg1Of production,by
R4090 T7665 T7648 arg1Of and,","
R4091 T7666 T7665 arg2Of incubated,and
R4092 T7666 T7667 arg1Of incubated,with
R4093 T7669 T7667 arg2Of mg/ml,with
R4094 T7669 T7668 arg1Of mg/ml,1
R4095 T7671 T7647 arg1Of phosphate,washing
R4096 T7671 T7670 arg1Of phosphate,p-nitrophenyl
R4097 T7671 T7672 arg1Of phosphate,(
R4098 T7671 T7675 arg2Of phosphate,dissolved
R4099 T7673 T7672 arg2Of Sigma,(
R410 T959 T964 arg1Of production,is
R4100 T7674 T7672 arg3Of ),(
R4101 T7675 T7646 arg1Of dissolved,After
R4102 T7675 T7676 arg1Of dissolved,in
R4103 T7675 T7681 modOf dissolved,to
R4104 T7677 T7676 arg2Of diethanolamine,in
R4105 T7677 T7678 arg1Of diethanolamine,(
R4106 T7679 T7678 arg2Of Sigma,(
R4107 T7680 T7678 arg3Of ),(
R4108 T7682 T7681 arg1Of develop,to
R4109 T7685 T7682 arg2Of reaction,develop
R411 T959 T968 arg2Of production,blocked
R4110 T7685 T7683 arg1Of reaction,the
R4111 T7685 T7684 arg1Of reaction,color
R4112 T7687 T7686 arg1Of reaction,The
R4113 T7687 T7688 arg1Of reaction,was
R4114 T7687 T7689 arg2Of reaction,stopped
R4115 T7689 T7688 arg2Of stopped,was
R4116 T7689 T7690 arg1Of stopped,by
R4117 T7689 T7697 arg1Of stopped,and
R4118 T7692 T7690 arg2Of addition,by
R4119 T7692 T7691 arg1Of addition,the
R412 T963 T960 arg2Of PBMC,by
R4120 T7692 T7693 arg1Of addition,of
R4121 T7694 T7695 arg1Of 1,M
R4122 T7696 T7693 arg2Of NaOH,of
R4123 T7696 T7694 arg1Of NaOH,1
R4124 T7700 T7698 arg1Of density,the
R4125 T7700 T7699 arg1Of density,optical
R4126 T7700 T7701 arg1Of density,of
R4127 T7700 T7704 arg1Of density,was
R4128 T7700 T7705 arg2Of density,read
R4129 T7703 T7701 arg2Of well,of
R413 T963 T961 arg2Of PBMC,activated
R4130 T7703 T7702 arg1Of well,each
R4131 T7705 T7697 arg2Of read,and
R4132 T7705 T7704 arg2Of read,was
R4133 T7705 T7706 arg1Of read,at
R4134 T7708 T7706 arg2Of nm,at
R4135 T7708 T7707 arg1Of nm,405
R4136 T7711 T7709 arg1Of limit,The
R4137 T7711 T7710 arg1Of limit,lower
R4138 T7711 T7712 arg1Of limit,of
R4139 T7711 T7715 arg1Of limit,was
R414 T963 T962 arg1Of PBMC,RA
R4140 T7714 T7712 arg2Of detection,of
R4141 T7714 T7713 arg1Of detection,IL-17
R4142 T7717 T7715 arg2Of pg/ml,was
R4143 T7717 T7716 arg1Of pg/ml,10
R4144 T7720 T7718 arg1Of IL-17,Recombinant
R4145 T7720 T7719 arg1Of IL-17,human
R4146 T7720 T7721 arg2Of IL-17,diluted
R4147 T7720 T7725 arg1Of IL-17,was
R4148 T7720 T7726 arg2Of IL-17,used
R4149 T7720 T7732 arg1Of IL-17,ranging
R415 T965 T966 arg1Of completely,or
R4150 T7721 T7722 arg1Of diluted,in
R4151 T7724 T7722 arg2Of medium,in
R4152 T7724 T7723 arg1Of medium,culture
R4153 T7726 T7725 arg2Of used,was
R4154 T7726 T7727 arg1Of used,as
R4155 T7726 T7731 arg1Of used,","
R4156 T7726 T7732 modOf used,ranging
R4157 T7730 T7727 arg2Of standard,as
R4158 T7730 T7728 arg1Of standard,a
R4159 T7730 T7729 arg1Of standard,calibration
R416 T967 T966 arg2Of partly,or
R4160 T7732 T7733 arg1Of ranging,from
R4161 T7734 T7733 arg2Of 10,from
R4162 T7737 T7732 arg2Of pg/ml,ranging
R4163 T7737 T7735 arg1Of pg/ml,to
R4164 T7737 T7736 arg1Of pg/ml,2000
R4165 T7740 T7738 arg1Of curve,A
R4166 T7740 T7739 arg1Of curve,standard
R4167 T7740 T7741 arg1Of curve,was
R4168 T7740 T7742 arg2Of curve,drawn
R4169 T7740 T7758 arg2Of curve,used
R417 T968 T964 arg2Of blocked,is
R4170 T7742 T7743 arg1Of drawn,by
R4171 T7742 T7757 arg1Of drawn,and
R4172 T7744 T7743 arg2Of plotting,by
R4173 T7746 T7744 arg2Of density,plotting
R4174 T7746 T7745 arg1Of density,optical
R4175 T7746 T7747 arg1Of density,against
R4176 T7749 T7747 arg2Of log,against
R4177 T7749 T7748 arg1Of log,the
R4178 T7749 T7750 arg1Of log,of
R4179 T7752 T7750 arg2Of concentration,of
R418 T968 T965 arg1Of blocked,completely
R4180 T7752 T7751 arg1Of concentration,the
R4181 T7752 T7753 arg1Of concentration,of
R4182 T7755 T7753 arg2Of cytokines,of
R4183 T7755 T7754 arg1Of cytokines,recombinant
R4184 T7757 T7741 arg2Of and,was
R4185 T7757 T7756 arg1Of and,","
R4186 T7758 T7757 arg2Of used,and
R4187 T7758 T7759 arg1Of used,for
R4188 T7760 T7759 arg2Of determination,for
R4189 T7760 T7761 arg1Of determination,of
R419 T968 T967 arg1Of blocked,partly
R4190 T7760 T7763 arg1Of determination,in
R4191 T7762 T7761 arg2Of IL-17,of
R4192 T7765 T7763 arg2Of samples,in
R4193 T7765 T7764 arg1Of samples,test
R420 T968 T969 arg1Of blocked,in
R421 T968 T985 arg1Of blocked,","
R422 T968 T986 arg1Of blocked,respectively
R423 T971 T970 arg1Of presence,the
R424 T971 T972 arg1Of presence,of
R425 T971 T978 arg1Of presence,and
R426 T977 T972 arg2Of dithiocarbamate,of
R427 T977 T973 arg1Of dithiocarbamate,the
R428 T977 T974 arg1Of dithiocarbamate,NF-κB
R429 T977 T975 arg1Of dithiocarbamate,inhibitor
R430 T977 T976 arg1Of dithiocarbamate,pyrrolidine
R431 T978 T969 arg2Of and,in
R432 T982 T983 arg1Of wortmannin,and
R433 T983 T978 arg2Of and,and
R434 T983 T979 arg1Of and,the
R435 T983 T980 arg1Of and,PI3K/Akt
R436 T983 T981 arg1Of and,inhibitor
R437 T984 T983 arg2Of LY294002,and
R438 T989 T990 arg1Of inhibition,of
R439 T989 T993 arg1Of inhibition,and
R440 T992 T990 arg2Of protein-1,of
R441 T992 T991 arg1Of protein-1,activator
R442 T993 T998 arg1Of and,did
R443 T993 T1000 arg1Of and,affect
R444 T996 T993 arg2Of kinase,and
R445 T996 T994 arg1Of kinase,extracellular
R446 T996 T995 arg1Of kinase,signal-regulated
R447 T996 T997 arg1Of kinase,1/2
R448 T1000 T987 arg1Of affect,However
R449 T1000 T988 arg1Of affect,","
R450 T1000 T998 arg2Of affect,did
R451 T1000 T999 arg1Of affect,not
R452 T1002 T1000 arg2Of production,affect
R453 T1002 T1001 arg1Of production,IL-17
R454 T1004 T1003 arg1Of results,These
R455 T1004 T1005 arg1Of results,suggest
R456 T1009 T1007 arg1Of pathways,signal
R457 T1009 T1008 arg1Of pathways,transduction
R458 T1009 T1010 arg1Of pathways,dependent
R459 T1009 T1015 arg1Of pathways,are
R460 T1009 T1016 arg2Of pathways,involved
R461 T1010 T1011 arg1Of dependent,on
R462 T1012 T1013 arg1Of PI3K/Akt,and
R463 T1013 T1011 arg2Of and,on
R464 T1014 T1013 arg2Of NF-κB,and
R465 T1016 T1005 arg2Of involved,suggest
R466 T1016 T1006 arg1Of involved,that
R467 T1016 T1015 arg2Of involved,are
R468 T1016 T1017 arg1Of involved,in
R469 T1019 T1017 arg2Of overproduction,in
R470 T1019 T1018 arg1Of overproduction,the
R471 T1019 T1020 arg1Of overproduction,of
R472 T1025 T1020 arg2Of IL-17,of
R473 T1025 T1021 arg1Of IL-17,the
R474 T1025 T1022 arg1Of IL-17,key
R475 T1025 T1023 arg1Of IL-17,inflammatory
R476 T1025 T1024 arg1Of IL-17,cytokine
R477 T1025 T1026 arg1Of IL-17,in
R478 T1027 T1026 arg2Of RA,in
R4834 T9383 T9381 arg1Of analysis,Western
R4835 T9383 T9382 arg1Of analysis,blot
R4836 T9383 T9384 arg1Of analysis,of
R4837 T9385 T9386 arg1Of Akt,","
R4838 T9386 T9389 arg1Of ",",and
R4839 T9388 T9386 arg2Of Akt,","
R4840 T9388 T9387 arg2Of Akt,phosphorylated
R4841 T9389 T9384 arg2Of and,of
R4842 T9390 T9389 arg2Of IκB-α,and
R4843 T9391 T9392 arg1Of PBMC,were
R4844 T9391 T9393 arg2Of PBMC,incubated
R4845 T9393 T9392 arg2Of incubated,were
R4846 T9393 T9394 arg1Of incubated,with
R4847 T9393 T9400 arg1Of incubated,in
R4848 T9395 T9394 arg2Of anti-CD3,with
R4849 T9395 T9396 arg1Of anti-CD3,(
R4850 T9398 T9396 arg2Of μg/ml,(
R4851 T9398 T9397 arg1Of μg/ml,10
R4852 T9399 T9396 arg3Of ),(
R4853 T9402 T9403 arg1Of presence,or
R4854 T9403 T9400 arg2Of or,in
R4855 T9403 T9401 arg1Of or,the
R4856 T9403 T9405 arg1Of or,of
R4857 T9404 T9403 arg2Of absence,or
R4858 T9406 T9405 arg2Of LY294002,of
R4859 T9406 T9407 arg1Of LY294002,(
R4860 T9409 T9407 arg2Of μM,(
R4861 T9409 T9408 arg1Of μM,20
R4862 T9410 T9407 arg3Of ),(
R4863 T9412 T9411 arg2Of incubation,After
R4864 T9412 T9413 arg1Of incubation,for
R4865 T9415 T9413 arg2Of hour,for
R4866 T9415 T9414 arg1Of hour,1
R4867 T9419 T9417 arg1Of lysates,whole
R4868 T9419 T9418 arg1Of lysates,cell
R4869 T9419 T9420 arg1Of lysates,were
R4870 T9419 T9421 arg2Of lysates,prepared
R4871 T9419 T9434 arg2Of lysates,centrifuged
R4872 T9421 T9422 arg1Of prepared,from
R4873 T9421 T9433 arg1Of prepared,and
R4874 T9424 T9423 arg1Of 107,about
R4875 T9425 T9422 arg2Of cells,from
R4876 T9425 T9424 arg1Of cells,107
R4877 T9427 T9421 arg1Of homogenization,prepared
R4878 T9427 T9426 arg2Of homogenization,by
R4879 T9427 T9428 arg1Of homogenization,in
R4880 T9431 T9428 arg2Of buffer,in
R4881 T9431 T9429 arg1Of buffer,the
R4882 T9431 T9430 arg1Of buffer,lysis
R4883 T9433 T9411 arg1Of and,After
R4884 T9433 T9416 arg1Of and,","
R4885 T9433 T9420 arg2Of and,were
R4886 T9433 T9432 arg1Of and,","
R4887 T9434 T9433 arg2Of centrifuged,and
R4888 T9434 T9435 arg1Of centrifuged,at
R4889 T9434 T9442 arg1Of centrifuged,for
R4890 T9437 T9435 arg2Of r.p.m.,at
R4891 T9437 T9436 arg1Of r.p.m.,"14,000"
R4892 T9437 T9438 arg1Of r.p.m.,(
R4893 T9440 T9438 arg2Of g,(
R4894 T9440 T9439 arg1Of g,"19,000"
R4895 T9441 T9438 arg3Of ),(
R4896 T9444 T9442 arg2Of min,for
R4897 T9444 T9443 arg1Of min,15
R4898 T9446 T9445 arg1Of concentrations,Protein
R4899 T9446 T9447 arg1Of concentrations,in
R4900 T9446 T9450 arg1Of concentrations,were
R4901 T9446 T9451 arg2Of concentrations,determined
R4902 T9449 T9447 arg2Of supernatants,in
R4903 T9449 T9448 arg1Of supernatants,the
R4904 T9451 T9450 arg2Of determined,were
R4905 T9451 T9452 arg1Of determined,with
R4906 T9451 T9456 arg1Of determined,(
R4907 T9455 T9452 arg2Of method,with
R4908 T9455 T9453 arg1Of method,the
R4909 T9455 T9454 arg1Of method,Bradford
R4910 T9457 T9458 arg1Of Bio-Rad,","
R4911 T9458 T9460 arg1Of ",",","
R4912 T9459 T9458 arg2Of Hercules,","
R4913 T9460 T9456 arg2Of ",",(
R4914 T9460 T9462 arg1Of ",",","
R4915 T9460 T9463 arg1Of ",",USA
R4916 T9461 T9460 arg2Of CA,","
R4917 T9464 T9456 arg3Of ),(
R4918 T9466 T9465 arg1Of samples,Protein
R4919 T9466 T9467 arg1Of samples,were
R4920 T9466 T9468 arg2Of samples,separated
R4921 T9466 T9474 arg2Of samples,transferred
R4922 T9468 T9473 arg1Of separated,and
R4923 T9470 T9471 arg1Of 10,%
R4924 T9472 T9468 arg1Of SDS–PAGE,separated
R4925 T9472 T9469 arg2Of SDS–PAGE,by
R4926 T9472 T9470 arg1Of SDS–PAGE,10
R4927 T9473 T9467 arg2Of and,were
R4928 T9473 T9479 arg1Of and,(
R4929 T9474 T9473 arg2Of transferred,and
R4930 T9474 T9475 arg1Of transferred,to
R4931 T9478 T9475 arg2Of membrane,to
R4932 T9478 T9476 arg1Of membrane,a
R4933 T9478 T9477 arg1Of membrane,nitrocellulose
R4934 T9482 T9479 arg2Of Biotech,(
R4935 T9482 T9480 arg1Of Biotech,Amersham
R4936 T9482 T9481 arg1Of Biotech,Pharmacia
R4937 T9482 T9483 arg1Of Biotech,","
R4938 T9484 T9483 arg2Of Uppsala,","
R4939 T9484 T9485 arg1Of Uppsala,","
R4940 T9486 T9485 arg2Of Sweden,","
R4941 T9487 T9479 arg3Of ),(
R4942 T9490 T9488 arg2Of hybridization,For
R4943 T9490 T9489 arg1Of hybridization,western
R4944 T9492 T9493 arg1Of membrane,was
R4945 T9492 T9494 arg2Of membrane,preincubated
R4946 T9494 T9493 arg2Of preincubated,was
R4947 T9494 T9495 arg1Of preincubated,with
R4948 T9494 T9515 arg1Of preincubated,for
R4949 T9494 T9524 arg1Of preincubated,","
R4950 T9497 T9496 arg1Of %,0.1
R4951 T9499 T9495 arg2Of milk,with
R4952 T9499 T9497 arg1Of milk,%
R4953 T9499 T9498 arg2Of milk,skimmed
R4954 T9499 T9500 arg1Of milk,in
R4955 T9502 T9500 arg2Of buffer,in
R4956 T9502 T9501 arg1Of buffer,TBS-T
R4957 T9502 T9503 arg1Of buffer,(
R4958 T9502 T9512 arg1Of buffer,at
R4959 T9505 T9504 arg1Of %,0.1
R4960 T9507 T9503 arg2Of 20,(
R4961 T9507 T9505 arg1Of 20,%
R4962 T9507 T9506 arg1Of 20,Tween
R4963 T9507 T9508 arg1Of 20,in
R4964 T9510 T9508 arg2Of saline,in
R4965 T9510 T9509 arg1Of saline,Tris-buffered
R4966 T9511 T9503 arg3Of ),(
R4967 T9514 T9512 arg2Of temperature,at
R4968 T9514 T9513 arg1Of temperature,room
R4969 T9517 T9515 arg2Of hours,for
R4970 T9517 T9516 arg1Of hours,2
R4971 T9517 T9518 arg1Of hours,","
R4972 T9521 T9518 arg2Of antibodies,","
R4973 T9521 T9519 arg1Of antibodies,then
R4974 T9521 T9520 arg1Of antibodies,primary
R4975 T9521 T9522 arg1Of antibodies,against
R4976 T9523 T9522 arg2Of Akt,against
R4977 T9524 T9488 arg1Of ",",For
R4978 T9524 T9491 arg1Of ",",","
R4979 T9524 T9544 arg1Of ",",:
R4980 T9526 T9527 arg1Of Akt,and
R4981 T9527 T9525 arg2Of and,phosphorylated
R4982 T9527 T9529 arg1Of and,(
R4983 T9527 T9542 arg1Of and,diluted
R4984 T9528 T9527 arg2Of IκB-α,and
R4985 T9533 T9529 arg2Of Inc.,(
R4986 T9533 T9530 arg1Of Inc.,Cell
R4987 T9533 T9531 arg1Of Inc.,Signaling
R4988 T9533 T9532 arg1Of Inc.,Technology
R4989 T9533 T9534 arg1Of Inc.,","
R4990 T9533 T9538 arg1Of Inc.,","
R4991 T9533 T9539 arg1Of Inc.,USA
R4992 T9535 T9536 arg1Of Beverly,","
R4993 T9536 T9534 arg2Of ",",","
R4994 T9537 T9536 arg2Of MA,","
R4995 T9540 T9529 arg3Of ),(
R4996 T9542 T9524 arg2Of diluted,","
R4997 T9542 T9541 arg1Of diluted,","
R4998 T9543 T9542 arg2Of 1,diluted
R4999 T9545 T9546 arg1Of 1000,in
R5000 T9545 T9551 arg1Of 1000,were
R5001 T9545 T9552 arg2Of 1000,added
R5002 T9545 T9554 arg2Of 1000,incubated
R5003 T9547 T9548 arg1Of 5,%
R5004 T9549 T9546 arg2Of BSA/TBS-T,in
R5005 T9549 T9547 arg1Of BSA/TBS-T,5
R5006 T9552 T9553 arg1Of added,and
R5007 T9553 T9544 arg2Of and,:
R5008 T9553 T9550 arg1Of and,","
R5009 T9553 T9551 arg2Of and,were
R5010 T9553 T9556 arg1Of and,at
R5011 T9554 T9553 arg2Of incubated,and
R5012 T9554 T9555 arg1Of incubated,overnight
R5013 T9557 T9556 arg2Of 4°C,at
R5014 T9559 T9558 arg2Of washing,After
R5015 T9559 T9562 arg1Of washing,with
R5016 T9561 T9559 arg2Of times,washing
R5017 T9561 T9560 arg1Of times,four
R5018 T9563 T9562 arg2Of TBS-T,with
R5019 T9568 T9559 arg1Of antibodies,washing
R5020 T9568 T9565 arg1Of antibodies,horseradish
R5021 T9568 T9566 arg1Of antibodies,peroxidase-conjugated
R5022 T9568 T9567 arg1Of antibodies,secondary
R5023 T9568 T9569 arg1Of antibodies,were
R5024 T9568 T9570 arg2Of antibodies,added
R5025 T9568 T9572 arg2Of antibodies,allowed
R5026 T9568 T9574 arg1Of antibodies,incubate
R5027 T9570 T9571 arg1Of added,and
R5028 T9571 T9558 arg1Of and,After
R5029 T9571 T9564 arg1Of and,","
R5030 T9571 T9569 arg2Of and,were
R5031 T9572 T9571 arg2Of allowed,and
R5032 T9574 T9572 arg3Of incubate,allowed
R5033 T9574 T9573 arg1Of incubate,to
R5034 T9574 T9575 arg1Of incubate,for
R5035 T9574 T9578 arg1Of incubate,at
R5036 T9577 T9575 arg2Of hour,for
R5037 T9577 T9576 arg1Of hour,1
R5038 T9580 T9578 arg2Of temperature,at
R5039 T9580 T9579 arg1Of temperature,room
R5040 T9583 T9581 arg2Of washing,After
R5041 T9583 T9582 arg1Of washing,TBS-T
R5042 T9586 T9585 arg2Of bands,hybridized
R5043 T9586 T9587 arg1Of bands,were
R5044 T9586 T9588 arg2Of bands,detected
R5045 T9588 T9581 arg1Of detected,After
R5046 T9588 T9584 arg1Of detected,","
R5047 T9588 T9587 arg2Of detected,were
R5048 T9588 T9589 arg1Of detected,with
R5049 T9594 T9593 arg2Of ECL,(
R5050 T9595 T9593 arg3Of ),(
R5051 T9597 T9592 arg1Of kit,chemiluminescence
R5052 T9597 T9593 arg1Of kit,(
R5053 T9597 T9596 arg1Of kit,detection
R5054 T9597 T9598 arg1Of kit,and
R5055 T9598 T9589 arg2Of and,with
R5056 T9598 T9590 arg1Of and,the
R5057 T9598 T9591 arg2Of and,enhanced
R5058 T9600 T9598 arg2Of reagents,and
R5059 T9600 T9599 arg1Of reagents,Hyperfilm-ECL
R5060 T9600 T9601 arg1Of reagents,(
R5061 T9603 T9601 arg2Of Pharmacia,(
R5062 T9603 T9602 arg1Of Pharmacia,Amersham
R5063 T9604 T9601 arg3Of ),(
R5322 T10192 T10190 arg1Of assay,Gel
R5323 T10192 T10191 arg1Of assay,mobility-shift
R5324 T10192 T10193 arg1Of assay,of
R5325 T10196 T10193 arg2Of site,of
R5326 T10196 T10194 arg1Of site,NF-κB
R5327 T10196 T10195 arg1Of site,binding
R5328 T10198 T10197 arg1Of proteins,Nuclear
R5329 T10198 T10199 arg1Of proteins,were
R5330 T10198 T10200 arg2Of proteins,extracted
R5331 T10200 T10199 arg2Of extracted,were
R5332 T10200 T10201 arg1Of extracted,from
R5333 T10203 T10202 arg1Of 5,about
R5334 T10205 T10204 arg1Of 106,×
R5335 T10206 T10201 arg2Of PBMC,from
R5336 T10206 T10203 arg1Of PBMC,5
R5337 T10206 T10205 arg1Of PBMC,106
R5338 T10208 T10207 arg1Of probes,Oligonucleotide
R5339 T10208 T10209 arg1Of probes,encompassing
R5340 T10208 T10230 arg1Of probes,were
R5341 T10208 T10231 arg2Of probes,generated
R5342 T10213 T10209 arg2Of site,encompassing
R5343 T10213 T10210 arg1Of site,the
R5344 T10213 T10211 arg1Of site,NF-κB
R5345 T10213 T10212 arg1Of site,binding
R5346 T10213 T10214 arg1Of site,of
R5347 T10218 T10214 arg2Of promoter,of
R5348 T10218 T10215 arg1Of promoter,the
R5349 T10218 T10216 arg1Of promoter,human
R5350 T10218 T10217 arg1Of promoter,IL-17
R5351 T10218 T10219 arg1Of promoter,(
R5352 T10227 T10219 arg2Of TTC-3,(
R5353 T10227 T10220 arg1Of TTC-3,5'-ATG
R5354 T10227 T10221 arg1Of TTC-3,ACC
R5355 T10227 T10222 arg1Of TTC-3,TGG
R5356 T10227 T10223 arg1Of TTC-3,AAA
R5357 T10227 T10224 arg1Of TTC-3,TAC
R5358 T10227 T10225 arg1Of TTC-3,CCA
R5359 T10227 T10226 arg1Of TTC-3,AAA
R5360 T10227 T10228 arg1Of TTC-3,'
R5361 T10229 T10219 arg3Of ),(
R5362 T10231 T10230 arg2Of generated,were
R5363 T10231 T10232 arg1Of generated,by
R5364 T10231 T10239 arg1Of generated,with
R5365 T10234 T10232 arg2Of labeling,by
R5366 T10234 T10233 arg1Of labeling,5'-end
R5367 T10234 T10235 arg1Of labeling,of
R5368 T10238 T10235 arg2Of strand,of
R5369 T10238 T10236 arg1Of strand,the
R5370 T10238 T10237 arg1Of strand,sense
R5371 T10241 T10240 arg2Of γ-32P,[
R5372 T10242 T10240 arg3Of ],[
R5373 T10243 T10240 arg1Of dATP,[
R5374 T10243 T10244 arg1Of dATP,(
R5375 T10243 T10248 arg1Of dATP,and
R5376 T10246 T10244 arg2Of Pharmacia,(
R5377 T10246 T10245 arg1Of Pharmacia,Amersham
R5378 T10247 T10244 arg3Of ),(
R5379 T10248 T10239 arg2Of and,with
R5380 T10251 T10248 arg2Of kinase,and
R5381 T10251 T10249 arg1Of kinase,T4
R5382 T10251 T10250 arg1Of kinase,polynucleotide
R5383 T10251 T10252 arg1Of kinase,(
R5384 T10253 T10252 arg2Of TaKaRa,(
R5385 T10254 T10252 arg3Of ),(
R5386 T10256 T10255 arg1Of nucleotides,Unincorporated
R5387 T10256 T10257 arg1Of nucleotides,were
R5388 T10256 T10258 arg2Of nucleotides,removed
R5389 T10258 T10257 arg2Of removed,were
R5390 T10263 T10258 arg1Of columns,removed
R5391 T10263 T10259 arg2Of columns,by
R5392 T10263 T10260 arg1Of columns,NucTrap
R5393 T10263 T10261 arg1Of columns,probe
R5394 T10263 T10262 arg1Of columns,purification
R5395 T10263 T10264 arg1Of columns,(
R5396 T10265 T10266 arg1Of Stratagene,","
R5397 T10266 T10269 arg1Of ",",","
R5398 T10268 T10266 arg2Of Jolla,","
R5399 T10268 T10267 arg1Of Jolla,La
R5400 T10269 T10264 arg2Of ",",(
R5401 T10269 T10271 arg1Of ",",","
R5402 T10270 T10269 arg2Of CA,","
R5403 T10272 T10271 arg2Of USA,","
R5404 T10273 T10264 arg3Of ),(
R5405 T10275 T10274 arg1Of extracts,Nuclear
R5406 T10275 T10276 arg1Of extracts,(
R5407 T10275 T10282 arg1Of extracts,were
R5408 T10275 T10283 arg2Of extracts,incubated
R5409 T10278 T10276 arg2Of μg,(
R5410 T10278 T10277 arg1Of μg,2
R5411 T10278 T10279 arg1Of μg,of
R5412 T10280 T10279 arg2Of protein,of
R5413 T10281 T10276 arg3Of ),(
R5414 T10283 T10282 arg2Of incubated,were
R5415 T10283 T10284 arg1Of incubated,with
R5416 T10283 T10295 arg1Of incubated,for
R5417 T10287 T10284 arg2Of probes,with
R5418 T10287 T10285 arg2Of probes,radiolabeled
R5419 T10287 T10286 arg1Of probes,DNA
R5420 T10287 T10288 arg1Of probes,(
R5421 T10290 T10289 arg1Of ng,10
R5422 T10290 T10291 arg1Of ng,;
R5423 T10291 T10288 arg2Of ;,(
R5424 T10293 T10291 arg2Of c.p.m.,;
R5425 T10293 T10292 arg1Of c.p.m.,"100,000"
R5426 T10294 T10288 arg3Of ),(
R5427 T10297 T10295 arg2Of min,for
R5428 T10297 T10296 arg1Of min,30
R5429 T10297 T10298 arg1Of min,at
R5430 T10297 T10301 arg1Of min,in
R5431 T10297 T10307 arg1Of min,consisting
R5432 T10297 T10323 arg1Of min,","
R5433 T10300 T10298 arg2Of temperature,at
R5434 T10300 T10299 arg1Of temperature,room
R5435 T10303 T10301 arg2Of μl,in
R5436 T10303 T10302 arg1Of μl,20
R5437 T10303 T10304 arg1Of μl,of
R5438 T10306 T10304 arg2Of buffer,of
R5439 T10306 T10305 arg1Of buffer,binding
R5440 T10307 T10308 arg1Of consisting,of
R5441 T10309 T10310 arg1Of 20,mM
R5442 T10311 T10309 arg1Of Tris-HCl,20
R5443 T10311 T10312 arg1Of Tris-HCl,","
R5444 T10312 T10315 arg1Of ",",","
R5445 T10313 T10312 arg2Of pH,","
R5446 T10313 T10314 arg1Of pH,7.9
R5447 T10315 T10319 arg1Of ",",","
R5448 T10316 T10317 arg1Of 50,mM
R5449 T10318 T10315 arg2Of KCl,","
R5450 T10318 T10316 arg1Of KCl,50
R5451 T10319 T10308 arg2Of ",",of
R5452 T10320 T10321 arg1Of 1,mM
R5453 T10322 T10319 arg2Of dithiothreitol,","
R5454 T10322 T10320 arg1Of dithiothreitol,1
R5455 T10324 T10325 arg1Of 0.5,mM
R5456 T10326 T10324 arg1Of EDTA,0.5
R5457 T10326 T10327 arg1Of EDTA,","
R5458 T10327 T10331 arg1Of ",",","
R5459 T10328 T10329 arg1Of 5,%
R5460 T10330 T10327 arg2Of glycerol,","
R5461 T10330 T10328 arg1Of glycerol,5
R5462 T10331 T10335 arg1Of ",",","
R5463 T10334 T10331 arg2Of BSA,","
R5464 T10334 T10332 arg1Of BSA,1
R5465 T10334 T10333 arg1Of BSA,mg/ml
R5466 T10335 T10340 arg1Of ",",and
R5467 T10336 T10337 arg1Of 0.2,%
R5468 T10339 T10335 arg2Of P40,","
R5469 T10339 T10336 arg1Of P40,0.2
R5470 T10339 T10338 arg1Of P40,Nonidet
R5471 T10340 T10323 arg2Of and,","
R5472 T10343 T10340 arg2Of poly,and
R5473 T10343 T10341 arg1Of poly,50
R5474 T10343 T10342 arg1Of poly,ng/μl
R5475 T10343 T10344 arg1Of poly,(
R5476 T10345 T10344 arg2Of dI-dC,(
R5477 T10346 T10344 arg3Of ),(
R5478 T10347 T10348 arg1Of Samples,were
R5479 T10347 T10349 arg2Of Samples,subjected
R5480 T10349 T10348 arg2Of subjected,were
R5481 T10349 T10350 arg1Of subjected,to
R5482 T10349 T10352 arg1Of subjected,on
R5483 T10351 T10350 arg2Of electrophoresis,to
R5484 T10354 T10355 arg1Of 5,%
R5485 T10357 T10353 arg1Of gels,nondenaturing
R5486 T10357 T10354 arg1Of gels,5
R5487 T10357 T10356 arg1Of gels,polyacrylamide
R5488 T10357 T10358 arg1Of gels,in
R5489 T10357 T10371 arg1Of gels,were
R5490 T10357 T10372 arg2Of gels,dried
R5491 T10357 T10376 arg2Of gels,exposed
R5492 T10362 T10358 arg2Of buffer,in
R5493 T10362 T10359 arg1Of buffer,0.5
R5494 T10362 T10360 arg1Of buffer,×
R5495 T10362 T10361 arg1Of buffer,Tris-borate-EDTA
R5496 T10362 T10363 arg1Of buffer,(
R5497 T10362 T10367 arg1Of buffer,at
R5498 T10364 T10363 arg2Of pH,(
R5499 T10364 T10365 arg1Of pH,8.0
R5500 T10366 T10363 arg3Of ),(
R5501 T10370 T10367 arg2Of Gels,at
R5502 T10370 T10368 arg1Of Gels,100
R5503 T10370 T10369 arg1Of Gels,V.
R5504 T10372 T10373 arg1Of dried,under
R5505 T10372 T10375 arg1Of dried,and
R5506 T10374 T10373 arg2Of vacuum,under
R5507 T10375 T10352 arg2Of and,on
R5508 T10375 T10371 arg2Of and,were
R5509 T10376 T10375 arg2Of exposed,and
R5510 T10376 T10377 modOf exposed,to
R5511 T10378 T10377 arg1Of Kodak,to
R5512 T10378 T10381 arg1Of Kodak,at
R5513 T10380 T10378 arg2Of film,Kodak
R5514 T10380 T10379 arg1Of film,X-OMAT
R5515 T10382 T10381 arg2Of -70°C,at
R5516 T10382 T10383 arg1Of -70°C,with
R5517 T10385 T10383 arg2Of screens,with
R5518 T10385 T10384 arg1Of screens,intensifying
R5519 T10388 T10386 arg1Of antibodies,Rabbit
R5520 T10388 T10387 arg1Of antibodies,polyclonal
R5521 T10388 T10389 arg1Of antibodies,against
R5522 T10388 T10397 arg1Of antibodies,were
R5523 T10388 T10398 arg1Of antibodies,from
R5524 T10391 T10390 arg1Of subunits,NF-κB
R5525 T10392 T10393 arg1Of p50,","
R5526 T10393 T10395 arg1Of ",",and
R5527 T10394 T10393 arg2Of p65,","
R5528 T10395 T10389 arg2Of and,against
R5529 T10395 T10391 arg1Of and,subunits
R5530 T10396 T10395 arg2Of c-Rel,and
R5531 T10398 T10397 arg2Of from,were
R5532 T10401 T10398 arg2Of Biotechnology,from
R5533 T10401 T10399 arg1Of Biotechnology,Santa
R5534 T10401 T10400 arg1Of Biotechnology,Cruz
R5535 T10401 T10402 arg1Of Biotechnology,(
R5536 T10404 T10402 arg2Of Cruz,(
R5537 T10404 T10403 arg1Of Cruz,Santa
R5538 T10404 T10405 arg1Of Cruz,","
R5539 T10406 T10405 arg2Of CA,","
R5540 T10406 T10407 arg1Of CA,","
R5541 T10408 T10407 arg2Of USA,","
R5542 T10409 T10402 arg3Of ),(
R5784 T10826 T10825 arg1Of viability,Cell
R5785 T10826 T10827 arg1Of viability,(
R5786 T10832 T10827 arg2Of assay,(
R5787 T10832 T10828 arg1Of assay,Trypan
R5788 T10832 T10829 arg1Of assay,blue
R5789 T10832 T10830 arg1Of assay,dye
R5790 T10832 T10831 arg1Of assay,exclusion
R5791 T10833 T10827 arg3Of ),(
R5792 T10837 T10834 arg2Of assays,For
R5793 T10837 T10835 arg1Of assays,cell
R5794 T10837 T10836 arg1Of assays,viability
R5795 T10844 T10839 arg1Of method,the
R5796 T10844 T10840 arg1Of method,trypan
R5797 T10844 T10841 arg1Of method,blue
R5798 T10844 T10842 arg1Of method,dye
R5799 T10844 T10843 arg1Of method,exclusion
R5800 T10844 T10845 arg1Of method,was
R5801 T10844 T10846 arg2Of method,used
R5802 T10846 T10834 arg1Of used,For
R5803 T10846 T10838 arg1Of used,","
R5804 T10846 T10845 arg2Of used,was
R5805 T10848 T10846 arg3Of evaluate,used
R5806 T10848 T10847 arg1Of evaluate,to
R5807 T10850 T10848 arg2Of potential,evaluate
R5808 T10850 T10849 arg1Of potential,the
R5809 T10850 T10851 arg1Of potential,of
R5810 T10854 T10851 arg2Of effect,of
R5811 T10854 T10852 arg1Of effect,direct
R5812 T10854 T10853 arg1Of effect,cytotoxic
R5813 T10854 T10855 arg1Of effect,of
R5814 T10854 T10857 arg1Of effect,on
R5815 T10856 T10855 arg2Of inhibitors,of
R5816 T10858 T10857 arg2Of cells,on
R5817 T10860 T10859 arg2Of incubation,After
R5818 T10860 T10861 arg1Of incubation,for
R5819 T10863 T10861 arg2Of hours,for
R5820 T10863 T10862 arg1Of hours,24
R5821 T10866 T10865 arg1Of cells,the
R5822 T10866 T10867 arg1Of cells,were
R5823 T10866 T10868 arg2Of cells,harvested
R5824 T10868 T10867 arg2Of harvested,were
R5825 T10868 T10869 arg1Of harvested,and
R5826 T10869 T10859 arg1Of and,After
R5827 T10869 T10864 arg1Of and,","
R5828 T10873 T10870 arg1Of viability,the
R5829 T10873 T10871 arg1Of viability,percentage
R5830 T10873 T10872 arg1Of viability,cell
R5831 T10873 T10874 arg1Of viability,was
R5832 T10873 T10875 arg2Of viability,calculated
R5833 T10875 T10869 arg2Of calculated,and
R5834 T10875 T10874 arg2Of calculated,was
R5835 T10875 T10876 arg1Of calculated,with
R5836 T10875 T10893 arg1Of calculated,[
R5837 T10880 T10876 arg2Of ×,with
R5838 T10880 T10877 arg1Of ×,the
R5839 T10880 T10878 arg1Of ×,formula
R5840 T10880 T10879 arg1Of ×,100
R5841 T10880 T10881 arg1Of ×,(
R5842 T10882 T10881 arg2Of number,(
R5843 T10882 T10883 arg1Of number,of
R5844 T10885 T10883 arg2Of cells/number,of
R5845 T10885 T10884 arg1Of cells/number,viable
R5846 T10885 T10886 arg1Of cells/number,of
R5847 T10888 T10889 arg1Of viable,and
R5848 T10889 T10887 arg1Of and,both
R5849 T10890 T10889 arg2Of dead,and
R5850 T10891 T10886 arg2Of cells,of
R5851 T10891 T10888 arg1Of cells,viable
R5852 T10891 T10890 arg1Of cells,dead
R5853 T10892 T10881 arg3Of ),(
R5854 T10894 T10893 arg2Of 21,[
R5855 T10895 T10893 arg3Of ],[
R5929 T11019 T11018 arg1Of analysis,Statistical
R5930 T11020 T11021 arg1Of Data,are
R5931 T11020 T11022 arg2Of Data,expressed
R5932 T11022 T11021 arg2Of expressed,are
R5933 T11022 T11023 arg1Of expressed,as
R5934 T11024 T11025 arg1Of means,±
R5935 T11025 T11023 arg2Of ±,as
R5936 T11026 T11025 arg2Of SEM,±
R5937 T11028 T11027 arg1Of analysis,Statistical
R5938 T11028 T11029 arg1Of analysis,was
R5939 T11028 T11030 arg2Of analysis,performed
R5940 T11030 T11029 arg2Of performed,was
R5941 T11030 T11031 arg1Of performed,with
R5942 T11032 T11033 arg2Of Student,'s
R5943 T11034 T11031 arg2Of t-test,with
R5944 T11034 T11033 arg1Of t-test,'s
R5945 T11034 T11035 arg1Of t-test,for
R5946 T11037 T11035 arg2Of pairs,for
R5947 T11037 T11036 arg1Of pairs,matched
R5948 T11039 T11038 arg1Of values,P
R5949 T11039 T11040 arg1Of values,less
R5950 T11039 T11043 arg1Of values,were
R5951 T11039 T11044 arg2Of values,considered
R5952 T11039 T11045 arg1Of values,significant
R5953 T11040 T11041 arg1Of less,than
R5954 T11042 T11041 arg2Of 0.05,than
R5955 T11044 T11043 arg2Of considered,were
R5956 T11045 T11044 arg3Of significant,considered
R6007 T11243 T11242 arg1Of production,IL-17
R6008 T11243 T11244 arg1Of production,in
R6009 T11243 T11246 arg1Of production,from
R6010 T11245 T11244 arg2Of PBMC,in
R6011 T11247 T11246 arg2Of patients,from
R6012 T11247 T11248 arg1Of patients,with
R6013 T11249 T11250 arg1Of RA,","
R6014 T11250 T11254 arg1Of ",",and
R6015 T11251 T11250 arg2Of patients,","
R6016 T11251 T11252 arg1Of patients,with
R6017 T11253 T11252 arg2Of OA,with
R6018 T11254 T11248 arg2Of and,with
R6019 T11256 T11254 arg2Of individuals,and
R6020 T11256 T11255 arg1Of individuals,normal
R6021 T11257 T11258 arg1Of PBMC,were
R6022 T11257 T11259 arg2Of PBMC,separated
R6023 T11257 T11261 arg2Of PBMC,cultured
R6024 T11259 T11260 arg1Of separated,and
R6025 T11260 T11258 arg2Of and,were
R6026 T11260 T11262 arg1Of and,with
R6027 T11260 T11281 arg1Of and,;
R6028 T11261 T11260 arg2Of cultured,and
R6029 T11263 T11262 arg2Of PHA,with
R6030 T11263 T11264 arg1Of PHA,(
R6031 T11263 T11268 arg1Of PHA,from
R6032 T11266 T11264 arg2Of μg/ml,(
R6033 T11266 T11265 arg1Of μg/ml,5
R6034 T11267 T11264 arg3Of ),(
R6035 T11269 T11270 arg1Of patients,with
R6036 T11269 T11272 arg1Of patients,","
R6037 T11271 T11270 arg2Of RA,with
R6038 T11272 T11277 arg1Of ",",and
R6039 T11273 T11272 arg2Of patients,","
R6040 T11273 T11274 arg1Of patients,with
R6041 T11275 T11274 arg2Of OA,with
R6042 T11277 T11268 arg2Of and,from
R6043 T11277 T11276 arg1Of and,","
R6044 T11280 T11277 arg2Of controls,and
R6045 T11280 T11278 arg1Of controls,age-matched
R6046 T11280 T11279 arg1Of controls,normal
R6047 T11283 T11282 arg1Of levels,IL-17
R6048 T11283 T11284 arg1Of levels,were
R6049 T11283 T11286 arg2Of levels,determined
R6050 T11286 T11281 arg2Of determined,;
R6051 T11286 T11284 arg2Of determined,were
R6052 T11286 T11285 arg1Of determined,then
R6053 T11286 T11287 arg1Of determined,in
R6054 T11290 T11287 arg2Of supernatants,in
R6055 T11290 T11288 arg1Of supernatants,the
R6056 T11290 T11289 arg1Of supernatants,culture
R6057 T11290 T11291 arg1Of supernatants,(
R6058 T11292 T11291 arg2Of Fig.,(
R6059 T11292 T11293 arg1Of Fig.,1
R6060 T11294 T11291 arg3Of ),(
R6061 T11297 T11296 arg1Of amounts,the
R6062 T11297 T11298 arg1Of amounts,of
R6063 T11297 T11302 arg1Of amounts,were
R6064 T11297 T11304 arg1Of amounts,different
R6065 T11301 T11298 arg2Of secretion,of
R6066 T11301 T11299 arg1Of secretion,basal
R6067 T11301 T11300 arg1Of secretion,IL-17
R6068 T11302 T11295 arg2Of were,Although
R6069 T11302 T11303 arg1Of were,not
R6070 T11304 T11302 arg2Of different,were
R6071 T11304 T11305 arg1Of different,between
R6072 T11306 T11307 arg1Of RA,","
R6073 T11307 T11309 arg1Of ",",and
R6074 T11308 T11307 arg2Of OA,","
R6075 T11309 T11305 arg2Of and,between
R6076 T11309 T11312 arg1Of and,(
R6077 T11311 T11309 arg2Of controls,and
R6078 T11311 T11310 arg1Of controls,normal
R6079 T11314 T11313 arg1Of ±,62
R6080 T11315 T11316 arg1Of 31,","
R6081 T11317 T11316 arg2Of 43,","
R6082 T11319 T11320 arg1Of 19,and
R6083 T11321 T11320 arg2Of 43,and
R6084 T11323 T11322 arg1Of 10,±
R6085 T11324 T11312 arg2Of pg/ml,(
R6086 T11324 T11314 arg1Of pg/ml,±
R6087 T11324 T11315 arg1Of pg/ml,31
R6088 T11324 T11317 arg1Of pg/ml,43
R6089 T11324 T11318 arg1Of pg/ml,±
R6090 T11324 T11319 arg1Of pg/ml,19
R6091 T11324 T11321 arg1Of pg/ml,43
R6092 T11324 T11323 arg1Of pg/ml,10
R6093 T11324 T11325 arg1Of pg/ml,","
R6094 T11324 T11326 arg1Of pg/ml,respectively
R6095 T11327 T11312 arg3Of ),(
R6096 T11331 T11329 arg1Of production,the
R6097 T11331 T11330 arg1Of production,IL-17
R6098 T11331 T11332 arg2Of production,stimulated
R6099 T11331 T11335 arg1Of production,was
R6100 T11331 T11337 arg1Of production,higher
R6101 T11334 T11332 arg1Of PHA,stimulated
R6102 T11334 T11333 arg2Of PHA,by
R6103 T11335 T11295 arg1Of was,Although
R6104 T11335 T11328 arg1Of was,","
R6105 T11337 T11335 arg2Of higher,was
R6106 T11337 T11336 arg1Of higher,significantly
R6107 T11337 T11338 arg1Of higher,in
R6108 T11337 T11341 arg1Of higher,than
R6109 T11340 T11338 arg2Of PBMC,in
R6110 T11340 T11339 arg1Of PBMC,RA
R6111 T11342 T11341 arg2Of in,than
R6112 T11343 T11342 arg2Of those,in
R6113 T11343 T11344 arg1Of those,from
R6114 T11345 T11346 arg1Of OA,and
R6115 T11346 T11344 arg2Of and,from
R6116 T11347 T11346 arg2Of controls,and
R6117 T11347 T11348 arg1Of controls,(
R6118 T11355 T11352 arg1Of 211,versus
R6119 T11355 T11353 arg1Of 211,463
R6120 T11355 T11354 arg1Of 211,±
R6121 T11356 T11349 arg1Of pg/ml,768
R6122 T11356 T11350 arg1Of pg/ml,±
R6123 T11356 T11351 arg1Of pg/ml,295
R6124 T11356 T11355 arg1Of pg/ml,211
R6125 T11356 T11357 arg1Of pg/ml,[
R6126 T11356 T11362 arg1Of pg/ml,and
R6127 T11358 T11357 arg2Of P,[
R6128 T11358 T11359 arg1Of P,<
R6129 T11358 T11360 arg1Of P,0.05
R6130 T11361 T11357 arg3Of ],[
R6131 T11362 T11348 arg2Of and,(
R6132 T11365 T11364 arg1Of 29,±
R6133 T11366 T11362 arg2Of pg/ml,and
R6134 T11366 T11363 arg1Of pg/ml,241
R6135 T11366 T11365 arg1Of pg/ml,29
R6136 T11366 T11367 arg1Of pg/ml,[
R6137 T11368 T11367 arg2Of P,[
R6138 T11368 T11369 arg1Of P,<
R6139 T11368 T11370 arg1Of P,0.001
R6140 T11371 T11367 arg3Of ],[
R6141 T11372 T11348 arg3Of ),(
R6340 T11797 T11795 arg2Of production,Increased
R6341 T11797 T11796 arg1Of production,IL-17
R6342 T11797 T11798 arg1Of production,in
R6343 T11797 T11804 arg1Of production,by
R6344 T11799 T11798 arg2Of PBMC,in
R6345 T11799 T11800 arg1Of PBMC,of
R6346 T11801 T11800 arg2Of patients,of
R6347 T11801 T11802 arg1Of patients,with
R6348 T11803 T11802 arg2Of RA,with
R6349 T11805 T11806 arg1Of anti-CD3,and/or
R6350 T11806 T11809 arg1Of and/or,and
R6351 T11807 T11806 arg2Of anti-CD28,and/or
R6352 T11809 T11804 arg2Of and,by
R6353 T11809 T11808 arg1Of and,","
R6354 T11810 T11809 arg2Of PHA,and
R6355 T11812 T11813 arg1Of IL-17,was
R6356 T11812 T11815 arg2Of IL-17,known
R6357 T11815 T11811 arg2Of known,Because
R6358 T11815 T11813 arg2Of known,was
R6359 T11815 T11814 arg1Of known,already
R6360 T11815 T11816 arg1Of known,from
R6361 T11818 T11816 arg2Of reports,from
R6362 T11818 T11817 arg1Of reports,earlier
R6363 T11818 T11819 modOf reports,to
R6364 T11818 T11820 arg1Of reports,be
R6365 T11818 T11821 arg2Of reports,produced
R6366 T11821 T11819 arg1Of produced,to
R6367 T11821 T11820 arg2Of produced,be
R6368 T11821 T11822 arg1Of produced,mainly
R6369 T11826 T11821 arg1Of cells,produced
R6370 T11826 T11823 arg2Of cells,by
R6371 T11826 T11824 arg2Of cells,activated
R6372 T11826 T11825 arg1Of cells,T
R6373 T11828 T11829 arg1Of we,investigated
R6374 T11829 T11811 arg1Of investigated,Because
R6375 T11829 T11827 arg1Of investigated,","
R6376 T11829 T11845 arg1Of investigated,as
R6377 T11831 T11829 arg2Of effect,investigated
R6378 T11831 T11830 arg1Of effect,the
R6379 T11831 T11832 arg1Of effect,of
R6380 T11834 T11832 arg2Of concentrations,of
R6381 T11834 T11833 arg1Of concentrations,different
R6382 T11834 T11835 arg1Of concentrations,of
R6383 T11834 T11837 arg1Of concentrations,(
R6384 T11836 T11835 arg2Of anti-CD3,of
R6385 T11838 T11839 arg1Of 1,","
R6386 T11839 T11841 arg1Of ",",and
R6387 T11840 T11839 arg2Of 5,","
R6388 T11842 T11841 arg2Of 10,and
R6389 T11843 T11837 arg2Of μg/ml,(
R6390 T11843 T11838 arg1Of μg/ml,1
R6391 T11843 T11840 arg1Of μg/ml,5
R6392 T11843 T11842 arg1Of μg/ml,10
R6393 T11844 T11837 arg3Of ),(
R6394 T11849 T11845 arg2Of activation,as
R6395 T11849 T11846 arg1Of activation,a
R6396 T11849 T11847 arg1Of activation,T
R6397 T11849 T11848 arg1Of activation,cell
R6398 T11849 T11850 arg1Of activation,","
R6399 T11849 T11851 arg1Of activation,which
R6400 T11849 T11852 arg1Of activation,showed
R6401 T11855 T11852 arg2Of increase,showed
R6402 T11855 T11853 arg1Of increase,a
R6403 T11855 T11854 arg1Of increase,dose-dependent
R6404 T11855 T11856 arg1Of increase,in
R6405 T11858 T11856 arg2Of levels,in
R6406 T11858 T11857 arg1Of levels,IL-17
R6407 T11858 T11859 arg1Of levels,(
R6408 T11860 T11859 arg2Of data,(
R6409 T11860 T11862 arg2Of data,shown
R6410 T11862 T11861 arg1Of shown,not
R6411 T11863 T11859 arg3Of ),(
R6412 T11866 T11864 arg2Of basis,On
R6413 T11866 T11865 arg1Of basis,the
R6414 T11866 T11867 arg1Of basis,of
R6415 T11868 T11867 arg2Of this,of
R6416 T11870 T11871 arg1Of we,chose
R6417 T11871 T11864 arg1Of chose,On
R6418 T11871 T11869 arg1Of chose,","
R6419 T11871 T11874 arg1Of chose,as
R6420 T11873 T11871 arg2Of μg/ml,chose
R6421 T11873 T11872 arg1Of μg/ml,10
R6422 T11877 T11874 arg2Of concentration,as
R6423 T11877 T11875 arg1Of concentration,a
R6424 T11877 T11876 arg1Of concentration,stimulation
R6425 T11877 T11878 arg1Of concentration,for
R6426 T11879 T11878 arg2Of anti-CD3,for
R6427 T11881 T11880 arg2Of shown,As
R6428 T11881 T11882 arg1Of shown,in
R6429 T11884 T11882 arg2Of 1,in
R6430 T11884 T11883 arg1Of 1,Table
R6431 T11886 T11888 arg1Of anti-CD3,upregulated
R6432 T11888 T11880 arg1Of upregulated,As
R6433 T11888 T11885 arg1Of upregulated,","
R6434 T11888 T11887 arg1Of upregulated,significantly
R6435 T11888 T11895 arg1Of upregulated,and
R6436 T11890 T11888 arg2Of production,upregulated
R6437 T11890 T11889 arg1Of production,IL-17
R6438 T11890 T11892 arg1Of production,to
R6439 T11892 T11891 arg1Of to,up
R6440 T11893 T11892 arg2Of 3.7-fold,to
R6441 T11895 T11894 arg1Of and,","
R6442 T11897 T11896 arg1Of combination,the
R6443 T11897 T11898 arg1Of combination,of
R6444 T11897 T11902 arg1Of combination,produced
R6445 T11899 T11900 arg1Of anti-CD28,and
R6446 T11900 T11898 arg2Of and,of
R6447 T11901 T11900 arg2Of anti-CD3,and
R6448 T11902 T11895 arg2Of produced,and
R6449 T11902 T11905 arg1Of produced,(
R6450 T11902 T11909 arg1Of produced,than
R6451 T11904 T11902 arg2Of IL-17,produced
R6452 T11904 T11903 arg1Of IL-17,more
R6453 T11907 T11905 arg2Of 1.3-1.5-fold,(
R6454 T11907 T11906 arg1Of 1.3-1.5-fold,approximately
R6455 T11908 T11905 arg3Of ),(
R6456 T11910 T11909 arg2Of anti-CD3,than
R6457 T11910 T11911 arg1Of anti-CD3,alone
R6458 T11915 T11914 arg2Of incubated,when
R6459 T11915 T11916 arg1Of incubated,with
R6460 T11919 T11916 arg2Of mitogens,with
R6461 T11919 T11917 arg1Of mitogens,T
R6462 T11919 T11918 arg1Of mitogens,cell
R6463 T11919 T11921 arg1Of mitogens,as
R6464 T11921 T11920 arg1Of as,such
R6465 T11922 T11921 arg2Of PHA,as
R6466 T11926 T11915 arg1Of production,incubated
R6467 T11926 T11924 arg2Of production,increased
R6468 T11926 T11925 arg1Of production,IL-17
R6469 T11926 T11927 arg1Of production,was
R6470 T11926 T11929 arg1Of production,pronounced
R6471 T11927 T11912 arg1Of was,Furthermore
R6472 T11927 T11913 arg1Of was,","
R6473 T11927 T11914 arg1Of was,when
R6474 T11927 T11923 arg1Of was,","
R6475 T11929 T11927 arg2Of pronounced,was
R6476 T11929 T11928 arg1Of pronounced,more
R6477 T11929 T11930 arg1Of pronounced,than
R6478 T11929 T11935 arg1Of pronounced,(
R6479 T11931 T11930 arg2Of with,than
R6480 T11932 T11933 arg1Of anti-CD3,and
R6481 T11933 T11931 arg2Of and,with
R6482 T11934 T11933 arg2Of anti-CD28,and
R6483 T11942 T11939 arg1Of 1,versus
R6484 T11942 T11940 arg1Of 1,211
R6485 T11942 T11941 arg1Of 1,±
R6486 T11943 T11935 arg2Of pg/ml,(
R6487 T11943 T11936 arg1Of pg/ml,588
R6488 T11943 T11937 arg1Of pg/ml,±
R6489 T11943 T11938 arg1Of pg/ml,85
R6490 T11943 T11942 arg1Of pg/ml,1
R6491 T11943 T11944 arg1Of pg/ml,;
R6492 T11945 T11944 arg2Of P,;
R6493 T11945 T11946 arg1Of P,<
R6494 T11945 T11947 arg1Of P,0.05
R6495 T11948 T11935 arg3Of ),(
R6787 T12640 T12641 arg1Of Regulation,of
R6788 T12640 T12647 arg1Of Regulation,by
R6789 T12643 T12641 arg2Of production,of
R6790 T12643 T12642 arg1Of production,IL-17
R6791 T12643 T12644 arg1Of production,in
R6792 T12646 T12644 arg2Of PBMC,in
R6793 T12646 T12645 arg1Of PBMC,RA
R6794 T12649 T12648 arg1Of cytokines,inflammatory
R6795 T12649 T12650 arg1Of cytokines,and
R6796 T12650 T12647 arg2Of and,by
R6797 T12651 T12650 arg2Of chemokines,and
R6798 T12654 T12653 arg1Of PBMC,RA
R6799 T12654 T12655 arg1Of PBMC,include
R6800 T12655 T12652 arg2Of include,Because
R6801 T12655 T12659 arg1Of include,in
R6802 T12658 T12655 arg2Of types,include
R6803 T12658 T12656 arg1Of types,several
R6804 T12658 T12657 arg1Of types,cell
R6805 T12660 T12659 arg2Of addition,in
R6806 T12660 T12661 arg1Of addition,to
R6807 T12663 T12661 arg2Of cells,to
R6808 T12663 T12662 arg1Of cells,T
R6809 T12667 T12665 arg1Of cytokines,some
R6810 T12667 T12666 arg1Of cytokines,inflammatory
R6811 T12667 T12668 arg2Of cytokines,released
R6812 T12667 T12674 arg1Of cytokines,might
R6813 T12667 T12675 arg1Of cytokines,have
R6814 T12667 T12676 arg1Of cytokines,affected
R6815 T12668 T12669 arg1Of released,from
R6816 T12670 T12671 arg1Of macrophages,and
R6817 T12671 T12669 arg2Of and,from
R6818 T12673 T12671 arg2Of lymphocytes,and
R6819 T12673 T12672 arg1Of lymphocytes,other
R6820 T12676 T12652 arg1Of affected,Because
R6821 T12676 T12664 arg1Of affected,","
R6822 T12676 T12674 arg2Of affected,might
R6823 T12676 T12675 arg2Of affected,have
R6824 T12678 T12676 arg2Of production,affected
R6825 T12678 T12677 arg1Of production,the
R6826 T12678 T12679 arg1Of production,of
R6827 T12680 T12679 arg2Of IL-17,of
R6828 T12680 T12681 arg1Of IL-17,from
R6829 T12683 T12681 arg2Of cells,from
R6830 T12683 T12682 arg1Of cells,T
R6831 T12685 T12684 arg1Of evaluate,To
R6832 T12687 T12685 arg2Of effects,evaluate
R6833 T12687 T12686 arg1Of effects,the
R6834 T12687 T12688 arg1Of effects,of
R6835 T12690 T12688 arg2Of cytokines,of
R6836 T12690 T12689 arg1Of cytokines,inflammatory
R6837 T12690 T12691 arg2Of cytokines,released
R6838 T12694 T12691 arg1Of PBMC,released
R6839 T12694 T12692 arg2Of PBMC,by
R6840 T12694 T12693 arg2Of PBMC,activated
R6841 T12696 T12685 arg1Of we,evaluate
R6842 T12696 T12697 arg1Of we,tested
R6843 T12697 T12684 modOf tested,To
R6844 T12697 T12695 arg1Of tested,","
R6845 T12699 T12697 arg2Of effects,tested
R6846 T12699 T12698 arg1Of effects,the
R6847 T12699 T12700 arg1Of effects,of
R6848 T12702 T12701 arg1Of cytokines,several
R6849 T12702 T12703 arg1Of cytokines,and
R6850 T12703 T12700 arg2Of and,of
R6851 T12703 T12705 arg1Of and,on
R6852 T12704 T12703 arg2Of chemokines,and
R6853 T12707 T12705 arg2Of production,on
R6854 T12707 T12706 arg1Of production,IL-17
R6855 T12708 T12709 arg1Of We,detected
R6856 T12709 T12715 arg1Of detected,after
R6857 T12709 T12723 arg1Of detected,","
R6858 T12709 T12724 arg1Of detected,whereas
R6859 T12711 T12709 arg2Of increase,detected
R6860 T12711 T12710 arg1Of increase,an
R6861 T12711 T12712 arg1Of increase,in
R6862 T12714 T12712 arg2Of level,in
R6863 T12714 T12713 arg1Of level,IL-17
R6864 T12716 T12715 arg2Of stimulation,after
R6865 T12716 T12717 arg1Of stimulation,with
R6866 T12718 T12717 arg2Of IL-15,with
R6867 T12718 T12719 arg1Of IL-15,(
R6868 T12721 T12719 arg2Of ng/ml,(
R6869 T12721 T12720 arg1Of ng/ml,10
R6870 T12722 T12719 arg3Of ),(
R6871 T12726 T12727 arg1Of IL-1β,(
R6872 T12726 T12731 arg1Of IL-1β,","
R6873 T12729 T12727 arg2Of ng/ml,(
R6874 T12729 T12728 arg1Of ng/ml,10
R6875 T12730 T12727 arg3Of ),(
R6876 T12731 T12737 arg1Of ",",","
R6877 T12732 T12731 arg2Of TNF-α,","
R6878 T12732 T12733 arg1Of TNF-α,(
R6879 T12735 T12733 arg2Of ng/ml,(
R6880 T12735 T12734 arg1Of ng/ml,10
R6881 T12736 T12733 arg3Of ),(
R6882 T12737 T12743 arg1Of ",",or
R6883 T12738 T12737 arg2Of IL-18,","
R6884 T12738 T12739 arg1Of IL-18,(
R6885 T12741 T12739 arg2Of ng/ml,(
R6886 T12741 T12740 arg1Of ng/ml,10
R6887 T12742 T12739 arg3Of ),(
R6888 T12743 T12725 arg2Of or,with
R6889 T12744 T12743 arg2Of TGF-β,or
R6890 T12744 T12745 arg1Of TGF-β,(
R6891 T12747 T12745 arg2Of ng/ml,(
R6892 T12747 T12746 arg1Of ng/ml,10
R6893 T12748 T12745 arg3Of ),(
R6894 T12750 T12749 arg1Of levels,the
R6895 T12750 T12751 arg1Of levels,in
R6896 T12750 T12753 arg1Of levels,were
R6897 T12750 T12754 arg1Of levels,unchanged
R6898 T12752 T12751 arg2Of IL-17,in
R6899 T12753 T12724 arg2Of were,whereas
R6900 T12753 T12725 arg1Of were,with
R6901 T12754 T12753 arg2Of unchanged,were
R6902 T12754 T12755 arg1Of unchanged,(
R6903 T12757 T12755 arg2Of 2a,(
R6904 T12757 T12756 arg1Of 2a,Fig.
R6905 T12758 T12755 arg3Of ),(
R6906 T12760 T12759 arg2Of treated,When
R6907 T12760 T12761 arg1Of treated,with
R6908 T12762 T12763 arg1Of MCP-1,(
R6909 T12762 T12767 arg1Of MCP-1,or
R6910 T12765 T12763 arg2Of ng/ml,(
R6911 T12765 T12764 arg1Of ng/ml,10
R6912 T12766 T12763 arg3Of ),(
R6913 T12767 T12761 arg2Of or,with
R6914 T12768 T12767 arg2Of IL-6,or
R6915 T12768 T12769 arg1Of IL-6,(
R6916 T12771 T12769 arg2Of ng/ml,(
R6917 T12771 T12770 arg1Of ng/ml,10
R6918 T12772 T12769 arg3Of ),(
R6919 T12775 T12774 arg1Of upregulations,significant
R6920 T12775 T12776 arg1Of upregulations,of
R6921 T12775 T12779 arg1Of upregulations,were
R6922 T12775 T12780 arg2Of upregulations,observed
R6923 T12778 T12776 arg2Of proteins,of
R6924 T12778 T12777 arg1Of proteins,IL-17
R6925 T12780 T12759 arg1Of observed,When
R6926 T12780 T12773 arg1Of observed,","
R6927 T12780 T12779 arg2Of observed,were
R6928 T12780 T12781 arg1Of observed,(
R6929 T12780 T12801 arg1Of observed,","
R6930 T12780 T12802 arg1Of observed,whereas
R6931 T12782 T12783 arg1Of 62,±
R6932 T12783 T12785 arg1Of ±,and
R6933 T12784 T12783 arg2Of 42,±
R6934 T12785 T12787 arg1Of and,±
R6935 T12786 T12785 arg2Of 50,and
R6936 T12788 T12782 arg1Of 10,62
R6937 T12788 T12784 arg1Of 10,42
R6938 T12788 T12786 arg1Of 10,50
R6939 T12792 T12789 arg1Of 11,versus
R6940 T12792 T12790 arg1Of 11,31
R6941 T12792 T12791 arg1Of 11,±
R6942 T12793 T12781 arg2Of pg/ml,(
R6943 T12793 T12788 arg1Of pg/ml,10
R6944 T12793 T12792 arg1Of pg/ml,11
R6945 T12793 T12794 arg1Of pg/ml,","
R6946 T12793 T12795 arg1Of pg/ml,respectively
R6947 T12793 T12796 arg1Of pg/ml,;
R6948 T12797 T12796 arg2Of P,;
R6949 T12797 T12798 arg1Of P,<
R6950 T12797 T12799 arg1Of P,0.05
R6951 T12800 T12781 arg3Of ),(
R6952 T12803 T12804 arg1Of none,was
R6953 T12803 T12805 arg2Of none,observed
R6954 T12805 T12802 arg2Of observed,whereas
R6955 T12805 T12804 arg2Of observed,was
R6956 T12805 T12806 arg1Of observed,with
R6957 T12807 T12808 arg1Of IL-8,(
R6958 T12807 T12812 arg1Of IL-8,","
R6959 T12810 T12808 arg2Of ng/ml,(
R6960 T12810 T12809 arg1Of ng/ml,10
R6961 T12811 T12808 arg3Of ),(
R6962 T12812 T12818 arg1Of ",",or
R6963 T12813 T12812 arg2Of MIP-1α,","
R6964 T12813 T12814 arg1Of MIP-1α,(
R6965 T12816 T12814 arg2Of ng/ml,(
R6966 T12816 T12815 arg1Of ng/ml,10
R6967 T12817 T12814 arg3Of ),(
R6968 T12818 T12806 arg2Of or,with
R6969 T12819 T12818 arg2Of MIP-1β,or
R6970 T12819 T12820 arg1Of MIP-1β,(
R6971 T12819 T12824 arg1Of MIP-1β,(
R6972 T12822 T12820 arg2Of ng/ml,(
R6973 T12822 T12821 arg1Of ng/ml,10
R6974 T12823 T12820 arg3Of ),(
R6975 T12826 T12824 arg2Of 2b,(
R6976 T12826 T12825 arg1Of 2b,Fig.
R6977 T12827 T12824 arg3Of ),(
R7308 T13598 T13599 arg1Of Inhibition,of
R7309 T13598 T13602 arg1Of Inhibition,by
R7310 T13601 T13599 arg2Of production,of
R7311 T13601 T13600 arg1Of production,IL-17
R7312 T13605 T13603 arg1Of inhibitors,signal
R7313 T13605 T13604 arg1Of inhibitors,transduction
R7314 T13605 T13606 arg1Of inhibitors,and
R7315 T13606 T13602 arg2Of and,by
R7316 T13608 T13606 arg2Of drugs,and
R7317 T13608 T13607 arg1Of drugs,anti-rheumatic
R7318 T13610 T13609 arg2Of observed,Having
R7319 T13614 T13610 arg2Of production,observed
R7320 T13614 T13611 arg1Of production,the
R7321 T13614 T13612 arg2Of production,increased
R7322 T13614 T13613 arg1Of production,IL-17
R7323 T13614 T13615 arg1Of production,in
R7324 T13617 T13615 arg2Of PBMC,in
R7325 T13617 T13616 arg1Of PBMC,RA
R7326 T13620 T13609 modOf was,Having
R7327 T13620 T13618 arg1Of was,","
R7328 T13621 T13620 arg2Of important,was
R7329 T13623 T13609 arg1Of know,Having
R7330 T13623 T13610 arg1Of know,observed
R7331 T13623 T13619 arg1Of know,it
R7332 T13623 T13620 arg1Of know,was
R7333 T13623 T13621 arg1Of know,important
R7334 T13623 T13622 arg1Of know,to
R7335 T13624 T13623 arg2Of which,know
R7336 T13627 T13624 arg1Of pathways,which
R7337 T13627 T13625 arg1Of pathways,signal
R7338 T13627 T13626 arg1Of pathways,transduction
R7339 T13627 T13628 arg1Of pathways,were
R7340 T13627 T13629 arg2Of pathways,involved
R7341 T13629 T13628 arg2Of involved,were
R7342 T13631 T13630 arg2Of illustrated,As
R7343 T13631 T13632 arg1Of illustrated,in
R7344 T13633 T13632 arg2Of Fig.,in
R7345 T13633 T13634 arg1Of Fig.,3
R7346 T13638 T13636 arg1Of decrease,an
R7347 T13638 T13637 arg1Of decrease,significant
R7348 T13638 T13639 arg1Of decrease,in
R7349 T13638 T13643 arg1Of decrease,was
R7350 T13638 T13644 arg2Of decrease,observed
R7351 T13642 T13639 arg2Of production,in
R7352 T13642 T13640 arg1Of production,anti-CD3-induced
R7353 T13642 T13641 arg1Of production,IL-17
R7354 T13644 T13630 arg1Of observed,As
R7355 T13644 T13635 arg1Of observed,","
R7356 T13644 T13643 arg2Of observed,was
R7357 T13644 T13645 arg1Of observed,when
R7358 T13644 T13659 arg1Of observed,(
R7359 T13646 T13645 arg2Of co-incubated,when
R7360 T13646 T13647 arg1Of co-incubated,with
R7361 T13646 T13654 arg1Of co-incubated,in
R7362 T13649 T13648 arg1Of inhibitor,NF-κB
R7363 T13649 T13650 arg1Of inhibitor,","
R7364 T13650 T13652 arg1Of ",",and
R7365 T13651 T13650 arg2Of PDTC,","
R7366 T13652 T13647 arg2Of and,with
R7367 T13653 T13652 arg2Of dexamethasone,and
R7368 T13654 T13656 arg1Of in,with
R7369 T13655 T13654 arg2Of comparison,in
R7370 T13657 T13654 arg3Of anti-CD3,in
R7371 T13657 T13658 arg1Of anti-CD3,alone
R7372 T13660 T13661 arg1Of 38,±
R7373 T13661 T13663 arg1Of ±,and
R7374 T13662 T13661 arg2Of 5,±
R7375 T13664 T13665 arg1Of 54,±
R7376 T13665 T13663 arg2Of ±,and
R7377 T13666 T13665 arg2Of 11,±
R7378 T13670 T13660 arg1Of 19,38
R7379 T13670 T13662 arg1Of 19,5
R7380 T13670 T13664 arg1Of 19,54
R7381 T13670 T13666 arg1Of 19,11
R7382 T13670 T13667 arg1Of 19,versus
R7383 T13670 T13668 arg1Of 19,98
R7384 T13670 T13669 arg1Of 19,±
R7385 T13671 T13659 arg2Of pg/ml,(
R7386 T13671 T13670 arg1Of pg/ml,19
R7387 T13671 T13672 arg1Of pg/ml,","
R7388 T13671 T13673 arg1Of pg/ml,respectively
R7389 T13671 T13674 arg1Of pg/ml,;
R7390 T13675 T13674 arg2Of P,;
R7391 T13675 T13676 arg1Of P,<
R7392 T13675 T13677 arg1Of P,0.05
R7393 T13678 T13659 arg3Of ),(
R7394 T13679 T13680 arg1Of LY294002,and
R7395 T13680 T13691 arg1Of and,inhibited
R7396 T13681 T13680 arg2Of wortmannin,and
R7397 T13685 T13683 arg2Of inhibitor,as
R7398 T13685 T13684 arg1Of inhibitor,an
R7399 T13685 T13686 arg1Of inhibitor,of
R7400 T13687 T13686 arg2Of PI3K,of
R7401 T13691 T13682 arg1Of inhibited,","
R7402 T13691 T13683 arg1Of inhibited,as
R7403 T13691 T13688 arg1Of inhibited,","
R7404 T13691 T13689 arg1Of inhibited,also
R7405 T13691 T13690 arg1Of inhibited,markedly
R7406 T13695 T13691 arg2Of production,inhibited
R7407 T13695 T13692 arg1Of production,the
R7408 T13695 T13693 arg1Of production,anti-CD3-induced
R7409 T13695 T13694 arg1Of production,IL-17
R7410 T13695 T13696 arg1Of production,in
R7411 T13695 T13699 arg1Of production,(
R7412 T13698 T13696 arg2Of PBMC,in
R7413 T13698 T13697 arg1Of PBMC,RA
R7414 T13706 T13700 arg1Of 10,98
R7415 T13706 T13701 arg1Of 10,±
R7416 T13706 T13702 arg1Of 10,19
R7417 T13706 T13703 arg1Of 10,versus
R7418 T13706 T13704 arg1Of 10,38
R7419 T13706 T13705 arg1Of 10,±
R7420 T13707 T13708 arg1Of pg/ml,[
R7421 T13707 T13713 arg1Of pg/ml,and
R7422 T13709 T13708 arg2Of P,[
R7423 T13709 T13710 arg1Of P,<
R7424 T13709 T13711 arg1Of P,0.005
R7425 T13712 T13708 arg3Of ],[
R7426 T13713 T13699 arg2Of and,(
R7427 T13713 T13706 arg1Of and,10
R7428 T13713 T13723 arg1Of and,","
R7429 T13713 T13724 arg1Of and,respectively
R7430 T13714 T13715 arg1Of 48,±
R7431 T13716 T13715 arg2Of 4,±
R7432 T13717 T13713 arg2Of pg/ml,and
R7433 T13717 T13714 arg1Of pg/ml,48
R7434 T13717 T13716 arg1Of pg/ml,4
R7435 T13717 T13718 arg1Of pg/ml,[
R7436 T13719 T13718 arg2Of P,[
R7437 T13719 T13720 arg1Of P,<
R7438 T13719 T13721 arg1Of P,0.05
R7439 T13722 T13718 arg3Of ],[
R7440 T13725 T13699 arg3Of ),(
R7441 T13728 T13726 arg1Of inhibitors,The
R7442 T13728 T13727 arg1Of inhibitors,calcineurin
R7443 T13730 T13729 arg1Of A,cyclosporin
R7444 T13730 T13731 arg1Of A,and
R7445 T13731 T13728 arg1Of and,inhibitors
R7446 T13731 T13734 arg1Of and,downregulated
R7447 T13732 T13731 arg2Of FK506,and
R7448 T13734 T13733 arg1Of downregulated,also
R7449 T13734 T13739 arg1Of downregulated,well
R7450 T13734 T13752 arg1Of downregulated,","
R7451 T13734 T13753 arg1Of downregulated,whereas
R7452 T13737 T13734 arg2Of secretion,downregulated
R7453 T13737 T13735 arg1Of secretion,the
R7454 T13737 T13736 arg1Of secretion,IL-17
R7455 T13739 T13738 arg1Of well,as
R7456 T13740 T13739 arg2Of as,well
R7457 T13744 T13742 arg1Of kinase,mitogen-activated
R7458 T13744 T13743 arg1Of kinase,protein
R7459 T13744 T13745 arg1Of kinase,(
R7460 T13746 T13745 arg2Of MAPK,(
R7461 T13747 T13745 arg3Of ),(
R7462 T13750 T13741 arg1Of SB203580,the
R7463 T13750 T13744 arg1Of SB203580,kinase
R7464 T13750 T13748 arg1Of SB203580,p38
R7465 T13750 T13749 arg1Of SB203580,inhibitor
R7466 T13750 T13751 arg1Of SB203580,did
R7467 T13751 T13740 arg2Of did,as
R7468 T13754 T13755 arg1Of rapamycin,and
R7469 T13755 T13757 arg1Of and,had
R7470 T13756 T13755 arg2Of PD98059,and
R7471 T13757 T13753 arg2Of had,whereas
R7472 T13757 T13760 arg1Of had,on
R7473 T13759 T13757 arg2Of effect,had
R7474 T13759 T13758 arg1Of effect,no
R7475 T13762 T13760 arg2Of levels,on
R7476 T13762 T13761 arg1Of levels,IL-17
R7477 T13762 T13763 arg1Of levels,(
R7478 T13764 T13763 arg2Of Fig.,(
R7479 T13764 T13765 arg1Of Fig.,3
R7480 T13766 T13763 arg3Of ),(
R7481 T13768 T13767 arg1Of evaluate,To
R7482 T13768 T13777 arg1Of evaluate,at
R7483 T13770 T13768 arg2Of possibility,evaluate
R7484 T13770 T13769 arg1Of possibility,the
R7485 T13770 T13771 arg1Of possibility,of
R7486 T13770 T13774 arg1Of possibility,by
R7487 T13773 T13771 arg2Of inhibition,of
R7488 T13773 T13772 arg1Of inhibition,non-specific
R7489 T13776 T13774 arg2Of drug,by
R7490 T13776 T13775 arg1Of drug,the
R7491 T13779 T13777 arg2Of concentrations,at
R7492 T13779 T13778 arg1Of concentrations,high
R7493 T13781 T13768 arg1Of we,evaluate
R7494 T13781 T13782 arg1Of we,observed
R7495 T13782 T13767 modOf observed,To
R7496 T13782 T13780 arg1Of observed,","
R7497 T13785 T13782 arg2Of response,observed
R7498 T13785 T13783 arg1Of response,the
R7499 T13785 T13784 arg1Of response,dose
R7500 T13785 T13786 arg1Of response,of
R7501 T13785 T13790 arg1Of response,for
R7502 T13787 T13788 arg1Of PDTC,and
R7503 T13788 T13786 arg2Of and,of
R7504 T13789 T13788 arg2Of LY294002,and
R7505 T13792 T13790 arg2Of inhibition,for
R7506 T13792 T13791 arg1Of inhibition,the
R7507 T13792 T13793 arg1Of inhibition,of
R7508 T13795 T13793 arg2Of production,of
R7509 T13795 T13794 arg1Of production,IL-17
R7510 T13795 T13796 arg1Of production,in
R7511 T13797 T13796 arg2Of PBMC,in
R7512 T13798 T13799 arg1Of There,were
R7513 T13801 T13799 arg2Of inhibitions,were
R7514 T13801 T13800 arg1Of inhibitions,dose-dependent
R7515 T13801 T13802 arg1Of inhibitions,of
R7516 T13804 T13802 arg2Of production,of
R7517 T13804 T13803 arg1Of production,IL-17
R7518 T13804 T13805 arg1Of production,with
R7519 T13807 T13805 arg2Of inhibitors,with
R7520 T13807 T13806 arg1Of inhibitors,chemical
R7521 T13807 T13808 arg1Of inhibitors,(
R7522 T13810 T13808 arg2Of 4a,(
R7523 T13810 T13809 arg1Of 4a,Fig.
R7524 T13811 T13808 arg3Of ),(
R7525 T13814 T13812 arg1Of inhibitors,The
R7526 T13814 T13813 arg1Of inhibitors,other
R7527 T13814 T13815 arg1Of inhibitors,in
R7528 T13814 T13821 arg1Of inhibitors,showed
R7529 T13816 T13815 arg2Of addition,in
R7530 T13816 T13817 arg1Of addition,to
R7531 T13818 T13819 arg1Of PDTC,and
R7532 T13819 T13817 arg2Of and,to
R7533 T13820 T13819 arg2Of LY294002,and
R7534 T13824 T13821 arg2Of pattern,showed
R7535 T13824 T13822 arg1Of pattern,the
R7536 T13824 T13823 arg1Of pattern,same
R7537 T13824 T13825 arg1Of pattern,of
R7538 T13826 T13825 arg2Of inhibition,of
R7539 T13828 T13827 arg1Of effects,Cytotoxic
R7540 T13828 T13829 arg1Of effects,on
R7541 T13828 T13838 arg1Of effects,were
R7542 T13828 T13840 arg2Of effects,observed
R7543 T13830 T13829 arg2Of PBMC,on
R7544 T13830 T13831 arg1Of PBMC,by
R7545 T13830 T13835 arg1Of PBMC,at
R7546 T13834 T13831 arg2Of inhibitors,by
R7547 T13834 T13832 arg1Of inhibitors,the
R7548 T13834 T13833 arg1Of inhibitors,chemical
R7549 T13837 T13835 arg2Of concentrations,at
R7550 T13837 T13836 arg1Of concentrations,experimental
R7551 T13840 T13838 arg2Of observed,were
R7552 T13840 T13839 arg1Of observed,not
R7553 T13840 T13841 arg1Of observed,(
R7554 T13843 T13841 arg2Of 4b,(
R7555 T13843 T13842 arg1Of 4b,Fig.
R7556 T13844 T13841 arg3Of ),(
R7980 T14508 T14506 arg1Of expression,IL-17
R7981 T14508 T14507 arg1Of expression,mRNA
R7982 T14508 T14509 arg1Of expression,in
R7983 T14511 T14509 arg2Of PBMC,in
R7984 T14511 T14510 arg1Of PBMC,RA
R7985 T14513 T14512 arg1Of see,To
R7986 T14517 T14515 arg2Of production,enhanced
R7987 T14517 T14516 arg1Of production,IL-17
R7988 T14517 T14518 arg1Of production,could
R7989 T14517 T14519 arg1Of production,be
R7990 T14517 T14520 arg2Of production,regulated
R7991 T14520 T14513 arg2Of regulated,see
R7992 T14520 T14514 arg1Of regulated,whether
R7993 T14520 T14518 arg2Of regulated,could
R7994 T14520 T14519 arg2Of regulated,be
R7995 T14520 T14521 arg1Of regulated,at
R7996 T14524 T14521 arg2Of level,at
R7997 T14524 T14522 arg1Of level,a
R7998 T14524 T14523 arg1Of level,transcriptional
R7999 T14530 T14526 arg1Of reaction,semi-quantatitive
R8000 T14530 T14527 arg1Of reaction,reverse
R8001 T14530 T14528 arg1Of reaction,transcription–polymerase
R8002 T14530 T14529 arg1Of reaction,chain
R8003 T14530 T14531 arg1Of reaction,was
R8004 T14530 T14532 arg2Of reaction,performed
R8005 T14532 T14512 modOf performed,To
R8006 T14532 T14525 arg1Of performed,","
R8007 T14532 T14531 arg2Of performed,was
R8008 T14533 T14534 arg1Of We,observed
R8009 T14534 T14542 arg1Of observed,after
R8010 T14534 T14546 arg1Of observed,;
R8011 T14537 T14534 arg2Of increase,observed
R8012 T14537 T14535 arg1Of increase,a
R8013 T14537 T14536 arg1Of increase,dose-dependent
R8014 T14537 T14538 arg1Of increase,in
R8015 T14541 T14538 arg2Of transcripts,in
R8016 T14541 T14539 arg1Of transcripts,IL-17
R8017 T14541 T14540 arg1Of transcripts,mRNA
R8018 T14543 T14542 arg2Of stimulation,after
R8019 T14543 T14544 arg1Of stimulation,with
R8020 T14545 T14544 arg2Of anti-CD3,with
R8021 T14547 T14548 arg1Of this,was
R8022 T14547 T14549 arg2Of this,inhibited
R8023 T14549 T14546 arg2Of inhibited,;
R8024 T14549 T14548 arg2Of inhibited,was
R8025 T14549 T14550 arg1Of inhibited,by
R8026 T14549 T14556 arg1Of inhibited,by
R8027 T14549 T14561 arg1Of inhibited,(
R8028 T14550 T14555 arg1Of by,and
R8029 T14554 T14550 arg2Of LY294002,by
R8030 T14554 T14551 arg1Of LY294002,the
R8031 T14554 T14552 arg1Of LY294002,PI3K
R8032 T14554 T14553 arg1Of LY294002,inhibitor
R8033 T14556 T14555 arg2Of by,and
R8034 T14560 T14556 arg2Of PDTC,by
R8035 T14560 T14557 arg1Of PDTC,the
R8036 T14560 T14558 arg1Of PDTC,NF-κB
R8037 T14560 T14559 arg1Of PDTC,inhibitor
R8038 T14562 T14561 arg2Of Fig.,(
R8039 T14562 T14563 arg1Of Fig.,5
R8040 T14564 T14561 arg3Of ),(
R8171 T14971 T14972 arg1Of Activation,of
R8172 T14971 T14977 arg1Of Activation,on
R8173 T14971 T14980 arg1Of Activation,by
R8174 T14976 T14972 arg2Of pathway,of
R8175 T14976 T14973 arg1Of pathway,PI3K/Akt
R8176 T14976 T14974 arg1Of pathway,signal
R8177 T14976 T14975 arg1Of pathway,transduction
R8178 T14979 T14977 arg2Of production,on
R8179 T14979 T14978 arg1Of production,IL-17
R8180 T14981 T14980 arg2Of anti-CD3,by
R8181 T14983 T14982 arg1Of determine,To
R8182 T14986 T14983 arg2Of molecules,determine
R8183 T14986 T14984 arg1Of molecules,downstream
R8184 T14986 T14985 arg1Of molecules,effector
R8185 T14986 T14987 arg1Of molecules,of
R8186 T14990 T14987 arg2Of pathway,of
R8187 T14990 T14988 arg1Of pathway,the
R8188 T14990 T14989 arg1Of pathway,PI3K
R8189 T14992 T14983 arg1Of we,determine
R8190 T14992 T14993 arg1Of we,evaluated
R8191 T14993 T14982 modOf evaluated,To
R8192 T14993 T14991 arg1Of evaluated,","
R8193 T14995 T14993 arg2Of activation,evaluated
R8194 T14995 T14994 arg1Of activation,the
R8195 T14995 T14996 arg1Of activation,of
R8196 T14995 T14998 arg1Of activation,by
R8197 T14997 T14996 arg2Of Akt,of
R8198 T15000 T14998 arg2Of blotting,by
R8199 T15000 T14999 arg1Of blotting,western
R8200 T15002 T15001 arg2Of shown,As
R8201 T15002 T15003 arg1Of shown,in
R8202 T15002 T15006 arg1Of shown,","
R8203 T15002 T15007 arg1Of shown,at
R8204 T15004 T15003 arg2Of Fig.,in
R8205 T15004 T15005 arg1Of Fig.,6
R8206 T15009 T15007 arg2Of min,at
R8207 T15009 T15008 arg1Of min,10
R8208 T15009 T15010 arg1Of min,of
R8209 T15009 T15012 arg1Of min,with
R8210 T15011 T15010 arg2Of incubation,of
R8211 T15013 T15014 arg1Of anti-CD3,(
R8212 T15013 T15018 arg1Of anti-CD3,or
R8213 T15016 T15014 arg2Of μg/ml,(
R8214 T15016 T15015 arg1Of μg/ml,10
R8215 T15017 T15014 arg3Of ),(
R8216 T15018 T15012 arg2Of or,with
R8217 T15019 T15018 arg2Of LY294002,or
R8218 T15019 T15020 arg1Of LY294002,(
R8219 T15022 T15020 arg2Of μM,(
R8220 T15022 T15021 arg1Of μM,20
R8221 T15023 T15020 arg3Of ),(
R8222 T15026 T15025 arg1Of difference,no
R8223 T15026 T15027 arg1Of difference,in
R8224 T15026 T15033 arg1Of difference,was
R8225 T15026 T15034 arg2Of difference,observed
R8226 T15029 T15027 arg2Of amounts,in
R8227 T15029 T15028 arg1Of amounts,the
R8228 T15029 T15030 arg1Of amounts,of
R8229 T15032 T15030 arg2Of Akt,of
R8230 T15032 T15031 arg2Of Akt,phosphorylated
R8231 T15034 T15001 arg1Of observed,As
R8232 T15034 T15024 arg1Of observed,","
R8233 T15034 T15033 arg2Of observed,was
R8234 T15039 T15037 arg2Of min,after
R8235 T15039 T15038 arg1Of min,30
R8236 T15039 T15040 arg1Of min,of
R8237 T15041 T15040 arg2Of incubation,of
R8238 T15044 T15043 arg2Of Akt,phosphorylated
R8239 T15044 T15045 arg1Of Akt,increased
R8240 T15045 T15046 arg1Of increased,(
R8241 T15045 T15051 arg1Of increased,and
R8242 T15047 T15046 arg2Of lane,(
R8243 T15047 T15048 arg1Of lane,2
R8244 T15049 T15046 arg3Of ),(
R8245 T15051 T15035 arg1Of and,However
R8246 T15051 T15036 arg1Of and,","
R8247 T15051 T15037 arg1Of and,after
R8248 T15051 T15042 arg1Of and,","
R8249 T15051 T15050 arg1Of and,","
R8250 T15053 T15052 arg1Of effect,the
R8251 T15053 T15054 arg1Of effect,of
R8252 T15053 T15056 arg1Of effect,by
R8253 T15053 T15062 arg1Of effect,reached
R8254 T15053 T15069 arg1Of effect,lasting
R8255 T15055 T15054 arg2Of inhibition,of
R8256 T15057 T15056 arg2Of LY294002,by
R8257 T15057 T15058 arg1Of LY294002,(
R8258 T15059 T15058 arg2Of lane,(
R8259 T15059 T15060 arg1Of lane,3
R8260 T15061 T15058 arg3Of ),(
R8261 T15062 T15051 arg2Of reached,and
R8262 T15062 T15065 arg1Of reached,at
R8263 T15062 T15068 arg1Of reached,","
R8264 T15062 T15069 modOf reached,lasting
R8265 T15064 T15062 arg2Of peak,reached
R8266 T15064 T15063 arg1Of peak,a
R8267 T15067 T15065 arg2Of min,at
R8268 T15067 T15066 arg1Of min,60
R8269 T15069 T15070 arg1Of lasting,to
R8270 T15072 T15070 arg2Of min,to
R8271 T15072 T15071 arg1Of min,120–240
R8272 T15074 T15073 arg2Of contrast,In
R8273 T15077 T15078 arg1Of Akt,and
R8274 T15078 T15076 arg1Of and,non-phosphorylated
R8275 T15078 T15080 arg1Of and,remained
R8276 T15078 T15081 arg1Of and,unchanged
R8277 T15079 T15078 arg2Of β-actin,and
R8278 T15080 T15073 arg1Of remained,In
R8279 T15080 T15075 arg1Of remained,","
R8280 T15080 T15082 arg1Of remained,regardless
R8281 T15081 T15080 arg2Of unchanged,remained
R8282 T15082 T15083 arg1Of regardless,of
R8283 T15085 T15083 arg2Of time,of
R8284 T15085 T15084 arg1Of time,incubation
R8285 T15086 T15087 arg1Of PHA,","
R8286 T15087 T15090 arg1Of ",",and
R8287 T15089 T15087 arg2Of A,","
R8288 T15089 T15088 arg1Of A,concanavalin
R8289 T15090 T15093 arg1Of and,demonstrated
R8290 T15091 T15090 arg2Of IL-15,and
R8291 T15093 T15092 arg1Of demonstrated,also
R8292 T15093 T15097 arg1Of demonstrated,on
R8293 T15093 T15100 arg1Of demonstrated,as
R8294 T15093 T15104 arg1Of demonstrated,","
R8295 T15093 T15105 arg1Of demonstrated,which
R8296 T15093 T15106 arg1Of demonstrated,was
R8297 T15096 T15093 arg2Of effect,demonstrated
R8298 T15096 T15094 arg1Of effect,the
R8299 T15096 T15095 arg1Of effect,same
R8300 T15099 T15097 arg2Of Akt,on
R8301 T15099 T15098 arg2Of Akt,phosphorylated
R8302 T15101 T15100 arg2Of shown,as
R8303 T15101 T15102 arg1Of shown,with
R8304 T15103 T15102 arg2Of anti-CD3,with
R8305 T15106 T15109 arg1Of was,by
R8306 T15106 T15116 arg1Of was,by
R8307 T15108 T15106 arg2Of inhibition,was
R8308 T15108 T15107 arg1Of inhibition,an
R8309 T15109 T15115 arg1Of by,as
R8310 T15110 T15111 arg1Of wortmannin,and
R8311 T15111 T15109 arg2Of and,by
R8312 T15112 T15111 arg2Of PDTC,and
R8313 T15115 T15113 arg1Of as,as
R8314 T15115 T15114 arg1Of as,well
R8315 T15116 T15115 arg2Of by,as
R8316 T15117 T15116 arg2Of LY294002,by
R8317 T15117 T15118 arg1Of LY294002,(
R8318 T15119 T15118 arg2Of data,(
R8319 T15119 T15121 arg2Of data,shown
R8320 T15121 T15120 arg1Of shown,not
R8321 T15122 T15118 arg3Of ),(
R8583 T15893 T15894 arg1Of Activation,of
R8584 T15893 T15904 arg1Of Activation,in
R8585 T15896 T15897 arg1Of NF-κB,and
R8586 T15899 T15897 arg2Of protein-1,and
R8587 T15899 T15898 arg1Of protein-1,activator
R8588 T15899 T15900 arg1Of protein-1,(
R8589 T15901 T15900 arg2Of AP-1,(
R8590 T15902 T15900 arg3Of ),(
R8591 T15903 T15894 arg2Of pathway,of
R8592 T15903 T15895 arg1Of pathway,the
R8593 T15903 T15896 arg1Of pathway,NF-κB
R8594 T15903 T15899 arg1Of pathway,protein-1
R8595 T15908 T15904 arg2Of region,in
R8596 T15908 T15905 arg1Of region,the
R8597 T15908 T15906 arg1Of region,IL-17
R8598 T15908 T15907 arg1Of region,promoter
R8599 T15910 T15909 arg1Of investigate,To
R8600 T15910 T15911 arg1Of investigate,further
R8601 T15915 T15910 arg2Of pathway,investigate
R8602 T15915 T15912 arg1Of pathway,the
R8603 T15915 T15913 arg1Of pathway,intracellular
R8604 T15915 T15914 arg1Of pathway,signaling
R8605 T15915 T15916 arg2Of pathway,activated
R8606 T15915 T15930 arg1Of pathway,responsible
R8607 T15916 T15929 arg1Of activated,and
R8608 T15918 T15919 arg1Of anti-CD3,plus
R8609 T15919 T15921 arg1Of plus,","
R8610 T15920 T15919 arg2Of anti-CD28,plus
R8611 T15921 T15924 arg1Of ",",","
R8612 T15923 T15921 arg2Of A,","
R8613 T15923 T15922 arg1Of A,concanavalin
R8614 T15924 T15926 arg1Of ",",and
R8615 T15925 T15924 arg2Of PHA,","
R8616 T15926 T15916 arg1Of and,activated
R8617 T15926 T15917 arg2Of and,by
R8618 T15927 T15926 arg2Of IL-15,and
R8619 T15929 T15928 arg1Of and,","
R8620 T15930 T15929 arg2Of responsible,and
R8621 T15930 T15931 arg1Of responsible,for
R8622 T15932 T15931 arg2Of inducing,for
R8623 T15934 T15932 arg2Of expression,inducing
R8624 T15934 T15933 arg1Of expression,IL-17
R8625 T15936 T15937 arg1Of we,performed
R8626 T15937 T15909 modOf performed,To
R8627 T15937 T15935 arg1Of performed,","
R8628 T15941 T15937 arg2Of assay,performed
R8629 T15941 T15938 arg1Of assay,an
R8630 T15941 T15939 arg1Of assay,electrophoretic
R8631 T15941 T15940 arg1Of assay,mobility-shift
R8632 T15941 T15942 arg1Of assay,(
R8633 T15941 T15945 arg1Of assay,of
R8634 T15943 T15942 arg2Of EMSA,(
R8635 T15944 T15942 arg3Of ),(
R8636 T15948 T15945 arg2Of sites,of
R8637 T15948 T15946 arg1Of sites,NF-κB
R8638 T15948 T15947 arg1Of sites,recognition
R8639 T15948 T15949 arg1Of sites,in
R8640 T15951 T15949 arg2Of promoters,in
R8641 T15951 T15950 arg1Of promoters,the
R8642 T15951 T15952 arg1Of promoters,of
R8643 T15953 T15952 arg2Of IL-17,of
R8644 T15955 T15954 arg2Of shown,As
R8645 T15955 T15956 arg1Of shown,in
R8646 T15958 T15956 arg2Of 7a,in
R8647 T15958 T15957 arg1Of 7a,Fig.
R8648 T15961 T15960 arg1Of extracts,nuclear
R8649 T15961 T15962 arg1Of extracts,from
R8650 T15961 T15974 arg1Of extracts,demonstrated
R8651 T15964 T15962 arg2Of PBMC,from
R8652 T15964 T15963 arg1Of PBMC,RA
R8653 T15964 T15965 arg2Of PBMC,stimulated
R8654 T15965 T15966 arg1Of stimulated,with
R8655 T15967 T15968 arg1Of anti-CD3,plus
R8656 T15968 T15966 arg2Of plus,with
R8657 T15968 T15970 arg1Of plus,(
R8658 T15969 T15968 arg2Of anti-CD28,plus
R8659 T15971 T15970 arg2Of lane,(
R8660 T15971 T15972 arg1Of lane,2
R8661 T15973 T15970 arg3Of ),(
R8662 T15974 T15954 arg1Of demonstrated,As
R8663 T15974 T15959 arg1Of demonstrated,","
R8664 T15974 T15982 arg1Of demonstrated,in
R8665 T15976 T15974 arg2Of binding,demonstrated
R8666 T15976 T15975 arg2Of binding,increased
R8667 T15976 T15977 arg1Of binding,of
R8668 T15976 T15979 arg1Of binding,to
R8669 T15978 T15977 arg2Of NF-κB,of
R8670 T15981 T15979 arg2Of promoters,to
R8671 T15981 T15980 arg1Of promoters,IL-17
R8672 T15983 T15982 arg2Of comparison,in
R8673 T15983 T15984 arg1Of comparison,with
R8674 T15985 T15984 arg2Of that,with
R8675 T15985 T15986 arg1Of that,of
R8676 T15987 T15986 arg2Of controls,of
R8677 T15987 T15988 arg1Of controls,(
R8678 T15989 T15988 arg2Of lane,(
R8679 T15989 T15990 arg1Of lane,1
R8680 T15991 T15988 arg3Of ),(
R8681 T15994 T15992 arg1Of assay,A
R8682 T15994 T15993 arg1Of assay,supershift
R8683 T15994 T15995 arg1Of assay,demonstrated
R8684 T15995 T16009 arg1Of demonstrated,in
R8685 T15997 T15995 arg2Of bands,demonstrated
R8686 T15997 T15996 arg2Of bands,shifted
R8687 T15997 T15998 arg1Of bands,in
R8688 T15999 T16000 arg1Of p65,and
R8689 T16000 T15998 arg2Of and,in
R8690 T16000 T16002 arg1Of and,(
R8691 T16001 T16000 arg2Of p50,and
R8692 T16004 T16005 arg1Of 3,and
R8693 T16005 T16002 arg2Of and,(
R8694 T16005 T16003 arg1Of and,lanes
R8695 T16006 T16005 arg2Of 4,and
R8696 T16007 T16002 arg3Of ),(
R8697 T16009 T16008 arg1Of in,not
R8698 T16010 T16009 arg2Of c-Rel,in
R8699 T16010 T16011 arg1Of c-Rel,(
R8700 T16012 T16011 arg2Of lane,(
R8701 T16012 T16013 arg1Of lane,5
R8702 T16014 T16011 arg3Of ),(
R8703 T16017 T16015 arg2Of PBMC,In
R8704 T16017 T16016 arg1Of PBMC,normal
R8705 T16020 T16018 arg1Of pattern,the
R8706 T16020 T16019 arg1Of pattern,same
R8707 T16020 T16021 arg1Of pattern,was
R8708 T16020 T16022 arg2Of pattern,observed
R8709 T16022 T16015 arg1Of observed,In
R8710 T16022 T16021 arg2Of observed,was
R8711 T16022 T16024 arg1Of observed,but
R8712 T16024 T16023 arg1Of but,","
R8713 T16026 T16025 arg1Of degree,the
R8714 T16026 T16027 arg1Of degree,of
R8715 T16026 T16030 arg1Of degree,by
R8716 T16026 T16034 arg1Of degree,was
R8717 T16026 T16036 arg1Of degree,intense
R8718 T16029 T16027 arg2Of activation,of
R8719 T16029 T16028 arg1Of activation,NF-κB
R8720 T16031 T16032 arg1Of anti-CD3,plus
R8721 T16032 T16030 arg2Of plus,by
R8722 T16033 T16032 arg2Of anti-CD28,plus
R8723 T16034 T16024 arg2Of was,but
R8724 T16036 T16034 arg2Of intense,was
R8725 T16036 T16035 arg1Of intense,less
R8726 T16036 T16037 arg1Of intense,than
R8727 T16038 T16037 arg2Of that,than
R8728 T16038 T16039 arg1Of that,in
R8729 T16041 T16039 arg2Of PBMC,in
R8730 T16041 T16040 arg1Of PBMC,RA
R8731 T16041 T16042 arg1Of PBMC,(
R8732 T16044 T16042 arg2Of 7b,(
R8733 T16044 T16043 arg1Of 7b,Fig.
R8734 T16045 T16042 arg3Of ),(
R8735 T16047 T16046 arg1Of confirm,To
R8736 T16049 T16047 arg2Of link,confirm
R8737 T16049 T16048 arg1Of link,the
R8738 T16049 T16050 arg1Of link,between
R8739 T16052 T16051 arg1Of activity,PI3K
R8740 T16052 T16053 arg1Of activity,and
R8741 T16053 T16050 arg2Of and,between
R8742 T16054 T16053 arg2Of NF-κB,and
R8743 T16056 T16047 arg1Of we,confirm
R8744 T16056 T16057 arg1Of we,performed
R8745 T16057 T16046 modOf performed,To
R8746 T16057 T16055 arg1Of performed,","
R8747 T16058 T16057 arg2Of EMSA,performed
R8748 T16058 T16059 modOf EMSA,to
R8749 T16060 T16059 arg1Of determine,to
R8750 T16060 T16065 arg1Of determine,after
R8751 T16064 T16060 arg2Of activity,determine
R8752 T16064 T16061 arg1Of activity,the
R8753 T16064 T16062 arg1Of activity,NF-κB
R8754 T16064 T16063 arg1Of activity,binding
R8755 T16066 T16065 arg2Of treatment,after
R8756 T16066 T16067 arg1Of treatment,with
R8757 T16069 T16070 arg1Of LY294002,and
R8758 T16070 T16067 arg2Of and,with
R8759 T16070 T16068 arg1Of and,both
R8760 T16071 T16070 arg2Of PDTC,and
R8761 T16073 T16072 arg1Of agents,Both
R8762 T16073 T16074 arg1Of agents,block
R8763 T16077 T16074 arg2Of activity,block
R8764 T16077 T16075 arg1Of activity,NF-κB
R8765 T16077 T16076 arg1Of activity,DNA-binding
R8766 T16077 T16078 arg1Of activity,in
R8767 T16081 T16078 arg2Of promoter,in
R8768 T16081 T16079 arg1Of promoter,the
R8769 T16081 T16080 arg1Of promoter,IL-17
R8770 T16081 T16082 arg1Of promoter,(
R8771 T16084 T16082 arg2Of 7c,(
R8772 T16084 T16083 arg1Of 7c,Fig.
R8773 T16085 T16082 arg3Of ),(
R8774 T16087 T16086 arg1Of blotting,Western
R8775 T16087 T16088 arg1Of blotting,for
R8776 T16087 T16090 arg1Of blotting,showed
R8777 T16089 T16088 arg2Of IκB-α,for
R8778 T16091 T16090 arg2Of inhibition,showed
R8779 T16091 T16092 arg1Of inhibition,of
R8780 T16093 T16092 arg2Of degradation,of
R8781 T16093 T16094 arg1Of degradation,of
R8782 T16093 T16096 arg1Of degradation,by
R8783 T16093 T16100 arg1Of degradation,at
R8784 T16095 T16094 arg2Of IκB-α,of
R8785 T16097 T16098 arg1Of LY294002,and
R8786 T16098 T16096 arg2Of and,by
R8787 T16099 T16098 arg2Of PDTC,and
R8788 T16103 T16100 arg2Of time,at
R8789 T16103 T16101 arg1Of time,the
R8790 T16103 T16102 arg1Of time,same
R8791 T16103 T16104 arg1Of time,(
R8792 T16106 T16104 arg2Of 7c,(
R8793 T16106 T16105 arg1Of 7c,Fig.
R8794 T16107 T16104 arg3Of ),(
R8795 T16109 T16108 arg2Of contrast,In
R8796 T16113 T16111 arg1Of pathway,the
R8797 T16113 T16112 arg1Of pathway,AP-1
R8798 T16113 T16114 arg1Of pathway,was
R8799 T16113 T16116 arg2Of pathway,activated
R8800 T16116 T16108 arg1Of activated,In
R8801 T16116 T16110 arg1Of activated,","
R8802 T16116 T16114 arg2Of activated,was
R8803 T16116 T16115 arg1Of activated,not
R8804 T16116 T16128 arg1Of activated,","
R8805 T16116 T16129 modOf activated,demonstrating
R8806 T16118 T16116 arg1Of stimulation,activated
R8807 T16118 T16117 arg2Of stimulation,by
R8808 T16118 T16119 arg1Of stimulation,with
R8809 T16120 T16121 arg1Of anti-CD3,plus
R8810 T16122 T16121 arg2Of anti-CD28,plus
R8811 T16124 T16119 arg2Of data,with
R8812 T16124 T16120 arg1Of data,anti-CD3
R8813 T16124 T16122 arg1Of data,anti-CD28
R8814 T16124 T16123 arg2Of data,(
R8815 T16124 T16126 arg2Of data,shown
R8816 T16126 T16125 arg1Of shown,not
R8817 T16127 T16123 arg3Of ),(
R8818 T16131 T16132 arg1Of NF-κB,is
R8819 T16132 T16129 arg2Of is,demonstrating
R8820 T16132 T16130 arg1Of is,that
R8821 T16137 T16132 arg2Of pathway,is
R8822 T16137 T16133 arg1Of pathway,the
R8823 T16137 T16134 arg1Of pathway,main
R8824 T16137 T16135 arg1Of pathway,intracellular
R8825 T16137 T16136 arg1Of pathway,signaling
R8826 T16137 T16138 arg1Of pathway,in
R8827 T16137 T16141 arg1Of pathway,by
R8828 T16140 T16138 arg2Of production,in
R8829 T16140 T16139 arg1Of production,IL-17
R8830 T16143 T16141 arg2Of PBMC,by
R8831 T16143 T16142 arg2Of PBMC,activated
R8832 T16143 T16144 arg1Of PBMC,from
R8833 T16145 T16144 arg2Of patients,from
R8834 T16145 T16146 arg1Of patients,with
R8835 T16147 T16146 arg2Of RA,with
R9423 T18418 T18419 arg1Of IL-17,was
R9424 T18418 T18421 arg2Of IL-17,described
R9425 T18421 T18419 arg2Of described,was
R9426 T18421 T18420 arg1Of described,first
R9427 T18421 T18422 arg1Of described,as
R9428 T18426 T18422 arg2Of product,as
R9429 T18426 T18423 arg1Of product,a
R9430 T18426 T18424 arg1Of product,T
R9431 T18426 T18425 arg1Of product,cell
R9432 T18426 T18427 arg1Of product,with
R9433 T18429 T18427 arg2Of properties,with
R9434 T18429 T18428 arg1Of properties,proinflammatory
R9435 T18429 T18430 arg1Of properties,[
R9436 T18431 T18430 arg2Of "5,22",[
R9437 T18432 T18430 arg3Of ],[
R9438 T18433 T18434 arg1Of RA,is
R9439 T18433 T18435 arg2Of RA,characterized
R9440 T18435 T18434 arg2Of characterized,is
R9441 T18435 T18449 arg1Of characterized,[
R9442 T18437 T18438 arg1Of hyperplasia,of
R9443 T18437 T18442 arg1Of hyperplasia,and
R9444 T18441 T18438 arg2Of cells,of
R9445 T18441 T18439 arg1Of cells,synovial
R9446 T18441 T18440 arg1Of cells,lining
R9447 T18442 T18435 arg1Of and,characterized
R9448 T18442 T18436 arg2Of and,by
R9449 T18445 T18442 arg2Of infiltration,and
R9450 T18445 T18443 arg1Of infiltration,an
R9451 T18445 T18444 arg1Of infiltration,intense
R9452 T18445 T18446 arg1Of infiltration,by
R9453 T18448 T18446 arg2Of cells,by
R9454 T18448 T18447 arg1Of cells,mononuclear
R9455 T18450 T18449 arg2Of 23,[
R9456 T18451 T18449 arg3Of ],[
R9457 T18453 T18452 arg1Of cytokines,Proinflammatory
R9458 T18453 T18455 arg1Of cytokines,as
R9459 T18453 T18459 arg1Of cytokines,are
R9460 T18453 T18460 arg1Of cytokines,abundant
R9461 T18455 T18454 arg1Of as,such
R9462 T18456 T18457 arg1Of IL-1,and
R9463 T18457 T18455 arg2Of and,as
R9464 T18458 T18457 arg2Of TNF-α,and
R9465 T18459 T18465 arg1Of are,whereas
R9466 T18460 T18459 arg2Of abundant,are
R9467 T18460 T18461 arg1Of abundant,in
R9468 T18463 T18461 arg2Of synovium,in
R9469 T18463 T18462 arg1Of synovium,rheumatoid
R9470 T18465 T18464 arg1Of whereas,","
R9471 T18468 T18467 arg1Of cell-derived,T
R9472 T18469 T18466 arg1Of cytokines,the
R9473 T18469 T18468 arg1Of cytokines,cell-derived
R9474 T18469 T18470 arg1Of cytokines,","
R9475 T18469 T18476 arg1Of cytokines,have
R9476 T18469 T18478 arg1Of cytokines,proved
R9477 T18469 T18479 arg1Of cytokines,difficult
R9478 T18469 T18481 arg2Of cytokines,detect
R9479 T18472 T18473 arg1Of IL-4,and
R9480 T18473 T18470 arg2Of and,","
R9481 T18473 T18471 arg1Of and,especially
R9482 T18474 T18473 arg2Of interferon-γ,and
R9483 T18478 T18465 arg2Of proved,whereas
R9484 T18478 T18475 arg1Of proved,","
R9485 T18478 T18476 arg2Of proved,have
R9486 T18478 T18477 arg1Of proved,often
R9487 T18479 T18478 arg2Of difficult,proved
R9488 T18481 T18479 arg2Of detect,difficult
R9489 T18481 T18480 arg1Of detect,to
R9490 T18481 T18482 arg1Of detect,in
R9491 T18481 T18485 arg1Of detect,[
R9492 T18484 T18482 arg2Of synovium,in
R9493 T18484 T18483 arg1Of synovium,RA
R9494 T18486 T18485 arg2Of 24,[
R9495 T18487 T18485 arg3Of ],[
R9496 T18490 T18489 arg1Of cells,T
R9497 T18490 T18491 arg1Of cells,may
R9498 T18490 T18492 arg1Of cells,have
R9499 T18492 T18488 arg2Of have,Although
R9500 T18492 T18491 arg2Of have,may
R9501 T18492 T18495 arg1Of have,in
R9502 T18494 T18492 arg2Of role,have
R9503 T18494 T18493 arg1Of role,a
R9504 T18497 T18495 arg2Of augmentation,in
R9505 T18497 T18496 arg1Of augmentation,the
R9506 T18497 T18498 arg1Of augmentation,of
R9507 T18501 T18498 arg2Of inflammation,of
R9508 T18501 T18499 arg1Of inflammation,rheumatoid
R9509 T18501 T18500 arg1Of inflammation,synovial
R9510 T18504 T18503 arg1Of lack,the
R9511 T18504 T18505 arg1Of lack,of
R9512 T18504 T18509 arg1Of lack,has
R9513 T18504 T18510 arg1Of lack,limited
R9514 T18508 T18505 arg2Of cytokines,of
R9515 T18508 T18506 arg1Of cytokines,T
R9516 T18508 T18507 arg1Of cytokines,cell-derived
R9517 T18510 T18488 arg1Of limited,Although
R9518 T18510 T18502 arg1Of limited,","
R9519 T18510 T18509 arg2Of limited,has
R9520 T18512 T18510 arg2Of importance,limited
R9521 T18512 T18511 arg1Of importance,its
R9522 T18515 T18513 arg2Of respect,In
R9523 T18515 T18514 arg1Of respect,this
R9524 T18517 T18518 arg1Of IL-17,is
R9525 T18517 T18519 arg1Of IL-17,appealing
R9526 T18519 T18513 arg1Of appealing,In
R9527 T18519 T18516 arg1Of appealing,","
R9528 T18519 T18518 arg2Of appealing,is
R9529 T18519 T18520 arg1Of appealing,because
R9530 T18521 T18522 arg1Of it,has
R9531 T18521 T18523 arg1Of it,been
R9532 T18521 T18524 arg2Of it,described
R9533 T18524 T18520 arg2Of described,because
R9534 T18524 T18522 arg2Of described,has
R9535 T18524 T18523 arg2Of described,been
R9536 T18524 T18525 arg1Of described,as
R9537 T18529 T18525 arg2Of cytokine,as
R9538 T18529 T18526 arg1Of cytokine,a
R9539 T18529 T18527 arg1Of cytokine,T
R9540 T18529 T18528 arg1Of cytokine,cell-derived
R9541 T18529 T18530 arg1Of cytokine,with
R9542 T18532 T18530 arg2Of properties,with
R9543 T18532 T18531 arg1Of properties,proinflammatory
R9544 T18535 T18533 arg2Of studies,In
R9545 T18535 T18534 arg1Of studies,our
R9546 T18537 T18538 arg1Of we,tried
R9547 T18537 T18540 arg1Of we,evaluate
R9548 T18538 T18533 arg1Of tried,In
R9549 T18538 T18536 arg1Of tried,","
R9550 T18538 T18550 arg1Of tried,and
R9551 T18540 T18538 arg2Of evaluate,tried
R9552 T18540 T18539 arg1Of evaluate,to
R9553 T18541 T18540 arg2Of how,evaluate
R9554 T18543 T18542 arg1Of production,IL-17
R9555 T18543 T18544 arg1Of production,is
R9556 T18543 T18545 arg2Of production,regulated
R9557 T18545 T18541 arg1Of regulated,how
R9558 T18545 T18544 arg2Of regulated,is
R9559 T18545 T18546 arg1Of regulated,in
R9560 T18548 T18546 arg2Of PBMC,in
R9561 T18548 T18547 arg1Of PBMC,RA
R9562 T18550 T18549 arg1Of and,","
R9563 T18553 T18551 arg1Of pathway,which
R9564 T18553 T18552 arg1Of pathway,signaling
R9565 T18553 T18555 arg2Of pathway,used
R9566 T18554 T18555 arg1Of it,used
R9567 T18555 T18550 arg2Of used,and
R9568 T18556 T18557 arg1Of Levels,of
R9569 T18556 T18559 arg1Of Levels,were
R9570 T18556 T18560 arg2Of Levels,found
R9571 T18556 T18562 arg1Of Levels,be
R9572 T18556 T18563 arg1Of Levels,higher
R9573 T18558 T18557 arg2Of IL-17,of
R9574 T18560 T18559 arg2Of found,were
R9575 T18562 T18560 arg3Of be,found
R9576 T18562 T18561 arg1Of be,to
R9577 T18563 T18562 arg2Of higher,be
R9578 T18563 T18564 arg1Of higher,in
R9579 T18563 T18568 arg1Of higher,than
R9580 T18567 T18564 arg2Of fluid,in
R9581 T18567 T18565 arg1Of fluid,RA
R9582 T18567 T18566 arg1Of fluid,synovial
R9583 T18569 T18568 arg2Of in,than
R9584 T18572 T18569 arg2Of fluid,in
R9585 T18572 T18570 arg1Of fluid,OA
R9586 T18572 T18571 arg1Of fluid,synovial
R9587 T18572 T18573 arg1Of fluid,[
R9588 T18574 T18573 arg2Of 15,[
R9589 T18575 T18573 arg3Of ],[
R9590 T18578 T18579 arg1Of there,are
R9591 T18579 T18576 arg1Of are,However
R9592 T18579 T18577 arg1Of are,","
R9593 T18581 T18579 arg2Of data,are
R9594 T18581 T18580 arg1Of data,few
R9595 T18581 T18582 arg1Of data,available
R9596 T18581 T18586 arg1Of data,that
R9597 T18581 T18587 arg1Of data,stimulate
R9598 T18582 T18583 arg1Of available,on
R9599 T18585 T18583 arg2Of agents,on
R9600 T18585 T18584 arg1Of agents,the
R9601 T18587 T18592 arg1Of stimulate,","
R9602 T18587 T18593 arg1Of stimulate,although
R9603 T18589 T18587 arg2Of production,stimulate
R9604 T18589 T18588 arg1Of production,IL-17
R9605 T18589 T18590 arg1Of production,in
R9606 T18591 T18590 arg2Of RA,in
R9607 T18596 T18594 arg1Of level,the
R9608 T18596 T18595 arg1Of level,highest
R9609 T18596 T18597 arg1Of level,of
R9610 T18596 T18600 arg1Of level,can
R9611 T18596 T18601 arg1Of level,be
R9612 T18596 T18602 arg2Of level,achieved
R9613 T18599 T18597 arg2Of production,of
R9614 T18599 T18598 arg1Of production,IL-17
R9615 T18602 T18593 arg2Of achieved,although
R9616 T18602 T18600 arg2Of achieved,can
R9617 T18602 T18601 arg2Of achieved,be
R9618 T18602 T18609 arg1Of achieved,[
R9619 T18605 T18602 arg1Of stimulation,achieved
R9620 T18605 T18603 arg2Of stimulation,by
R9621 T18605 T18604 arg1Of stimulation,anti-CD3/anti-CD28
R9622 T18605 T18606 arg1Of stimulation,in
R9623 T18608 T18606 arg2Of individuals,in
R9624 T18608 T18607 arg1Of individuals,healthy
R9625 T18610 T18609 arg2Of 25,[
R9626 T18611 T18609 arg3Of ],[
R9627 T18614 T18612 arg2Of experiments,In
R9628 T18614 T18613 arg1Of experiments,our
R9629 T18616 T18617 arg1Of PHA,as
R9630 T18616 T18632 arg1Of PHA,increased
R9631 T18618 T18622 arg1Of mitogens,as
R9632 T18622 T18617 arg2Of as,as
R9633 T18622 T18619 arg1Of as,","
R9634 T18622 T18620 arg1Of as,as
R9635 T18622 T18621 arg1Of as,well
R9636 T18622 T18624 arg1Of as,for
R9637 T18623 T18622 arg2Of anti-CD3/anti-CD28,as
R9638 T18625 T18624 arg2Of signaling,for
R9639 T18625 T18626 arg1Of signaling,through
R9640 T18630 T18626 arg2Of receptor,through
R9641 T18630 T18627 arg1Of receptor,the
R9642 T18630 T18628 arg1Of receptor,T
R9643 T18630 T18629 arg1Of receptor,cell
R9644 T18632 T18612 arg1Of increased,In
R9645 T18632 T18615 arg1Of increased,","
R9646 T18632 T18631 arg1Of increased,","
R9647 T18632 T18638 arg1Of increased,in
R9648 T18634 T18632 arg2Of production,increased
R9649 T18634 T18633 arg1Of production,IL-17
R9650 T18634 T18635 arg1Of production,from
R9651 T18637 T18635 arg2Of PBMC,from
R9652 T18637 T18636 arg1Of PBMC,RA
R9653 T18641 T18638 arg2Of manner,in
R9654 T18641 T18639 arg1Of manner,a
R9655 T18641 T18640 arg1Of manner,dose-dependent
R9656 T18642 T18643 arg1Of We,found
R9657 T18643 T18644 arg1Of found,","
R9658 T18643 T18645 arg1Of found,by
R9659 T18643 T18655 arg1Of found,","
R9660 T18649 T18645 arg2Of assay,by
R9661 T18649 T18646 arg1Of assay,a
R9662 T18649 T18647 arg1Of assay,cell
R9663 T18649 T18648 arg1Of assay,proliferation
R9664 T18649 T18650 arg1Of assay,(
R9665 T18651 T18650 arg2Of data,(
R9666 T18651 T18653 arg2Of data,shown
R9667 T18653 T18652 arg1Of shown,not
R9668 T18654 T18650 arg3Of ),(
R9669 T18658 T18657 arg1Of upregulation,this
R9670 T18658 T18659 arg1Of upregulation,of
R9671 T18658 T18661 arg1Of upregulation,might
R9672 T18658 T18662 arg1Of upregulation,be
R9673 T18658 T18664 arg1Of upregulation,to
R9674 T18658 T18670 arg1Of upregulation,to
R9675 T18660 T18659 arg2Of IL-17,of
R9676 T18662 T18643 arg2Of be,found
R9677 T18662 T18656 arg1Of be,that
R9678 T18662 T18661 arg2Of be,might
R9679 T18664 T18663 arg1Of to,due
R9680 T18664 T18669 arg1Of to,than
R9681 T18667 T18664 arg2Of activity,to
R9682 T18667 T18665 arg2Of activity,increased
R9683 T18667 T18666 arg1Of activity,cellular
R9684 T18669 T18662 arg2Of than,be
R9685 T18669 T18668 arg1Of than,rather
R9686 T18670 T18669 arg2Of to,than
R9687 T18672 T18670 arg2Of proliferation,to
R9688 T18672 T18671 arg1Of proliferation,cellular
R9689 T18673 T18674 arg1Of IL-17,is
R9690 T18673 T18675 arg2Of IL-17,produced
R9691 T18675 T18674 arg2Of produced,is
R9692 T18675 T18676 arg1Of produced,mainly
R9693 T18675 T18692 arg1Of produced,[
R9694 T18681 T18678 arg2Of cells,activated
R9695 T18681 T18679 arg1Of cells,CD4+
R9696 T18681 T18680 arg1Of cells,T
R9697 T18681 T18682 arg1Of cells,","
R9698 T18681 T18684 arg1Of cells,for
R9699 T18681 T18687 arg1Of cells,","
R9700 T18684 T18683 arg1Of for,especially
R9701 T18686 T18684 arg2Of cells,for
R9702 T18686 T18685 arg1Of cells,Th1/Th0
R9703 T18687 T18675 arg1Of ",",produced
R9704 T18687 T18677 arg2Of ",",by
R9705 T18691 T18687 arg2Of phenotype,","
R9706 T18691 T18688 arg1Of phenotype,not
R9707 T18691 T18689 arg1Of phenotype,the
R9708 T18691 T18690 arg1Of phenotype,Th2
R9709 T18693 T18692 arg2Of 26,[
R9710 T18694 T18692 arg3Of ],[
R9711 T18697 T18698 arg1Of it,can
R9712 T18697 T18700 arg1Of it,be
R9713 T18697 T18701 arg2Of it,produced
R9714 T18701 T18695 arg1Of produced,However
R9715 T18701 T18696 arg1Of produced,","
R9716 T18701 T18698 arg2Of produced,can
R9717 T18701 T18699 arg1Of produced,also
R9718 T18701 T18700 arg2Of produced,be
R9719 T18701 T18706 arg1Of produced,via
R9720 T18705 T18701 arg1Of cells,produced
R9721 T18705 T18702 arg2Of cells,by
R9722 T18705 T18703 arg1Of cells,CD8+
R9723 T18705 T18704 arg1Of cells,T
R9724 T18710 T18706 arg2Of mechanism,via
R9725 T18710 T18707 arg1Of mechanism,an
R9726 T18710 T18708 arg1Of mechanism,IL-23
R9727 T18710 T18709 arg1Of mechanism,triggering
R9728 T18710 T18711 arg1Of mechanism,in
R9729 T18714 T18711 arg2Of infection,in
R9730 T18714 T18712 arg1Of infection,Gram-negative
R9731 T18714 T18713 arg1Of infection,pulmonary
R9732 T18714 T18715 arg1Of infection,[
R9733 T18716 T18715 arg2Of 14,[
R9734 T18717 T18715 arg3Of ],[
R9735 T18719 T18718 arg2Of addition,In
R9736 T18722 T18721 arg1Of production,IL-17
R9737 T18722 T18723 arg1Of production,was
R9738 T18722 T18725 arg2Of production,augmented
R9739 T18725 T18718 arg1Of augmented,In
R9740 T18725 T18720 arg1Of augmented,","
R9741 T18725 T18723 arg2Of augmented,was
R9742 T18725 T18724 arg1Of augmented,significantly
R9743 T18728 T18725 arg1Of cells,augmented
R9744 T18728 T18726 arg2Of cells,by
R9745 T18728 T18727 arg1Of cells,T
R9746 T18728 T18729 arg1Of cells,recognizing
R9747 T18729 T18733 arg1Of recognizing,in
R9748 T18729 T18738 arg1Of recognizing,[
R9749 T18732 T18729 arg2Of collagen,recognizing
R9750 T18732 T18730 arg1Of collagen,type
R9751 T18732 T18731 arg1Of collagen,II
R9752 T18737 T18733 arg2Of model,in
R9753 T18737 T18734 arg1Of model,a
R9754 T18737 T18735 arg1Of model,collagen-induced
R9755 T18737 T18736 arg1Of model,arthritis
R9756 T18739 T18738 arg2Of 27,[
R9757 T18740 T18738 arg3Of ],[
R9758 T18743 T18741 arg1Of interaction,A
R9759 T18743 T18742 arg1Of interaction,complex
R9760 T18743 T18744 arg1Of interaction,between
R9761 T18743 T18750 arg1Of interaction,might
R9762 T18743 T18751 arg1Of interaction,produce
R9763 T18745 T18744 arg2Of cells,between
R9764 T18745 T18746 arg1Of cells,in
R9765 T18749 T18746 arg2Of joints,in
R9766 T18749 T18747 arg1Of joints,inflamed
R9767 T18749 T18748 arg1Of joints,RA
R9768 T18751 T18750 arg2Of produce,might
R9769 T18753 T18751 arg2Of variety,produce
R9770 T18753 T18752 arg1Of variety,a
R9771 T18753 T18754 arg1Of variety,of
R9772 T18756 T18757 arg1Of cytokines,and
R9773 T18757 T18754 arg2Of and,of
R9774 T18757 T18755 arg1Of and,proinflammatory
R9775 T18757 T18759 arg1Of and,","
R9776 T18757 T18760 arg1Of and,which
R9777 T18757 T18762 arg1Of and,activate
R9778 T18758 T18757 arg2Of chemokines,and
R9779 T18762 T18761 arg1Of activate,also
R9780 T18762 T18765 arg1Of activate,in
R9781 T18764 T18762 arg2Of cells,activate
R9782 T18764 T18763 arg1Of cells,other
R9783 T18767 T18765 arg2Of joints,in
R9784 T18767 T18766 arg1Of joints,the
R9785 T18769 T18768 arg2Of example,For
R9786 T18771 T18772 arg1Of IL-17,stimulates
R9787 T18772 T18768 arg1Of stimulates,For
R9788 T18772 T18770 arg1Of stimulates,","
R9789 T18774 T18772 arg2Of synoviocytes,stimulates
R9790 T18774 T18773 arg1Of synoviocytes,rheumatoid
R9791 T18774 T18776 arg1Of synoviocytes,secrete
R9792 T18776 T18772 arg3Of secrete,stimulates
R9793 T18776 T18775 arg1Of secrete,to
R9794 T18778 T18776 arg2Of cytokines,secrete
R9795 T18778 T18777 arg1Of cytokines,several
R9796 T18778 T18780 arg1Of cytokines,as
R9797 T18780 T18779 arg1Of as,such
R9798 T18781 T18782 arg1Of IL-6,","
R9799 T18782 T18784 arg1Of ",",and
R9800 T18783 T18782 arg2Of IL-8,","
R9801 T18784 T18792 arg1Of and,as
R9802 T18788 T18784 arg2Of gene,and
R9803 T18788 T18785 arg1Of gene,tumor
R9804 T18788 T18786 arg1Of gene,necrosis
R9805 T18788 T18787 arg1Of gene,factor-stimulated
R9806 T18788 T18789 arg1Of gene,6
R9807 T18792 T18780 arg2Of as,as
R9808 T18792 T18790 arg1Of as,as
R9809 T18792 T18791 arg1Of as,well
R9810 T18794 T18792 arg2Of E2,as
R9811 T18794 T18793 arg1Of E2,prostaglandin
R9812 T18794 T18796 arg1Of E2,vitro
R9813 T18794 T18797 arg1Of E2,[
R9814 T18796 T18795 arg1Of vitro,in
R9815 T18798 T18797 arg2Of "12,28,29",[
R9816 T18799 T18797 arg3Of ],[
R9817 T18800 T18801 arg1Of There,are
R9818 T18804 T18802 arg1Of few,as
R9819 T18804 T18803 arg1Of few,yet
R9820 T18805 T18801 arg2Of data,are
R9821 T18805 T18804 arg1Of data,few
R9822 T18805 T18806 arg1Of data,available
R9823 T18806 T18807 arg1Of available,on
R9824 T18809 T18807 arg2Of agents,on
R9825 T18809 T18808 arg1Of agents,the
R9826 T18809 T18810 arg1Of agents,that
R9827 T18809 T18811 arg1Of agents,stimulate
R9828 T18811 T18816 arg1Of stimulate,","
R9829 T18811 T18817 arg1Of stimulate,although
R9830 T18813 T18811 arg2Of production,stimulate
R9831 T18813 T18812 arg1Of production,IL-17
R9832 T18813 T18814 arg1Of production,in
R9833 T18815 T18814 arg2Of RA,in
R9834 T18819 T18818 arg1Of cytokines,some
R9835 T18819 T18820 arg1Of cytokines,(
R9836 T18819 T18825 arg1Of cytokines,have
R9837 T18819 T18826 arg1Of cytokines,been
R9838 T18819 T18827 arg2Of cytokines,known
R9839 T18819 T18829 arg1Of cytokines,regulate
R9840 T18821 T18822 arg1Of IL-15,and
R9841 T18822 T18820 arg2Of and,(
R9842 T18823 T18822 arg2Of IL-23,and
R9843 T18824 T18820 arg3Of ),(
R9844 T18827 T18817 arg2Of known,although
R9845 T18827 T18825 arg2Of known,have
R9846 T18827 T18826 arg2Of known,been
R9847 T18829 T18827 arg3Of regulate,known
R9848 T18829 T18828 arg1Of regulate,to
R9849 T18829 T18832 arg1Of regulate,[
R9850 T18831 T18829 arg2Of production,regulate
R9851 T18831 T18830 arg1Of production,IL-17
R9852 T18833 T18832 arg2Of "13,14",[
R9853 T18834 T18832 arg3Of ],[
R9854 T18835 T18837 arg1Of We,investigated
R9855 T18837 T18836 arg1Of investigated,therefore
R9856 T18837 T18865 modOf investigated,using
R9857 T18840 T18839 arg1Of vitro,in
R9858 T18841 T18840 arg1Of production,vitro
R9859 T18841 T18842 arg1Of production,of
R9860 T18841 T18844 arg1Of production,in
R9861 T18841 T18857 arg1Of production,as
R9862 T18843 T18842 arg2Of IL-17,of
R9863 T18846 T18844 arg2Of PBMC,in
R9864 T18846 T18845 arg1Of PBMC,RA
R9865 T18846 T18847 arg1Of PBMC,responding
R9866 T18847 T18848 arg1Of responding,to
R9867 T18850 T18848 arg2Of variety,to
R9868 T18850 T18849 arg1Of variety,a
R9869 T18850 T18851 arg1Of variety,of
R9870 T18852 T18853 arg1Of cytokines/chemokines,and
R9871 T18853 T18851 arg2Of and,of
R9872 T18854 T18853 arg2Of mitogens,and
R9873 T18857 T18837 arg2Of as,investigated
R9874 T18857 T18838 arg1Of as,the
R9875 T18857 T18855 arg1Of as,as
R9876 T18857 T18856 arg1Of as,well
R9877 T18860 T18858 arg1Of receptor,T
R9878 T18860 T18859 arg1Of receptor,cell
R9879 T18860 T18861 arg1Of receptor,(
R9880 T18862 T18861 arg2Of TCR,(
R9881 T18863 T18861 arg3Of ),(
R9882 T18864 T18857 arg2Of ligation,as
R9883 T18864 T18860 arg1Of ligation,receptor
R9884 T18866 T18865 arg2Of anti-CD3/anti-CD28,using
R9885 T18868 T18867 arg1Of studies,Our
R9886 T18868 T18869 arg1Of studies,demonstrated
R9887 T18871 T18872 arg1Of IL-15,and
R9888 T18872 T18876 arg1Of and,as
R9889 T18873 T18872 arg2Of MCP-1,and
R9890 T18876 T18874 arg1Of as,as
R9891 T18876 T18875 arg1Of as,well
R9892 T18876 T18880 arg1Of as,increased
R9893 T18878 T18876 arg2Of ligation,as
R9894 T18878 T18877 arg1Of ligation,TCR
R9895 T18880 T18869 arg2Of increased,demonstrated
R9896 T18880 T18870 arg1Of increased,that
R9897 T18880 T18879 arg1Of increased,significantly
R9898 T18882 T18880 arg2Of production,increased
R9899 T18882 T18881 arg1Of production,the
R9900 T18882 T18883 arg1Of production,of
R9901 T18882 T18885 arg1Of production,in
R9902 T18884 T18883 arg2Of IL-17,of
R9903 T18887 T18885 arg2Of PBMC,in
R9904 T18887 T18886 arg1Of PBMC,RA
R9905 T18889 T18890 arg1Of IL-15,or
R9906 T18890 T18888 arg1Of or,Adding
R9907 T18890 T18892 arg1Of or,to
R9908 T18890 T18895 arg1Of or,augmented
R9909 T18891 T18890 arg2Of MCP-1,or
R9910 T18894 T18892 arg2Of ligation,to
R9911 T18894 T18893 arg1Of ligation,TCR
R9912 T18895 T18899 arg1Of augmented,markedly
R9913 T18897 T18895 arg2Of production,augmented
R9914 T18897 T18896 arg1Of production,IL-17
R9915 T18899 T18898 arg1Of markedly,more
R9916 T18901 T18900 arg2Of contrast,In
R9917 T18903 T18904 arg1Of IL-1,and
R9918 T18904 T18906 arg1Of and,","
R9919 T18904 T18907 arg1Of and,which
R9920 T18904 T18908 arg1Of and,are
R9921 T18904 T18909 arg2Of and,known
R9922 T18904 T18911 arg1Of and,have
R9923 T18904 T18916 arg1Of and,be
R9924 T18904 T18917 arg2Of and,increased
R9925 T18904 T18922 arg1Of and,did
R9926 T18904 T18924 arg1Of and,affect
R9927 T18905 T18904 arg2Of TNF-α,and
R9928 T18909 T18908 arg2Of known,are
R9929 T18911 T18910 arg1Of have,to
R9930 T18911 T18914 arg1Of have,and
R9931 T18913 T18911 arg2Of properties,have
R9932 T18913 T18912 arg1Of properties,proinflammatory
R9933 T18914 T18909 arg3Of and,known
R9934 T18917 T18914 arg2Of increased,and
R9935 T18917 T18915 arg1Of increased,to
R9936 T18917 T18916 arg2Of increased,be
R9937 T18917 T18918 arg1Of increased,in
R9938 T18920 T18918 arg2Of joints,in
R9939 T18920 T18919 arg1Of joints,RA
R9940 T18924 T18900 arg1Of affect,In
R9941 T18924 T18902 arg1Of affect,","
R9942 T18924 T18921 arg1Of affect,","
R9943 T18924 T18922 arg2Of affect,did
R9944 T18924 T18923 arg1Of affect,not
R9945 T18926 T18924 arg2Of production,affect
R9946 T18926 T18925 arg1Of production,IL-17
R9947 T18928 T18927 arg1Of data,Our
R9948 T18928 T18929 arg1Of data,were
R9949 T18928 T18930 arg1Of data,consistent
R9950 T18930 T18929 arg2Of consistent,were
R9951 T18930 T18931 arg1Of consistent,with
R9952 T18934 T18931 arg2Of report,with
R9953 T18934 T18932 arg1Of report,a
R9954 T18934 T18933 arg1Of report,recent
R9955 T18936 T18937 arg1Of IL-15,triggered
R9956 T18937 T18945 arg1Of triggered,but
R9957 T18939 T18938 arg1Of vitro,in
R9958 T18941 T18937 arg2Of production,triggered
R9959 T18941 T18939 arg1Of production,vitro
R9960 T18941 T18940 arg1Of production,IL-17
R9961 T18941 T18942 arg1Of production,in
R9962 T18943 T18942 arg2Of PBMC,in
R9963 T18945 T18934 arg2Of but,report
R9964 T18945 T18935 arg1Of but,that
R9965 T18945 T18944 arg1Of but,","
R9966 T18946 T18947 arg1Of TNF-α,did
R9967 T18946 T18949 arg1Of TNF-α,do
R9968 T18946 T18950 arg1Of TNF-α,so
R9969 T18949 T18945 arg2Of do,but
R9970 T18949 T18947 arg2Of do,did
R9971 T18949 T18948 arg1Of do,not
R9972 T18949 T18951 arg1Of do,[
R9973 T18950 T18949 arg2Of so,do
R9974 T18952 T18951 arg2Of 13,[
R9975 T18953 T18951 arg3Of ],[
R9976 T18955 T18956 arg1Of there,were
R9977 T18956 T18954 arg2Of were,Although
R9978 T18958 T18956 arg2Of data,were
R9979 T18958 T18957 arg1Of data,no
R9980 T18958 T18959 arg1Of data,that
R9981 T18960 T18962 arg1Of MCP-1,induces
R9982 T18962 T18959 arg2Of induces,that
R9983 T18962 T18961 arg1Of induces,directly
R9984 T18965 T18962 arg2Of activation,induces
R9985 T18965 T18963 arg1Of activation,T
R9986 T18965 T18964 arg1Of activation,cell
R9987 T18967 T18968 arg1Of it,might
R9988 T18967 T18969 arg1Of it,exert
R9989 T18969 T18954 arg1Of exert,Although
R9990 T18969 T18966 arg1Of exert,","
R9991 T18969 T18968 arg2Of exert,might
R9992 T18969 T18971 arg1Of exert,indirectly
R9993 T18969 T18972 arg1Of exert,on
R9994 T18969 T18975 arg1Of exert,through
R9995 T18970 T18969 arg2Of effects,exert
R9996 T18974 T18972 arg2Of cells,on
R9997 T18974 T18973 arg1Of cells,T
R9998 T18977 T18975 arg2Of activation,through
R9999 T18977 T18976 arg1Of activation,the