Id |
Subject |
Object |
Predicate |
Lexical cue |
T1 |
0-19 |
Disease |
denotes |
Parkinson's Disease |
T2 |
31-36 |
Gene |
denotes |
LRRK2 |
T3 |
56-62 |
Var |
denotes |
Mutant |
T4 |
63-71 |
NegReg |
denotes |
Disrupts |
T5 |
72-128 |
MPA |
denotes |
Synaptic Vesicle Trafficking in Ventral Midbrain Neurons |
T6 |
434-439 |
Gene |
denotes |
LRRK2 |
T7 |
440-447 |
Var |
denotes |
mutants |
T9 |
448-458 |
Reg |
denotes |
contribute |
T8 |
462-482 |
MPA |
denotes |
nigral vulnerability |
T11 |
537-545 |
Var |
denotes |
mutation |
T12 |
546-551 |
Gene |
denotes |
LRRK2 |
T10 |
559-566 |
NegReg |
denotes |
impairs |
T13 |
567-636 |
MPA |
denotes |
SV endocytosis in ventral midbrain (MB) neurons, including DA neurons |
T15 |
975-985 |
NegReg |
denotes |
impairment |
T16 |
989-1014 |
MPA |
denotes |
SV endocytosis in neurons |
T17 |
1037-1045 |
Var |
denotes |
deletion |
T14 |
1049-1054 |
Gene |
denotes |
SYNJ1 |
T18 |
1130-1138 |
Var |
denotes |
SYNJ1+/- |
T19 |
1143-1155 |
Var |
denotes |
LRRK2 G2019S |
T20 |
1195-1202 |
NegReg |
denotes |
impairs |
T21 |
1203-1237 |
MPA |
denotes |
sustained exocytosis in MB neurons |
T22 |
1242-1248 |
Reg |
denotes |
alters |
T23 |
1249-1273 |
MPA |
denotes |
specific motor functions |
T24 |
1327-1332 |
Var |
denotes |
LRRK2 |
T25 |
1381-1393 |
Reg |
denotes |
resulting in |
T26 |
1398-1476 |
MPA |
denotes |
disruption of endophilin-synaptojanin1 interaction required for SV endocytosis |
T31 |
2027-2035 |
PosReg |
denotes |
enhanced |
T32 |
2036-2051 |
MPA |
denotes |
kinase activity |
T28 |
2085-2091 |
Var |
denotes |
G2019S |
T29 |
2104-2109 |
Gene |
denotes |
LRRK2 |
T39 |
2177-2182 |
Gene |
denotes |
LRRK2 |
T33 |
2183-2189 |
Var |
denotes |
G2019S |
T34 |
2194-2199 |
Gene |
denotes |
SYNJ1 |
T35 |
2200-2216 |
NegReg |
denotes |
loss of function |
T36 |
2255-2297 |
MPA |
denotes |
deregulating DAergic neuron SV endocytosis |
T37 |
2312-2331 |
Reg |
denotes |
play additive roles |
T38 |
2385-2387 |
Disease |
denotes |
PD |
R1 |
T2 |
T3 |
ThemeOf |
LRRK2,Mutant |
R10 |
T13 |
T10 |
ThemeOf |
"SV endocytosis in ventral midbrain (MB) neurons, including DA neurons",impairs |
R11 |
T14 |
T17 |
ThemeOf |
SYNJ1,deletion |
R12 |
T17 |
T15 |
CauseOf |
deletion,impairment |
R13 |
T16 |
T15 |
ThemeOf |
SV endocytosis in neurons,impairment |
R14 |
T18 |
T20 |
CauseOf |
SYNJ1+/-,impairs |
R15 |
T21 |
T20 |
ThemeOf |
sustained exocytosis in MB neurons,impairs |
R16 |
T19 |
T20 |
CauseOf |
LRRK2 G2019S,impairs |
R17 |
T18 |
T22 |
CauseOf |
SYNJ1+/-,alters |
R18 |
T19 |
T22 |
CauseOf |
LRRK2 G2019S,alters |
R19 |
T23 |
T22 |
ThemeOf |
specific motor functions,alters |
R2 |
T3 |
T4 |
CauseOf |
Mutant,Disrupts |
R20 |
T28 |
T31 |
CauseOf |
G2019S,enhanced |
R21 |
T32 |
T31 |
ThemeOf |
kinase activity,enhanced |
R22 |
T29 |
T28 |
ThemeOf |
LRRK2,G2019S |
R23 |
T33 |
T35 |
CauseOf |
G2019S,loss of function |
R24 |
T34 |
T35 |
CauseOf |
SYNJ1,loss of function |
R25 |
T36 |
T35 |
ThemeOf |
deregulating DAergic neuron SV endocytosis,loss of function |
R26 |
T34 |
T37 |
CauseOf |
SYNJ1,play additive roles |
R27 |
T33 |
T37 |
CauseOf |
G2019S,play additive roles |
R28 |
T38 |
T37 |
ThemeOf |
PD,play additive roles |
R29 |
T24 |
T25 |
CauseOf |
LRRK2,resulting in |
R3 |
T5 |
T4 |
ThemeOf |
Synaptic Vesicle Trafficking in Ventral Midbrain Neurons,Disrupts |
R30 |
T26 |
T25 |
ThemeOf |
disruption of endophilin-synaptojanin1 interaction required for SV endocytosis,resulting in |
R31 |
T39 |
T33 |
ThemeOf |
LRRK2,G2019S |
R4 |
T3 |
T1 |
CauseOf |
Mutant,Parkinson's Disease |
R5 |
T6 |
T7 |
ThemeOf |
LRRK2,mutants |
R6 |
T7 |
T9 |
CauseOf |
mutants,contribute |
R7 |
T8 |
T9 |
ThemeOf |
nigral vulnerability,contribute |
R8 |
T12 |
T11 |
ThemeOf |
LRRK2,mutation |
R9 |
T11 |
T10 |
CauseOf |
mutation,impairs |