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PubMed 16371368 Effects of a leukemia-associated gain-of-function mutation of SHP-2 phosphatase on interleukin-3 signaling. Mutations in SHP-2 phosphatase that cause hyperactivation of its catalytic activity have bee 2.24 KB 2019-09-23 56 52
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PubMed 17435236 Genetic modifiers of the Drosophila blue cheese gene link defects in lysosomal transport with decreased life span and altered ubiquitinated-protein profiles. Defects in lysosomal trafficking pathways 1.58 KB 2019-09-23 31 26
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PubMed 18031991 Isolation and characterization of a novel human RGS mutant displaying gain-of-function activity. Regulator of G protein signaling (RGS) proteins play a crucial role in the adaptation of cells to stimu 1.65 KB 2019-09-23 33 43
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PubMed 18594199 Conditional RNA interference in vivo to study mutant p53 oncogenic gain of function on tumor malignancy. Mutant p53 proteins are thought to have acquired a "gain of function" (GOF) activity that mainl 1.24 KB 2019-09-23 29 42
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PubMed 19338054 Identification and functional analysis of novel variants of the human melanocortin 1 receptor found in melanoma patients. The melanocortin 1 receptor, a Gs protein-coupled receptor expressed in epider 1.9 KB 2019-09-23 33 36
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PubMed 19917135 Elevated expression of p53 gain-of-function mutation R175H in endometrial cancer cells can increase the invasive phenotypes by activation of the EGFR/PI3K/AKT pathway. BACKGROUND: p53 is the most comm 1.68 KB 2019-09-23 31 70
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PubMed 20399956 The tyrosine phosphatase Shp2 in development and cancer. Deregulation of signaling pathways, through mutation or other molecular changes, can ultimately result in disease. The tyrosine phosphatase Shp 1.19 KB 2019-09-23 30 24
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PubMed 20696700 Mutant p53 facilitates somatic cell reprogramming and augments the malignant potential of reprogrammed cells. p53 deficiency enhances the efficiency of somatic cell reprogramming to a pluripotent stat 1.45 KB 2019-09-23 30 70
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PubMed 21175440 The combined impact of CYP2C19 and CYP2B6 pharmacogenetics on cyclophosphamide bioactivation. AIMS: The role of CYP pharmacogenetics in the bioactivation of cyclophosphamide is still controversial. Re 1.69 KB 2019-09-23 29 28
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PubMed 21187651 Mutant p53 R248Q but not R248W enhances in vitro invasiveness of human lung cancer NCI-H1299 cells. More than half of all human cancers are associated with mutations of the TP53 gene. In regard to the 1.87 KB 2019-09-23 31 22
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