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PubMed 24632949 Dysregulation of Wnt inhibitory factor 1 (Wif1) expression resulted in aberrant Wnt-β-catenin signaling and cell death of the cloaca endoderm, and anorectal malformations. In mammalian urorectal devel 2 KB 2019-09-23 33 9
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PubMed 23680148 Mutant p53 prolongs NF-κB activation and promotes chronic inflammation and inflammation-associated colorectal cancer. The tumor suppressor p53 is frequently mutated in human cancer. Common mutant p53 975 Bytes 2019-09-23 36 14
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PubMed 24356649 Spliced MDM2 isoforms promote mutant p53 accumulation and gain-of-function in tumorigenesis. The tumour suppressor p53 is frequently mutated in tumours. Mutant p53 (Mutp53) proteins often gain new act 1.15 KB 2019-09-23 47 17
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PubMed 24373920 Mutant p53 gain of function can be at the root of dedifferentiation of human osteosarcoma MG63 cells into 3AB-OS cancer stem cells. Osteosarcoma is a highly metastatic tumor affecting adolescents, for 2.11 KB 2019-09-23 36 31
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PubMed 20399956 The tyrosine phosphatase Shp2 in development and cancer. Deregulation of signaling pathways, through mutation or other molecular changes, can ultimately result in disease. The tyrosine phosphatase Shp 1.19 KB 2019-09-23 30 24
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PubMed 23460523 Gain-of-function mutations in PDR1, a regulator of antifungal drug resistance in Candida glabrata, control adherence to host cells. Candida glabrata is an emerging opportunistic pathogen that is known 1.47 KB 2019-09-23 32 50
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PubMed 23264849 Gain-of-Function Activity of Mutant p53 in Lung Cancer through Up-Regulation of Receptor Protein Tyrosine Kinase Axl. p53 mutations are present in up to 70% of lung cancer. Cancer cells with p53 mutat 1.7 KB 2019-09-23 31 43
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PubMed 24998848 Mutant p53 gains new function in promoting inflammatory signals by repression of the secreted interleukin-1 receptor antagonist. The TP53 tumor-suppressor gene is frequently mutated in human cancer. M 1.27 KB 2019-09-23 33 23
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PubMed 24730569 Significance of the melanocortin 1 receptor in the DNA damage response of human melanocytes to ultraviolet radiation. Activation of the melanocortin 1 receptor (MC1R) by α-melanocortin (α-MSH) stimula 1.15 KB 2019-09-23 32 9
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PubMed 24946076 PDGF, pericytes and the pathogenesis of idiopathic basal ganglia calcification (IBGC). Platelet-derived growth factors (PDGFs) are important mitogens for various types of mesenchymal cells, and as suc 1.18 KB 2019-09-23 33 24
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