| Id |
Subject |
Object |
Predicate |
Lexical cue |
Negation |
Speculation |
| T802 |
0-7 |
Protein |
denotes |
SHARPIN |
|
|
| T803 |
177-186 |
Negative_regulation |
denotes |
mutations |
|
|
| T804 |
194-201 |
Protein |
denotes |
Sharpin |
|
|
| T805 |
203-249 |
Protein |
denotes |
SHANK-associated RH domain-interacting protein |
|
|
| T806 |
266-272 |
Protein |
denotes |
Rbckl1 |
|
|
| T807 |
274-279 |
Protein |
denotes |
Sipl1 |
|
|
| T808 |
627-634 |
Protein |
denotes |
SHARPIN |
|
|
| T809 |
635-644 |
Negative_regulation |
denotes |
deficient |
|
|
| T810 |
749-756 |
Protein |
denotes |
SHARPIN |
|
|
| T811 |
758-768 |
Negative_regulation |
denotes |
deficiency |
|
|
| T812 |
1053-1057 |
Protein |
denotes |
CD40 |
|
|
| T813 |
1059-1063 |
Protein |
denotes |
CD80 |
|
|
| T814 |
1069-1073 |
Protein |
denotes |
CD86 |
|
|
| T815 |
1095-1102 |
Protein |
denotes |
SHARPIN |
|
|
| T816 |
1103-1112 |
Negative_regulation |
denotes |
deficient |
|
|
| T817 |
1122-1129 |
Negative_regulation |
denotes |
reduced |
|
|
| T818 |
1122-1129 |
Negative_regulation |
denotes |
reduced |
|
|
| T819 |
1122-1129 |
Negative_regulation |
denotes |
reduced |
|
|
| T820 |
1122-1129 |
Negative_regulation |
denotes |
reduced |
|
|
| T821 |
1130-1143 |
Transcription |
denotes |
transcription |
|
|
| T822 |
1130-1143 |
Transcription |
denotes |
transcription |
|
|
| T823 |
1148-1157 |
Gene_expression |
denotes |
secretion |
|
|
| T824 |
1148-1157 |
Gene_expression |
denotes |
secretion |
|
|
| T825 |
1188-1191 |
Protein |
denotes |
IL6 |
|
|
| T826 |
1202-1207 |
Protein |
denotes |
GMCSF |
|
|
| T827 |
1296-1301 |
Protein |
denotes |
MAPK1 |
|
|
| T828 |
1302-1303 |
Protein |
denotes |
3 |
|
|
| T829 |
1305-1309 |
Protein |
denotes |
ERK1 |
|
|
| T830 |
1310-1311 |
Protein |
denotes |
2 |
|
|
| T831 |
1317-1323 |
Protein |
denotes |
MAPK11 |
|
|
| T832 |
1324-1326 |
Protein |
denotes |
12 |
|
|
| T833 |
1327-1329 |
Protein |
denotes |
13 |
|
|
| T834 |
1330-1332 |
Protein |
denotes |
14 |
|
|
| T835 |
1363-1367 |
Protein |
denotes |
TBK1 |
|
|
| T836 |
1592-1596 |
Negative_regulation |
denotes |
loss |
|
|
| T837 |
1600-1607 |
Protein |
denotes |
Sharpin |
|
|
| T2107 |
1771-1778 |
Protein |
denotes |
SHARPIN |
|
|
| T2108 |
1908-1917 |
Gene_expression |
denotes |
expressed |
|
|
| T2109 |
1970-1989 |
Negative_regulation |
denotes |
recessive mutations |
|
|
| T2110 |
1997-2004 |
Protein |
denotes |
Sharpin |
|
|
| T2111 |
2152-2161 |
Positive_regulation |
denotes |
resulting |
|
|
| T2112 |
2152-2161 |
Positive_regulation |
denotes |
resulting |
|
|
| T2113 |
2175-2186 |
Negative_regulation |
denotes |
termination |
|
|
| T2114 |
2195-2204 |
Transcription |
denotes |
synthesis |
|
|
| T2115 |
2209-2216 |
Negative_regulation |
denotes |
absence |
|
|
| T2116 |
2866-2875 |
Negative_regulation |
denotes |
decreased |
|
|
| T2117 |
2876-2885 |
Gene_expression |
denotes |
secretion |
|
|
| T2118 |
2889-2893 |
Protein |
denotes |
IFNγ |
|
|
| T2119 |
3088-3102 |
Negative_regulation |
denotes |
Neutralization |
|
|
| T2120 |
3106-3109 |
Protein |
denotes |
IL5 |
|
|
| T2121 |
3148-3151 |
Protein |
denotes |
IL5 |
|
|
| T2122 |
3152-3161 |
Negative_regulation |
denotes |
deficient |
|
|
| T2123 |
3341-3348 |
Protein |
denotes |
SHARPIN |
|
|
| T2124 |
3445-3449 |
Protein |
denotes |
TNFα |
|
|
| T2125 |
3493-3500 |
Protein |
denotes |
SHARPIN |
|
|
| T2126 |
3501-3510 |
Negative_regulation |
denotes |
deficient |
|
|
| T2127 |
3563-3567 |
Protein |
denotes |
TNFα |
|
|
| T2128 |
4215-4222 |
Protein |
denotes |
SHARPIN |
|
|
| T2129 |
4223-4232 |
Negative_regulation |
denotes |
deficient |
|
|
| T2130 |
4276-4280 |
Negative_regulation |
denotes |
lack |
|
|
| T2131 |
4284-4291 |
Protein |
denotes |
SHARPIN |
|
|
| T2132 |
4569-4576 |
Protein |
denotes |
SHARPIN |
|
|
| T2133 |
4668-4675 |
Protein |
denotes |
SHARPIN |
|
|
| T2134 |
4676-4685 |
Negative_regulation |
denotes |
deficient |
|
|
| T2753 |
4755-4762 |
Protein |
denotes |
Sharpin |
|
|
| T2754 |
4777-4784 |
Protein |
denotes |
SHARPIN |
|
|
| T2755 |
4936-4943 |
Protein |
denotes |
SHARPIN |
|
|
| T2756 |
5150-5157 |
Protein |
denotes |
SHARPIN |
|
|
| T2757 |
5214-5221 |
Protein |
denotes |
SHARPIN |
|
|
| T2758 |
5284-5293 |
Negative_regulation |
denotes |
mutations |
|
|
| T2759 |
5307-5314 |
Protein |
denotes |
Sharpin |
|
|
| T2760 |
5524-5534 |
Transcription |
denotes |
expression |
|
|
| T2761 |
5538-5545 |
Protein |
denotes |
Sharpin |
|
|
| T2762 |
5678-5685 |
Protein |
denotes |
Sharpin |
|
|
| T2763 |
5695-5702 |
Transcription |
denotes |
present |
|
|
| T2764 |
5771-5780 |
Negative_regulation |
denotes |
decreased |
|
|
| T2765 |
5825-5834 |
Negative_regulation |
denotes |
reduction |
|
|
| T2766 |
5838-5845 |
Protein |
denotes |
Sharpin |
|
|
| T2767 |
5924-5931 |
Protein |
denotes |
Sharpin |
|
|
| T2768 |
5993-6004 |
Entity |
denotes |
cytoplasmic |
|
|
| T2769 |
6005-6017 |
Localization |
denotes |
localization |
|
|
| T2770 |
6025-6032 |
Protein |
denotes |
SHARPIN |
|
|
| T13238 |
6129-6136 |
Protein |
denotes |
SHARPIN |
|
|
| T13239 |
6355-6362 |
Protein |
denotes |
SHARPIN |
|
|
| T13240 |
6716-6726 |
Transcription |
denotes |
mRNA level |
|
true |
| T13241 |
6730-6737 |
Protein |
denotes |
Sharpin |
|
|
| T13242 |
7007-7014 |
Protein |
denotes |
SHARPIN |
|
|
| T13243 |
7183-7190 |
Protein |
denotes |
SHARPIN |
|
|
| T13244 |
7207-7216 |
Entity |
denotes |
cytoplasm |
|
|
| T13245 |
7217-7226 |
Localization |
denotes |
localized |
|
|
| T3733 |
7401-7408 |
Protein |
denotes |
Sharpin |
|
|
| T3734 |
7409-7417 |
Negative_regulation |
denotes |
mutation |
|
|
| T3735 |
7536-7541 |
Protein |
denotes |
CD11c |
|
|
| T3736 |
7542-7546 |
Protein |
denotes |
CD8α |
|
|
| T3737 |
7552-7557 |
Protein |
denotes |
CD11c |
|
|
| T3738 |
7558-7562 |
Protein |
denotes |
CD8α |
|
|
| T3739 |
7596-7601 |
Protein |
denotes |
CD11c |
|
|
| T3740 |
7602-7608 |
Protein |
denotes |
PDCA-1 |
|
|
| T3741 |
7827-7834 |
Protein |
denotes |
SHARPIN |
|
|
| T3742 |
7835-7845 |
Negative_regulation |
denotes |
deficiency |
|
|
| T3743 |
8162-8169 |
Protein |
denotes |
Sharpin |
|
|
| T3744 |
8170-8178 |
Negative_regulation |
denotes |
mutation |
|
|
| T13792 |
8308-8315 |
Protein |
denotes |
Sharpin |
|
|
| T13793 |
8316-8324 |
Negative_regulation |
denotes |
mutation |
|
|
| T3745 |
9763-9768 |
Protein |
denotes |
CD11c |
|
|
| T3746 |
9830-9834 |
Protein |
denotes |
CD40 |
|
|
| T3747 |
9836-9840 |
Protein |
denotes |
CD80 |
|
|
| T3748 |
9846-9850 |
Protein |
denotes |
CD86 |
|
|
| T3749 |
9856-9860 |
Protein |
denotes |
TLR3 |
|
|
| T3750 |
9861-9867 |
Binding |
denotes |
ligand |
|
|
| T3751 |
9885-9889 |
Protein |
denotes |
TLR4 |
|
|
| T3752 |
9890-9896 |
Binding |
denotes |
ligand |
|
|
| T3753 |
10056-10064 |
Positive_regulation |
denotes |
resulted |
|
|
| T3754 |
10056-10064 |
Positive_regulation |
denotes |
resulted |
|
|
| T3755 |
10056-10064 |
Positive_regulation |
denotes |
resulted |
|
|
| T3756 |
10068-10077 |
Positive_regulation |
denotes |
increased |
|
|
| T3757 |
10068-10077 |
Positive_regulation |
denotes |
increased |
|
|
| T3758 |
10068-10077 |
Positive_regulation |
denotes |
increased |
|
|
| T3759 |
10078-10088 |
Gene_expression |
denotes |
expression |
|
|
| T3760 |
10078-10088 |
Gene_expression |
denotes |
expression |
|
|
| T3761 |
10078-10088 |
Gene_expression |
denotes |
expression |
|
|
| T3762 |
10092-10096 |
Protein |
denotes |
CD40 |
|
|
| T3763 |
10098-10102 |
Protein |
denotes |
CD80 |
|
|
| T3764 |
10108-10112 |
Protein |
denotes |
CD86 |
|
|
| T3765 |
10144-10154 |
Regulation |
denotes |
difference |
true |
|
| T3766 |
10144-10154 |
Regulation |
denotes |
difference |
true |
|
| T3767 |
10144-10154 |
Regulation |
denotes |
difference |
true |
|
| T3768 |
10162-10172 |
Gene_expression |
denotes |
expression |
|
|
| T3769 |
10162-10172 |
Gene_expression |
denotes |
expression |
|
|
| T3770 |
10162-10172 |
Gene_expression |
denotes |
expression |
|
|
| T3771 |
10239-10246 |
Protein |
denotes |
SHARPIN |
|
|
| T3772 |
10247-10257 |
Negative_regulation |
denotes |
deficiency |
|
|
| T4247 |
10426-10434 |
Positive_regulation |
denotes |
resulted |
|
|
| T4248 |
10426-10434 |
Positive_regulation |
denotes |
resulted |
|
|
| T4249 |
10438-10447 |
Gene_expression |
denotes |
secretion |
|
|
| T4250 |
10438-10447 |
Gene_expression |
denotes |
secretion |
|
|
| T4251 |
10451-10454 |
Protein |
denotes |
IL6 |
|
|
| T4252 |
10469-10474 |
Protein |
denotes |
GMCSF |
|
|
| T4253 |
10532-10540 |
Gene_expression |
denotes |
produced |
|
|
| T4254 |
10532-10540 |
Gene_expression |
denotes |
produced |
|
|
| T4255 |
10555-10559 |
Positive_regulation |
denotes |
less |
true |
|
| T4256 |
10555-10559 |
Positive_regulation |
denotes |
less |
true |
|
| T4257 |
10815-10822 |
Protein |
denotes |
Sharpin |
|
|
| T4258 |
10823-10832 |
Negative_regulation |
denotes |
deficient |
|
|
| T4259 |
10870-10877 |
Protein |
denotes |
Sharpin |
|
|
| T4260 |
11091-11098 |
Protein |
denotes |
SHARPIN |
|
|
| T4261 |
11195-11198 |
Protein |
denotes |
Il6 |
|
|
| T4262 |
11200-11207 |
Protein |
denotes |
Il12p40 |
|
|
| T4263 |
11209-11214 |
Protein |
denotes |
Gmcsf |
|
|
| T4264 |
11220-11224 |
Protein |
denotes |
Ifnb |
|
|
| T14222 |
11679-11682 |
Protein |
denotes |
IL6 |
|
|
| T14223 |
11688-11693 |
Protein |
denotes |
GMCSF |
|
|
| T14224 |
11912-11915 |
Protein |
denotes |
IL6 |
|
|
| T14225 |
11981-11988 |
Protein |
denotes |
Sharpin |
|
|
| T14530 |
12685-12695 |
Transcription |
denotes |
expression |
|
true |
| T14531 |
12685-12695 |
Transcription |
denotes |
expression |
|
true |
| T14532 |
12685-12695 |
Transcription |
denotes |
expression |
|
true |
| T14533 |
12685-12695 |
Transcription |
denotes |
expression |
|
true |
| T14534 |
12699-12706 |
Protein |
denotes |
Il12p40 |
|
|
| T14535 |
12714-12717 |
Protein |
denotes |
Il6 |
|
|
| T14536 |
12725-12730 |
Protein |
denotes |
Gmcsf |
|
|
| T14537 |
12742-12746 |
Protein |
denotes |
Ifnb |
|
|
| T5568 |
13365-13369 |
Protein |
denotes |
TLR4 |
|
|
| T5569 |
13394-13398 |
Protein |
denotes |
CD14 |
|
|
| T5570 |
13403-13435 |
Protein |
denotes |
myeloid differentiation factor 2 |
|
|
| T5571 |
13437-13440 |
Protein |
denotes |
MD2 |
|
|
| T5572 |
13441-13445 |
Protein |
denotes |
LY96 |
|
|
| T5573 |
13493-13503 |
Gene_expression |
denotes |
expression |
|
|
| T5574 |
13493-13503 |
Gene_expression |
denotes |
expression |
|
|
| T5575 |
13493-13503 |
Gene_expression |
denotes |
expression |
|
|
| T5576 |
13514-13518 |
Protein |
denotes |
CD14 |
|
|
| T5577 |
13523-13527 |
Protein |
denotes |
TLR4 |
|
|
| T5578 |
13528-13531 |
Protein |
denotes |
MD2 |
|
|
| T5579 |
13604-13613 |
Gene_expression |
denotes |
secretion |
|
true |
| T5580 |
13643-13647 |
Protein |
denotes |
IL10 |
|
|
| T5581 |
13786-13791 |
Positive_regulation |
denotes |
lower |
true |
|
| T5582 |
13792-13798 |
Gene_expression |
denotes |
levels |
|
|
| T5583 |
13802-13806 |
Protein |
denotes |
IL10 |
|
|
| T5584 |
13858-13862 |
Protein |
denotes |
IL10 |
|
|
| T5585 |
13932-13941 |
Positive_regulation |
denotes |
Increased |
|
|
| T5586 |
13942-13952 |
Gene_expression |
denotes |
expression |
|
|
| T5587 |
14002-14005 |
Protein |
denotes |
A20 |
|
|
| T5588 |
14062-14078 |
Transcription |
denotes |
transcript level |
|
|
| T5589 |
14082-14085 |
Protein |
denotes |
A20 |
|
|
| T5590 |
14090-14095 |
Positive_regulation |
denotes |
lower |
true |
|
| T5591 |
14170-14184 |
Positive_regulation |
denotes |
overexpression |
|
|
| T5592 |
14188-14191 |
Protein |
denotes |
A20 |
|
|
| T14938 |
14284-14290 |
Negative_regulation |
denotes |
Normal |
true |
|
| T14939 |
14284-14290 |
Negative_regulation |
denotes |
Normal |
true |
|
| T14940 |
14291-14295 |
Protein |
denotes |
TLR4 |
|
|
| T14941 |
14300-14303 |
Protein |
denotes |
MD2 |
|
|
| T14942 |
14304-14314 |
Gene_expression |
denotes |
expression |
|
|
| T14943 |
14304-14314 |
Gene_expression |
denotes |
expression |
|
|
| T14944 |
14319-14328 |
Negative_regulation |
denotes |
decreased |
|
|
| T14945 |
14319-14328 |
Negative_regulation |
denotes |
decreased |
|
|
| T14946 |
14329-14333 |
Protein |
denotes |
IL10 |
|
|
| T14947 |
14334-14343 |
Gene_expression |
denotes |
secretion |
|
|
| T14948 |
14348-14351 |
Protein |
denotes |
A20 |
|
|
| T14949 |
14352-14362 |
Gene_expression |
denotes |
expression |
|
|
| T14950 |
14764-14768 |
Protein |
denotes |
IL10 |
|
|
| T14951 |
14992-15002 |
Gene_expression |
denotes |
production |
|
true |
| T14952 |
15006-15009 |
Protein |
denotes |
A20 |
|
|
| T5593 |
15035-15039 |
Protein |
denotes |
TLR3 |
|
|
| T5594 |
15040-15041 |
Protein |
denotes |
4 |
|
|
| T5595 |
15154-15158 |
Protein |
denotes |
TBK1 |
|
|
| T5596 |
15159-15163 |
Protein |
denotes |
IRF3 |
|
|
| T5597 |
15224-15228 |
Protein |
denotes |
TBK1 |
|
|
| T5598 |
15229-15233 |
Protein |
denotes |
IRF3 |
|
|
| T5599 |
15319-15326 |
Protein |
denotes |
Sharpin |
|
|
| T5600 |
15327-15336 |
Negative_regulation |
denotes |
deficient |
|
|
| T5601 |
15395-15399 |
Protein |
denotes |
IKK1 |
|
|
| T5602 |
15400-15401 |
Protein |
denotes |
2 |
|
|
| T5603 |
15444-15452 |
Positive_regulation |
denotes |
allowing |
|
|
| T5604 |
15444-15452 |
Positive_regulation |
denotes |
allowing |
|
|
| T5605 |
15453-15468 |
Phosphorylation |
denotes |
phosphorylation |
|
|
| T5606 |
15484-15492 |
Positive_regulation |
denotes |
mediated |
|
|
| T5607 |
15493-15504 |
Protein_catabolism |
denotes |
degradation |
|
|
| T5608 |
15528-15532 |
Protein |
denotes |
IκBα |
|
|
| T5609 |
15608-15622 |
Phosphorylation |
denotes |
phosphorylated |
|
|
| T5610 |
15608-15622 |
Phosphorylation |
denotes |
phosphorylated |
|
|
| T5611 |
15608-15622 |
Phosphorylation |
denotes |
phosphorylated |
|
|
| T5612 |
15623-15627 |
Protein |
denotes |
IKK1 |
|
|
| T5613 |
15628-15629 |
Protein |
denotes |
2 |
|
|
| T5614 |
15633-15637 |
Protein |
denotes |
IKK1 |
|
|
| T5615 |
15638-15639 |
Protein |
denotes |
2 |
|
|
| T5616 |
15645-15649 |
Protein |
denotes |
IκBα |
|
|
| T5617 |
15653-15657 |
Protein |
denotes |
IκBα |
|
|
| T5618 |
15714-15723 |
Negative_regulation |
denotes |
decreased |
|
|
| T5619 |
15714-15723 |
Negative_regulation |
denotes |
decreased |
|
|
| T5620 |
15714-15723 |
Negative_regulation |
denotes |
decreased |
|
|
| T5621 |
15818-15822 |
Protein |
denotes |
TBK1 |
|
|
| T5622 |
15824-15828 |
Protein |
denotes |
ERK1 |
|
|
| T5623 |
15829-15830 |
Protein |
denotes |
2 |
|
|
| T5624 |
15840-15855 |
Phosphorylation |
denotes |
phosphorylation |
|
|
| T5625 |
15840-15855 |
Phosphorylation |
denotes |
phosphorylation |
|
|
| T5626 |
15840-15855 |
Phosphorylation |
denotes |
phosphorylation |
|
|
| T5627 |
15919-15926 |
Negative_regulation |
denotes |
absence |
|
|
| T5628 |
15941-15948 |
Protein |
denotes |
SHARPIN |
|
|
| T5629 |
15995-15999 |
Protein |
denotes |
TBK1 |
|
|
| T5630 |
16000-16004 |
Protein |
denotes |
IRF3 |
|
|
| T5631 |
16006-16010 |
Protein |
denotes |
ERK1 |
|
|
| T5632 |
16011-16012 |
Protein |
denotes |
2 |
|
|
| T15295 |
16393-16397 |
Protein |
denotes |
TBK1 |
|
|
| T15296 |
16398-16402 |
Protein |
denotes |
IRF3 |
|
|
| T15297 |
16404-16408 |
Protein |
denotes |
ERK1 |
|
|
| T15298 |
16409-16410 |
Protein |
denotes |
2 |
|
|
| T15299 |
16440-16450 |
Protein |
denotes |
Beta-actin |
|
|
| T15300 |
16505-16509 |
Protein |
denotes |
IKK1 |
|
|
| T15301 |
16510-16511 |
Protein |
denotes |
2 |
|
|
| T15302 |
16518-16522 |
Protein |
denotes |
IκBα |
|
|
| T6522 |
16851-16858 |
Negative_regulation |
denotes |
absence |
|
|
| T6523 |
16862-16869 |
Protein |
denotes |
SHARPIN |
|
|
| T6524 |
17046-17054 |
Positive_regulation |
denotes |
elicited |
|
|
| T6525 |
17062-17066 |
Protein |
denotes |
IFNγ |
|
|
| T6526 |
17067-17077 |
Gene_expression |
denotes |
production |
|
|
| T6527 |
17091-17104 |
Gene_expression |
denotes |
concentration |
|
|
| T6528 |
17108-17112 |
Protein |
denotes |
IFNγ |
|
|
| T6529 |
17160-17165 |
Positive_regulation |
denotes |
lower |
true |
|
| T6530 |
17273-17277 |
Protein |
denotes |
TLR3 |
|
|
| T6531 |
17278-17279 |
Protein |
denotes |
4 |
|
|
| T6532 |
17280-17288 |
Positive_regulation |
denotes |
agonists |
|
|
| T6533 |
17280-17288 |
Positive_regulation |
denotes |
agonists |
|
|
| T6534 |
17294-17298 |
Protein |
denotes |
TLR2 |
|
|
| T6535 |
17299-17305 |
Binding |
denotes |
ligand |
|
|
| T6536 |
17306-17313 |
Protein |
denotes |
Pam3CYS |
|
|
| T6537 |
17395-17402 |
Protein |
denotes |
Pam3CYS |
|
|
| T6538 |
17419-17426 |
Positive_regulation |
denotes |
induced |
|
|
| T6539 |
17434-17438 |
Protein |
denotes |
IFNγ |
|
|
| T6540 |
17439-17449 |
Gene_expression |
denotes |
production |
|
|
| T6541 |
17550-17557 |
Protein |
denotes |
Pam3CYS |
|
|
| T6542 |
17666-17670 |
Protein |
denotes |
TLR2 |
|
|
| T6543 |
17720-17723 |
Protein |
denotes |
IL4 |
|
|
| T6544 |
17737-17745 |
Gene_expression |
denotes |
produced |
|
|
| T6545 |
17861-17871 |
Gene_expression |
denotes |
production |
|
|
| T6546 |
17898-17903 |
Protein |
denotes |
IL17A |
|
|
| T6547 |
17904-17913 |
Positive_regulation |
denotes |
following |
|
|
| T6548 |
18134-18137 |
Protein |
denotes |
IL2 |
|
|
| T6549 |
18138-18148 |
Gene_expression |
denotes |
production |
|
|
| T6550 |
18224-18231 |
Positive_regulation |
denotes |
induced |
|
|
| T6551 |
18232-18236 |
Positive_regulation |
denotes |
more |
|
|
| T6552 |
18237-18240 |
Protein |
denotes |
IL2 |
|
|
| T15724 |
18959-18968 |
Gene_expression |
denotes |
secretion |
|
true |
| T15725 |
18959-18968 |
Gene_expression |
denotes |
secretion |
|
true |
| T15726 |
18959-18968 |
Gene_expression |
denotes |
secretion |
|
true |
| T15727 |
18972-18976 |
Protein |
denotes |
IFNγ |
|
|
| T15728 |
18978-18981 |
Protein |
denotes |
IL4 |
|
|
| T15729 |
18987-18990 |
Protein |
denotes |
IL2 |
|
|
| T15730 |
19227-19237 |
Gene_expression |
denotes |
production |
true |
|
| T15731 |
19227-19237 |
Gene_expression |
denotes |
production |
true |
|
| T15732 |
19227-19237 |
Gene_expression |
denotes |
production |
true |
|
| T9371 |
19386-19400 |
Negative_regulation |
denotes |
null mutations |
|
|
| T9372 |
19414-19421 |
Protein |
denotes |
Sharpin |
|
|
| T9373 |
19546-19550 |
Negative_regulation |
denotes |
loss |
|
|
| T9374 |
19554-19561 |
Protein |
denotes |
SHARPIN |
|
|
| T9375 |
20029-20036 |
Protein |
denotes |
SHARPIN |
|
|
| T9376 |
20079-20089 |
Negative_regulation |
denotes |
disruption |
|
|
| T9377 |
20750-20754 |
Protein |
denotes |
TNFα |
|
|
| T9378 |
20825-20833 |
Negative_regulation |
denotes |
deletion |
|
|
| T9379 |
20837-20840 |
Protein |
denotes |
TNF |
|
|
| T9380 |
20867-20877 |
Negative_regulation |
denotes |
deficiency |
|
|
| T9381 |
20881-20888 |
Protein |
denotes |
SHARPIN |
|
|
| T9382 |
21359-21364 |
Protein |
denotes |
HMGB1 |
|
|
| T9383 |
21365-21375 |
Binding |
denotes |
recognized |
|
|
| T9384 |
21379-21383 |
Protein |
denotes |
TLR2 |
|
|
| T9385 |
21384-21385 |
Protein |
denotes |
4 |
|
|
| T9386 |
21892-21899 |
Protein |
denotes |
IL12P35 |
|
|
| T9387 |
21905-21912 |
Protein |
denotes |
IL12P40 |
|
|
| T9388 |
21913-21922 |
Negative_regulation |
denotes |
deficient |
|
|
| T9389 |
21913-21922 |
Negative_regulation |
denotes |
deficient |
|
|
| T9390 |
22008-22012 |
Protein |
denotes |
IRF3 |
|
|
| T9391 |
22274-22284 |
Positive_regulation |
denotes |
activation |
|
|
| T9392 |
22274-22284 |
Positive_regulation |
denotes |
activation |
|
|
| T9393 |
22274-22284 |
Positive_regulation |
denotes |
activation |
|
|
| T9394 |
22274-22284 |
Positive_regulation |
denotes |
activation |
|
|
| T9395 |
22288-22292 |
Protein |
denotes |
TBK1 |
|
|
| T9396 |
22293-22297 |
Protein |
denotes |
IRF3 |
|
|
| T9397 |
22299-22303 |
Protein |
denotes |
ERK1 |
|
|
| T9398 |
22304-22305 |
Protein |
denotes |
2 |
|
|
| T9399 |
22314-22321 |
Negative_regulation |
denotes |
was not |
true |
|
| T9400 |
22314-22321 |
Negative_regulation |
denotes |
was not |
true |
|
| T9401 |
22314-22321 |
Negative_regulation |
denotes |
was not |
true |
|
| T9402 |
22314-22321 |
Negative_regulation |
denotes |
was not |
true |
|
| T9403 |
22730-22737 |
Protein |
denotes |
SHARPIN |
|
|
| T9404 |
22892-22895 |
Protein |
denotes |
A20 |
|
|
| T9405 |
22900-22904 |
Protein |
denotes |
ITCH |
|
|
| T9406 |
23495-23503 |
Negative_regulation |
denotes |
deletion |
|
|
| T9407 |
23507-23514 |
Protein |
denotes |
Sharpin |
|
|
| T9408 |
23572-23579 |
Protein |
denotes |
SHARPIN |
|
|
| T9409 |
23639-23646 |
Negative_regulation |
denotes |
absence |
|
|
| T9410 |
23650-23657 |
Protein |
denotes |
Sharpin |
|
|
| T9411 |
23658-23668 |
Gene_expression |
denotes |
expression |
|
|
| T9412 |
24010-24014 |
Protein |
denotes |
p100 |
|
|
| T9413 |
24037-24040 |
Protein |
denotes |
p52 |
|
|
| T9414 |
24066-24073 |
Protein |
denotes |
SHARPIN |
|
|
| T9415 |
24074-24083 |
Negative_regulation |
denotes |
deficient |
|
|
| T9416 |
24137-24140 |
Protein |
denotes |
p52 |
|
|
| T9417 |
24141-24145 |
Protein |
denotes |
RELB |
|
|
| T9418 |
24261-24268 |
Protein |
denotes |
Sharpin |
|
|
| T9419 |
24269-24277 |
Negative_regulation |
denotes |
mutation |
|
|
| T9420 |
24414-24420 |
Binding |
denotes |
engage |
|
|
| T9421 |
24414-24420 |
Binding |
denotes |
engage |
|
|
| T9422 |
24421-24425 |
Protein |
denotes |
TLR4 |
|
|
| T9423 |
24430-24434 |
Protein |
denotes |
TLR3 |
|
|
| T9424 |
24646-24653 |
Binding |
denotes |
engages |
|
|
| T9425 |
24654-24658 |
Protein |
denotes |
TLR4 |
|
|
| T9426 |
24671-24676 |
Protein |
denotes |
MYD88 |
|
|
| T9427 |
24691-24695 |
Protein |
denotes |
TRIF |
|
|
| T9428 |
24724-24728 |
Protein |
denotes |
TLR3 |
|
|
| T9429 |
24729-24739 |
Positive_regulation |
denotes |
stimulated |
|
|
| T9430 |
24766-24770 |
Protein |
denotes |
TRIF |
|
|
| T9431 |
24862-24869 |
Protein |
denotes |
Sharpin |
|
|
| T9432 |
24870-24878 |
Negative_regulation |
denotes |
mutation |
|
|
| T9433 |
24970-24974 |
Protein |
denotes |
RIP1 |
|
|
| T9434 |
24979-24984 |
Protein |
denotes |
TRAF6 |
|
|
| T9435 |
25024-25031 |
Protein |
denotes |
SHARPIN |
|
|
| T9436 |
25032-25041 |
Binding |
denotes |
interacts |
|
|
| T9437 |
25047-25051 |
Protein |
denotes |
HOIP |
|
|
| T9438 |
25071-25077 |
Positive_regulation |
denotes |
exerts |
|
|
| T9439 |
25071-25077 |
Positive_regulation |
denotes |
exerts |
|
|
| T9440 |
25082-25120 |
Ubiquitination |
denotes |
linear-ubiquitin-chain-ligase activity |
|
|
| T9441 |
25082-25120 |
Ubiquitination |
denotes |
linear-ubiquitin-chain-ligase activity |
|
|
| T9442 |
25148-25152 |
Protein |
denotes |
RIP1 |
|
|
| T9443 |
25157-25161 |
Protein |
denotes |
NEMO |
|
|
| T9444 |
25196-25200 |
Protein |
denotes |
TNFα |
|
|
| T9445 |
25234-25241 |
Protein |
denotes |
Sharpin |
|
|
| T9446 |
25242-25255 |
Negative_regulation |
denotes |
null mutation |
|
|
| T9447 |
25256-25264 |
Negative_regulation |
denotes |
disrupts |
|
|
| T9448 |
25256-25264 |
Negative_regulation |
denotes |
disrupts |
|
|
| T9449 |
25310-25314 |
Protein |
denotes |
TNFα |
|
|
| T9450 |
25478-25485 |
Protein |
denotes |
SHARPIN |
|
|
| T9451 |
25599-25606 |
Protein |
denotes |
SHARPIN |
|
|
| T9452 |
25728-25735 |
Protein |
denotes |
Sharpin |
|
|
| T9453 |
25736-25745 |
Negative_regulation |
denotes |
deficient |
|
|
| T9936 |
26835-26842 |
Protein |
denotes |
Sharpin |
|
|
| T10316 |
27233-27240 |
Protein |
denotes |
Sharpin |
|
|
| T10317 |
27433-27440 |
Protein |
denotes |
Sharpin |
|
|
| T10318 |
27546-27553 |
Gene_expression |
denotes |
express |
|
|
| T10319 |
27566-27573 |
Protein |
denotes |
SHARPIN |
|
|
| T10320 |
27705-27712 |
Protein |
denotes |
SHARPIN |
|
|
| T10321 |
27896-27903 |
Protein |
denotes |
SHARPIN |
|
|
| T10322 |
27904-27914 |
Gene_expression |
denotes |
expression |
|
true |
| T11284 |
29926-29935 |
Gene_expression |
denotes |
secretion |
|
true |
| T11285 |
29926-29935 |
Gene_expression |
denotes |
secretion |
|
true |
| T11286 |
29926-29935 |
Gene_expression |
denotes |
secretion |
|
true |
| T11287 |
29926-29935 |
Gene_expression |
denotes |
secretion |
|
true |
| T11288 |
29939-29943 |
Protein |
denotes |
IFNγ |
|
|
| T11289 |
29945-29948 |
Protein |
denotes |
IL4 |
|
|
| T11290 |
29950-29953 |
Protein |
denotes |
IL2 |
|
|
| T11291 |
29959-29964 |
Protein |
denotes |
IL17A |
|
|
| T11292 |
30173-30183 |
Gene_expression |
denotes |
production |
true |
|
| T11293 |
30173-30183 |
Gene_expression |
denotes |
production |
true |
|
| T11294 |
30173-30183 |
Gene_expression |
denotes |
production |
true |
|
| T11295 |
30173-30183 |
Gene_expression |
denotes |
production |
true |
|
| T11890 |
30489-30499 |
Transcription |
denotes |
expression |
|
true |
| T11891 |
30489-30499 |
Transcription |
denotes |
expression |
|
true |
| T11892 |
30489-30499 |
Transcription |
denotes |
expression |
|
true |
| T11893 |
30489-30499 |
Transcription |
denotes |
expression |
|
true |
| T11894 |
30503-30506 |
Protein |
denotes |
Il6 |
|
|
| T11895 |
30508-30515 |
Protein |
denotes |
Il12p40 |
|
|
| T11896 |
30517-30522 |
Protein |
denotes |
Gmcsf |
|
|
| T11897 |
30528-30535 |
Protein |
denotes |
Sharpin |
|
|
| T11898 |
30856-30883 |
Protein |
denotes |
M-MLV Reverse Transcriptase |
|
|
| T11899 |
31218-31222 |
Protein |
denotes |
Actb |
|
|
| T11900 |
31224-31227 |
Protein |
denotes |
IL6 |
|
|
| T11901 |
31229-31236 |
Protein |
denotes |
IL12p40 |
|
|
| T11902 |
31238-31242 |
Protein |
denotes |
Ifnβ |
|
|
| T11903 |
31244-31249 |
Protein |
denotes |
Gmcsf |
|
|
| T11904 |
31255-31262 |
Protein |
denotes |
Sharpin |
|
|
| T11905 |
31370-31377 |
Protein |
denotes |
β-actin |
|
|
| T12351 |
31933-31940 |
Protein |
denotes |
SHARPIN |
|
|
| T12662 |
32776-32780 |
Protein |
denotes |
IKK1 |
|
|
| T12663 |
32781-32782 |
Protein |
denotes |
2 |
|
|
| T12664 |
32793-32797 |
Protein |
denotes |
IκBα |
|
|
| T12665 |
32807-32811 |
Protein |
denotes |
IκBα |
|
|
| T12666 |
32823-32827 |
Protein |
denotes |
TBK1 |
|
|
| T12667 |
32866-32870 |
Protein |
denotes |
ERK1 |
|
|
| T12668 |
32871-32872 |
Protein |
denotes |
2 |
|
|
| T12669 |
32886-32890 |
Protein |
denotes |
ERK1 |
|
|
| T12670 |
32891-32892 |
Protein |
denotes |
2 |
|
|
| T12671 |
32902-32912 |
Protein |
denotes |
Beta-actin |
|
|
| R11000 |
T13241 |
T13240 |
themeOf |
Sharpin,mRNA level |
| R11001 |
T13243 |
T13245 |
themeOf |
SHARPIN,localized |
| R11002 |
T13244 |
T13245 |
locationOf |
cytoplasm,localized |
| R11497 |
T13792 |
T13793 |
themeOf |
Sharpin,mutation |
| R12159 |
T14534 |
T14533 |
themeOf |
Il12p40,expression |
| R12160 |
T14535 |
T14532 |
themeOf |
Il6,expression |
| R12161 |
T14536 |
T14531 |
themeOf |
Gmcsf,expression |
| R12162 |
T14537 |
T14530 |
themeOf |
Ifnb,expression |
| R12521 |
T14940 |
T14943 |
themeOf |
TLR4,expression |
| R12522 |
T14941 |
T14942 |
themeOf |
MD2,expression |
| R12523 |
T14942 |
T14939 |
themeOf |
expression,Normal |
| R12524 |
T14943 |
T14938 |
themeOf |
expression,Normal |
| R12525 |
T14946 |
T14947 |
themeOf |
IL10,secretion |
| R12526 |
T14947 |
T14944 |
themeOf |
secretion,decreased |
| R12527 |
T14948 |
T14949 |
themeOf |
A20,expression |
| R12528 |
T14949 |
T14945 |
themeOf |
expression,decreased |
| R12529 |
T14952 |
T14951 |
themeOf |
A20,production |
| R13160 |
T15727 |
T15726 |
themeOf |
IFNγ,secretion |
| R13161 |
T15727 |
T15730 |
themeOf |
IFNγ,production |
| R13162 |
T15728 |
T15724 |
themeOf |
IL4,secretion |
| R13163 |
T15728 |
T15731 |
themeOf |
IL4,production |
| R13164 |
T15729 |
T15732 |
themeOf |
IL2,production |
| R13165 |
T15729 |
T15725 |
themeOf |
IL2,secretion |
| R1757 |
T2107 |
T2108 |
themeOf |
SHARPIN,expressed |
| R1758 |
T2109 |
T2112 |
causeOf |
recessive mutations,resulting |
| R1761 |
T2109 |
T2111 |
causeOf |
recessive mutations,resulting |
| R1762 |
T2110 |
T2115 |
themeOf |
Sharpin,absence |
| R1763 |
T2110 |
T2114 |
themeOf |
Sharpin,synthesis |
| R1764 |
T2110 |
T2109 |
themeOf |
Sharpin,recessive mutations |
| R1765 |
T2113 |
T2111 |
themeOf |
termination,resulting |
| R1766 |
T2114 |
T2113 |
themeOf |
synthesis,termination |
| R1767 |
T2115 |
T2112 |
themeOf |
absence,resulting |
| R1768 |
T2120 |
T2119 |
themeOf |
IL5,Neutralization |
| R1769 |
T2117 |
T2116 |
themeOf |
secretion,decreased |
| R1770 |
T2121 |
T2122 |
themeOf |
IL5,deficient |
| R1771 |
T2118 |
T2117 |
themeOf |
IFNγ,secretion |
| R1772 |
T2125 |
T2126 |
themeOf |
SHARPIN,deficient |
| R1774 |
T2128 |
T2129 |
themeOf |
SHARPIN,deficient |
| R1775 |
T2131 |
T2130 |
themeOf |
SHARPIN,lack |
| R1777 |
T2133 |
T2134 |
themeOf |
SHARPIN,deficient |
| R2277 |
T2759 |
T2758 |
themeOf |
Sharpin,mutations |
| R2278 |
T2761 |
T2760 |
themeOf |
Sharpin,expression |
| R2279 |
T2762 |
T2763 |
themeOf |
Sharpin,present |
| R2280 |
T2763 |
T2764 |
themeOf |
present,decreased |
| R2281 |
T2766 |
T2765 |
themeOf |
Sharpin,reduction |
| R2282 |
T2768 |
T2769 |
locationOf |
cytoplasmic,localization |
| R2283 |
T2770 |
T2769 |
themeOf |
SHARPIN,localization |
| R3092 |
T3733 |
T3734 |
themeOf |
Sharpin,mutation |
| R3093 |
T3741 |
T3742 |
themeOf |
SHARPIN,deficiency |
| R3094 |
T3743 |
T3744 |
themeOf |
Sharpin,mutation |
| R3095 |
T3749 |
T3750 |
themeOf |
TLR3,ligand |
| R3096 |
T3751 |
T3752 |
themeOf |
TLR4,ligand |
| R3097 |
T3756 |
T3753 |
themeOf |
increased,resulted |
| R3098 |
T3757 |
T3754 |
themeOf |
increased,resulted |
| R3099 |
T3758 |
T3755 |
themeOf |
increased,resulted |
| R3100 |
T3759 |
T3757 |
themeOf |
expression,increased |
| R3101 |
T3760 |
T3758 |
themeOf |
expression,increased |
| R3102 |
T3761 |
T3756 |
themeOf |
expression,increased |
| R3103 |
T3762 |
T3759 |
themeOf |
CD40,expression |
| R3104 |
T3762 |
T3768 |
themeOf |
CD40,expression |
| R3105 |
T3763 |
T3760 |
themeOf |
CD80,expression |
| R3106 |
T3763 |
T3769 |
themeOf |
CD80,expression |
| R3107 |
T3764 |
T3761 |
themeOf |
CD86,expression |
| R3108 |
T3764 |
T3770 |
themeOf |
CD86,expression |
| R3109 |
T3768 |
T3765 |
themeOf |
expression,difference |
| R3110 |
T3769 |
T3766 |
themeOf |
expression,difference |
| R3111 |
T3770 |
T3767 |
themeOf |
expression,difference |
| R3112 |
T3771 |
T3772 |
themeOf |
SHARPIN,deficiency |
| R3521 |
T4249 |
T4248 |
themeOf |
secretion,resulted |
| R3522 |
T4250 |
T4247 |
themeOf |
secretion,resulted |
| R3523 |
T4251 |
T4250 |
themeOf |
IL6,secretion |
| R3524 |
T4251 |
T4253 |
themeOf |
IL6,produced |
| R3525 |
T4252 |
T4249 |
themeOf |
GMCSF,secretion |
| R3526 |
T4252 |
T4254 |
themeOf |
GMCSF,produced |
| R3527 |
T4253 |
T4255 |
themeOf |
produced,less |
| R3528 |
T4254 |
T4256 |
themeOf |
produced,less |
| R3529 |
T4257 |
T4258 |
themeOf |
Sharpin,deficient |
| R4513 |
T5571 |
T5570 |
equivalentTo |
MD2,myeloid differentiation factor 2 |
| R4514 |
T5572 |
T5570 |
equivalentTo |
LY96,myeloid differentiation factor 2 |
| R4515 |
T5576 |
T5574 |
themeOf |
CD14,expression |
| R4516 |
T5577 |
T5575 |
themeOf |
TLR4,expression |
| R4517 |
T5578 |
T5573 |
themeOf |
MD2,expression |
| R4518 |
T5580 |
T5579 |
themeOf |
IL10,secretion |
| R4519 |
T5582 |
T5581 |
themeOf |
levels,lower |
| R4520 |
T5583 |
T5582 |
themeOf |
IL10,levels |
| R4521 |
T5586 |
T5585 |
themeOf |
expression,Increased |
| R4522 |
T5587 |
T5586 |
themeOf |
A20,expression |
| R4523 |
T5588 |
T5590 |
themeOf |
transcript level,lower |
| R4524 |
T5589 |
T5588 |
themeOf |
A20,transcript level |
| R4525 |
T5592 |
T5591 |
themeOf |
A20,overexpression |
| R4526 |
T5599 |
T5600 |
themeOf |
Sharpin,deficient |
| R4527 |
T5605 |
T5604 |
themeOf |
phosphorylation,allowing |
| R4528 |
T5607 |
T5603 |
themeOf |
degradation,allowing |
| R4529 |
T5607 |
T5606 |
themeOf |
degradation,mediated |
| R4530 |
T5608 |
T5605 |
themeOf |
IκBα,phosphorylation |
| R4531 |
T5608 |
T5607 |
themeOf |
IκBα,degradation |
| R4532 |
T5609 |
T5618 |
themeOf |
phosphorylated,decreased |
| R4533 |
T5610 |
T5620 |
themeOf |
phosphorylated,decreased |
| R4534 |
T5611 |
T5619 |
themeOf |
phosphorylated,decreased |
| R4535 |
T5612 |
T5610 |
themeOf |
IKK1,phosphorylated |
| R4536 |
T5613 |
T5609 |
themeOf |
2,phosphorylated |
| R4537 |
T5616 |
T5611 |
themeOf |
IκBα,phosphorylated |
| R4538 |
T5621 |
T5626 |
themeOf |
TBK1,phosphorylation |
| R4539 |
T5622 |
T5624 |
themeOf |
ERK1,phosphorylation |
| R4540 |
T5623 |
T5625 |
themeOf |
2,phosphorylation |
| R4541 |
T5628 |
T5627 |
themeOf |
SHARPIN,absence |
| R5295 |
T6523 |
T6522 |
themeOf |
SHARPIN,absence |
| R5296 |
T6525 |
T6526 |
themeOf |
IFNγ,production |
| R5297 |
T6526 |
T6524 |
themeOf |
production,elicited |
| R5298 |
T6527 |
T6529 |
themeOf |
concentration,lower |
| R5299 |
T6528 |
T6527 |
themeOf |
IFNγ,concentration |
| R5300 |
T6530 |
T6533 |
themeOf |
TLR3,agonists |
| R5301 |
T6531 |
T6532 |
themeOf |
4,agonists |
| R5302 |
T6534 |
T6535 |
themeOf |
TLR2,ligand |
| R5303 |
T6536 |
T6535 |
themeOf |
Pam3CYS,ligand |
| R5304 |
T6537 |
T6538 |
causeOf |
Pam3CYS,induced |
| R5305 |
T6539 |
T6540 |
themeOf |
IFNγ,production |
| R5306 |
T6540 |
T6538 |
themeOf |
production,induced |
| R5307 |
T6543 |
T6544 |
themeOf |
IL4,produced |
| R5308 |
T6545 |
T6547 |
themeOf |
production,following |
| R5309 |
T6546 |
T6545 |
themeOf |
IL17A,production |
| R5310 |
T6548 |
T6549 |
themeOf |
IL2,production |
| R5311 |
T6550 |
T6551 |
themeOf |
induced,more |
| R5312 |
T6552 |
T6550 |
themeOf |
IL2,induced |
| R629 |
T837 |
T836 |
themeOf |
Sharpin,loss |
| R694 |
T804 |
T803 |
themeOf |
Sharpin,mutations |
| R695 |
T805 |
T804 |
equivalentTo |
SHANK-associated RH domain-interacting protein,Sharpin |
| R696 |
T806 |
T804 |
equivalentTo |
Rbckl1,Sharpin |
| R697 |
T807 |
T804 |
equivalentTo |
Sipl1,Sharpin |
| R698 |
T808 |
T809 |
themeOf |
SHARPIN,deficient |
| R699 |
T810 |
T811 |
themeOf |
SHARPIN,deficiency |
| R700 |
T815 |
T816 |
themeOf |
SHARPIN,deficient |
| R701 |
T816 |
T818 |
causeOf |
deficient,reduced |
| R702 |
T816 |
T820 |
causeOf |
deficient,reduced |
| R703 |
T816 |
T819 |
causeOf |
deficient,reduced |
| R704 |
T816 |
T817 |
causeOf |
deficient,reduced |
| R705 |
T821 |
T818 |
themeOf |
transcription,reduced |
| R706 |
T822 |
T820 |
themeOf |
transcription,reduced |
| R707 |
T823 |
T817 |
themeOf |
secretion,reduced |
| R708 |
T824 |
T819 |
themeOf |
secretion,reduced |
| R709 |
T825 |
T821 |
themeOf |
IL6,transcription |
| R710 |
T825 |
T824 |
themeOf |
IL6,secretion |
| R711 |
T826 |
T822 |
themeOf |
GMCSF,transcription |
| R712 |
T826 |
T823 |
themeOf |
GMCSF,secretion |
| R713 |
T829 |
T827 |
equivalentTo |
ERK1,MAPK1 |
| R714 |
T830 |
T828 |
equivalentTo |
2,3 |
| R7734 |
T9372 |
T9371 |
themeOf |
Sharpin,null mutations |
| R7735 |
T9374 |
T9373 |
themeOf |
SHARPIN,loss |
| R7736 |
T9375 |
T9376 |
themeOf |
SHARPIN,disruption |
| R7739 |
T9379 |
T9378 |
themeOf |
TNF,deletion |
| R7740 |
T9381 |
T9380 |
themeOf |
SHARPIN,deficiency |
| R7741 |
T9382 |
T9383 |
themeOf |
HMGB1,recognized |
| R7743 |
T9384 |
T9383 |
themeOf |
TLR2,recognized |
| R7744 |
T9386 |
T9389 |
themeOf |
IL12P35,deficient |
| R7745 |
T9387 |
T9388 |
themeOf |
IL12P40,deficient |
| R7747 |
T9391 |
T9400 |
themeOf |
activation,was not |
| R7748 |
T9392 |
T9402 |
themeOf |
activation,was not |
| R7749 |
T9393 |
T9399 |
themeOf |
activation,was not |
| R7750 |
T9394 |
T9401 |
themeOf |
activation,was not |
| R7751 |
T9395 |
T9394 |
themeOf |
TBK1,activation |
| R7753 |
T9396 |
T9393 |
themeOf |
IRF3,activation |
| R7754 |
T9397 |
T9391 |
themeOf |
ERK1,activation |
| R7755 |
T9398 |
T9392 |
themeOf |
2,activation |
| R7759 |
T9407 |
T9406 |
themeOf |
Sharpin,deletion |
| R7761 |
T9410 |
T9411 |
themeOf |
Sharpin,expression |
| R7762 |
T9411 |
T9409 |
themeOf |
expression,absence |
| R7764 |
T9414 |
T9415 |
themeOf |
SHARPIN,deficient |
| R7767 |
T9418 |
T9419 |
themeOf |
Sharpin,mutation |
| R7769 |
T9422 |
T9420 |
themeOf |
TLR4,engage |
| R7770 |
T9423 |
T9421 |
themeOf |
TLR3,engage |
| R7772 |
T9425 |
T9424 |
themeOf |
TLR4,engages |
| R7775 |
T9428 |
T9429 |
themeOf |
TLR3,stimulated |
| R7777 |
T9431 |
T9432 |
themeOf |
Sharpin,mutation |
| R7780 |
T9435 |
T9436 |
themeOf |
SHARPIN,interacts |
| R7781 |
T9435 |
T9440 |
causeOf |
SHARPIN,linear-ubiquitin-chain-ligase activity |
| R7782 |
T9435 |
T9441 |
causeOf |
SHARPIN,linear-ubiquitin-chain-ligase activity |
| R7783 |
T9437 |
T9436 |
themeOf |
HOIP,interacts |
| R7785 |
T9440 |
T9439 |
themeOf |
linear-ubiquitin-chain-ligase activity,exerts |
| R7786 |
T9440 |
T9447 |
themeOf |
linear-ubiquitin-chain-ligase activity,disrupts |
| R7788 |
T9441 |
T9438 |
themeOf |
linear-ubiquitin-chain-ligase activity,exerts |
| R7789 |
T9441 |
T9448 |
themeOf |
linear-ubiquitin-chain-ligase activity,disrupts |
| R7791 |
T9442 |
T9440 |
themeOf |
RIP1,linear-ubiquitin-chain-ligase activity |
| R7792 |
T9443 |
T9441 |
themeOf |
NEMO,linear-ubiquitin-chain-ligase activity |
| R7793 |
T9445 |
T9446 |
themeOf |
Sharpin,null mutation |
| R7794 |
T9446 |
T9447 |
causeOf |
null mutation,disrupts |
| R7795 |
T9446 |
T9448 |
causeOf |
null mutation,disrupts |
| R7797 |
T9452 |
T9453 |
themeOf |
Sharpin,deficient |
| R8505 |
T10319 |
T10318 |
themeOf |
SHARPIN,express |
| R8506 |
T10321 |
T10322 |
themeOf |
SHARPIN,expression |
| R9372 |
T11288 |
T11292 |
themeOf |
IFNγ,production |
| R9373 |
T11288 |
T11287 |
themeOf |
IFNγ,secretion |
| R9374 |
T11289 |
T11293 |
themeOf |
IL4,production |
| R9375 |
T11289 |
T11286 |
themeOf |
IL4,secretion |
| R9376 |
T11290 |
T11294 |
themeOf |
IL2,production |
| R9377 |
T11290 |
T11284 |
themeOf |
IL2,secretion |
| R9378 |
T11291 |
T11295 |
themeOf |
IL17A,production |
| R9379 |
T11291 |
T11285 |
themeOf |
IL17A,secretion |
| R9877 |
T11894 |
T11893 |
themeOf |
Il6,expression |
| R9878 |
T11895 |
T11892 |
themeOf |
Il12p40,expression |
| R9879 |
T11896 |
T11891 |
themeOf |
Gmcsf,expression |
| R9880 |
T11897 |
T11890 |
themeOf |
Sharpin,expression |
