Id |
Subject |
Object |
Predicate |
Lexical cue |
T2996 |
0-4 |
IN |
denotes |
From |
T2998 |
5-9 |
NN |
denotes |
E9.5 |
T2999 |
10-12 |
IN |
denotes |
to |
T3000 |
13-18 |
NN |
denotes |
E12.5 |
T3001 |
18-20 |
, |
denotes |
, |
T3002 |
20-25 |
NN |
denotes |
Ptdsr |
T3004 |
26-27 |
SYM |
denotes |
- |
T3005 |
27-28 |
HYPH |
denotes |
/ |
T3006 |
28-29 |
SYM |
denotes |
- |
T3003 |
31-38 |
NNS |
denotes |
embryos |
T2997 |
39-43 |
VBD |
denotes |
were |
T3007 |
44-50 |
JJ |
denotes |
viable |
T3008 |
51-54 |
CC |
denotes |
and |
T3009 |
55-57 |
IN |
denotes |
of |
T3010 |
58-64 |
JJ |
denotes |
normal |
T3011 |
65-69 |
NN |
denotes |
size |
T3012 |
69-70 |
. |
denotes |
. |
T3013 |
70-172 |
sentence |
denotes |
At E13.5 and thereafter, however, most Ptdsr -/-embryos showed morphological abnormalities (Table 1). |
T3014 |
71-73 |
IN |
denotes |
At |
T3016 |
74-79 |
NN |
denotes |
E13.5 |
T3017 |
80-83 |
CC |
denotes |
and |
T3018 |
84-94 |
RB |
denotes |
thereafter |
T3019 |
94-96 |
, |
denotes |
, |
T3020 |
96-103 |
RB |
denotes |
however |
T3021 |
103-105 |
, |
denotes |
, |
T3022 |
105-109 |
JJS |
denotes |
most |
T3024 |
110-115 |
NN |
denotes |
Ptdsr |
T3025 |
116-117 |
SYM |
denotes |
- |
T3026 |
117-118 |
HYPH |
denotes |
/ |
T3027 |
118-119 |
SYM |
denotes |
- |
T3023 |
119-126 |
NNS |
denotes |
embryos |
T3015 |
127-133 |
VBD |
denotes |
showed |
T3028 |
134-147 |
JJ |
denotes |
morphological |
T3029 |
148-161 |
NNS |
denotes |
abnormalities |
T3030 |
162-163 |
-LRB- |
denotes |
( |
T3031 |
163-168 |
NN |
denotes |
Table |
T3032 |
169-170 |
CD |
denotes |
1 |
T3033 |
170-171 |
-RRB- |
denotes |
) |
T3034 |
171-172 |
. |
denotes |
. |
T3035 |
172-323 |
sentence |
denotes |
All homozygous embryos harvested were growth-retarded from E13.5 onwards, had a pale appearance, and displayed multiple developmental dysmorphologies. |
T3036 |
173-176 |
DT |
denotes |
All |
T3038 |
177-187 |
JJ |
denotes |
homozygous |
T3037 |
188-195 |
NNS |
denotes |
embryos |
T3040 |
196-205 |
VBN |
denotes |
harvested |
T3039 |
206-210 |
VBD |
denotes |
were |
T3041 |
211-217 |
NN |
denotes |
growth |
T3043 |
217-218 |
HYPH |
denotes |
- |
T3042 |
218-226 |
VBN |
denotes |
retarded |
T3044 |
227-231 |
IN |
denotes |
from |
T3045 |
232-237 |
NN |
denotes |
E13.5 |
T3046 |
238-245 |
RB |
denotes |
onwards |
T3047 |
245-247 |
, |
denotes |
, |
T3048 |
247-250 |
VBD |
denotes |
had |
T3049 |
251-252 |
DT |
denotes |
a |
T3051 |
253-257 |
JJ |
denotes |
pale |
T3050 |
258-268 |
NN |
denotes |
appearance |
T3052 |
268-270 |
, |
denotes |
, |
T3053 |
270-273 |
CC |
denotes |
and |
T3054 |
274-283 |
VBD |
denotes |
displayed |
T3055 |
284-292 |
JJ |
denotes |
multiple |
T3057 |
293-306 |
JJ |
denotes |
developmental |
T3056 |
307-322 |
NNS |
denotes |
dysmorphologies |
T3058 |
322-323 |
. |
denotes |
. |
T3059 |
323-456 |
sentence |
denotes |
These included various head and craniofacial malformations, such as exencephaly, cleft palate and abnormal head shape (Figure 1f,g). |
T3060 |
324-329 |
DT |
denotes |
These |
T3061 |
330-338 |
VBD |
denotes |
included |
T3062 |
339-346 |
JJ |
denotes |
various |
T3064 |
347-351 |
NN |
denotes |
head |
T3065 |
352-355 |
CC |
denotes |
and |
T3066 |
356-368 |
JJ |
denotes |
craniofacial |
T3063 |
369-382 |
NNS |
denotes |
malformations |
T3067 |
382-384 |
, |
denotes |
, |
T3068 |
384-388 |
JJ |
denotes |
such |
T3069 |
389-391 |
IN |
denotes |
as |
T3070 |
392-403 |
NN |
denotes |
exencephaly |
T3071 |
403-405 |
, |
denotes |
, |
T3072 |
405-410 |
JJ |
denotes |
cleft |
T3073 |
411-417 |
NN |
denotes |
palate |
T3074 |
418-421 |
CC |
denotes |
and |
T3075 |
422-430 |
JJ |
denotes |
abnormal |
T3077 |
431-435 |
NN |
denotes |
head |
T3076 |
436-441 |
NN |
denotes |
shape |
T3078 |
442-443 |
-LRB- |
denotes |
( |
T3080 |
443-449 |
NN |
denotes |
Figure |
T3081 |
450-452 |
NN |
denotes |
1f |
T3082 |
452-453 |
, |
denotes |
, |
T3079 |
453-454 |
NN |
denotes |
g |
T3083 |
454-455 |
-RRB- |
denotes |
) |
T3084 |
455-456 |
. |
denotes |
. |
T3085 |
456-557 |
sentence |
denotes |
Gross inspection revealed that eye development was severely affected in 14.1% of homozygous embryos. |
T3086 |
457-462 |
JJ |
denotes |
Gross |
T3087 |
463-473 |
NN |
denotes |
inspection |
T3088 |
474-482 |
VBD |
denotes |
revealed |
T3089 |
483-487 |
IN |
denotes |
that |
T3091 |
488-491 |
NN |
denotes |
eye |
T3092 |
492-503 |
NN |
denotes |
development |
T3093 |
504-507 |
VBD |
denotes |
was |
T3094 |
508-516 |
RB |
denotes |
severely |
T3090 |
517-525 |
VBN |
denotes |
affected |
T3095 |
526-528 |
IN |
denotes |
in |
T3096 |
529-533 |
CD |
denotes |
14.1 |
T3097 |
533-534 |
NN |
denotes |
% |
T3098 |
535-537 |
IN |
denotes |
of |
T3099 |
538-548 |
JJ |
denotes |
homozygous |
T3100 |
549-556 |
NNS |
denotes |
embryos |
T3101 |
556-557 |
. |
denotes |
. |
T3102 |
557-716 |
sentence |
denotes |
The affected animals displayed a complete unilateral or bilateral absence of the eyes (Table 1) that was never detected in Ptdsr +/+ or Ptdsr +/- littermates. |
T3103 |
558-561 |
DT |
denotes |
The |
T3105 |
562-570 |
VBN |
denotes |
affected |
T3104 |
571-578 |
NNS |
denotes |
animals |
T3106 |
579-588 |
VBD |
denotes |
displayed |
T3107 |
589-590 |
DT |
denotes |
a |
T3109 |
591-599 |
JJ |
denotes |
complete |
T3110 |
600-610 |
JJ |
denotes |
unilateral |
T3111 |
611-613 |
CC |
denotes |
or |
T3112 |
614-623 |
JJ |
denotes |
bilateral |
T3108 |
624-631 |
NN |
denotes |
absence |
T3113 |
632-634 |
IN |
denotes |
of |
T3114 |
635-638 |
DT |
denotes |
the |
T3115 |
639-643 |
NNS |
denotes |
eyes |
T3116 |
644-645 |
-LRB- |
denotes |
( |
T3117 |
645-650 |
NN |
denotes |
Table |
T3118 |
651-652 |
CD |
denotes |
1 |
T3119 |
652-653 |
-RRB- |
denotes |
) |
T3120 |
654-658 |
WDT |
denotes |
that |
T3122 |
659-662 |
VBD |
denotes |
was |
T3123 |
663-668 |
RB |
denotes |
never |
T3121 |
669-677 |
VBN |
denotes |
detected |
T3124 |
678-680 |
IN |
denotes |
in |
T3125 |
681-686 |
NN |
denotes |
Ptdsr |
T3127 |
687-688 |
SYM |
denotes |
+ |
T3128 |
688-689 |
HYPH |
denotes |
/ |
T3129 |
689-690 |
SYM |
denotes |
+ |
T3130 |
691-693 |
CC |
denotes |
or |
T3131 |
694-699 |
NN |
denotes |
Ptdsr |
T3132 |
700-701 |
SYM |
denotes |
+ |
T3133 |
701-702 |
HYPH |
denotes |
/ |
T3134 |
702-703 |
SYM |
denotes |
- |
T3126 |
704-715 |
NNS |
denotes |
littermates |
T3135 |
715-716 |
. |
denotes |
. |
T3136 |
716-820 |
sentence |
denotes |
Furthermore, homozygous embryos harvested between E12.5 and E15.5 had subcutaneous edema (Figure 1f,g). |
T3137 |
717-728 |
RB |
denotes |
Furthermore |
T3139 |
728-730 |
, |
denotes |
, |
T3140 |
730-740 |
JJ |
denotes |
homozygous |
T3141 |
741-748 |
NNS |
denotes |
embryos |
T3142 |
749-758 |
VBN |
denotes |
harvested |
T3143 |
759-766 |
IN |
denotes |
between |
T3144 |
767-772 |
NN |
denotes |
E12.5 |
T3145 |
773-776 |
CC |
denotes |
and |
T3146 |
777-782 |
NN |
denotes |
E15.5 |
T3138 |
783-786 |
VBD |
denotes |
had |
T3147 |
787-799 |
JJ |
denotes |
subcutaneous |
T3148 |
800-805 |
NN |
denotes |
edema |
T3149 |
806-807 |
-LRB- |
denotes |
( |
T3151 |
807-813 |
NN |
denotes |
Figure |
T3152 |
814-816 |
NN |
denotes |
1f |
T3153 |
816-817 |
, |
denotes |
, |
T3150 |
817-818 |
NN |
denotes |
g |
T3154 |
818-819 |
-RRB- |
denotes |
) |
T3155 |
819-820 |
. |
denotes |
. |
T3156 |
820-948 |
sentence |
denotes |
Because we were able to recover Ptdsr -/- embryos until E18.5, we investigated whether Ptdsr-knockout mice could be born alive. |
T3157 |
821-828 |
IN |
denotes |
Because |
T3159 |
829-831 |
PRP |
denotes |
we |
T3158 |
832-836 |
VBD |
denotes |
were |
T3161 |
837-841 |
JJ |
denotes |
able |
T3162 |
842-844 |
TO |
denotes |
to |
T3163 |
845-852 |
VB |
denotes |
recover |
T3164 |
853-858 |
NN |
denotes |
Ptdsr |
T3166 |
859-860 |
SYM |
denotes |
- |
T3167 |
860-861 |
HYPH |
denotes |
/ |
T3168 |
861-862 |
SYM |
denotes |
- |
T3165 |
863-870 |
NNS |
denotes |
embryos |
T3169 |
871-876 |
IN |
denotes |
until |
T3170 |
877-882 |
NN |
denotes |
E18.5 |
T3171 |
882-884 |
, |
denotes |
, |
T3172 |
884-886 |
PRP |
denotes |
we |
T3160 |
887-899 |
VBD |
denotes |
investigated |
T3173 |
900-907 |
IN |
denotes |
whether |
T3175 |
908-913 |
NN |
denotes |
Ptdsr |
T3177 |
913-914 |
HYPH |
denotes |
- |
T3176 |
914-922 |
NN |
denotes |
knockout |
T3178 |
923-927 |
NNS |
denotes |
mice |
T3179 |
928-933 |
MD |
denotes |
could |
T3180 |
934-936 |
VB |
denotes |
be |
T3174 |
937-941 |
VBN |
denotes |
born |
T3181 |
942-947 |
JJ |
denotes |
alive |
T3182 |
947-948 |
. |
denotes |
. |
T3183 |
948-1099 |
sentence |
denotes |
Careful observation of timed matings allowed us to recover Ptdsr -/- neonates, but homozygous pups died during delivery or within minutes after birth. |
T3184 |
949-956 |
JJ |
denotes |
Careful |
T3185 |
957-968 |
NN |
denotes |
observation |
T3187 |
969-971 |
IN |
denotes |
of |
T3188 |
972-977 |
VBN |
denotes |
timed |
T3189 |
978-985 |
NNS |
denotes |
matings |
T3186 |
986-993 |
VBD |
denotes |
allowed |
T3190 |
994-996 |
PRP |
denotes |
us |
T3192 |
997-999 |
TO |
denotes |
to |
T3191 |
1000-1007 |
VB |
denotes |
recover |
T3193 |
1008-1013 |
NN |
denotes |
Ptdsr |
T3195 |
1014-1015 |
SYM |
denotes |
- |
T3196 |
1015-1016 |
HYPH |
denotes |
/ |
T3197 |
1016-1017 |
SYM |
denotes |
- |
T3194 |
1018-1026 |
NNS |
denotes |
neonates |
T3198 |
1026-1028 |
, |
denotes |
, |
T3199 |
1028-1031 |
CC |
denotes |
but |
T3200 |
1032-1042 |
JJ |
denotes |
homozygous |
T3201 |
1043-1047 |
NNS |
denotes |
pups |
T3202 |
1048-1052 |
VBD |
denotes |
died |
T3203 |
1053-1059 |
IN |
denotes |
during |
T3204 |
1060-1068 |
NN |
denotes |
delivery |
T3205 |
1069-1071 |
CC |
denotes |
or |
T3206 |
1072-1078 |
IN |
denotes |
within |
T3207 |
1079-1086 |
NNS |
denotes |
minutes |
T3208 |
1087-1092 |
IN |
denotes |
after |
T3209 |
1093-1098 |
NN |
denotes |
birth |
T3210 |
1098-1099 |
. |
denotes |
. |
T3211 |
1099-1210 |
sentence |
denotes |
Ptdsr-deficient neonates were also growth-retarded, had a pale appearance and displayed various malformations. |
T3212 |
1100-1105 |
NN |
denotes |
Ptdsr |
T3214 |
1105-1106 |
HYPH |
denotes |
- |
T3213 |
1106-1115 |
JJ |
denotes |
deficient |
T3215 |
1116-1124 |
NNS |
denotes |
neonates |
T3216 |
1125-1129 |
VBD |
denotes |
were |
T3217 |
1130-1134 |
RB |
denotes |
also |
T3218 |
1135-1141 |
NN |
denotes |
growth |
T3220 |
1141-1142 |
HYPH |
denotes |
- |
T3219 |
1142-1150 |
VBN |
denotes |
retarded |
T3221 |
1150-1152 |
, |
denotes |
, |
T3222 |
1152-1155 |
VBD |
denotes |
had |
T3223 |
1156-1157 |
DT |
denotes |
a |
T3225 |
1158-1162 |
JJ |
denotes |
pale |
T3224 |
1163-1173 |
NN |
denotes |
appearance |
T3226 |
1174-1177 |
CC |
denotes |
and |
T3227 |
1178-1187 |
VBD |
denotes |
displayed |
T3228 |
1188-1195 |
JJ |
denotes |
various |
T3229 |
1196-1209 |
NNS |
denotes |
malformations |
T3230 |
1209-1210 |
. |
denotes |
. |
T3231 |
1210-1308 |
sentence |
denotes |
These included cleft palate, abnormal head shape, absence of eyes and edematous skin (Figure 1h). |
T3232 |
1211-1216 |
DT |
denotes |
These |
T3233 |
1217-1225 |
VBD |
denotes |
included |
T3234 |
1226-1231 |
JJ |
denotes |
cleft |
T3235 |
1232-1238 |
NN |
denotes |
palate |
T3236 |
1238-1240 |
, |
denotes |
, |
T3237 |
1240-1248 |
JJ |
denotes |
abnormal |
T3239 |
1249-1253 |
NN |
denotes |
head |
T3238 |
1254-1259 |
NN |
denotes |
shape |
T3240 |
1259-1261 |
, |
denotes |
, |
T3241 |
1261-1268 |
NN |
denotes |
absence |
T3242 |
1269-1271 |
IN |
denotes |
of |
T3243 |
1272-1276 |
NNS |
denotes |
eyes |
T3244 |
1277-1280 |
CC |
denotes |
and |
T3245 |
1281-1290 |
JJ |
denotes |
edematous |
T3246 |
1291-1295 |
NN |
denotes |
skin |
T3247 |
1296-1297 |
-LRB- |
denotes |
( |
T3249 |
1297-1303 |
NN |
denotes |
Figure |
T3248 |
1304-1306 |
NN |
denotes |
1h |
T3250 |
1306-1307 |
-RRB- |
denotes |
) |
T3251 |
1307-1308 |
. |
denotes |
. |
T3252 |
1308-1426 |
sentence |
denotes |
Thus, deletion of the Ptdsr gene resulted in perinatal lethality with variable severity and penetrance of phenotypes. |
T3253 |
1309-1313 |
RB |
denotes |
Thus |
T3255 |
1313-1315 |
, |
denotes |
, |
T3256 |
1315-1323 |
NN |
denotes |
deletion |
T3257 |
1324-1326 |
IN |
denotes |
of |
T3258 |
1327-1330 |
DT |
denotes |
the |
T3260 |
1331-1336 |
NN |
denotes |
Ptdsr |
T3259 |
1337-1341 |
NN |
denotes |
gene |
T3254 |
1342-1350 |
VBD |
denotes |
resulted |
T3261 |
1351-1353 |
IN |
denotes |
in |
T3262 |
1354-1363 |
JJ |
denotes |
perinatal |
T3263 |
1364-1373 |
NN |
denotes |
lethality |
T3264 |
1374-1378 |
IN |
denotes |
with |
T3265 |
1379-1387 |
JJ |
denotes |
variable |
T3266 |
1388-1396 |
NN |
denotes |
severity |
T3267 |
1397-1400 |
CC |
denotes |
and |
T3268 |
1401-1411 |
NN |
denotes |
penetrance |
T3269 |
1412-1414 |
IN |
denotes |
of |
T3270 |
1415-1425 |
NNS |
denotes |
phenotypes |
T3271 |
1425-1426 |
. |
denotes |
. |
R1626 |
T2996 |
T2997 |
prep |
From,were |
R1627 |
T2998 |
T2996 |
pobj |
E9.5,From |
R1628 |
T2999 |
T2996 |
prep |
to,From |
R1629 |
T3000 |
T2999 |
pobj |
E12.5,to |
R1630 |
T3001 |
T2997 |
punct |
", ",were |
R1631 |
T3002 |
T3003 |
nmod |
Ptdsr,embryos |
R1632 |
T3003 |
T2997 |
nsubj |
embryos,were |
R1633 |
T3004 |
T3002 |
punct |
-,Ptdsr |
R1634 |
T3005 |
T3002 |
punct |
/,Ptdsr |
R1635 |
T3006 |
T3002 |
punct |
-,Ptdsr |
R1636 |
T3007 |
T2997 |
acomp |
viable,were |
R1637 |
T3008 |
T3007 |
cc |
and,viable |
R1638 |
T3009 |
T3007 |
conj |
of,viable |
R1639 |
T3010 |
T3011 |
amod |
normal,size |
R1640 |
T3011 |
T3009 |
pobj |
size,of |
R1641 |
T3012 |
T2997 |
punct |
.,were |
R1642 |
T3014 |
T3015 |
prep |
At,showed |
R1643 |
T3016 |
T3014 |
pobj |
E13.5,At |
R1644 |
T3017 |
T3014 |
cc |
and,At |
R1645 |
T3018 |
T3014 |
conj |
thereafter,At |
R1646 |
T3019 |
T3015 |
punct |
", ",showed |
R1647 |
T3020 |
T3015 |
advmod |
however,showed |
R1648 |
T3021 |
T3015 |
punct |
", ",showed |
R1649 |
T3022 |
T3023 |
amod |
most,embryos |
R1650 |
T3023 |
T3015 |
nsubj |
embryos,showed |
R1651 |
T3024 |
T3023 |
nmod |
Ptdsr,embryos |
R1652 |
T3025 |
T3024 |
punct |
-,Ptdsr |
R1653 |
T3026 |
T3024 |
punct |
/,Ptdsr |
R1654 |
T3027 |
T3024 |
punct |
-,Ptdsr |
R1655 |
T3028 |
T3029 |
amod |
morphological,abnormalities |
R1656 |
T3029 |
T3015 |
dobj |
abnormalities,showed |
R1657 |
T3030 |
T3031 |
punct |
(,Table |
R1658 |
T3031 |
T3015 |
parataxis |
Table,showed |
R1659 |
T3032 |
T3031 |
nummod |
1,Table |
R1660 |
T3033 |
T3031 |
punct |
),Table |
R1661 |
T3034 |
T3015 |
punct |
.,showed |
R1662 |
T3036 |
T3037 |
det |
All,embryos |
R1663 |
T3037 |
T3039 |
nsubj |
embryos,were |
R1664 |
T3038 |
T3037 |
amod |
homozygous,embryos |
R1665 |
T3040 |
T3037 |
acl |
harvested,embryos |
R1666 |
T3041 |
T3042 |
npadvmod |
growth,retarded |
R1667 |
T3042 |
T3039 |
acomp |
retarded,were |
R1668 |
T3043 |
T3042 |
punct |
-,retarded |
R1669 |
T3044 |
T3039 |
prep |
from,were |
R1670 |
T3045 |
T3044 |
pobj |
E13.5,from |
R1671 |
T3046 |
T3045 |
advmod |
onwards,E13.5 |
R1672 |
T3047 |
T3039 |
punct |
", ",were |
R1673 |
T3048 |
T3039 |
conj |
had,were |
R1674 |
T3049 |
T3050 |
det |
a,appearance |
R1675 |
T3050 |
T3048 |
dobj |
appearance,had |
R1676 |
T3051 |
T3050 |
amod |
pale,appearance |
R1677 |
T3052 |
T3048 |
punct |
", ",had |
R1678 |
T3053 |
T3048 |
cc |
and,had |
R1679 |
T3054 |
T3048 |
conj |
displayed,had |
R1680 |
T3055 |
T3056 |
amod |
multiple,dysmorphologies |
R1681 |
T3056 |
T3054 |
dobj |
dysmorphologies,displayed |
R1682 |
T3057 |
T3056 |
amod |
developmental,dysmorphologies |
R1683 |
T3058 |
T3039 |
punct |
.,were |
R1684 |
T3060 |
T3061 |
nsubj |
These,included |
R1685 |
T3062 |
T3063 |
amod |
various,malformations |
R1686 |
T3063 |
T3061 |
dobj |
malformations,included |
R1687 |
T3064 |
T3063 |
nmod |
head,malformations |
R1688 |
T3065 |
T3064 |
cc |
and,head |
R1689 |
T3066 |
T3064 |
conj |
craniofacial,head |
R1690 |
T3067 |
T3063 |
punct |
", ",malformations |
R1691 |
T3068 |
T3069 |
amod |
such,as |
R1692 |
T3069 |
T3063 |
prep |
as,malformations |
R1693 |
T3070 |
T3069 |
pobj |
exencephaly,as |
R1694 |
T3071 |
T3070 |
punct |
", ",exencephaly |
R1695 |
T3072 |
T3073 |
amod |
cleft,palate |
R1696 |
T3073 |
T3070 |
conj |
palate,exencephaly |
R1697 |
T3074 |
T3073 |
cc |
and,palate |
R1698 |
T3075 |
T3076 |
amod |
abnormal,shape |
R1699 |
T3076 |
T3073 |
conj |
shape,palate |
R1700 |
T3077 |
T3076 |
compound |
head,shape |
R1701 |
T3078 |
T3079 |
punct |
(,g |
R1702 |
T3079 |
T3061 |
parataxis |
g,included |
R1703 |
T3080 |
T3079 |
nmod |
Figure,g |
R1704 |
T3081 |
T3079 |
nmod |
1f,g |
R1705 |
T3082 |
T3079 |
punct |
",",g |
R1706 |
T3083 |
T3079 |
punct |
),g |
R1707 |
T3084 |
T3061 |
punct |
.,included |
R1708 |
T3086 |
T3087 |
amod |
Gross,inspection |
R1709 |
T3087 |
T3088 |
nsubj |
inspection,revealed |
R1710 |
T3089 |
T3090 |
mark |
that,affected |
R1711 |
T3090 |
T3088 |
ccomp |
affected,revealed |
R1712 |
T3091 |
T3092 |
compound |
eye,development |
R1713 |
T3092 |
T3090 |
nsubjpass |
development,affected |
R1714 |
T3093 |
T3090 |
auxpass |
was,affected |
R1715 |
T3094 |
T3090 |
advmod |
severely,affected |
R1716 |
T3095 |
T3090 |
prep |
in,affected |
R1717 |
T3096 |
T3097 |
nummod |
14.1,% |
R1718 |
T3097 |
T3095 |
pobj |
%,in |
R1719 |
T3098 |
T3097 |
prep |
of,% |
R1720 |
T3099 |
T3100 |
amod |
homozygous,embryos |
R1721 |
T3100 |
T3098 |
pobj |
embryos,of |
R1722 |
T3101 |
T3088 |
punct |
.,revealed |
R1723 |
T3103 |
T3104 |
det |
The,animals |
R1724 |
T3104 |
T3106 |
nsubj |
animals,displayed |
R1725 |
T3105 |
T3104 |
amod |
affected,animals |
R1726 |
T3107 |
T3108 |
det |
a,absence |
R1727 |
T3108 |
T3106 |
dobj |
absence,displayed |
R1728 |
T3109 |
T3108 |
amod |
complete,absence |
R1729 |
T3110 |
T3108 |
amod |
unilateral,absence |
R1730 |
T3111 |
T3110 |
cc |
or,unilateral |
R1731 |
T3112 |
T3110 |
conj |
bilateral,unilateral |
R1732 |
T3113 |
T3108 |
prep |
of,absence |
R1733 |
T3114 |
T3115 |
det |
the,eyes |
R1734 |
T3115 |
T3113 |
pobj |
eyes,of |
R1735 |
T3116 |
T3117 |
punct |
(,Table |
R1736 |
T3117 |
T3108 |
parataxis |
Table,absence |
R1737 |
T3118 |
T3117 |
nummod |
1,Table |
R1738 |
T3119 |
T3117 |
punct |
),Table |
R1739 |
T3120 |
T3121 |
dep |
that,detected |
R1740 |
T3121 |
T3108 |
relcl |
detected,absence |
R1741 |
T3122 |
T3121 |
auxpass |
was,detected |
R1742 |
T3123 |
T3121 |
neg |
never,detected |
R1743 |
T3124 |
T3121 |
prep |
in,detected |
R1744 |
T3125 |
T3126 |
nmod |
Ptdsr,littermates |
R1745 |
T3126 |
T3124 |
pobj |
littermates,in |
R1746 |
T3127 |
T3125 |
punct |
+,Ptdsr |
R1747 |
T3128 |
T3125 |
punct |
/,Ptdsr |
R1748 |
T3129 |
T3125 |
punct |
+,Ptdsr |
R1749 |
T3130 |
T3125 |
cc |
or,Ptdsr |
R1750 |
T3131 |
T3125 |
conj |
Ptdsr,Ptdsr |
R1751 |
T3132 |
T3131 |
punct |
+,Ptdsr |
R1752 |
T3133 |
T3131 |
punct |
/,Ptdsr |
R1753 |
T3134 |
T3131 |
punct |
-,Ptdsr |
R1754 |
T3135 |
T3106 |
punct |
.,displayed |
R1755 |
T3137 |
T3138 |
advmod |
Furthermore,had |
R1756 |
T3139 |
T3138 |
punct |
", ",had |
R1757 |
T3140 |
T3141 |
amod |
homozygous,embryos |
R1758 |
T3141 |
T3138 |
nsubj |
embryos,had |
R1759 |
T3142 |
T3141 |
acl |
harvested,embryos |
R1760 |
T3143 |
T3142 |
prep |
between,harvested |
R1761 |
T3144 |
T3143 |
pobj |
E12.5,between |
R1762 |
T3145 |
T3144 |
cc |
and,E12.5 |
R1763 |
T3146 |
T3144 |
conj |
E15.5,E12.5 |
R1764 |
T3147 |
T3148 |
amod |
subcutaneous,edema |
R1765 |
T3148 |
T3138 |
dobj |
edema,had |
R1766 |
T3149 |
T3150 |
punct |
(,g |
R1767 |
T3150 |
T3138 |
parataxis |
g,had |
R1768 |
T3151 |
T3150 |
nmod |
Figure,g |
R1769 |
T3152 |
T3150 |
nmod |
1f,g |
R1770 |
T3153 |
T3150 |
punct |
",",g |
R1771 |
T3154 |
T3150 |
punct |
),g |
R1772 |
T3155 |
T3138 |
punct |
.,had |
R1773 |
T3157 |
T3158 |
mark |
Because,were |
R1774 |
T3158 |
T3160 |
advcl |
were,investigated |
R1775 |
T3159 |
T3158 |
nsubj |
we,were |
R1776 |
T3161 |
T3158 |
acomp |
able,were |
R1777 |
T3162 |
T3163 |
aux |
to,recover |
R1778 |
T3163 |
T3161 |
xcomp |
recover,able |
R1779 |
T3164 |
T3165 |
nmod |
Ptdsr,embryos |
R1780 |
T3165 |
T3163 |
dobj |
embryos,recover |
R1781 |
T3166 |
T3164 |
punct |
-,Ptdsr |
R1782 |
T3167 |
T3164 |
punct |
/,Ptdsr |
R1783 |
T3168 |
T3164 |
punct |
-,Ptdsr |
R1784 |
T3169 |
T3163 |
prep |
until,recover |
R1785 |
T3170 |
T3169 |
pobj |
E18.5,until |
R1786 |
T3171 |
T3160 |
punct |
", ",investigated |
R1787 |
T3172 |
T3160 |
nsubj |
we,investigated |
R1788 |
T3173 |
T3174 |
mark |
whether,born |
R1789 |
T3174 |
T3160 |
ccomp |
born,investigated |
R1790 |
T3175 |
T3176 |
compound |
Ptdsr,knockout |
R1791 |
T3176 |
T3178 |
compound |
knockout,mice |
R1792 |
T3177 |
T3176 |
punct |
-,knockout |
R1793 |
T3178 |
T3174 |
nsubjpass |
mice,born |
R1794 |
T3179 |
T3174 |
aux |
could,born |
R1795 |
T3180 |
T3174 |
auxpass |
be,born |
R1796 |
T3181 |
T3174 |
advcl |
alive,born |
R1797 |
T3182 |
T3160 |
punct |
.,investigated |
R1798 |
T3184 |
T3185 |
amod |
Careful,observation |
R1799 |
T3185 |
T3186 |
nsubj |
observation,allowed |
R1800 |
T3187 |
T3185 |
prep |
of,observation |
R1801 |
T3188 |
T3189 |
amod |
timed,matings |
R1802 |
T3189 |
T3187 |
pobj |
matings,of |
R1803 |
T3190 |
T3191 |
nsubj |
us,recover |
R1804 |
T3191 |
T3186 |
ccomp |
recover,allowed |
R1805 |
T3192 |
T3191 |
aux |
to,recover |
R1806 |
T3193 |
T3194 |
nmod |
Ptdsr,neonates |
R1807 |
T3194 |
T3191 |
dobj |
neonates,recover |
R1808 |
T3195 |
T3193 |
punct |
-,Ptdsr |
R1809 |
T3196 |
T3193 |
punct |
/,Ptdsr |
R1810 |
T3197 |
T3193 |
punct |
-,Ptdsr |
R1811 |
T3198 |
T3186 |
punct |
", ",allowed |
R1812 |
T3199 |
T3186 |
cc |
but,allowed |
R1813 |
T3200 |
T3201 |
amod |
homozygous,pups |
R1814 |
T3201 |
T3202 |
nsubj |
pups,died |
R1815 |
T3202 |
T3186 |
conj |
died,allowed |
R1816 |
T3203 |
T3202 |
prep |
during,died |
R1817 |
T3204 |
T3203 |
pobj |
delivery,during |
R1818 |
T3205 |
T3203 |
cc |
or,during |
R1819 |
T3206 |
T3203 |
conj |
within,during |
R1820 |
T3207 |
T3206 |
pobj |
minutes,within |
R1821 |
T3208 |
T3207 |
prep |
after,minutes |
R1822 |
T3209 |
T3208 |
pobj |
birth,after |
R1823 |
T3210 |
T3202 |
punct |
.,died |
R1824 |
T3212 |
T3213 |
npadvmod |
Ptdsr,deficient |
R1825 |
T3213 |
T3215 |
amod |
deficient,neonates |
R1826 |
T3214 |
T3213 |
punct |
-,deficient |
R1827 |
T3215 |
T3216 |
nsubj |
neonates,were |
R1828 |
T3217 |
T3216 |
advmod |
also,were |
R1829 |
T3218 |
T3219 |
npadvmod |
growth,retarded |
R1830 |
T3219 |
T3216 |
acomp |
retarded,were |
R1831 |
T3220 |
T3219 |
punct |
-,retarded |
R1832 |
T3221 |
T3216 |
punct |
", ",were |
R1833 |
T3222 |
T3216 |
conj |
had,were |
R1834 |
T3223 |
T3224 |
det |
a,appearance |
R1835 |
T3224 |
T3222 |
dobj |
appearance,had |
R1836 |
T3225 |
T3224 |
amod |
pale,appearance |
R1837 |
T3226 |
T3222 |
cc |
and,had |
R1838 |
T3227 |
T3222 |
conj |
displayed,had |
R1839 |
T3228 |
T3229 |
amod |
various,malformations |
R1840 |
T3229 |
T3227 |
dobj |
malformations,displayed |
R1841 |
T3230 |
T3216 |
punct |
.,were |
R1842 |
T3232 |
T3233 |
nsubj |
These,included |
R1843 |
T3234 |
T3235 |
amod |
cleft,palate |
R1844 |
T3235 |
T3233 |
dobj |
palate,included |
R1845 |
T3236 |
T3235 |
punct |
", ",palate |
R1846 |
T3237 |
T3238 |
amod |
abnormal,shape |
R1847 |
T3238 |
T3235 |
conj |
shape,palate |
R1848 |
T3239 |
T3238 |
compound |
head,shape |
R1849 |
T3240 |
T3238 |
punct |
", ",shape |
R1850 |
T3241 |
T3238 |
conj |
absence,shape |
R1851 |
T3242 |
T3241 |
prep |
of,absence |
R1852 |
T3243 |
T3242 |
pobj |
eyes,of |
R1853 |
T3244 |
T3241 |
cc |
and,absence |
R1854 |
T3245 |
T3246 |
amod |
edematous,skin |
R1855 |
T3246 |
T3241 |
conj |
skin,absence |
R1856 |
T3247 |
T3248 |
punct |
(,1h |
R1857 |
T3248 |
T3233 |
parataxis |
1h,included |
R1858 |
T3249 |
T3248 |
compound |
Figure,1h |
R1859 |
T3250 |
T3248 |
punct |
),1h |
R1860 |
T3251 |
T3233 |
punct |
.,included |
R1861 |
T3253 |
T3254 |
advmod |
Thus,resulted |
R1862 |
T3255 |
T3254 |
punct |
", ",resulted |
R1863 |
T3256 |
T3254 |
nsubj |
deletion,resulted |
R1864 |
T3257 |
T3256 |
prep |
of,deletion |
R1865 |
T3258 |
T3259 |
det |
the,gene |
R1866 |
T3259 |
T3257 |
pobj |
gene,of |
R1867 |
T3260 |
T3259 |
compound |
Ptdsr,gene |
R1868 |
T3261 |
T3254 |
prep |
in,resulted |
R1869 |
T3262 |
T3263 |
amod |
perinatal,lethality |
R1870 |
T3263 |
T3261 |
pobj |
lethality,in |
R1871 |
T3264 |
T3254 |
prep |
with,resulted |
R1872 |
T3265 |
T3266 |
amod |
variable,severity |
R1873 |
T3266 |
T3264 |
pobj |
severity,with |
R1874 |
T3267 |
T3266 |
cc |
and,severity |
R1875 |
T3268 |
T3266 |
conj |
penetrance,severity |
R1876 |
T3269 |
T3266 |
prep |
of,severity |
R1877 |
T3270 |
T3269 |
pobj |
phenotypes,of |
R1878 |
T3271 |
T3254 |
punct |
.,resulted |