Id |
Subject |
Object |
Predicate |
Lexical cue |
T353 |
0-7 |
NNS |
denotes |
Results |
T354 |
7-193 |
sentence |
denotes |
Ablation of Ptdsr function in mice causes perinatal lethality, growth retardation and a delay in terminal differentiation of the kidney, intestine, liver and lungs during embryogenesis. |
T355 |
8-16 |
NN |
denotes |
Ablation |
T357 |
17-19 |
IN |
denotes |
of |
T358 |
20-25 |
NN |
denotes |
Ptdsr |
T359 |
26-34 |
NN |
denotes |
function |
T360 |
35-37 |
IN |
denotes |
in |
T361 |
38-42 |
NNS |
denotes |
mice |
T356 |
43-49 |
VBZ |
denotes |
causes |
T362 |
50-59 |
JJ |
denotes |
perinatal |
T363 |
60-69 |
NN |
denotes |
lethality |
T364 |
69-71 |
, |
denotes |
, |
T365 |
71-77 |
NN |
denotes |
growth |
T366 |
78-89 |
NN |
denotes |
retardation |
T367 |
90-93 |
CC |
denotes |
and |
T368 |
94-95 |
DT |
denotes |
a |
T369 |
96-101 |
NN |
denotes |
delay |
T370 |
102-104 |
IN |
denotes |
in |
T371 |
105-113 |
JJ |
denotes |
terminal |
T372 |
114-129 |
NN |
denotes |
differentiation |
T373 |
130-132 |
IN |
denotes |
of |
T374 |
133-136 |
DT |
denotes |
the |
T375 |
137-143 |
NN |
denotes |
kidney |
T376 |
143-145 |
, |
denotes |
, |
T377 |
145-154 |
NN |
denotes |
intestine |
T378 |
154-156 |
, |
denotes |
, |
T379 |
156-161 |
NN |
denotes |
liver |
T380 |
162-165 |
CC |
denotes |
and |
T381 |
166-171 |
NNS |
denotes |
lungs |
T382 |
172-178 |
IN |
denotes |
during |
T383 |
179-192 |
NN |
denotes |
embryogenesis |
T384 |
192-193 |
. |
denotes |
. |
T385 |
193-347 |
sentence |
denotes |
Moreover, eye development can be severely disturbed, ranging from defects in retinal differentiation to complete unilateral or bilateral absence of eyes. |
T386 |
194-202 |
RB |
denotes |
Moreover |
T388 |
202-204 |
, |
denotes |
, |
T389 |
204-207 |
NN |
denotes |
eye |
T390 |
208-219 |
NN |
denotes |
development |
T391 |
220-223 |
MD |
denotes |
can |
T392 |
224-226 |
VB |
denotes |
be |
T393 |
227-235 |
RB |
denotes |
severely |
T387 |
236-245 |
VBN |
denotes |
disturbed |
T394 |
245-247 |
, |
denotes |
, |
T395 |
247-254 |
VBG |
denotes |
ranging |
T396 |
255-259 |
IN |
denotes |
from |
T397 |
260-267 |
NNS |
denotes |
defects |
T398 |
268-270 |
IN |
denotes |
in |
T399 |
271-278 |
JJ |
denotes |
retinal |
T400 |
279-294 |
NN |
denotes |
differentiation |
T401 |
295-297 |
IN |
denotes |
to |
T402 |
298-306 |
JJ |
denotes |
complete |
T404 |
307-317 |
JJ |
denotes |
unilateral |
T405 |
318-320 |
CC |
denotes |
or |
T406 |
321-330 |
JJ |
denotes |
bilateral |
T403 |
331-338 |
NN |
denotes |
absence |
T407 |
339-341 |
IN |
denotes |
of |
T408 |
342-346 |
NNS |
denotes |
eyes |
T409 |
346-347 |
. |
denotes |
. |
T410 |
347-477 |
sentence |
denotes |
Ptdsr -/- mice with anophthalmia develop novel lesions, with induction of ectopic retinal-pigmented epithelium in nasal cavities. |
T411 |
348-353 |
NN |
denotes |
Ptdsr |
T413 |
354-355 |
SYM |
denotes |
- |
T414 |
355-356 |
HYPH |
denotes |
/ |
T415 |
356-357 |
SYM |
denotes |
- |
T412 |
358-362 |
NNS |
denotes |
mice |
T417 |
363-367 |
IN |
denotes |
with |
T418 |
368-380 |
NN |
denotes |
anophthalmia |
T416 |
381-388 |
VBP |
denotes |
develop |
T419 |
389-394 |
JJ |
denotes |
novel |
T420 |
395-402 |
NNS |
denotes |
lesions |
T421 |
402-404 |
, |
denotes |
, |
T422 |
404-408 |
IN |
denotes |
with |
T423 |
409-418 |
NN |
denotes |
induction |
T424 |
419-421 |
IN |
denotes |
of |
T425 |
422-429 |
JJ |
denotes |
ectopic |
T427 |
430-437 |
RB |
denotes |
retinal |
T429 |
437-438 |
HYPH |
denotes |
- |
T428 |
438-447 |
VBN |
denotes |
pigmented |
T426 |
448-458 |
NN |
denotes |
epithelium |
T430 |
459-461 |
IN |
denotes |
in |
T431 |
462-467 |
JJ |
denotes |
nasal |
T432 |
468-476 |
NNS |
denotes |
cavities |
T433 |
476-477 |
. |
denotes |
. |
T434 |
477-801 |
sentence |
denotes |
A comprehensive investigation of apoptotic cell clearance in vivo and in vitro demonstrated that engulfment of apoptotic cells was normal in Ptdsr knockout mice, but Ptdsr-deficient macrophages were impaired in pro- and anti-inflammatory cytokine signaling after stimulation with apoptotic cells or with lipopolysaccharide. |
T435 |
478-479 |
DT |
denotes |
A |
T437 |
480-493 |
JJ |
denotes |
comprehensive |
T436 |
494-507 |
NN |
denotes |
investigation |
T439 |
508-510 |
IN |
denotes |
of |
T440 |
511-520 |
JJ |
denotes |
apoptotic |
T442 |
521-525 |
NN |
denotes |
cell |
T441 |
526-535 |
NN |
denotes |
clearance |
T443 |
536-538 |
FW |
denotes |
in |
T444 |
539-543 |
FW |
denotes |
vivo |
T445 |
544-547 |
CC |
denotes |
and |
T446 |
548-550 |
FW |
denotes |
in |
T447 |
551-556 |
FW |
denotes |
vitro |
T438 |
557-569 |
VBD |
denotes |
demonstrated |
T448 |
570-574 |
IN |
denotes |
that |
T450 |
575-585 |
NN |
denotes |
engulfment |
T451 |
586-588 |
IN |
denotes |
of |
T452 |
589-598 |
JJ |
denotes |
apoptotic |
T453 |
599-604 |
NNS |
denotes |
cells |
T449 |
605-608 |
VBD |
denotes |
was |
T454 |
609-615 |
JJ |
denotes |
normal |
T455 |
616-618 |
IN |
denotes |
in |
T456 |
619-624 |
NN |
denotes |
Ptdsr |
T458 |
625-633 |
NN |
denotes |
knockout |
T457 |
634-638 |
NNS |
denotes |
mice |
T459 |
638-640 |
, |
denotes |
, |
T460 |
640-643 |
CC |
denotes |
but |
T461 |
644-649 |
NN |
denotes |
Ptdsr |
T463 |
649-650 |
HYPH |
denotes |
- |
T462 |
650-659 |
JJ |
denotes |
deficient |
T464 |
660-671 |
NNS |
denotes |
macrophages |
T466 |
672-676 |
VBD |
denotes |
were |
T465 |
677-685 |
VBN |
denotes |
impaired |
T467 |
686-688 |
IN |
denotes |
in |
T468 |
689-692 |
AFX |
denotes |
pro |
T470 |
692-693 |
HYPH |
denotes |
- |
T471 |
694-697 |
CC |
denotes |
and |
T469 |
698-715 |
JJ |
denotes |
anti-inflammatory |
T473 |
716-724 |
NN |
denotes |
cytokine |
T472 |
725-734 |
NN |
denotes |
signaling |
T474 |
735-740 |
IN |
denotes |
after |
T475 |
741-752 |
NN |
denotes |
stimulation |
T476 |
753-757 |
IN |
denotes |
with |
T477 |
758-767 |
JJ |
denotes |
apoptotic |
T478 |
768-773 |
NNS |
denotes |
cells |
T479 |
774-776 |
CC |
denotes |
or |
T480 |
777-781 |
IN |
denotes |
with |
T481 |
782-800 |
NN |
denotes |
lipopolysaccharide |
T482 |
800-801 |
. |
denotes |
. |
R100 |
T381 |
T379 |
conj |
lungs,liver |
R101 |
T382 |
T369 |
prep |
during,delay |
R102 |
T383 |
T382 |
pobj |
embryogenesis,during |
R103 |
T384 |
T356 |
punct |
.,causes |
R104 |
T386 |
T387 |
advmod |
Moreover,disturbed |
R105 |
T388 |
T387 |
punct |
", ",disturbed |
R106 |
T389 |
T390 |
compound |
eye,development |
R107 |
T390 |
T387 |
nsubjpass |
development,disturbed |
R108 |
T391 |
T387 |
aux |
can,disturbed |
R109 |
T392 |
T387 |
auxpass |
be,disturbed |
R110 |
T393 |
T387 |
advmod |
severely,disturbed |
R111 |
T394 |
T387 |
punct |
", ",disturbed |
R112 |
T395 |
T387 |
advcl |
ranging,disturbed |
R113 |
T396 |
T395 |
prep |
from,ranging |
R114 |
T397 |
T396 |
pobj |
defects,from |
R115 |
T398 |
T397 |
prep |
in,defects |
R116 |
T399 |
T400 |
amod |
retinal,differentiation |
R117 |
T400 |
T398 |
pobj |
differentiation,in |
R118 |
T401 |
T396 |
prep |
to,from |
R119 |
T402 |
T403 |
amod |
complete,absence |
R120 |
T403 |
T401 |
pobj |
absence,to |
R121 |
T404 |
T403 |
amod |
unilateral,absence |
R122 |
T405 |
T404 |
cc |
or,unilateral |
R123 |
T406 |
T404 |
conj |
bilateral,unilateral |
R124 |
T407 |
T403 |
prep |
of,absence |
R125 |
T408 |
T407 |
pobj |
eyes,of |
R126 |
T409 |
T387 |
punct |
.,disturbed |
R127 |
T411 |
T412 |
nmod |
Ptdsr,mice |
R128 |
T412 |
T416 |
nsubj |
mice,develop |
R129 |
T413 |
T411 |
punct |
-,Ptdsr |
R130 |
T414 |
T411 |
punct |
/,Ptdsr |
R131 |
T415 |
T411 |
punct |
-,Ptdsr |
R132 |
T417 |
T412 |
prep |
with,mice |
R133 |
T418 |
T417 |
pobj |
anophthalmia,with |
R134 |
T419 |
T420 |
amod |
novel,lesions |
R135 |
T420 |
T416 |
dobj |
lesions,develop |
R136 |
T421 |
T420 |
punct |
", ",lesions |
R137 |
T422 |
T420 |
prep |
with,lesions |
R138 |
T423 |
T422 |
pobj |
induction,with |
R139 |
T424 |
T423 |
prep |
of,induction |
R140 |
T425 |
T426 |
amod |
ectopic,epithelium |
R141 |
T426 |
T424 |
pobj |
epithelium,of |
R142 |
T427 |
T428 |
advmod |
retinal,pigmented |
R143 |
T428 |
T426 |
amod |
pigmented,epithelium |
R144 |
T429 |
T428 |
punct |
-,pigmented |
R145 |
T430 |
T423 |
prep |
in,induction |
R146 |
T431 |
T432 |
amod |
nasal,cavities |
R147 |
T432 |
T430 |
pobj |
cavities,in |
R148 |
T433 |
T416 |
punct |
.,develop |
R149 |
T435 |
T436 |
det |
A,investigation |
R150 |
T436 |
T438 |
nsubj |
investigation,demonstrated |
R151 |
T437 |
T436 |
amod |
comprehensive,investigation |
R152 |
T439 |
T436 |
prep |
of,investigation |
R153 |
T440 |
T441 |
amod |
apoptotic,clearance |
R154 |
T441 |
T439 |
pobj |
clearance,of |
R155 |
T442 |
T441 |
compound |
cell,clearance |
R156 |
T443 |
T444 |
advmod |
in,vivo |
R157 |
T444 |
T436 |
advmod |
vivo,investigation |
R158 |
T445 |
T444 |
cc |
and,vivo |
R159 |
T446 |
T447 |
advmod |
in,vitro |
R160 |
T447 |
T444 |
conj |
vitro,vivo |
R161 |
T448 |
T449 |
mark |
that,was |
R162 |
T449 |
T438 |
ccomp |
was,demonstrated |
R163 |
T450 |
T449 |
nsubj |
engulfment,was |
R164 |
T451 |
T450 |
prep |
of,engulfment |
R165 |
T452 |
T453 |
amod |
apoptotic,cells |
R166 |
T453 |
T451 |
pobj |
cells,of |
R167 |
T454 |
T449 |
acomp |
normal,was |
R168 |
T455 |
T449 |
prep |
in,was |
R169 |
T456 |
T457 |
compound |
Ptdsr,mice |
R170 |
T457 |
T455 |
pobj |
mice,in |
R171 |
T458 |
T457 |
compound |
knockout,mice |
R172 |
T459 |
T438 |
punct |
", ",demonstrated |
R173 |
T460 |
T438 |
cc |
but,demonstrated |
R174 |
T461 |
T462 |
npadvmod |
Ptdsr,deficient |
R175 |
T462 |
T464 |
amod |
deficient,macrophages |
R176 |
T463 |
T462 |
punct |
-,deficient |
R177 |
T464 |
T465 |
nsubjpass |
macrophages,impaired |
R178 |
T465 |
T438 |
conj |
impaired,demonstrated |
R179 |
T466 |
T465 |
auxpass |
were,impaired |
R180 |
T467 |
T465 |
prep |
in,impaired |
R181 |
T468 |
T469 |
advmod |
pro,anti-inflammatory |
R182 |
T469 |
T472 |
amod |
anti-inflammatory,signaling |
R183 |
T470 |
T469 |
punct |
-,anti-inflammatory |
R184 |
T471 |
T469 |
cc |
and,anti-inflammatory |
R185 |
T472 |
T467 |
pobj |
signaling,in |
R186 |
T473 |
T472 |
compound |
cytokine,signaling |
R187 |
T474 |
T465 |
prep |
after,impaired |
R188 |
T475 |
T474 |
pobj |
stimulation,after |
R189 |
T476 |
T475 |
prep |
with,stimulation |
R190 |
T477 |
T478 |
amod |
apoptotic,cells |
R191 |
T478 |
T476 |
pobj |
cells,with |
R192 |
T479 |
T476 |
cc |
or,with |
R193 |
T480 |
T476 |
conj |
with,with |
R194 |
T481 |
T480 |
pobj |
lipopolysaccharide,with |
R195 |
T482 |
T465 |
punct |
.,impaired |
R75 |
T355 |
T356 |
nsubj |
Ablation,causes |
R76 |
T357 |
T355 |
prep |
of,Ablation |
R77 |
T358 |
T359 |
compound |
Ptdsr,function |
R78 |
T359 |
T357 |
pobj |
function,of |
R79 |
T360 |
T355 |
prep |
in,Ablation |
R80 |
T361 |
T360 |
pobj |
mice,in |
R81 |
T362 |
T363 |
amod |
perinatal,lethality |
R82 |
T363 |
T356 |
dobj |
lethality,causes |
R83 |
T364 |
T363 |
punct |
", ",lethality |
R84 |
T365 |
T366 |
compound |
growth,retardation |
R85 |
T366 |
T363 |
conj |
retardation,lethality |
R86 |
T367 |
T366 |
cc |
and,retardation |
R87 |
T368 |
T369 |
det |
a,delay |
R88 |
T369 |
T366 |
conj |
delay,retardation |
R89 |
T370 |
T369 |
prep |
in,delay |
R90 |
T371 |
T372 |
amod |
terminal,differentiation |
R91 |
T372 |
T370 |
pobj |
differentiation,in |
R92 |
T373 |
T372 |
prep |
of,differentiation |
R93 |
T374 |
T375 |
det |
the,kidney |
R94 |
T375 |
T373 |
pobj |
kidney,of |
R95 |
T376 |
T375 |
punct |
", ",kidney |
R96 |
T377 |
T375 |
conj |
intestine,kidney |
R97 |
T378 |
T377 |
punct |
", ",intestine |
R98 |
T379 |
T377 |
conj |
liver,intestine |
R99 |
T380 |
T379 |
cc |
and,liver |