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PMC:549712 / 47961-49009 JSONTXT 4 Projects

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Id Subject Object Predicate Lexical cue
T14088 0-3 PRP$ denotes Our
T14089 4-11 NNS denotes results
T14090 12-23 VBP denotes demonstrate
T14091 24-28 IN denotes that
T14093 29-34 NN denotes Ptdsr
T14092 35-37 VBZ denotes is
T14094 38-47 JJ denotes essential
T14095 48-51 IN denotes for
T14096 52-55 DT denotes the
T14097 56-71 NN denotes differentiation
T14098 72-75 CC denotes and
T14099 76-86 NN denotes maturation
T14100 87-89 IN denotes of
T14101 90-98 JJ denotes multiple
T14102 99-106 NNS denotes tissues
T14103 107-113 IN denotes during
T14104 114-127 NN denotes embryogenesis
T14105 127-128 . denotes .
T14106 128-244 sentence denotes Ablation of Ptdsr function results in neonatal lethality and severe defects in the morphogenesis of several organs.
T14107 129-137 NN denotes Ablation
T14109 138-140 IN denotes of
T14110 141-146 NN denotes Ptdsr
T14111 147-155 NN denotes function
T14108 156-163 VBZ denotes results
T14112 164-166 IN denotes in
T14113 167-175 JJ denotes neonatal
T14114 176-185 NN denotes lethality
T14115 186-189 CC denotes and
T14116 190-196 JJ denotes severe
T14117 197-204 NNS denotes defects
T14118 205-207 IN denotes in
T14119 208-211 DT denotes the
T14120 212-225 NN denotes morphogenesis
T14121 226-228 IN denotes of
T14122 229-236 JJ denotes several
T14123 237-243 NNS denotes organs
T14124 243-244 . denotes .
T14125 244-398 sentence denotes The developmental malformations cannot be explained by impaired clearance of apoptotic cells, a process that proved to be normal in Ptdsr-deficient mice.
T14126 245-248 DT denotes The
T14128 249-262 JJ denotes developmental
T14127 263-276 NNS denotes malformations
T14130 277-280 MD denotes can
T14131 280-283 RB denotes not
T14132 284-286 VB denotes be
T14129 287-296 VBN denotes explained
T14133 297-299 IN denotes by
T14134 300-308 JJ denotes impaired
T14135 309-318 NN denotes clearance
T14136 319-321 IN denotes of
T14137 322-331 JJ denotes apoptotic
T14138 332-337 NNS denotes cells
T14139 337-339 , denotes ,
T14140 339-340 DT denotes a
T14141 341-348 NN denotes process
T14142 349-353 WDT denotes that
T14143 354-360 VBD denotes proved
T14144 361-363 TO denotes to
T14145 364-366 VB denotes be
T14146 367-373 JJ denotes normal
T14147 374-376 IN denotes in
T14148 377-382 NN denotes Ptdsr
T14150 382-383 HYPH denotes -
T14149 383-392 JJ denotes deficient
T14151 393-397 NNS denotes mice
T14152 397-398 . denotes .
T14153 398-762 sentence denotes This opens up the possibility either that there is an as-yet unknown Ptdsr receptor, which might act as a primary phosphatidylserine recognition receptor, or that recognition of phosphatidylserine and subsequent apoptotic cell engulfment and anti-inflammatory signaling are mainly mediated through phosphatidylserine bridging proteins and their cognate receptors.
T14154 399-403 DT denotes This
T14155 404-409 VBZ denotes opens
T14156 410-412 RP denotes up
T14157 413-416 DT denotes the
T14158 417-428 NN denotes possibility
T14159 429-435 CC denotes either
T14161 436-440 IN denotes that
T14162 441-446 EX denotes there
T14160 447-449 VBZ denotes is
T14163 450-452 DT denotes an
T14165 453-455 RB denotes as
T14167 455-456 HYPH denotes -
T14166 456-459 RB denotes yet
T14168 460-467 JJ denotes unknown
T14169 468-473 NN denotes Ptdsr
T14164 474-482 NN denotes receptor
T14170 482-484 , denotes ,
T14171 484-489 WDT denotes which
T14173 490-495 MD denotes might
T14172 496-499 VB denotes act
T14174 500-502 IN denotes as
T14175 503-504 DT denotes a
T14177 505-512 JJ denotes primary
T14178 513-531 NN denotes phosphatidylserine
T14179 532-543 NN denotes recognition
T14176 544-552 NN denotes receptor
T14180 552-554 , denotes ,
T14181 554-556 CC denotes or
T14182 557-561 IN denotes that
T14184 562-573 NN denotes recognition
T14185 574-576 IN denotes of
T14186 577-595 NN denotes phosphatidylserine
T14187 596-599 CC denotes and
T14188 600-610 JJ denotes subsequent
T14190 611-620 JJ denotes apoptotic
T14191 621-625 NN denotes cell
T14189 626-636 NN denotes engulfment
T14192 637-640 CC denotes and
T14193 641-658 JJ denotes anti-inflammatory
T14194 659-668 NN denotes signaling
T14195 669-672 VBP denotes are
T14196 673-679 RB denotes mainly
T14183 680-688 VBN denotes mediated
T14197 689-696 IN denotes through
T14198 697-715 NN denotes phosphatidylserine
T14200 716-724 NN denotes bridging
T14199 725-733 NN denotes proteins
T14201 734-737 CC denotes and
T14202 738-743 PRP$ denotes their
T14204 744-751 JJ denotes cognate
T14203 752-761 NNS denotes receptors
T14205 761-762 . denotes .
T14206 762-918 sentence denotes Although Ptdsr -/- macrophages were not impaired in their ability to phagocytose apoptotic cells, they showed reduced cytokine responses after stimulation.
T14207 763-771 IN denotes Although
T14209 772-777 NN denotes Ptdsr
T14211 778-779 SYM denotes -
T14212 779-780 HYPH denotes /
T14213 780-781 SYM denotes -
T14210 782-793 NNS denotes macrophages
T14214 794-798 VBD denotes were
T14215 799-802 RB denotes not
T14208 803-811 VBN denotes impaired
T14217 812-814 IN denotes in
T14218 815-820 PRP$ denotes their
T14219 821-828 NN denotes ability
T14220 829-831 TO denotes to
T14221 832-843 VB denotes phagocytose
T14222 844-853 JJ denotes apoptotic
T14223 854-859 NNS denotes cells
T14224 859-861 , denotes ,
T14225 861-865 PRP denotes they
T14216 866-872 VBD denotes showed
T14226 873-880 VBN denotes reduced
T14228 881-889 NN denotes cytokine
T14227 890-899 NNS denotes responses
T14229 900-905 IN denotes after
T14230 906-917 NN denotes stimulation
T14231 917-918 . denotes .
T14232 918-1048 sentence denotes Further work will be required to determine the molecular mechanisms of these newly recognized Ptdsr functions during development.
T14233 919-926 JJ denotes Further
T14234 927-931 NN denotes work
T14236 932-936 MD denotes will
T14237 937-939 VB denotes be
T14235 940-948 VBN denotes required
T14238 949-951 TO denotes to
T14239 952-961 VB denotes determine
T14240 962-965 DT denotes the
T14242 966-975 JJ denotes molecular
T14241 976-986 NNS denotes mechanisms
T14243 987-989 IN denotes of
T14244 990-995 DT denotes these
T14246 996-1001 RB denotes newly
T14247 1002-1012 VBN denotes recognized
T14248 1013-1018 NN denotes Ptdsr
T14245 1019-1028 NNS denotes functions
T14249 1029-1035 IN denotes during
T14250 1036-1047 NN denotes development
T14251 1047-1048 . denotes .
R8462 T14088 T14089 poss Our,results
R8463 T14089 T14090 nsubj results,demonstrate
R8464 T14091 T14092 mark that,is
R8465 T14092 T14090 ccomp is,demonstrate
R8466 T14093 T14092 nsubj Ptdsr,is
R8467 T14094 T14092 acomp essential,is
R8468 T14095 T14094 prep for,essential
R8469 T14096 T14097 det the,differentiation
R8470 T14097 T14095 pobj differentiation,for
R8471 T14098 T14097 cc and,differentiation
R8472 T14099 T14097 conj maturation,differentiation
R8473 T14100 T14097 prep of,differentiation
R8474 T14101 T14102 amod multiple,tissues
R8475 T14102 T14100 pobj tissues,of
R8476 T14103 T14092 prep during,is
R8477 T14104 T14103 pobj embryogenesis,during
R8478 T14105 T14090 punct .,demonstrate
R8479 T14107 T14108 nsubj Ablation,results
R8480 T14109 T14107 prep of,Ablation
R8481 T14110 T14111 compound Ptdsr,function
R8482 T14111 T14109 pobj function,of
R8483 T14112 T14108 prep in,results
R8484 T14113 T14114 amod neonatal,lethality
R8485 T14114 T14112 pobj lethality,in
R8486 T14115 T14114 cc and,lethality
R8487 T14116 T14117 amod severe,defects
R8488 T14117 T14114 conj defects,lethality
R8489 T14118 T14117 prep in,defects
R8490 T14119 T14120 det the,morphogenesis
R8491 T14120 T14118 pobj morphogenesis,in
R8492 T14121 T14120 prep of,morphogenesis
R8493 T14122 T14123 amod several,organs
R8494 T14123 T14121 pobj organs,of
R8495 T14124 T14108 punct .,results
R8496 T14126 T14127 det The,malformations
R8497 T14127 T14129 nsubjpass malformations,explained
R8498 T14128 T14127 amod developmental,malformations
R8499 T14130 T14129 aux can,explained
R8500 T14131 T14129 neg not,explained
R8501 T14132 T14129 auxpass be,explained
R8502 T14133 T14129 agent by,explained
R8503 T14134 T14135 amod impaired,clearance
R8504 T14135 T14133 pobj clearance,by
R8505 T14136 T14135 prep of,clearance
R8506 T14137 T14138 amod apoptotic,cells
R8507 T14138 T14136 pobj cells,of
R8508 T14139 T14135 punct ", ",clearance
R8509 T14140 T14141 det a,process
R8510 T14141 T14135 appos process,clearance
R8511 T14142 T14143 dep that,proved
R8512 T14143 T14141 relcl proved,process
R8513 T14144 T14145 aux to,be
R8514 T14145 T14143 xcomp be,proved
R8515 T14146 T14145 acomp normal,be
R8516 T14147 T14145 prep in,be
R8517 T14148 T14149 npadvmod Ptdsr,deficient
R8518 T14149 T14151 amod deficient,mice
R8519 T14150 T14149 punct -,deficient
R8520 T14151 T14147 pobj mice,in
R8521 T14152 T14129 punct .,explained
R8522 T14154 T14155 nsubj This,opens
R8523 T14156 T14155 prt up,opens
R8524 T14157 T14158 det the,possibility
R8525 T14158 T14155 dobj possibility,opens
R8526 T14159 T14160 preconj either,is
R8527 T14160 T14158 advcl is,possibility
R8528 T14161 T14160 mark that,is
R8529 T14162 T14160 expl there,is
R8530 T14163 T14164 det an,receptor
R8531 T14164 T14160 attr receptor,is
R8532 T14165 T14166 advmod as,yet
R8533 T14166 T14168 advmod yet,unknown
R8534 T14167 T14166 punct -,yet
R8535 T14168 T14164 amod unknown,receptor
R8536 T14169 T14164 compound Ptdsr,receptor
R8537 T14170 T14164 punct ", ",receptor
R8538 T14171 T14172 dep which,act
R8539 T14172 T14164 relcl act,receptor
R8540 T14173 T14172 aux might,act
R8541 T14174 T14172 prep as,act
R8542 T14175 T14176 det a,receptor
R8543 T14176 T14174 pobj receptor,as
R8544 T14177 T14176 amod primary,receptor
R8545 T14178 T14176 compound phosphatidylserine,receptor
R8546 T14179 T14176 compound recognition,receptor
R8547 T14180 T14160 punct ", ",is
R8548 T14181 T14160 cc or,is
R8549 T14182 T14183 mark that,mediated
R8550 T14183 T14160 conj mediated,is
R8551 T14184 T14183 nsubjpass recognition,mediated
R8552 T14185 T14184 prep of,recognition
R8553 T14186 T14185 pobj phosphatidylserine,of
R8554 T14187 T14184 cc and,recognition
R8555 T14188 T14189 amod subsequent,engulfment
R8556 T14189 T14184 conj engulfment,recognition
R8557 T14190 T14189 amod apoptotic,engulfment
R8558 T14191 T14189 compound cell,engulfment
R8559 T14192 T14189 cc and,engulfment
R8560 T14193 T14194 amod anti-inflammatory,signaling
R8561 T14194 T14189 conj signaling,engulfment
R8562 T14195 T14183 auxpass are,mediated
R8563 T14196 T14183 advmod mainly,mediated
R8564 T14197 T14183 prep through,mediated
R8565 T14198 T14199 compound phosphatidylserine,proteins
R8566 T14199 T14197 pobj proteins,through
R8567 T14200 T14199 compound bridging,proteins
R8568 T14201 T14199 cc and,proteins
R8569 T14202 T14203 poss their,receptors
R8570 T14203 T14199 conj receptors,proteins
R8571 T14204 T14203 amod cognate,receptors
R8572 T14205 T14155 punct .,opens
R8573 T14207 T14208 mark Although,impaired
R8574 T14208 T14216 advcl impaired,showed
R8575 T14209 T14210 nmod Ptdsr,macrophages
R8576 T14210 T14208 nsubjpass macrophages,impaired
R8577 T14211 T14209 punct -,Ptdsr
R8578 T14212 T14209 punct /,Ptdsr
R8579 T14213 T14209 punct -,Ptdsr
R8580 T14214 T14208 auxpass were,impaired
R8581 T14215 T14208 neg not,impaired
R8582 T14217 T14208 prep in,impaired
R8583 T14218 T14219 poss their,ability
R8584 T14219 T14217 pobj ability,in
R8585 T14220 T14221 aux to,phagocytose
R8586 T14221 T14219 acl phagocytose,ability
R8587 T14222 T14223 amod apoptotic,cells
R8588 T14223 T14221 dobj cells,phagocytose
R8589 T14224 T14216 punct ", ",showed
R8590 T14225 T14216 nsubj they,showed
R8591 T14226 T14227 amod reduced,responses
R8592 T14227 T14216 dobj responses,showed
R8593 T14228 T14227 compound cytokine,responses
R8594 T14229 T14216 prep after,showed
R8595 T14230 T14229 pobj stimulation,after
R8596 T14231 T14216 punct .,showed
R8597 T14233 T14234 amod Further,work
R8598 T14234 T14235 nsubjpass work,required
R8599 T14236 T14235 aux will,required
R8600 T14237 T14235 auxpass be,required
R8601 T14238 T14239 aux to,determine
R8602 T14239 T14235 advcl determine,required
R8603 T14240 T14241 det the,mechanisms
R8604 T14241 T14239 dobj mechanisms,determine
R8605 T14242 T14241 amod molecular,mechanisms
R8606 T14243 T14241 prep of,mechanisms
R8607 T14244 T14245 det these,functions
R8608 T14245 T14243 pobj functions,of
R8609 T14246 T14247 advmod newly,recognized
R8610 T14247 T14245 amod recognized,functions
R8611 T14248 T14245 compound Ptdsr,functions
R8612 T14249 T14241 prep during,mechanisms
R8613 T14250 T14249 pobj development,during
R8614 T14251 T14235 punct .,required