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PMC:549712 / 31062-32440 JSONTXT 5 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T10059 0-2 IN denotes In
T10061 3-6 DT denotes the
T10063 7-12 NN denotes Ptdsr
T10065 12-13 HYPH denotes -
T10064 13-21 NN denotes knockout
T10066 22-27 NN denotes mouse
T10062 28-32 NN denotes line
T10067 33-41 VBN denotes reported
T10068 42-46 RB denotes here
T10069 46-48 , denotes ,
T10070 48-54 NN denotes growth
T10071 55-66 NN denotes retardation
T10060 67-74 VBD denotes started
T10072 75-79 IN denotes from
T10073 80-85 NN denotes E12.5
T10074 86-93 RB denotes onwards
T10075 94-97 CC denotes and
T10076 98-101 VBD denotes was
T10077 102-112 VBN denotes associated
T10078 113-117 IN denotes with
T10079 118-125 VBN denotes delayed
T10080 126-141 NN denotes differentiation
T10081 142-144 IN denotes in
T10082 145-152 JJ denotes several
T10083 153-159 NNS denotes organs
T10084 160-162 IN denotes in
T10086 163-168 WDT denotes which
T10087 169-174 NN denotes Ptdsr
T10088 175-177 VBZ denotes is
T10085 178-187 VBN denotes expressed
T10089 188-194 CC denotes either
T10090 195-201 IN denotes during
T10091 202-215 NN denotes embryogenesis
T10092 216-218 CC denotes or
T10093 219-224 RB denotes later
T10094 225-227 IN denotes in
T10095 228-237 NN denotes adulthood
T10096 237-238 . denotes .
T10097 238-337 sentence denotes At E16.5 almost no branching morphogenesis of the lung epithelium was observed in Ptdsr -/- lungs.
T10098 239-241 IN denotes At
T10100 242-247 NN denotes E16.5
T10101 248-254 RB denotes almost
T10103 255-257 DT denotes no
T10104 258-267 NN denotes branching
T10102 268-281 NN denotes morphogenesis
T10105 282-284 IN denotes of
T10106 285-288 DT denotes the
T10108 289-293 NN denotes lung
T10107 294-304 NN denotes epithelium
T10109 305-308 VBD denotes was
T10099 309-317 VBN denotes observed
T10110 318-320 IN denotes in
T10111 321-326 NN denotes Ptdsr
T10113 327-328 SYM denotes -
T10114 328-329 HYPH denotes /
T10115 329-330 SYM denotes -
T10112 331-336 NNS denotes lungs
T10116 336-337 . denotes .
T10117 337-552 sentence denotes Similarly, epithelial structures were only partially developed in mutant kidneys, without terminal differentiation of Bowman's capsule and with a severe reduction in the number of differentiated collecting tubules.
T10118 338-347 RB denotes Similarly
T10120 347-349 , denotes ,
T10121 349-359 JJ denotes epithelial
T10122 360-370 NNS denotes structures
T10123 371-375 VBD denotes were
T10124 376-380 RB denotes only
T10125 381-390 RB denotes partially
T10119 391-400 VBN denotes developed
T10126 401-403 IN denotes in
T10127 404-410 JJ denotes mutant
T10128 411-418 NNS denotes kidneys
T10129 418-420 , denotes ,
T10130 420-427 IN denotes without
T10131 428-436 JJ denotes terminal
T10132 437-452 NN denotes differentiation
T10133 453-455 IN denotes of
T10134 456-462 NNP denotes Bowman
T10136 462-464 POS denotes 's
T10135 465-472 NN denotes capsule
T10137 473-476 CC denotes and
T10138 477-481 IN denotes with
T10139 482-483 DT denotes a
T10141 484-490 JJ denotes severe
T10140 491-500 NN denotes reduction
T10142 501-503 IN denotes in
T10143 504-507 DT denotes the
T10144 508-514 NN denotes number
T10145 515-517 IN denotes of
T10146 518-532 VBN denotes differentiated
T10148 533-543 NN denotes collecting
T10147 544-551 NNS denotes tubules
T10149 551-552 . denotes .
T10150 552-654 sentence denotes Likewise, the differentiation of the intestine was also severely delayed at this developmental stage.
T10151 553-561 RB denotes Likewise
T10153 561-563 , denotes ,
T10154 563-566 DT denotes the
T10155 567-582 NN denotes differentiation
T10156 583-585 IN denotes of
T10157 586-589 DT denotes the
T10158 590-599 NN denotes intestine
T10159 600-603 VBD denotes was
T10160 604-608 RB denotes also
T10161 609-617 RB denotes severely
T10152 618-625 VBN denotes delayed
T10162 626-628 IN denotes at
T10163 629-633 DT denotes this
T10165 634-647 JJ denotes developmental
T10164 648-653 NN denotes stage
T10166 653-654 . denotes .
T10167 654-837 sentence denotes When compared with wild-type controls, intestinal tissues of Ptdsr knockout mice appeared unstructured, with an absence of enteric ganglia and of differentiated smooth muscle tissue.
T10168 655-659 WRB denotes When
T10169 660-668 VBN denotes compared
T10171 669-673 IN denotes with
T10172 674-678 JJ denotes wild
T10174 678-679 HYPH denotes -
T10173 679-683 NN denotes type
T10175 684-692 NNS denotes controls
T10176 692-694 , denotes ,
T10177 694-704 JJ denotes intestinal
T10178 705-712 NNS denotes tissues
T10179 713-715 IN denotes of
T10180 716-721 NN denotes Ptdsr
T10182 722-730 NN denotes knockout
T10181 731-735 NNS denotes mice
T10170 736-744 VBD denotes appeared
T10183 745-757 JJ denotes unstructured
T10184 757-759 , denotes ,
T10185 759-763 IN denotes with
T10186 764-766 DT denotes an
T10187 767-774 NN denotes absence
T10188 775-777 IN denotes of
T10189 778-785 JJ denotes enteric
T10190 786-793 NNS denotes ganglia
T10191 794-797 CC denotes and
T10192 798-800 IN denotes of
T10193 801-815 VBN denotes differentiated
T10195 816-822 JJ denotes smooth
T10196 823-829 NN denotes muscle
T10194 830-836 NN denotes tissue
T10197 836-837 . denotes .
T10198 837-996 sentence denotes Interestingly, defects in kidney and intestine differentiation were not described in the Ptdsr-knockouts generated by Li et al. [31] and Kunisaki et al. [32].
T10199 838-851 RB denotes Interestingly
T10201 851-853 , denotes ,
T10202 853-860 NNS denotes defects
T10203 861-863 IN denotes in
T10204 864-870 NN denotes kidney
T10206 871-874 CC denotes and
T10207 875-884 NN denotes intestine
T10205 885-900 NN denotes differentiation
T10208 901-905 VBD denotes were
T10209 906-909 RB denotes not
T10200 910-919 VBN denotes described
T10210 920-922 IN denotes in
T10211 923-926 DT denotes the
T10213 927-932 NN denotes Ptdsr
T10214 932-933 HYPH denotes -
T10212 933-942 NNS denotes knockouts
T10215 943-952 VBN denotes generated
T10216 953-955 IN denotes by
T10217 956-958 NNP denotes Li
T10218 959-961 FW denotes et
T10219 962-965 FW denotes al.
T10220 966-967 -LRB- denotes [
T10221 967-969 CD denotes 31
T10222 969-970 -RRB- denotes ]
T10223 971-974 CC denotes and
T10224 975-983 NNP denotes Kunisaki
T10225 984-986 FW denotes et
T10226 987-990 FW denotes al.
T10227 991-992 -LRB- denotes [
T10228 992-994 CD denotes 32
T10229 994-995 -RRB- denotes ]
T10230 995-996 . denotes .
T10231 996-1190 sentence denotes Surprisingly, when we examined Ptdsr-/- embryos shortly before birth (E18.5) or neonatally, we found only mild differentiation delays in organs that appeared severely affected at mid-gestation.
T10232 997-1009 RB denotes Surprisingly
T10234 1009-1011 , denotes ,
T10235 1011-1015 WRB denotes when
T10237 1016-1018 PRP denotes we
T10236 1019-1027 VBD denotes examined
T10238 1028-1033 NN denotes Ptdsr
T10240 1033-1034 SYM denotes -
T10241 1034-1035 HYPH denotes /
T10242 1035-1036 SYM denotes -
T10239 1037-1044 NNS denotes embryos
T10243 1045-1052 RB denotes shortly
T10244 1053-1059 IN denotes before
T10245 1060-1065 NN denotes birth
T10246 1066-1067 -LRB- denotes (
T10247 1067-1072 NN denotes E18.5
T10248 1072-1073 -RRB- denotes )
T10249 1074-1076 CC denotes or
T10250 1077-1087 RB denotes neonatally
T10251 1087-1089 , denotes ,
T10252 1089-1091 PRP denotes we
T10233 1092-1097 VBD denotes found
T10253 1098-1102 RB denotes only
T10254 1103-1107 JJ denotes mild
T10256 1108-1123 NN denotes differentiation
T10255 1124-1130 NNS denotes delays
T10257 1131-1133 IN denotes in
T10258 1134-1140 NNS denotes organs
T10259 1141-1145 WDT denotes that
T10260 1146-1154 VBD denotes appeared
T10261 1155-1163 RB denotes severely
T10262 1164-1172 JJ denotes affected
T10263 1173-1175 IN denotes at
T10264 1176-1189 NN denotes mid-gestation
T10265 1189-1190 . denotes .
T10266 1190-1378 sentence denotes This 'recovery' was most visible in Ptdsr -/- lungs: at P0 we found expanded lungs in the knockout mice that showed normal branching patterns, with differentiated alveoli and bronchioles.
T10267 1191-1195 DT denotes This
T10269 1196-1197 `` denotes '
T10268 1197-1205 NN denotes recovery
T10271 1205-1206 '' denotes '
T10270 1207-1210 VBD denotes was
T10273 1211-1215 RBS denotes most
T10274 1216-1223 JJ denotes visible
T10275 1224-1226 IN denotes in
T10276 1227-1232 NN denotes Ptdsr
T10278 1233-1234 SYM denotes -
T10279 1234-1235 HYPH denotes /
T10280 1235-1236 SYM denotes -
T10277 1237-1242 NNS denotes lungs
T10281 1242-1244 : denotes :
T10282 1244-1246 IN denotes at
T10283 1247-1249 NN denotes P0
T10284 1250-1252 PRP denotes we
T10272 1253-1258 VBD denotes found
T10285 1259-1267 VBN denotes expanded
T10286 1268-1273 NNS denotes lungs
T10287 1274-1276 IN denotes in
T10288 1277-1280 DT denotes the
T10290 1281-1289 NN denotes knockout
T10289 1290-1294 NNS denotes mice
T10291 1295-1299 WDT denotes that
T10292 1300-1306 VBD denotes showed
T10293 1307-1313 JJ denotes normal
T10295 1314-1323 NN denotes branching
T10294 1324-1332 NNS denotes patterns
T10296 1332-1334 , denotes ,
T10297 1334-1338 IN denotes with
T10298 1339-1353 VBN denotes differentiated
T10299 1354-1361 NNS denotes alveoli
T10300 1362-1365 CC denotes and
T10301 1366-1377 NNS denotes bronchioles
T10302 1377-1378 . denotes .
R5542 T10059 T10060 prep In,started
R5543 T10061 T10062 det the,line
R5544 T10062 T10059 pobj line,In
R5545 T10063 T10064 compound Ptdsr,knockout
R5546 T10064 T10062 compound knockout,line
R5547 T10065 T10064 punct -,knockout
R5548 T10066 T10062 compound mouse,line
R5549 T10067 T10062 acl reported,line
R5550 T10068 T10067 advmod here,reported
R5551 T10069 T10060 punct ", ",started
R5552 T10070 T10071 compound growth,retardation
R5553 T10071 T10060 nsubj retardation,started
R5554 T10072 T10060 prep from,started
R5555 T10073 T10072 pobj E12.5,from
R5556 T10074 T10073 advmod onwards,E12.5
R5557 T10075 T10060 cc and,started
R5558 T10076 T10077 auxpass was,associated
R5559 T10077 T10060 conj associated,started
R5560 T10078 T10077 prep with,associated
R5561 T10079 T10080 amod delayed,differentiation
R5562 T10080 T10078 pobj differentiation,with
R5563 T10081 T10080 prep in,differentiation
R5564 T10082 T10083 amod several,organs
R5565 T10083 T10081 pobj organs,in
R5566 T10084 T10085 prep in,expressed
R5567 T10085 T10083 relcl expressed,organs
R5568 T10086 T10084 pobj which,in
R5569 T10087 T10085 nsubjpass Ptdsr,expressed
R5570 T10088 T10085 auxpass is,expressed
R5571 T10089 T10090 preconj either,during
R5572 T10090 T10085 prep during,expressed
R5573 T10091 T10090 pobj embryogenesis,during
R5574 T10092 T10090 cc or,during
R5575 T10093 T10094 advmod later,in
R5576 T10094 T10090 conj in,during
R5577 T10095 T10094 pobj adulthood,in
R5578 T10096 T10060 punct .,started
R5579 T10098 T10099 prep At,observed
R5580 T10100 T10098 pobj E16.5,At
R5581 T10101 T10102 advmod almost,morphogenesis
R5582 T10102 T10099 nsubjpass morphogenesis,observed
R5583 T10103 T10102 det no,morphogenesis
R5584 T10104 T10102 compound branching,morphogenesis
R5585 T10105 T10102 prep of,morphogenesis
R5586 T10106 T10107 det the,epithelium
R5587 T10107 T10105 pobj epithelium,of
R5588 T10108 T10107 compound lung,epithelium
R5589 T10109 T10099 auxpass was,observed
R5590 T10110 T10099 prep in,observed
R5591 T10111 T10112 nmod Ptdsr,lungs
R5592 T10112 T10110 pobj lungs,in
R5593 T10113 T10111 punct -,Ptdsr
R5594 T10114 T10111 punct /,Ptdsr
R5595 T10115 T10111 punct -,Ptdsr
R5596 T10116 T10099 punct .,observed
R5597 T10118 T10119 advmod Similarly,developed
R5598 T10120 T10119 punct ", ",developed
R5599 T10121 T10122 amod epithelial,structures
R5600 T10122 T10119 nsubjpass structures,developed
R5601 T10123 T10119 auxpass were,developed
R5602 T10124 T10119 advmod only,developed
R5603 T10125 T10119 advmod partially,developed
R5604 T10126 T10119 prep in,developed
R5605 T10127 T10128 amod mutant,kidneys
R5606 T10128 T10126 pobj kidneys,in
R5607 T10129 T10119 punct ", ",developed
R5608 T10130 T10119 prep without,developed
R5609 T10131 T10132 amod terminal,differentiation
R5610 T10132 T10130 pobj differentiation,without
R5611 T10133 T10132 prep of,differentiation
R5612 T10134 T10135 poss Bowman,capsule
R5613 T10135 T10133 pobj capsule,of
R5614 T10136 T10134 case 's,Bowman
R5615 T10137 T10130 cc and,without
R5616 T10138 T10130 conj with,without
R5617 T10139 T10140 det a,reduction
R5618 T10140 T10138 pobj reduction,with
R5619 T10141 T10140 amod severe,reduction
R5620 T10142 T10140 prep in,reduction
R5621 T10143 T10144 det the,number
R5622 T10144 T10142 pobj number,in
R5623 T10145 T10144 prep of,number
R5624 T10146 T10147 amod differentiated,tubules
R5625 T10147 T10145 pobj tubules,of
R5626 T10148 T10147 compound collecting,tubules
R5627 T10149 T10119 punct .,developed
R5628 T10151 T10152 advmod Likewise,delayed
R5629 T10153 T10152 punct ", ",delayed
R5630 T10154 T10155 det the,differentiation
R5631 T10155 T10152 nsubjpass differentiation,delayed
R5632 T10156 T10155 prep of,differentiation
R5633 T10157 T10158 det the,intestine
R5634 T10158 T10156 pobj intestine,of
R5635 T10159 T10152 auxpass was,delayed
R5636 T10160 T10152 advmod also,delayed
R5637 T10161 T10152 advmod severely,delayed
R5638 T10162 T10152 prep at,delayed
R5639 T10163 T10164 det this,stage
R5640 T10164 T10162 pobj stage,at
R5641 T10165 T10164 amod developmental,stage
R5642 T10166 T10152 punct .,delayed
R5643 T10168 T10169 advmod When,compared
R5644 T10169 T10170 advcl compared,appeared
R5645 T10171 T10169 prep with,compared
R5646 T10172 T10173 amod wild,type
R5647 T10173 T10175 compound type,controls
R5648 T10174 T10173 punct -,type
R5649 T10175 T10171 pobj controls,with
R5650 T10176 T10170 punct ", ",appeared
R5651 T10177 T10178 amod intestinal,tissues
R5652 T10178 T10170 nsubj tissues,appeared
R5653 T10179 T10178 prep of,tissues
R5654 T10180 T10181 compound Ptdsr,mice
R5655 T10181 T10179 pobj mice,of
R5656 T10182 T10181 compound knockout,mice
R5657 T10183 T10170 oprd unstructured,appeared
R5658 T10184 T10170 punct ", ",appeared
R5659 T10185 T10170 prep with,appeared
R5660 T10186 T10187 det an,absence
R5661 T10187 T10185 pobj absence,with
R5662 T10188 T10187 prep of,absence
R5663 T10189 T10190 amod enteric,ganglia
R5664 T10190 T10188 pobj ganglia,of
R5665 T10191 T10188 cc and,of
R5666 T10192 T10188 conj of,of
R5667 T10193 T10194 amod differentiated,tissue
R5668 T10194 T10192 pobj tissue,of
R5669 T10195 T10196 amod smooth,muscle
R5670 T10196 T10194 compound muscle,tissue
R5671 T10197 T10170 punct .,appeared
R5672 T10199 T10200 advmod Interestingly,described
R5673 T10201 T10200 punct ", ",described
R5674 T10202 T10200 nsubjpass defects,described
R5675 T10203 T10202 prep in,defects
R5676 T10204 T10205 nmod kidney,differentiation
R5677 T10205 T10203 pobj differentiation,in
R5678 T10206 T10204 cc and,kidney
R5679 T10207 T10204 conj intestine,kidney
R5680 T10208 T10200 auxpass were,described
R5681 T10209 T10200 neg not,described
R5682 T10210 T10200 prep in,described
R5683 T10211 T10212 det the,knockouts
R5684 T10212 T10210 pobj knockouts,in
R5685 T10213 T10212 compound Ptdsr,knockouts
R5686 T10214 T10212 punct -,knockouts
R5687 T10215 T10212 acl generated,knockouts
R5688 T10216 T10215 agent by,generated
R5689 T10217 T10216 pobj Li,by
R5690 T10218 T10219 advmod et,al.
R5691 T10219 T10217 advmod al.,Li
R5692 T10220 T10221 punct [,31
R5693 T10221 T10217 parataxis 31,Li
R5694 T10222 T10221 punct ],31
R5695 T10223 T10217 cc and,Li
R5696 T10224 T10217 conj Kunisaki,Li
R5697 T10225 T10226 advmod et,al.
R5698 T10226 T10224 advmod al.,Kunisaki
R5699 T10227 T10228 punct [,32
R5700 T10228 T10224 parataxis 32,Kunisaki
R5701 T10229 T10228 punct ],32
R5702 T10230 T10200 punct .,described
R5703 T10232 T10233 advmod Surprisingly,found
R5704 T10234 T10233 punct ", ",found
R5705 T10235 T10236 advmod when,examined
R5706 T10236 T10233 advcl examined,found
R5707 T10237 T10236 nsubj we,examined
R5708 T10238 T10239 nmod Ptdsr,embryos
R5709 T10239 T10236 dobj embryos,examined
R5710 T10240 T10238 punct -,Ptdsr
R5711 T10241 T10238 punct /,Ptdsr
R5712 T10242 T10238 punct -,Ptdsr
R5713 T10243 T10244 advmod shortly,before
R5714 T10244 T10236 prep before,examined
R5715 T10245 T10244 pobj birth,before
R5716 T10246 T10247 punct (,E18.5
R5717 T10247 T10245 parataxis E18.5,birth
R5718 T10248 T10247 punct ),E18.5
R5719 T10249 T10244 cc or,before
R5720 T10250 T10244 conj neonatally,before
R5721 T10251 T10233 punct ", ",found
R5722 T10252 T10233 nsubj we,found
R5723 T10253 T10233 advmod only,found
R5724 T10254 T10255 amod mild,delays
R5725 T10255 T10233 dobj delays,found
R5726 T10256 T10255 compound differentiation,delays
R5727 T10257 T10233 prep in,found
R5728 T10258 T10257 pobj organs,in
R5729 T10259 T10260 dep that,appeared
R5730 T10260 T10258 relcl appeared,organs
R5731 T10261 T10262 advmod severely,affected
R5732 T10262 T10260 oprd affected,appeared
R5733 T10263 T10260 prep at,appeared
R5734 T10264 T10263 pobj mid-gestation,at
R5735 T10265 T10233 punct .,found
R5736 T10267 T10268 det This,recovery
R5737 T10268 T10270 nsubj recovery,was
R5738 T10269 T10268 punct ',recovery
R5739 T10270 T10272 ccomp was,found
R5740 T10271 T10270 punct ',was
R5741 T10273 T10274 advmod most,visible
R5742 T10274 T10270 acomp visible,was
R5743 T10275 T10270 prep in,was
R5744 T10276 T10277 nmod Ptdsr,lungs
R5745 T10277 T10275 pobj lungs,in
R5746 T10278 T10276 punct -,Ptdsr
R5747 T10279 T10276 punct /,Ptdsr
R5748 T10280 T10276 punct -,Ptdsr
R5749 T10281 T10272 punct : ,found
R5750 T10282 T10272 prep at,found
R5751 T10283 T10282 pobj P0,at
R5752 T10284 T10272 nsubj we,found
R5753 T10285 T10286 amod expanded,lungs
R5754 T10286 T10272 dobj lungs,found
R5755 T10287 T10286 prep in,lungs
R5756 T10288 T10289 det the,mice
R5757 T10289 T10287 pobj mice,in
R5758 T10290 T10289 compound knockout,mice
R5759 T10291 T10292 dep that,showed
R5760 T10292 T10286 relcl showed,lungs
R5761 T10293 T10294 amod normal,patterns
R5762 T10294 T10292 dobj patterns,showed
R5763 T10295 T10294 compound branching,patterns
R5764 T10296 T10294 punct ", ",patterns
R5765 T10297 T10294 prep with,patterns
R5766 T10298 T10299 amod differentiated,alveoli
R5767 T10299 T10297 pobj alveoli,with
R5768 T10300 T10299 cc and,alveoli
R5769 T10301 T10299 conj bronchioles,alveoli
R5770 T10302 T10272 punct .,found