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PMC:549712 / 20399-26718 JSONTXT 5 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T6746 0-12 NN denotes Phagocytosis
T6748 13-16 CC denotes and
T6749 17-26 NN denotes clearance
T6750 27-29 IN denotes of
T6751 30-39 JJ denotes apoptotic
T6752 40-45 NNS denotes cells
T6747 46-48 VBZ denotes is
T6753 49-55 JJ denotes normal
T6754 56-58 IN denotes in
T6755 59-64 NN denotes Ptdsr
T6757 64-65 HYPH denotes -
T6756 65-74 JJ denotes deficient
T6758 75-79 NNS denotes mice
T6759 79-171 sentence denotes We next tested whether Ptdsr is functionally required for the clearance of apoptotic cells.
T6760 80-82 PRP denotes We
T6762 83-87 RB denotes next
T6761 88-94 VBD denotes tested
T6763 95-102 IN denotes whether
T6765 103-108 NN denotes Ptdsr
T6766 109-111 VBZ denotes is
T6767 112-124 RB denotes functionally
T6764 125-133 VBN denotes required
T6768 134-137 IN denotes for
T6769 138-141 DT denotes the
T6770 142-151 NN denotes clearance
T6771 152-154 IN denotes of
T6772 155-164 JJ denotes apoptotic
T6773 165-170 NNS denotes cells
T6774 170-171 . denotes .
T6775 171-277 sentence denotes We started with an investigation of cell death in vivo in the interdigital areas of the developing limbs.
T6776 172-174 PRP denotes We
T6777 175-182 VBD denotes started
T6778 183-187 IN denotes with
T6779 188-190 DT denotes an
T6780 191-204 NN denotes investigation
T6781 205-207 IN denotes of
T6782 208-212 NN denotes cell
T6783 213-218 NN denotes death
T6784 219-221 FW denotes in
T6785 222-226 FW denotes vivo
T6786 227-229 IN denotes in
T6787 230-233 DT denotes the
T6789 234-246 JJ denotes interdigital
T6788 247-252 NNS denotes areas
T6790 253-255 IN denotes of
T6791 256-259 DT denotes the
T6793 260-270 VBG denotes developing
T6792 271-276 NNS denotes limbs
T6794 276-277 . denotes .
T6795 277-534 sentence denotes Apoptosis of interdigital cells in the distal mesenchyme of limb buds occurs most prominently from developmental stages E12.0 to E13.5 and can be easily examined in situ by whole-mount terminal deoxynucleotide transferase-mediated UTP end-labeling (TUNEL).
T6796 278-287 NN denotes Apoptosis
T6798 288-290 IN denotes of
T6799 291-303 JJ denotes interdigital
T6800 304-309 NNS denotes cells
T6801 310-312 IN denotes in
T6802 313-316 DT denotes the
T6804 317-323 JJ denotes distal
T6803 324-334 NN denotes mesenchyme
T6805 335-337 IN denotes of
T6806 338-342 NN denotes limb
T6807 343-347 NNS denotes buds
T6797 348-354 VBZ denotes occurs
T6808 355-359 RBS denotes most
T6809 360-371 RB denotes prominently
T6810 372-376 IN denotes from
T6811 377-390 JJ denotes developmental
T6813 391-397 NNS denotes stages
T6812 398-403 NN denotes E12.0
T6814 404-406 IN denotes to
T6815 407-412 NN denotes E13.5
T6816 413-416 CC denotes and
T6817 417-420 MD denotes can
T6819 421-423 VB denotes be
T6820 424-430 RB denotes easily
T6818 431-439 VBN denotes examined
T6821 440-442 FW denotes in
T6822 443-447 FW denotes situ
T6823 448-450 IN denotes by
T6824 451-456 JJ denotes whole
T6826 456-457 HYPH denotes -
T6825 457-462 NN denotes mount
T6828 463-471 JJ denotes terminal
T6829 472-487 NN denotes deoxynucleotide
T6830 488-499 NN denotes transferase
T6832 499-500 HYPH denotes -
T6831 500-508 VBN denotes mediated
T6833 509-512 NN denotes UTP
T6827 513-516 NN denotes end
T6834 516-517 HYPH denotes -
T6835 517-525 VBG denotes labeling
T6836 526-527 -LRB- denotes (
T6837 527-532 NN denotes TUNEL
T6838 532-533 -RRB- denotes )
T6839 533-534 . denotes .
T6840 534-682 sentence denotes We compared the pattern of interdigital cell death in fore and hind limb buds from Ptdsr -/- (n = 3) and Ptdsr +/+ (n = 3) mice at E12.5 and E13.5.
T6841 535-537 PRP denotes We
T6842 538-546 VBD denotes compared
T6843 547-550 DT denotes the
T6844 551-558 NN denotes pattern
T6845 559-561 IN denotes of
T6846 562-574 JJ denotes interdigital
T6848 575-579 NN denotes cell
T6847 580-585 NN denotes death
T6849 586-588 IN denotes in
T6850 589-593 JJ denotes fore
T6852 594-597 CC denotes and
T6853 598-602 JJ denotes hind
T6854 603-607 NN denotes limb
T6851 608-612 NNS denotes buds
T6855 613-617 IN denotes from
T6856 618-623 NN denotes Ptdsr
T6858 624-625 SYM denotes -
T6859 625-626 HYPH denotes /
T6860 626-627 SYM denotes -
T6861 628-629 -LRB- denotes (
T6863 629-630 NN denotes n
T6864 631-632 SYM denotes =
T6862 633-634 CD denotes 3
T6865 634-635 -RRB- denotes )
T6866 636-639 CC denotes and
T6867 640-645 NN denotes Ptdsr
T6868 646-647 SYM denotes +
T6869 647-648 HYPH denotes /
T6870 648-649 SYM denotes +
T6871 650-651 -LRB- denotes (
T6873 651-652 NN denotes n
T6874 653-654 SYM denotes =
T6872 655-656 CD denotes 3
T6875 656-657 -RRB- denotes )
T6857 658-662 NNS denotes mice
T6876 663-665 IN denotes at
T6877 666-671 NN denotes E12.5
T6878 672-675 CC denotes and
T6879 676-681 NN denotes E13.5
T6880 681-682 . denotes .
T6881 682-797 sentence denotes No differences in accumulation of TUNEL-positive cell corpses were observed between the two genotypes (Figure 6a).
T6882 683-685 DT denotes No
T6883 686-697 NNS denotes differences
T6885 698-700 IN denotes in
T6886 701-713 NN denotes accumulation
T6887 714-716 IN denotes of
T6888 717-722 NN denotes TUNEL
T6890 722-723 HYPH denotes -
T6889 723-731 JJ denotes positive
T6892 732-736 NN denotes cell
T6891 737-744 NNS denotes corpses
T6893 745-749 VBD denotes were
T6884 750-758 VBN denotes observed
T6894 759-766 IN denotes between
T6895 767-770 DT denotes the
T6897 771-774 CD denotes two
T6896 775-784 NNS denotes genotypes
T6898 785-786 -LRB- denotes (
T6900 786-792 NN denotes Figure
T6899 793-795 NN denotes 6a
T6901 795-796 -RRB- denotes )
T6902 796-797 . denotes .
T6903 797-1062 sentence denotes The kinetics of cell death occurrence and regression of the interdigital web was similar in wild-type and mutant littermates, providing no evidence that Ptdsr-deficiency is associated with impaired clearance of apoptotic interdigital cells during limb development.
T6904 798-801 DT denotes The
T6905 802-810 NN denotes kinetics
T6907 811-813 IN denotes of
T6908 814-818 NN denotes cell
T6909 819-824 NN denotes death
T6910 825-835 NN denotes occurrence
T6911 836-839 CC denotes and
T6912 840-850 NN denotes regression
T6913 851-853 IN denotes of
T6914 854-857 DT denotes the
T6916 858-870 JJ denotes interdigital
T6915 871-874 NN denotes web
T6906 875-878 VBD denotes was
T6917 879-886 JJ denotes similar
T6918 887-889 IN denotes in
T6919 890-894 JJ denotes wild
T6921 894-895 HYPH denotes -
T6920 895-899 NN denotes type
T6923 900-903 CC denotes and
T6924 904-910 JJ denotes mutant
T6922 911-922 NNS denotes littermates
T6925 922-924 , denotes ,
T6926 924-933 VBG denotes providing
T6927 934-936 DT denotes no
T6928 937-945 NN denotes evidence
T6929 946-950 IN denotes that
T6931 951-956 NN denotes Ptdsr
T6933 956-957 HYPH denotes -
T6932 957-967 NN denotes deficiency
T6934 968-970 VBZ denotes is
T6930 971-981 VBN denotes associated
T6935 982-986 IN denotes with
T6936 987-995 JJ denotes impaired
T6937 996-1005 NN denotes clearance
T6938 1006-1008 IN denotes of
T6939 1009-1018 JJ denotes apoptotic
T6941 1019-1031 JJ denotes interdigital
T6940 1032-1037 NNS denotes cells
T6942 1038-1044 IN denotes during
T6943 1045-1049 NN denotes limb
T6944 1050-1061 NN denotes development
T6945 1061-1062 . denotes .
T6946 1062-1338 sentence denotes To investigate further whether removal of apoptotic cells is impaired in Ptdsr -/- mice, we stained immunohistochemically for activated caspase 3 (aCasp3) and analyzed additional organs and tissues where apoptosis plays a crucial role in tissue remodeling during development.
T6947 1063-1065 TO denotes To
T6948 1066-1077 VB denotes investigate
T6950 1078-1085 RBR denotes further
T6951 1086-1093 IN denotes whether
T6953 1094-1101 NN denotes removal
T6954 1102-1104 IN denotes of
T6955 1105-1114 JJ denotes apoptotic
T6956 1115-1120 NNS denotes cells
T6957 1121-1123 VBZ denotes is
T6952 1124-1132 VBN denotes impaired
T6958 1133-1135 IN denotes in
T6959 1136-1141 NN denotes Ptdsr
T6961 1142-1143 SYM denotes -
T6962 1143-1144 HYPH denotes /
T6963 1144-1145 SYM denotes -
T6960 1146-1150 NNS denotes mice
T6964 1150-1152 , denotes ,
T6965 1152-1154 PRP denotes we
T6949 1155-1162 VBD denotes stained
T6966 1163-1184 RB denotes immunohistochemically
T6967 1185-1188 IN denotes for
T6968 1189-1198 VBN denotes activated
T6969 1199-1206 NN denotes caspase
T6970 1207-1208 CD denotes 3
T6971 1209-1210 -LRB- denotes (
T6972 1210-1216 NN denotes aCasp3
T6973 1216-1217 -RRB- denotes )
T6974 1218-1221 CC denotes and
T6975 1222-1230 VBN denotes analyzed
T6976 1231-1241 JJ denotes additional
T6977 1242-1248 NNS denotes organs
T6978 1249-1252 CC denotes and
T6979 1253-1260 NNS denotes tissues
T6980 1261-1266 WRB denotes where
T6982 1267-1276 NN denotes apoptosis
T6981 1277-1282 VBZ denotes plays
T6983 1283-1284 DT denotes a
T6985 1285-1292 JJ denotes crucial
T6984 1293-1297 NN denotes role
T6986 1298-1300 IN denotes in
T6987 1301-1307 NN denotes tissue
T6988 1308-1318 NN denotes remodeling
T6989 1319-1325 IN denotes during
T6990 1326-1337 NN denotes development
T6991 1337-1338 . denotes .
T6992 1338-1551 sentence denotes Starting at E12.5, we analyzed and compared the number and distribution of aCasp3-positive cells in over 140 serial sections of three wild-type and six Ptdsr -/- embryos in consecutive and corresponding sections.
T6993 1339-1347 VBG denotes Starting
T6995 1348-1350 IN denotes at
T6996 1351-1356 NN denotes E12.5
T6997 1356-1358 , denotes ,
T6998 1358-1360 PRP denotes we
T6994 1361-1369 VBD denotes analyzed
T6999 1370-1373 CC denotes and
T7000 1374-1382 VBD denotes compared
T7001 1383-1386 DT denotes the
T7002 1387-1393 NN denotes number
T7003 1394-1397 CC denotes and
T7004 1398-1410 NN denotes distribution
T7005 1411-1413 IN denotes of
T7006 1414-1420 NN denotes aCasp3
T7008 1420-1421 HYPH denotes -
T7007 1421-1429 JJ denotes positive
T7009 1430-1435 NNS denotes cells
T7010 1436-1438 IN denotes in
T7011 1439-1443 IN denotes over
T7012 1444-1447 CD denotes 140
T7014 1448-1454 JJ denotes serial
T7013 1455-1463 NNS denotes sections
T7015 1464-1466 IN denotes of
T7016 1467-1472 CD denotes three
T7018 1473-1477 JJ denotes wild
T7019 1477-1478 HYPH denotes -
T7017 1478-1482 NN denotes type
T7020 1483-1486 CC denotes and
T7021 1487-1490 CD denotes six
T7022 1491-1496 NN denotes Ptdsr
T7024 1497-1498 SYM denotes -
T7025 1498-1499 HYPH denotes /
T7026 1499-1500 SYM denotes -
T7023 1501-1508 NNS denotes embryos
T7027 1509-1511 IN denotes in
T7028 1512-1523 JJ denotes consecutive
T7030 1524-1527 CC denotes and
T7031 1528-1541 JJ denotes corresponding
T7029 1542-1550 NNS denotes sections
T7032 1550-1551 . denotes .
T7033 1551-1670 sentence denotes The sagittal sections were separated by 5 μm, allowing a detailed analysis of apoptosis in several organs and tissues.
T7034 1552-1555 DT denotes The
T7036 1556-1564 JJ denotes sagittal
T7035 1565-1573 NNS denotes sections
T7038 1574-1578 VBD denotes were
T7037 1579-1588 VBN denotes separated
T7039 1589-1591 IN denotes by
T7040 1592-1593 CD denotes 5
T7041 1594-1596 NNS denotes μm
T7042 1596-1598 , denotes ,
T7043 1598-1606 VBG denotes allowing
T7044 1607-1608 DT denotes a
T7046 1609-1617 JJ denotes detailed
T7045 1618-1626 NN denotes analysis
T7047 1627-1629 IN denotes of
T7048 1630-1639 NN denotes apoptosis
T7049 1640-1642 IN denotes in
T7050 1643-1650 JJ denotes several
T7051 1651-1657 NNS denotes organs
T7052 1658-1661 CC denotes and
T7053 1662-1669 NNS denotes tissues
T7054 1669-1670 . denotes .
T7055 1670-1894 sentence denotes Tissue restructuring by programmed cell death occurred most notably within the ventral part of the neural tube (Figure 6b,f) and in the developing paravertebral ganglia (Figure 6d,h) with many apoptotic cells being present.
T7056 1671-1677 NN denotes Tissue
T7057 1678-1691 NN denotes restructuring
T7059 1692-1694 IN denotes by
T7060 1695-1705 VBN denotes programmed
T7062 1706-1710 NN denotes cell
T7061 1711-1716 NN denotes death
T7058 1717-1725 VBD denotes occurred
T7063 1726-1730 RBS denotes most
T7064 1731-1738 RB denotes notably
T7065 1739-1745 IN denotes within
T7066 1746-1749 DT denotes the
T7068 1750-1757 JJ denotes ventral
T7067 1758-1762 NN denotes part
T7069 1763-1765 IN denotes of
T7070 1766-1769 DT denotes the
T7072 1770-1776 JJ denotes neural
T7071 1777-1781 NN denotes tube
T7073 1782-1783 -LRB- denotes (
T7075 1783-1789 NN denotes Figure
T7076 1790-1792 NN denotes 6b
T7077 1792-1793 , denotes ,
T7074 1793-1794 NN denotes f
T7078 1794-1795 -RRB- denotes )
T7079 1796-1799 CC denotes and
T7080 1800-1802 IN denotes in
T7081 1803-1806 DT denotes the
T7083 1807-1817 VBG denotes developing
T7084 1818-1831 JJ denotes paravertebral
T7082 1832-1839 NNS denotes ganglia
T7085 1840-1841 -LRB- denotes (
T7087 1841-1847 NN denotes Figure
T7088 1848-1850 NN denotes 6d
T7089 1850-1851 , denotes ,
T7086 1851-1852 NN denotes h
T7090 1852-1853 -RRB- denotes )
T7091 1854-1858 IN denotes with
T7092 1859-1863 JJ denotes many
T7094 1864-1873 JJ denotes apoptotic
T7093 1874-1879 NNS denotes cells
T7095 1880-1885 VBG denotes being
T7096 1886-1893 JJ denotes present
T7097 1893-1894 . denotes .
T7098 1894-2072 sentence denotes In these tissues Ptdsr is highly expressed at E12.5 (Figure 2c) but we observed no difference in the number or distribution of apoptotic cells in Ptdsr+/+ and Ptdsr -/- embryos.
T7099 1895-1897 IN denotes In
T7101 1898-1903 DT denotes these
T7102 1904-1911 NNS denotes tissues
T7103 1912-1917 NN denotes Ptdsr
T7100 1918-1920 VBZ denotes is
T7104 1921-1927 RB denotes highly
T7105 1928-1937 VBN denotes expressed
T7106 1938-1940 IN denotes at
T7107 1941-1946 NN denotes E12.5
T7108 1947-1948 -LRB- denotes (
T7110 1948-1954 NN denotes Figure
T7109 1955-1957 NN denotes 2c
T7111 1957-1958 -RRB- denotes )
T7112 1959-1962 CC denotes but
T7113 1963-1965 PRP denotes we
T7114 1966-1974 VBD denotes observed
T7115 1975-1977 DT denotes no
T7116 1978-1988 NN denotes difference
T7117 1989-1991 IN denotes in
T7118 1992-1995 DT denotes the
T7119 1996-2002 NN denotes number
T7120 2003-2005 CC denotes or
T7121 2006-2018 NN denotes distribution
T7122 2019-2021 IN denotes of
T7123 2022-2031 JJ denotes apoptotic
T7124 2032-2037 NNS denotes cells
T7125 2038-2040 IN denotes in
T7126 2041-2046 NN denotes Ptdsr
T7128 2046-2047 SYM denotes +
T7129 2047-2048 HYPH denotes /
T7130 2048-2049 SYM denotes +
T7131 2050-2053 CC denotes and
T7132 2054-2059 NN denotes Ptdsr
T7133 2060-2061 SYM denotes -
T7134 2061-2062 HYPH denotes /
T7135 2062-2063 SYM denotes -
T7127 2064-2071 NNS denotes embryos
T7136 2071-2072 . denotes .
T7137 2072-2312 sentence denotes The same was true for the developing kidney: apoptotic cells were present in Ptdsr+/+ and Ptdsr -/- embryos, in limited numbers, but we failed to detect any differences in the number of apoptotic cells between the genotypes (Figure 6c,6g).
T7138 2073-2076 DT denotes The
T7139 2077-2081 JJ denotes same
T7140 2082-2085 VBD denotes was
T7142 2086-2090 JJ denotes true
T7143 2091-2094 IN denotes for
T7144 2095-2098 DT denotes the
T7146 2099-2109 VBG denotes developing
T7145 2110-2116 NN denotes kidney
T7147 2116-2118 : denotes :
T7148 2118-2127 JJ denotes apoptotic
T7149 2128-2133 NNS denotes cells
T7141 2134-2138 VBD denotes were
T7150 2139-2146 JJ denotes present
T7151 2147-2149 IN denotes in
T7152 2150-2155 NN denotes Ptdsr
T7154 2155-2156 SYM denotes +
T7155 2156-2157 HYPH denotes /
T7156 2157-2158 SYM denotes +
T7157 2159-2162 CC denotes and
T7158 2163-2168 NN denotes Ptdsr
T7159 2169-2170 SYM denotes -
T7160 2170-2171 HYPH denotes /
T7161 2171-2172 SYM denotes -
T7153 2173-2180 NNS denotes embryos
T7162 2180-2182 , denotes ,
T7163 2182-2184 IN denotes in
T7164 2185-2192 JJ denotes limited
T7165 2193-2200 NNS denotes numbers
T7166 2200-2202 , denotes ,
T7167 2202-2205 CC denotes but
T7168 2206-2208 PRP denotes we
T7169 2209-2215 VBD denotes failed
T7170 2216-2218 TO denotes to
T7171 2219-2225 VB denotes detect
T7172 2226-2229 DT denotes any
T7173 2230-2241 NNS denotes differences
T7174 2242-2244 IN denotes in
T7175 2245-2248 DT denotes the
T7176 2249-2255 NN denotes number
T7177 2256-2258 IN denotes of
T7178 2259-2268 JJ denotes apoptotic
T7179 2269-2274 NNS denotes cells
T7180 2275-2282 IN denotes between
T7181 2283-2286 DT denotes the
T7182 2287-2296 NNS denotes genotypes
T7183 2297-2298 -LRB- denotes (
T7185 2298-2304 NN denotes Figure
T7186 2305-2307 NN denotes 6c
T7187 2307-2308 , denotes ,
T7184 2308-2310 NN denotes 6g
T7188 2310-2311 -RRB- denotes )
T7189 2311-2312 . denotes .
T7190 2312-2550 sentence denotes Furthermore, when we continued our analysis of apoptotic cell clearance in vivo at E16.5, E17.5 and E18.5 of embryonic development as well as in neonatal mice, the number and distribution of apoptotic cells was similar in both genotypes.
T7191 2313-2324 RB denotes Furthermore
T7193 2324-2326 , denotes ,
T7194 2326-2330 WRB denotes when
T7196 2331-2333 PRP denotes we
T7195 2334-2343 VBD denotes continued
T7197 2344-2347 PRP$ denotes our
T7198 2348-2356 NN denotes analysis
T7199 2357-2359 IN denotes of
T7200 2360-2369 JJ denotes apoptotic
T7201 2370-2374 NN denotes cell
T7202 2375-2384 NN denotes clearance
T7203 2385-2387 FW denotes in
T7204 2388-2392 FW denotes vivo
T7205 2393-2395 IN denotes at
T7206 2396-2401 NN denotes E16.5
T7207 2401-2403 , denotes ,
T7208 2403-2408 NN denotes E17.5
T7209 2409-2412 CC denotes and
T7210 2413-2418 NN denotes E18.5
T7211 2419-2421 IN denotes of
T7212 2422-2431 JJ denotes embryonic
T7213 2432-2443 NN denotes development
T7214 2444-2446 RB denotes as
T7216 2447-2451 RB denotes well
T7215 2452-2454 IN denotes as
T7217 2455-2457 IN denotes in
T7218 2458-2466 JJ denotes neonatal
T7219 2467-2471 NNS denotes mice
T7220 2471-2473 , denotes ,
T7221 2473-2476 DT denotes the
T7222 2477-2483 NN denotes number
T7223 2484-2487 CC denotes and
T7224 2488-2500 NN denotes distribution
T7225 2501-2503 IN denotes of
T7226 2504-2513 JJ denotes apoptotic
T7227 2514-2519 NNS denotes cells
T7192 2520-2523 VBD denotes was
T7228 2524-2531 JJ denotes similar
T7229 2532-2534 IN denotes in
T7230 2535-2539 DT denotes both
T7231 2540-2549 NNS denotes genotypes
T7232 2549-2550 . denotes .
T7233 2550-2785 sentence denotes As already observed at E12.5, analysis of aCasp3-stained sections of the developing thymus, heart, diaphragm, genital ridge, eyes and retina convincingly showed that there was no impairment in apoptotic cell removal in Ptdsr -/- mice.
T7234 2551-2553 IN denotes As
T7236 2554-2561 RB denotes already
T7235 2562-2570 VBN denotes observed
T7238 2571-2573 IN denotes at
T7239 2574-2579 NN denotes E12.5
T7240 2579-2581 , denotes ,
T7241 2581-2589 NN denotes analysis
T7242 2590-2592 IN denotes of
T7243 2593-2599 NN denotes aCasp3
T7245 2599-2600 HYPH denotes -
T7244 2600-2607 VBN denotes stained
T7246 2608-2616 NNS denotes sections
T7247 2617-2619 IN denotes of
T7248 2620-2623 DT denotes the
T7250 2624-2634 VBG denotes developing
T7249 2635-2641 NN denotes thymus
T7251 2641-2643 , denotes ,
T7252 2643-2648 NN denotes heart
T7253 2648-2650 , denotes ,
T7254 2650-2659 NN denotes diaphragm
T7255 2659-2661 , denotes ,
T7256 2661-2668 JJ denotes genital
T7257 2669-2674 NN denotes ridge
T7258 2674-2676 , denotes ,
T7259 2676-2680 NNS denotes eyes
T7260 2681-2684 CC denotes and
T7261 2685-2691 NN denotes retina
T7262 2692-2704 RB denotes convincingly
T7237 2705-2711 VBD denotes showed
T7263 2712-2716 IN denotes that
T7265 2717-2722 EX denotes there
T7264 2723-2726 VBD denotes was
T7266 2727-2729 DT denotes no
T7267 2730-2740 NN denotes impairment
T7268 2741-2743 IN denotes in
T7269 2744-2753 JJ denotes apoptotic
T7271 2754-2758 NN denotes cell
T7270 2759-2766 NN denotes removal
T7272 2767-2769 IN denotes in
T7273 2770-2775 NN denotes Ptdsr
T7275 2776-2777 SYM denotes -
T7276 2777-2778 HYPH denotes /
T7277 2778-2779 SYM denotes -
T7274 2780-2784 NNS denotes mice
T7278 2784-2785 . denotes .
T7279 2785-3020 sentence denotes Moreover, because Li and colleagues [31] reported impaired clearance of dead cells during lung development in Ptdsr-deficient mice, we examined the rate of apoptosis induction and cell clearance in our Ptdsr-knockout mice in the lung.
T7280 2786-2794 RB denotes Moreover
T7282 2794-2796 , denotes ,
T7283 2796-2803 IN denotes because
T7285 2804-2806 NNP denotes Li
T7286 2807-2810 CC denotes and
T7287 2811-2821 NNS denotes colleagues
T7288 2822-2823 -LRB- denotes [
T7289 2823-2825 CD denotes 31
T7290 2825-2826 -RRB- denotes ]
T7284 2827-2835 VBD denotes reported
T7291 2836-2844 JJ denotes impaired
T7292 2845-2854 NN denotes clearance
T7293 2855-2857 IN denotes of
T7294 2858-2862 JJ denotes dead
T7295 2863-2868 NNS denotes cells
T7296 2869-2875 IN denotes during
T7297 2876-2880 NN denotes lung
T7298 2881-2892 NN denotes development
T7299 2893-2895 IN denotes in
T7300 2896-2901 NN denotes Ptdsr
T7302 2901-2902 HYPH denotes -
T7301 2902-2911 JJ denotes deficient
T7303 2912-2916 NNS denotes mice
T7304 2916-2918 , denotes ,
T7305 2918-2920 PRP denotes we
T7281 2921-2929 VBD denotes examined
T7306 2930-2933 DT denotes the
T7307 2934-2938 NN denotes rate
T7308 2939-2941 IN denotes of
T7309 2942-2951 NN denotes apoptosis
T7310 2952-2961 NN denotes induction
T7311 2962-2965 CC denotes and
T7312 2966-2970 NN denotes cell
T7313 2971-2980 NN denotes clearance
T7314 2981-2983 IN denotes in
T7315 2984-2987 PRP$ denotes our
T7317 2988-2993 NN denotes Ptdsr
T7319 2993-2994 HYPH denotes -
T7318 2994-3002 NN denotes knockout
T7316 3003-3007 NNS denotes mice
T7320 3008-3010 IN denotes in
T7321 3011-3014 DT denotes the
T7322 3015-3019 NN denotes lung
T7323 3019-3020 . denotes .
T7324 3020-3205 sentence denotes Analysis of aCasp3-stained lung tissue from Ptdsr+/+ and Ptdsr -/- mice at E17.5 and P0 demonstrated that apoptosis was an extremely rare event during lung morphogenesis at this stage.
T7325 3021-3029 NN denotes Analysis
T7327 3030-3032 IN denotes of
T7328 3033-3039 NN denotes aCasp3
T7330 3039-3040 HYPH denotes -
T7329 3040-3047 VBN denotes stained
T7332 3048-3052 NN denotes lung
T7331 3053-3059 NN denotes tissue
T7333 3060-3064 IN denotes from
T7334 3065-3070 NN denotes Ptdsr
T7336 3070-3071 SYM denotes +
T7337 3071-3072 HYPH denotes /
T7338 3072-3073 SYM denotes +
T7339 3074-3077 CC denotes and
T7340 3078-3083 NN denotes Ptdsr
T7341 3084-3085 SYM denotes -
T7342 3085-3086 HYPH denotes /
T7343 3086-3087 SYM denotes -
T7335 3088-3092 NNS denotes mice
T7344 3093-3095 IN denotes at
T7345 3096-3101 NN denotes E17.5
T7346 3102-3105 CC denotes and
T7347 3106-3108 NN denotes P0
T7326 3109-3121 VBD denotes demonstrated
T7348 3122-3126 IN denotes that
T7350 3127-3136 NN denotes apoptosis
T7349 3137-3140 VBD denotes was
T7351 3141-3143 DT denotes an
T7353 3144-3153 RB denotes extremely
T7354 3154-3158 JJ denotes rare
T7352 3159-3164 NN denotes event
T7355 3165-3171 IN denotes during
T7356 3172-3176 NN denotes lung
T7357 3177-3190 NN denotes morphogenesis
T7358 3191-3193 IN denotes at
T7359 3194-3198 DT denotes this
T7360 3199-3204 NN denotes stage
T7361 3204-3205 . denotes .
T7362 3205-3326 sentence denotes In addition, there were no differences in the number or distribution of apoptotic cells in Ptdsr -/- and Ptdsr +/+ mice.
T7363 3206-3208 IN denotes In
T7365 3209-3217 NN denotes addition
T7366 3217-3219 , denotes ,
T7367 3219-3224 EX denotes there
T7364 3225-3229 VBD denotes were
T7368 3230-3232 DT denotes no
T7369 3233-3244 NNS denotes differences
T7370 3245-3247 IN denotes in
T7371 3248-3251 DT denotes the
T7372 3252-3258 NN denotes number
T7373 3259-3261 CC denotes or
T7374 3262-3274 NN denotes distribution
T7375 3275-3277 IN denotes of
T7376 3278-3287 JJ denotes apoptotic
T7377 3288-3293 NNS denotes cells
T7378 3294-3296 IN denotes in
T7379 3297-3302 NN denotes Ptdsr
T7381 3303-3304 SYM denotes -
T7382 3304-3305 HYPH denotes /
T7383 3305-3306 SYM denotes -
T7384 3307-3310 CC denotes and
T7385 3311-3316 NN denotes Ptdsr
T7386 3317-3318 SYM denotes +
T7387 3318-3319 HYPH denotes /
T7388 3319-3320 SYM denotes +
T7380 3321-3325 NNS denotes mice
T7389 3325-3326 . denotes .
T7390 3326-3432 sentence denotes Furthermore, we were unable to detect any evidence of tissue necrosis in lungs from Ptdsr-deficient mice.
T7391 3327-3338 RB denotes Furthermore
T7393 3338-3340 , denotes ,
T7394 3340-3342 PRP denotes we
T7392 3343-3347 VBD denotes were
T7395 3348-3354 JJ denotes unable
T7396 3355-3357 TO denotes to
T7397 3358-3364 VB denotes detect
T7398 3365-3368 DT denotes any
T7399 3369-3377 NN denotes evidence
T7400 3378-3380 IN denotes of
T7401 3381-3387 NN denotes tissue
T7402 3388-3396 NN denotes necrosis
T7403 3397-3399 IN denotes in
T7404 3400-3405 NNS denotes lungs
T7405 3406-3410 IN denotes from
T7406 3411-3416 NN denotes Ptdsr
T7408 3416-3417 HYPH denotes -
T7407 3417-3426 JJ denotes deficient
T7409 3427-3431 NNS denotes mice
T7410 3431-3432 . denotes .
T7411 3432-3620 sentence denotes In contrast to the report of Li et al. [31], we never observed recruitment of neutrophils or other signs of pulmonary inflammation at any stage of development in our Ptdsr-deficient mice.
T7412 3433-3435 IN denotes In
T7414 3436-3444 NN denotes contrast
T7415 3445-3447 IN denotes to
T7416 3448-3451 DT denotes the
T7417 3452-3458 NN denotes report
T7418 3459-3461 IN denotes of
T7419 3462-3464 NNP denotes Li
T7420 3465-3467 FW denotes et
T7421 3468-3471 FW denotes al.
T7422 3472-3473 -LRB- denotes [
T7423 3473-3475 CD denotes 31
T7424 3475-3476 -RRB- denotes ]
T7425 3476-3478 , denotes ,
T7426 3478-3480 PRP denotes we
T7427 3481-3486 RB denotes never
T7413 3487-3495 VBD denotes observed
T7428 3496-3507 NN denotes recruitment
T7429 3508-3510 IN denotes of
T7430 3511-3522 NNS denotes neutrophils
T7431 3523-3525 CC denotes or
T7432 3526-3531 JJ denotes other
T7433 3532-3537 NNS denotes signs
T7434 3538-3540 IN denotes of
T7435 3541-3550 JJ denotes pulmonary
T7436 3551-3563 NN denotes inflammation
T7437 3564-3566 IN denotes at
T7438 3567-3570 DT denotes any
T7439 3571-3576 NN denotes stage
T7440 3577-3579 IN denotes of
T7441 3580-3591 NN denotes development
T7442 3592-3594 IN denotes in
T7443 3595-3598 PRP$ denotes our
T7445 3599-3604 NN denotes Ptdsr
T7447 3604-3605 HYPH denotes -
T7446 3605-3614 JJ denotes deficient
T7444 3615-3619 NNS denotes mice
T7448 3619-3620 . denotes .
T7449 3620-3830 sentence denotes To analyze whether macrophages are recruited into areas where apoptosis is prominent during embryogenesis, we stained consecutive serial sections either with the macrophage surface marker F4/80 or with aCasp3.
T7450 3621-3623 TO denotes To
T7451 3624-3631 VB denotes analyze
T7453 3632-3639 IN denotes whether
T7455 3640-3651 NNS denotes macrophages
T7456 3652-3655 VBP denotes are
T7454 3656-3665 VBN denotes recruited
T7457 3666-3670 IN denotes into
T7458 3671-3676 NNS denotes areas
T7459 3677-3682 WRB denotes where
T7461 3683-3692 NN denotes apoptosis
T7460 3693-3695 VBZ denotes is
T7462 3696-3705 JJ denotes prominent
T7463 3706-3712 IN denotes during
T7464 3713-3726 NN denotes embryogenesis
T7465 3726-3728 , denotes ,
T7466 3728-3730 PRP denotes we
T7452 3731-3738 VBD denotes stained
T7467 3739-3750 JJ denotes consecutive
T7469 3751-3757 JJ denotes serial
T7468 3758-3766 NNS denotes sections
T7470 3767-3773 CC denotes either
T7471 3774-3778 IN denotes with
T7472 3779-3782 DT denotes the
T7474 3783-3793 NN denotes macrophage
T7475 3794-3801 NN denotes surface
T7473 3802-3808 NN denotes marker
T7476 3809-3811 NN denotes F4
T7477 3811-3812 HYPH denotes /
T7478 3812-3814 CD denotes 80
T7479 3815-3817 CC denotes or
T7480 3818-3822 IN denotes with
T7481 3823-3829 NN denotes aCasp3
T7482 3829-3830 . denotes .
T7483 3830-3910 sentence denotes Surprisingly, there was no co-localization of macrophages with apoptotic cells.
T7484 3831-3843 RB denotes Surprisingly
T7486 3843-3845 , denotes ,
T7487 3845-3850 EX denotes there
T7485 3851-3854 VBD denotes was
T7488 3855-3857 DT denotes no
T7489 3858-3873 NN denotes co-localization
T7490 3874-3876 IN denotes of
T7491 3877-3888 NNS denotes macrophages
T7492 3889-3893 IN denotes with
T7493 3894-3903 JJ denotes apoptotic
T7494 3904-3909 NNS denotes cells
T7495 3909-3910 . denotes .
T7496 3910-4083 sentence denotes In virtually all embryonic tissues, apoptotic cells and macrophages were localized in different compartments (Figure 6e,6i; and see also Additional data file 1, Figure S1).
T7497 3911-3913 IN denotes In
T7499 3914-3923 RB denotes virtually
T7501 3924-3927 DT denotes all
T7502 3928-3937 JJ denotes embryonic
T7500 3938-3945 NNS denotes tissues
T7503 3945-3947 , denotes ,
T7504 3947-3956 JJ denotes apoptotic
T7505 3957-3962 NNS denotes cells
T7506 3963-3966 CC denotes and
T7507 3967-3978 NNS denotes macrophages
T7508 3979-3983 VBD denotes were
T7498 3984-3993 VBN denotes localized
T7509 3994-3996 IN denotes in
T7510 3997-4006 JJ denotes different
T7511 4007-4019 NNS denotes compartments
T7512 4020-4021 -LRB- denotes (
T7514 4021-4027 NN denotes Figure
T7515 4028-4030 NN denotes 6e
T7516 4030-4031 , denotes ,
T7513 4031-4033 NN denotes 6i
T7517 4033-4034 : denotes ;
T7518 4035-4038 CC denotes and
T7519 4039-4042 VB denotes see
T7520 4043-4047 RB denotes also
T7521 4048-4058 JJ denotes Additional
T7522 4059-4063 NNS denotes data
T7523 4064-4068 NN denotes file
T7524 4069-4070 CD denotes 1
T7525 4070-4072 , denotes ,
T7526 4072-4078 NN denotes Figure
T7527 4079-4081 NN denotes S1
T7528 4081-4082 -RRB- denotes )
T7529 4082-4083 . denotes .
T7530 4083-4249 sentence denotes This suggests that at this stage of development it is mainly neighboring cells that are involved in removal of apoptotic cells, rather than professional macrophages.
T7531 4084-4088 DT denotes This
T7532 4089-4097 VBZ denotes suggests
T7533 4098-4102 IN denotes that
T7535 4103-4105 IN denotes at
T7536 4106-4110 DT denotes this
T7537 4111-4116 NN denotes stage
T7538 4117-4119 IN denotes of
T7539 4120-4131 NN denotes development
T7540 4132-4134 PRP denotes it
T7534 4135-4137 VBZ denotes is
T7541 4138-4144 RB denotes mainly
T7542 4145-4156 VBG denotes neighboring
T7543 4157-4162 NNS denotes cells
T7544 4163-4167 WDT denotes that
T7546 4168-4171 VBP denotes are
T7545 4172-4180 VBN denotes involved
T7547 4181-4183 IN denotes in
T7548 4184-4191 NN denotes removal
T7549 4192-4194 IN denotes of
T7550 4195-4204 JJ denotes apoptotic
T7551 4205-4210 NNS denotes cells
T7552 4210-4212 , denotes ,
T7553 4212-4218 RB denotes rather
T7554 4219-4223 IN denotes than
T7555 4224-4236 JJ denotes professional
T7556 4237-4248 NNS denotes macrophages
T7557 4248-4249 . denotes .
T7558 4249-4502 sentence denotes In summary, our analysis in vivo did not reveal any impairment in apoptotic cell clearance in Ptdsr-deficient embryos during development and further suggests that phagocytosis of apoptotic cells is mainly mediated by non-professional 'bystander' cells.
T7559 4250-4252 IN denotes In
T7561 4253-4260 NN denotes summary
T7562 4260-4262 , denotes ,
T7563 4262-4265 PRP$ denotes our
T7564 4266-4274 NN denotes analysis
T7565 4275-4277 FW denotes in
T7566 4278-4282 FW denotes vivo
T7567 4283-4286 VBD denotes did
T7568 4287-4290 RB denotes not
T7560 4291-4297 VB denotes reveal
T7569 4298-4301 DT denotes any
T7570 4302-4312 NN denotes impairment
T7571 4313-4315 IN denotes in
T7572 4316-4325 JJ denotes apoptotic
T7574 4326-4330 NN denotes cell
T7573 4331-4340 NN denotes clearance
T7575 4341-4343 IN denotes in
T7576 4344-4349 NN denotes Ptdsr
T7578 4349-4350 HYPH denotes -
T7577 4350-4359 JJ denotes deficient
T7579 4360-4367 NNS denotes embryos
T7580 4368-4374 IN denotes during
T7581 4375-4386 NN denotes development
T7582 4387-4390 CC denotes and
T7583 4391-4398 RBR denotes further
T7584 4399-4407 VBZ denotes suggests
T7585 4408-4412 IN denotes that
T7587 4413-4425 NN denotes phagocytosis
T7588 4426-4428 IN denotes of
T7589 4429-4438 JJ denotes apoptotic
T7590 4439-4444 NNS denotes cells
T7591 4445-4447 VBZ denotes is
T7592 4448-4454 RB denotes mainly
T7586 4455-4463 VBN denotes mediated
T7593 4464-4466 IN denotes by
T7594 4467-4483 JJ denotes non-professional
T7596 4484-4485 `` denotes '
T7597 4485-4494 NN denotes bystander
T7598 4494-4495 '' denotes '
T7595 4496-4501 NNS denotes cells
T7599 4501-4502 . denotes .
T7600 4502-4744 sentence denotes To determine whether macrophages from Ptdsr-knockout mice were impaired in the efficacy of apoptotic cell uptake in vitro, we performed phagocytosis assays with fetal-liver-derived macrophages (FLDMs) and quantified their phagocytosis rates.
T7601 4503-4505 TO denotes To
T7602 4506-4515 VB denotes determine
T7604 4516-4523 IN denotes whether
T7606 4524-4535 NNS denotes macrophages
T7607 4536-4540 IN denotes from
T7608 4541-4546 NN denotes Ptdsr
T7610 4546-4547 HYPH denotes -
T7609 4547-4555 NN denotes knockout
T7611 4556-4560 NNS denotes mice
T7612 4561-4565 VBD denotes were
T7605 4566-4574 VBN denotes impaired
T7613 4575-4577 IN denotes in
T7614 4578-4581 DT denotes the
T7615 4582-4590 NN denotes efficacy
T7616 4591-4593 IN denotes of
T7617 4594-4603 JJ denotes apoptotic
T7618 4604-4608 NN denotes cell
T7619 4609-4615 NN denotes uptake
T7620 4616-4618 FW denotes in
T7621 4619-4624 FW denotes vitro
T7622 4624-4626 , denotes ,
T7623 4626-4628 PRP denotes we
T7603 4629-4638 VBD denotes performed
T7624 4639-4651 NN denotes phagocytosis
T7625 4652-4658 NNS denotes assays
T7626 4659-4663 IN denotes with
T7627 4664-4669 JJ denotes fetal
T7629 4669-4670 HYPH denotes -
T7628 4670-4675 NN denotes liver
T7631 4675-4676 HYPH denotes -
T7630 4676-4683 VBN denotes derived
T7632 4684-4695 NNS denotes macrophages
T7633 4696-4697 -LRB- denotes (
T7634 4697-4702 NNS denotes FLDMs
T7635 4702-4703 -RRB- denotes )
T7636 4704-4707 CC denotes and
T7637 4708-4718 VBD denotes quantified
T7638 4719-4724 PRP$ denotes their
T7640 4725-4737 NN denotes phagocytosis
T7639 4738-4743 NNS denotes rates
T7641 4743-4744 . denotes .
T7642 4744-4880 sentence denotes Phagocytosis of apoptotic thymocytes was investigated at 60, 90 and 120 minutes after addition of target cells in the absence of serum.
T7643 4745-4757 NN denotes Phagocytosis
T7645 4758-4760 IN denotes of
T7646 4761-4770 JJ denotes apoptotic
T7647 4771-4781 NNS denotes thymocytes
T7648 4782-4785 VBD denotes was
T7644 4786-4798 VBN denotes investigated
T7649 4799-4801 IN denotes at
T7650 4802-4804 CD denotes 60
T7652 4804-4806 , denotes ,
T7653 4806-4808 CD denotes 90
T7654 4809-4812 CC denotes and
T7655 4813-4816 CD denotes 120
T7651 4817-4824 NNS denotes minutes
T7656 4825-4830 IN denotes after
T7657 4831-4839 NN denotes addition
T7658 4840-4842 IN denotes of
T7659 4843-4849 NN denotes target
T7660 4850-4855 NNS denotes cells
T7661 4856-4858 IN denotes in
T7662 4859-4862 DT denotes the
T7663 4863-4870 NN denotes absence
T7664 4871-4873 IN denotes of
T7665 4874-4879 NN denotes serum
T7666 4879-4880 . denotes .
T7667 4880-5162 sentence denotes Analysis of phagocytosis rates by flow cytometric analysis (FACS) revealed no differences in the efficacy of apoptotic cell uptake between Ptdsr -/- and Ptdsr+/+ macrophages and demonstrated no differences in apoptotic cell engulfment between selected time points (data not shown).
T7668 4881-4889 NN denotes Analysis
T7670 4890-4892 IN denotes of
T7671 4893-4905 NN denotes phagocytosis
T7672 4906-4911 NNS denotes rates
T7673 4912-4914 IN denotes by
T7674 4915-4919 NN denotes flow
T7676 4920-4930 JJ denotes cytometric
T7675 4931-4939 NN denotes analysis
T7677 4940-4941 -LRB- denotes (
T7678 4941-4945 NN denotes FACS
T7679 4945-4946 -RRB- denotes )
T7669 4947-4955 VBD denotes revealed
T7680 4956-4958 DT denotes no
T7681 4959-4970 NNS denotes differences
T7682 4971-4973 IN denotes in
T7683 4974-4977 DT denotes the
T7684 4978-4986 NN denotes efficacy
T7685 4987-4989 IN denotes of
T7686 4990-4999 JJ denotes apoptotic
T7688 5000-5004 NN denotes cell
T7687 5005-5011 NN denotes uptake
T7689 5012-5019 IN denotes between
T7690 5020-5025 NN denotes Ptdsr
T7692 5026-5027 SYM denotes -
T7693 5027-5028 HYPH denotes /
T7694 5028-5029 SYM denotes -
T7695 5030-5033 CC denotes and
T7696 5034-5039 NN denotes Ptdsr
T7697 5039-5040 SYM denotes +
T7698 5040-5041 HYPH denotes /
T7699 5041-5042 SYM denotes +
T7691 5043-5054 NNS denotes macrophages
T7700 5055-5058 CC denotes and
T7701 5059-5071 VBD denotes demonstrated
T7702 5072-5074 DT denotes no
T7703 5075-5086 NNS denotes differences
T7704 5087-5089 IN denotes in
T7705 5090-5099 JJ denotes apoptotic
T7707 5100-5104 NN denotes cell
T7706 5105-5115 NN denotes engulfment
T7708 5116-5123 IN denotes between
T7709 5124-5132 VBN denotes selected
T7711 5133-5137 NN denotes time
T7710 5138-5144 NNS denotes points
T7712 5145-5146 -LRB- denotes (
T7714 5146-5150 NNS denotes data
T7715 5151-5154 RB denotes not
T7713 5155-5160 VBN denotes shown
T7716 5160-5161 -RRB- denotes )
T7717 5161-5162 . denotes .
T7718 5162-5479 sentence denotes To re-examine and further independently validate the result of normal apoptotic cell uptake by Ptdsr -/- macrophages, we performed phagocytosis assays for 60 min and determined the percentage of macrophages that had engulfed apoptotic cells, in a total of at least 300 macrophages counted by fluorescence microscopy.
T7719 5163-5165 TO denotes To
T7720 5166-5176 VB denotes re-examine
T7722 5177-5180 CC denotes and
T7723 5181-5188 RBR denotes further
T7725 5189-5202 RB denotes independently
T7724 5203-5211 VB denotes validate
T7726 5212-5215 DT denotes the
T7727 5216-5222 NN denotes result
T7728 5223-5225 IN denotes of
T7729 5226-5232 JJ denotes normal
T7731 5233-5242 JJ denotes apoptotic
T7732 5243-5247 NN denotes cell
T7730 5248-5254 NN denotes uptake
T7733 5255-5257 IN denotes by
T7734 5258-5263 NN denotes Ptdsr
T7736 5264-5265 SYM denotes -
T7737 5265-5266 HYPH denotes /
T7738 5266-5267 SYM denotes -
T7735 5268-5279 NNS denotes macrophages
T7739 5279-5281 , denotes ,
T7740 5281-5283 PRP denotes we
T7721 5284-5293 VBD denotes performed
T7741 5294-5306 NN denotes phagocytosis
T7742 5307-5313 NNS denotes assays
T7743 5314-5317 IN denotes for
T7744 5318-5320 CD denotes 60
T7745 5321-5324 NNS denotes min
T7746 5325-5328 CC denotes and
T7747 5329-5339 VBD denotes determined
T7748 5340-5343 DT denotes the
T7749 5344-5354 NN denotes percentage
T7750 5355-5357 IN denotes of
T7751 5358-5369 NNS denotes macrophages
T7752 5370-5374 WDT denotes that
T7754 5375-5378 VBD denotes had
T7753 5379-5387 VBN denotes engulfed
T7755 5388-5397 JJ denotes apoptotic
T7756 5398-5403 NNS denotes cells
T7757 5403-5405 , denotes ,
T7758 5405-5407 IN denotes in
T7759 5408-5409 DT denotes a
T7760 5410-5415 NN denotes total
T7761 5416-5418 IN denotes of
T7762 5419-5421 RB denotes at
T7764 5422-5427 RBS denotes least
T7763 5428-5431 CD denotes 300
T7765 5432-5443 NNS denotes macrophages
T7766 5444-5451 VBN denotes counted
T7767 5452-5454 IN denotes by
T7768 5455-5467 NN denotes fluorescence
T7769 5468-5478 NN denotes microscopy
T7770 5478-5479 . denotes .
T7771 5479-5634 sentence denotes Phagocytosed, 5-carboxytetramethylrhodamine- (TAMRA-) labeled apoptotic cells were identified as being engulfed by inclusion in F4/80-labeled macrophages.
T7772 5480-5492 VBN denotes Phagocytosed
T7774 5492-5494 , denotes ,
T7775 5494-5495 CD denotes 5
T7777 5495-5496 HYPH denotes -
T7776 5496-5523 NN denotes carboxytetramethylrhodamine
T7779 5523-5524 HYPH denotes -
T7780 5525-5526 -LRB- denotes (
T7781 5526-5531 NN denotes TAMRA
T7782 5531-5532 HYPH denotes -
T7783 5532-5533 -RRB- denotes )
T7778 5534-5541 VBN denotes labeled
T7784 5542-5551 JJ denotes apoptotic
T7773 5552-5557 NNS denotes cells
T7786 5558-5562 VBD denotes were
T7785 5563-5573 VBN denotes identified
T7787 5574-5576 IN denotes as
T7789 5577-5582 VBG denotes being
T7788 5583-5591 VBN denotes engulfed
T7790 5592-5594 IN denotes by
T7791 5595-5604 NN denotes inclusion
T7792 5605-5607 IN denotes in
T7793 5608-5610 NN denotes F4
T7795 5610-5611 HYPH denotes /
T7796 5611-5613 CD denotes 80
T7797 5613-5614 HYPH denotes -
T7794 5614-5621 VBN denotes labeled
T7798 5622-5633 NNS denotes macrophages
T7799 5633-5634 . denotes .
T7800 5634-5757 sentence denotes Analysis was done independently by three investigators who were not aware of macrophage genotypes (Ptdsr -/- or Ptdsr+/+).
T7801 5635-5643 NN denotes Analysis
T7803 5644-5647 VBD denotes was
T7802 5648-5652 VBN denotes done
T7804 5653-5666 RB denotes independently
T7805 5667-5669 IN denotes by
T7806 5670-5675 CD denotes three
T7807 5676-5689 NNS denotes investigators
T7808 5690-5693 WP denotes who
T7809 5694-5698 VBD denotes were
T7810 5699-5702 RB denotes not
T7811 5703-5708 JJ denotes aware
T7812 5709-5711 IN denotes of
T7813 5712-5722 NN denotes macrophage
T7814 5723-5732 NNS denotes genotypes
T7815 5733-5734 -LRB- denotes (
T7816 5734-5739 NN denotes Ptdsr
T7817 5740-5741 SYM denotes -
T7818 5741-5742 HYPH denotes /
T7819 5742-5743 SYM denotes -
T7820 5744-5746 CC denotes or
T7821 5747-5752 NN denotes Ptdsr
T7822 5752-5753 SYM denotes +
T7823 5753-5754 HYPH denotes /
T7824 5754-5755 SYM denotes +
T7825 5755-5756 -RRB- denotes )
T7826 5756-5757 . denotes .
T7827 5757-5979 sentence denotes Again, no differences were found in the percentage of macrophages that had engulfed apoptotic cells (Figure 7a,c,e) or in the relative number of phagocytosed apoptotic cells per macrophage (phagocytotic index; Figure 7f).
T7828 5758-5763 RB denotes Again
T7830 5763-5765 , denotes ,
T7831 5765-5767 DT denotes no
T7832 5768-5779 NNS denotes differences
T7833 5780-5784 VBD denotes were
T7829 5785-5790 VBN denotes found
T7834 5791-5793 IN denotes in
T7835 5794-5797 DT denotes the
T7836 5798-5808 NN denotes percentage
T7837 5809-5811 IN denotes of
T7838 5812-5823 NNS denotes macrophages
T7839 5824-5828 WDT denotes that
T7841 5829-5832 VBD denotes had
T7840 5833-5841 VBN denotes engulfed
T7842 5842-5851 JJ denotes apoptotic
T7843 5852-5857 NNS denotes cells
T7844 5858-5859 -LRB- denotes (
T7846 5859-5865 NN denotes Figure
T7847 5866-5868 NN denotes 7a
T7848 5868-5869 , denotes ,
T7849 5869-5870 NN denotes c
T7850 5870-5871 , denotes ,
T7845 5871-5872 NN denotes e
T7851 5872-5873 -RRB- denotes )
T7852 5874-5876 CC denotes or
T7853 5877-5879 IN denotes in
T7854 5880-5883 DT denotes the
T7856 5884-5892 JJ denotes relative
T7855 5893-5899 NN denotes number
T7857 5900-5902 IN denotes of
T7858 5903-5915 VBN denotes phagocytosed
T7860 5916-5925 JJ denotes apoptotic
T7859 5926-5931 NNS denotes cells
T7861 5932-5935 IN denotes per
T7862 5936-5946 NN denotes macrophage
T7863 5947-5948 -LRB- denotes (
T7865 5948-5960 JJ denotes phagocytotic
T7866 5961-5966 NN denotes index
T7867 5966-5967 : denotes ;
T7868 5968-5974 NN denotes Figure
T7864 5975-5977 NN denotes 7f
T7869 5977-5978 -RRB- denotes )
T7870 5978-5979 . denotes .
T7871 5979-6134 sentence denotes Moreover, single Ptdsr -/-macrophages could be identified that had engulfed even more apoptotic target cells than had wild-type macrophages (Figure 7b,d).
T7872 5980-5988 RB denotes Moreover
T7874 5988-5990 , denotes ,
T7875 5990-5996 JJ denotes single
T7877 5997-6002 NN denotes Ptdsr
T7878 6003-6004 SYM denotes -
T7879 6004-6005 HYPH denotes /
T7880 6005-6006 SYM denotes -
T7876 6006-6017 NNS denotes macrophages
T7881 6018-6023 MD denotes could
T7882 6024-6026 VB denotes be
T7873 6027-6037 VBN denotes identified
T7883 6038-6042 WDT denotes that
T7885 6043-6046 VBD denotes had
T7884 6047-6055 VBN denotes engulfed
T7886 6056-6060 RB denotes even
T7887 6061-6065 JJR denotes more
T7889 6066-6075 JJ denotes apoptotic
T7890 6076-6082 NN denotes target
T7888 6083-6088 NNS denotes cells
T7891 6089-6093 IN denotes than
T7892 6094-6097 VBD denotes had
T7893 6098-6102 JJ denotes wild
T7895 6102-6103 HYPH denotes -
T7894 6103-6107 NN denotes type
T7896 6108-6119 NNS denotes macrophages
T7897 6120-6121 -LRB- denotes (
T7899 6121-6127 NN denotes Figure
T7900 6128-6130 NN denotes 7b
T7901 6130-6131 , denotes ,
T7898 6131-6132 NN denotes d
T7902 6132-6133 -RRB- denotes )
T7903 6133-6134 . denotes .
T7904 6134-6319 sentence denotes Thus, Ptdsr-deficient macrophages had a normal ability to ingest apoptotic cells and were not impaired in recognition or phagocytosis of cells that had undergone programmed cell death.
T7905 6135-6139 RB denotes Thus
T7907 6139-6141 , denotes ,
T7908 6141-6146 NN denotes Ptdsr
T7910 6146-6147 HYPH denotes -
T7909 6147-6156 JJ denotes deficient
T7911 6157-6168 NNS denotes macrophages
T7906 6169-6172 VBD denotes had
T7912 6173-6174 DT denotes a
T7914 6175-6181 JJ denotes normal
T7913 6182-6189 NN denotes ability
T7915 6190-6192 TO denotes to
T7916 6193-6199 VB denotes ingest
T7917 6200-6209 JJ denotes apoptotic
T7918 6210-6215 NNS denotes cells
T7919 6216-6219 CC denotes and
T7920 6220-6224 VBD denotes were
T7922 6225-6228 RB denotes not
T7921 6229-6237 VBN denotes impaired
T7923 6238-6240 IN denotes in
T7924 6241-6252 NN denotes recognition
T7925 6253-6255 CC denotes or
T7926 6256-6268 NN denotes phagocytosis
T7927 6269-6271 IN denotes of
T7928 6272-6277 NNS denotes cells
T7929 6278-6282 WDT denotes that
T7931 6283-6286 VBD denotes had
T7930 6287-6296 VBN denotes undergone
T7932 6297-6307 VBN denotes programmed
T7934 6308-6312 NN denotes cell
T7933 6313-6318 NN denotes death
T7935 6318-6319 . denotes .
R3613 T6746 T6747 nsubj Phagocytosis,is
R3614 T6748 T6746 cc and,Phagocytosis
R3615 T6749 T6746 conj clearance,Phagocytosis
R3616 T6750 T6746 prep of,Phagocytosis
R3617 T6751 T6752 amod apoptotic,cells
R3618 T6752 T6750 pobj cells,of
R3619 T6753 T6747 acomp normal,is
R3620 T6754 T6747 prep in,is
R3621 T6755 T6756 npadvmod Ptdsr,deficient
R3622 T6756 T6758 amod deficient,mice
R3623 T6757 T6756 punct -,deficient
R3624 T6758 T6754 pobj mice,in
R3625 T6760 T6761 nsubj We,tested
R3626 T6762 T6761 advmod next,tested
R3627 T6763 T6764 mark whether,required
R3628 T6764 T6761 ccomp required,tested
R3629 T6765 T6764 nsubjpass Ptdsr,required
R3630 T6766 T6764 auxpass is,required
R3631 T6767 T6764 advmod functionally,required
R3632 T6768 T6764 prep for,required
R3633 T6769 T6770 det the,clearance
R3634 T6770 T6768 pobj clearance,for
R3635 T6771 T6770 prep of,clearance
R3636 T6772 T6773 amod apoptotic,cells
R3637 T6773 T6771 pobj cells,of
R3638 T6774 T6761 punct .,tested
R3639 T6776 T6777 nsubj We,started
R3640 T6778 T6777 prep with,started
R3641 T6779 T6780 det an,investigation
R3642 T6780 T6778 pobj investigation,with
R3643 T6781 T6780 prep of,investigation
R3644 T6782 T6783 compound cell,death
R3645 T6783 T6781 pobj death,of
R3646 T6784 T6785 advmod in,vivo
R3647 T6785 T6783 advmod vivo,death
R3648 T6786 T6783 prep in,death
R3649 T6787 T6788 det the,areas
R3650 T6788 T6786 pobj areas,in
R3651 T6789 T6788 amod interdigital,areas
R3652 T6790 T6788 prep of,areas
R3653 T6791 T6792 det the,limbs
R3654 T6792 T6790 pobj limbs,of
R3655 T6793 T6792 amod developing,limbs
R3656 T6794 T6777 punct .,started
R3657 T6796 T6797 nsubj Apoptosis,occurs
R3658 T6798 T6796 prep of,Apoptosis
R3659 T6799 T6800 amod interdigital,cells
R3660 T6800 T6798 pobj cells,of
R3661 T6801 T6796 prep in,Apoptosis
R3662 T6802 T6803 det the,mesenchyme
R3663 T6803 T6801 pobj mesenchyme,in
R3664 T6804 T6803 amod distal,mesenchyme
R3665 T6805 T6803 prep of,mesenchyme
R3666 T6806 T6807 compound limb,buds
R3667 T6807 T6805 pobj buds,of
R3668 T6808 T6809 advmod most,prominently
R3669 T6809 T6797 advmod prominently,occurs
R3670 T6810 T6797 prep from,occurs
R3671 T6811 T6812 amod developmental,E12.0
R3672 T6812 T6810 pobj E12.0,from
R3673 T6813 T6812 compound stages,E12.0
R3674 T6814 T6812 prep to,E12.0
R3675 T6815 T6814 pobj E13.5,to
R3676 T6816 T6797 cc and,occurs
R3677 T6817 T6818 aux can,examined
R3678 T6818 T6797 conj examined,occurs
R3679 T6819 T6818 auxpass be,examined
R3680 T6820 T6818 advmod easily,examined
R3681 T6821 T6822 advmod in,situ
R3682 T6822 T6818 advmod situ,examined
R3683 T6823 T6818 prep by,examined
R3684 T6824 T6825 amod whole,mount
R3685 T6825 T6827 nmod mount,end
R3686 T6826 T6825 punct -,mount
R3687 T6827 T6823 pobj end,by
R3688 T6828 T6827 amod terminal,end
R3689 T6829 T6827 nmod deoxynucleotide,end
R3690 T6830 T6831 npadvmod transferase,mediated
R3691 T6831 T6827 amod mediated,end
R3692 T6832 T6831 punct -,mediated
R3693 T6833 T6827 compound UTP,end
R3694 T6834 T6827 punct -,end
R3695 T6835 T6827 amod labeling,end
R3696 T6836 T6827 punct (,end
R3697 T6837 T6827 appos TUNEL,end
R3698 T6838 T6797 punct ),occurs
R3699 T6839 T6797 punct .,occurs
R3700 T6841 T6842 nsubj We,compared
R3701 T6843 T6844 det the,pattern
R3702 T6844 T6842 dobj pattern,compared
R3703 T6845 T6844 prep of,pattern
R3704 T6846 T6847 amod interdigital,death
R3705 T6847 T6845 pobj death,of
R3706 T6848 T6847 compound cell,death
R3707 T6849 T6842 prep in,compared
R3708 T6850 T6851 amod fore,buds
R3709 T6851 T6849 pobj buds,in
R3710 T6852 T6850 cc and,fore
R3711 T6853 T6850 conj hind,fore
R3712 T6854 T6851 compound limb,buds
R3713 T6855 T6851 prep from,buds
R3714 T6856 T6857 nmod Ptdsr,mice
R3715 T6857 T6855 pobj mice,from
R3716 T6858 T6856 punct -,Ptdsr
R3717 T6859 T6856 punct /,Ptdsr
R3718 T6860 T6856 punct -,Ptdsr
R3719 T6861 T6862 punct (,3
R3720 T6862 T6856 parataxis 3,Ptdsr
R3721 T6863 T6862 nsubj n,3
R3722 T6864 T6862 punct =,3
R3723 T6865 T6862 punct ),3
R3724 T6866 T6856 cc and,Ptdsr
R3725 T6867 T6856 conj Ptdsr,Ptdsr
R3726 T6868 T6867 punct +,Ptdsr
R3727 T6869 T6867 punct /,Ptdsr
R3728 T6870 T6867 punct +,Ptdsr
R3729 T6871 T6872 punct (,3
R3730 T6872 T6867 parataxis 3,Ptdsr
R3731 T6873 T6872 nsubj n,3
R3732 T6874 T6872 punct =,3
R3733 T6875 T6872 punct ),3
R3734 T6876 T6857 prep at,mice
R3735 T6877 T6876 pobj E12.5,at
R3736 T6878 T6877 cc and,E12.5
R3737 T6879 T6877 conj E13.5,E12.5
R3738 T6880 T6842 punct .,compared
R3739 T6882 T6883 det No,differences
R3740 T6883 T6884 nsubjpass differences,observed
R3741 T6885 T6883 prep in,differences
R3742 T6886 T6885 pobj accumulation,in
R3743 T6887 T6886 prep of,accumulation
R3744 T6888 T6889 npadvmod TUNEL,positive
R3745 T6889 T6891 amod positive,corpses
R3746 T6890 T6889 punct -,positive
R3747 T6891 T6887 pobj corpses,of
R3748 T6892 T6891 compound cell,corpses
R3749 T6893 T6884 auxpass were,observed
R3750 T6894 T6884 prep between,observed
R3751 T6895 T6896 det the,genotypes
R3752 T6896 T6894 pobj genotypes,between
R3753 T6897 T6896 nummod two,genotypes
R3754 T6898 T6899 punct (,6a
R3755 T6899 T6884 parataxis 6a,observed
R3756 T6900 T6899 compound Figure,6a
R3757 T6901 T6899 punct ),6a
R3758 T6902 T6884 punct .,observed
R3759 T6904 T6905 det The,kinetics
R3760 T6905 T6906 nsubj kinetics,was
R3761 T6907 T6905 prep of,kinetics
R3762 T6908 T6909 compound cell,death
R3763 T6909 T6910 compound death,occurrence
R3764 T6910 T6907 pobj occurrence,of
R3765 T6911 T6910 cc and,occurrence
R3766 T6912 T6910 conj regression,occurrence
R3767 T6913 T6912 prep of,regression
R3768 T6914 T6915 det the,web
R3769 T6915 T6913 pobj web,of
R3770 T6916 T6915 amod interdigital,web
R3771 T6917 T6906 acomp similar,was
R3772 T6918 T6906 prep in,was
R3773 T6919 T6920 amod wild,type
R3774 T6920 T6922 nmod type,littermates
R3775 T6921 T6920 punct -,type
R3776 T6922 T6918 pobj littermates,in
R3777 T6923 T6920 cc and,type
R3778 T6924 T6920 conj mutant,type
R3779 T6925 T6906 punct ", ",was
R3780 T6926 T6906 advcl providing,was
R3781 T6927 T6928 det no,evidence
R3782 T6928 T6926 dobj evidence,providing
R3783 T6929 T6930 mark that,associated
R3784 T6930 T6928 acl associated,evidence
R3785 T6931 T6932 compound Ptdsr,deficiency
R3786 T6932 T6930 nsubjpass deficiency,associated
R3787 T6933 T6932 punct -,deficiency
R3788 T6934 T6930 auxpass is,associated
R3789 T6935 T6930 prep with,associated
R3790 T6936 T6937 amod impaired,clearance
R3791 T6937 T6935 pobj clearance,with
R3792 T6938 T6937 prep of,clearance
R3793 T6939 T6940 amod apoptotic,cells
R3794 T6940 T6938 pobj cells,of
R3795 T6941 T6940 amod interdigital,cells
R3796 T6942 T6937 prep during,clearance
R3797 T6943 T6944 compound limb,development
R3798 T6944 T6942 pobj development,during
R3799 T6945 T6906 punct .,was
R3800 T6947 T6948 aux To,investigate
R3801 T6948 T6949 advcl investigate,stained
R3802 T6950 T6948 advmod further,investigate
R3803 T6951 T6952 mark whether,impaired
R3804 T6952 T6948 ccomp impaired,investigate
R3805 T6953 T6952 nsubjpass removal,impaired
R3806 T6954 T6953 prep of,removal
R3807 T6955 T6956 amod apoptotic,cells
R3808 T6956 T6954 pobj cells,of
R3809 T6957 T6952 auxpass is,impaired
R3810 T6958 T6952 prep in,impaired
R3811 T6959 T6960 nmod Ptdsr,mice
R3812 T6960 T6958 pobj mice,in
R3813 T6961 T6959 punct -,Ptdsr
R3814 T6962 T6959 punct /,Ptdsr
R3815 T6963 T6959 punct -,Ptdsr
R3816 T6964 T6949 punct ", ",stained
R3817 T6965 T6949 nsubj we,stained
R3818 T6966 T6949 advmod immunohistochemically,stained
R3819 T6967 T6949 prep for,stained
R3820 T6968 T6969 amod activated,caspase
R3821 T6969 T6967 pobj caspase,for
R3822 T6970 T6969 nummod 3,caspase
R3823 T6971 T6969 punct (,caspase
R3824 T6972 T6969 appos aCasp3,caspase
R3825 T6973 T6949 punct ),stained
R3826 T6974 T6949 cc and,stained
R3827 T6975 T6949 conj analyzed,stained
R3828 T6976 T6977 amod additional,organs
R3829 T6977 T6975 dobj organs,analyzed
R3830 T6978 T6977 cc and,organs
R3831 T6979 T6977 conj tissues,organs
R3832 T6980 T6981 advmod where,plays
R3833 T6981 T6977 relcl plays,organs
R3834 T6982 T6981 nsubj apoptosis,plays
R3835 T6983 T6984 det a,role
R3836 T6984 T6981 dobj role,plays
R3837 T6985 T6984 amod crucial,role
R3838 T6986 T6981 prep in,plays
R3839 T6987 T6988 compound tissue,remodeling
R3840 T6988 T6986 pobj remodeling,in
R3841 T6989 T6981 prep during,plays
R3842 T6990 T6989 pobj development,during
R3843 T6991 T6949 punct .,stained
R3844 T6993 T6994 advcl Starting,analyzed
R3845 T6995 T6993 prep at,Starting
R3846 T6996 T6995 pobj E12.5,at
R3847 T6997 T6994 punct ", ",analyzed
R3848 T6998 T6994 nsubj we,analyzed
R3849 T6999 T6994 cc and,analyzed
R3850 T7000 T6994 conj compared,analyzed
R3851 T7001 T7002 det the,number
R3852 T7002 T7000 dobj number,compared
R3853 T7003 T7002 cc and,number
R3854 T7004 T7002 conj distribution,number
R3855 T7005 T7002 prep of,number
R3856 T7006 T7007 npadvmod aCasp3,positive
R3857 T7007 T7009 amod positive,cells
R3858 T7008 T7007 punct -,positive
R3859 T7009 T7005 pobj cells,of
R3860 T7010 T7002 prep in,number
R3861 T7011 T7012 quantmod over,140
R3862 T7012 T7013 nummod 140,sections
R3863 T7013 T7010 pobj sections,in
R3864 T7014 T7013 amod serial,sections
R3865 T7015 T7013 prep of,sections
R3866 T7016 T7017 nummod three,type
R3867 T7017 T7015 pobj type,of
R3868 T7018 T7017 amod wild,type
R3869 T7019 T7017 punct -,type
R3870 T7020 T7017 cc and,type
R3871 T7021 T7022 nummod six,Ptdsr
R3872 T7022 T7023 nmod Ptdsr,embryos
R3873 T7023 T7017 conj embryos,type
R3874 T7024 T7022 punct -,Ptdsr
R3875 T7025 T7022 punct /,Ptdsr
R3876 T7026 T7022 punct -,Ptdsr
R3877 T7027 T7013 prep in,sections
R3878 T7028 T7029 amod consecutive,sections
R3879 T7029 T7027 pobj sections,in
R3880 T7030 T7028 cc and,consecutive
R3881 T7031 T7028 conj corresponding,consecutive
R3882 T7032 T6994 punct .,analyzed
R3883 T7034 T7035 det The,sections
R3884 T7035 T7037 nsubjpass sections,separated
R3885 T7036 T7035 amod sagittal,sections
R3886 T7038 T7037 auxpass were,separated
R3887 T7039 T7037 agent by,separated
R3888 T7040 T7041 nummod 5,μm
R3889 T7041 T7039 pobj μm,by
R3890 T7042 T7037 punct ", ",separated
R3891 T7043 T7037 advcl allowing,separated
R3892 T7044 T7045 det a,analysis
R3893 T7045 T7043 dobj analysis,allowing
R3894 T7046 T7045 amod detailed,analysis
R3895 T7047 T7045 prep of,analysis
R3896 T7048 T7047 pobj apoptosis,of
R3897 T7049 T7045 prep in,analysis
R3898 T7050 T7051 amod several,organs
R3899 T7051 T7049 pobj organs,in
R3900 T7052 T7051 cc and,organs
R3901 T7053 T7051 conj tissues,organs
R3902 T7054 T7037 punct .,separated
R3903 T7056 T7057 compound Tissue,restructuring
R3904 T7057 T7058 nsubj restructuring,occurred
R3905 T7059 T7057 prep by,restructuring
R3906 T7060 T7061 amod programmed,death
R3907 T7061 T7059 pobj death,by
R3908 T7062 T7061 compound cell,death
R3909 T7063 T7064 advmod most,notably
R3910 T7064 T7065 advmod notably,within
R3911 T7065 T7058 prep within,occurred
R3912 T7066 T7067 det the,part
R3913 T7067 T7065 pobj part,within
R3914 T7068 T7067 amod ventral,part
R3915 T7069 T7067 prep of,part
R3916 T7070 T7071 det the,tube
R3917 T7071 T7069 pobj tube,of
R3918 T7072 T7071 amod neural,tube
R3919 T7073 T7074 punct (,f
R3920 T7074 T7071 parataxis f,tube
R3921 T7075 T7074 nmod Figure,f
R3922 T7076 T7074 nmod 6b,f
R3923 T7077 T7074 punct ",",f
R3924 T7078 T7074 punct ),f
R3925 T7079 T7065 cc and,within
R3926 T7080 T7065 conj in,within
R3927 T7081 T7082 det the,ganglia
R3928 T7082 T7080 pobj ganglia,in
R3929 T7083 T7082 amod developing,ganglia
R3930 T7084 T7082 amod paravertebral,ganglia
R3931 T7085 T7086 punct (,h
R3932 T7086 T7082 parataxis h,ganglia
R3933 T7087 T7086 nmod Figure,h
R3934 T7088 T7086 nmod 6d,h
R3935 T7089 T7086 punct ",",h
R3936 T7090 T7086 punct ),h
R3937 T7091 T7058 prep with,occurred
R3938 T7092 T7093 amod many,cells
R3939 T7093 T7095 nsubj cells,being
R3940 T7094 T7093 amod apoptotic,cells
R3941 T7095 T7091 pcomp being,with
R3942 T7096 T7095 acomp present,being
R3943 T7097 T7058 punct .,occurred
R3944 T7099 T7100 prep In,is
R3945 T7101 T7102 det these,tissues
R3946 T7102 T7099 pobj tissues,In
R3947 T7103 T7100 nsubj Ptdsr,is
R3948 T7104 T7105 advmod highly,expressed
R3949 T7105 T7100 acomp expressed,is
R3950 T7106 T7100 prep at,is
R3951 T7107 T7106 pobj E12.5,at
R3952 T7108 T7109 punct (,2c
R3953 T7109 T7107 parataxis 2c,E12.5
R3954 T7110 T7109 compound Figure,2c
R3955 T7111 T7109 punct ),2c
R3956 T7112 T7100 cc but,is
R3957 T7113 T7114 nsubj we,observed
R3958 T7114 T7100 conj observed,is
R3959 T7115 T7116 det no,difference
R3960 T7116 T7114 dobj difference,observed
R3961 T7117 T7116 prep in,difference
R3962 T7118 T7119 det the,number
R3963 T7119 T7117 pobj number,in
R3964 T7120 T7119 cc or,number
R3965 T7121 T7119 conj distribution,number
R3966 T7122 T7119 prep of,number
R3967 T7123 T7124 amod apoptotic,cells
R3968 T7124 T7122 pobj cells,of
R3969 T7125 T7116 prep in,difference
R3970 T7126 T7127 nmod Ptdsr,embryos
R3971 T7127 T7125 pobj embryos,in
R3972 T7128 T7126 punct +,Ptdsr
R3973 T7129 T7126 punct /,Ptdsr
R3974 T7130 T7126 punct +,Ptdsr
R3975 T7131 T7126 cc and,Ptdsr
R3976 T7132 T7126 conj Ptdsr,Ptdsr
R3977 T7133 T7132 punct -,Ptdsr
R3978 T7134 T7132 punct /,Ptdsr
R3979 T7135 T7132 punct -,Ptdsr
R3980 T7136 T7114 punct .,observed
R3981 T7138 T7139 det The,same
R3982 T7139 T7140 nsubj same,was
R3983 T7140 T7141 ccomp was,were
R3984 T7142 T7140 acomp true,was
R3985 T7143 T7140 prep for,was
R3986 T7144 T7145 det the,kidney
R3987 T7145 T7143 pobj kidney,for
R3988 T7146 T7145 amod developing,kidney
R3989 T7147 T7141 punct : ,were
R3990 T7148 T7149 amod apoptotic,cells
R3991 T7149 T7141 nsubj cells,were
R3992 T7150 T7141 acomp present,were
R3993 T7151 T7141 prep in,were
R3994 T7152 T7153 nmod Ptdsr,embryos
R3995 T7153 T7151 pobj embryos,in
R3996 T7154 T7152 punct +,Ptdsr
R3997 T7155 T7152 punct /,Ptdsr
R3998 T7156 T7152 punct +,Ptdsr
R3999 T7157 T7152 cc and,Ptdsr
R4000 T7158 T7152 conj Ptdsr,Ptdsr
R4001 T7159 T7158 punct -,Ptdsr
R4002 T7160 T7158 punct /,Ptdsr
R4003 T7161 T7158 punct -,Ptdsr
R4004 T7162 T7141 punct ", ",were
R4005 T7163 T7141 prep in,were
R4006 T7164 T7165 amod limited,numbers
R4007 T7165 T7163 pobj numbers,in
R4008 T7166 T7141 punct ", ",were
R4009 T7167 T7141 cc but,were
R4010 T7168 T7169 nsubj we,failed
R4011 T7169 T7141 conj failed,were
R4012 T7170 T7171 aux to,detect
R4013 T7171 T7169 xcomp detect,failed
R4014 T7172 T7173 det any,differences
R4015 T7173 T7171 dobj differences,detect
R4016 T7174 T7173 prep in,differences
R4017 T7175 T7176 det the,number
R4018 T7176 T7174 pobj number,in
R4019 T7177 T7176 prep of,number
R4020 T7178 T7179 amod apoptotic,cells
R4021 T7179 T7177 pobj cells,of
R4022 T7180 T7176 prep between,number
R4023 T7181 T7182 det the,genotypes
R4024 T7182 T7180 pobj genotypes,between
R4025 T7183 T7184 punct (,6g
R4026 T7184 T7169 parataxis 6g,failed
R4027 T7185 T7184 nmod Figure,6g
R4028 T7186 T7184 nmod 6c,6g
R4029 T7187 T7184 punct ",",6g
R4030 T7188 T7184 punct ),6g
R4031 T7189 T7141 punct .,were
R4032 T7191 T7192 advmod Furthermore,was
R4033 T7193 T7192 punct ", ",was
R4034 T7194 T7195 advmod when,continued
R4035 T7195 T7192 advcl continued,was
R4036 T7196 T7195 nsubj we,continued
R4037 T7197 T7198 poss our,analysis
R4038 T7198 T7195 dobj analysis,continued
R4039 T7199 T7198 prep of,analysis
R4040 T7200 T7201 amod apoptotic,cell
R4041 T7201 T7202 compound cell,clearance
R4042 T7202 T7199 pobj clearance,of
R4043 T7203 T7204 advmod in,vivo
R4044 T7204 T7198 advmod vivo,analysis
R4045 T7205 T7195 prep at,continued
R4046 T7206 T7205 pobj E16.5,at
R4047 T7207 T7206 punct ", ",E16.5
R4048 T7208 T7206 conj E17.5,E16.5
R4049 T7209 T7208 cc and,E17.5
R4050 T7210 T7208 conj E18.5,E17.5
R4051 T7211 T7206 prep of,E16.5
R4052 T7212 T7213 amod embryonic,development
R4053 T7213 T7211 pobj development,of
R4054 T7214 T7215 advmod as,as
R4055 T7215 T7205 cc as,at
R4056 T7216 T7215 advmod well,as
R4057 T7217 T7205 conj in,at
R4058 T7218 T7219 amod neonatal,mice
R4059 T7219 T7217 pobj mice,in
R4060 T7220 T7192 punct ", ",was
R4061 T7221 T7222 det the,number
R4062 T7222 T7192 nsubj number,was
R4063 T7223 T7222 cc and,number
R4064 T7224 T7222 conj distribution,number
R4065 T7225 T7222 prep of,number
R4066 T7226 T7227 amod apoptotic,cells
R4067 T7227 T7225 pobj cells,of
R4068 T7228 T7192 acomp similar,was
R4069 T7229 T7192 prep in,was
R4070 T7230 T7231 det both,genotypes
R4071 T7231 T7229 pobj genotypes,in
R4072 T7232 T7192 punct .,was
R4073 T7234 T7235 mark As,observed
R4074 T7235 T7237 advcl observed,showed
R4075 T7236 T7235 advmod already,observed
R4076 T7238 T7235 prep at,observed
R4077 T7239 T7238 pobj E12.5,at
R4078 T7240 T7237 punct ", ",showed
R4079 T7241 T7237 nsubj analysis,showed
R4080 T7242 T7241 prep of,analysis
R4081 T7243 T7244 npadvmod aCasp3,stained
R4082 T7244 T7246 amod stained,sections
R4083 T7245 T7244 punct -,stained
R4084 T7246 T7242 pobj sections,of
R4085 T7247 T7246 prep of,sections
R4086 T7248 T7249 det the,thymus
R4087 T7249 T7247 pobj thymus,of
R4088 T7250 T7249 amod developing,thymus
R4089 T7251 T7249 punct ", ",thymus
R4090 T7252 T7249 conj heart,thymus
R4091 T7253 T7252 punct ", ",heart
R4092 T7254 T7252 conj diaphragm,heart
R4093 T7255 T7254 punct ", ",diaphragm
R4094 T7256 T7257 amod genital,ridge
R4095 T7257 T7254 conj ridge,diaphragm
R4096 T7258 T7257 punct ", ",ridge
R4097 T7259 T7257 conj eyes,ridge
R4098 T7260 T7259 cc and,eyes
R4099 T7261 T7259 conj retina,eyes
R4100 T7262 T7237 advmod convincingly,showed
R4101 T7263 T7264 mark that,was
R4102 T7264 T7237 ccomp was,showed
R4103 T7265 T7264 expl there,was
R4104 T7266 T7267 det no,impairment
R4105 T7267 T7264 attr impairment,was
R4106 T7268 T7267 prep in,impairment
R4107 T7269 T7270 amod apoptotic,removal
R4108 T7270 T7268 pobj removal,in
R4109 T7271 T7270 compound cell,removal
R4110 T7272 T7264 prep in,was
R4111 T7273 T7274 nmod Ptdsr,mice
R4112 T7274 T7272 pobj mice,in
R4113 T7275 T7273 punct -,Ptdsr
R4114 T7276 T7273 punct /,Ptdsr
R4115 T7277 T7273 punct -,Ptdsr
R4116 T7278 T7237 punct .,showed
R4117 T7280 T7281 advmod Moreover,examined
R4118 T7282 T7281 punct ", ",examined
R4119 T7283 T7284 mark because,reported
R4120 T7284 T7281 advcl reported,examined
R4121 T7285 T7284 nsubj Li,reported
R4122 T7286 T7285 cc and,Li
R4123 T7287 T7285 conj colleagues,Li
R4124 T7288 T7289 punct [,31
R4125 T7289 T7287 parataxis 31,colleagues
R4126 T7290 T7289 punct ],31
R4127 T7291 T7292 amod impaired,clearance
R4128 T7292 T7284 dobj clearance,reported
R4129 T7293 T7292 prep of,clearance
R4130 T7294 T7295 amod dead,cells
R4131 T7295 T7293 pobj cells,of
R4132 T7296 T7292 prep during,clearance
R4133 T7297 T7298 compound lung,development
R4134 T7298 T7296 pobj development,during
R4135 T7299 T7292 prep in,clearance
R4136 T7300 T7301 npadvmod Ptdsr,deficient
R4137 T7301 T7303 amod deficient,mice
R4138 T7302 T7301 punct -,deficient
R4139 T7303 T7299 pobj mice,in
R4140 T7304 T7281 punct ", ",examined
R4141 T7305 T7281 nsubj we,examined
R4142 T7306 T7307 det the,rate
R4143 T7307 T7281 dobj rate,examined
R4144 T7308 T7307 prep of,rate
R4145 T7309 T7310 compound apoptosis,induction
R4146 T7310 T7308 pobj induction,of
R4147 T7311 T7310 cc and,induction
R4148 T7312 T7313 compound cell,clearance
R4149 T7313 T7310 conj clearance,induction
R4150 T7314 T7307 prep in,rate
R4151 T7315 T7316 poss our,mice
R4152 T7316 T7314 pobj mice,in
R4153 T7317 T7318 compound Ptdsr,knockout
R4154 T7318 T7316 compound knockout,mice
R4155 T7319 T7318 punct -,knockout
R4156 T7320 T7307 prep in,rate
R4157 T7321 T7322 det the,lung
R4158 T7322 T7320 pobj lung,in
R4159 T7323 T7281 punct .,examined
R4160 T7325 T7326 nsubj Analysis,demonstrated
R4161 T7327 T7325 prep of,Analysis
R4162 T7328 T7329 npadvmod aCasp3,stained
R4163 T7329 T7331 amod stained,tissue
R4164 T7330 T7329 punct -,stained
R4165 T7331 T7327 pobj tissue,of
R4166 T7332 T7331 compound lung,tissue
R4167 T7333 T7325 prep from,Analysis
R4168 T7334 T7335 nmod Ptdsr,mice
R4169 T7335 T7333 pobj mice,from
R4170 T7336 T7334 punct +,Ptdsr
R4171 T7337 T7334 punct /,Ptdsr
R4172 T7338 T7334 punct +,Ptdsr
R4173 T7339 T7334 cc and,Ptdsr
R4174 T7340 T7334 conj Ptdsr,Ptdsr
R4175 T7341 T7340 punct -,Ptdsr
R4176 T7342 T7340 punct /,Ptdsr
R4177 T7343 T7340 punct -,Ptdsr
R4178 T7344 T7335 prep at,mice
R4179 T7345 T7344 pobj E17.5,at
R4180 T7346 T7345 cc and,E17.5
R4181 T7347 T7345 conj P0,E17.5
R4182 T7348 T7349 mark that,was
R4183 T7349 T7326 ccomp was,demonstrated
R4184 T7350 T7349 nsubj apoptosis,was
R4185 T7351 T7352 det an,event
R4186 T7352 T7349 attr event,was
R4187 T7353 T7354 advmod extremely,rare
R4188 T7354 T7352 amod rare,event
R4189 T7355 T7349 prep during,was
R4190 T7356 T7357 compound lung,morphogenesis
R4191 T7357 T7355 pobj morphogenesis,during
R4192 T7358 T7349 prep at,was
R4193 T7359 T7360 det this,stage
R4194 T7360 T7358 pobj stage,at
R4195 T7361 T7326 punct .,demonstrated
R4196 T7363 T7364 prep In,were
R4197 T7365 T7363 pobj addition,In
R4198 T7366 T7364 punct ", ",were
R4199 T7367 T7364 expl there,were
R4200 T7368 T7369 det no,differences
R4201 T7369 T7364 attr differences,were
R4202 T7370 T7369 prep in,differences
R4203 T7371 T7372 det the,number
R4204 T7372 T7370 pobj number,in
R4205 T7373 T7372 cc or,number
R4206 T7374 T7372 conj distribution,number
R4207 T7375 T7372 prep of,number
R4208 T7376 T7377 amod apoptotic,cells
R4209 T7377 T7375 pobj cells,of
R4210 T7378 T7369 prep in,differences
R4211 T7379 T7380 nmod Ptdsr,mice
R4212 T7380 T7378 pobj mice,in
R4213 T7381 T7379 punct -,Ptdsr
R4214 T7382 T7379 punct /,Ptdsr
R4215 T7383 T7379 punct -,Ptdsr
R4216 T7384 T7379 cc and,Ptdsr
R4217 T7385 T7379 conj Ptdsr,Ptdsr
R4218 T7386 T7385 punct +,Ptdsr
R4219 T7387 T7385 punct /,Ptdsr
R4220 T7388 T7385 punct +,Ptdsr
R4221 T7389 T7364 punct .,were
R4222 T7391 T7392 advmod Furthermore,were
R4223 T7393 T7392 punct ", ",were
R4224 T7394 T7392 nsubj we,were
R4225 T7395 T7392 acomp unable,were
R4226 T7396 T7397 aux to,detect
R4227 T7397 T7395 xcomp detect,unable
R4228 T7398 T7399 det any,evidence
R4229 T7399 T7397 dobj evidence,detect
R4230 T7400 T7399 prep of,evidence
R4231 T7401 T7402 compound tissue,necrosis
R4232 T7402 T7400 pobj necrosis,of
R4233 T7403 T7397 prep in,detect
R4234 T7404 T7403 pobj lungs,in
R4235 T7405 T7404 prep from,lungs
R4236 T7406 T7407 npadvmod Ptdsr,deficient
R4237 T7407 T7409 amod deficient,mice
R4238 T7408 T7407 punct -,deficient
R4239 T7409 T7405 pobj mice,from
R4240 T7410 T7392 punct .,were
R4241 T7412 T7413 prep In,observed
R4242 T7414 T7412 pobj contrast,In
R4243 T7415 T7414 prep to,contrast
R4244 T7416 T7417 det the,report
R4245 T7417 T7415 pobj report,to
R4246 T7418 T7417 prep of,report
R4247 T7419 T7418 pobj Li,of
R4248 T7420 T7421 advmod et,al.
R4249 T7421 T7419 advmod al.,Li
R4250 T7422 T7423 punct [,31
R4251 T7423 T7414 parataxis 31,contrast
R4252 T7424 T7423 punct ],31
R4253 T7425 T7413 punct ", ",observed
R4254 T7426 T7413 nsubj we,observed
R4255 T7427 T7413 neg never,observed
R4256 T7428 T7413 dobj recruitment,observed
R4257 T7429 T7428 prep of,recruitment
R4258 T7430 T7429 pobj neutrophils,of
R4259 T7431 T7428 cc or,recruitment
R4260 T7432 T7433 amod other,signs
R4261 T7433 T7428 conj signs,recruitment
R4262 T7434 T7433 prep of,signs
R4263 T7435 T7436 amod pulmonary,inflammation
R4264 T7436 T7434 pobj inflammation,of
R4265 T7437 T7413 prep at,observed
R4266 T7438 T7439 det any,stage
R4267 T7439 T7437 pobj stage,at
R4268 T7440 T7439 prep of,stage
R4269 T7441 T7440 pobj development,of
R4270 T7442 T7413 prep in,observed
R4271 T7443 T7444 poss our,mice
R4272 T7444 T7442 pobj mice,in
R4273 T7445 T7446 npadvmod Ptdsr,deficient
R4274 T7446 T7444 amod deficient,mice
R4275 T7447 T7446 punct -,deficient
R4276 T7448 T7413 punct .,observed
R4277 T7450 T7451 aux To,analyze
R4278 T7451 T7452 advcl analyze,stained
R4279 T7453 T7454 mark whether,recruited
R4280 T7454 T7451 ccomp recruited,analyze
R4281 T7455 T7454 nsubjpass macrophages,recruited
R4282 T7456 T7454 auxpass are,recruited
R4283 T7457 T7454 prep into,recruited
R4284 T7458 T7457 pobj areas,into
R4285 T7459 T7460 advmod where,is
R4286 T7460 T7458 relcl is,areas
R4287 T7461 T7460 nsubj apoptosis,is
R4288 T7462 T7460 acomp prominent,is
R4289 T7463 T7460 prep during,is
R4290 T7464 T7463 pobj embryogenesis,during
R4291 T7465 T7452 punct ", ",stained
R4292 T7466 T7452 nsubj we,stained
R4293 T7467 T7468 amod consecutive,sections
R4294 T7468 T7452 dobj sections,stained
R4295 T7469 T7468 amod serial,sections
R4296 T7470 T7471 preconj either,with
R4297 T7471 T7452 prep with,stained
R4298 T7472 T7473 det the,marker
R4299 T7473 T7471 pobj marker,with
R4300 T7474 T7473 compound macrophage,marker
R4301 T7475 T7473 compound surface,marker
R4302 T7476 T7473 appos F4,marker
R4303 T7477 T7476 punct /,F4
R4304 T7478 T7476 nummod 80,F4
R4305 T7479 T7471 cc or,with
R4306 T7480 T7471 conj with,with
R4307 T7481 T7480 pobj aCasp3,with
R4308 T7482 T7452 punct .,stained
R4309 T7484 T7485 advmod Surprisingly,was
R4310 T7486 T7485 punct ", ",was
R4311 T7487 T7485 expl there,was
R4312 T7488 T7489 det no,co-localization
R4313 T7489 T7485 attr co-localization,was
R4314 T7490 T7489 prep of,co-localization
R4315 T7491 T7490 pobj macrophages,of
R4316 T7492 T7489 prep with,co-localization
R4317 T7493 T7494 amod apoptotic,cells
R4318 T7494 T7492 pobj cells,with
R4319 T7495 T7485 punct .,was
R4320 T7497 T7498 prep In,localized
R4321 T7499 T7500 advmod virtually,tissues
R4322 T7500 T7497 pobj tissues,In
R4323 T7501 T7500 det all,tissues
R4324 T7502 T7500 amod embryonic,tissues
R4325 T7503 T7498 punct ", ",localized
R4326 T7504 T7505 amod apoptotic,cells
R4327 T7505 T7498 nsubjpass cells,localized
R4328 T7506 T7505 cc and,cells
R4329 T7507 T7505 conj macrophages,cells
R4330 T7508 T7498 auxpass were,localized
R4331 T7509 T7498 prep in,localized
R4332 T7510 T7511 amod different,compartments
R4333 T7511 T7509 pobj compartments,in
R4334 T7512 T7513 punct (,6i
R4335 T7513 T7498 parataxis 6i,localized
R4336 T7514 T7513 nmod Figure,6i
R4337 T7515 T7513 nmod 6e,6i
R4338 T7516 T7513 punct ",",6i
R4339 T7517 T7513 punct ;,6i
R4340 T7518 T7513 cc and,6i
R4341 T7519 T7513 conj see,6i
R4342 T7520 T7519 advmod also,see
R4343 T7521 T7522 amod Additional,data
R4344 T7522 T7523 compound data,file
R4345 T7523 T7519 dobj file,see
R4346 T7524 T7523 nummod 1,file
R4347 T7525 T7523 punct ", ",file
R4348 T7526 T7527 compound Figure,S1
R4349 T7527 T7523 npadvmod S1,file
R4350 T7528 T7513 punct ),6i
R4351 T7529 T7498 punct .,localized
R4352 T7531 T7532 nsubj This,suggests
R4353 T7533 T7534 mark that,is
R4354 T7534 T7532 ccomp is,suggests
R4355 T7535 T7534 prep at,is
R4356 T7536 T7537 det this,stage
R4357 T7537 T7535 pobj stage,at
R4358 T7538 T7537 prep of,stage
R4359 T7539 T7538 pobj development,of
R4360 T7540 T7534 nsubj it,is
R4361 T7541 T7534 advmod mainly,is
R4362 T7542 T7543 amod neighboring,cells
R4363 T7543 T7534 attr cells,is
R4364 T7544 T7545 dep that,involved
R4365 T7545 T7543 relcl involved,cells
R4366 T7546 T7545 auxpass are,involved
R4367 T7547 T7545 prep in,involved
R4368 T7548 T7547 pobj removal,in
R4369 T7549 T7548 prep of,removal
R4370 T7550 T7551 amod apoptotic,cells
R4371 T7551 T7549 pobj cells,of
R4372 T7552 T7543 punct ", ",cells
R4373 T7553 T7554 advmod rather,than
R4374 T7554 T7543 cc than,cells
R4375 T7555 T7556 amod professional,macrophages
R4376 T7556 T7543 conj macrophages,cells
R4377 T7557 T7532 punct .,suggests
R4378 T7559 T7560 prep In,reveal
R4379 T7561 T7559 pobj summary,In
R4380 T7562 T7560 punct ", ",reveal
R4381 T7563 T7564 poss our,analysis
R4382 T7564 T7560 nsubj analysis,reveal
R4383 T7565 T7566 advmod in,vivo
R4384 T7566 T7564 advmod vivo,analysis
R4385 T7567 T7560 aux did,reveal
R4386 T7568 T7560 neg not,reveal
R4387 T7569 T7570 det any,impairment
R4388 T7570 T7560 dobj impairment,reveal
R4389 T7571 T7560 prep in,reveal
R4390 T7572 T7573 amod apoptotic,clearance
R4391 T7573 T7571 pobj clearance,in
R4392 T7574 T7573 compound cell,clearance
R4393 T7575 T7560 prep in,reveal
R4394 T7576 T7577 npadvmod Ptdsr,deficient
R4395 T7577 T7579 amod deficient,embryos
R4396 T7578 T7577 punct -,deficient
R4397 T7579 T7575 pobj embryos,in
R4398 T7580 T7560 prep during,reveal
R4399 T7581 T7580 pobj development,during
R4400 T7582 T7560 cc and,reveal
R4401 T7583 T7584 advmod further,suggests
R4402 T7584 T7560 conj suggests,reveal
R4403 T7585 T7586 mark that,mediated
R4404 T7586 T7584 ccomp mediated,suggests
R4405 T7587 T7586 nsubjpass phagocytosis,mediated
R4406 T7588 T7587 prep of,phagocytosis
R4407 T7589 T7590 amod apoptotic,cells
R4408 T7590 T7588 pobj cells,of
R4409 T7591 T7586 auxpass is,mediated
R4410 T7592 T7586 advmod mainly,mediated
R4411 T7593 T7586 prep by,mediated
R4412 T7594 T7595 amod non-professional,cells
R4413 T7595 T7593 pobj cells,by
R4414 T7596 T7595 punct ',cells
R4415 T7597 T7595 nmod bystander,cells
R4416 T7598 T7595 punct ',cells
R4417 T7599 T7560 punct .,reveal
R4418 T7601 T7602 aux To,determine
R4419 T7602 T7603 advcl determine,performed
R4420 T7604 T7605 mark whether,impaired
R4421 T7605 T7602 ccomp impaired,determine
R4422 T7606 T7605 nsubjpass macrophages,impaired
R4423 T7607 T7606 prep from,macrophages
R4424 T7608 T7609 compound Ptdsr,knockout
R4425 T7609 T7611 compound knockout,mice
R4426 T7610 T7609 punct -,knockout
R4427 T7611 T7607 pobj mice,from
R4428 T7612 T7605 auxpass were,impaired
R4429 T7613 T7605 prep in,impaired
R4430 T7614 T7615 det the,efficacy
R4431 T7615 T7613 pobj efficacy,in
R4432 T7616 T7615 prep of,efficacy
R4433 T7617 T7618 amod apoptotic,cell
R4434 T7618 T7619 compound cell,uptake
R4435 T7619 T7616 pobj uptake,of
R4436 T7620 T7621 advmod in,vitro
R4437 T7621 T7615 advmod vitro,efficacy
R4438 T7622 T7603 punct ", ",performed
R4439 T7623 T7603 nsubj we,performed
R4440 T7624 T7625 compound phagocytosis,assays
R4441 T7625 T7603 dobj assays,performed
R4442 T7626 T7603 prep with,performed
R4443 T7627 T7628 amod fetal,liver
R4444 T7628 T7630 npadvmod liver,derived
R4445 T7629 T7628 punct -,liver
R4446 T7630 T7632 amod derived,macrophages
R4447 T7631 T7630 punct -,derived
R4448 T7632 T7626 pobj macrophages,with
R4449 T7633 T7632 punct (,macrophages
R4450 T7634 T7632 appos FLDMs,macrophages
R4451 T7635 T7603 punct ),performed
R4452 T7636 T7603 cc and,performed
R4453 T7637 T7603 conj quantified,performed
R4454 T7638 T7639 poss their,rates
R4455 T7639 T7637 dobj rates,quantified
R4456 T7640 T7639 compound phagocytosis,rates
R4457 T7641 T7603 punct .,performed
R4458 T7643 T7644 nsubjpass Phagocytosis,investigated
R4459 T7645 T7643 prep of,Phagocytosis
R4460 T7646 T7647 amod apoptotic,thymocytes
R4461 T7647 T7645 pobj thymocytes,of
R4462 T7648 T7644 auxpass was,investigated
R4463 T7649 T7644 prep at,investigated
R4464 T7650 T7651 nummod 60,minutes
R4465 T7651 T7649 pobj minutes,at
R4466 T7652 T7650 punct ", ",60
R4467 T7653 T7650 conj 90,60
R4468 T7654 T7653 cc and,90
R4469 T7655 T7653 conj 120,90
R4470 T7656 T7644 prep after,investigated
R4471 T7657 T7656 pobj addition,after
R4472 T7658 T7657 prep of,addition
R4473 T7659 T7660 compound target,cells
R4474 T7660 T7658 pobj cells,of
R4475 T7661 T7644 prep in,investigated
R4476 T7662 T7663 det the,absence
R4477 T7663 T7661 pobj absence,in
R4478 T7664 T7663 prep of,absence
R4479 T7665 T7664 pobj serum,of
R4480 T7666 T7644 punct .,investigated
R4481 T7668 T7669 nsubj Analysis,revealed
R4482 T7670 T7668 prep of,Analysis
R4483 T7671 T7672 compound phagocytosis,rates
R4484 T7672 T7670 pobj rates,of
R4485 T7673 T7668 prep by,Analysis
R4486 T7674 T7675 nmod flow,analysis
R4487 T7675 T7673 pobj analysis,by
R4488 T7676 T7675 amod cytometric,analysis
R4489 T7677 T7675 punct (,analysis
R4490 T7678 T7675 appos FACS,analysis
R4491 T7679 T7669 punct ),revealed
R4492 T7680 T7681 det no,differences
R4493 T7681 T7669 dobj differences,revealed
R4494 T7682 T7681 prep in,differences
R4495 T7683 T7684 det the,efficacy
R4496 T7684 T7682 pobj efficacy,in
R4497 T7685 T7684 prep of,efficacy
R4498 T7686 T7687 amod apoptotic,uptake
R4499 T7687 T7685 pobj uptake,of
R4500 T7688 T7687 compound cell,uptake
R4501 T7689 T7681 prep between,differences
R4502 T7690 T7691 nmod Ptdsr,macrophages
R4503 T7691 T7689 pobj macrophages,between
R4504 T7692 T7690 punct -,Ptdsr
R4505 T7693 T7690 punct /,Ptdsr
R4506 T7694 T7690 punct -,Ptdsr
R4507 T7695 T7690 cc and,Ptdsr
R4508 T7696 T7690 conj Ptdsr,Ptdsr
R4509 T7697 T7696 punct +,Ptdsr
R4510 T7698 T7696 punct /,Ptdsr
R4511 T7699 T7696 punct +,Ptdsr
R4512 T7700 T7669 cc and,revealed
R4513 T7701 T7669 conj demonstrated,revealed
R4514 T7702 T7703 det no,differences
R4515 T7703 T7701 dobj differences,demonstrated
R4516 T7704 T7703 prep in,differences
R4517 T7705 T7706 amod apoptotic,engulfment
R4518 T7706 T7704 pobj engulfment,in
R4519 T7707 T7706 compound cell,engulfment
R4520 T7708 T7703 prep between,differences
R4521 T7709 T7710 amod selected,points
R4522 T7710 T7708 pobj points,between
R4523 T7711 T7710 compound time,points
R4524 T7712 T7713 punct (,shown
R4525 T7713 T7701 parataxis shown,demonstrated
R4526 T7714 T7713 nsubj data,shown
R4527 T7715 T7713 neg not,shown
R4528 T7716 T7713 punct ),shown
R4529 T7717 T7669 punct .,revealed
R4530 T7719 T7720 aux To,re-examine
R4531 T7720 T7721 advcl re-examine,performed
R4532 T7722 T7720 cc and,re-examine
R4533 T7723 T7724 advmod further,validate
R4534 T7724 T7720 conj validate,re-examine
R4535 T7725 T7724 advmod independently,validate
R4536 T7726 T7727 det the,result
R4537 T7727 T7724 dobj result,validate
R4538 T7728 T7727 prep of,result
R4539 T7729 T7730 amod normal,uptake
R4540 T7730 T7728 pobj uptake,of
R4541 T7731 T7732 amod apoptotic,cell
R4542 T7732 T7730 compound cell,uptake
R4543 T7733 T7730 prep by,uptake
R4544 T7734 T7735 nmod Ptdsr,macrophages
R4545 T7735 T7733 pobj macrophages,by
R4546 T7736 T7734 punct -,Ptdsr
R4547 T7737 T7734 punct /,Ptdsr
R4548 T7738 T7734 punct -,Ptdsr
R4549 T7739 T7721 punct ", ",performed
R4550 T7740 T7721 nsubj we,performed
R4551 T7741 T7742 compound phagocytosis,assays
R4552 T7742 T7721 dobj assays,performed
R4553 T7743 T7721 prep for,performed
R4554 T7744 T7745 nummod 60,min
R4555 T7745 T7743 pobj min,for
R4556 T7746 T7721 cc and,performed
R4557 T7747 T7721 conj determined,performed
R4558 T7748 T7749 det the,percentage
R4559 T7749 T7747 dobj percentage,determined
R4560 T7750 T7749 prep of,percentage
R4561 T7751 T7750 pobj macrophages,of
R4562 T7752 T7753 dep that,engulfed
R4563 T7753 T7751 relcl engulfed,macrophages
R4564 T7754 T7753 aux had,engulfed
R4565 T7755 T7756 amod apoptotic,cells
R4566 T7756 T7753 dobj cells,engulfed
R4567 T7757 T7747 punct ", ",determined
R4568 T7758 T7747 prep in,determined
R4569 T7759 T7760 det a,total
R4570 T7760 T7758 pobj total,in
R4571 T7761 T7760 prep of,total
R4572 T7762 T7763 advmod at,300
R4573 T7763 T7765 nummod 300,macrophages
R4574 T7764 T7763 advmod least,300
R4575 T7765 T7761 pobj macrophages,of
R4576 T7766 T7765 acl counted,macrophages
R4577 T7767 T7766 prep by,counted
R4578 T7768 T7769 compound fluorescence,microscopy
R4579 T7769 T7767 pobj microscopy,by
R4580 T7770 T7721 punct .,performed
R4581 T7772 T7773 amod Phagocytosed,cells
R4582 T7773 T7785 nsubjpass cells,identified
R4583 T7774 T7773 punct ", ",cells
R4584 T7775 T7776 nummod 5,carboxytetramethylrhodamine
R4585 T7776 T7778 npadvmod carboxytetramethylrhodamine,labeled
R4586 T7777 T7776 punct -,carboxytetramethylrhodamine
R4587 T7778 T7773 amod labeled,cells
R4588 T7779 T7776 punct -,carboxytetramethylrhodamine
R4589 T7780 T7776 punct (,carboxytetramethylrhodamine
R4590 T7781 T7776 appos TAMRA,carboxytetramethylrhodamine
R4591 T7782 T7776 punct -,carboxytetramethylrhodamine
R4592 T7783 T7776 punct ),carboxytetramethylrhodamine
R4593 T7784 T7773 amod apoptotic,cells
R4594 T7786 T7785 auxpass were,identified
R4595 T7787 T7788 mark as,engulfed
R4596 T7788 T7785 advcl engulfed,identified
R4597 T7789 T7788 auxpass being,engulfed
R4598 T7790 T7788 prep by,engulfed
R4599 T7791 T7790 pobj inclusion,by
R4600 T7856 T7855 amod relative,number
R4601 T7792 T7791 prep in,inclusion
R4602 T7857 T7855 prep of,number
R4603 T7793 T7794 npadvmod F4,labeled
R4604 T7858 T7859 amod phagocytosed,cells
R4605 T7859 T7857 pobj cells,of
R4606 T7860 T7859 amod apoptotic,cells
R4607 T7794 T7798 amod labeled,macrophages
R4608 T7861 T7855 prep per,number
R4609 T7862 T7861 pobj macrophage,per
R4610 T7795 T7793 punct /,F4
R4611 T7863 T7864 punct (,7f
R4612 T7864 T7829 parataxis 7f,found
R4613 T7865 T7866 amod phagocytotic,index
R4614 T7796 T7793 nummod 80,F4
R4615 T7866 T7864 dep index,7f
R4616 T7867 T7864 punct ;,7f
R4617 T7797 T7794 punct -,labeled
R4618 T7868 T7864 compound Figure,7f
R4619 T7869 T7864 punct ),7f
R4620 T7870 T7829 punct .,found
R4621 T7798 T7792 pobj macrophages,in
R4622 T7872 T7873 advmod Moreover,identified
R4623 T7799 T7785 punct .,identified
R4624 T7874 T7873 punct ", ",identified
R4625 T7875 T7876 amod single,macrophages
R4626 T7801 T7802 nsubjpass Analysis,done
R4627 T7876 T7873 nsubjpass macrophages,identified
R4628 T7877 T7876 nmod Ptdsr,macrophages
R4629 T7878 T7877 punct -,Ptdsr
R4630 T7879 T7877 punct /,Ptdsr
R4631 T7803 T7802 auxpass was,done
R4632 T7880 T7877 punct -,Ptdsr
R4633 T7881 T7873 aux could,identified
R4634 T7882 T7873 auxpass be,identified
R4635 T7883 T7884 dep that,engulfed
R4636 T7804 T7802 advmod independently,done
R4637 T7805 T7802 agent by,done
R4638 T7884 T7873 ccomp engulfed,identified
R4639 T7885 T7884 aux had,engulfed
R4640 T7886 T7887 advmod even,more
R4641 T7887 T7888 amod more,cells
R4642 T7806 T7807 nummod three,investigators
R4643 T7888 T7884 dobj cells,engulfed
R4644 T7889 T7888 amod apoptotic,cells
R4645 T7890 T7888 compound target,cells
R4646 T7891 T7892 mark than,had
R4647 T7892 T7888 advcl had,cells
R4648 T7807 T7805 pobj investigators,by
R4649 T7893 T7894 amod wild,type
R4650 T7894 T7896 compound type,macrophages
R4651 T7808 T7809 dep who,were
R4652 T7895 T7894 punct -,type
R4653 T7896 T7892 nsubj macrophages,had
R4654 T7809 T7807 relcl were,investigators
R4655 T7897 T7898 punct (,d
R4656 T7898 T7873 parataxis d,identified
R4657 T7899 T7898 nmod Figure,d
R4658 T7810 T7809 neg not,were
R4659 T7900 T7898 nmod 7b,d
R4660 T7901 T7898 punct ",",d
R4661 T7902 T7898 punct ),d
R4662 T7811 T7809 acomp aware,were
R4663 T7903 T7873 punct .,identified
R4664 T7812 T7811 prep of,aware
R4665 T7905 T7906 advmod Thus,had
R4666 T7907 T7906 punct ", ",had
R4667 T7813 T7814 compound macrophage,genotypes
R4668 T7908 T7909 npadvmod Ptdsr,deficient
R4669 T7909 T7911 amod deficient,macrophages
R4670 T7910 T7909 punct -,deficient
R4671 T7911 T7906 nsubj macrophages,had
R4672 T7814 T7812 pobj genotypes,of
R4673 T7912 T7913 det a,ability
R4674 T7913 T7906 dobj ability,had
R4675 T7815 T7816 punct (,Ptdsr
R4676 T7914 T7913 amod normal,ability
R4677 T7915 T7916 aux to,ingest
R4678 T7916 T7913 acl ingest,ability
R4679 T7917 T7918 amod apoptotic,cells
R4680 T7816 T7814 parataxis Ptdsr,genotypes
R4681 T7918 T7916 dobj cells,ingest
R4682 T7919 T7906 cc and,had
R4683 T7817 T7816 punct -,Ptdsr
R4684 T7920 T7921 auxpass were,impaired
R4685 T7921 T7906 conj impaired,had
R4686 T7922 T7921 neg not,impaired
R4687 T7818 T7816 punct /,Ptdsr
R4688 T7923 T7921 prep in,impaired
R4689 T7924 T7923 pobj recognition,in
R4690 T7925 T7924 cc or,recognition
R4691 T7926 T7924 conj phagocytosis,recognition
R4692 T7927 T7924 prep of,recognition
R4693 T7928 T7927 pobj cells,of
R4694 T7819 T7816 punct -,Ptdsr
R4695 T7929 T7930 dep that,undergone
R4696 T7930 T7928 relcl undergone,cells
R4697 T7820 T7816 cc or,Ptdsr
R4698 T7931 T7930 aux had,undergone
R4699 T7932 T7933 amod programmed,death
R4700 T7933 T7930 dobj death,undergone
R4701 T7821 T7816 conj Ptdsr,Ptdsr
R4702 T7934 T7933 compound cell,death
R4703 T7935 T7906 punct .,had
R4704 T7822 T7821 punct +,Ptdsr
R4705 T7823 T7821 punct /,Ptdsr
R4706 T7824 T7821 punct +,Ptdsr
R4707 T7825 T7816 punct ),Ptdsr
R4708 T7826 T7802 punct .,done
R4709 T7828 T7829 advmod Again,found
R4710 T7830 T7829 punct ", ",found
R4711 T7831 T7832 det no,differences
R4712 T7832 T7829 nsubjpass differences,found
R4713 T7833 T7829 auxpass were,found
R4714 T7834 T7829 prep in,found
R4715 T7835 T7836 det the,percentage
R4716 T7836 T7834 pobj percentage,in
R4717 T7837 T7836 prep of,percentage
R4718 T7838 T7837 pobj macrophages,of
R4719 T7839 T7840 dep that,engulfed
R4720 T7840 T7838 relcl engulfed,macrophages
R4721 T7841 T7840 aux had,engulfed
R4722 T7842 T7843 amod apoptotic,cells
R4723 T7843 T7840 dobj cells,engulfed
R4724 T7844 T7845 punct (,e
R4725 T7845 T7840 parataxis e,engulfed
R4726 T7846 T7845 nmod Figure,e
R4727 T7847 T7845 nmod 7a,e
R4728 T7848 T7845 punct ",",e
R4729 T7849 T7845 nmod c,e
R4730 T7850 T7845 punct ",",e
R4731 T7851 T7845 punct ),e
R4732 T7852 T7834 cc or,in
R4733 T7853 T7834 conj in,in
R4734 T7854 T7855 det the,number
R4735 T7855 T7853 pobj number,in