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PMC:548520 / 6471-7491 JSONTXT 5 Projects

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Id Subject Object Predicate Lexical cue
T2373 0-1 DT denotes A
T2375 2-10 JJ denotes standard
T2376 11-16 VB denotes knock
T2377 16-17 HYPH denotes -
T2378 17-20 RP denotes out
T2374 21-29 NN denotes protocol
T2380 30-33 VBD denotes was
T2379 34-38 VBN denotes used
T2381 39-41 TO denotes to
T2382 42-50 VB denotes generate
T2383 51-55 NNS denotes mice
T2384 56-58 IN denotes in
T2386 59-64 WDT denotes which
T2387 65-68 DT denotes the
T2388 69-80 NN denotes homeodomain
T2389 81-83 IN denotes of
T2390 84-87 NN denotes Crx
T2391 87-88 SYM denotes -
T2392 88-89 HYPH denotes /
T2393 89-90 SYM denotes -
T2394 91-94 VBD denotes was
T2385 95-103 VBN denotes targeted
T2395 104-107 CC denotes and
T2396 108-115 VBN denotes deleted
T2397 115-116 . denotes .
T2398 116-182 sentence denotes Generation of these Crx-/- mice has been reported elsewhere [34].
T2399 117-127 NN denotes Generation
T2401 128-130 IN denotes of
T2402 131-136 DT denotes these
T2404 137-140 NN denotes Crx
T2405 140-141 SYM denotes -
T2406 141-142 HYPH denotes /
T2407 142-143 SYM denotes -
T2403 144-148 NNS denotes mice
T2408 149-152 VBZ denotes has
T2409 153-157 VBN denotes been
T2400 158-166 VBN denotes reported
T2410 167-176 RB denotes elsewhere
T2411 177-178 -LRB- denotes [
T2412 178-180 CD denotes 34
T2413 180-181 -RRB- denotes ]
T2414 181-182 . denotes .
T2415 182-367 sentence denotes In this study, in order to characterize further the role of Crx in photoreceptor morphogenesis, the outer retinae from Crx-/- mice were examined using transmission electron microscopy.
T2416 183-185 IN denotes In
T2418 186-190 DT denotes this
T2419 191-196 NN denotes study
T2420 196-198 , denotes ,
T2421 198-200 IN denotes in
T2422 201-206 NN denotes order
T2423 207-209 TO denotes to
T2424 210-222 VB denotes characterize
T2425 223-230 RB denotes further
T2426 231-234 DT denotes the
T2427 235-239 NN denotes role
T2428 240-242 IN denotes of
T2429 243-246 NN denotes Crx
T2430 247-249 IN denotes in
T2431 250-263 NN denotes photoreceptor
T2432 264-277 NN denotes morphogenesis
T2433 277-279 , denotes ,
T2434 279-282 DT denotes the
T2436 283-288 JJ denotes outer
T2435 289-296 NNS denotes retinae
T2437 297-301 IN denotes from
T2438 302-305 NN denotes Crx
T2440 305-306 SYM denotes -
T2441 306-307 HYPH denotes /
T2442 307-308 SYM denotes -
T2439 309-313 NNS denotes mice
T2443 314-318 VBD denotes were
T2417 319-327 VBN denotes examined
T2444 328-333 VBG denotes using
T2445 334-346 NN denotes transmission
T2447 347-355 NN denotes electron
T2446 356-366 NN denotes microscopy
T2448 366-367 . denotes .
T2449 367-546 sentence denotes At postnatal day 21 (P21), when Crx+/+ photoreceptors exhibited robust outer segments (Figure 1A, os), Crx-/- retinas were without a recognizable outer segment layer (Figure 1B).
T2450 368-370 IN denotes At
T2452 371-380 JJ denotes postnatal
T2453 381-384 NN denotes day
T2454 385-387 CD denotes 21
T2455 388-389 -LRB- denotes (
T2456 389-392 NN denotes P21
T2457 392-393 -RRB- denotes )
T2458 393-395 , denotes ,
T2459 395-399 WRB denotes when
T2461 400-403 NN denotes Crx
T2463 403-404 SYM denotes +
T2464 404-405 HYPH denotes /
T2465 405-406 SYM denotes +
T2462 407-421 NNS denotes photoreceptors
T2460 422-431 VBD denotes exhibited
T2466 432-438 JJ denotes robust
T2468 439-444 JJ denotes outer
T2467 445-453 NNS denotes segments
T2469 454-455 -LRB- denotes (
T2471 455-461 NN denotes Figure
T2472 462-464 NN denotes 1A
T2473 464-466 , denotes ,
T2470 466-468 NN denotes os
T2474 468-469 -RRB- denotes )
T2475 469-471 , denotes ,
T2476 471-474 NN denotes Crx
T2478 474-475 SYM denotes -
T2479 475-476 HYPH denotes /
T2480 476-477 SYM denotes -
T2477 478-485 NNS denotes retinas
T2451 486-490 VBD denotes were
T2481 491-498 IN denotes without
T2482 499-500 DT denotes a
T2484 501-513 JJ denotes recognizable
T2485 514-519 JJ denotes outer
T2486 520-527 NN denotes segment
T2483 528-533 NN denotes layer
T2487 534-535 -LRB- denotes (
T2488 535-541 NN denotes Figure
T2489 542-544 CD denotes 1B
T2490 544-545 -RRB- denotes )
T2491 545-546 . denotes .
T2492 546-721 sentence denotes Crx-/- photoreceptors had inner segments, demonstrating at least limited photoreceptor polarization in the Crx mutant, but the inner segments were extremely short (Figure 2).
T2493 547-550 NN denotes Crx
T2495 550-551 SYM denotes -
T2496 551-552 HYPH denotes /
T2497 552-553 SYM denotes -
T2494 554-568 NNS denotes photoreceptors
T2498 569-572 VBD denotes had
T2499 573-578 JJ denotes inner
T2500 579-587 NNS denotes segments
T2501 587-589 , denotes ,
T2502 589-602 VBG denotes demonstrating
T2503 603-605 RB denotes at
T2504 606-611 RBS denotes least
T2505 612-619 JJ denotes limited
T2507 620-633 NN denotes photoreceptor
T2506 634-646 NN denotes polarization
T2508 647-649 IN denotes in
T2509 650-653 DT denotes the
T2511 654-657 NN denotes Crx
T2510 658-664 NN denotes mutant
T2512 664-666 , denotes ,
T2513 666-669 CC denotes but
T2514 670-673 DT denotes the
T2516 674-679 JJ denotes inner
T2515 680-688 NNS denotes segments
T2517 689-693 VBD denotes were
T2518 694-703 RB denotes extremely
T2519 704-709 JJ denotes short
T2520 710-711 -LRB- denotes (
T2521 711-717 NN denotes Figure
T2522 718-719 CD denotes 2
T2523 719-720 -RRB- denotes )
T2524 720-721 . denotes .
T2525 721-883 sentence denotes Furthermore, the majority of inner segments showed some morphological differentiation, having approximately as many mitochondria as the control (Figure 1 and 2).
T2526 722-733 RB denotes Furthermore
T2528 733-735 , denotes ,
T2529 735-738 DT denotes the
T2530 739-747 NN denotes majority
T2531 748-750 IN denotes of
T2532 751-756 JJ denotes inner
T2533 757-765 NNS denotes segments
T2527 766-772 VBD denotes showed
T2534 773-777 DT denotes some
T2536 778-791 JJ denotes morphological
T2535 792-807 NN denotes differentiation
T2537 807-809 , denotes ,
T2538 809-815 VBG denotes having
T2539 816-829 RB denotes approximately
T2541 830-832 RB denotes as
T2540 833-837 JJ denotes many
T2542 838-850 NNS denotes mitochondria
T2543 851-853 IN denotes as
T2544 854-857 DT denotes the
T2545 858-865 NN denotes control
T2546 866-867 -LRB- denotes (
T2548 867-873 NN denotes Figure
T2547 874-875 CD denotes 1
T2549 876-879 CC denotes and
T2550 880-881 CD denotes 2
T2551 881-882 -RRB- denotes )
T2552 882-883 . denotes .
T2553 883-1020 sentence denotes Occasionally, an inner segment undergoing lysis was noted, appearing swollen or with vacuoles and swollen mitochondria (data not shown).
T2554 884-896 RB denotes Occasionally
T2556 896-898 , denotes ,
T2557 898-900 DT denotes an
T2559 901-906 JJ denotes inner
T2558 907-914 NN denotes segment
T2560 915-925 VBG denotes undergoing
T2561 926-931 NN denotes lysis
T2562 932-935 VBD denotes was
T2555 936-941 VBN denotes noted
T2563 941-943 , denotes ,
T2564 943-952 VBG denotes appearing
T2565 953-960 VBN denotes swollen
T2566 961-963 CC denotes or
T2567 964-968 IN denotes with
T2568 969-977 NNS denotes vacuoles
T2569 978-981 CC denotes and
T2570 982-989 VBN denotes swollen
T2571 990-1002 NNS denotes mitochondria
T2572 1003-1004 -LRB- denotes (
T2574 1004-1008 NNS denotes data
T2575 1009-1012 RB denotes not
T2573 1013-1018 VBN denotes shown
T2576 1018-1019 -RRB- denotes )
T2577 1019-1020 . denotes .
R1156 T2373 T2374 det A,protocol
R1157 T2374 T2379 nsubjpass protocol,used
R1158 T2375 T2374 amod standard,protocol
R1159 T2376 T2374 amod knock,protocol
R1160 T2377 T2376 punct -,knock
R1161 T2378 T2376 prt out,knock
R1162 T2380 T2379 auxpass was,used
R1163 T2381 T2382 aux to,generate
R1164 T2382 T2379 advcl generate,used
R1165 T2383 T2382 dobj mice,generate
R1166 T2384 T2385 prep in,targeted
R1167 T2385 T2383 relcl targeted,mice
R1168 T2386 T2384 pobj which,in
R1169 T2387 T2388 det the,homeodomain
R1170 T2388 T2385 nsubjpass homeodomain,targeted
R1171 T2389 T2388 prep of,homeodomain
R1172 T2390 T2389 pobj Crx,of
R1173 T2391 T2390 punct -,Crx
R1174 T2392 T2390 punct /,Crx
R1175 T2393 T2390 punct -,Crx
R1176 T2394 T2385 auxpass was,targeted
R1177 T2395 T2385 cc and,targeted
R1178 T2396 T2385 conj deleted,targeted
R1179 T2397 T2379 punct .,used
R1180 T2399 T2400 nsubjpass Generation,reported
R1181 T2401 T2399 prep of,Generation
R1182 T2402 T2403 det these,mice
R1183 T2403 T2401 pobj mice,of
R1184 T2404 T2403 nmod Crx,mice
R1185 T2405 T2404 punct -,Crx
R1186 T2406 T2404 punct /,Crx
R1187 T2407 T2404 punct -,Crx
R1188 T2408 T2400 aux has,reported
R1189 T2409 T2400 auxpass been,reported
R1190 T2410 T2400 advmod elsewhere,reported
R1191 T2411 T2412 punct [,34
R1192 T2412 T2400 parataxis 34,reported
R1193 T2413 T2412 punct ],34
R1194 T2414 T2400 punct .,reported
R1195 T2416 T2417 prep In,examined
R1196 T2418 T2419 det this,study
R1197 T2419 T2416 pobj study,In
R1198 T2420 T2417 punct ", ",examined
R1199 T2421 T2417 prep in,examined
R1200 T2422 T2421 pobj order,in
R1201 T2423 T2424 aux to,characterize
R1202 T2424 T2422 acl characterize,order
R1203 T2425 T2424 advmod further,characterize
R1204 T2426 T2427 det the,role
R1205 T2427 T2424 dobj role,characterize
R1206 T2428 T2427 prep of,role
R1207 T2429 T2428 pobj Crx,of
R1208 T2430 T2427 prep in,role
R1209 T2431 T2432 compound photoreceptor,morphogenesis
R1210 T2432 T2430 pobj morphogenesis,in
R1211 T2433 T2417 punct ", ",examined
R1212 T2434 T2435 det the,retinae
R1213 T2435 T2417 nsubjpass retinae,examined
R1214 T2436 T2435 amod outer,retinae
R1215 T2437 T2435 prep from,retinae
R1216 T2438 T2439 nmod Crx,mice
R1217 T2439 T2437 pobj mice,from
R1218 T2440 T2438 punct -,Crx
R1219 T2441 T2438 punct /,Crx
R1220 T2442 T2438 punct -,Crx
R1221 T2443 T2417 auxpass were,examined
R1222 T2444 T2417 advcl using,examined
R1223 T2445 T2446 compound transmission,microscopy
R1224 T2446 T2444 dobj microscopy,using
R1225 T2447 T2446 compound electron,microscopy
R1226 T2448 T2417 punct .,examined
R1227 T2450 T2451 prep At,were
R1228 T2452 T2453 amod postnatal,day
R1229 T2453 T2450 pobj day,At
R1230 T2454 T2453 nummod 21,day
R1231 T2455 T2453 punct (,day
R1232 T2456 T2453 appos P21,day
R1233 T2457 T2451 punct ),were
R1234 T2458 T2451 punct ", ",were
R1235 T2459 T2460 advmod when,exhibited
R1236 T2460 T2451 advcl exhibited,were
R1237 T2461 T2462 nmod Crx,photoreceptors
R1238 T2462 T2460 nsubj photoreceptors,exhibited
R1239 T2463 T2461 punct +,Crx
R1240 T2464 T2461 punct /,Crx
R1241 T2465 T2461 punct +,Crx
R1242 T2466 T2467 amod robust,segments
R1243 T2467 T2460 dobj segments,exhibited
R1244 T2468 T2467 amod outer,segments
R1245 T2469 T2470 punct (,os
R1246 T2470 T2460 parataxis os,exhibited
R1247 T2471 T2472 compound Figure,1A
R1248 T2472 T2470 dep 1A,os
R1249 T2473 T2470 punct ", ",os
R1250 T2474 T2470 punct ),os
R1251 T2475 T2451 punct ", ",were
R1252 T2476 T2477 nmod Crx,retinas
R1253 T2477 T2451 nsubj retinas,were
R1254 T2478 T2476 punct -,Crx
R1255 T2479 T2476 punct /,Crx
R1256 T2480 T2476 punct -,Crx
R1257 T2481 T2451 prep without,were
R1258 T2482 T2483 det a,layer
R1259 T2483 T2481 pobj layer,without
R1260 T2484 T2483 amod recognizable,layer
R1261 T2485 T2486 amod outer,segment
R1262 T2486 T2483 compound segment,layer
R1263 T2487 T2488 punct (,Figure
R1264 T2488 T2451 parataxis Figure,were
R1265 T2489 T2488 nummod 1B,Figure
R1266 T2490 T2488 punct ),Figure
R1267 T2491 T2451 punct .,were
R1268 T2493 T2494 nmod Crx,photoreceptors
R1269 T2494 T2498 nsubj photoreceptors,had
R1270 T2495 T2493 punct -,Crx
R1271 T2496 T2493 punct /,Crx
R1272 T2497 T2493 punct -,Crx
R1273 T2499 T2500 amod inner,segments
R1274 T2500 T2498 dobj segments,had
R1275 T2501 T2498 punct ", ",had
R1276 T2502 T2498 advcl demonstrating,had
R1277 T2503 T2504 advmod at,least
R1278 T2504 T2505 advmod least,limited
R1279 T2505 T2506 amod limited,polarization
R1280 T2506 T2502 dobj polarization,demonstrating
R1281 T2507 T2506 compound photoreceptor,polarization
R1282 T2508 T2506 prep in,polarization
R1283 T2509 T2510 det the,mutant
R1284 T2510 T2508 pobj mutant,in
R1285 T2511 T2510 compound Crx,mutant
R1286 T2512 T2498 punct ", ",had
R1287 T2513 T2498 cc but,had
R1288 T2514 T2515 det the,segments
R1289 T2515 T2517 nsubj segments,were
R1290 T2516 T2515 amod inner,segments
R1291 T2517 T2498 conj were,had
R1292 T2518 T2519 advmod extremely,short
R1293 T2519 T2517 acomp short,were
R1294 T2520 T2521 punct (,Figure
R1295 T2521 T2517 parataxis Figure,were
R1296 T2522 T2521 nummod 2,Figure
R1297 T2523 T2521 punct ),Figure
R1298 T2524 T2517 punct .,were
R1299 T2526 T2527 advmod Furthermore,showed
R1300 T2528 T2527 punct ", ",showed
R1301 T2529 T2530 det the,majority
R1302 T2530 T2527 nsubj majority,showed
R1303 T2531 T2530 prep of,majority
R1304 T2532 T2533 amod inner,segments
R1305 T2533 T2531 pobj segments,of
R1306 T2534 T2535 det some,differentiation
R1307 T2535 T2527 dobj differentiation,showed
R1308 T2536 T2535 amod morphological,differentiation
R1309 T2537 T2527 punct ", ",showed
R1310 T2538 T2527 advcl having,showed
R1311 T2539 T2540 advmod approximately,many
R1312 T2540 T2542 amod many,mitochondria
R1313 T2541 T2540 advmod as,many
R1314 T2542 T2538 dobj mitochondria,having
R1315 T2543 T2542 prep as,mitochondria
R1316 T2544 T2545 det the,control
R1317 T2545 T2543 pobj control,as
R1318 T2546 T2547 punct (,1
R1319 T2547 T2538 parataxis 1,having
R1320 T2548 T2547 nmod Figure,1
R1321 T2549 T2547 cc and,1
R1322 T2550 T2547 conj 2,1
R1323 T2551 T2547 punct ),1
R1324 T2552 T2527 punct .,showed
R1325 T2554 T2555 advmod Occasionally,noted
R1326 T2556 T2555 punct ", ",noted
R1327 T2557 T2558 det an,segment
R1328 T2558 T2555 nsubjpass segment,noted
R1329 T2559 T2558 amod inner,segment
R1330 T2560 T2558 acl undergoing,segment
R1331 T2561 T2560 dobj lysis,undergoing
R1332 T2562 T2555 auxpass was,noted
R1333 T2563 T2555 punct ", ",noted
R1334 T2564 T2555 advcl appearing,noted
R1335 T2565 T2564 oprd swollen,appearing
R1336 T2566 T2565 cc or,swollen
R1337 T2567 T2565 conj with,swollen
R1338 T2568 T2567 pobj vacuoles,with
R1339 T2569 T2568 cc and,vacuoles
R1340 T2570 T2571 amod swollen,mitochondria
R1341 T2571 T2568 conj mitochondria,vacuoles
R1342 T2572 T2573 punct (,shown
R1343 T2573 T2564 parataxis shown,appearing
R1344 T2574 T2573 nsubj data,shown
R1345 T2575 T2573 neg not,shown
R1346 T2576 T2573 punct ),shown
R1347 T2577 T2555 punct .,noted