PMC:548520 JSON TXT 8 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id	Subject	Object	Predicate	Lexical cue
T115	0-14	NN	denotes	Synaptogenesis
T117	0-96	sentence	denotes	Synaptogenesis and outer segment formation are perturbed in the neural retina of Crx mutant mice
T118	15-18	CC	denotes	and
T119	19-24	JJ	denotes	outer
T120	25-32	NN	denotes	segment
T121	33-42	NN	denotes	formation
T122	43-46	VBP	denotes	are
T116	47-56	VBN	denotes	perturbed
T123	57-59	IN	denotes	in
T124	60-63	DT	denotes	the
T126	64-70	JJ	denotes	neural
T125	71-77	NN	denotes	retina
T127	78-80	IN	denotes	of
T128	81-84	NN	denotes	Crx
T130	85-91	NN	denotes	mutant
T129	92-96	NNS	denotes	mice
T131	96-97	sentence	denotes
T132	107-117	sentence	denotes	Background
T133	107-117	NN	denotes	Background
T134	117-214	sentence	denotes	In Leber's congenital amaurosis (LCA), affected individuals are blind, or nearly so, from birth.
T135	118-120	IN	denotes	In
T137	121-126	NNP	denotes	Leber
T139	126-128	POS	denotes	's
T140	129-139	JJ	denotes	congenital
T138	140-149	NN	denotes	amaurosis
T141	150-151	-LRB-	denotes	(
T142	151-154	NN	denotes	LCA
T143	154-155	-RRB-	denotes	)
T144	155-157	,	denotes	,
T145	157-165	VBN	denotes	affected
T146	166-177	NNS	denotes	individuals
T136	178-181	VBP	denotes	are
T147	182-187	JJ	denotes	blind
T148	187-189	,	denotes	,
T149	189-191	CC	denotes	or
T150	192-198	RB	denotes	nearly
T151	199-201	RB	denotes	so
T152	201-203	,	denotes	,
T153	203-207	IN	denotes	from
T154	208-213	NN	denotes	birth
T155	213-214	.	denotes	.
T156	214-283	sentence	denotes	This early onset suggests abnormal development of the neural retina.
T157	215-219	DT	denotes	This
T159	220-225	JJ	denotes	early
T158	226-231	NN	denotes	onset
T160	232-240	VBZ	denotes	suggests
T161	241-249	JJ	denotes	abnormal
T162	250-261	NN	denotes	development
T163	262-264	IN	denotes	of
T164	265-268	DT	denotes	the
T166	269-275	JJ	denotes	neural
T165	276-282	NN	denotes	retina
T167	282-283	.	denotes	.
T168	283-421	sentence	denotes	Mutations in genes that affect the development and/or function of photoreceptor cells have been found to be responsible in some families.
T169	284-293	NNS	denotes	Mutations
T171	294-296	IN	denotes	in
T172	297-302	NNS	denotes	genes
T173	303-307	WDT	denotes	that
T174	308-314	VBP	denotes	affect
T175	315-318	DT	denotes	the
T176	319-330	NN	denotes	development
T177	331-334	CC	denotes	and
T178	334-335	HYPH	denotes	/
T179	335-337	CC	denotes	or
T180	338-346	NN	denotes	function
T181	347-349	IN	denotes	of
T182	350-363	NN	denotes	photoreceptor
T183	364-369	NNS	denotes	cells
T184	370-374	VBP	denotes	have
T185	375-379	VBN	denotes	been
T170	380-385	VBN	denotes	found
T186	386-388	TO	denotes	to
T187	389-391	VB	denotes	be
T188	392-403	JJ	denotes	responsible
T189	404-406	IN	denotes	in
T190	407-411	DT	denotes	some
T191	412-420	NNS	denotes	families
T192	420-421	.	denotes	.
T193	421-502	sentence	denotes	These examples include mutations in the photoreceptor transcription factor, Crx.
T194	422-427	DT	denotes	These
T195	428-436	NNS	denotes	examples
T196	437-444	VBP	denotes	include
T197	445-454	NNS	denotes	mutations
T198	455-457	IN	denotes	in
T199	458-461	DT	denotes	the
T201	462-475	NN	denotes	photoreceptor
T202	476-489	NN	denotes	transcription
T200	490-496	NN	denotes	factor
T203	496-498	,	denotes	,
T204	498-501	NN	denotes	Crx
T205	501-502	.	denotes	.
T206	502-511	sentence	denotes	Results
T207	504-511	NNS	denotes	Results
T208	511-628	sentence	denotes	A Crx mutant strain of mice was created to serve as a model for LCA and to provide more insight into Crx's function.
T209	512-513	DT	denotes	A
T211	514-517	NN	denotes	Crx
T212	518-524	JJ	denotes	mutant
T210	525-531	NN	denotes	strain
T214	532-534	IN	denotes	of
T215	535-539	NNS	denotes	mice
T216	540-543	VBD	denotes	was
T213	544-551	VBN	denotes	created
T217	552-554	TO	denotes	to
T218	555-560	VB	denotes	serve
T219	561-563	IN	denotes	as
T220	564-565	DT	denotes	a
T221	566-571	NN	denotes	model
T222	572-575	IN	denotes	for
T223	576-579	NN	denotes	LCA
T224	580-583	CC	denotes	and
T225	584-586	TO	denotes	to
T226	587-594	VB	denotes	provide
T227	595-599	JJR	denotes	more
T228	600-607	NN	denotes	insight
T229	608-612	IN	denotes	into
T230	613-616	NN	denotes	Crx
T232	616-618	POS	denotes	's
T231	619-627	NN	denotes	function
T233	627-628	.	denotes	.
T234	628-730	sentence	denotes	In this study, an ultrastructural analysis of the developing retina in Crx mutant mice was performed.
T235	629-631	IN	denotes	In
T237	632-636	DT	denotes	this
T238	637-642	NN	denotes	study
T239	642-644	,	denotes	,
T240	644-646	DT	denotes	an
T242	647-662	JJ	denotes	ultrastructural
T241	663-671	NN	denotes	analysis
T243	672-674	IN	denotes	of
T244	675-678	DT	denotes	the
T246	679-689	VBG	denotes	developing
T245	690-696	NN	denotes	retina
T247	697-699	IN	denotes	in
T248	700-703	NN	denotes	Crx
T250	704-710	NN	denotes	mutant
T249	711-715	NNS	denotes	mice
T251	716-719	VBD	denotes	was
T236	720-729	VBN	denotes	performed
T252	729-730	.	denotes	.
T253	730-878	sentence	denotes	Outer segment morphogenesis was found to be blocked at the elongation stage, leading to a failure in production of the phototransduction apparatus.
T254	731-736	JJ	denotes	Outer
T256	737-744	NN	denotes	segment
T255	745-758	NN	denotes	morphogenesis
T258	759-762	VBD	denotes	was
T257	763-768	VBN	denotes	found
T259	769-771	TO	denotes	to
T261	772-774	VB	denotes	be
T260	775-782	VBN	denotes	blocked
T262	783-785	IN	denotes	at
T263	786-789	DT	denotes	the
T265	790-800	NN	denotes	elongation
T264	801-806	NN	denotes	stage
T266	806-808	,	denotes	,
T267	808-815	VBG	denotes	leading
T268	816-818	IN	denotes	to
T269	819-820	DT	denotes	a
T270	821-828	NN	denotes	failure
T271	829-831	IN	denotes	in
T272	832-842	NN	denotes	production
T273	843-845	IN	denotes	of
T274	846-849	DT	denotes	the
T276	850-867	NN	denotes	phototransduction
T275	868-877	NN	denotes	apparatus
T277	877-878	.	denotes	.
T278	878-987	sentence	denotes	Further, Crx-/- photoreceptors demonstrated severely abnormal synaptic endings in the outer plexiform layer.
T279	879-886	RB	denotes	Further
T281	886-888	,	denotes	,
T282	888-891	NN	denotes	Crx
T284	891-892	SYM	denotes	-
T285	892-893	HYPH	denotes	/
T286	893-894	SYM	denotes	-
T283	895-909	NNS	denotes	photoreceptors
T280	910-922	VBD	denotes	demonstrated
T287	923-931	RB	denotes	severely
T288	932-940	JJ	denotes	abnormal
T290	941-949	JJ	denotes	synaptic
T289	950-957	NNS	denotes	endings
T291	958-960	IN	denotes	in
T292	961-964	DT	denotes	the
T294	965-970	JJ	denotes	outer
T295	971-980	NN	denotes	plexiform
T293	981-986	NN	denotes	layer
T296	986-987	.	denotes	.
T297	987-1000	sentence	denotes	Conclusions
T298	989-1000	NNS	denotes	Conclusions
T299	1000-1080	sentence	denotes	This is the first report of a synaptogenesis defect in an animal model for LCA.
T300	1001-1005	DT	denotes	This
T301	1006-1008	VBZ	denotes	is
T302	1009-1012	DT	denotes	the
T304	1013-1018	JJ	denotes	first
T303	1019-1025	NN	denotes	report
T305	1026-1028	IN	denotes	of
T306	1029-1030	DT	denotes	a
T308	1031-1045	NN	denotes	synaptogenesis
T307	1046-1052	NN	denotes	defect
T309	1053-1055	IN	denotes	in
T310	1056-1058	DT	denotes	an
T312	1059-1065	NN	denotes	animal
T311	1066-1071	NN	denotes	model
T313	1072-1075	IN	denotes	for
T314	1076-1079	NN	denotes	LCA
T315	1079-1080	.	denotes	.
T316	1080-1243	sentence	denotes	These data confirm the essential role this gene plays in multiple aspects of photoreceptor development and extend our understanding of the basic pathology of LCA.
T317	1081-1086	DT	denotes	These
T318	1087-1091	NNS	denotes	data
T319	1092-1099	VBP	denotes	confirm
T320	1100-1103	DT	denotes	the
T322	1104-1113	JJ	denotes	essential
T321	1114-1118	NN	denotes	role
T323	1119-1123	DT	denotes	this
T324	1124-1128	NN	denotes	gene
T325	1129-1134	VBZ	denotes	plays
T326	1135-1137	IN	denotes	in
T327	1138-1146	JJ	denotes	multiple
T328	1147-1154	NNS	denotes	aspects
T329	1155-1157	IN	denotes	of
T330	1158-1171	NN	denotes	photoreceptor
T331	1172-1183	NN	denotes	development
T332	1184-1187	CC	denotes	and
T333	1188-1194	VBP	denotes	extend
T334	1195-1198	PRP$	denotes	our
T335	1199-1212	NN	denotes	understanding
T336	1213-1215	IN	denotes	of
T337	1216-1219	DT	denotes	the
T339	1220-1225	JJ	denotes	basic
T338	1226-1235	NN	denotes	pathology
T340	1236-1238	IN	denotes	of
T341	1239-1242	NN	denotes	LCA
T342	1242-1243	.	denotes	.
T822	1256-1269	NN	denotes	Photoreceptor
T823	1270-1275	NNS	denotes	cells
T824	1276-1280	VBP	denotes	play
T825	1281-1282	DT	denotes	a
T827	1283-1290	JJ	denotes	primary
T826	1291-1295	NN	denotes	role
T828	1296-1298	IN	denotes	in
T829	1299-1305	NN	denotes	vision
T830	1306-1308	IN	denotes	by
T831	1309-1318	VBG	denotes	capturing
T832	1319-1324	NN	denotes	light
T833	1325-1331	NN	denotes	energy
T834	1332-1335	CC	denotes	and
T835	1336-1346	VBG	denotes	converting
T836	1347-1349	PRP	denotes	it
T837	1350-1354	IN	denotes	into
T838	1355-1361	JJ	denotes	neural
T839	1362-1369	NNS	denotes	stimuli
T840	1369-1370	.	denotes	.
T841	1370-1456	sentence	denotes	These sensory neurons are a shared element in all organisms capable of sensing light.
T842	1371-1376	DT	denotes	These
T844	1377-1384	JJ	denotes	sensory
T843	1385-1392	NNS	denotes	neurons
T845	1393-1396	VBP	denotes	are
T846	1397-1398	DT	denotes	a
T848	1399-1405	VBN	denotes	shared
T847	1406-1413	NN	denotes	element
T849	1414-1416	IN	denotes	in
T850	1417-1420	DT	denotes	all
T851	1421-1430	NNS	denotes	organisms
T852	1431-1438	JJ	denotes	capable
T853	1439-1441	IN	denotes	of
T854	1442-1449	VBG	denotes	sensing
T855	1450-1455	NN	denotes	light
T856	1455-1456	.	denotes	.
T857	1456-1596	sentence	denotes	In humans, genetic diseases of the eye are common and the primary site of disease is most frequently photoreceptors (for review see [1-3]).
T858	1457-1459	IN	denotes	In
T860	1460-1466	NNS	denotes	humans
T861	1466-1468	,	denotes	,
T862	1468-1475	JJ	denotes	genetic
T863	1476-1484	NNS	denotes	diseases
T864	1485-1487	IN	denotes	of
T865	1488-1491	DT	denotes	the
T866	1492-1495	NN	denotes	eye
T859	1496-1499	VBP	denotes	are
T867	1500-1506	JJ	denotes	common
T868	1507-1510	CC	denotes	and
T869	1511-1514	DT	denotes	the
T871	1515-1522	JJ	denotes	primary
T870	1523-1527	NN	denotes	site
T873	1528-1530	IN	denotes	of
T874	1531-1538	NN	denotes	disease
T872	1539-1541	VBZ	denotes	is
T875	1542-1546	RBS	denotes	most
T876	1547-1557	RB	denotes	frequently
T877	1558-1572	NNS	denotes	photoreceptors
T878	1573-1574	-LRB-	denotes	(
T880	1574-1577	IN	denotes	for
T881	1578-1584	NN	denotes	review
T879	1585-1588	VBP	denotes	see
T882	1589-1590	-LRB-	denotes	[
T883	1590-1591	CD	denotes	1
T884	1591-1592	SYM	denotes	-
T885	1592-1593	CD	denotes	3
T886	1593-1594	-RRB-	denotes	]
T887	1594-1595	-RRB-	denotes	)
T888	1595-1596	.	denotes	.
T889	1596-1718	sentence	denotes	Photoreceptors have been well studied, particularly with respect to the biochemistry and physiology of phototransduction.
T890	1597-1611	NNS	denotes	Photoreceptors
T892	1612-1616	VBP	denotes	have
T893	1617-1621	VBN	denotes	been
T894	1622-1626	RB	denotes	well
T891	1627-1634	VBN	denotes	studied
T895	1634-1636	,	denotes	,
T896	1636-1648	RB	denotes	particularly
T897	1649-1653	IN	denotes	with
T898	1654-1661	NN	denotes	respect
T899	1662-1664	IN	denotes	to
T900	1665-1668	DT	denotes	the
T901	1669-1681	NN	denotes	biochemistry
T902	1682-1685	CC	denotes	and
T903	1686-1696	NN	denotes	physiology
T904	1697-1699	IN	denotes	of
T905	1700-1717	NN	denotes	phototransduction
T906	1717-1718	.	denotes	.
T907	1718-1835	sentence	denotes	Insight into the development of vertebrate photoreceptors, however, has lagged behind our understanding of function.
T908	1719-1726	NN	denotes	Insight
T910	1727-1731	IN	denotes	into
T911	1732-1735	DT	denotes	the
T912	1736-1747	NN	denotes	development
T913	1748-1750	IN	denotes	of
T914	1751-1761	NN	denotes	vertebrate
T915	1762-1776	NNS	denotes	photoreceptors
T916	1776-1778	,	denotes	,
T917	1778-1785	RB	denotes	however
T918	1785-1787	,	denotes	,
T919	1787-1790	VBZ	denotes	has
T909	1791-1797	VBN	denotes	lagged
T920	1798-1804	IN	denotes	behind
T921	1805-1808	PRP$	denotes	our
T922	1809-1822	NN	denotes	understanding
T923	1823-1825	IN	denotes	of
T924	1826-1834	NN	denotes	function
T925	1834-1835	.	denotes	.
T926	1835-1963	sentence	denotes	Only recently have the first molecular mechanisms regulating photoreceptor development been identified (for review see, [2,4]).
T927	1836-1840	RB	denotes	Only
T928	1841-1849	RB	denotes	recently
T930	1850-1854	VB	denotes	have
T931	1855-1858	DT	denotes	the
T933	1859-1864	JJ	denotes	first
T934	1865-1874	JJ	denotes	molecular
T932	1875-1885	NNS	denotes	mechanisms
T935	1886-1896	VBG	denotes	regulating
T936	1897-1910	NN	denotes	photoreceptor
T937	1911-1922	NN	denotes	development
T938	1923-1927	VBN	denotes	been
T929	1928-1938	VBN	denotes	identified
T939	1939-1940	-LRB-	denotes	(
T941	1940-1943	IN	denotes	for
T942	1944-1950	NN	denotes	review
T940	1951-1954	VB	denotes	see
T943	1954-1956	,	denotes	,
T944	1956-1957	-LRB-	denotes	[
T945	1957-1958	CD	denotes	2
T947	1958-1959	,	denotes	,
T946	1959-1960	CD	denotes	4
T948	1960-1961	-RRB-	denotes	]
T949	1961-1962	-RRB-	denotes	)
T950	1962-1963	.	denotes	.
T951	1963-2126	sentence	denotes	Crx (cone-rod homeobox) is an otx-family homeobox gene expressed predominantly in photoreceptors, from early in their development through to the adult ages [5-7].
T952	1964-1967	NN	denotes	Crx
T954	1968-1969	-LRB-	denotes	(
T955	1969-1973	NN	denotes	cone
T957	1973-1974	HYPH	denotes	-
T956	1974-1977	NN	denotes	rod
T958	1978-1986	NN	denotes	homeobox
T959	1986-1987	-RRB-	denotes	)
T953	1988-1990	VBZ	denotes	is
T960	1991-1993	DT	denotes	an
T962	1994-1997	NN	denotes	otx
T964	1997-1998	HYPH	denotes	-
T963	1998-2004	NN	denotes	family
T965	2005-2013	NN	denotes	homeobox
T961	2014-2018	NN	denotes	gene
T966	2019-2028	VBN	denotes	expressed
T967	2029-2042	RB	denotes	predominantly
T968	2043-2045	IN	denotes	in
T969	2046-2060	NNS	denotes	photoreceptors
T970	2060-2062	,	denotes	,
T971	2062-2066	IN	denotes	from
T972	2067-2072	RB	denotes	early
T973	2073-2075	IN	denotes	in
T974	2076-2081	PRP$	denotes	their
T975	2082-2093	NN	denotes	development
T976	2094-2101	IN	denotes	through
T977	2102-2104	IN	denotes	to
T978	2105-2108	DT	denotes	the
T980	2109-2114	JJ	denotes	adult
T979	2115-2119	NNS	denotes	ages
T981	2120-2121	-LRB-	denotes	[
T982	2121-2122	CD	denotes	5
T983	2122-2123	SYM	denotes	-
T984	2123-2124	CD	denotes	7
T985	2124-2125	-RRB-	denotes	]
T986	2125-2126	.	denotes	.
T987	2126-2277	sentence	denotes	Crx gene expression is critically dependent upon Otx2, another member of the same homeobox family which is expressed in early photoreceptor cells [8].
T988	2127-2130	NN	denotes	Crx
T990	2131-2135	NN	denotes	gene
T989	2136-2146	NN	denotes	expression
T991	2147-2149	VBZ	denotes	is
T992	2150-2160	RB	denotes	critically
T993	2161-2170	JJ	denotes	dependent
T994	2171-2175	IN	denotes	upon
T995	2176-2180	NN	denotes	Otx2
T996	2180-2182	,	denotes	,
T997	2182-2189	DT	denotes	another
T998	2190-2196	NN	denotes	member
T999	2197-2199	IN	denotes	of
T1000	2200-2203	DT	denotes	the
T1002	2204-2208	JJ	denotes	same
T1003	2209-2217	NN	denotes	homeobox
T1001	2218-2224	NN	denotes	family
T1004	2225-2230	WDT	denotes	which
T1006	2231-2233	VBZ	denotes	is
T1005	2234-2243	VBN	denotes	expressed
T1007	2244-2246	IN	denotes	in
T1008	2247-2252	JJ	denotes	early
T1010	2253-2266	NN	denotes	photoreceptor
T1009	2267-2272	NNS	denotes	cells
T1011	2273-2274	-LRB-	denotes	[
T1012	2274-2275	CD	denotes	8
T1013	2275-2276	-RRB-	denotes	]
T1014	2276-2277	.	denotes	.
T1015	2277-2449	sentence	denotes	In rod photoreceptors, Crx appears to work in concert with Nrl, a leucine zipper protein that is also restricted in its expression in the retina to rod photoreceptors [9].
T1016	2278-2280	IN	denotes	In
T1018	2281-2284	NN	denotes	rod
T1019	2285-2299	NNS	denotes	photoreceptors
T1020	2299-2301	,	denotes	,
T1021	2301-2304	NN	denotes	Crx
T1017	2305-2312	VBZ	denotes	appears
T1022	2313-2315	TO	denotes	to
T1023	2316-2320	VB	denotes	work
T1024	2321-2323	IN	denotes	in
T1025	2324-2331	NN	denotes	concert
T1026	2332-2336	IN	denotes	with
T1027	2337-2340	NN	denotes	Nrl
T1028	2340-2342	,	denotes	,
T1029	2342-2343	DT	denotes	a
T1031	2344-2351	NN	denotes	leucine
T1032	2352-2358	NN	denotes	zipper
T1030	2359-2366	NN	denotes	protein
T1033	2367-2371	WDT	denotes	that
T1035	2372-2374	VBZ	denotes	is
T1036	2375-2379	RB	denotes	also
T1034	2380-2390	VBN	denotes	restricted
T1037	2391-2393	IN	denotes	in
T1038	2394-2397	PRP$	denotes	its
T1039	2398-2408	NN	denotes	expression
T1040	2409-2411	IN	denotes	in
T1041	2412-2415	DT	denotes	the
T1042	2416-2422	NN	denotes	retina
T1043	2423-2425	IN	denotes	to
T1044	2426-2429	NN	denotes	rod
T1045	2430-2444	NNS	denotes	photoreceptors
T1046	2445-2446	-LRB-	denotes	[
T1047	2446-2447	CD	denotes	9
T1048	2447-2448	-RRB-	denotes	]
T1049	2448-2449	.	denotes	.
T1050	2449-2596	sentence	denotes	Many photoreceptor-specific genes have putative Crx-binding elements in their regulatory regions [10], including rhodopsin [11] and arrestin [12].
T1051	2450-2454	JJ	denotes	Many
T1053	2455-2468	NN	denotes	photoreceptor
T1055	2468-2469	HYPH	denotes	-
T1054	2469-2477	JJ	denotes	specific
T1052	2478-2483	NNS	denotes	genes
T1056	2484-2488	VBP	denotes	have
T1057	2489-2497	JJ	denotes	putative
T1059	2498-2501	NN	denotes	Crx
T1061	2501-2502	HYPH	denotes	-
T1060	2502-2509	VBG	denotes	binding
T1058	2510-2518	NNS	denotes	elements
T1062	2519-2521	IN	denotes	in
T1063	2522-2527	PRP$	denotes	their
T1065	2528-2538	JJ	denotes	regulatory
T1064	2539-2546	NNS	denotes	regions
T1066	2547-2548	-LRB-	denotes	[
T1067	2548-2550	CD	denotes	10
T1068	2550-2551	-RRB-	denotes	]
T1069	2551-2553	,	denotes	,
T1070	2553-2562	VBG	denotes	including
T1071	2563-2572	NN	denotes	rhodopsin
T1072	2573-2574	-LRB-	denotes	[
T1073	2574-2576	CD	denotes	11
T1074	2576-2577	-RRB-	denotes	]
T1075	2578-2581	CC	denotes	and
T1076	2582-2590	NN	denotes	arrestin
T1077	2591-2592	-LRB-	denotes	[
T1078	2592-2594	CD	denotes	12
T1079	2594-2595	-RRB-	denotes	]
T1080	2595-2596	.	denotes	.
T1081	2596-2772	sentence	denotes	Mutations in Crx have been associated with several human diseases that lead to blindness, including cone-rod dystrophy 2 [6,13,14], retinitis pigmentosa [14], and LCA [14-16].
T1082	2597-2606	NNS	denotes	Mutations
T1084	2607-2609	IN	denotes	in
T1085	2610-2613	NN	denotes	Crx
T1086	2614-2618	VBP	denotes	have
T1087	2619-2623	VBN	denotes	been
T1083	2624-2634	VBN	denotes	associated
T1088	2635-2639	IN	denotes	with
T1089	2640-2647	JJ	denotes	several
T1091	2648-2653	JJ	denotes	human
T1090	2654-2662	NNS	denotes	diseases
T1092	2663-2667	WDT	denotes	that
T1093	2668-2672	VBP	denotes	lead
T1094	2673-2675	IN	denotes	to
T1095	2676-2685	NN	denotes	blindness
T1096	2685-2687	,	denotes	,
T1097	2687-2696	VBG	denotes	including
T1098	2697-2701	NN	denotes	cone
T1100	2701-2702	HYPH	denotes	-
T1099	2702-2705	NN	denotes	rod
T1101	2706-2715	NN	denotes	dystrophy
T1102	2716-2717	CD	denotes	2
T1103	2718-2719	-LRB-	denotes	[
T1105	2719-2720	CD	denotes	6
T1106	2720-2721	,	denotes	,
T1107	2721-2723	CD	denotes	13
T1108	2723-2724	,	denotes	,
T1104	2724-2726	CD	denotes	14
T1109	2726-2727	-RRB-	denotes	]
T1110	2727-2729	,	denotes	,
T1111	2729-2738	NN	denotes	retinitis
T1112	2739-2749	NN	denotes	pigmentosa
T1113	2750-2751	-LRB-	denotes	[
T1114	2751-2753	CD	denotes	14
T1115	2753-2754	-RRB-	denotes	]
T1116	2754-2756	,	denotes	,
T1117	2756-2759	CC	denotes	and
T1118	2760-2763	NN	denotes	LCA
T1119	2764-2765	-LRB-	denotes	[
T1120	2765-2767	CD	denotes	14
T1121	2767-2768	SYM	denotes	-
T1122	2768-2770	CD	denotes	16
T1123	2770-2771	-RRB-	denotes	]
T1124	2771-2772	.	denotes	.
T1125	2772-2908	sentence	denotes	Based on these data, Crx was hypothesized to play a critical role in the differentiation and maintainance of photoreceptor cells [5,7].
T1126	2773-2778	VBN	denotes	Based
T1128	2779-2781	IN	denotes	on
T1129	2782-2787	DT	denotes	these
T1130	2788-2792	NNS	denotes	data
T1131	2792-2794	,	denotes	,
T1132	2794-2797	NN	denotes	Crx
T1133	2798-2801	VBD	denotes	was
T1127	2802-2814	VBN	denotes	hypothesized
T1134	2815-2817	TO	denotes	to
T1135	2818-2822	VB	denotes	play
T1136	2823-2824	DT	denotes	a
T1138	2825-2833	JJ	denotes	critical
T1137	2834-2838	NN	denotes	role
T1139	2839-2841	IN	denotes	in
T1140	2842-2845	DT	denotes	the
T1141	2846-2861	NN	denotes	differentiation
T1142	2862-2865	CC	denotes	and
T1143	2866-2878	NN	denotes	maintainance
T1144	2879-2881	IN	denotes	of
T1145	2882-2895	NN	denotes	photoreceptor
T1146	2896-2901	NNS	denotes	cells
T1147	2902-2903	-LRB-	denotes	[
T1149	2903-2904	CD	denotes	5
T1150	2904-2905	,	denotes	,
T1148	2905-2906	CD	denotes	7
T1151	2906-2907	-RRB-	denotes	]
T1152	2907-2908	.	denotes	.
T1153	2908-2996	sentence	denotes	LCA is the most severe genetic disease of photoreceptors (see [17], for recent review).
T1154	2909-2912	NN	denotes	LCA
T1155	2913-2915	VBZ	denotes	is
T1156	2916-2919	DT	denotes	the
T1158	2920-2924	RBS	denotes	most
T1159	2925-2931	JJ	denotes	severe
T1160	2932-2939	JJ	denotes	genetic
T1157	2940-2947	NN	denotes	disease
T1161	2948-2950	IN	denotes	of
T1162	2951-2965	NNS	denotes	photoreceptors
T1163	2966-2967	-LRB-	denotes	(
T1164	2967-2970	VB	denotes	see
T1165	2971-2972	-LRB-	denotes	[
T1166	2972-2974	CD	denotes	17
T1167	2974-2975	-RRB-	denotes	]
T1168	2975-2977	,	denotes	,
T1169	2977-2980	IN	denotes	for
T1170	2981-2987	JJ	denotes	recent
T1171	2988-2994	NN	denotes	review
T1172	2994-2995	-RRB-	denotes	)
T1173	2995-2996	.	denotes	.
T1174	2996-3079	sentence	denotes	Affected infants exhibit a complete or near complete absence of vision from birth.
T1175	2997-3005	VBN	denotes	Affected
T1176	3006-3013	NNS	denotes	infants
T1177	3014-3021	VBP	denotes	exhibit
T1178	3022-3023	DT	denotes	a
T1180	3024-3032	JJ	denotes	complete
T1181	3033-3035	CC	denotes	or
T1182	3036-3040	RB	denotes	near
T1183	3041-3049	JJ	denotes	complete
T1179	3050-3057	NN	denotes	absence
T1184	3058-3060	IN	denotes	of
T1185	3061-3067	NN	denotes	vision
T1186	3068-3072	IN	denotes	from
T1187	3073-3078	NN	denotes	birth
T1188	3078-3079	.	denotes	.
T1189	3079-3248	sentence	denotes	Mutations in retinal specific genes, such as Crx, have been associated with LCA [14,15], as well as GUCY2D [18], RPE65 [19], AIPL-1 [20], CRB-1 [21], and RPGRIP-1 [22].
T1190	3080-3089	NNS	denotes	Mutations
T1192	3090-3092	IN	denotes	in
T1193	3093-3100	NN	denotes	retinal
T1194	3101-3109	JJ	denotes	specific
T1195	3110-3115	NNS	denotes	genes
T1196	3115-3117	,	denotes	,
T1197	3117-3121	JJ	denotes	such
T1198	3122-3124	IN	denotes	as
T1199	3125-3128	NN	denotes	Crx
T1200	3128-3130	,	denotes	,
T1201	3130-3134	VBP	denotes	have
T1202	3135-3139	VBN	denotes	been
T1191	3140-3150	VBN	denotes	associated
T1203	3151-3155	IN	denotes	with
T1204	3156-3159	NN	denotes	LCA
T1205	3160-3161	-LRB-	denotes	[
T1207	3161-3163	CD	denotes	14
T1208	3163-3164	,	denotes	,
T1206	3164-3166	CD	denotes	15
T1209	3166-3167	-RRB-	denotes	]
T1210	3167-3169	,	denotes	,
T1211	3169-3171	RB	denotes	as
T1213	3172-3176	RB	denotes	well
T1212	3177-3179	IN	denotes	as
T1214	3180-3186	NN	denotes	GUCY2D
T1215	3187-3188	-LRB-	denotes	[
T1216	3188-3190	CD	denotes	18
T1217	3190-3191	-RRB-	denotes	]
T1218	3191-3193	,	denotes	,
T1219	3193-3198	NN	denotes	RPE65
T1220	3199-3200	-LRB-	denotes	[
T1221	3200-3202	CD	denotes	19
T1222	3202-3203	-RRB-	denotes	]
T1223	3203-3205	,	denotes	,
T1224	3205-3209	NN	denotes	AIPL
T1225	3209-3210	HYPH	denotes	-
T1226	3210-3211	CD	denotes	1
T1227	3212-3213	-LRB-	denotes	[
T1228	3213-3215	CD	denotes	20
T1229	3215-3216	-RRB-	denotes	]
T1230	3216-3218	,	denotes	,
T1231	3218-3221	NN	denotes	CRB
T1232	3221-3222	HYPH	denotes	-
T1233	3222-3223	CD	denotes	1
T1234	3224-3225	-LRB-	denotes	[
T1235	3225-3227	CD	denotes	21
T1236	3227-3228	-RRB-	denotes	]
T1237	3228-3230	,	denotes	,
T1238	3230-3233	CC	denotes	and
T1239	3234-3240	NN	denotes	RPGRIP
T1240	3240-3241	HYPH	denotes	-
T1241	3241-3242	CD	denotes	1
T1242	3243-3244	-LRB-	denotes	[
T1243	3244-3246	CD	denotes	22
T1244	3246-3247	-RRB-	denotes	]
T1245	3247-3248	.	denotes	.
T1246	3248-3361	sentence	denotes	There also may be as many as three additional genetically linked loci where genes have not been identified [23].
T1247	3249-3254	EX	denotes	There
T1249	3255-3259	RB	denotes	also
T1250	3260-3263	MD	denotes	may
T1248	3264-3266	VB	denotes	be
T1251	3267-3269	RB	denotes	as
T1253	3270-3274	JJ	denotes	many
T1254	3275-3277	IN	denotes	as
T1252	3278-3283	CD	denotes	three
T1256	3284-3294	JJ	denotes	additional
T1257	3295-3306	RB	denotes	genetically
T1258	3307-3313	VBN	denotes	linked
T1255	3314-3318	NNS	denotes	loci
T1259	3319-3324	WRB	denotes	where
T1261	3325-3330	NNS	denotes	genes
T1262	3331-3335	VBP	denotes	have
T1263	3336-3339	RB	denotes	not
T1264	3340-3344	VBN	denotes	been
T1260	3345-3355	VBN	denotes	identified
T1265	3356-3357	-LRB-	denotes	[
T1266	3357-3359	CD	denotes	23
T1267	3359-3360	-RRB-	denotes	]
T1268	3360-3361	.	denotes	.
T1269	3361-3503	sentence	denotes	Crx mutations in LCA are varied, and include a putative dominant mutation that is proposed to encode a dominant-negative form of Crx [14,15].
T1270	3362-3365	NN	denotes	Crx
T1271	3366-3375	NNS	denotes	mutations
T1273	3376-3378	IN	denotes	in
T1274	3379-3382	NN	denotes	LCA
T1272	3383-3386	VBP	denotes	are
T1275	3387-3393	JJ	denotes	varied
T1276	3393-3395	,	denotes	,
T1277	3395-3398	CC	denotes	and
T1278	3399-3406	VBP	denotes	include
T1279	3407-3408	DT	denotes	a
T1281	3409-3417	JJ	denotes	putative
T1282	3418-3426	JJ	denotes	dominant
T1280	3427-3435	NN	denotes	mutation
T1283	3436-3440	WDT	denotes	that
T1285	3441-3443	VBZ	denotes	is
T1284	3444-3452	VBN	denotes	proposed
T1286	3453-3455	TO	denotes	to
T1287	3456-3462	VB	denotes	encode
T1288	3463-3464	DT	denotes	a
T1290	3465-3473	JJ	denotes	dominant
T1292	3473-3474	HYPH	denotes	-
T1291	3474-3482	JJ	denotes	negative
T1289	3483-3487	NN	denotes	form
T1293	3488-3490	IN	denotes	of
T1294	3491-3494	NN	denotes	Crx
T1295	3495-3496	-LRB-	denotes	[
T1297	3496-3498	CD	denotes	14
T1298	3498-3499	,	denotes	,
T1296	3499-3501	CD	denotes	15
T1299	3501-3502	-RRB-	denotes	]
T1300	3502-3503	.	denotes	.
T1301	3503-3631	sentence	denotes	Recessive mutations also have been reported and at least one allele encodes a protein with decreased DNA-binding activity [16].
T1302	3504-3513	JJ	denotes	Recessive
T1303	3514-3523	NNS	denotes	mutations
T1305	3524-3528	RB	denotes	also
T1306	3529-3533	VBP	denotes	have
T1307	3534-3538	VBN	denotes	been
T1304	3539-3547	VBN	denotes	reported
T1308	3548-3551	CC	denotes	and
T1309	3552-3554	RB	denotes	at
T1311	3555-3560	RBS	denotes	least
T1310	3561-3564	CD	denotes	one
T1312	3565-3571	NN	denotes	allele
T1313	3572-3579	VBZ	denotes	encodes
T1314	3580-3581	DT	denotes	a
T1315	3582-3589	NN	denotes	protein
T1316	3590-3594	IN	denotes	with
T1317	3595-3604	VBN	denotes	decreased
T1319	3605-3608	NN	denotes	DNA
T1320	3608-3609	HYPH	denotes	-
T1321	3609-3616	VBG	denotes	binding
T1318	3617-3625	NN	denotes	activity
T1322	3626-3627	-LRB-	denotes	[
T1323	3627-3629	CD	denotes	16
T1324	3629-3630	-RRB-	denotes	]
T1325	3630-3631	.	denotes	.
T1326	3631-3783	sentence	denotes	Histopathological and ultrastructural studies of LCA should enable a better understanding of the disease process, and the design of suitable therapies.
T1327	3632-3649	JJ	denotes	Histopathological
T1329	3650-3653	CC	denotes	and
T1330	3654-3669	JJ	denotes	ultrastructural
T1328	3670-3677	NNS	denotes	studies
T1332	3678-3680	IN	denotes	of
T1333	3681-3684	NN	denotes	LCA
T1334	3685-3691	MD	denotes	should
T1331	3692-3698	VB	denotes	enable
T1335	3699-3700	DT	denotes	a
T1337	3701-3707	JJR	denotes	better
T1336	3708-3721	NN	denotes	understanding
T1338	3722-3724	IN	denotes	of
T1339	3725-3728	DT	denotes	the
T1341	3729-3736	NN	denotes	disease
T1340	3737-3744	NN	denotes	process
T1342	3744-3746	,	denotes	,
T1343	3746-3749	CC	denotes	and
T1344	3750-3753	DT	denotes	the
T1345	3754-3760	NN	denotes	design
T1346	3761-3763	IN	denotes	of
T1347	3764-3772	JJ	denotes	suitable
T1348	3773-3782	NNS	denotes	therapies
T1349	3782-3783	.	denotes	.
T1350	3783-3961	sentence	denotes	Few such studies exist for human LCA (reviewed in [17]) and the majority of such studies examine the globes of adults with LCA, after the tissue has undergone secondary changes.
T1351	3784-3787	JJ	denotes	Few
T1353	3788-3792	JJ	denotes	such
T1352	3793-3800	NNS	denotes	studies
T1354	3801-3806	VBP	denotes	exist
T1355	3807-3810	IN	denotes	for
T1356	3811-3816	JJ	denotes	human
T1357	3817-3820	NN	denotes	LCA
T1358	3821-3822	-LRB-	denotes	(
T1359	3822-3830	VBN	denotes	reviewed
T1360	3831-3833	IN	denotes	in
T1361	3834-3835	-LRB-	denotes	[
T1362	3835-3837	CD	denotes	17
T1363	3837-3838	-RRB-	denotes	]
T1364	3838-3839	-RRB-	denotes	)
T1365	3840-3843	CC	denotes	and
T1366	3844-3847	DT	denotes	the
T1367	3848-3856	NN	denotes	majority
T1369	3857-3859	IN	denotes	of
T1370	3860-3864	JJ	denotes	such
T1371	3865-3872	NNS	denotes	studies
T1368	3873-3880	VBP	denotes	examine
T1372	3881-3884	DT	denotes	the
T1373	3885-3891	NNS	denotes	globes
T1374	3892-3894	IN	denotes	of
T1375	3895-3901	NNS	denotes	adults
T1376	3902-3906	IN	denotes	with
T1377	3907-3910	NN	denotes	LCA
T1378	3910-3912	,	denotes	,
T1379	3912-3917	IN	denotes	after
T1381	3918-3921	DT	denotes	the
T1382	3922-3928	NN	denotes	tissue
T1383	3929-3932	VBZ	denotes	has
T1380	3933-3942	VBN	denotes	undergone
T1384	3943-3952	JJ	denotes	secondary
T1385	3953-3960	NNS	denotes	changes
T1386	3960-3961	.	denotes	.
T1387	3961-4045	sentence	denotes	Only a single study exists where the developing eye of an infant was examined [24].
T1388	3962-3966	RB	denotes	Only
T1390	3967-3968	DT	denotes	a
T1391	3969-3975	JJ	denotes	single
T1389	3976-3981	NN	denotes	study
T1392	3982-3988	VBZ	denotes	exists
T1393	3989-3994	WRB	denotes	where
T1395	3995-3998	DT	denotes	the
T1397	3999-4009	VBG	denotes	developing
T1396	4010-4013	NN	denotes	eye
T1398	4014-4016	IN	denotes	of
T1399	4017-4019	DT	denotes	an
T1400	4020-4026	NN	denotes	infant
T1401	4027-4030	VBD	denotes	was
T1394	4031-4039	VBN	denotes	examined
T1402	4040-4041	-LRB-	denotes	[
T1403	4041-4043	CD	denotes	24
T1404	4043-4044	-RRB-	denotes	]
T1405	4044-4045	.	denotes	.
T1406	4045-4190	sentence	denotes	Animal models for LCA have recently been reported and have already served to broaden our understanding of the pathology of this disease [25-28].
T1407	4046-4052	NN	denotes	Animal
T1408	4053-4059	NNS	denotes	models
T1410	4060-4063	IN	denotes	for
T1411	4064-4067	NN	denotes	LCA
T1412	4068-4072	VBP	denotes	have
T1413	4073-4081	RB	denotes	recently
T1414	4082-4086	VBN	denotes	been
T1409	4087-4095	VBN	denotes	reported
T1415	4096-4099	CC	denotes	and
T1416	4100-4104	VBP	denotes	have
T1418	4105-4112	RB	denotes	already
T1417	4113-4119	VBN	denotes	served
T1419	4120-4122	TO	denotes	to
T1420	4123-4130	VB	denotes	broaden
T1421	4131-4134	PRP$	denotes	our
T1422	4135-4148	NN	denotes	understanding
T1423	4149-4151	IN	denotes	of
T1424	4152-4155	DT	denotes	the
T1425	4156-4165	NN	denotes	pathology
T1426	4166-4168	IN	denotes	of
T1427	4169-4173	DT	denotes	this
T1428	4174-4181	NN	denotes	disease
T1429	4182-4183	-LRB-	denotes	[
T1430	4183-4185	CD	denotes	25
T1431	4185-4186	SYM	denotes	-
T1432	4186-4188	CD	denotes	28
T1433	4188-4189	-RRB-	denotes	]
T1434	4189-4190	.	denotes	.
T1435	4190-4388	sentence	denotes	Since LCA is a clinically and genetically heterogeneous disorder, additional mouse models are in order to allow a full understanding of the many ways in which photoreceptor development can go awry.
T1436	4191-4196	IN	denotes	Since
T1438	4197-4200	NN	denotes	LCA
T1437	4201-4203	VBZ	denotes	is
T1440	4204-4205	DT	denotes	a
T1442	4206-4216	RB	denotes	clinically
T1444	4217-4220	CC	denotes	and
T1445	4221-4232	RB	denotes	genetically
T1443	4233-4246	JJ	denotes	heterogeneous
T1441	4247-4255	NN	denotes	disorder
T1446	4255-4257	,	denotes	,
T1447	4257-4267	JJ	denotes	additional
T1449	4268-4273	NN	denotes	mouse
T1448	4274-4280	NNS	denotes	models
T1439	4281-4284	VBP	denotes	are
T1450	4285-4287	IN	denotes	in
T1451	4288-4293	NN	denotes	order
T1452	4294-4296	TO	denotes	to
T1453	4297-4302	VB	denotes	allow
T1454	4303-4304	DT	denotes	a
T1456	4305-4309	JJ	denotes	full
T1455	4310-4323	NN	denotes	understanding
T1457	4324-4326	IN	denotes	of
T1458	4327-4330	DT	denotes	the
T1460	4331-4335	JJ	denotes	many
T1459	4336-4340	NNS	denotes	ways
T1461	4341-4343	IN	denotes	in
T1463	4344-4349	WDT	denotes	which
T1464	4350-4363	NN	denotes	photoreceptor
T1465	4364-4375	NN	denotes	development
T1466	4376-4379	MD	denotes	can
T1462	4380-4382	VB	denotes	go
T1467	4383-4387	JJ	denotes	awry
T1468	4387-4388	.	denotes	.
T1469	4388-4532	sentence	denotes	In addition to their importance as a locus of disease, photoreceptor cells serve as an excellent model for studies in neuronal differentiation.
T1470	4389-4391	IN	denotes	In
T1472	4392-4400	NN	denotes	addition
T1473	4401-4403	IN	denotes	to
T1474	4404-4409	PRP$	denotes	their
T1475	4410-4420	NN	denotes	importance
T1476	4421-4423	IN	denotes	as
T1477	4424-4425	DT	denotes	a
T1478	4426-4431	NN	denotes	locus
T1479	4432-4434	IN	denotes	of
T1480	4435-4442	NN	denotes	disease
T1481	4442-4444	,	denotes	,
T1482	4444-4457	NN	denotes	photoreceptor
T1483	4458-4463	NNS	denotes	cells
T1471	4464-4469	VBP	denotes	serve
T1484	4470-4472	IN	denotes	as
T1485	4473-4475	DT	denotes	an
T1487	4476-4485	JJ	denotes	excellent
T1486	4486-4491	NN	denotes	model
T1488	4492-4495	IN	denotes	for
T1489	4496-4503	NNS	denotes	studies
T1490	4504-4506	IN	denotes	in
T1491	4507-4515	JJ	denotes	neuronal
T1492	4516-4531	NN	denotes	differentiation
T1493	4531-4532	.	denotes	.
T1494	4532-4574	sentence	denotes	Photoreceptor cells are highly polarized.
T1495	4533-4546	NN	denotes	Photoreceptor
T1496	4547-4552	NNS	denotes	cells
T1497	4553-4556	VBP	denotes	are
T1498	4557-4563	RB	denotes	highly
T1499	4564-4573	JJ	denotes	polarized
T1500	4573-4574	.	denotes	.
T1501	4574-4703	sentence	denotes	At their apex, these neurons have a membranous outer segment, which contains proteins involved in the phototransduction cascade.
T1502	4575-4577	IN	denotes	At
T1504	4578-4583	PRP$	denotes	their
T1505	4584-4588	NN	denotes	apex
T1506	4588-4590	,	denotes	,
T1507	4590-4595	DT	denotes	these
T1508	4596-4603	NNS	denotes	neurons
T1503	4604-4608	VBP	denotes	have
T1509	4609-4610	DT	denotes	a
T1511	4611-4621	JJ	denotes	membranous
T1512	4622-4627	JJ	denotes	outer
T1510	4628-4635	NN	denotes	segment
T1513	4635-4637	,	denotes	,
T1514	4637-4642	WDT	denotes	which
T1515	4643-4651	VBZ	denotes	contains
T1516	4652-4660	NN	denotes	proteins
T1517	4661-4669	VBN	denotes	involved
T1518	4670-4672	IN	denotes	in
T1519	4673-4676	DT	denotes	the
T1521	4677-4694	NN	denotes	phototransduction
T1520	4695-4702	NN	denotes	cascade
T1522	4702-4703	.	denotes	.
T1523	4703-4840	sentence	denotes	Loss of function mutations in rhodopsin [29], or the structural protein, peripherin [30], result in an inability to form outer segments.
T1524	4704-4708	NN	denotes	Loss
T1526	4709-4711	IN	denotes	of
T1527	4712-4720	NN	denotes	function
T1525	4721-4730	NNS	denotes	mutations
T1529	4731-4733	IN	denotes	in
T1530	4734-4743	NN	denotes	rhodopsin
T1531	4744-4745	-LRB-	denotes	[
T1532	4745-4747	CD	denotes	29
T1533	4747-4748	-RRB-	denotes	]
T1534	4748-4750	,	denotes	,
T1535	4750-4752	CC	denotes	or
T1536	4753-4756	DT	denotes	the
T1538	4757-4767	JJ	denotes	structural
T1537	4768-4775	NN	denotes	protein
T1539	4775-4777	,	denotes	,
T1540	4777-4787	NN	denotes	peripherin
T1541	4788-4789	-LRB-	denotes	[
T1542	4789-4791	CD	denotes	30
T1543	4791-4792	-RRB-	denotes	]
T1544	4792-4794	,	denotes	,
T1528	4794-4800	VBP	denotes	result
T1545	4801-4803	IN	denotes	in
T1546	4804-4806	DT	denotes	an
T1547	4807-4816	NN	denotes	inability
T1548	4817-4819	TO	denotes	to
T1549	4820-4824	VB	denotes	form
T1550	4825-4830	JJ	denotes	outer
T1551	4831-4839	NNS	denotes	segments
T1552	4839-4840	.	denotes	.
T1553	4840-4989	sentence	denotes	At the other extremity, photoreceptors terminate with synaptic endings that make contact with the processes of horizontal and bipolar cells [31,32].
T1554	4841-4843	IN	denotes	At
T1556	4844-4847	DT	denotes	the
T1558	4848-4853	JJ	denotes	other
T1557	4854-4863	NN	denotes	extremity
T1559	4863-4865	,	denotes	,
T1560	4865-4879	NNS	denotes	photoreceptors
T1555	4880-4889	VBP	denotes	terminate
T1561	4890-4894	IN	denotes	with
T1562	4895-4903	JJ	denotes	synaptic
T1563	4904-4911	NNS	denotes	endings
T1564	4912-4916	WDT	denotes	that
T1565	4917-4921	VBP	denotes	make
T1566	4922-4929	NN	denotes	contact
T1567	4930-4934	IN	denotes	with
T1568	4935-4938	DT	denotes	the
T1569	4939-4948	NNS	denotes	processes
T1570	4949-4951	IN	denotes	of
T1571	4952-4962	JJ	denotes	horizontal
T1573	4963-4966	CC	denotes	and
T1574	4967-4974	JJ	denotes	bipolar
T1572	4975-4980	NNS	denotes	cells
T1575	4981-4982	-LRB-	denotes	[
T1577	4982-4984	CD	denotes	31
T1578	4984-4985	,	denotes	,
T1576	4985-4987	CD	denotes	32
T1579	4987-4988	-RRB-	denotes	]
T1580	4988-4989	.	denotes	.
T1581	4989-5104	sentence	denotes	Rod spherules establish an invaginating synapse with rod bipolar dendrites and axonal endings of horizontal cells.
T1582	4990-4993	NN	denotes	Rod
T1583	4994-5003	NNS	denotes	spherules
T1584	5004-5013	VBP	denotes	establish
T1585	5014-5016	DT	denotes	an
T1587	5017-5029	VBG	denotes	invaginating
T1586	5030-5037	NN	denotes	synapse
T1588	5038-5042	IN	denotes	with
T1589	5043-5046	NN	denotes	rod
T1591	5047-5054	JJ	denotes	bipolar
T1590	5055-5064	NNS	denotes	dendrites
T1592	5065-5068	CC	denotes	and
T1593	5069-5075	JJ	denotes	axonal
T1594	5076-5083	NNS	denotes	endings
T1595	5084-5086	IN	denotes	of
T1596	5087-5097	JJ	denotes	horizontal
T1597	5098-5103	NNS	denotes	cells
T1598	5103-5104	.	denotes	.
T1599	5104-5192	sentence	denotes	This synapse is characterized by the presence of a ribbon in the presynaptic cytoplasm.
T1600	5105-5109	DT	denotes	This
T1601	5110-5117	NN	denotes	synapse
T1603	5118-5120	VBZ	denotes	is
T1602	5121-5134	VBN	denotes	characterized
T1604	5135-5137	IN	denotes	by
T1605	5138-5141	DT	denotes	the
T1606	5142-5150	NN	denotes	presence
T1607	5151-5153	IN	denotes	of
T1608	5154-5155	DT	denotes	a
T1609	5156-5162	NN	denotes	ribbon
T1610	5163-5165	IN	denotes	in
T1611	5166-5169	DT	denotes	the
T1613	5170-5181	JJ	denotes	presynaptic
T1612	5182-5191	NN	denotes	cytoplasm
T1614	5191-5192	.	denotes	.
T1615	5192-5364	sentence	denotes	Cone pedicles make invaginating synapses with the dendrites of on-cone bipolar cells and horizontal cells and basal junctions with the dendrites of off-cone bipolar cells.
T1616	5193-5197	NN	denotes	Cone
T1617	5198-5206	NNS	denotes	pedicles
T1618	5207-5211	VBP	denotes	make
T1619	5212-5224	VBG	denotes	invaginating
T1620	5225-5233	NNS	denotes	synapses
T1621	5234-5238	IN	denotes	with
T1622	5239-5242	DT	denotes	the
T1623	5243-5252	NNS	denotes	dendrites
T1624	5253-5255	IN	denotes	of
T1625	5256-5258	IN	denotes	on
T1627	5258-5259	HYPH	denotes	-
T1628	5259-5263	NN	denotes	cone
T1629	5264-5271	JJ	denotes	bipolar
T1626	5272-5277	NNS	denotes	cells
T1630	5278-5281	CC	denotes	and
T1631	5282-5292	JJ	denotes	horizontal
T1632	5293-5298	NNS	denotes	cells
T1633	5299-5302	CC	denotes	and
T1634	5303-5308	JJ	denotes	basal
T1635	5309-5318	NNS	denotes	junctions
T1636	5319-5323	IN	denotes	with
T1637	5324-5327	DT	denotes	the
T1638	5328-5337	NNS	denotes	dendrites
T1639	5338-5340	IN	denotes	of
T1640	5341-5344	IN	denotes	off
T1642	5344-5345	HYPH	denotes	-
T1643	5345-5349	NN	denotes	cone
T1644	5350-5357	JJ	denotes	bipolar
T1641	5358-5363	NNS	denotes	cells
T1645	5363-5364	.	denotes	.
T1646	5364-5455	sentence	denotes	The factors regulating the formation of the photoreceptor synapses are completely unknown.
T1647	5365-5368	DT	denotes	The
T1648	5369-5376	NNS	denotes	factors
T1650	5377-5387	VBG	denotes	regulating
T1651	5388-5391	DT	denotes	the
T1652	5392-5401	NN	denotes	formation
T1653	5402-5404	IN	denotes	of
T1654	5405-5408	DT	denotes	the
T1656	5409-5422	NN	denotes	photoreceptor
T1655	5423-5431	NNS	denotes	synapses
T1649	5432-5435	VBP	denotes	are
T1657	5436-5446	RB	denotes	completely
T1658	5447-5454	JJ	denotes	unknown
T1659	5454-5455	.	denotes	.
T1660	5455-5596	sentence	denotes	At least one photoreceptor synaptic protein, HRG4, contains a potential Crx target sequence in its transcriptional regulatory sequence [33].
T1661	5456-5458	RB	denotes	At
T1663	5459-5464	RBS	denotes	least
T1662	5465-5468	CD	denotes	one
T1665	5469-5482	NN	denotes	photoreceptor
T1666	5483-5491	JJ	denotes	synaptic
T1664	5492-5499	NN	denotes	protein
T1668	5499-5501	,	denotes	,
T1669	5501-5505	NN	denotes	HRG4
T1670	5505-5507	,	denotes	,
T1667	5507-5515	VBZ	denotes	contains
T1671	5516-5517	DT	denotes	a
T1673	5518-5527	JJ	denotes	potential
T1674	5528-5531	NN	denotes	Crx
T1675	5532-5538	NN	denotes	target
T1672	5539-5547	NN	denotes	sequence
T1676	5548-5550	IN	denotes	in
T1677	5551-5554	PRP$	denotes	its
T1679	5555-5570	JJ	denotes	transcriptional
T1680	5571-5581	JJ	denotes	regulatory
T1678	5582-5590	NN	denotes	sequence
T1681	5591-5592	-LRB-	denotes	[
T1682	5592-5594	CD	denotes	33
T1683	5594-5595	-RRB-	denotes	]
T1684	5595-5596	.	denotes	.
T1685	5596-5712	sentence	denotes	Few studies of LCA animal models have extended their examination of retinal pathology to the ultrastructural level.
T1686	5597-5600	JJ	denotes	Few
T1687	5601-5608	NNS	denotes	studies
T1689	5609-5611	IN	denotes	of
T1690	5612-5615	NN	denotes	LCA
T1692	5616-5622	NN	denotes	animal
T1691	5623-5629	NNS	denotes	models
T1693	5630-5634	VBP	denotes	have
T1688	5635-5643	VBN	denotes	extended
T1694	5644-5649	PRP$	denotes	their
T1695	5650-5661	NN	denotes	examination
T1696	5662-5664	IN	denotes	of
T1697	5665-5672	JJ	denotes	retinal
T1698	5673-5682	NN	denotes	pathology
T1699	5683-5685	IN	denotes	to
T1700	5686-5689	DT	denotes	the
T1702	5690-5705	JJ	denotes	ultrastructural
T1701	5706-5711	NN	denotes	level
T1703	5711-5712	.	denotes	.
T1704	5712-5841	sentence	denotes	Certain features of neuronal differentiation, such as synapse formation, can be detected definitively at this level of analysis.
T1705	5713-5720	JJ	denotes	Certain
T1706	5721-5729	NNS	denotes	features
T1708	5730-5732	IN	denotes	of
T1709	5733-5741	JJ	denotes	neuronal
T1710	5742-5757	NN	denotes	differentiation
T1711	5757-5759	,	denotes	,
T1712	5759-5763	JJ	denotes	such
T1713	5764-5766	IN	denotes	as
T1714	5767-5774	NN	denotes	synapse
T1715	5775-5784	NN	denotes	formation
T1716	5784-5786	,	denotes	,
T1717	5786-5789	MD	denotes	can
T1718	5790-5792	VB	denotes	be
T1707	5793-5801	VBN	denotes	detected
T1719	5802-5814	RB	denotes	definitively
T1720	5815-5817	IN	denotes	at
T1721	5818-5822	DT	denotes	this
T1722	5823-5828	NN	denotes	level
T1723	5829-5831	IN	denotes	of
T1724	5832-5840	NN	denotes	analysis
T1725	5840-5841	.	denotes	.
T1726	5841-6019	sentence	denotes	With the hope of understanding the neuropathology of LCA in greater detail, we have analyzed the differentiation of the outer retina in Crx-/- mice at the ultrastructural level.
T1727	5842-5846	IN	denotes	With
T1729	5847-5850	DT	denotes	the
T1730	5851-5855	NN	denotes	hope
T1731	5856-5858	IN	denotes	of
T1732	5859-5872	VBG	denotes	understanding
T1733	5873-5876	DT	denotes	the
T1734	5877-5891	NN	denotes	neuropathology
T1735	5892-5894	IN	denotes	of
T1736	5895-5898	NN	denotes	LCA
T1737	5899-5901	IN	denotes	in
T1738	5902-5909	JJR	denotes	greater
T1739	5910-5916	NN	denotes	detail
T1740	5916-5918	,	denotes	,
T1741	5918-5920	PRP	denotes	we
T1742	5921-5925	VBP	denotes	have
T1728	5926-5934	VBN	denotes	analyzed
T1743	5935-5938	DT	denotes	the
T1744	5939-5954	NN	denotes	differentiation
T1745	5955-5957	IN	denotes	of
T1746	5958-5961	DT	denotes	the
T1748	5962-5967	JJ	denotes	outer
T1747	5968-5974	NN	denotes	retina
T1749	5975-5977	IN	denotes	in
T1750	5978-5981	NN	denotes	Crx
T1752	5981-5982	SYM	denotes	-
T1753	5982-5983	HYPH	denotes	/
T1754	5983-5984	SYM	denotes	-
T1751	5985-5989	NNS	denotes	mice
T1755	5990-5992	IN	denotes	at
T1756	5993-5996	DT	denotes	the
T1758	5997-6012	JJ	denotes	ultrastructural
T1757	6013-6018	NN	denotes	level
T1759	6018-6019	.	denotes	.
T1760	6019-6068	sentence	denotes	These retinas exhibit several prominent defects.
T1761	6020-6025	DT	denotes	These
T1762	6026-6033	NNS	denotes	retinas
T1763	6034-6041	VBP	denotes	exhibit
T1764	6042-6049	JJ	denotes	several
T1766	6050-6059	JJ	denotes	prominent
T1765	6060-6067	NNS	denotes	defects
T1767	6067-6068	.	denotes	.
T1768	6068-6171	sentence	denotes	Crx-/- photoreceptors demonstrate a complete block in outer segment formation at the elongation stage.
T1769	6069-6072	NN	denotes	Crx
T1771	6072-6073	SYM	denotes	-
T1772	6073-6074	HYPH	denotes	/
T1773	6074-6075	SYM	denotes	-
T1770	6076-6090	NNS	denotes	photoreceptors
T1774	6091-6102	VBP	denotes	demonstrate
T1775	6103-6104	DT	denotes	a
T1777	6105-6113	JJ	denotes	complete
T1776	6114-6119	NN	denotes	block
T1778	6120-6122	IN	denotes	in
T1779	6123-6128	JJ	denotes	outer
T1780	6129-6136	NN	denotes	segment
T1781	6137-6146	NN	denotes	formation
T1782	6147-6149	IN	denotes	at
T1783	6150-6153	DT	denotes	the
T1785	6154-6164	NN	denotes	elongation
T1784	6165-6170	NN	denotes	stage
T1786	6170-6171	.	denotes	.
T1787	6171-6302	sentence	denotes	Further, these cells exhibit abnormal synaptic morphology, thereby broadening the function of Crx to photoreceptor synaptogenesis.
T1788	6172-6179	RB	denotes	Further
T1790	6179-6181	,	denotes	,
T1791	6181-6186	DT	denotes	these
T1792	6187-6192	NNS	denotes	cells
T1789	6193-6200	VBP	denotes	exhibit
T1793	6201-6209	JJ	denotes	abnormal
T1795	6210-6218	JJ	denotes	synaptic
T1794	6219-6229	NN	denotes	morphology
T1796	6229-6231	,	denotes	,
T1797	6231-6238	RB	denotes	thereby
T1798	6239-6249	VBG	denotes	broadening
T1799	6250-6253	DT	denotes	the
T1800	6254-6262	NN	denotes	function
T1801	6263-6265	IN	denotes	of
T1802	6266-6269	NN	denotes	Crx
T1803	6270-6272	IN	denotes	to
T1804	6273-6286	NN	denotes	photoreceptor
T1805	6287-6301	NN	denotes	synaptogenesis
T1806	6301-6302	.	denotes	.
T1807	6302-6397	sentence	denotes	This represents the first report strongly implicating the process of synapse formation in LCA.
T1808	6303-6307	DT	denotes	This
T1809	6308-6318	VBZ	denotes	represents
T1810	6319-6322	DT	denotes	the
T1812	6323-6328	JJ	denotes	first
T1811	6329-6335	NN	denotes	report
T1813	6336-6344	RB	denotes	strongly
T1814	6345-6356	VBG	denotes	implicating
T1815	6357-6360	DT	denotes	the
T1816	6361-6368	NN	denotes	process
T1817	6369-6371	IN	denotes	of
T1818	6372-6379	NN	denotes	synapse
T1819	6380-6389	NN	denotes	formation
T1820	6390-6392	IN	denotes	in
T1821	6393-6396	NN	denotes	LCA
T1822	6396-6397	.	denotes	.
T2359	6408-6416	JJ	denotes	Multiple
T2360	6417-6428	NNS	denotes	pathologies
T2361	6429-6431	IN	denotes	in
T2362	6432-6435	DT	denotes	the
T2364	6436-6441	JJ	denotes	outer
T2365	6442-6449	NN	denotes	segment
T2363	6450-6455	NN	denotes	layer
T2366	6456-6458	IN	denotes	in
T2367	6459-6462	NN	denotes	Crx
T2369	6462-6463	SYM	denotes	-
T2370	6463-6464	HYPH	denotes	/
T2371	6464-6465	SYM	denotes	-
T2368	6466-6470	NNS	denotes	mice
T2372	6470-6587	sentence	denotes	A standard knock-out protocol was used to generate mice in which the homeodomain of Crx-/- was targeted and deleted.
T2373	6471-6472	DT	denotes	A
T2375	6473-6481	JJ	denotes	standard
T2376	6482-6487	VB	denotes	knock
T2377	6487-6488	HYPH	denotes	-
T2378	6488-6491	RP	denotes	out
T2374	6492-6500	NN	denotes	protocol
T2380	6501-6504	VBD	denotes	was
T2379	6505-6509	VBN	denotes	used
T2381	6510-6512	TO	denotes	to
T2382	6513-6521	VB	denotes	generate
T2383	6522-6526	NNS	denotes	mice
T2384	6527-6529	IN	denotes	in
T2386	6530-6535	WDT	denotes	which
T2387	6536-6539	DT	denotes	the
T2388	6540-6551	NN	denotes	homeodomain
T2389	6552-6554	IN	denotes	of
T2390	6555-6558	NN	denotes	Crx
T2391	6558-6559	SYM	denotes	-
T2392	6559-6560	HYPH	denotes	/
T2393	6560-6561	SYM	denotes	-
T2394	6562-6565	VBD	denotes	was
T2385	6566-6574	VBN	denotes	targeted
T2395	6575-6578	CC	denotes	and
T2396	6579-6586	VBN	denotes	deleted
T2397	6586-6587	.	denotes	.
T2398	6587-6653	sentence	denotes	Generation of these Crx-/- mice has been reported elsewhere [34].
T2399	6588-6598	NN	denotes	Generation
T2401	6599-6601	IN	denotes	of
T2402	6602-6607	DT	denotes	these
T2404	6608-6611	NN	denotes	Crx
T2405	6611-6612	SYM	denotes	-
T2406	6612-6613	HYPH	denotes	/
T2407	6613-6614	SYM	denotes	-
T2403	6615-6619	NNS	denotes	mice
T2408	6620-6623	VBZ	denotes	has
T2409	6624-6628	VBN	denotes	been
T2400	6629-6637	VBN	denotes	reported
T2410	6638-6647	RB	denotes	elsewhere
T2411	6648-6649	-LRB-	denotes	[
T2412	6649-6651	CD	denotes	34
T2413	6651-6652	-RRB-	denotes	]
T2414	6652-6653	.	denotes	.
T2415	6653-6838	sentence	denotes	In this study, in order to characterize further the role of Crx in photoreceptor morphogenesis, the outer retinae from Crx-/- mice were examined using transmission electron microscopy.
T2416	6654-6656	IN	denotes	In
T2418	6657-6661	DT	denotes	this
T2419	6662-6667	NN	denotes	study
T2420	6667-6669	,	denotes	,
T2421	6669-6671	IN	denotes	in
T2422	6672-6677	NN	denotes	order
T2423	6678-6680	TO	denotes	to
T2424	6681-6693	VB	denotes	characterize
T2425	6694-6701	RB	denotes	further
T2426	6702-6705	DT	denotes	the
T2427	6706-6710	NN	denotes	role
T2428	6711-6713	IN	denotes	of
T2429	6714-6717	NN	denotes	Crx
T2430	6718-6720	IN	denotes	in
T2431	6721-6734	NN	denotes	photoreceptor
T2432	6735-6748	NN	denotes	morphogenesis
T2433	6748-6750	,	denotes	,
T2434	6750-6753	DT	denotes	the
T2436	6754-6759	JJ	denotes	outer
T2435	6760-6767	NNS	denotes	retinae
T2437	6768-6772	IN	denotes	from
T2438	6773-6776	NN	denotes	Crx
T2440	6776-6777	SYM	denotes	-
T2441	6777-6778	HYPH	denotes	/
T2442	6778-6779	SYM	denotes	-
T2439	6780-6784	NNS	denotes	mice
T2443	6785-6789	VBD	denotes	were
T2417	6790-6798	VBN	denotes	examined
T2444	6799-6804	VBG	denotes	using
T2445	6805-6817	NN	denotes	transmission
T2447	6818-6826	NN	denotes	electron
T2446	6827-6837	NN	denotes	microscopy
T2448	6837-6838	.	denotes	.
T2449	6838-7017	sentence	denotes	At postnatal day 21 (P21), when Crx+/+ photoreceptors exhibited robust outer segments (Figure 1A, os), Crx-/- retinas were without a recognizable outer segment layer (Figure 1B).
T2450	6839-6841	IN	denotes	At
T2452	6842-6851	JJ	denotes	postnatal
T2453	6852-6855	NN	denotes	day
T2454	6856-6858	CD	denotes	21
T2455	6859-6860	-LRB-	denotes	(
T2456	6860-6863	NN	denotes	P21
T2457	6863-6864	-RRB-	denotes	)
T2458	6864-6866	,	denotes	,
T2459	6866-6870	WRB	denotes	when
T2461	6871-6874	NN	denotes	Crx
T2463	6874-6875	SYM	denotes	+
T2464	6875-6876	HYPH	denotes	/
T2465	6876-6877	SYM	denotes	+
T2462	6878-6892	NNS	denotes	photoreceptors
T2460	6893-6902	VBD	denotes	exhibited
T2466	6903-6909	JJ	denotes	robust
T2468	6910-6915	JJ	denotes	outer
T2467	6916-6924	NNS	denotes	segments
T2469	6925-6926	-LRB-	denotes	(
T2471	6926-6932	NN	denotes	Figure
T2472	6933-6935	NN	denotes	1A
T2473	6935-6937	,	denotes	,
T2470	6937-6939	NN	denotes	os
T2474	6939-6940	-RRB-	denotes	)
T2475	6940-6942	,	denotes	,
T2476	6942-6945	NN	denotes	Crx
T2478	6945-6946	SYM	denotes	-
T2479	6946-6947	HYPH	denotes	/
T2480	6947-6948	SYM	denotes	-
T2477	6949-6956	NNS	denotes	retinas
T2451	6957-6961	VBD	denotes	were
T2481	6962-6969	IN	denotes	without
T2482	6970-6971	DT	denotes	a
T2484	6972-6984	JJ	denotes	recognizable
T2485	6985-6990	JJ	denotes	outer
T2486	6991-6998	NN	denotes	segment
T2483	6999-7004	NN	denotes	layer
T2487	7005-7006	-LRB-	denotes	(
T2488	7006-7012	NN	denotes	Figure
T2489	7013-7015	CD	denotes	1B
T2490	7015-7016	-RRB-	denotes	)
T2491	7016-7017	.	denotes	.
T2492	7017-7192	sentence	denotes	Crx-/- photoreceptors had inner segments, demonstrating at least limited photoreceptor polarization in the Crx mutant, but the inner segments were extremely short (Figure 2).
T2493	7018-7021	NN	denotes	Crx
T2495	7021-7022	SYM	denotes	-
T2496	7022-7023	HYPH	denotes	/
T2497	7023-7024	SYM	denotes	-
T2494	7025-7039	NNS	denotes	photoreceptors
T2498	7040-7043	VBD	denotes	had
T2499	7044-7049	JJ	denotes	inner
T2500	7050-7058	NNS	denotes	segments
T2501	7058-7060	,	denotes	,
T2502	7060-7073	VBG	denotes	demonstrating
T2503	7074-7076	RB	denotes	at
T2504	7077-7082	RBS	denotes	least
T2505	7083-7090	JJ	denotes	limited
T2507	7091-7104	NN	denotes	photoreceptor
T2506	7105-7117	NN	denotes	polarization
T2508	7118-7120	IN	denotes	in
T2509	7121-7124	DT	denotes	the
T2511	7125-7128	NN	denotes	Crx
T2510	7129-7135	NN	denotes	mutant
T2512	7135-7137	,	denotes	,
T2513	7137-7140	CC	denotes	but
T2514	7141-7144	DT	denotes	the
T2516	7145-7150	JJ	denotes	inner
T2515	7151-7159	NNS	denotes	segments
T2517	7160-7164	VBD	denotes	were
T2518	7165-7174	RB	denotes	extremely
T2519	7175-7180	JJ	denotes	short
T2520	7181-7182	-LRB-	denotes	(
T2521	7182-7188	NN	denotes	Figure
T2522	7189-7190	CD	denotes	2
T2523	7190-7191	-RRB-	denotes	)
T2524	7191-7192	.	denotes	.
T2525	7192-7354	sentence	denotes	Furthermore, the majority of inner segments showed some morphological differentiation, having approximately as many mitochondria as the control (Figure 1 and 2).
T2526	7193-7204	RB	denotes	Furthermore
T2528	7204-7206	,	denotes	,
T2529	7206-7209	DT	denotes	the
T2530	7210-7218	NN	denotes	majority
T2531	7219-7221	IN	denotes	of
T2532	7222-7227	JJ	denotes	inner
T2533	7228-7236	NNS	denotes	segments
T2527	7237-7243	VBD	denotes	showed
T2534	7244-7248	DT	denotes	some
T2536	7249-7262	JJ	denotes	morphological
T2535	7263-7278	NN	denotes	differentiation
T2537	7278-7280	,	denotes	,
T2538	7280-7286	VBG	denotes	having
T2539	7287-7300	RB	denotes	approximately
T2541	7301-7303	RB	denotes	as
T2540	7304-7308	JJ	denotes	many
T2542	7309-7321	NNS	denotes	mitochondria
T2543	7322-7324	IN	denotes	as
T2544	7325-7328	DT	denotes	the
T2545	7329-7336	NN	denotes	control
T2546	7337-7338	-LRB-	denotes	(
T2548	7338-7344	NN	denotes	Figure
T2547	7345-7346	CD	denotes	1
T2549	7347-7350	CC	denotes	and
T2550	7351-7352	CD	denotes	2
T2551	7352-7353	-RRB-	denotes	)
T2552	7353-7354	.	denotes	.
T2553	7354-7491	sentence	denotes	Occasionally, an inner segment undergoing lysis was noted, appearing swollen or with vacuoles and swollen mitochondria (data not shown).
T2554	7355-7367	RB	denotes	Occasionally
T2556	7367-7369	,	denotes	,
T2557	7369-7371	DT	denotes	an
T2559	7372-7377	JJ	denotes	inner
T2558	7378-7385	NN	denotes	segment
T2560	7386-7396	VBG	denotes	undergoing
T2561	7397-7402	NN	denotes	lysis
T2562	7403-7406	VBD	denotes	was
T2555	7407-7412	VBN	denotes	noted
T2563	7412-7414	,	denotes	,
T2564	7414-7423	VBG	denotes	appearing
T2565	7424-7431	VBN	denotes	swollen
T2566	7432-7434	CC	denotes	or
T2567	7435-7439	IN	denotes	with
T2568	7440-7448	NNS	denotes	vacuoles
T2569	7449-7452	CC	denotes	and
T2570	7453-7460	VBN	denotes	swollen
T2571	7461-7473	NNS	denotes	mitochondria
T2572	7474-7475	-LRB-	denotes	(
T2574	7475-7479	NNS	denotes	data
T2575	7480-7483	RB	denotes	not
T2573	7484-7489	VBN	denotes	shown
T2576	7489-7490	-RRB-	denotes	)
T2577	7490-7491	.	denotes	.
T2578	7491-7492	sentence	denotes
T8250	7502-7514	NN	denotes	Transmission
T8252	7515-7523	NN	denotes	electron
T8251	7524-7534	NN	denotes	microscopy
T8253	7535-7537	IN	denotes	of
T8254	7538-7541	DT	denotes	the
T8256	7542-7547	JJ	denotes	outer
T8255	7548-7554	NN	denotes	retina
T8257	7555-7557	IN	denotes	at
T8258	7558-7561	NN	denotes	P21
T8259	7562-7564	IN	denotes	in
T8260	7565-7566	-LRB-	denotes	(
T8261	7566-7567	LS	denotes	A
T8263	7567-7568	-RRB-	denotes	)
T8262	7569-7572	NN	denotes	Crx
T8265	7572-7573	SYM	denotes	+
T8266	7573-7574	HYPH	denotes	/
T8267	7574-7575	SYM	denotes	+
T8268	7576-7579	CC	denotes	and
T8269	7580-7581	-LRB-	denotes	(
T8270	7581-7582	LS	denotes	B
T8272	7582-7583	-RRB-	denotes	)
T8271	7584-7587	NN	denotes	Crx
T8273	7587-7588	SYM	denotes	-
T8274	7588-7589	HYPH	denotes	/
T8275	7589-7590	SYM	denotes	-
T8264	7591-7598	NNS	denotes	retinas
T8276	7598-7599	.	denotes	.
T8277	7599-7625	sentence	denotes	pe, pigmented epithelium.
T8278	7600-7602	NN	denotes	pe
T8279	7602-7604	,	denotes	,
T8280	7604-7613	JJ	denotes	pigmented
T8281	7614-7624	NN	denotes	epithelium
T8282	7624-7625	.	denotes	.
T8283	7625-7645	sentence	denotes	os, outer segments.
T8284	7626-7628	NN	denotes	os
T8285	7628-7630	,	denotes	,
T8286	7630-7635	JJ	denotes	outer
T8287	7636-7644	NNS	denotes	segments
T8288	7644-7645	.	denotes	.
T8289	7645-7665	sentence	denotes	is, inner segments.
T8290	7646-7648	NN	denotes	is
T8291	7648-7650	,	denotes	,
T8292	7650-7655	JJ	denotes	inner
T8293	7656-7664	NNS	denotes	segments
T8294	7664-7665	.	denotes	.
T8295	7665-7717	sentence	denotes	onl, outer nuclear layer with photoreceptor nuclei.
T8296	7666-7669	NN	denotes	onl
T8297	7669-7671	,	denotes	,
T8298	7671-7676	JJ	denotes	outer
T8300	7677-7684	JJ	denotes	nuclear
T8299	7685-7690	NN	denotes	layer
T8301	7691-7695	IN	denotes	with
T8302	7696-7709	NN	denotes	photoreceptor
T8303	7710-7716	NNS	denotes	nuclei
T8304	7716-7717	.	denotes	.
T8305	7717-7747	sentence	denotes	Scale bar = 5 μm for A and B.
T8306	7718-7723	NN	denotes	Scale
T8307	7724-7727	NN	denotes	bar
T8309	7728-7729	SYM	denotes	=
T8310	7730-7731	CD	denotes	5
T8308	7732-7734	NN	denotes	μm
T8311	7735-7738	IN	denotes	for
T8312	7739-7740	NN	denotes	A
T8313	7741-7744	CC	denotes	and
T8314	7745-7746	NN	denotes	B
T8315	7746-7747	.	denotes	.
T8372	7758-7770	NN	denotes	Transmission
T8374	7771-7779	NN	denotes	electron
T8373	7780-7790	NN	denotes	micrograph
T8375	7791-7793	IN	denotes	of
T8376	7794-7797	DT	denotes	the
T8378	7798-7803	JJ	denotes	outer
T8379	7804-7811	NN	denotes	segment
T8377	7812-7817	NN	denotes	layer
T8380	7818-7820	IN	denotes	of
T8381	7821-7824	NN	denotes	Crx
T8383	7824-7825	SYM	denotes	-
T8384	7825-7826	HYPH	denotes	/
T8385	7826-7827	SYM	denotes	-
T8382	7828-7834	NN	denotes	retina
T8386	7835-7837	IN	denotes	at
T8387	7838-7841	NN	denotes	P21
T8388	7841-7842	.	denotes	.
T8389	7842-7961	sentence	denotes	Inner segments of Crx-/- photoreceptors exhibit numerous mitochondria (m indicated by arrow) as in Crx+/+ (Figure 1A).
T8390	7843-7848	JJ	denotes	Inner
T8391	7849-7857	NNS	denotes	segments
T8393	7858-7860	IN	denotes	of
T8394	7861-7864	NN	denotes	Crx
T8396	7864-7865	SYM	denotes	-
T8397	7865-7866	HYPH	denotes	/
T8398	7866-7867	SYM	denotes	-
T8395	7868-7882	NNS	denotes	photoreceptors
T8392	7883-7890	VBP	denotes	exhibit
T8399	7891-7899	JJ	denotes	numerous
T8400	7900-7912	NNS	denotes	mitochondria
T8401	7913-7914	-LRB-	denotes	(
T8403	7914-7915	NN	denotes	m
T8402	7916-7925	VBN	denotes	indicated
T8404	7926-7928	IN	denotes	by
T8405	7929-7934	NN	denotes	arrow
T8406	7934-7935	-RRB-	denotes	)
T8407	7936-7938	IN	denotes	as
T8408	7939-7941	IN	denotes	in
T8409	7942-7945	NN	denotes	Crx
T8410	7945-7946	SYM	denotes	+
T8411	7946-7947	HYPH	denotes	/
T8412	7947-7948	SYM	denotes	+
T8413	7949-7950	-LRB-	denotes	(
T8414	7950-7956	NN	denotes	Figure
T8415	7957-7959	CD	denotes	1A
T8416	7959-7960	-RRB-	denotes	)
T8417	7960-7961	.	denotes	.
T8418	7961-7987	sentence	denotes	pe, pigmented epithelium.
T8419	7962-7964	NN	denotes	pe
T8420	7964-7966	,	denotes	,
T8421	7966-7975	JJ	denotes	pigmented
T8422	7976-7986	NN	denotes	epithelium
T8423	7986-7987	.	denotes	.
T8424	7987-8007	sentence	denotes	is, inner segments.
T8425	7988-7990	NN	denotes	is
T8426	7990-7992	,	denotes	,
T8427	7992-7997	JJ	denotes	inner
T8428	7998-8006	NNS	denotes	segments
T8429	8006-8007	.	denotes	.
T8430	8007-8033	sentence	denotes	onl, outer nuclear layer.
T8431	8008-8011	NN	denotes	onl
T8432	8011-8013	,	denotes	,
T8433	8013-8018	JJ	denotes	outer
T8435	8019-8026	JJ	denotes	nuclear
T8434	8027-8032	NN	denotes	layer
T8436	8032-8033	.	denotes	.
T8437	8033-8051	sentence	denotes	Scale bar = 2 μm.
T8438	8034-8039	NN	denotes	Scale
T8439	8040-8043	NN	denotes	bar
T8441	8044-8045	SYM	denotes	=
T8442	8046-8047	CD	denotes	2
T8440	8048-8050	NN	denotes	μm
T8443	8050-8051	.	denotes	.
T2579	8052-8053	sentence	denotes	P
T2580	8052-8053	NN	denotes	P
T2581	8053-8054	sentence	denotes	h
T2582	8053-8054	NN	denotes	h
T2584	8054-8055	NN	denotes	o
T2583	8054-8056	sentence	denotes	ot
T2585	8055-8056	JJ	denotes	t
T2587	8056-8057	NN	denotes	o
T2586	8056-8067	sentence	denotes	oreceptor i
T2588	8057-8058	JJ	denotes	r
T2589	8058-8059	JJ	denotes	e
T2590	8059-8065	NN	denotes	ceptor
T2591	8066-8067	NNS	denotes	i
T2592	8067-8068	sentence	denotes	n
T2593	8067-8068	CC	denotes	n
T2595	8068-8069	NN	denotes	n
T2594	8068-8079	sentence	denotes	ner segment
T2596	8069-8071	NN	denotes	er
T2597	8072-8079	NN	denotes	segment
T2599	8079-8080	NNS	denotes	s
T2598	8079-8087	sentence	denotes	s and ou
T2600	8081-8082	NNS	denotes	a
T2601	8082-8084	VBN	denotes	nd
T2602	8085-8086	NN	denotes	o
T2603	8086-8087	NN	denotes	u
T2604	8087-8089	sentence	denotes	te
T2605	8087-8089	JJ	denotes	te
T2607	8089-8090	JJ	denotes	r
T2606	8089-8099	sentence	denotes	r segments
T2608	8091-8099	NNS	denotes	segments
T2609	8099-8103	sentence	denotes	are
T2611	8100-8102	JJ	denotes	ar
T2610	8102-8103	NN	denotes	e
T2612	8103-8104	sentence	denotes
T2614	8104-8110	VBN	denotes	joined
T2613	8104-8247	sentence	denotes	joined by a non-motile connecting cilium that exhibits a characteristic 9 + 0 arrangement of microtubule doublets when viewed in cross-section.
T2615	8111-8113	IN	denotes	by
T2616	8114-8115	DT	denotes	a
T2618	8116-8126	JJ	denotes	non-motile
T2619	8127-8137	JJ	denotes	connecting
T2617	8138-8144	NN	denotes	cilium
T2620	8145-8149	WDT	denotes	that
T2621	8150-8158	VBZ	denotes	exhibits
T2622	8159-8160	DT	denotes	a
T2624	8161-8175	JJ	denotes	characteristic
T2625	8176-8177	CD	denotes	9
T2627	8178-8179	SYM	denotes	+
T2626	8180-8181	CD	denotes	0
T2623	8182-8193	NN	denotes	arrangement
T2628	8194-8196	IN	denotes	of
T2629	8197-8208	NN	denotes	microtubule
T2630	8209-8217	NNS	denotes	doublets
T2631	8218-8222	WRB	denotes	when
T2632	8223-8229	VBN	denotes	viewed
T2633	8230-8232	IN	denotes	in
T2634	8233-8246	NN	denotes	cross-section
T2635	8246-8247	.	denotes	.
T2636	8247-8349	sentence	denotes	At P21, in Crx-/- retinas, numerous cross sections of connecting cilia were noted (Figure 3A and 3B).
T2637	8248-8250	IN	denotes	At
T2639	8251-8254	NN	denotes	P21
T2640	8254-8256	,	denotes	,
T2641	8256-8258	IN	denotes	in
T2642	8259-8262	NN	denotes	Crx
T2644	8262-8263	SYM	denotes	-
T2645	8263-8264	HYPH	denotes	/
T2646	8264-8265	SYM	denotes	-
T2643	8266-8273	NNS	denotes	retinas
T2647	8273-8275	,	denotes	,
T2648	8275-8283	JJ	denotes	numerous
T2650	8284-8289	NN	denotes	cross
T2649	8290-8298	NNS	denotes	sections
T2651	8299-8301	IN	denotes	of
T2652	8302-8312	JJ	denotes	connecting
T2653	8313-8318	NNS	denotes	cilia
T2654	8319-8323	VBD	denotes	were
T2638	8324-8329	VBN	denotes	noted
T2655	8330-8331	-LRB-	denotes	(
T2657	8331-8337	NN	denotes	Figure
T2656	8338-8340	CD	denotes	3A
T2658	8341-8344	CC	denotes	and
T2659	8345-8347	CD	denotes	3B
T2660	8347-8348	-RRB-	denotes	)
T2661	8348-8349	.	denotes	.
T2662	8349-8449	sentence	denotes	Sporadically, connecting cilia contained other than the typical complement of microtubule doublets.
T2663	8350-8362	RB	denotes	Sporadically
T2665	8362-8364	,	denotes	,
T2666	8364-8374	JJ	denotes	connecting
T2667	8375-8380	NNS	denotes	cilia
T2664	8381-8390	VBD	denotes	contained
T2668	8391-8396	JJ	denotes	other
T2669	8397-8401	IN	denotes	than
T2670	8402-8405	DT	denotes	the
T2672	8406-8413	JJ	denotes	typical
T2671	8414-8424	NN	denotes	complement
T2673	8425-8427	IN	denotes	of
T2674	8428-8439	NN	denotes	microtubule
T2675	8440-8448	NNS	denotes	doublets
T2676	8448-8449	.	denotes	.
T2677	8449-8545	sentence	denotes	For example, in Figure 3A, the connecting cilium labelled by arrowhead 1, shows 7 + 0 doublets.
T2678	8450-8453	IN	denotes	For
T2680	8454-8461	NN	denotes	example
T2681	8461-8463	,	denotes	,
T2682	8463-8465	IN	denotes	in
T2683	8466-8472	NN	denotes	Figure
T2684	8473-8475	NN	denotes	3A
T2685	8475-8477	,	denotes	,
T2686	8477-8480	DT	denotes	the
T2688	8481-8491	JJ	denotes	connecting
T2687	8492-8498	NN	denotes	cilium
T2689	8499-8507	VBN	denotes	labelled
T2690	8508-8510	IN	denotes	by
T2691	8511-8520	NN	denotes	arrowhead
T2692	8521-8522	CD	denotes	1
T2693	8522-8524	,	denotes	,
T2679	8524-8529	VBZ	denotes	shows
T2694	8530-8531	CD	denotes	7
T2696	8532-8533	SYM	denotes	+
T2695	8534-8535	CD	denotes	0
T2697	8536-8544	NNS	denotes	doublets
T2698	8544-8545	.	denotes	.
T2699	8545-8650	sentence	denotes	The majority exhibited the characteristic 9 + 0 doublets (arrowhead 2 and 3 in Figure 3A and Figure 3B).
T2700	8546-8549	DT	denotes	The
T2701	8550-8558	NN	denotes	majority
T2702	8559-8568	VBD	denotes	exhibited
T2703	8569-8572	DT	denotes	the
T2705	8573-8587	JJ	denotes	characteristic
T2706	8588-8589	CD	denotes	9
T2708	8590-8591	SYM	denotes	+
T2707	8592-8593	CD	denotes	0
T2704	8594-8602	NNS	denotes	doublets
T2709	8603-8604	-LRB-	denotes	(
T2711	8604-8613	NN	denotes	arrowhead
T2710	8614-8615	CD	denotes	2
T2712	8616-8619	CC	denotes	and
T2713	8620-8621	CD	denotes	3
T2714	8622-8624	IN	denotes	in
T2715	8625-8631	NN	denotes	Figure
T2716	8632-8634	NN	denotes	3A
T2717	8635-8638	CC	denotes	and
T2718	8639-8645	NN	denotes	Figure
T2719	8646-8648	NN	denotes	3B
T2720	8648-8649	-RRB-	denotes	)
T2721	8649-8650	.	denotes	.
T2722	8650-8785	sentence	denotes	These observations indicate that in addition to inner segment formation, ciliogenesis is also largely intact in Crx-/- photoreceptors.
T2723	8651-8656	DT	denotes	These
T2724	8657-8669	NNS	denotes	observations
T2725	8670-8678	VBP	denotes	indicate
T2726	8679-8683	IN	denotes	that
T2728	8684-8686	IN	denotes	in
T2729	8687-8695	NN	denotes	addition
T2730	8696-8698	IN	denotes	to
T2731	8699-8704	JJ	denotes	inner
T2732	8705-8712	NN	denotes	segment
T2733	8713-8722	NN	denotes	formation
T2734	8722-8724	,	denotes	,
T2735	8724-8736	NN	denotes	ciliogenesis
T2727	8737-8739	VBZ	denotes	is
T2736	8740-8744	RB	denotes	also
T2737	8745-8752	RB	denotes	largely
T2738	8753-8759	JJ	denotes	intact
T2739	8760-8762	IN	denotes	in
T2740	8763-8766	NN	denotes	Crx
T2742	8766-8767	SYM	denotes	-
T2743	8767-8768	HYPH	denotes	/
T2744	8768-8769	SYM	denotes	-
T2741	8770-8784	NNS	denotes	photoreceptors
T2745	8784-8785	.	denotes	.
T2746	8785-8929	sentence	denotes	Further, in Crx-/- retinas the retinal pigmented epithelium (PE) appeared normal, at least up to P21 (data not shown), the oldest age examined.
T2747	8786-8793	RB	denotes	Further
T2749	8793-8795	,	denotes	,
T2750	8795-8797	IN	denotes	in
T2751	8798-8801	NN	denotes	Crx
T2753	8801-8802	SYM	denotes	-
T2754	8802-8803	HYPH	denotes	/
T2755	8803-8804	SYM	denotes	-
T2752	8805-8812	NNS	denotes	retinas
T2756	8813-8816	DT	denotes	the
T2758	8817-8824	NN	denotes	retinal
T2759	8825-8834	VBN	denotes	pigmented
T2757	8835-8845	NN	denotes	epithelium
T2760	8846-8847	-LRB-	denotes	(
T2761	8847-8849	NN	denotes	PE
T2762	8849-8850	-RRB-	denotes	)
T2748	8851-8859	VBD	denotes	appeared
T2763	8860-8866	JJ	denotes	normal
T2764	8866-8868	,	denotes	,
T2765	8868-8870	RB	denotes	at
T2766	8871-8876	RBS	denotes	least
T2767	8877-8879	IN	denotes	up
T2768	8880-8882	IN	denotes	to
T2769	8883-8886	NN	denotes	P21
T2770	8887-8888	-LRB-	denotes	(
T2772	8888-8892	NNS	denotes	data
T2773	8893-8896	RB	denotes	not
T2771	8897-8902	VBN	denotes	shown
T2774	8902-8903	-RRB-	denotes	)
T2775	8903-8905	,	denotes	,
T2776	8905-8908	DT	denotes	the
T2778	8909-8915	JJS	denotes	oldest
T2777	8916-8919	NN	denotes	age
T2779	8920-8928	VBN	denotes	examined
T2780	8928-8929	.	denotes	.
T2781	8929-8930	sentence	denotes
T8570	8940-8952	NN	denotes	Transmission
T8572	8953-8961	NN	denotes	electron
T8571	8962-8972	NN	denotes	micrograph
T8573	8973-8975	IN	denotes	of
T8574	8976-8979	NN	denotes	Crx
T8576	8979-8980	SYM	denotes	-
T8577	8980-8981	HYPH	denotes	/
T8578	8981-8982	SYM	denotes	-
T8575	8983-8989	NN	denotes	retina
T8579	8990-8992	IN	denotes	at
T8580	8993-8996	NN	denotes	P21
T8581	8997-8998	-LRB-	denotes	(
T8582	8998-8999	NN	denotes	A
T8583	9000-9003	CC	denotes	and
T8584	9004-9005	NN	denotes	B
T8585	9005-9006	-RRB-	denotes	)
T8586	9006-9008	,	denotes	,
T8587	9008-9011	CC	denotes	and
T8588	9012-9020	VBG	denotes	scanning
T8590	9021-9029	NN	denotes	electron
T8589	9030-9040	NN	denotes	micrograph
T8591	9041-9043	IN	denotes	of
T8592	9044-9047	NN	denotes	Crx
T8593	9047-9048	SYM	denotes	-
T8594	9048-9049	HYPH	denotes	/
T8595	9049-9050	SYM	denotes	-
T8596	9051-9053	IN	denotes	at
T8597	9054-9057	NN	denotes	P10
T8598	9058-9059	-LRB-	denotes	(
T8599	9059-9060	NN	denotes	C
T8600	9060-9061	-RRB-	denotes	)
T8601	9062-9064	IN	denotes	of
T8602	9065-9070	JJ	denotes	outer
T8603	9071-9078	NN	denotes	segment
T8604	9079-9084	NN	denotes	layer
T8605	9084-9085	.	denotes	.
T8606	9085-9159	sentence	denotes	(A) Evidence of ciliogenesis in the photoreceptor layer of Crx-/- retina.
T8607	9086-9087	-LRB-	denotes	(
T8608	9087-9088	LS	denotes	A
T8610	9088-9089	-RRB-	denotes	)
T8609	9090-9098	NN	denotes	Evidence
T8611	9099-9101	IN	denotes	of
T8612	9102-9114	NN	denotes	ciliogenesis
T8613	9115-9117	IN	denotes	in
T8614	9118-9121	DT	denotes	the
T8616	9122-9135	NN	denotes	photoreceptor
T8615	9136-9141	NN	denotes	layer
T8617	9142-9144	IN	denotes	of
T8618	9145-9148	NN	denotes	Crx
T8620	9148-9149	SYM	denotes	-
T8621	9149-9150	HYPH	denotes	/
T8622	9150-9151	SYM	denotes	-
T8619	9152-9158	NN	denotes	retina
T8623	9158-9159	.	denotes	.
T8624	9159-9256	sentence	denotes	Nonmotile connecting cilia were observed in cross section (arrowheads 1,2, and 3, for examples).
T8625	9160-9169	JJ	denotes	Nonmotile
T8627	9170-9180	VBG	denotes	connecting
T8626	9181-9186	NNS	denotes	cilia
T8629	9187-9191	VBD	denotes	were
T8628	9192-9200	VBN	denotes	observed
T8630	9201-9203	IN	denotes	in
T8631	9204-9209	NN	denotes	cross
T8632	9210-9217	NN	denotes	section
T8633	9218-9219	-LRB-	denotes	(
T8635	9219-9229	NNS	denotes	arrowheads
T8634	9230-9231	CD	denotes	1
T8636	9231-9232	,	denotes	,
T8637	9232-9233	CD	denotes	2
T8638	9233-9235	,	denotes	,
T8639	9235-9238	CC	denotes	and
T8640	9239-9240	CD	denotes	3
T8641	9240-9242	,	denotes	,
T8642	9242-9245	IN	denotes	for
T8643	9246-9254	NNS	denotes	examples
T8644	9254-9255	-RRB-	denotes	)
T8645	9255-9256	.	denotes	.
T8646	9256-9374	sentence	denotes	Connecting cilium 1 (arrowhead 1) demonstrated seven microtuble doublets, while cilium 2 and cilium 3 exhibited nine.
T8647	9257-9267	VBG	denotes	Connecting
T8648	9268-9274	NN	denotes	cilium
T8650	9275-9276	CD	denotes	1
T8651	9277-9278	-LRB-	denotes	(
T8652	9278-9287	NN	denotes	arrowhead
T8653	9288-9289	CD	denotes	1
T8654	9289-9290	-RRB-	denotes	)
T8649	9291-9303	VBD	denotes	demonstrated
T8655	9304-9309	CD	denotes	seven
T8657	9310-9320	JJ	denotes	microtuble
T8656	9321-9329	NNS	denotes	doublets
T8658	9329-9331	,	denotes	,
T8659	9331-9336	IN	denotes	while
T8661	9337-9343	NN	denotes	cilium
T8662	9344-9345	CD	denotes	2
T8663	9346-9349	CC	denotes	and
T8664	9350-9356	NN	denotes	cilium
T8665	9357-9358	CD	denotes	3
T8660	9359-9368	VBD	denotes	exhibited
T8666	9369-9373	CD	denotes	nine
T8667	9373-9374	.	denotes	.
T8668	9374-9649	sentence	denotes	In A, a displaced cell nucleus (n) appearing pyknotic and abnormal deposition of matrix (mx) material of unknown identity were seen, along with large amounts of membranous vesicles (arrow) which filled the photoreceptor space and appeared to be released from inner segments.
T8669	9375-9377	IN	denotes	In
T8671	9378-9379	NN	denotes	A
T8672	9379-9381	,	denotes	,
T8673	9381-9382	DT	denotes	a
T8675	9383-9392	VBN	denotes	displaced
T8676	9393-9397	NN	denotes	cell
T8674	9398-9405	NN	denotes	nucleus
T8677	9406-9407	-LRB-	denotes	(
T8678	9407-9408	NN	denotes	n
T8679	9408-9409	-RRB-	denotes	)
T8680	9410-9419	VBG	denotes	appearing
T8681	9420-9428	JJ	denotes	pyknotic
T8682	9429-9432	CC	denotes	and
T8683	9433-9441	JJ	denotes	abnormal
T8684	9442-9452	NN	denotes	deposition
T8685	9453-9455	IN	denotes	of
T8686	9456-9462	NN	denotes	matrix
T8688	9463-9464	-LRB-	denotes	(
T8689	9464-9466	NN	denotes	mx
T8690	9466-9467	-RRB-	denotes	)
T8687	9468-9476	NN	denotes	material
T8691	9477-9479	IN	denotes	of
T8692	9480-9487	JJ	denotes	unknown
T8693	9488-9496	NN	denotes	identity
T8694	9497-9501	VBD	denotes	were
T8670	9502-9506	VBN	denotes	seen
T8695	9506-9508	,	denotes	,
T8696	9508-9513	IN	denotes	along
T8697	9514-9518	IN	denotes	with
T8698	9519-9524	JJ	denotes	large
T8699	9525-9532	NNS	denotes	amounts
T8700	9533-9535	IN	denotes	of
T8701	9536-9546	JJ	denotes	membranous
T8702	9547-9555	NNS	denotes	vesicles
T8703	9556-9557	-LRB-	denotes	(
T8704	9557-9562	NN	denotes	arrow
T8705	9562-9563	-RRB-	denotes	)
T8706	9564-9569	WDT	denotes	which
T8707	9570-9576	VBD	denotes	filled
T8708	9577-9580	DT	denotes	the
T8710	9581-9594	NN	denotes	photoreceptor
T8709	9595-9600	NN	denotes	space
T8711	9601-9604	CC	denotes	and
T8712	9605-9613	VBD	denotes	appeared
T8713	9614-9616	TO	denotes	to
T8715	9617-9619	VB	denotes	be
T8714	9620-9628	VBN	denotes	released
T8716	9629-9633	IN	denotes	from
T8717	9634-9639	JJ	denotes	inner
T8718	9640-9648	NNS	denotes	segments
T8719	9648-9649	.	denotes	.
T8720	9649-9669	sentence	denotes	Scale bar = 3.7 μm.
T8721	9650-9655	NN	denotes	Scale
T8722	9656-9659	NN	denotes	bar
T8724	9660-9661	SYM	denotes	=
T8725	9662-9665	CD	denotes	3.7
T8723	9666-9668	NN	denotes	μm
T8726	9668-9669	.	denotes	.
T8727	9669-9819	sentence	denotes	(B) Nonmotile connecting cilium in cross section, from a Crx-/- photoreceptor, demonstrating characteristic 9+0 radial array of microtubule doublets.
T8728	9670-9671	-LRB-	denotes	(
T8729	9671-9672	LS	denotes	B
T8731	9672-9673	-RRB-	denotes	)
T8732	9674-9683	JJ	denotes	Nonmotile
T8733	9684-9694	VBG	denotes	connecting
T8730	9695-9701	NN	denotes	cilium
T8734	9702-9704	IN	denotes	in
T8735	9705-9710	NN	denotes	cross
T8736	9711-9718	NN	denotes	section
T8737	9718-9720	,	denotes	,
T8738	9720-9724	IN	denotes	from
T8739	9725-9726	DT	denotes	a
T8741	9727-9730	NN	denotes	Crx
T8742	9730-9731	SYM	denotes	-
T8743	9731-9732	HYPH	denotes	/
T8744	9732-9733	SYM	denotes	-
T8740	9734-9747	NN	denotes	photoreceptor
T8745	9747-9749	,	denotes	,
T8746	9749-9762	VBG	denotes	demonstrating
T8747	9763-9777	JJ	denotes	characteristic
T8749	9778-9779	CD	denotes	9
T8751	9779-9780	SYM	denotes	+
T8750	9780-9781	CD	denotes	0
T8752	9782-9788	JJ	denotes	radial
T8748	9789-9794	NN	denotes	array
T8753	9795-9797	IN	denotes	of
T8754	9798-9809	NN	denotes	microtubule
T8755	9810-9818	NNS	denotes	doublets
T8756	9818-9819	.	denotes	.
T8757	9819-9838	sentence	denotes	Scale bar = 88 nm.
T8758	9820-9825	NN	denotes	Scale
T8759	9826-9829	NN	denotes	bar
T8761	9830-9831	SYM	denotes	=
T8762	9832-9834	CD	denotes	88
T8760	9835-9837	NN	denotes	nm
T8763	9837-9838	.	denotes	.
T8764	9838-9984	sentence	denotes	(C) Scanning electron micrograph (SEM) of membranous vesicles (arrow shows one example) shed from inner segments of Crx-/- photoreceptors at P10.
T8765	9839-9840	-LRB-	denotes	(
T8766	9840-9841	LS	denotes	C
T8768	9841-9842	-RRB-	denotes	)
T8769	9843-9851	VBG	denotes	Scanning
T8770	9852-9860	NN	denotes	electron
T8767	9861-9871	NN	denotes	micrograph
T8771	9872-9873	-LRB-	denotes	(
T8772	9873-9876	NN	denotes	SEM
T8773	9876-9877	-RRB-	denotes	)
T8774	9878-9880	IN	denotes	of
T8775	9881-9891	JJ	denotes	membranous
T8776	9892-9900	NNS	denotes	vesicles
T8777	9901-9902	-LRB-	denotes	(
T8779	9902-9907	NN	denotes	arrow
T8778	9908-9913	VBZ	denotes	shows
T8780	9914-9917	CD	denotes	one
T8781	9918-9925	NN	denotes	example
T8782	9925-9926	-RRB-	denotes	)
T8783	9927-9931	VBN	denotes	shed
T8784	9932-9936	IN	denotes	from
T8785	9937-9942	JJ	denotes	inner
T8786	9943-9951	NNS	denotes	segments
T8787	9952-9954	IN	denotes	of
T8788	9955-9958	NN	denotes	Crx
T8790	9958-9959	SYM	denotes	-
T8791	9959-9960	HYPH	denotes	/
T8792	9960-9961	SYM	denotes	-
T8789	9962-9976	NNS	denotes	photoreceptors
T8793	9977-9979	IN	denotes	at
T8794	9980-9983	NN	denotes	P10
T8795	9983-9984	.	denotes	.
T8796	9984-10080	sentence	denotes	Figure shows inner segments viewed from the scleral side with the pigmented epithelium removed.
T8797	9985-9991	NN	denotes	Figure
T8798	9992-9997	VBZ	denotes	shows
T8799	9998-10003	JJ	denotes	inner
T8800	10004-10012	NNS	denotes	segments
T8801	10013-10019	VBN	denotes	viewed
T8802	10020-10024	IN	denotes	from
T8803	10025-10028	DT	denotes	the
T8805	10029-10036	JJ	denotes	scleral
T8804	10037-10041	NN	denotes	side
T8806	10042-10046	IN	denotes	with
T8808	10047-10050	DT	denotes	the
T8810	10051-10060	VBN	denotes	pigmented
T8809	10061-10071	NN	denotes	epithelium
T8807	10072-10079	VBN	denotes	removed
T8811	10079-10080	.	denotes	.
T8812	10080-10098	sentence	denotes	Scale bar = 1 μm.
T8813	10081-10086	NN	denotes	Scale
T8814	10087-10090	NN	denotes	bar
T8816	10091-10092	SYM	denotes	=
T8817	10093-10094	CD	denotes	1
T8815	10095-10097	NN	denotes	μm
T8818	10097-10098	.	denotes	.
T2783	10099-10101	IN	denotes	In
T2782	10099-10121	sentence	denotes	In addition to the com
T2784	10102-10103	DT	denotes	a
T2785	10103-10105	VBN	denotes	dd
T2786	10105-10106	VBG	denotes	i
T2787	10106-10108	JJ	denotes	ti
T2788	10108-10109	JJ	denotes	o
T2789	10109-10110	NN	denotes	n
T2790	10111-10112	NN	denotes	t
T2791	10112-10113	IN	denotes	o
T2792	10114-10115	NN	denotes	t
T2793	10115-10116	IN	denotes	h
T2794	10116-10117	JJ	denotes	e
T2795	10118-10119	NNS	denotes	c
T2796	10119-10120	NN	denotes	o
T2797	10120-10121	IN	denotes	m
T2799	10121-10122	NN	denotes	p
T2798	10121-10125	sentence	denotes	plet
T2800	10122-10123	JJ	denotes	l
T2801	10123-10124	NN	denotes	e
T2802	10124-10125	NNS	denotes	t
T2804	10125-10126	NN	denotes	e
T2803	10125-10128	sentence	denotes	e a
T2805	10127-10128	NN	denotes	a
T2807	10128-10130	JJ	denotes	bs
T2806	10128-10135	sentence	denotes	bsence
T2808	10130-10131	NNS	denotes	e
T2809	10131-10132	CD	denotes	n
T2810	10132-10134	NNS	denotes	ce
T2812	10135-10136	VBZ	denotes	o
T2811	10135-10139	sentence	denotes	of o
T2813	10136-10137	IN	denotes	f
T2814	10138-10139	VBN	denotes	o
T2817	10139-10143	JJ	denotes	uter
T2815	10139-10238	sentence	denotes	uter segments, Crx-/- retinas exhibited three other notable pathologies in the outer segment layer.
T2818	10144-10152	NNS	denotes	segments
T2819	10152-10154	,	denotes	,
T2820	10154-10157	NN	denotes	Crx
T2822	10157-10158	SYM	denotes	-
T2823	10158-10159	HYPH	denotes	/
T2824	10159-10160	SYM	denotes	-
T2821	10161-10168	NNS	denotes	retinas
T2816	10169-10178	VBD	denotes	exhibited
T2825	10179-10184	CD	denotes	three
T2827	10185-10190	JJ	denotes	other
T2828	10191-10198	JJ	denotes	notable
T2826	10199-10210	NNS	denotes	pathologies
T2829	10211-10213	IN	denotes	in
T2830	10214-10217	DT	denotes	the
T2832	10218-10223	JJ	denotes	outer
T2833	10224-10231	NN	denotes	segment
T2831	10232-10237	NN	denotes	layer
T2834	10237-10238	.	denotes	.
T2835	10238-10325	sentence	denotes	First, an abnormal deposition of matrix of unknown identity was noted (Figure 3A, mx).
T2836	10239-10244	RB	denotes	First
T2838	10244-10246	,	denotes	,
T2839	10246-10248	DT	denotes	an
T2841	10249-10257	JJ	denotes	abnormal
T2840	10258-10268	NN	denotes	deposition
T2842	10269-10271	IN	denotes	of
T2843	10272-10278	NN	denotes	matrix
T2844	10279-10281	IN	denotes	of
T2845	10282-10289	JJ	denotes	unknown
T2846	10290-10298	NN	denotes	identity
T2847	10299-10302	VBD	denotes	was
T2837	10303-10308	VBN	denotes	noted
T2848	10309-10310	-LRB-	denotes	(
T2850	10310-10316	NN	denotes	Figure
T2851	10317-10319	NN	denotes	3A
T2852	10319-10321	,	denotes	,
T2849	10321-10323	NN	denotes	mx
T2853	10323-10324	-RRB-	denotes	)
T2854	10324-10325	.	denotes	.
T2855	10325-10413	sentence	denotes	Second, sporadically displaced nuclei were found residing in the space abutting the PE.
T2856	10326-10332	RB	denotes	Second
T2858	10332-10334	,	denotes	,
T2859	10334-10346	RB	denotes	sporadically
T2860	10347-10356	VBN	denotes	displaced
T2861	10357-10363	NNS	denotes	nuclei
T2862	10364-10368	VBD	denotes	were
T2857	10369-10374	VBN	denotes	found
T2863	10375-10383	VBG	denotes	residing
T2864	10384-10386	IN	denotes	in
T2865	10387-10390	DT	denotes	the
T2866	10391-10396	NN	denotes	space
T2867	10397-10405	VBG	denotes	abutting
T2868	10406-10409	DT	denotes	the
T2869	10410-10412	NN	denotes	PE
T2870	10412-10413	.	denotes	.
T2871	10413-10643	sentence	denotes	Occasionally, these nuclei appeared pyknotic (Figure 3A, n); but, more frequently exhibited the heterochromatin pattern typical of photoreceptors (data not shown), strongly suggesting that they belonged to ectopic photoreceptors.
T2872	10414-10426	RB	denotes	Occasionally
T2874	10426-10428	,	denotes	,
T2875	10428-10433	DT	denotes	these
T2876	10434-10440	NNS	denotes	nuclei
T2873	10441-10449	VBD	denotes	appeared
T2877	10450-10458	JJ	denotes	pyknotic
T2878	10459-10460	-LRB-	denotes	(
T2880	10460-10466	NN	denotes	Figure
T2881	10467-10469	NN	denotes	3A
T2882	10469-10471	,	denotes	,
T2879	10471-10472	NN	denotes	n
T2883	10472-10473	-RRB-	denotes	)
T2884	10473-10474	:	denotes	;
T2885	10475-10478	CC	denotes	but
T2886	10478-10480	,	denotes	,
T2887	10480-10484	RBR	denotes	more
T2888	10485-10495	RB	denotes	frequently
T2889	10496-10505	VBD	denotes	exhibited
T2890	10506-10509	DT	denotes	the
T2892	10510-10525	NN	denotes	heterochromatin
T2891	10526-10533	NN	denotes	pattern
T2893	10534-10541	JJ	denotes	typical
T2894	10542-10544	IN	denotes	of
T2895	10545-10559	NNS	denotes	photoreceptors
T2896	10560-10561	-LRB-	denotes	(
T2898	10561-10565	NNS	denotes	data
T2899	10566-10569	RB	denotes	not
T2897	10570-10575	VBN	denotes	shown
T2900	10575-10576	-RRB-	denotes	)
T2901	10576-10578	,	denotes	,
T2902	10578-10586	RB	denotes	strongly
T2903	10587-10597	VBG	denotes	suggesting
T2904	10598-10602	IN	denotes	that
T2906	10603-10607	PRP	denotes	they
T2905	10608-10616	VBD	denotes	belonged
T2907	10617-10619	IN	denotes	to
T2908	10620-10627	JJ	denotes	ectopic
T2909	10628-10642	NNS	denotes	photoreceptors
T2910	10642-10643	.	denotes	.
T2911	10643-10780	sentence	denotes	The third pathological entity noted in the outer segment layer were numerous small vesicles (Figure 3A arrow) 100 to 200 nm in diameter.
T2912	10644-10647	DT	denotes	The
T2914	10648-10653	JJ	denotes	third
T2915	10654-10666	JJ	denotes	pathological
T2913	10667-10673	NN	denotes	entity
T2917	10674-10679	VBN	denotes	noted
T2918	10680-10682	IN	denotes	in
T2919	10683-10686	DT	denotes	the
T2921	10687-10692	JJ	denotes	outer
T2922	10693-10700	NN	denotes	segment
T2920	10701-10706	NN	denotes	layer
T2916	10707-10711	VBD	denotes	were
T2923	10712-10720	JJ	denotes	numerous
T2925	10721-10726	JJ	denotes	small
T2924	10727-10735	NNS	denotes	vesicles
T2926	10736-10737	-LRB-	denotes	(
T2928	10737-10743	NN	denotes	Figure
T2929	10744-10746	NN	denotes	3A
T2927	10747-10752	NN	denotes	arrow
T2930	10752-10753	-RRB-	denotes	)
T2931	10754-10757	CD	denotes	100
T2933	10758-10760	IN	denotes	to
T2932	10761-10764	CD	denotes	200
T2934	10765-10767	NN	denotes	nm
T2935	10768-10770	IN	denotes	in
T2936	10771-10779	NN	denotes	diameter
T2937	10779-10780	.	denotes	.
T2938	10780-10954	sentence	denotes	They appeared to be emerging from the inner segments, as scanning electron microscopic images showed spherical structures budding from the inner segments (Figure 3C, arrow).
T2939	10781-10785	PRP	denotes	They
T2940	10786-10794	VBD	denotes	appeared
T2941	10795-10797	TO	denotes	to
T2943	10798-10800	VB	denotes	be
T2942	10801-10809	VBG	denotes	emerging
T2944	10810-10814	IN	denotes	from
T2945	10815-10818	DT	denotes	the
T2947	10819-10824	JJ	denotes	inner
T2946	10825-10833	NNS	denotes	segments
T2948	10833-10835	,	denotes	,
T2949	10835-10837	IN	denotes	as
T2951	10838-10846	VBG	denotes	scanning
T2952	10847-10855	NN	denotes	electron
T2953	10856-10867	JJ	denotes	microscopic
T2954	10868-10874	NNS	denotes	images
T2950	10875-10881	VBD	denotes	showed
T2955	10882-10891	JJ	denotes	spherical
T2956	10892-10902	NNS	denotes	structures
T2957	10903-10910	VBG	denotes	budding
T2958	10911-10915	IN	denotes	from
T2959	10916-10919	DT	denotes	the
T2961	10920-10925	JJ	denotes	inner
T2960	10926-10934	NNS	denotes	segments
T2962	10935-10936	-LRB-	denotes	(
T2964	10936-10942	NN	denotes	Figure
T2965	10943-10945	NN	denotes	3C
T2966	10945-10947	,	denotes	,
T2963	10947-10952	NN	denotes	arrow
T2967	10952-10953	-RRB-	denotes	)
T2968	10953-10954	.	denotes	.
T2969	10954-11140	sentence	denotes	In order to characterize further the morphogenesis of Crx-/- photoreceptors, the developing outer segment layer was viewed by scanning electron microscopy at P7, P14 and P21 (Figure 4).
T2970	10955-10957	IN	denotes	In
T2972	10958-10963	NN	denotes	order
T2973	10964-10966	TO	denotes	to
T2974	10967-10979	VB	denotes	characterize
T2975	10980-10987	RB	denotes	further
T2976	10988-10991	DT	denotes	the
T2977	10992-11005	NN	denotes	morphogenesis
T2978	11006-11008	IN	denotes	of
T2979	11009-11012	NN	denotes	Crx
T2981	11012-11013	SYM	denotes	-
T2982	11013-11014	HYPH	denotes	/
T2983	11014-11015	SYM	denotes	-
T2980	11016-11030	NNS	denotes	photoreceptors
T2984	11030-11032	,	denotes	,
T2985	11032-11035	DT	denotes	the
T2987	11036-11046	VBG	denotes	developing
T2988	11047-11052	JJ	denotes	outer
T2989	11053-11060	NN	denotes	segment
T2986	11061-11066	NN	denotes	layer
T2990	11067-11070	VBD	denotes	was
T2971	11071-11077	VBN	denotes	viewed
T2991	11078-11080	IN	denotes	by
T2992	11081-11089	VBG	denotes	scanning
T2994	11090-11098	NN	denotes	electron
T2993	11099-11109	NN	denotes	microscopy
T2995	11110-11112	IN	denotes	at
T2996	11113-11115	NN	denotes	P7
T2997	11115-11117	,	denotes	,
T2998	11117-11120	NN	denotes	P14
T2999	11121-11124	CC	denotes	and
T3000	11125-11128	NN	denotes	P21
T3001	11129-11130	-LRB-	denotes	(
T3002	11130-11136	NN	denotes	Figure
T3003	11137-11138	CD	denotes	4
T3004	11138-11139	-RRB-	denotes	)
T3005	11139-11140	.	denotes	.
T3006	11140-11276	sentence	denotes	In Crx+/+ retinas, photoreceptor inner segments, connecting cilia, and the first rudimentary outer segment structures were noted at P7.
T3007	11141-11143	IN	denotes	In
T3009	11144-11147	NN	denotes	Crx
T3011	11147-11148	SYM	denotes	+
T3012	11148-11149	HYPH	denotes	/
T3013	11149-11150	SYM	denotes	+
T3010	11151-11158	NNS	denotes	retinas
T3014	11158-11160	,	denotes	,
T3015	11160-11173	NN	denotes	photoreceptor
T3017	11174-11179	JJ	denotes	inner
T3016	11180-11188	NNS	denotes	segments
T3018	11188-11190	,	denotes	,
T3019	11190-11200	VBG	denotes	connecting
T3020	11201-11206	NNS	denotes	cilia
T3021	11206-11208	,	denotes	,
T3022	11208-11211	CC	denotes	and
T3023	11212-11215	DT	denotes	the
T3025	11216-11221	JJ	denotes	first
T3026	11222-11233	JJ	denotes	rudimentary
T3027	11234-11239	JJ	denotes	outer
T3028	11240-11247	NN	denotes	segment
T3024	11248-11258	NNS	denotes	structures
T3029	11259-11263	VBD	denotes	were
T3008	11264-11269	VBN	denotes	noted
T3030	11270-11272	IN	denotes	at
T3031	11273-11275	NN	denotes	P7
T3032	11275-11276	.	denotes	.
T3033	11276-11409	sentence	denotes	In the Crx-/- retina, only an occassional connecting cilium was noted emerging from inner segments at this stage (Figure 4A and 4B).
T3034	11277-11279	IN	denotes	In
T3036	11280-11283	DT	denotes	the
T3038	11284-11287	NN	denotes	Crx
T3039	11287-11288	SYM	denotes	-
T3040	11288-11289	HYPH	denotes	/
T3041	11289-11290	SYM	denotes	-
T3037	11291-11297	NN	denotes	retina
T3042	11297-11299	,	denotes	,
T3043	11299-11303	RB	denotes	only
T3045	11304-11306	DT	denotes	an
T3046	11307-11318	JJ	denotes	occassional
T3047	11319-11329	VBG	denotes	connecting
T3044	11330-11336	NN	denotes	cilium
T3048	11337-11340	VBD	denotes	was
T3049	11341-11346	VBN	denotes	noted
T3035	11347-11355	VBG	denotes	emerging
T3050	11356-11360	IN	denotes	from
T3051	11361-11366	JJ	denotes	inner
T3052	11367-11375	NNS	denotes	segments
T3053	11376-11378	IN	denotes	at
T3054	11379-11383	DT	denotes	this
T3055	11384-11389	NN	denotes	stage
T3056	11390-11391	-LRB-	denotes	(
T3058	11391-11397	NN	denotes	Figure
T3057	11398-11400	NN	denotes	4A
T3059	11401-11404	CC	denotes	and
T3060	11405-11407	NN	denotes	4B
T3061	11407-11408	-RRB-	denotes	)
T3062	11408-11409	.	denotes	.
T3063	11409-11505	sentence	denotes	This observation was confirmed by comparison with transmission electron micrographs (Figure 5).
T3064	11410-11414	DT	denotes	This
T3065	11415-11426	NN	denotes	observation
T3067	11427-11430	VBD	denotes	was
T3066	11431-11440	VBN	denotes	confirmed
T3068	11441-11443	IN	denotes	by
T3069	11444-11454	NN	denotes	comparison
T3070	11455-11459	IN	denotes	with
T3071	11460-11472	NN	denotes	transmission
T3073	11473-11481	NN	denotes	electron
T3072	11482-11493	NNS	denotes	micrographs
T3074	11494-11495	-LRB-	denotes	(
T3075	11495-11501	NN	denotes	Figure
T3076	11502-11503	CD	denotes	5
T3077	11503-11504	-RRB-	denotes	)
T3078	11504-11505	.	denotes	.
T3079	11505-11600	sentence	denotes	These differences are the earliest noted differences between Crx+/+ and Crx-/- photoreceptors.
T3080	11506-11511	DT	denotes	These
T3081	11512-11523	NNS	denotes	differences
T3082	11524-11527	VBP	denotes	are
T3083	11528-11531	DT	denotes	the
T3085	11532-11540	JJS	denotes	earliest
T3086	11541-11546	VBN	denotes	noted
T3084	11547-11558	NNS	denotes	differences
T3087	11559-11566	IN	denotes	between
T3088	11567-11570	NN	denotes	Crx
T3090	11570-11571	SYM	denotes	+
T3091	11571-11572	HYPH	denotes	/
T3092	11572-11573	SYM	denotes	+
T3093	11574-11577	CC	denotes	and
T3094	11578-11581	NN	denotes	Crx
T3095	11581-11582	SYM	denotes	-
T3096	11582-11583	HYPH	denotes	/
T3097	11583-11584	SYM	denotes	-
T3089	11585-11599	NNS	denotes	photoreceptors
T3098	11599-11600	.	denotes	.
T3099	11600-11753	sentence	denotes	At P14, elongating outer segments were noted on Crx+/+ photoreceptors, occasionally demonstrating a paddle-like structure at their apex (Figure 4C, os).
T3100	11601-11603	IN	denotes	At
T3102	11604-11607	NN	denotes	P14
T3103	11607-11609	,	denotes	,
T3104	11609-11619	VBG	denotes	elongating
T3106	11620-11625	JJ	denotes	outer
T3105	11626-11634	NNS	denotes	segments
T3107	11635-11639	VBD	denotes	were
T3101	11640-11645	VBN	denotes	noted
T3108	11646-11648	IN	denotes	on
T3109	11649-11652	NN	denotes	Crx
T3111	11652-11653	SYM	denotes	+
T3112	11653-11654	HYPH	denotes	/
T3113	11654-11655	SYM	denotes	+
T3110	11656-11670	NNS	denotes	photoreceptors
T3114	11670-11672	,	denotes	,
T3115	11672-11684	RB	denotes	occasionally
T3116	11685-11698	VBG	denotes	demonstrating
T3117	11699-11700	DT	denotes	a
T3119	11701-11707	NN	denotes	paddle
T3121	11707-11708	HYPH	denotes	-
T3120	11708-11712	JJ	denotes	like
T3118	11713-11722	NN	denotes	structure
T3122	11723-11725	IN	denotes	at
T3123	11726-11731	PRP$	denotes	their
T3124	11732-11736	NN	denotes	apex
T3125	11737-11738	-LRB-	denotes	(
T3127	11738-11744	NN	denotes	Figure
T3128	11745-11747	NN	denotes	4C
T3129	11747-11749	,	denotes	,
T3126	11749-11751	NN	denotes	os
T3130	11751-11752	-RRB-	denotes	)
T3131	11752-11753	.	denotes	.
T3132	11753-11892	sentence	denotes	In Crx-/- retinae, the vast majority of photoreceptors at this stage demonstrated connecting cilia without outer segments (Figure 4D, cc).
T3133	11754-11756	IN	denotes	In
T3135	11757-11760	NN	denotes	Crx
T3137	11760-11761	SYM	denotes	-
T3138	11761-11762	HYPH	denotes	/
T3139	11762-11763	SYM	denotes	-
T3136	11764-11771	NNS	denotes	retinae
T3140	11771-11773	,	denotes	,
T3141	11773-11776	DT	denotes	the
T3143	11777-11781	JJ	denotes	vast
T3142	11782-11790	NN	denotes	majority
T3144	11791-11793	IN	denotes	of
T3145	11794-11808	NNS	denotes	photoreceptors
T3146	11809-11811	IN	denotes	at
T3147	11812-11816	DT	denotes	this
T3148	11817-11822	NN	denotes	stage
T3134	11823-11835	VBD	denotes	demonstrated
T3149	11836-11846	VBG	denotes	connecting
T3150	11847-11852	NNS	denotes	cilia
T3151	11853-11860	IN	denotes	without
T3152	11861-11866	JJ	denotes	outer
T3153	11867-11875	NNS	denotes	segments
T3154	11876-11877	-LRB-	denotes	(
T3156	11877-11883	NN	denotes	Figure
T3157	11884-11886	NN	denotes	4D
T3158	11886-11888	,	denotes	,
T3155	11888-11890	NN	denotes	cc
T3159	11890-11891	-RRB-	denotes	)
T3160	11891-11892	.	denotes	.
T3161	11892-12065	sentence	denotes	Sporadically, Crx-/- photoreceptors would exhibit an irregular structure extending from a connecting cilium (Figure 4D, cc*) perhaps representing a malformed outer segment.
T3162	11893-11905	RB	denotes	Sporadically
T3164	11905-11907	,	denotes	,
T3165	11907-11910	NN	denotes	Crx
T3167	11910-11911	SYM	denotes	-
T3168	11911-11912	HYPH	denotes	/
T3169	11912-11913	SYM	denotes	-
T3166	11914-11928	NNS	denotes	photoreceptors
T3170	11929-11934	MD	denotes	would
T3163	11935-11942	VB	denotes	exhibit
T3171	11943-11945	DT	denotes	an
T3173	11946-11955	JJ	denotes	irregular
T3172	11956-11965	NN	denotes	structure
T3174	11966-11975	VBG	denotes	extending
T3175	11976-11980	IN	denotes	from
T3176	11981-11982	DT	denotes	a
T3178	11983-11993	VBG	denotes	connecting
T3177	11994-12000	NN	denotes	cilium
T3179	12001-12002	-LRB-	denotes	(
T3181	12002-12008	NN	denotes	Figure
T3182	12009-12011	NN	denotes	4D
T3183	12011-12013	,	denotes	,
T3180	12013-12016	NN	denotes	cc*
T3184	12016-12017	-RRB-	denotes	)
T3185	12018-12025	RB	denotes	perhaps
T3186	12026-12038	VBG	denotes	representing
T3187	12039-12040	DT	denotes	a
T3189	12041-12050	JJ	denotes	malformed
T3190	12051-12056	JJ	denotes	outer
T3188	12057-12064	NN	denotes	segment
T3191	12064-12065	.	denotes	.
T3192	12065-12125	sentence	denotes	Such structures were also observed at P21 (Figure 4F, cc*).
T3193	12066-12070	JJ	denotes	Such
T3194	12071-12081	NNS	denotes	structures
T3196	12082-12086	VBD	denotes	were
T3197	12087-12091	RB	denotes	also
T3195	12092-12100	VBN	denotes	observed
T3198	12101-12103	IN	denotes	at
T3199	12104-12107	NN	denotes	P21
T3200	12108-12109	-LRB-	denotes	(
T3202	12109-12115	NN	denotes	Figure
T3203	12116-12118	NN	denotes	4F
T3204	12118-12120	,	denotes	,
T3201	12120-12123	NN	denotes	cc*
T3205	12123-12124	-RRB-	denotes	)
T3206	12124-12125	.	denotes	.
T3207	12125-12248	sentence	denotes	These putative, abnormal outer segments were only rarely noted in Crx+/+ at P14, and never at P21 (Figure 4C and 4E, cc*).
T3208	12126-12131	DT	denotes	These
T3210	12132-12140	JJ	denotes	putative
T3211	12140-12142	,	denotes	,
T3212	12142-12150	JJ	denotes	abnormal
T3213	12151-12156	JJ	denotes	outer
T3209	12157-12165	NNS	denotes	segments
T3215	12166-12170	VBD	denotes	were
T3216	12171-12175	RB	denotes	only
T3217	12176-12182	RB	denotes	rarely
T3214	12183-12188	VBN	denotes	noted
T3218	12189-12191	IN	denotes	in
T3219	12192-12195	NN	denotes	Crx
T3220	12195-12196	SYM	denotes	+
T3221	12196-12197	HYPH	denotes	/
T3222	12197-12198	SYM	denotes	+
T3223	12199-12201	IN	denotes	at
T3224	12202-12205	NN	denotes	P14
T3225	12205-12207	,	denotes	,
T3226	12207-12210	CC	denotes	and
T3227	12211-12216	RB	denotes	never
T3228	12217-12219	IN	denotes	at
T3229	12220-12223	NN	denotes	P21
T3230	12224-12225	-LRB-	denotes	(
T3232	12225-12231	NN	denotes	Figure
T3233	12232-12234	NN	denotes	4C
T3234	12235-12238	CC	denotes	and
T3235	12239-12241	NN	denotes	4E
T3236	12241-12243	,	denotes	,
T3231	12243-12245	NN	denotes	cc
T3237	12245-12246	SYM	denotes	*
T3238	12246-12247	-RRB-	denotes	)
T3239	12247-12248	.	denotes	.
T3240	12248-12343	sentence	denotes	Further, in Crx-/- photoreceptors, unusually long connecting cilia were noted (Figure 4F, cc).
T3241	12249-12256	RB	denotes	Further
T3243	12256-12258	,	denotes	,
T3244	12258-12260	IN	denotes	in
T3245	12261-12264	NN	denotes	Crx
T3247	12264-12265	SYM	denotes	-
T3248	12265-12266	HYPH	denotes	/
T3249	12266-12267	SYM	denotes	-
T3246	12268-12282	NNS	denotes	photoreceptors
T3250	12282-12284	,	denotes	,
T3251	12284-12293	RB	denotes	unusually
T3252	12294-12298	JJ	denotes	long
T3254	12299-12309	VBG	denotes	connecting
T3253	12310-12315	NNS	denotes	cilia
T3255	12316-12320	VBD	denotes	were
T3242	12321-12326	VBN	denotes	noted
T3256	12327-12328	-LRB-	denotes	(
T3258	12328-12334	NN	denotes	Figure
T3259	12335-12337	NN	denotes	4F
T3260	12337-12339	,	denotes	,
T3257	12339-12341	NN	denotes	cc
T3261	12341-12342	-RRB-	denotes	)
T3262	12342-12343	.	denotes	.
T3263	12343-12528	sentence	denotes	Serial examination of Crx-/- photoreceptors at P7, P10, P14, and P21 by TEM, demonstrated a distinctive lack of any structure interpretable as orderly stacks of discs or forming discs.
T3264	12344-12350	JJ	denotes	Serial
T3265	12351-12362	NN	denotes	examination
T3267	12363-12365	IN	denotes	of
T3268	12366-12369	NN	denotes	Crx
T3270	12369-12370	SYM	denotes	-
T3271	12370-12371	HYPH	denotes	/
T3272	12371-12372	SYM	denotes	-
T3269	12373-12387	NNS	denotes	photoreceptors
T3273	12388-12390	IN	denotes	at
T3274	12391-12393	NN	denotes	P7
T3275	12393-12395	,	denotes	,
T3276	12395-12398	NN	denotes	P10
T3277	12398-12400	,	denotes	,
T3278	12400-12403	NN	denotes	P14
T3279	12403-12405	,	denotes	,
T3280	12405-12408	CC	denotes	and
T3281	12409-12412	NN	denotes	P21
T3282	12413-12415	IN	denotes	by
T3283	12416-12419	NN	denotes	TEM
T3284	12419-12421	,	denotes	,
T3266	12421-12433	VBD	denotes	demonstrated
T3285	12434-12435	DT	denotes	a
T3287	12436-12447	JJ	denotes	distinctive
T3286	12448-12452	NN	denotes	lack
T3288	12453-12455	IN	denotes	of
T3289	12456-12459	DT	denotes	any
T3290	12460-12469	NN	denotes	structure
T3291	12470-12483	JJ	denotes	interpretable
T3292	12484-12486	IN	denotes	as
T3293	12487-12494	JJ	denotes	orderly
T3294	12495-12501	NNS	denotes	stacks
T3295	12502-12504	IN	denotes	of
T3296	12505-12510	NNS	denotes	discs
T3297	12511-12513	CC	denotes	or
T3298	12514-12521	VBG	denotes	forming
T3299	12522-12527	NNS	denotes	discs
T3300	12527-12528	.	denotes	.
T3301	12528-12742	sentence	denotes	These data demonstrate a complete absence of normal outer segment formation in the Crx mutant mouse, and the arrest of development of the photoreceptor appendage at the elongation stage of outer segment formation.
T3302	12529-12534	DT	denotes	These
T3303	12535-12539	NNS	denotes	data
T3304	12540-12551	VBP	denotes	demonstrate
T3305	12552-12553	DT	denotes	a
T3307	12554-12562	JJ	denotes	complete
T3306	12563-12570	NN	denotes	absence
T3308	12571-12573	IN	denotes	of
T3309	12574-12580	JJ	denotes	normal
T3311	12581-12586	JJ	denotes	outer
T3312	12587-12594	NN	denotes	segment
T3310	12595-12604	NN	denotes	formation
T3313	12605-12607	IN	denotes	in
T3314	12608-12611	DT	denotes	the
T3316	12612-12615	NN	denotes	Crx
T3317	12616-12622	NN	denotes	mutant
T3315	12623-12628	NN	denotes	mouse
T3318	12628-12630	,	denotes	,
T3319	12630-12633	CC	denotes	and
T3320	12634-12637	DT	denotes	the
T3321	12638-12644	NN	denotes	arrest
T3322	12645-12647	IN	denotes	of
T3323	12648-12659	NN	denotes	development
T3324	12660-12662	IN	denotes	of
T3325	12663-12666	DT	denotes	the
T3327	12667-12680	NN	denotes	photoreceptor
T3326	12681-12690	NN	denotes	appendage
T3328	12691-12693	IN	denotes	at
T3329	12694-12697	DT	denotes	the
T3331	12698-12708	NN	denotes	elongation
T3330	12709-12714	NN	denotes	stage
T3332	12715-12717	IN	denotes	of
T3333	12718-12723	JJ	denotes	outer
T3334	12724-12731	NN	denotes	segment
T3335	12732-12741	NN	denotes	formation
T3336	12741-12742	.	denotes	.
T3337	12742-12745	sentence	denotes	Fi
T3338	12743-12745	NN	denotes	Fi
T8923	12753-12758	NN	denotes	Outer
T8924	12759-12766	NN	denotes	segment
T8925	12767-12780	NN	denotes	morphogenesis
T8926	12781-12783	IN	denotes	in
T8927	12784-12787	NN	denotes	Crx
T8929	12787-12788	SYM	denotes	-
T8930	12788-12789	HYPH	denotes	/
T8931	12789-12790	SYM	denotes	-
T8928	12791-12805	NNS	denotes	photoreceptors
T8932	12805-12806	.	denotes	.
T8933	12806-13010	sentence	denotes	Scanning electron microscopy of developing photoreceptors viewed from the scleral side with the pigmented epithelium removed at P7, P14, and P21 for Crx+/+ (A, C, and E) and Crx-/- (B, D, F) littermates.
T8934	12807-12815	VBG	denotes	Scanning
T8936	12816-12824	NN	denotes	electron
T8935	12825-12835	NN	denotes	microscopy
T8937	12836-12838	IN	denotes	of
T8938	12839-12849	VBG	denotes	developing
T8939	12850-12864	NNS	denotes	photoreceptors
T8940	12865-12871	VBN	denotes	viewed
T8941	12872-12876	IN	denotes	from
T8942	12877-12880	DT	denotes	the
T8944	12881-12888	JJ	denotes	scleral
T8943	12889-12893	NN	denotes	side
T8945	12894-12898	IN	denotes	with
T8947	12899-12902	DT	denotes	the
T8949	12903-12912	JJ	denotes	pigmented
T8948	12913-12923	NN	denotes	epithelium
T8946	12924-12931	VBN	denotes	removed
T8950	12932-12934	IN	denotes	at
T8951	12935-12937	NN	denotes	P7
T8952	12937-12939	,	denotes	,
T8953	12939-12942	NN	denotes	P14
T8954	12942-12944	,	denotes	,
T8955	12944-12947	CC	denotes	and
T8956	12948-12951	NN	denotes	P21
T8957	12952-12955	IN	denotes	for
T8958	12956-12959	NN	denotes	Crx
T8960	12959-12960	SYM	denotes	+
T8961	12960-12961	HYPH	denotes	/
T8962	12961-12962	SYM	denotes	+
T8963	12963-12964	-LRB-	denotes	(
T8964	12964-12965	NN	denotes	A
T8965	12965-12967	,	denotes	,
T8966	12967-12968	NN	denotes	C
T8967	12968-12970	,	denotes	,
T8968	12970-12973	CC	denotes	and
T8969	12974-12975	NN	denotes	E
T8970	12975-12976	-RRB-	denotes	)
T8971	12977-12980	CC	denotes	and
T8972	12981-12984	NN	denotes	Crx
T8973	12984-12985	SYM	denotes	-
T8974	12985-12986	HYPH	denotes	/
T8975	12986-12987	SYM	denotes	-
T8976	12988-12989	-LRB-	denotes	(
T8978	12989-12990	NN	denotes	B
T8979	12990-12992	,	denotes	,
T8980	12992-12993	NN	denotes	D
T8981	12993-12995	,	denotes	,
T8977	12995-12996	NN	denotes	F
T8982	12996-12997	-RRB-	denotes	)
T8959	12998-13009	NNS	denotes	littermates
T8983	13009-13010	.	denotes	.
T8984	13010-13114	sentence	denotes	In Crx+/+ retina, numerous connecting cilia (A, cc) were evident at P7 with rudimentary outer segments.
T8985	13011-13013	IN	denotes	In
T8987	13014-13017	NN	denotes	Crx
T8989	13017-13018	SYM	denotes	+
T8990	13018-13019	HYPH	denotes	/
T8991	13019-13020	SYM	denotes	+
T8988	13021-13027	NN	denotes	retina
T8992	13027-13029	,	denotes	,
T8993	13029-13037	JJ	denotes	numerous
T8995	13038-13048	VBG	denotes	connecting
T8994	13049-13054	NNS	denotes	cilia
T8996	13055-13056	-LRB-	denotes	(
T8998	13056-13057	NN	denotes	A
T8999	13057-13059	,	denotes	,
T8997	13059-13061	NN	denotes	cc
T9000	13061-13062	-RRB-	denotes	)
T8986	13063-13067	VBD	denotes	were
T9001	13068-13075	JJ	denotes	evident
T9002	13076-13078	IN	denotes	at
T9003	13079-13081	NN	denotes	P7
T9004	13082-13086	IN	denotes	with
T9005	13087-13098	JJ	denotes	rudimentary
T9007	13099-13104	JJ	denotes	outer
T9006	13105-13113	NNS	denotes	segments
T9008	13113-13114	.	denotes	.
T9009	13114-13167	sentence	denotes	After P7, in Crx+/+ outer segment elongation occurs.
T9010	13115-13120	IN	denotes	After
T9012	13121-13123	NN	denotes	P7
T9013	13123-13125	,	denotes	,
T9014	13125-13127	IN	denotes	in
T9015	13128-13131	NN	denotes	Crx
T9016	13131-13132	SYM	denotes	+
T9017	13132-13133	HYPH	denotes	/
T9018	13133-13134	SYM	denotes	+
T9019	13135-13140	JJ	denotes	outer
T9020	13141-13148	NN	denotes	segment
T9021	13149-13159	NN	denotes	elongation
T9011	13160-13166	VBZ	denotes	occurs
T9022	13166-13167	.	denotes	.
T9023	13167-13259	sentence	denotes	Initially, outer segments have a paddle-like structure (C, os) which is later shed (E, os).
T9024	13168-13177	RB	denotes	Initially
T9026	13177-13179	,	denotes	,
T9027	13179-13184	JJ	denotes	outer
T9028	13185-13193	NNS	denotes	segments
T9025	13194-13198	VBP	denotes	have
T9029	13199-13200	DT	denotes	a
T9031	13201-13207	NN	denotes	paddle
T9033	13207-13208	HYPH	denotes	-
T9032	13208-13212	JJ	denotes	like
T9030	13213-13222	NN	denotes	structure
T9034	13223-13224	-LRB-	denotes	(
T9036	13224-13225	NN	denotes	C
T9037	13225-13227	,	denotes	,
T9035	13227-13229	NN	denotes	os
T9038	13229-13230	-RRB-	denotes	)
T9039	13231-13236	WDT	denotes	which
T9041	13237-13239	VBZ	denotes	is
T9042	13240-13245	RB	denotes	later
T9040	13246-13250	VBN	denotes	shed
T9043	13251-13252	-LRB-	denotes	(
T9045	13252-13253	NN	denotes	E
T9046	13253-13255	,	denotes	,
T9044	13255-13257	NN	denotes	os
T9047	13257-13258	-RRB-	denotes	)
T9048	13258-13259	.	denotes	.
T9049	13259-13335	sentence	denotes	In Crx-/- photoreceptors, few connecting cilia were observed at P7 (B, cc).
T9050	13260-13262	IN	denotes	In
T9052	13263-13266	NN	denotes	Crx
T9054	13266-13267	SYM	denotes	-
T9055	13267-13268	HYPH	denotes	/
T9056	13268-13269	SYM	denotes	-
T9053	13270-13284	NNS	denotes	photoreceptors
T9057	13284-13286	,	denotes	,
T9058	13286-13289	JJ	denotes	few
T9060	13290-13300	VBG	denotes	connecting
T9059	13301-13306	NNS	denotes	cilia
T9061	13307-13311	VBD	denotes	were
T9051	13312-13320	VBN	denotes	observed
T9062	13321-13323	IN	denotes	at
T9063	13324-13326	NN	denotes	P7
T9064	13327-13328	-LRB-	denotes	(
T9066	13328-13329	NN	denotes	B
T9067	13329-13331	,	denotes	,
T9065	13331-13333	NN	denotes	cc
T9068	13333-13334	-RRB-	denotes	)
T9069	13334-13335	.	denotes	.
T9070	13335-13485	sentence	denotes	After P7, connecting cilia were more numerous and occasionally a malformed outer segment was noted extending from a connecting cilium (D and F, cc*).
T9071	13336-13341	IN	denotes	After
T9073	13342-13344	NN	denotes	P7
T9074	13344-13346	,	denotes	,
T9075	13346-13356	VBG	denotes	connecting
T9076	13357-13362	NNS	denotes	cilia
T9072	13363-13367	VBD	denotes	were
T9077	13368-13372	RBR	denotes	more
T9078	13373-13381	JJ	denotes	numerous
T9079	13382-13385	CC	denotes	and
T9080	13386-13398	RB	denotes	occasionally
T9082	13399-13400	DT	denotes	a
T9084	13401-13410	JJ	denotes	malformed
T9085	13411-13416	JJ	denotes	outer
T9083	13417-13424	NN	denotes	segment
T9086	13425-13428	VBD	denotes	was
T9081	13429-13434	VBN	denotes	noted
T9087	13435-13444	VBG	denotes	extending
T9088	13445-13449	IN	denotes	from
T9089	13450-13451	DT	denotes	a
T9091	13452-13462	VBG	denotes	connecting
T9090	13463-13469	NN	denotes	cilium
T9092	13470-13471	-LRB-	denotes	(
T9094	13471-13472	NN	denotes	D
T9095	13473-13476	CC	denotes	and
T9096	13477-13478	NN	denotes	F
T9097	13478-13480	,	denotes	,
T9093	13480-13483	NN	denotes	cc*
T9098	13483-13484	-RRB-	denotes	)
T9099	13484-13485	.	denotes	.
T9100	13485-13548	sentence	denotes	These were rarely observed in Crx+/+ and only at P14 (C, cc*).
T9101	13486-13491	DT	denotes	These
T9103	13492-13496	VBD	denotes	were
T9104	13497-13503	RB	denotes	rarely
T9102	13504-13512	VBN	denotes	observed
T9105	13513-13515	IN	denotes	in
T9106	13516-13519	NN	denotes	Crx
T9107	13519-13520	SYM	denotes	+
T9108	13520-13521	HYPH	denotes	/
T9109	13521-13522	SYM	denotes	+
T9110	13523-13526	CC	denotes	and
T9111	13527-13531	RB	denotes	only
T9112	13532-13534	IN	denotes	at
T9113	13535-13538	NN	denotes	P14
T9114	13539-13540	-LRB-	denotes	(
T9116	13540-13541	NN	denotes	C
T9117	13541-13543	,	denotes	,
T9115	13543-13546	NN	denotes	cc*
T9118	13546-13547	-RRB-	denotes	)
T9119	13547-13548	.	denotes	.
T9120	13548-13618	sentence	denotes	At P21, abnormally long connecting cilia are noted in Crx-/- (F, cc).
T9121	13549-13551	IN	denotes	At
T9123	13552-13555	NN	denotes	P21
T9124	13555-13557	,	denotes	,
T9125	13557-13567	RB	denotes	abnormally
T9126	13568-13572	JJ	denotes	long
T9128	13573-13583	VBG	denotes	connecting
T9127	13584-13589	NNS	denotes	cilia
T9129	13590-13593	VBP	denotes	are
T9122	13594-13599	VBN	denotes	noted
T9130	13600-13602	IN	denotes	in
T9131	13603-13606	NN	denotes	Crx
T9132	13606-13607	SYM	denotes	-
T9133	13607-13608	HYPH	denotes	/
T9134	13608-13609	SYM	denotes	-
T9135	13610-13611	-LRB-	denotes	(
T9137	13611-13612	NN	denotes	F
T9138	13612-13614	,	denotes	,
T9136	13614-13616	NN	denotes	cc
T9139	13616-13617	-RRB-	denotes	)
T9140	13617-13618	.	denotes	.
T9141	13618-13637	sentence	denotes	Scale bars = 10 μm
T9142	13619-13624	NN	denotes	Scale
T9143	13625-13629	NNS	denotes	bars
T9145	13630-13631	SYM	denotes	=
T9146	13632-13634	CD	denotes	10
T9144	13635-13637	NN	denotes	μm
T9204	13648-13660	NN	denotes	Transmission
T9206	13661-13669	NN	denotes	electron
T9205	13670-13681	NNS	denotes	micrographs
T9207	13682-13684	IN	denotes	of
T9208	13685-13688	NN	denotes	Crx
T9210	13688-13689	SYM	denotes	-
T9211	13689-13690	HYPH	denotes	/
T9212	13690-13691	SYM	denotes	-
T9209	13692-13706	NNS	denotes	photoreceptors
T9213	13707-13709	IN	denotes	in
T9214	13710-13713	DT	denotes	the
T9216	13714-13727	NN	denotes	photoreceptor
T9215	13728-13733	NN	denotes	layer
T9217	13734-13736	IN	denotes	at
T9218	13737-13739	NN	denotes	P7
T9219	13739-13740	.	denotes	.
T9220	13740-13887	sentence	denotes	(A) Photoreceptor layer of Crx+/+ retina demonstrating nascent outer segment structures (arrow) emerging from photoreceptor connecting cilia (cc).
T9221	13741-13742	-LRB-	denotes	(
T9222	13742-13743	LS	denotes	A
T9224	13743-13744	-RRB-	denotes	)
T9225	13745-13758	NN	denotes	Photoreceptor
T9223	13759-13764	NN	denotes	layer
T9226	13765-13767	IN	denotes	of
T9227	13768-13771	NN	denotes	Crx
T9229	13771-13772	SYM	denotes	+
T9230	13772-13773	HYPH	denotes	/
T9231	13773-13774	SYM	denotes	+
T9228	13775-13781	NN	denotes	retina
T9232	13782-13795	VBG	denotes	demonstrating
T9233	13796-13803	JJ	denotes	nascent
T9235	13804-13809	JJ	denotes	outer
T9236	13810-13817	NN	denotes	segment
T9234	13818-13828	NNS	denotes	structures
T9238	13829-13830	-LRB-	denotes	(
T9239	13830-13835	NN	denotes	arrow
T9240	13835-13836	-RRB-	denotes	)
T9237	13837-13845	VBG	denotes	emerging
T9241	13846-13850	IN	denotes	from
T9242	13851-13864	NN	denotes	photoreceptor
T9244	13865-13875	VBG	denotes	connecting
T9243	13876-13881	NNS	denotes	cilia
T9245	13882-13883	-LRB-	denotes	(
T9246	13883-13885	NN	denotes	cc
T9247	13885-13886	-RRB-	denotes	)
T9248	13886-13887	.	denotes	.
T9249	13887-14027	sentence	denotes	(B) Crx-/- photoreceptors exhibited connecting cilia (cc) at this early stage, however, nascent outer segment structures were not observed.
T9250	13888-13889	-LRB-	denotes	(
T9251	13889-13890	LS	denotes	B
T9253	13890-13891	-RRB-	denotes	)
T9254	13892-13895	NN	denotes	Crx
T9256	13895-13896	SYM	denotes	-
T9257	13896-13897	HYPH	denotes	/
T9258	13897-13898	SYM	denotes	-
T9255	13899-13913	NNS	denotes	photoreceptors
T9259	13914-13923	VBD	denotes	exhibited
T9260	13924-13934	VBG	denotes	connecting
T9261	13935-13940	NNS	denotes	cilia
T9262	13941-13942	-LRB-	denotes	(
T9263	13942-13944	NN	denotes	cc
T9264	13944-13945	-RRB-	denotes	)
T9265	13946-13948	IN	denotes	at
T9266	13949-13953	DT	denotes	this
T9268	13954-13959	JJ	denotes	early
T9267	13960-13965	NN	denotes	stage
T9269	13965-13967	,	denotes	,
T9270	13967-13974	RB	denotes	however
T9271	13974-13976	,	denotes	,
T9272	13976-13983	JJ	denotes	nascent
T9274	13984-13989	JJ	denotes	outer
T9275	13990-13997	NN	denotes	segment
T9273	13998-14008	NNS	denotes	structures
T9276	14009-14013	VBD	denotes	were
T9277	14014-14017	RB	denotes	not
T9252	14018-14026	VBN	denotes	observed
T9278	14026-14027	.	denotes	.
T9279	14027-14045	sentence	denotes	Scale Bar = 1 μm.
T9280	14028-14033	NN	denotes	Scale
T9281	14034-14037	NN	denotes	Bar
T9283	14038-14039	SYM	denotes	=
T9284	14040-14041	CD	denotes	1
T9282	14042-14044	NN	denotes	μm
T9285	14044-14045	.	denotes	.
T3339	14048-14049	sentence	denotes	n
T3340	14048-14049	NN	denotes	n
T3342	14049-14050	VBG	denotes	a
T3341	14049-14052	sentence	denotes	all
T3343	14050-14051	NN	denotes	l
T3344	14051-14052	VBG	denotes	l
T3345	14052-14053	sentence	denotes	y
T3346	14052-14053	JJ	denotes	y
T3348	14053-14055	,	denotes	,
T3347	14053-14056	sentence	denotes	, t
T3349	14055-14056	JJ	denotes	t
T3351	14056-14058	VBP	denotes	he
T3350	14056-14059	sentence	denotes	he
T3352	14059-14062	sentence	denotes	mor
T3353	14059-14062	RBR	denotes	mor
T3355	14062-14064	NNS	denotes	ph
T3354	14062-14066	sentence	denotes	phol
T3356	14064-14065	IN	denotes	o
T3357	14065-14066	NN	denotes	l
T3359	14066-14067	NN	denotes	o
T3358	14066-14068	sentence	denotes	og
T3360	14067-14068	VBG	denotes	g
T3362	14068-14069	JJ	denotes	y
T3361	14068-14071	sentence	denotes	y o
T3363	14070-14071	RB	denotes	o
T3366	14071-14072	IN	denotes	f
T3364	14071-14171	sentence	denotes	f the malformed Crx-/- photoreceptors was compared to rhodopsin-/- and peripherin-/- photoreceptors.
T3367	14073-14076	DT	denotes	the
T3369	14077-14086	JJ	denotes	malformed
T3370	14087-14090	NN	denotes	Crx
T3371	14090-14091	SYM	denotes	-
T3372	14091-14092	HYPH	denotes	/
T3373	14092-14093	SYM	denotes	-
T3368	14094-14108	NNS	denotes	photoreceptors
T3374	14109-14112	VBD	denotes	was
T3365	14113-14121	VBN	denotes	compared
T3375	14122-14124	IN	denotes	to
T3376	14125-14134	NN	denotes	rhodopsin
T3378	14134-14135	SYM	denotes	-
T3379	14135-14136	HYPH	denotes	/
T3380	14136-14137	SYM	denotes	-
T3381	14138-14141	CC	denotes	and
T3382	14142-14152	NN	denotes	peripherin
T3383	14152-14153	SYM	denotes	-
T3384	14153-14154	HYPH	denotes	/
T3385	14154-14155	SYM	denotes	-
T3377	14156-14170	NNS	denotes	photoreceptors
T3386	14170-14171	.	denotes	.
T3387	14171-14315	sentence	denotes	Rhodopsin and peripherin are two photoreceptor-specific genes whose expression is significantly downregulated in the Crx-/- retinae [10,34,35].
T3388	14172-14181	NN	denotes	Rhodopsin
T3390	14182-14185	CC	denotes	and
T3391	14186-14196	NN	denotes	peripherin
T3389	14197-14200	VBP	denotes	are
T3392	14201-14204	CD	denotes	two
T3394	14205-14218	NN	denotes	photoreceptor
T3396	14218-14219	HYPH	denotes	-
T3395	14219-14227	JJ	denotes	specific
T3393	14228-14233	NNS	denotes	genes
T3397	14234-14239	WP$	denotes	whose
T3398	14240-14250	NN	denotes	expression
T3400	14251-14253	VBZ	denotes	is
T3401	14254-14267	RB	denotes	significantly
T3399	14268-14281	VBN	denotes	downregulated
T3402	14282-14284	IN	denotes	in
T3403	14285-14288	DT	denotes	the
T3405	14289-14292	NN	denotes	Crx
T3406	14292-14293	SYM	denotes	-
T3407	14293-14294	HYPH	denotes	/
T3408	14294-14295	SYM	denotes	-
T3404	14296-14303	NNS	denotes	retinae
T3409	14304-14305	-LRB-	denotes	[
T3411	14305-14307	CD	denotes	10
T3412	14307-14308	,	denotes	,
T3413	14308-14310	CD	denotes	34
T3414	14310-14311	,	denotes	,
T3410	14311-14313	CD	denotes	35
T3415	14313-14314	-RRB-	denotes	]
T3416	14314-14315	.	denotes	.
T3417	14315-14455	sentence	denotes	Loss of function mutations in each of these genes separately have been reported to result in a failure to elaborate outer segments [29,30].
T3418	14316-14320	NN	denotes	Loss
T3420	14321-14323	IN	denotes	of
T3421	14324-14332	NN	denotes	function
T3419	14333-14342	NNS	denotes	mutations
T3423	14343-14345	IN	denotes	in
T3424	14346-14350	DT	denotes	each
T3425	14351-14353	IN	denotes	of
T3426	14354-14359	DT	denotes	these
T3427	14360-14365	NNS	denotes	genes
T3428	14366-14376	RB	denotes	separately
T3429	14377-14381	VBP	denotes	have
T3430	14382-14386	VBN	denotes	been
T3422	14387-14395	VBN	denotes	reported
T3431	14396-14398	TO	denotes	to
T3432	14399-14405	VB	denotes	result
T3433	14406-14408	IN	denotes	in
T3434	14409-14410	DT	denotes	a
T3435	14411-14418	NN	denotes	failure
T3436	14419-14421	TO	denotes	to
T3437	14422-14431	VB	denotes	elaborate
T3438	14432-14437	JJ	denotes	outer
T3439	14438-14446	NNS	denotes	segments
T3440	14447-14448	-LRB-	denotes	[
T3442	14448-14450	CD	denotes	29
T3443	14450-14451	,	denotes	,
T3441	14451-14453	CD	denotes	30
T3444	14453-14454	-RRB-	denotes	]
T3445	14454-14455	.	denotes	.
T3446	14455-14625	sentence	denotes	Photoreceptors from these two mutant mice examined by SEM from the scleral side appeared highly similar to Crx-/- photoreceptors (compare Figure 4F to Figure 6A and 6B).
T3447	14456-14470	NNS	denotes	Photoreceptors
T3449	14471-14475	IN	denotes	from
T3450	14476-14481	DT	denotes	these
T3452	14482-14485	CD	denotes	two
T3453	14486-14492	JJ	denotes	mutant
T3451	14493-14497	NNS	denotes	mice
T3454	14498-14506	VBN	denotes	examined
T3455	14507-14509	IN	denotes	by
T3456	14510-14513	NN	denotes	SEM
T3457	14514-14518	IN	denotes	from
T3458	14519-14522	DT	denotes	the
T3460	14523-14530	JJ	denotes	scleral
T3459	14531-14535	NN	denotes	side
T3448	14536-14544	VBD	denotes	appeared
T3461	14545-14551	RB	denotes	highly
T3462	14552-14559	JJ	denotes	similar
T3463	14560-14562	IN	denotes	to
T3464	14563-14566	NN	denotes	Crx
T3466	14566-14567	SYM	denotes	-
T3467	14567-14568	HYPH	denotes	/
T3468	14568-14569	SYM	denotes	-
T3465	14570-14584	NNS	denotes	photoreceptors
T3469	14585-14586	-LRB-	denotes	(
T3470	14586-14593	VB	denotes	compare
T3471	14594-14600	NN	denotes	Figure
T3472	14601-14603	NN	denotes	4F
T3473	14604-14606	IN	denotes	to
T3474	14607-14613	NN	denotes	Figure
T3475	14614-14616	NN	denotes	6A
T3476	14617-14620	CC	denotes	and
T3477	14621-14623	NN	denotes	6B
T3478	14623-14624	-RRB-	denotes	)
T3479	14624-14625	.	denotes	.
T9319	14636-14644	VBG	denotes	Scanning
T9321	14645-14653	NN	denotes	electron
T9320	14654-14664	NN	denotes	microscopy
T9322	14665-14667	IN	denotes	of
T9323	14668-14678	NN	denotes	peripherin
T9325	14678-14679	SYM	denotes	-
T9326	14679-14680	HYPH	denotes	/
T9327	14680-14681	SYM	denotes	-
T9328	14682-14683	-LRB-	denotes	(
T9329	14683-14684	NN	denotes	A
T9330	14684-14685	-RRB-	denotes	)
T9331	14686-14689	CC	denotes	and
T9332	14690-14699	NN	denotes	rhodopsin
T9333	14699-14700	SYM	denotes	-
T9334	14700-14701	HYPH	denotes	/
T9335	14701-14702	SYM	denotes	-
T9336	14703-14704	-LRB-	denotes	(
T9337	14704-14705	NN	denotes	B
T9338	14705-14706	-RRB-	denotes	)
T9324	14707-14721	NNS	denotes	photoreceptors
T9339	14722-14724	IN	denotes	at
T9340	14725-14728	NN	denotes	P21
T9341	14728-14730	,	denotes	,
T9342	14730-14736	VBN	denotes	viewed
T9343	14737-14741	IN	denotes	from
T9344	14742-14745	DT	denotes	the
T9346	14746-14753	JJ	denotes	scleral
T9345	14754-14758	NN	denotes	side
T9347	14759-14763	IN	denotes	with
T9349	14764-14767	DT	denotes	the
T9351	14768-14777	JJ	denotes	pigmented
T9350	14778-14788	NN	denotes	epithelium
T9348	14789-14796	VBN	denotes	removed
T9352	14796-14797	.	denotes	.
T9353	14797-14820	sentence	denotes	cc, connecting cilium.
T9354	14798-14800	NN	denotes	cc
T9355	14800-14802	,	denotes	,
T9356	14802-14812	VBG	denotes	connecting
T9357	14813-14819	NN	denotes	cilium
T9358	14819-14820	.	denotes	.
T9359	14820-14839	sentence	denotes	is, inner segment.
T9360	14821-14823	NN	denotes	is
T9361	14823-14825	,	denotes	,
T9362	14825-14830	JJ	denotes	inner
T9363	14831-14838	NN	denotes	segment
T9364	14838-14839	.	denotes	.
T9365	14839-14858	sentence	denotes	Scale bar = 10 μm.
T9366	14840-14845	NN	denotes	Scale
T9367	14846-14849	NN	denotes	bar
T9369	14850-14851	SYM	denotes	=
T9370	14852-14854	CD	denotes	10
T9368	14855-14857	NN	denotes	μm
T9371	14857-14858	.	denotes	.
T3638	14860-14863	NN	denotes	Crx
T3639	14864-14866	VBZ	denotes	is
T3640	14867-14876	JJ	denotes	necessary
T3641	14877-14880	IN	denotes	for
T3642	14881-14884	DT	denotes	the
T3643	14885-14894	NN	denotes	formation
T3644	14895-14897	IN	denotes	of
T3645	14898-14911	NN	denotes	photoreceptor
T3646	14912-14921	NNS	denotes	terminals
T3647	14921-15136	sentence	denotes	In a previous study, we demonstrated that forced expression of a dominant-negative allele of Crx in developing rods blocked formation of both rod spherules in the outer plexiform layer (OPL) and outer segments [7].
T3648	14922-14924	IN	denotes	In
T3650	14925-14926	DT	denotes	a
T3652	14927-14935	JJ	denotes	previous
T3651	14936-14941	NN	denotes	study
T3653	14941-14943	,	denotes	,
T3654	14943-14945	PRP	denotes	we
T3649	14946-14958	VBD	denotes	demonstrated
T3655	14959-14963	IN	denotes	that
T3657	14964-14970	VBN	denotes	forced
T3658	14971-14981	NN	denotes	expression
T3659	14982-14984	IN	denotes	of
T3660	14985-14986	DT	denotes	a
T3662	14987-14995	JJ	denotes	dominant
T3664	14995-14996	HYPH	denotes	-
T3663	14996-15004	JJ	denotes	negative
T3661	15005-15011	NN	denotes	allele
T3665	15012-15014	IN	denotes	of
T3666	15015-15018	NN	denotes	Crx
T3667	15019-15021	IN	denotes	in
T3668	15022-15032	VBG	denotes	developing
T3669	15033-15037	NNS	denotes	rods
T3656	15038-15045	VBD	denotes	blocked
T3670	15046-15055	NN	denotes	formation
T3671	15056-15058	IN	denotes	of
T3672	15059-15063	DT	denotes	both
T3674	15064-15067	NN	denotes	rod
T3673	15068-15077	NNS	denotes	spherules
T3675	15078-15080	IN	denotes	in
T3676	15081-15084	DT	denotes	the
T3678	15085-15090	JJ	denotes	outer
T3679	15091-15100	NN	denotes	plexiform
T3677	15101-15106	NN	denotes	layer
T3680	15107-15108	-LRB-	denotes	(
T3681	15108-15111	NN	denotes	OPL
T3682	15111-15112	-RRB-	denotes	)
T3683	15113-15116	CC	denotes	and
T3684	15117-15122	JJ	denotes	outer
T3685	15123-15131	NNS	denotes	segments
T3686	15132-15133	-LRB-	denotes	[
T3687	15133-15134	CD	denotes	7
T3688	15134-15135	-RRB-	denotes	]
T3689	15135-15136	.	denotes	.
T3690	15136-15241	sentence	denotes	To expand on these studies, the ultrastructure of photoreceptor synapses was examined in Crx-/- retinas.
T3691	15137-15139	TO	denotes	To
T3692	15140-15146	VB	denotes	expand
T3694	15147-15149	IN	denotes	on
T3695	15150-15155	DT	denotes	these
T3696	15156-15163	NNS	denotes	studies
T3697	15163-15165	,	denotes	,
T3698	15165-15168	DT	denotes	the
T3699	15169-15183	NN	denotes	ultrastructure
T3700	15184-15186	IN	denotes	of
T3701	15187-15200	NN	denotes	photoreceptor
T3702	15201-15209	NNS	denotes	synapses
T3703	15210-15213	VBD	denotes	was
T3693	15214-15222	VBN	denotes	examined
T3704	15223-15225	IN	denotes	in
T3705	15226-15229	NN	denotes	Crx
T3707	15229-15230	SYM	denotes	-
T3708	15230-15231	HYPH	denotes	/
T3709	15231-15232	SYM	denotes	-
T3706	15233-15240	NNS	denotes	retinas
T3710	15240-15241	.	denotes	.
T3711	15241-15321	sentence	denotes	In Crx+/+ retinas at P21, newly mature rod spherules were abundant (Figure 7A).
T3712	15242-15244	IN	denotes	In
T3714	15245-15248	NN	denotes	Crx
T3716	15248-15249	SYM	denotes	+
T3717	15249-15250	HYPH	denotes	/
T3718	15250-15251	SYM	denotes	+
T3715	15252-15259	NNS	denotes	retinas
T3719	15260-15262	IN	denotes	at
T3720	15263-15266	NN	denotes	P21
T3721	15266-15268	,	denotes	,
T3722	15268-15273	RB	denotes	newly
T3723	15274-15280	JJ	denotes	mature
T3725	15281-15284	NN	denotes	rod
T3724	15285-15294	NNS	denotes	spherules
T3713	15295-15299	VBD	denotes	were
T3726	15300-15308	JJ	denotes	abundant
T3727	15309-15310	-LRB-	denotes	(
T3729	15310-15316	NN	denotes	Figure
T3728	15317-15319	NN	denotes	7A
T3730	15319-15320	-RRB-	denotes	)
T3731	15320-15321	.	denotes	.
T3732	15321-15498	sentence	denotes	The sperules were blunt or club-shaped structures with a single ribbon associated with a single invaginating synapse (Figure 7A, arrow indicates one example; Figure 8A and 8B).
T3733	15322-15325	DT	denotes	The
T3734	15326-15334	NNS	denotes	sperules
T3735	15335-15339	VBD	denotes	were
T3736	15340-15345	JJ	denotes	blunt
T3738	15346-15348	CC	denotes	or
T3739	15349-15353	NN	denotes	club
T3741	15353-15354	HYPH	denotes	-
T3740	15354-15360	VBN	denotes	shaped
T3737	15361-15371	NNS	denotes	structures
T3742	15372-15376	IN	denotes	with
T3743	15377-15378	DT	denotes	a
T3745	15379-15385	JJ	denotes	single
T3744	15386-15392	NN	denotes	ribbon
T3746	15393-15403	VBN	denotes	associated
T3747	15404-15408	IN	denotes	with
T3748	15409-15410	DT	denotes	a
T3750	15411-15417	JJ	denotes	single
T3751	15418-15430	VBG	denotes	invaginating
T3749	15431-15438	NN	denotes	synapse
T3752	15439-15440	-LRB-	denotes	(
T3754	15440-15446	NN	denotes	Figure
T3755	15447-15449	NN	denotes	7A
T3756	15449-15451	,	denotes	,
T3757	15451-15456	NN	denotes	arrow
T3758	15457-15466	VBZ	denotes	indicates
T3759	15467-15470	CD	denotes	one
T3760	15471-15478	NN	denotes	example
T3761	15478-15479	:	denotes	;
T3762	15480-15486	NN	denotes	Figure
T3753	15487-15489	NN	denotes	8A
T3763	15490-15493	CC	denotes	and
T3764	15494-15496	NN	denotes	8B
T3765	15496-15497	-RRB-	denotes	)
T3766	15497-15498	.	denotes	.
T3767	15498-15717	sentence	denotes	Two processes from horizontal cells were situated on either side of the synaptic ridge (Figure 8B, labelled H) and one or more dendrites of rod bipolar cells occupied a central position (Figure 8B, bipolar labelled B).
T3768	15499-15502	CD	denotes	Two
T3769	15503-15512	NNS	denotes	processes
T3771	15513-15517	IN	denotes	from
T3772	15518-15528	JJ	denotes	horizontal
T3773	15529-15534	NNS	denotes	cells
T3774	15535-15539	VBD	denotes	were
T3770	15540-15548	VBN	denotes	situated
T3775	15549-15551	IN	denotes	on
T3776	15552-15558	DT	denotes	either
T3777	15559-15563	NN	denotes	side
T3778	15564-15566	IN	denotes	of
T3779	15567-15570	DT	denotes	the
T3781	15571-15579	JJ	denotes	synaptic
T3780	15580-15585	NN	denotes	ridge
T3782	15586-15587	-LRB-	denotes	(
T3784	15587-15593	NN	denotes	Figure
T3783	15594-15596	NN	denotes	8B
T3785	15596-15598	,	denotes	,
T3786	15598-15606	VBN	denotes	labelled
T3787	15607-15608	NN	denotes	H
T3788	15608-15609	-RRB-	denotes	)
T3789	15610-15613	CC	denotes	and
T3790	15614-15617	CD	denotes	one
T3792	15618-15620	CC	denotes	or
T3793	15621-15625	JJR	denotes	more
T3791	15626-15635	NNS	denotes	dendrites
T3795	15636-15638	IN	denotes	of
T3796	15639-15642	NN	denotes	rod
T3798	15643-15650	JJ	denotes	bipolar
T3797	15651-15656	NNS	denotes	cells
T3794	15657-15665	VBD	denotes	occupied
T3799	15666-15667	DT	denotes	a
T3801	15668-15675	JJ	denotes	central
T3800	15676-15684	NN	denotes	position
T3802	15685-15686	-LRB-	denotes	(
T3804	15686-15692	NN	denotes	Figure
T3805	15693-15695	NN	denotes	8B
T3806	15695-15697	,	denotes	,
T3807	15697-15704	JJ	denotes	bipolar
T3808	15705-15713	VBN	denotes	labelled
T3803	15714-15715	NN	denotes	B
T3809	15715-15716	-RRB-	denotes	)
T3810	15716-15717	.	denotes	.
T3811	15717-15864	sentence	denotes	Cone terminals are large, flat pedicles that exhibit many invaginating synapses containing separate sets of horizontal and bipolar cell processes.
T3812	15718-15722	NN	denotes	Cone
T3813	15723-15732	NNS	denotes	terminals
T3814	15733-15736	VBP	denotes	are
T3815	15737-15742	JJ	denotes	large
T3817	15742-15744	,	denotes	,
T3816	15744-15748	JJ	denotes	flat
T3818	15749-15757	NNS	denotes	pedicles
T3819	15758-15762	WDT	denotes	that
T3820	15763-15770	VBP	denotes	exhibit
T3821	15771-15775	JJ	denotes	many
T3823	15776-15788	VBG	denotes	invaginating
T3822	15789-15797	NNS	denotes	synapses
T3824	15798-15808	VBG	denotes	containing
T3825	15809-15817	JJ	denotes	separate
T3826	15818-15822	NNS	denotes	sets
T3827	15823-15825	IN	denotes	of
T3828	15826-15836	JJ	denotes	horizontal
T3830	15837-15840	CC	denotes	and
T3831	15841-15848	JJ	denotes	bipolar
T3832	15849-15853	NN	denotes	cell
T3829	15854-15863	NNS	denotes	processes
T3833	15863-15864	.	denotes	.
T3834	15864-15904	sentence	denotes	Each pedicle contains numerous ribbons.
T3835	15865-15869	DT	denotes	Each
T3836	15870-15877	NN	denotes	pedicle
T3837	15878-15886	VBZ	denotes	contains
T3838	15887-15895	JJ	denotes	numerous
T3839	15896-15903	NNS	denotes	ribbons
T3840	15903-15904	.	denotes	.
T3841	15904-15999	sentence	denotes	These terminals were much less common than spherules in Crx+/+ retinas at P21 (Figure 7, box).
T3842	15905-15910	DT	denotes	These
T3843	15911-15920	NNS	denotes	terminals
T3844	15921-15925	VBD	denotes	were
T3845	15926-15930	RB	denotes	much
T3846	15931-15935	RBR	denotes	less
T3847	15936-15942	JJ	denotes	common
T3848	15943-15947	IN	denotes	than
T3849	15948-15957	NNS	denotes	spherules
T3850	15958-15960	IN	denotes	in
T3851	15961-15964	NN	denotes	Crx
T3853	15964-15965	SYM	denotes	+
T3854	15965-15966	HYPH	denotes	/
T3855	15966-15967	SYM	denotes	+
T3852	15968-15975	NNS	denotes	retinas
T3856	15976-15978	IN	denotes	at
T3857	15979-15982	NN	denotes	P21
T3858	15983-15984	-LRB-	denotes	(
T3860	15984-15990	NN	denotes	Figure
T3861	15991-15992	CD	denotes	7
T3862	15992-15994	,	denotes	,
T3859	15994-15997	NN	denotes	box
T3863	15997-15998	-RRB-	denotes	)
T3864	15998-15999	.	denotes	.
T3865	15999-16106	sentence	denotes	In the OPL of Crx-/- retinas, photoreceptor terminals were highly disorganized at P21 (Figure 7B, arrows).
T3866	16000-16002	IN	denotes	In
T3868	16003-16006	DT	denotes	the
T3869	16007-16010	NN	denotes	OPL
T3870	16011-16013	IN	denotes	of
T3871	16014-16017	NN	denotes	Crx
T3873	16017-16018	SYM	denotes	-
T3874	16018-16019	HYPH	denotes	/
T3875	16019-16020	SYM	denotes	-
T3872	16021-16028	NNS	denotes	retinas
T3876	16028-16030	,	denotes	,
T3877	16030-16043	NN	denotes	photoreceptor
T3878	16044-16053	NNS	denotes	terminals
T3867	16054-16058	VBD	denotes	were
T3879	16059-16065	RB	denotes	highly
T3880	16066-16078	JJ	denotes	disorganized
T3881	16079-16081	IN	denotes	at
T3882	16082-16085	NN	denotes	P21
T3883	16086-16087	-LRB-	denotes	(
T3885	16087-16093	NN	denotes	Figure
T3886	16094-16096	NN	denotes	7B
T3887	16096-16098	,	denotes	,
T3884	16098-16104	NNS	denotes	arrows
T3888	16104-16105	-RRB-	denotes	)
T3889	16105-16106	.	denotes	.
T3890	16106-16249	sentence	denotes	Processes containing synaptic vesicles and ribbon-like structures were apparent, suggesting at least limited generation of synapse components.
T3891	16107-16116	NNS	denotes	Processes
T3893	16117-16127	VBG	denotes	containing
T3894	16128-16136	JJ	denotes	synaptic
T3895	16137-16145	NNS	denotes	vesicles
T3896	16146-16149	CC	denotes	and
T3897	16150-16156	NN	denotes	ribbon
T3899	16156-16157	HYPH	denotes	-
T3898	16157-16161	JJ	denotes	like
T3900	16162-16172	NNS	denotes	structures
T3892	16173-16177	VBD	denotes	were
T3901	16178-16186	JJ	denotes	apparent
T3902	16186-16188	,	denotes	,
T3903	16188-16198	VBG	denotes	suggesting
T3904	16199-16201	RB	denotes	at
T3905	16202-16207	RBS	denotes	least
T3906	16208-16215	JJ	denotes	limited
T3907	16216-16226	NN	denotes	generation
T3908	16227-16229	IN	denotes	of
T3909	16230-16237	NN	denotes	synapse
T3910	16238-16248	NNS	denotes	components
T3911	16248-16249	.	denotes	.
T3912	16249-16312	sentence	denotes	However, well formed spherules and pedicles were not observed.
T3913	16250-16257	RB	denotes	However
T3915	16257-16259	,	denotes	,
T3916	16259-16263	RB	denotes	well
T3917	16264-16270	VBN	denotes	formed
T3918	16271-16280	NNS	denotes	spherules
T3919	16281-16284	CC	denotes	and
T3920	16285-16293	NNS	denotes	pedicles
T3921	16294-16298	VBD	denotes	were
T3922	16299-16302	RB	denotes	not
T3914	16303-16311	VBN	denotes	observed
T3923	16311-16312	.	denotes	.
T3924	16312-16490	sentence	denotes	In addition, many terminals appeared to contain multiple ribbons (Figure 8C and 8D, r) not tethered to the plasma membrane and occasionally in perinuclear positions (Figure 8D).
T3925	16313-16315	IN	denotes	In
T3927	16316-16324	NN	denotes	addition
T3928	16324-16326	,	denotes	,
T3929	16326-16330	JJ	denotes	many
T3930	16331-16340	NNS	denotes	terminals
T3926	16341-16349	VBD	denotes	appeared
T3931	16350-16352	TO	denotes	to
T3932	16353-16360	VB	denotes	contain
T3933	16361-16369	JJ	denotes	multiple
T3934	16370-16377	NNS	denotes	ribbons
T3935	16378-16379	-LRB-	denotes	(
T3937	16379-16385	NN	denotes	Figure
T3938	16386-16388	NN	denotes	8C
T3939	16389-16392	CC	denotes	and
T3940	16393-16395	NN	denotes	8D
T3941	16395-16397	,	denotes	,
T3936	16397-16398	NN	denotes	r
T3942	16398-16399	-RRB-	denotes	)
T3943	16400-16403	RB	denotes	not
T3944	16404-16412	VBN	denotes	tethered
T3945	16413-16415	IN	denotes	to
T3946	16416-16419	DT	denotes	the
T3948	16420-16426	NN	denotes	plasma
T3947	16427-16435	NN	denotes	membrane
T3949	16436-16439	CC	denotes	and
T3950	16440-16452	RB	denotes	occasionally
T3951	16453-16455	IN	denotes	in
T3952	16456-16467	JJ	denotes	perinuclear
T3953	16468-16477	NNS	denotes	positions
T3954	16478-16479	-LRB-	denotes	(
T3956	16479-16485	NN	denotes	Figure
T3955	16486-16488	NN	denotes	8D
T3957	16488-16489	-RRB-	denotes	)
T3958	16489-16490	.	denotes	.
T9460	16501-16513	NN	denotes	Transmission
T9462	16514-16522	NN	denotes	electron
T9461	16523-16534	NNS	denotes	micrographs
T9463	16535-16537	IN	denotes	of
T9464	16538-16541	DT	denotes	the
T9466	16542-16547	JJ	denotes	outer
T9467	16548-16557	NN	denotes	plexiform
T9465	16558-16563	NN	denotes	layer
T9468	16564-16566	IN	denotes	in
T9469	16567-16570	NN	denotes	Crx
T9471	16570-16571	SYM	denotes	-
T9472	16571-16572	HYPH	denotes	/
T9473	16572-16573	SYM	denotes	-
T9470	16574-16581	NNS	denotes	retinas
T9474	16581-16582	.	denotes	.
T9475	16582-16686	sentence	denotes	(A) In Crx+/+ retina at P21, newly formed rod spherules were abundant (arrow demonstrates one example).
T9476	16583-16584	-LRB-	denotes	(
T9477	16584-16585	LS	denotes	A
T9479	16585-16586	-RRB-	denotes	)
T9480	16587-16589	IN	denotes	In
T9481	16590-16593	NN	denotes	Crx
T9483	16593-16594	SYM	denotes	+
T9484	16594-16595	HYPH	denotes	/
T9485	16595-16596	SYM	denotes	+
T9482	16597-16603	NN	denotes	retina
T9486	16604-16606	IN	denotes	at
T9487	16607-16610	NN	denotes	P21
T9488	16610-16612	,	denotes	,
T9489	16612-16617	RB	denotes	newly
T9490	16618-16624	VBN	denotes	formed
T9492	16625-16628	NN	denotes	rod
T9491	16629-16638	NNS	denotes	spherules
T9478	16639-16643	VBD	denotes	were
T9493	16644-16652	JJ	denotes	abundant
T9494	16653-16654	-LRB-	denotes	(
T9496	16654-16659	NN	denotes	arrow
T9495	16660-16672	VBZ	denotes	demonstrates
T9497	16673-16676	CD	denotes	one
T9498	16677-16684	NN	denotes	example
T9499	16684-16685	-RRB-	denotes	)
T9500	16685-16686	.	denotes	.
T9501	16686-16786	sentence	denotes	The spherules were club-shaped and contained a single invaginating synapse with one ribbon complex.
T9502	16687-16690	DT	denotes	The
T9503	16691-16700	NNS	denotes	spherules
T9504	16701-16705	VBD	denotes	were
T9505	16706-16710	NN	denotes	club
T9507	16710-16711	HYPH	denotes	-
T9506	16711-16717	VBN	denotes	shaped
T9508	16718-16721	CC	denotes	and
T9509	16722-16731	VBD	denotes	contained
T9510	16732-16733	DT	denotes	a
T9512	16734-16740	JJ	denotes	single
T9513	16741-16753	VBG	denotes	invaginating
T9511	16754-16761	NN	denotes	synapse
T9514	16762-16766	IN	denotes	with
T9515	16767-16770	CD	denotes	one
T9517	16771-16777	NN	denotes	ribbon
T9516	16778-16785	NN	denotes	complex
T9518	16785-16786	.	denotes	.
T9519	16786-16900	sentence	denotes	Cone terminals form large, flat pedicles that contain many invaginating synapses with separate ribbon structures.
T9520	16787-16791	NN	denotes	Cone
T9521	16792-16801	NNS	denotes	terminals
T9522	16802-16806	VBP	denotes	form
T9523	16807-16812	JJ	denotes	large
T9525	16812-16814	,	denotes	,
T9526	16814-16818	JJ	denotes	flat
T9524	16819-16827	NNS	denotes	pedicles
T9527	16828-16832	WDT	denotes	that
T9528	16833-16840	VBP	denotes	contain
T9529	16841-16845	JJ	denotes	many
T9531	16846-16858	VBG	denotes	invaginating
T9530	16859-16867	NNS	denotes	synapses
T9532	16868-16872	IN	denotes	with
T9533	16873-16881	JJ	denotes	separate
T9535	16882-16888	NN	denotes	ribbon
T9534	16889-16899	NNS	denotes	structures
T9536	16899-16900	.	denotes	.
T9537	16900-16994	sentence	denotes	These terminals were more scarce, but apparent in Crx+/+ retinas at P21 (one example in box).
T9538	16901-16906	DT	denotes	These
T9539	16907-16916	NNS	denotes	terminals
T9540	16917-16921	VBD	denotes	were
T9541	16922-16926	RBR	denotes	more
T9542	16927-16933	JJ	denotes	scarce
T9543	16933-16935	,	denotes	,
T9544	16935-16938	CC	denotes	but
T9545	16939-16947	JJ	denotes	apparent
T9546	16948-16950	IN	denotes	in
T9547	16951-16954	NN	denotes	Crx
T9549	16954-16955	SYM	denotes	+
T9550	16955-16956	HYPH	denotes	/
T9551	16956-16957	SYM	denotes	+
T9548	16958-16965	NNS	denotes	retinas
T9552	16966-16968	IN	denotes	at
T9553	16969-16972	NN	denotes	P21
T9554	16973-16974	-LRB-	denotes	(
T9556	16974-16977	CD	denotes	one
T9555	16978-16985	NN	denotes	example
T9557	16986-16988	IN	denotes	in
T9558	16989-16992	NN	denotes	box
T9559	16992-16993	-RRB-	denotes	)
T9560	16993-16994	.	denotes	.
T9561	16994-17122	sentence	denotes	(B) In the outer plexiform layer (OPL) of Crx-/- retinas, photoreceptor terminals appeared highly disorganized at P21 (arrows).
T9562	16995-16996	-LRB-	denotes	(
T9563	16996-16997	LS	denotes	B
T9565	16997-16998	-RRB-	denotes	)
T9566	16999-17001	IN	denotes	In
T9567	17002-17005	DT	denotes	the
T9569	17006-17011	JJ	denotes	outer
T9570	17012-17021	NN	denotes	plexiform
T9568	17022-17027	NN	denotes	layer
T9571	17028-17029	-LRB-	denotes	(
T9572	17029-17032	NN	denotes	OPL
T9573	17032-17033	-RRB-	denotes	)
T9574	17034-17036	IN	denotes	of
T9575	17037-17040	NN	denotes	Crx
T9577	17040-17041	SYM	denotes	-
T9578	17041-17042	HYPH	denotes	/
T9579	17042-17043	SYM	denotes	-
T9576	17044-17051	NNS	denotes	retinas
T9580	17051-17053	,	denotes	,
T9581	17053-17066	NN	denotes	photoreceptor
T9582	17067-17076	NNS	denotes	terminals
T9564	17077-17085	VBD	denotes	appeared
T9583	17086-17092	RB	denotes	highly
T9584	17093-17105	JJ	denotes	disorganized
T9585	17106-17108	IN	denotes	at
T9586	17109-17112	NN	denotes	P21
T9587	17113-17114	-LRB-	denotes	(
T9588	17114-17120	NNS	denotes	arrows
T9589	17120-17121	-RRB-	denotes	)
T9590	17121-17122	.	denotes	.
T9591	17122-17175	sentence	denotes	Well-formed pedicles and spherules were not evident.
T9592	17123-17127	RB	denotes	Well
T9594	17127-17128	HYPH	denotes	-
T9593	17128-17134	VBN	denotes	formed
T9595	17135-17143	NNS	denotes	pedicles
T9597	17144-17147	CC	denotes	and
T9598	17148-17157	NNS	denotes	spherules
T9596	17158-17162	VBD	denotes	were
T9599	17163-17166	RB	denotes	not
T9600	17167-17174	JJ	denotes	evident
T9601	17174-17175	.	denotes	.
T9602	17175-17305	sentence	denotes	Putative terminals containing ribbon-like structures were apparent, suggesting at least limited generation of synapse components.
T9603	17176-17184	JJ	denotes	Putative
T9604	17185-17194	NNS	denotes	terminals
T9606	17195-17205	VBG	denotes	containing
T9607	17206-17212	NN	denotes	ribbon
T9609	17212-17213	HYPH	denotes	-
T9608	17213-17217	JJ	denotes	like
T9610	17218-17228	NNS	denotes	structures
T9605	17229-17233	VBD	denotes	were
T9611	17234-17242	JJ	denotes	apparent
T9612	17242-17244	,	denotes	,
T9613	17244-17254	VBG	denotes	suggesting
T9614	17255-17257	RB	denotes	at
T9615	17258-17263	RBS	denotes	least
T9616	17264-17271	JJ	denotes	limited
T9617	17272-17282	NN	denotes	generation
T9618	17283-17285	IN	denotes	of
T9619	17286-17293	NN	denotes	synapse
T9620	17294-17304	NNS	denotes	components
T9621	17304-17305	.	denotes	.
T9622	17305-17402	sentence	denotes	Many terminals appeared to contain multiple ribbon-like structures, instead of a singule ribbon.
T9623	17306-17310	JJ	denotes	Many
T9624	17311-17320	NNS	denotes	terminals
T9625	17321-17329	VBD	denotes	appeared
T9626	17330-17332	TO	denotes	to
T9627	17333-17340	VB	denotes	contain
T9628	17341-17349	JJ	denotes	multiple
T9630	17350-17356	NN	denotes	ribbon
T9632	17356-17357	HYPH	denotes	-
T9631	17357-17361	JJ	denotes	like
T9629	17362-17372	NNS	denotes	structures
T9633	17372-17374	,	denotes	,
T9634	17374-17381	RB	denotes	instead
T9635	17382-17384	IN	denotes	of
T9636	17385-17386	DT	denotes	a
T9638	17387-17394	JJ	denotes	singule
T9637	17395-17401	NN	denotes	ribbon
T9639	17401-17402	.	denotes	.
T9640	17402-17509	sentence	denotes	For example, terminal 1 and 2 contained two ribbons each, whereas terminal 3 appeared to contain only one.
T9641	17403-17406	IN	denotes	For
T9643	17407-17414	NN	denotes	example
T9644	17414-17416	,	denotes	,
T9645	17416-17424	NN	denotes	terminal
T9646	17425-17426	CD	denotes	1
T9647	17427-17430	CC	denotes	and
T9648	17431-17432	CD	denotes	2
T9642	17433-17442	VBD	denotes	contained
T9649	17443-17446	CD	denotes	two
T9650	17447-17454	NNS	denotes	ribbons
T9651	17455-17459	DT	denotes	each
T9652	17459-17461	,	denotes	,
T9653	17461-17468	IN	denotes	whereas
T9655	17469-17477	NN	denotes	terminal
T9656	17478-17479	CD	denotes	3
T9654	17480-17488	VBD	denotes	appeared
T9657	17489-17491	TO	denotes	to
T9658	17492-17499	VB	denotes	contain
T9659	17500-17504	RB	denotes	only
T9660	17505-17508	CD	denotes	one
T9661	17508-17509	.	denotes	.
T9662	17509-17537	sentence	denotes	opl, outer plexiform layer.
T9663	17510-17513	NN	denotes	opl
T9664	17513-17515	,	denotes	,
T9665	17515-17520	JJ	denotes	outer
T9667	17521-17530	NN	denotes	plexiform
T9666	17531-17536	NN	denotes	layer
T9668	17536-17537	.	denotes	.
T9669	17537-17555	sentence	denotes	Scale bar = 2 μm.
T9670	17538-17543	NN	denotes	Scale
T9671	17544-17547	NN	denotes	bar
T9673	17548-17549	SYM	denotes	=
T9674	17550-17551	CD	denotes	2
T9672	17552-17554	NN	denotes	μm
T9675	17554-17555	.	denotes	.
T9811	17566-17578	NN	denotes	Transmission
T9813	17579-17587	NN	denotes	electron
T9812	17588-17599	NNS	denotes	micrographs
T9814	17600-17602	IN	denotes	of
T9815	17603-17606	DT	denotes	the
T9817	17607-17612	JJ	denotes	outer
T9818	17613-17622	NN	denotes	plexiform
T9816	17623-17628	NN	denotes	layer
T9819	17629-17631	IN	denotes	in
T9820	17632-17635	NN	denotes	Crx
T9822	17635-17636	SYM	denotes	-
T9823	17636-17637	HYPH	denotes	/
T9824	17637-17638	SYM	denotes	-
T9821	17639-17646	NNS	denotes	retinas
T9825	17647-17649	IN	denotes	at
T9826	17650-17653	NN	denotes	P21
T9827	17653-17654	.	denotes	.
T9828	17654-17744	sentence	denotes	(A) Crx+/+ rod spherules contained a single invaginating synapse with one ribbon complex.
T9829	17655-17656	-LRB-	denotes	(
T9830	17656-17657	LS	denotes	A
T9832	17657-17658	-RRB-	denotes	)
T9833	17659-17662	NN	denotes	Crx
T9835	17662-17663	SYM	denotes	+
T9836	17663-17664	HYPH	denotes	/
T9837	17664-17665	SYM	denotes	+
T9838	17666-17669	NN	denotes	rod
T9834	17670-17679	NNS	denotes	spherules
T9831	17680-17689	VBD	denotes	contained
T9839	17690-17691	DT	denotes	a
T9841	17692-17698	JJ	denotes	single
T9842	17699-17711	VBG	denotes	invaginating
T9840	17712-17719	NN	denotes	synapse
T9843	17720-17724	IN	denotes	with
T9844	17725-17728	CD	denotes	one
T9846	17729-17735	NN	denotes	ribbon
T9845	17736-17743	NN	denotes	complex
T9847	17743-17744	.	denotes	.
T9848	17744-17795	sentence	denotes	The spherule was a blunt or club-shaped structure.
T9849	17745-17748	DT	denotes	The
T9850	17749-17757	NN	denotes	spherule
T9851	17758-17761	VBD	denotes	was
T9852	17762-17763	DT	denotes	a
T9854	17764-17769	JJ	denotes	blunt
T9855	17770-17772	CC	denotes	or
T9856	17773-17777	NN	denotes	club
T9858	17777-17778	HYPH	denotes	-
T9857	17778-17784	VBN	denotes	shaped
T9853	17785-17794	NN	denotes	structure
T9859	17794-17795	.	denotes	.
T9860	17795-17861	sentence	denotes	(B) Crx+/+ rod terminals contained a single ribbon structure (r).
T9861	17796-17797	-LRB-	denotes	(
T9862	17797-17798	LS	denotes	B
T9864	17798-17799	-RRB-	denotes	)
T9865	17800-17803	NN	denotes	Crx
T9867	17803-17804	SYM	denotes	+
T9868	17804-17805	HYPH	denotes	/
T9869	17805-17806	SYM	denotes	+
T9870	17807-17810	NN	denotes	rod
T9866	17811-17820	NNS	denotes	terminals
T9863	17821-17830	VBD	denotes	contained
T9871	17831-17832	DT	denotes	a
T9873	17833-17839	JJ	denotes	single
T9874	17840-17846	NN	denotes	ribbon
T9872	17847-17856	NN	denotes	structure
T9875	17857-17858	-LRB-	denotes	(
T9876	17858-17859	NN	denotes	r
T9877	17859-17860	-RRB-	denotes	)
T9878	17860-17861	.	denotes	.
T9879	17861-17932	sentence	denotes	Two processes, from horizontal cells (h), contacted the rod laterally.
T9880	17862-17865	CD	denotes	Two
T9881	17866-17875	NNS	denotes	processes
T9883	17875-17877	,	denotes	,
T9884	17877-17881	IN	denotes	from
T9885	17882-17892	JJ	denotes	horizontal
T9886	17893-17898	NNS	denotes	cells
T9887	17899-17900	-LRB-	denotes	(
T9888	17900-17901	NN	denotes	h
T9889	17901-17902	-RRB-	denotes	)
T9890	17902-17904	,	denotes	,
T9882	17904-17913	VBD	denotes	contacted
T9891	17914-17917	DT	denotes	the
T9892	17918-17921	NN	denotes	rod
T9893	17922-17931	RB	denotes	laterally
T9894	17931-17932	.	denotes	.
T9895	17932-18023	sentence	denotes	An additional process, the postsynaptic bipolar dendrite (b), was situated more centrally.
T9896	17933-17935	DT	denotes	An
T9898	17936-17946	JJ	denotes	additional
T9897	17947-17954	NN	denotes	process
T9900	17954-17956	,	denotes	,
T9901	17956-17959	DT	denotes	the
T9903	17960-17972	JJ	denotes	postsynaptic
T9904	17973-17980	JJ	denotes	bipolar
T9902	17981-17989	NN	denotes	dendrite
T9905	17990-17991	-LRB-	denotes	(
T9906	17991-17992	NN	denotes	b
T9907	17992-17993	-RRB-	denotes	)
T9908	17993-17995	,	denotes	,
T9909	17995-17998	VBD	denotes	was
T9899	17999-18007	VBN	denotes	situated
T9910	18008-18012	RBR	denotes	more
T9911	18013-18022	RB	denotes	centrally
T9912	18022-18023	.	denotes	.
T9913	18023-18069	sentence	denotes	Terminals were filled with synaptic vesicles.
T9914	18024-18033	NNS	denotes	Terminals
T9916	18034-18038	VBD	denotes	were
T9915	18039-18045	VBN	denotes	filled
T9917	18046-18050	IN	denotes	with
T9918	18051-18059	JJ	denotes	synaptic
T9919	18060-18068	NNS	denotes	vesicles
T9920	18068-18069	.	denotes	.
T9921	18069-18145	sentence	denotes	One coated vesicle originatinf from the cell membrane was observed (arrow).
T9922	18070-18073	CD	denotes	One
T9924	18074-18080	JJ	denotes	coated
T9923	18081-18088	NN	denotes	vesicle
T9926	18089-18100	VBG	denotes	originatinf
T9927	18101-18105	IN	denotes	from
T9928	18106-18109	DT	denotes	the
T9930	18110-18114	NN	denotes	cell
T9929	18115-18123	NN	denotes	membrane
T9931	18124-18127	VBD	denotes	was
T9925	18128-18136	VBN	denotes	observed
T9932	18137-18138	-LRB-	denotes	(
T9933	18138-18143	NN	denotes	arrow
T9934	18143-18144	-RRB-	denotes	)
T9935	18144-18145	.	denotes	.
T9936	18145-18233	sentence	denotes	(C) In the OPL of Crx-/- retinas, photoreceptor terminals appeared highly disorganized.
T9937	18146-18147	-LRB-	denotes	(
T9938	18147-18148	LS	denotes	C
T9940	18148-18149	-RRB-	denotes	)
T9941	18150-18152	IN	denotes	In
T9942	18153-18156	DT	denotes	the
T9943	18157-18160	NN	denotes	OPL
T9944	18161-18163	IN	denotes	of
T9945	18164-18167	NN	denotes	Crx
T9947	18167-18168	SYM	denotes	-
T9948	18168-18169	HYPH	denotes	/
T9949	18169-18170	SYM	denotes	-
T9946	18171-18178	NNS	denotes	retinas
T9950	18178-18180	,	denotes	,
T9951	18180-18193	NN	denotes	photoreceptor
T9952	18194-18203	NNS	denotes	terminals
T9939	18204-18212	VBD	denotes	appeared
T9953	18213-18219	RB	denotes	highly
T9954	18220-18232	JJ	denotes	disorganized
T9955	18232-18233	.	denotes	.
T9956	18233-18394	sentence	denotes	Putative terminals containing synaptic vesicles and ribbon-like structures were apparent (arrows), suggesting at least limited generation of synapse components.
T9957	18234-18242	JJ	denotes	Putative
T9958	18243-18252	NNS	denotes	terminals
T9960	18253-18263	VBG	denotes	containing
T9961	18264-18272	JJ	denotes	synaptic
T9962	18273-18281	NNS	denotes	vesicles
T9963	18282-18285	CC	denotes	and
T9964	18286-18292	NN	denotes	ribbon
T9966	18292-18293	HYPH	denotes	-
T9965	18293-18297	JJ	denotes	like
T9967	18298-18308	NNS	denotes	structures
T9959	18309-18313	VBD	denotes	were
T9968	18314-18322	JJ	denotes	apparent
T9969	18323-18324	-LRB-	denotes	(
T9970	18324-18330	NNS	denotes	arrows
T9971	18330-18331	-RRB-	denotes	)
T9972	18331-18333	,	denotes	,
T9973	18333-18343	VBG	denotes	suggesting
T9974	18344-18346	RB	denotes	at
T9975	18347-18352	RBS	denotes	least
T9976	18353-18360	JJ	denotes	limited
T9977	18361-18371	NN	denotes	generation
T9978	18372-18374	IN	denotes	of
T9979	18375-18382	NN	denotes	synapse
T9980	18383-18393	NNS	denotes	components
T9981	18393-18394	.	denotes	.
T9982	18394-18457	sentence	denotes	However, well formed spherules and pedicles were not observed.
T9983	18395-18402	RB	denotes	However
T9985	18402-18404	,	denotes	,
T9986	18404-18408	RB	denotes	well
T9987	18409-18415	VBN	denotes	formed
T9988	18416-18425	NNS	denotes	spherules
T9989	18426-18429	CC	denotes	and
T9990	18430-18438	NNS	denotes	pedicles
T9991	18439-18443	VBD	denotes	were
T9992	18444-18447	RB	denotes	not
T9984	18448-18456	VBN	denotes	observed
T9993	18456-18457	.	denotes	.
T9994	18457-18538	sentence	denotes	Further, many terminals appeared to contain multiple ribbon-like structures (r).
T9995	18458-18465	RB	denotes	Further
T9997	18465-18467	,	denotes	,
T9998	18467-18471	JJ	denotes	many
T9999	18472-18481	NNS	denotes	terminals
T9996	18482-18490	VBD	denotes	appeared
T10000	18491-18493	TO	denotes	to
T10001	18494-18501	VB	denotes	contain
T10002	18502-18510	JJ	denotes	multiple
T10004	18511-18517	NN	denotes	ribbon
T10006	18517-18518	HYPH	denotes	-
T10005	18518-18522	JJ	denotes	like
T10003	18523-18533	NNS	denotes	structures
T10007	18534-18535	-LRB-	denotes	(
T10008	18535-18536	NN	denotes	r
T10009	18536-18537	-RRB-	denotes	)
T10010	18537-18538	.	denotes	.
T10011	18538-18706	sentence	denotes	The majority of these ribbons were not associated with the synaptic membrane, but instead were found free floating and, in some instances, were perinuclear (D, arrow).
T10012	18539-18542	DT	denotes	The
T10013	18543-18551	NN	denotes	majority
T10015	18552-18554	IN	denotes	of
T10016	18555-18560	DT	denotes	these
T10017	18561-18568	NNS	denotes	ribbons
T10018	18569-18573	VBD	denotes	were
T10019	18574-18577	RB	denotes	not
T10014	18578-18588	VBN	denotes	associated
T10020	18589-18593	IN	denotes	with
T10021	18594-18597	DT	denotes	the
T10023	18598-18606	JJ	denotes	synaptic
T10022	18607-18615	NN	denotes	membrane
T10024	18615-18617	,	denotes	,
T10025	18617-18620	CC	denotes	but
T10026	18621-18628	RB	denotes	instead
T10027	18629-18633	VBD	denotes	were
T10028	18634-18639	VBN	denotes	found
T10029	18640-18644	JJ	denotes	free
T10030	18645-18653	VBG	denotes	floating
T10031	18654-18657	CC	denotes	and
T10032	18657-18659	,	denotes	,
T10033	18659-18661	IN	denotes	in
T10035	18662-18666	DT	denotes	some
T10036	18667-18676	NNS	denotes	instances
T10037	18676-18678	,	denotes	,
T10034	18678-18682	VBD	denotes	were
T10038	18683-18694	JJ	denotes	perinuclear
T10039	18695-18696	-LRB-	denotes	(
T10041	18696-18697	NN	denotes	D
T10042	18697-18699	,	denotes	,
T10040	18699-18704	NN	denotes	arrow
T10043	18704-18705	-RRB-	denotes	)
T10044	18705-18706	.	denotes	.
T10045	18706-18766	sentence	denotes	H, horizontal cell; B, bipolar cell; N, nucleus; r, ribbon.
T10046	18707-18708	NN	denotes	H
T10047	18708-18710	,	denotes	,
T10048	18710-18720	JJ	denotes	horizontal
T10049	18721-18725	NN	denotes	cell
T10050	18725-18726	:	denotes	;
T10051	18727-18728	NN	denotes	B
T10052	18728-18730	,	denotes	,
T10053	18730-18737	JJ	denotes	bipolar
T10054	18738-18742	NN	denotes	cell
T10055	18742-18743	:	denotes	;
T10056	18744-18745	NN	denotes	N
T10057	18745-18747	,	denotes	,
T10058	18747-18754	NN	denotes	nucleus
T10059	18754-18755	:	denotes	;
T10060	18756-18757	NN	denotes	r
T10061	18757-18759	,	denotes	,
T10062	18759-18765	NN	denotes	ribbon
T10063	18765-18766	.	denotes	.
T10064	18766-18844	sentence	denotes	(A) Scale bar = 500 nm, (B) Scale bar = 250 nm, (C and D) Scale bar = 500 nm.
T10065	18767-18768	-LRB-	denotes	(
T10066	18768-18769	LS	denotes	A
T10068	18769-18770	-RRB-	denotes	)
T10069	18771-18776	NN	denotes	Scale
T10070	18777-18780	NN	denotes	bar
T10071	18781-18782	SYM	denotes	=
T10072	18783-18786	CD	denotes	500
T10067	18787-18789	NN	denotes	nm
T10074	18789-18791	,	denotes	,
T10075	18791-18792	-LRB-	denotes	(
T10076	18792-18793	LS	denotes	B
T10078	18793-18794	-RRB-	denotes	)
T10079	18795-18800	NN	denotes	Scale
T10080	18801-18804	NN	denotes	bar
T10081	18805-18806	SYM	denotes	=
T10082	18807-18810	CD	denotes	250
T10077	18811-18813	NN	denotes	nm
T10083	18813-18815	,	denotes	,
T10084	18815-18816	-LRB-	denotes	(
T10085	18816-18817	LS	denotes	C
T10086	18818-18821	CC	denotes	and
T10087	18822-18823	LS	denotes	D
T10088	18823-18824	-RRB-	denotes	)
T10089	18825-18830	NN	denotes	Scale
T10090	18831-18834	NN	denotes	bar
T10091	18835-18836	SYM	denotes	=
T10092	18837-18840	CD	denotes	500
T10073	18841-18843	NN	denotes	nm
T10093	18843-18844	.	denotes	.
T4008	18857-18859	IN	denotes	In
T4010	18860-18864	DT	denotes	this
T4011	18865-18870	NN	denotes	study
T4012	18870-18872	,	denotes	,
T4013	18872-18874	DT	denotes	an
T4015	18875-18890	JJ	denotes	ultrastructural
T4014	18891-18899	NN	denotes	analysis
T4016	18900-18902	IN	denotes	of
T4017	18903-18906	NN	denotes	Crx
T4019	18906-18907	SYM	denotes	-
T4020	18907-18908	HYPH	denotes	/
T4021	18908-18909	SYM	denotes	-
T4018	18910-18924	NNS	denotes	photoreceptors
T4022	18925-18928	VBD	denotes	was
T4009	18929-18936	VBN	denotes	carried
T4023	18937-18940	RP	denotes	out
T4024	18940-18941	.	denotes	.
T4025	18941-19101	sentence	denotes	As Crx mutations have been associated with Leber's congenital amaurosis, the findings in this study broaden our understanding of the pathology of this disease.
T4026	18942-18944	IN	denotes	As
T4028	18945-18948	NN	denotes	Crx
T4029	18949-18958	NNS	denotes	mutations
T4030	18959-18963	VBP	denotes	have
T4031	18964-18968	VBN	denotes	been
T4027	18969-18979	VBN	denotes	associated
T4033	18980-18984	IN	denotes	with
T4034	18985-18990	NNP	denotes	Leber
T4036	18990-18992	POS	denotes	's
T4037	18993-19003	JJ	denotes	congenital
T4035	19004-19013	NN	denotes	amaurosis
T4038	19013-19015	,	denotes	,
T4039	19015-19018	DT	denotes	the
T4040	19019-19027	NNS	denotes	findings
T4041	19028-19030	IN	denotes	in
T4042	19031-19035	DT	denotes	this
T4043	19036-19041	NN	denotes	study
T4032	19042-19049	VBD	denotes	broaden
T4044	19050-19053	PRP$	denotes	our
T4045	19054-19067	NN	denotes	understanding
T4046	19068-19070	IN	denotes	of
T4047	19071-19074	DT	denotes	the
T4048	19075-19084	NN	denotes	pathology
T4049	19085-19087	IN	denotes	of
T4050	19088-19092	DT	denotes	this
T4051	19093-19100	NN	denotes	disease
T4052	19100-19101	.	denotes	.
T4053	19101-19388	sentence	denotes	Two prominent pathologies were characterized in the Crx-/- retina: (1) An absolute block in outer segment morphogenesis was noted, with the block occuring at the elongation stage of outer segment formation; (2) Crx-/- photoreceptors exhibited a severe perturbation in synapse formation.
T4054	19102-19105	CD	denotes	Two
T4056	19106-19115	JJ	denotes	prominent
T4055	19116-19127	NNS	denotes	pathologies
T4058	19128-19132	VBD	denotes	were
T4057	19133-19146	VBN	denotes	characterized
T4060	19147-19149	IN	denotes	in
T4061	19150-19153	DT	denotes	the
T4063	19154-19157	NN	denotes	Crx
T4064	19157-19158	SYM	denotes	-
T4065	19158-19159	HYPH	denotes	/
T4066	19159-19160	SYM	denotes	-
T4062	19161-19167	NN	denotes	retina
T4067	19167-19169	:	denotes	:
T4068	19169-19170	-LRB-	denotes	(
T4069	19170-19171	LS	denotes	1
T4071	19171-19172	-RRB-	denotes	)
T4072	19173-19175	DT	denotes	An
T4074	19176-19184	JJ	denotes	absolute
T4073	19185-19190	NN	denotes	block
T4075	19191-19193	IN	denotes	in
T4076	19194-19199	JJ	denotes	outer
T4077	19200-19207	NN	denotes	segment
T4078	19208-19221	NN	denotes	morphogenesis
T4079	19222-19225	VBD	denotes	was
T4070	19226-19231	VBN	denotes	noted
T4080	19231-19233	,	denotes	,
T4081	19233-19237	IN	denotes	with
T4082	19238-19241	DT	denotes	the
T4083	19242-19247	NN	denotes	block
T4084	19248-19256	VBG	denotes	occuring
T4085	19257-19259	IN	denotes	at
T4086	19260-19263	DT	denotes	the
T4088	19264-19274	NN	denotes	elongation
T4087	19275-19280	NN	denotes	stage
T4089	19281-19283	IN	denotes	of
T4090	19284-19289	JJ	denotes	outer
T4091	19290-19297	NN	denotes	segment
T4092	19298-19307	NN	denotes	formation
T4093	19307-19308	:	denotes	;
T4094	19309-19310	-LRB-	denotes	(
T4095	19310-19311	LS	denotes	2
T4096	19311-19312	-RRB-	denotes	)
T4097	19313-19316	NN	denotes	Crx
T4099	19316-19317	SYM	denotes	-
T4100	19317-19318	HYPH	denotes	/
T4101	19318-19319	SYM	denotes	-
T4098	19320-19334	NNS	denotes	photoreceptors
T4059	19335-19344	VBD	denotes	exhibited
T4102	19345-19346	DT	denotes	a
T4104	19347-19353	JJ	denotes	severe
T4103	19354-19366	NN	denotes	perturbation
T4105	19367-19369	IN	denotes	in
T4106	19370-19377	NN	denotes	synapse
T4107	19378-19387	NN	denotes	formation
T4108	19387-19388	.	denotes	.
T4109	19388-19475	sentence	denotes	This represents the first report of a synaptogenesis defect in an animal model of LCA.
T4110	19389-19393	DT	denotes	This
T4111	19394-19404	VBZ	denotes	represents
T4112	19405-19408	DT	denotes	the
T4114	19409-19414	JJ	denotes	first
T4113	19415-19421	NN	denotes	report
T4115	19422-19424	IN	denotes	of
T4116	19425-19426	DT	denotes	a
T4118	19427-19441	NN	denotes	synaptogenesis
T4117	19442-19448	NN	denotes	defect
T4119	19449-19451	IN	denotes	in
T4120	19452-19454	DT	denotes	an
T4122	19455-19461	NN	denotes	animal
T4121	19462-19467	NN	denotes	model
T4123	19468-19470	IN	denotes	of
T4124	19471-19474	NN	denotes	LCA
T4125	19474-19475	.	denotes	.
T4696	19477-19480	NN	denotes	Crx
T4698	19480-19481	SYM	denotes	-
T4699	19481-19482	HYPH	denotes	/
T4700	19482-19483	SYM	denotes	-
T4697	19484-19498	NNS	denotes	photoreceptors
T4702	19499-19502	MD	denotes	can
T4703	19502-19505	RB	denotes	not
T4701	19506-19514	VB	denotes	complete
T4704	19515-19520	JJ	denotes	outer
T4705	19521-19528	NN	denotes	segment
T4706	19529-19542	NN	denotes	morphogenesis
T4707	19542-19655	sentence	denotes	Mutations in Crx represent one of a collection of gene mutations that lead to an outer segment formation defect.
T4708	19543-19552	NNS	denotes	Mutations
T4710	19553-19555	IN	denotes	in
T4711	19556-19559	NN	denotes	Crx
T4709	19560-19569	VBP	denotes	represent
T4712	19570-19573	CD	denotes	one
T4713	19574-19576	IN	denotes	of
T4714	19577-19578	DT	denotes	a
T4715	19579-19589	NN	denotes	collection
T4716	19590-19592	IN	denotes	of
T4717	19593-19597	NN	denotes	gene
T4718	19598-19607	NNS	denotes	mutations
T4719	19608-19612	WDT	denotes	that
T4720	19613-19617	VBP	denotes	lead
T4721	19618-19620	IN	denotes	to
T4722	19621-19623	DT	denotes	an
T4724	19624-19629	JJ	denotes	outer
T4725	19630-19637	NN	denotes	segment
T4726	19638-19647	NN	denotes	formation
T4723	19648-19654	NN	denotes	defect
T4727	19654-19655	.	denotes	.
T4728	19655-19780	sentence	denotes	Homozygous null mutations in the peripherin/RDS gene [36] or in rhodopsin [29] lead to a failure of outer segment formation.
T4729	19656-19666	JJ	denotes	Homozygous
T4731	19667-19671	JJ	denotes	null
T4730	19672-19681	NNS	denotes	mutations
T4733	19682-19684	IN	denotes	in
T4734	19685-19688	DT	denotes	the
T4736	19689-19699	NN	denotes	peripherin
T4738	19699-19700	HYPH	denotes	/
T4737	19700-19703	NN	denotes	RDS
T4735	19704-19708	NN	denotes	gene
T4739	19709-19710	-LRB-	denotes	[
T4740	19710-19712	CD	denotes	36
T4741	19712-19713	-RRB-	denotes	]
T4742	19714-19716	CC	denotes	or
T4743	19717-19719	IN	denotes	in
T4744	19720-19729	NN	denotes	rhodopsin
T4745	19730-19731	-LRB-	denotes	[
T4746	19731-19733	CD	denotes	29
T4747	19733-19734	-RRB-	denotes	]
T4732	19735-19739	VBP	denotes	lead
T4748	19740-19742	IN	denotes	to
T4749	19743-19744	DT	denotes	a
T4750	19745-19752	NN	denotes	failure
T4751	19753-19755	IN	denotes	of
T4752	19756-19761	JJ	denotes	outer
T4753	19762-19769	NN	denotes	segment
T4754	19770-19779	NN	denotes	formation
T4755	19779-19780	.	denotes	.
T4756	19780-19880	sentence	denotes	The deficits in peripherin-/- and Crx-/- photoreceptor morphogenesis were found to be very similar.
T4757	19781-19784	DT	denotes	The
T4758	19785-19793	NNS	denotes	deficits
T4760	19794-19796	IN	denotes	in
T4761	19797-19807	NN	denotes	peripherin
T4763	19807-19808	SYM	denotes	-
T4764	19808-19809	HYPH	denotes	/
T4765	19809-19810	SYM	denotes	-
T4766	19811-19814	CC	denotes	and
T4767	19815-19818	NN	denotes	Crx
T4768	19818-19819	SYM	denotes	-
T4769	19819-19820	HYPH	denotes	/
T4770	19820-19821	SYM	denotes	-
T4771	19822-19835	NN	denotes	photoreceptor
T4762	19836-19849	NN	denotes	morphogenesis
T4772	19850-19854	VBD	denotes	were
T4759	19855-19860	VBN	denotes	found
T4773	19861-19863	TO	denotes	to
T4774	19864-19866	VB	denotes	be
T4775	19867-19871	RB	denotes	very
T4776	19872-19879	JJ	denotes	similar
T4777	19879-19880	.	denotes	.
T4778	19880-20016	sentence	denotes	Vesicular structures in Crx-/- photoreceptors were observed that were similar to those previously noted in the rds/peripherin-/- mouse.
T4779	19881-19890	JJ	denotes	Vesicular
T4780	19891-19901	NNS	denotes	structures
T4782	19902-19904	IN	denotes	in
T4783	19905-19908	NN	denotes	Crx
T4785	19908-19909	SYM	denotes	-
T4786	19909-19910	HYPH	denotes	/
T4787	19910-19911	SYM	denotes	-
T4784	19912-19926	NNS	denotes	photoreceptors
T4788	19927-19931	VBD	denotes	were
T4781	19932-19940	VBN	denotes	observed
T4789	19941-19945	WDT	denotes	that
T4790	19946-19950	VBD	denotes	were
T4791	19951-19958	JJ	denotes	similar
T4792	19959-19961	IN	denotes	to
T4793	19962-19967	DT	denotes	those
T4794	19968-19978	RB	denotes	previously
T4795	19979-19984	VBN	denotes	noted
T4796	19985-19987	IN	denotes	in
T4797	19988-19991	DT	denotes	the
T4799	19992-19995	NN	denotes	rds
T4801	19995-19996	HYPH	denotes	/
T4800	19996-20006	NN	denotes	peripherin
T4802	20006-20007	SYM	denotes	-
T4803	20007-20008	HYPH	denotes	/
T4804	20008-20009	SYM	denotes	-
T4798	20010-20015	NN	denotes	mouse
T4805	20015-20016	.	denotes	.
T4806	20016-20281	sentence	denotes	It was initially proposed that these vesicles were due to the breakdown of outer segment membranes that were not properly recruited to the outer segments in the absence of peripherin, or were from the result of the breakdown of the microvilli of Müller cells [30].
T4807	20017-20019	PRP	denotes	It
T4809	20020-20023	VBD	denotes	was
T4810	20024-20033	RB	denotes	initially
T4808	20034-20042	VBN	denotes	proposed
T4811	20043-20047	IN	denotes	that
T4813	20048-20053	DT	denotes	these
T4814	20054-20062	NNS	denotes	vesicles
T4812	20063-20067	VBD	denotes	were
T4815	20068-20071	IN	denotes	due
T4816	20072-20074	IN	denotes	to
T4817	20075-20078	DT	denotes	the
T4818	20079-20088	NN	denotes	breakdown
T4819	20089-20091	IN	denotes	of
T4820	20092-20097	JJ	denotes	outer
T4821	20098-20105	NN	denotes	segment
T4822	20106-20115	NNS	denotes	membranes
T4823	20116-20120	WDT	denotes	that
T4825	20121-20125	VBD	denotes	were
T4826	20126-20129	RB	denotes	not
T4827	20130-20138	RB	denotes	properly
T4824	20139-20148	VBN	denotes	recruited
T4828	20149-20151	IN	denotes	to
T4829	20152-20155	DT	denotes	the
T4831	20156-20161	JJ	denotes	outer
T4830	20162-20170	NNS	denotes	segments
T4832	20171-20173	IN	denotes	in
T4833	20174-20177	DT	denotes	the
T4834	20178-20185	NN	denotes	absence
T4835	20186-20188	IN	denotes	of
T4836	20189-20199	NN	denotes	peripherin
T4837	20199-20201	,	denotes	,
T4838	20201-20203	CC	denotes	or
T4839	20204-20208	VBD	denotes	were
T4840	20209-20213	IN	denotes	from
T4841	20214-20217	DT	denotes	the
T4842	20218-20224	NN	denotes	result
T4843	20225-20227	IN	denotes	of
T4844	20228-20231	DT	denotes	the
T4845	20232-20241	NN	denotes	breakdown
T4846	20242-20244	IN	denotes	of
T4847	20245-20248	DT	denotes	the
T4848	20249-20259	NNS	denotes	microvilli
T4849	20260-20262	IN	denotes	of
T4850	20263-20269	NN	denotes	Müller
T4851	20270-20275	NNS	denotes	cells
T4852	20276-20277	-LRB-	denotes	[
T4853	20277-20279	CD	denotes	30
T4854	20279-20280	-RRB-	denotes	]
T4855	20280-20281	.	denotes	.
T4856	20281-20501	sentence	denotes	Strong support in favor of the former explanation was provided by Nir and colleagues who demonstrated the presence of rhodopsin protein in these vesicles using immunoelectron microscopy against a rhodopsin epitope [37].
T4857	20282-20288	JJ	denotes	Strong
T4858	20289-20296	NN	denotes	support
T4860	20297-20299	IN	denotes	in
T4861	20300-20305	NN	denotes	favor
T4862	20306-20308	IN	denotes	of
T4863	20309-20312	DT	denotes	the
T4865	20313-20319	JJ	denotes	former
T4864	20320-20331	NN	denotes	explanation
T4866	20332-20335	VBD	denotes	was
T4859	20336-20344	VBN	denotes	provided
T4867	20345-20347	IN	denotes	by
T4868	20348-20351	NN	denotes	Nir
T4869	20352-20355	CC	denotes	and
T4870	20356-20366	NNS	denotes	colleagues
T4871	20367-20370	WP	denotes	who
T4872	20371-20383	VBD	denotes	demonstrated
T4873	20384-20387	DT	denotes	the
T4874	20388-20396	NN	denotes	presence
T4875	20397-20399	IN	denotes	of
T4876	20400-20409	NN	denotes	rhodopsin
T4877	20410-20417	NN	denotes	protein
T4878	20418-20420	IN	denotes	in
T4879	20421-20426	DT	denotes	these
T4880	20427-20435	NNS	denotes	vesicles
T4881	20436-20441	VBG	denotes	using
T4882	20442-20456	NN	denotes	immunoelectron
T4883	20457-20467	NN	denotes	microscopy
T4884	20468-20475	IN	denotes	against
T4885	20476-20477	DT	denotes	a
T4887	20478-20487	NN	denotes	rhodopsin
T4886	20488-20495	NN	denotes	epitope
T4888	20496-20497	-LRB-	denotes	[
T4889	20497-20499	CD	denotes	37
T4890	20499-20500	-RRB-	denotes	]
T4891	20500-20501	.	denotes	.
T4892	20501-20588	sentence	denotes	Further, as shown here, the vesicles appear to bud from the inner segments themselves.
T4893	20502-20509	RB	denotes	Further
T4895	20509-20511	,	denotes	,
T4896	20511-20513	IN	denotes	as
T4897	20514-20519	VBN	denotes	shown
T4898	20520-20524	RB	denotes	here
T4899	20524-20526	,	denotes	,
T4900	20526-20529	DT	denotes	the
T4901	20530-20538	NNS	denotes	vesicles
T4894	20539-20545	VBP	denotes	appear
T4902	20546-20548	TO	denotes	to
T4903	20549-20552	VB	denotes	bud
T4904	20553-20557	IN	denotes	from
T4905	20558-20561	DT	denotes	the
T4907	20562-20567	JJ	denotes	inner
T4906	20568-20576	NNS	denotes	segments
T4908	20577-20587	PRP	denotes	themselves
T4909	20587-20588	.	denotes	.
T4910	20588-20766	sentence	denotes	In developing photoreceptors, an extraordinary growth process occurs whereby the outer segment is generated from the nascent connecting cilium (see [38] and references therein).
T4911	20589-20591	IN	denotes	In
T4913	20592-20602	VBG	denotes	developing
T4914	20603-20617	NNS	denotes	photoreceptors
T4915	20617-20619	,	denotes	,
T4916	20619-20621	DT	denotes	an
T4918	20622-20635	JJ	denotes	extraordinary
T4919	20636-20642	NN	denotes	growth
T4917	20643-20650	NN	denotes	process
T4912	20651-20657	VBZ	denotes	occurs
T4920	20658-20665	WRB	denotes	whereby
T4922	20666-20669	DT	denotes	the
T4924	20670-20675	JJ	denotes	outer
T4923	20676-20683	NN	denotes	segment
T4925	20684-20686	VBZ	denotes	is
T4921	20687-20696	VBN	denotes	generated
T4926	20697-20701	IN	denotes	from
T4927	20702-20705	DT	denotes	the
T4929	20706-20713	JJ	denotes	nascent
T4930	20714-20724	VBG	denotes	connecting
T4928	20725-20731	NN	denotes	cilium
T4931	20732-20733	-LRB-	denotes	(
T4932	20733-20736	VB	denotes	see
T4933	20737-20738	-LRB-	denotes	[
T4934	20738-20740	CD	denotes	38
T4935	20740-20741	-RRB-	denotes	]
T4936	20742-20745	CC	denotes	and
T4937	20746-20756	NNS	denotes	references
T4938	20757-20764	RB	denotes	therein
T4939	20764-20765	-RRB-	denotes	)
T4940	20765-20766	.	denotes	.
T4941	20766-20970	sentence	denotes	Peripherin/RDS and ROM-1 proteins (localized in disc rims) and the opsin proteins (localized throughout the discs) have important roles in the structural integrity of mature outer segments (see [39,29]).
T4942	20767-20777	NN	denotes	Peripherin
T4944	20777-20778	HYPH	denotes	/
T4943	20778-20781	NN	denotes	RDS
T4946	20782-20785	CC	denotes	and
T4947	20786-20789	NN	denotes	ROM
T4948	20789-20790	HYPH	denotes	-
T4949	20790-20791	CD	denotes	1
T4945	20792-20800	NN	denotes	proteins
T4951	20801-20802	-LRB-	denotes	(
T4952	20802-20811	VBN	denotes	localized
T4953	20812-20814	IN	denotes	in
T4954	20815-20819	NN	denotes	disc
T4955	20820-20824	NNS	denotes	rims
T4956	20824-20825	-RRB-	denotes	)
T4957	20826-20829	CC	denotes	and
T4958	20830-20833	DT	denotes	the
T4960	20834-20839	NN	denotes	opsin
T4959	20840-20848	NN	denotes	proteins
T4961	20849-20850	-LRB-	denotes	(
T4962	20850-20859	VBN	denotes	localized
T4963	20860-20870	IN	denotes	throughout
T4964	20871-20874	DT	denotes	the
T4965	20875-20880	NNS	denotes	discs
T4966	20880-20881	-RRB-	denotes	)
T4950	20882-20886	VBP	denotes	have
T4967	20887-20896	JJ	denotes	important
T4968	20897-20902	NNS	denotes	roles
T4969	20903-20905	IN	denotes	in
T4970	20906-20909	DT	denotes	the
T4972	20910-20920	JJ	denotes	structural
T4971	20921-20930	NN	denotes	integrity
T4973	20931-20933	IN	denotes	of
T4974	20934-20940	JJ	denotes	mature
T4976	20941-20946	JJ	denotes	outer
T4975	20947-20955	NNS	denotes	segments
T4977	20956-20957	-LRB-	denotes	(
T4978	20957-20960	VB	denotes	see
T4979	20961-20962	-LRB-	denotes	[
T4980	20962-20964	CD	denotes	39
T4982	20964-20965	,	denotes	,
T4981	20965-20967	CD	denotes	29
T4983	20967-20968	-RRB-	denotes	]
T4984	20968-20969	-RRB-	denotes	)
T4985	20969-20970	.	denotes	.
T4986	20970-21043	sentence	denotes	ROM-1-/- mice produce disorganized outer segments with large disks [40].
T4987	20971-20974	NN	denotes	ROM
T4989	20974-20975	HYPH	denotes	-
T4990	20975-20976	CD	denotes	1
T4991	20976-20977	SYM	denotes	-
T4992	20977-20978	HYPH	denotes	/
T4993	20978-20979	SYM	denotes	-
T4988	20980-20984	NNS	denotes	mice
T4994	20985-20992	VBP	denotes	produce
T4995	20993-21005	VBN	denotes	disorganized
T4997	21006-21011	JJ	denotes	outer
T4996	21012-21020	NNS	denotes	segments
T4998	21021-21025	IN	denotes	with
T4999	21026-21031	JJ	denotes	large
T5000	21032-21037	NNS	denotes	disks
T5001	21038-21039	-LRB-	denotes	[
T5002	21039-21041	CD	denotes	40
T5003	21041-21042	-RRB-	denotes	]
T5004	21042-21043	.	denotes	.
T5005	21043-21247	sentence	denotes	Crx, by virtue of being a transcription factor, presumably controls genes that are responsible for the building and perhaps maintenance of the outer segment structure, including rhodopsin and peripherin.
T5006	21044-21047	NN	denotes	Crx
T5008	21047-21049	,	denotes	,
T5009	21049-21051	IN	denotes	by
T5010	21052-21058	NN	denotes	virtue
T5011	21059-21061	IN	denotes	of
T5012	21062-21067	VBG	denotes	being
T5013	21068-21069	DT	denotes	a
T5015	21070-21083	NN	denotes	transcription
T5014	21084-21090	NN	denotes	factor
T5016	21090-21092	,	denotes	,
T5017	21092-21102	RB	denotes	presumably
T5007	21103-21111	VBZ	denotes	controls
T5018	21112-21117	NNS	denotes	genes
T5019	21118-21122	WDT	denotes	that
T5020	21123-21126	VBP	denotes	are
T5021	21127-21138	JJ	denotes	responsible
T5022	21139-21142	IN	denotes	for
T5023	21143-21146	DT	denotes	the
T5024	21147-21155	NN	denotes	building
T5025	21156-21159	CC	denotes	and
T5026	21160-21167	RB	denotes	perhaps
T5027	21168-21179	NN	denotes	maintenance
T5028	21180-21182	IN	denotes	of
T5029	21183-21186	DT	denotes	the
T5031	21187-21192	JJ	denotes	outer
T5032	21193-21200	NN	denotes	segment
T5030	21201-21210	NN	denotes	structure
T5033	21210-21212	,	denotes	,
T5034	21212-21221	VBG	denotes	including
T5035	21222-21231	NN	denotes	rhodopsin
T5036	21232-21235	CC	denotes	and
T5037	21236-21246	NN	denotes	peripherin
T5038	21246-21247	.	denotes	.
T5039	21247-21443	sentence	denotes	Using northern blots [34], microarrays [10], and serial analysis of gene expression (SAGE) [35], we have defined a large number of genes that are altered in their expression level in Crx-/- mice.
T5040	21248-21253	VBG	denotes	Using
T5042	21254-21262	NNP	denotes	northern
T5043	21263-21268	NNS	denotes	blots
T5044	21269-21270	-LRB-	denotes	[
T5045	21270-21272	CD	denotes	34
T5046	21272-21273	-RRB-	denotes	]
T5047	21273-21275	,	denotes	,
T5048	21275-21286	NNS	denotes	microarrays
T5049	21287-21288	-LRB-	denotes	[
T5050	21288-21290	CD	denotes	10
T5051	21290-21291	-RRB-	denotes	]
T5052	21291-21293	,	denotes	,
T5053	21293-21296	CC	denotes	and
T5054	21297-21303	JJ	denotes	serial
T5055	21304-21312	NN	denotes	analysis
T5056	21313-21315	IN	denotes	of
T5057	21316-21320	NN	denotes	gene
T5058	21321-21331	NN	denotes	expression
T5059	21332-21333	-LRB-	denotes	(
T5060	21333-21337	NN	denotes	SAGE
T5061	21337-21338	-RRB-	denotes	)
T5062	21339-21340	-LRB-	denotes	[
T5063	21340-21342	CD	denotes	35
T5064	21342-21343	-RRB-	denotes	]
T5065	21343-21345	,	denotes	,
T5066	21345-21347	PRP	denotes	we
T5067	21348-21352	VBP	denotes	have
T5041	21353-21360	VBN	denotes	defined
T5068	21361-21362	DT	denotes	a
T5070	21363-21368	JJ	denotes	large
T5069	21369-21375	NN	denotes	number
T5071	21376-21378	IN	denotes	of
T5072	21379-21384	NNS	denotes	genes
T5073	21385-21389	WDT	denotes	that
T5075	21390-21393	VBP	denotes	are
T5074	21394-21401	VBN	denotes	altered
T5076	21402-21404	IN	denotes	in
T5077	21405-21410	PRP$	denotes	their
T5079	21411-21421	NN	denotes	expression
T5078	21422-21427	NN	denotes	level
T5080	21428-21430	IN	denotes	in
T5081	21431-21434	NN	denotes	Crx
T5083	21434-21435	SYM	denotes	-
T5084	21435-21436	HYPH	denotes	/
T5085	21436-21437	SYM	denotes	-
T5082	21438-21442	NNS	denotes	mice
T5086	21442-21443	.	denotes	.
T5087	21443-21575	sentence	denotes	We found that rhodopsin expression was severely diminished in Crx-/- animals, and peripherin mRNA was reduced by approximately 30%.
T5088	21444-21446	PRP	denotes	We
T5089	21447-21452	VBD	denotes	found
T5090	21453-21457	IN	denotes	that
T5092	21458-21467	NN	denotes	rhodopsin
T5093	21468-21478	NN	denotes	expression
T5094	21479-21482	VBD	denotes	was
T5095	21483-21491	RB	denotes	severely
T5091	21492-21502	VBN	denotes	diminished
T5096	21503-21505	IN	denotes	in
T5097	21506-21509	NN	denotes	Crx
T5099	21509-21510	SYM	denotes	-
T5100	21510-21511	HYPH	denotes	/
T5101	21511-21512	SYM	denotes	-
T5098	21513-21520	NNS	denotes	animals
T5102	21520-21522	,	denotes	,
T5103	21522-21525	CC	denotes	and
T5104	21526-21536	NN	denotes	peripherin
T5105	21537-21541	NN	denotes	mRNA
T5107	21542-21545	VBD	denotes	was
T5106	21546-21553	VBN	denotes	reduced
T5108	21554-21556	IN	denotes	by
T5109	21557-21570	RB	denotes	approximately
T5110	21571-21573	CD	denotes	30
T5111	21573-21574	NN	denotes	%
T5112	21574-21575	.	denotes	.
T5113	21575-21744	sentence	denotes	Transgenic mice with variable levels of expression of wild type rhodopsin exhibit rod degeneration [41], indicating the importance of the level of rhodopsin expression.
T5114	21576-21586	JJ	denotes	Transgenic
T5115	21587-21591	NNS	denotes	mice
T5117	21592-21596	IN	denotes	with
T5118	21597-21605	JJ	denotes	variable
T5119	21606-21612	NNS	denotes	levels
T5120	21613-21615	IN	denotes	of
T5121	21616-21626	NN	denotes	expression
T5122	21627-21629	IN	denotes	of
T5123	21630-21634	JJ	denotes	wild
T5124	21635-21639	NN	denotes	type
T5125	21640-21649	NN	denotes	rhodopsin
T5116	21650-21657	VBP	denotes	exhibit
T5126	21658-21661	NN	denotes	rod
T5127	21662-21674	NN	denotes	degeneration
T5128	21675-21676	-LRB-	denotes	[
T5129	21676-21678	CD	denotes	41
T5130	21678-21679	-RRB-	denotes	]
T5131	21679-21681	,	denotes	,
T5132	21681-21691	VBG	denotes	indicating
T5133	21692-21695	DT	denotes	the
T5134	21696-21706	NN	denotes	importance
T5135	21707-21709	IN	denotes	of
T5136	21710-21713	DT	denotes	the
T5137	21714-21719	NN	denotes	level
T5138	21720-21722	IN	denotes	of
T5139	21723-21732	NN	denotes	rhodopsin
T5140	21733-21743	NN	denotes	expression
T5141	21743-21744	.	denotes	.
T5142	21744-21854	sentence	denotes	In addition, the timing of rhodopsin expression may be very important, as indicated by studies in Drosophila.
T5143	21745-21747	IN	denotes	In
T5145	21748-21756	NN	denotes	addition
T5146	21756-21758	,	denotes	,
T5147	21758-21761	DT	denotes	the
T5148	21762-21768	NN	denotes	timing
T5149	21769-21771	IN	denotes	of
T5150	21772-21781	NN	denotes	rhodopsin
T5151	21782-21792	NN	denotes	expression
T5152	21793-21796	MD	denotes	may
T5144	21797-21799	VB	denotes	be
T5153	21800-21804	RB	denotes	very
T5154	21805-21814	JJ	denotes	important
T5155	21814-21816	,	denotes	,
T5156	21816-21818	IN	denotes	as
T5157	21819-21828	VBN	denotes	indicated
T5158	21829-21831	IN	denotes	by
T5159	21832-21839	NNS	denotes	studies
T5160	21840-21842	IN	denotes	in
T5161	21843-21853	NNP	denotes	Drosophila
T5162	21853-21854	.	denotes	.
T5163	21854-21925	sentence	denotes	In Drosophila, rhodopsin (ninaE) is expressed in photoreceptors R1–R6.
T5164	21855-21857	IN	denotes	In
T5166	21858-21868	NNP	denotes	Drosophila
T5167	21868-21870	,	denotes	,
T5168	21870-21879	NN	denotes	rhodopsin
T5169	21880-21881	-LRB-	denotes	(
T5170	21881-21886	NN	denotes	ninaE
T5171	21886-21887	-RRB-	denotes	)
T5172	21888-21890	VBZ	denotes	is
T5165	21891-21900	VBN	denotes	expressed
T5173	21901-21903	IN	denotes	in
T5174	21904-21918	NNS	denotes	photoreceptors
T5175	21919-21921	NN	denotes	R1
T5176	21921-21922	SYM	denotes	–
T5177	21922-21924	NN	denotes	R6
T5178	21924-21925	.	denotes	.
T5179	21925-22119	sentence	denotes	In ninaE null mutants, the rhabdomere, a structure analogous to vertebrate outer segments, fails to develop in R1–R6 photoreceptors [42], reminiscent of the situation in rhodopsin-/- mice [29].
T5180	21926-21928	IN	denotes	In
T5182	21929-21934	NN	denotes	ninaE
T5183	21935-21939	JJ	denotes	null
T5184	21940-21947	NNS	denotes	mutants
T5185	21947-21949	,	denotes	,
T5186	21949-21952	DT	denotes	the
T5187	21953-21963	NN	denotes	rhabdomere
T5188	21963-21965	,	denotes	,
T5189	21965-21966	DT	denotes	a
T5190	21967-21976	NN	denotes	structure
T5191	21977-21986	JJ	denotes	analogous
T5192	21987-21989	IN	denotes	to
T5193	21990-22000	NN	denotes	vertebrate
T5195	22001-22006	JJ	denotes	outer
T5194	22007-22015	NNS	denotes	segments
T5196	22015-22017	,	denotes	,
T5181	22017-22022	VBZ	denotes	fails
T5197	22023-22025	TO	denotes	to
T5198	22026-22033	VB	denotes	develop
T5199	22034-22036	IN	denotes	in
T5200	22037-22039	NN	denotes	R1
T5202	22039-22040	SYM	denotes	–
T5203	22040-22042	NN	denotes	R6
T5201	22043-22057	NNS	denotes	photoreceptors
T5204	22058-22059	-LRB-	denotes	[
T5205	22059-22061	CD	denotes	42
T5206	22061-22062	-RRB-	denotes	]
T5207	22062-22064	,	denotes	,
T5208	22064-22075	JJ	denotes	reminiscent
T5209	22076-22078	IN	denotes	of
T5210	22079-22082	DT	denotes	the
T5211	22083-22092	NN	denotes	situation
T5212	22093-22095	IN	denotes	in
T5213	22096-22105	NN	denotes	rhodopsin
T5215	22105-22106	SYM	denotes	-
T5216	22106-22107	HYPH	denotes	/
T5217	22107-22108	SYM	denotes	-
T5214	22109-22113	NNS	denotes	mice
T5218	22114-22115	-LRB-	denotes	[
T5219	22115-22117	CD	denotes	29
T5220	22117-22118	-RRB-	denotes	]
T5221	22118-22119	.	denotes	.
T5222	22119-22257	sentence	denotes	An intriguing experiment by Kumar et al. [43] demonstrated a temporal requirement for rhodopsin expression during rhabdomere development.
T5223	22120-22122	DT	denotes	An
T5225	22123-22133	JJ	denotes	intriguing
T5224	22134-22144	NN	denotes	experiment
T5227	22145-22147	IN	denotes	by
T5228	22148-22153	NNP	denotes	Kumar
T5229	22154-22156	FW	denotes	et
T5230	22157-22160	FW	denotes	al.
T5231	22161-22162	-LRB-	denotes	[
T5232	22162-22164	CD	denotes	43
T5233	22164-22165	-RRB-	denotes	]
T5226	22166-22178	VBD	denotes	demonstrated
T5234	22179-22180	DT	denotes	a
T5236	22181-22189	JJ	denotes	temporal
T5235	22190-22201	NN	denotes	requirement
T5237	22202-22205	IN	denotes	for
T5238	22206-22215	NN	denotes	rhodopsin
T5239	22216-22226	NN	denotes	expression
T5240	22227-22233	IN	denotes	during
T5241	22234-22244	NN	denotes	rhabdomere
T5242	22245-22256	NN	denotes	development
T5243	22256-22257	.	denotes	.
T5244	22257-22403	sentence	denotes	In ninaE null flies, a ninaE transgene under the control of a heat shock promoter was subjected to various temperature shifts during development.
T5245	22258-22260	IN	denotes	In
T5247	22261-22266	NN	denotes	ninaE
T5248	22267-22271	JJ	denotes	null
T5249	22272-22277	NNS	denotes	flies
T5250	22277-22279	,	denotes	,
T5251	22279-22280	DT	denotes	a
T5253	22281-22286	NN	denotes	ninaE
T5252	22287-22296	NN	denotes	transgene
T5254	22297-22302	IN	denotes	under
T5255	22303-22306	DT	denotes	the
T5256	22307-22314	NN	denotes	control
T5257	22315-22317	IN	denotes	of
T5258	22318-22319	DT	denotes	a
T5260	22320-22324	NN	denotes	heat
T5261	22325-22330	NN	denotes	shock
T5259	22331-22339	NN	denotes	promoter
T5262	22340-22343	VBD	denotes	was
T5246	22344-22353	VBN	denotes	subjected
T5263	22354-22356	IN	denotes	to
T5264	22357-22364	JJ	denotes	various
T5266	22365-22376	NN	denotes	temperature
T5265	22377-22383	NNS	denotes	shifts
T5267	22384-22390	IN	denotes	during
T5268	22391-22402	NN	denotes	development
T5269	22402-22403	.	denotes	.
T5270	22403-22581	sentence	denotes	Heat shock during the normal time of rhodopsin onset resulted in substantial and long-lasting rescue of photoreceptor structure and transient rescue of photoreceptor physiology.
T5271	22404-22408	NN	denotes	Heat
T5272	22409-22414	NN	denotes	shock
T5274	22415-22421	IN	denotes	during
T5275	22422-22425	DT	denotes	the
T5277	22426-22432	JJ	denotes	normal
T5276	22433-22437	NN	denotes	time
T5278	22438-22440	IN	denotes	of
T5279	22441-22450	NN	denotes	rhodopsin
T5280	22451-22456	NN	denotes	onset
T5273	22457-22465	VBD	denotes	resulted
T5281	22466-22468	IN	denotes	in
T5282	22469-22480	JJ	denotes	substantial
T5284	22481-22484	CC	denotes	and
T5285	22485-22489	RB	denotes	long
T5287	22489-22490	HYPH	denotes	-
T5286	22490-22497	VBG	denotes	lasting
T5283	22498-22504	NN	denotes	rescue
T5288	22505-22507	IN	denotes	of
T5289	22508-22521	NN	denotes	photoreceptor
T5290	22522-22531	NN	denotes	structure
T5291	22532-22535	CC	denotes	and
T5292	22536-22545	JJ	denotes	transient
T5293	22546-22552	NN	denotes	rescue
T5294	22553-22555	IN	denotes	of
T5295	22556-22569	NN	denotes	photoreceptor
T5296	22570-22580	NN	denotes	physiology
T5297	22580-22581	.	denotes	.
T5298	22581-22799	sentence	denotes	However, expression shortly before or after this critical period failed to rescue, suggesting that rhodopsin expression during a discrete window of time in development is essential for proper rhabdomere morphogenesis.
T5299	22582-22589	RB	denotes	However
T5301	22589-22591	,	denotes	,
T5302	22591-22601	NN	denotes	expression
T5303	22602-22609	RB	denotes	shortly
T5304	22610-22616	IN	denotes	before
T5305	22617-22619	CC	denotes	or
T5306	22620-22625	IN	denotes	after
T5307	22626-22630	DT	denotes	this
T5309	22631-22639	JJ	denotes	critical
T5308	22640-22646	NN	denotes	period
T5300	22647-22653	VBD	denotes	failed
T5310	22654-22656	TO	denotes	to
T5311	22657-22663	VB	denotes	rescue
T5312	22663-22665	,	denotes	,
T5313	22665-22675	VBG	denotes	suggesting
T5314	22676-22680	IN	denotes	that
T5316	22681-22690	NN	denotes	rhodopsin
T5317	22691-22701	NN	denotes	expression
T5318	22702-22708	IN	denotes	during
T5319	22709-22710	DT	denotes	a
T5321	22711-22719	JJ	denotes	discrete
T5320	22720-22726	NN	denotes	window
T5322	22727-22729	IN	denotes	of
T5323	22730-22734	NN	denotes	time
T5324	22735-22737	IN	denotes	in
T5325	22738-22749	NN	denotes	development
T5315	22750-22752	VBZ	denotes	is
T5326	22753-22762	JJ	denotes	essential
T5327	22763-22766	IN	denotes	for
T5328	22767-22773	JJ	denotes	proper
T5330	22774-22784	JJ	denotes	rhabdomere
T5329	22785-22798	NN	denotes	morphogenesis
T5331	22798-22799	.	denotes	.
T5332	22799-22960	sentence	denotes	This result is consistent with observations in the rat wherein rhodopsin onset occurs with strict timing in the developmental history of most rods in vivo [44].
T5333	22800-22804	DT	denotes	This
T5334	22805-22811	NN	denotes	result
T5335	22812-22814	VBZ	denotes	is
T5336	22815-22825	JJ	denotes	consistent
T5337	22826-22830	IN	denotes	with
T5338	22831-22843	NNS	denotes	observations
T5339	22844-22846	IN	denotes	in
T5340	22847-22850	DT	denotes	the
T5341	22851-22854	NN	denotes	rat
T5342	22855-22862	IN	denotes	wherein
T5344	22863-22872	NN	denotes	rhodopsin
T5345	22873-22878	NN	denotes	onset
T5343	22879-22885	VBZ	denotes	occurs
T5346	22886-22890	IN	denotes	with
T5347	22891-22897	JJ	denotes	strict
T5348	22898-22904	NN	denotes	timing
T5349	22905-22907	IN	denotes	in
T5350	22908-22911	DT	denotes	the
T5352	22912-22925	JJ	denotes	developmental
T5351	22926-22933	NN	denotes	history
T5353	22934-22936	IN	denotes	of
T5354	22937-22941	JJS	denotes	most
T5355	22942-22946	NNS	denotes	rods
T5356	22947-22949	FW	denotes	in
T5357	22950-22954	FW	denotes	vivo
T5358	22955-22956	-LRB-	denotes	[
T5359	22956-22958	CD	denotes	44
T5360	22958-22959	-RRB-	denotes	]
T5361	22959-22960	.	denotes	.
T5362	22960-23161	sentence	denotes	Thus, through its regulation of rhodopsin levels, or perhaps through control of the kinetics of the up-regulation of rhodopsin beginning at about P6, Crx may be regulating outer segment morphogenesis.
T5363	22961-22965	RB	denotes	Thus
T5365	22965-22967	,	denotes	,
T5366	22967-22974	IN	denotes	through
T5367	22975-22978	PRP$	denotes	its
T5368	22979-22989	NN	denotes	regulation
T5369	22990-22992	IN	denotes	of
T5370	22993-23002	NN	denotes	rhodopsin
T5371	23003-23009	NNS	denotes	levels
T5372	23009-23011	,	denotes	,
T5373	23011-23013	CC	denotes	or
T5374	23014-23021	RB	denotes	perhaps
T5375	23022-23029	IN	denotes	through
T5376	23030-23037	NN	denotes	control
T5377	23038-23040	IN	denotes	of
T5378	23041-23044	DT	denotes	the
T5379	23045-23053	NN	denotes	kinetics
T5380	23054-23056	IN	denotes	of
T5381	23057-23060	DT	denotes	the
T5383	23061-23063	JJ	denotes	up
T5384	23063-23064	HYPH	denotes	-
T5382	23064-23074	NN	denotes	regulation
T5385	23075-23077	IN	denotes	of
T5386	23078-23087	NN	denotes	rhodopsin
T5387	23088-23097	VBG	denotes	beginning
T5388	23098-23100	IN	denotes	at
T5389	23101-23106	RB	denotes	about
T5390	23107-23109	NN	denotes	P6
T5391	23109-23111	,	denotes	,
T5392	23111-23114	NN	denotes	Crx
T5393	23115-23118	MD	denotes	may
T5394	23119-23121	VB	denotes	be
T5364	23122-23132	VBG	denotes	regulating
T5395	23133-23138	JJ	denotes	outer
T5396	23139-23146	NN	denotes	segment
T5397	23147-23160	NN	denotes	morphogenesis
T5398	23160-23161	.	denotes	.
T5399	23161-23212	sentence	denotes	The similarty of the two cases may extend further.
T5400	23162-23165	DT	denotes	The
T5401	23166-23175	NN	denotes	similarty
T5403	23176-23178	IN	denotes	of
T5404	23179-23182	DT	denotes	the
T5406	23183-23186	CD	denotes	two
T5405	23187-23192	NNS	denotes	cases
T5407	23193-23196	MD	denotes	may
T5402	23197-23203	VB	denotes	extend
T5408	23204-23211	RB	denotes	further
T5409	23211-23212	.	denotes	.
T5410	23212-23344	sentence	denotes	At present, the closest Crx relative in Drosophila is Otd, the founding member of the class of homeobox genes to which Crx belongs.
T5411	23213-23215	IN	denotes	At
T5413	23216-23223	JJ	denotes	present
T5414	23223-23225	,	denotes	,
T5415	23225-23228	DT	denotes	the
T5417	23229-23236	JJS	denotes	closest
T5416	23237-23240	NN	denotes	Crx
T5418	23241-23249	JJ	denotes	relative
T5419	23250-23252	IN	denotes	in
T5420	23253-23263	NNP	denotes	Drosophila
T5412	23264-23266	VBZ	denotes	is
T5421	23267-23270	NN	denotes	Otd
T5422	23270-23272	,	denotes	,
T5423	23272-23275	DT	denotes	the
T5425	23276-23284	JJ	denotes	founding
T5424	23285-23291	NN	denotes	member
T5426	23292-23294	IN	denotes	of
T5427	23295-23298	DT	denotes	the
T5428	23299-23304	NN	denotes	class
T5429	23305-23307	IN	denotes	of
T5430	23308-23316	NN	denotes	homeobox
T5431	23317-23322	NNS	denotes	genes
T5432	23323-23325	IN	denotes	to
T5434	23326-23331	WDT	denotes	which
T5435	23332-23335	NN	denotes	Crx
T5433	23336-23343	VBZ	denotes	belongs
T5436	23343-23344	.	denotes	.
T5437	23344-23464	sentence	denotes	Interestingly, in one hypomorphic allele of Drosophila otd, otduvi, photoreceptor morphogenesis is also disrupted [45].
T5438	23345-23358	RB	denotes	Interestingly
T5440	23358-23360	,	denotes	,
T5441	23360-23362	IN	denotes	in
T5442	23363-23366	CD	denotes	one
T5444	23367-23378	JJ	denotes	hypomorphic
T5443	23379-23385	NN	denotes	allele
T5445	23386-23388	IN	denotes	of
T5446	23389-23399	NNP	denotes	Drosophila
T5447	23400-23403	NN	denotes	otd
T5448	23403-23405	,	denotes	,
T5449	23405-23411	NN	denotes	otduvi
T5450	23411-23413	,	denotes	,
T5451	23413-23426	NN	denotes	photoreceptor
T5452	23427-23440	NN	denotes	morphogenesis
T5453	23441-23443	VBZ	denotes	is
T5454	23444-23448	RB	denotes	also
T5439	23449-23458	VBN	denotes	disrupted
T5455	23459-23460	-LRB-	denotes	[
T5456	23460-23462	CD	denotes	45
T5457	23462-23463	-RRB-	denotes	]
T5458	23463-23464	.	denotes	.
T5459	23464-23534	sentence	denotes	We found that there are many other genes that are dependent upon Crx.
T5460	23465-23467	PRP	denotes	We
T5461	23468-23473	VBD	denotes	found
T5462	23474-23478	IN	denotes	that
T5464	23479-23484	EX	denotes	there
T5463	23485-23488	VBP	denotes	are
T5465	23489-23493	JJ	denotes	many
T5467	23494-23499	JJ	denotes	other
T5466	23500-23505	NNS	denotes	genes
T5468	23506-23510	WDT	denotes	that
T5469	23511-23514	VBP	denotes	are
T5470	23515-23524	JJ	denotes	dependent
T5471	23525-23529	IN	denotes	upon
T5472	23530-23533	NN	denotes	Crx
T5473	23533-23534	.	denotes	.
T5474	23534-23727	sentence	denotes	Those that are expressed at a lower level in the Crx-/- retina, such as rhodopsin and peripherin, comprise many that are either enriched or specific to photoreceptors in their expression [35].
T5475	23535-23540	DT	denotes	Those
T5477	23541-23545	WDT	denotes	that
T5479	23546-23549	VBP	denotes	are
T5478	23550-23559	VBN	denotes	expressed
T5480	23560-23562	IN	denotes	at
T5481	23563-23564	DT	denotes	a
T5483	23565-23570	JJR	denotes	lower
T5482	23571-23576	NN	denotes	level
T5484	23577-23579	IN	denotes	in
T5485	23580-23583	DT	denotes	the
T5487	23584-23587	NN	denotes	Crx
T5488	23587-23588	SYM	denotes	-
T5489	23588-23589	HYPH	denotes	/
T5490	23589-23590	SYM	denotes	-
T5486	23591-23597	NN	denotes	retina
T5491	23597-23599	,	denotes	,
T5492	23599-23603	JJ	denotes	such
T5493	23604-23606	IN	denotes	as
T5494	23607-23616	NN	denotes	rhodopsin
T5495	23617-23620	CC	denotes	and
T5496	23621-23631	NN	denotes	peripherin
T5497	23631-23633	,	denotes	,
T5476	23633-23641	VBP	denotes	comprise
T5498	23642-23646	JJ	denotes	many
T5499	23647-23651	WDT	denotes	that
T5500	23652-23655	VBP	denotes	are
T5501	23656-23662	RB	denotes	either
T5502	23663-23671	VBN	denotes	enriched
T5503	23672-23674	CC	denotes	or
T5504	23675-23683	JJ	denotes	specific
T5505	23684-23686	IN	denotes	to
T5506	23687-23701	NNS	denotes	photoreceptors
T5507	23702-23704	IN	denotes	in
T5508	23705-23710	PRP$	denotes	their
T5509	23711-23721	NN	denotes	expression
T5510	23722-23723	-LRB-	denotes	[
T5511	23723-23725	CD	denotes	35
T5512	23725-23726	-RRB-	denotes	]
T5513	23726-23727	.	denotes	.
T5514	23727-23943	sentence	denotes	They include enzymes that are important in lipid metabolism, protein folding and transport, as well as in other processes that one might envision would be important in building a structure such as the outer segment.
T5515	23728-23732	PRP	denotes	They
T5516	23733-23740	VBP	denotes	include
T5517	23741-23748	NNS	denotes	enzymes
T5518	23749-23753	WDT	denotes	that
T5519	23754-23757	VBP	denotes	are
T5520	23758-23767	JJ	denotes	important
T5521	23768-23770	IN	denotes	in
T5522	23771-23776	NN	denotes	lipid
T5523	23777-23787	NN	denotes	metabolism
T5524	23787-23789	,	denotes	,
T5525	23789-23796	NN	denotes	protein
T5526	23797-23804	NN	denotes	folding
T5527	23805-23808	CC	denotes	and
T5528	23809-23818	NN	denotes	transport
T5529	23818-23820	,	denotes	,
T5530	23820-23822	RB	denotes	as
T5532	23823-23827	RB	denotes	well
T5531	23828-23830	IN	denotes	as
T5533	23831-23833	IN	denotes	in
T5534	23834-23839	JJ	denotes	other
T5535	23840-23849	NNS	denotes	processes
T5536	23850-23854	WDT	denotes	that
T5538	23855-23858	PRP	denotes	one
T5539	23859-23864	MD	denotes	might
T5537	23865-23873	VB	denotes	envision
T5540	23874-23879	MD	denotes	would
T5541	23880-23882	VB	denotes	be
T5542	23883-23892	JJ	denotes	important
T5543	23893-23895	IN	denotes	in
T5544	23896-23904	VBG	denotes	building
T5545	23905-23906	DT	denotes	a
T5546	23907-23916	NN	denotes	structure
T5547	23917-23921	JJ	denotes	such
T5548	23922-23924	IN	denotes	as
T5549	23925-23928	DT	denotes	the
T5551	23929-23934	JJ	denotes	outer
T5550	23935-23942	NN	denotes	segment
T5552	23942-23943	.	denotes	.
T5553	23943-24148	sentence	denotes	In situ hybridization using probes from this collection of genes has revealed that some of them have their RNA localized to the inner segment, a finding typical for proteins targeted to the outer segment.
T5554	23944-23946	FW	denotes	In
T5555	23947-23951	FW	denotes	situ
T5556	23952-23965	NN	denotes	hybridization
T5558	23966-23971	VBG	denotes	using
T5559	23972-23978	NNS	denotes	probes
T5560	23979-23983	IN	denotes	from
T5561	23984-23988	DT	denotes	this
T5562	23989-23999	NN	denotes	collection
T5563	24000-24002	IN	denotes	of
T5564	24003-24008	NNS	denotes	genes
T5565	24009-24012	VBZ	denotes	has
T5557	24013-24021	VBN	denotes	revealed
T5566	24022-24026	IN	denotes	that
T5568	24027-24031	DT	denotes	some
T5569	24032-24034	IN	denotes	of
T5570	24035-24039	PRP	denotes	them
T5567	24040-24044	VBP	denotes	have
T5571	24045-24050	PRP$	denotes	their
T5572	24051-24054	NN	denotes	RNA
T5573	24055-24064	VBN	denotes	localized
T5574	24065-24067	IN	denotes	to
T5575	24068-24071	DT	denotes	the
T5577	24072-24077	JJ	denotes	inner
T5576	24078-24085	NN	denotes	segment
T5578	24085-24087	,	denotes	,
T5579	24087-24088	DT	denotes	a
T5580	24089-24096	NN	denotes	finding
T5581	24097-24104	JJ	denotes	typical
T5582	24105-24108	IN	denotes	for
T5583	24109-24117	NN	denotes	proteins
T5584	24118-24126	VBN	denotes	targeted
T5585	24127-24129	IN	denotes	to
T5586	24130-24133	DT	denotes	the
T5588	24134-24139	JJ	denotes	outer
T5587	24140-24147	NN	denotes	segment
T5589	24147-24148	.	denotes	.
T5590	24148-24248	sentence	denotes	Future analyses of the function of these genes might reveal their role in outer segment biogenesis.
T5591	24149-24155	JJ	denotes	Future
T5592	24156-24164	NNS	denotes	analyses
T5594	24165-24167	IN	denotes	of
T5595	24168-24171	DT	denotes	the
T5596	24172-24180	NN	denotes	function
T5597	24181-24183	IN	denotes	of
T5598	24184-24189	DT	denotes	these
T5599	24190-24195	NNS	denotes	genes
T5600	24196-24201	MD	denotes	might
T5593	24202-24208	VB	denotes	reveal
T5601	24209-24214	PRP$	denotes	their
T5602	24215-24219	NN	denotes	role
T5603	24220-24222	IN	denotes	in
T5604	24223-24228	JJ	denotes	outer
T5605	24229-24236	NN	denotes	segment
T5606	24237-24247	NN	denotes	biogenesis
T5607	24247-24248	.	denotes	.
T5608	24248-24341	sentence	denotes	Finally, polarization of photoreceptors was found to be largely intact, as was ciliogenesis.
T5609	24249-24256	RB	denotes	Finally
T5611	24256-24258	,	denotes	,
T5612	24258-24270	NN	denotes	polarization
T5613	24271-24273	IN	denotes	of
T5614	24274-24288	NNS	denotes	photoreceptors
T5615	24289-24292	VBD	denotes	was
T5610	24293-24298	VBN	denotes	found
T5616	24299-24301	TO	denotes	to
T5617	24302-24304	VB	denotes	be
T5618	24305-24312	RB	denotes	largely
T5619	24313-24319	JJ	denotes	intact
T5620	24319-24321	,	denotes	,
T5621	24321-24323	IN	denotes	as
T5622	24324-24327	VBD	denotes	was
T5623	24328-24340	NN	denotes	ciliogenesis
T5624	24340-24341	.	denotes	.
T5625	24341-24452	sentence	denotes	Another LCA gene, CRB1, and a related gene CRB3, have been implicated in ciliogenesis in in vitro models [46].
T5626	24342-24349	DT	denotes	Another
T5628	24350-24353	NN	denotes	LCA
T5627	24354-24358	NN	denotes	gene
T5630	24358-24360	,	denotes	,
T5631	24360-24364	NN	denotes	CRB1
T5632	24364-24366	,	denotes	,
T5633	24366-24369	CC	denotes	and
T5634	24370-24371	DT	denotes	a
T5636	24372-24379	JJ	denotes	related
T5635	24380-24384	NN	denotes	gene
T5637	24385-24389	NN	denotes	CRB3
T5638	24389-24391	,	denotes	,
T5639	24391-24395	VBP	denotes	have
T5640	24396-24400	VBN	denotes	been
T5629	24401-24411	VBN	denotes	implicated
T5641	24412-24414	IN	denotes	in
T5642	24415-24427	NN	denotes	ciliogenesis
T5643	24428-24430	IN	denotes	in
T5644	24431-24433	FW	denotes	in
T5645	24434-24439	FW	denotes	vitro
T5646	24440-24446	NNS	denotes	models
T5647	24447-24448	-LRB-	denotes	[
T5648	24448-24450	CD	denotes	46
T5649	24450-24451	-RRB-	denotes	]
T5650	24451-24452	.	denotes	.
T5651	24452-24551	sentence	denotes	The Drosophila homologue of CRB1, Crumbs, has been implicated in photoreceptor morphogenesis [47].
T5652	24453-24456	DT	denotes	The
T5654	24457-24467	NNP	denotes	Drosophila
T5653	24468-24477	NN	denotes	homologue
T5656	24478-24480	IN	denotes	of
T5657	24481-24485	NN	denotes	CRB1
T5658	24485-24487	,	denotes	,
T5659	24487-24493	NNP	denotes	Crumbs
T5660	24493-24495	,	denotes	,
T5661	24495-24498	VBZ	denotes	has
T5662	24499-24503	VBN	denotes	been
T5655	24504-24514	VBN	denotes	implicated
T5663	24515-24517	IN	denotes	in
T5664	24518-24531	NN	denotes	photoreceptor
T5665	24532-24545	NN	denotes	morphogenesis
T5666	24546-24547	-LRB-	denotes	[
T5667	24547-24549	CD	denotes	47
T5668	24549-24550	-RRB-	denotes	]
T5669	24550-24551	.	denotes	.
T5670	24551-24783	sentence	denotes	However, the spontaneously occurring mouse mutant in CRB1, the Rd8 mouse, develops shortened outer segments that subsequently degenerate [48], suggesting that photoreceptor polarization and synaptogenesis are intact in this mutant.
T5671	24552-24559	RB	denotes	However
T5673	24559-24561	,	denotes	,
T5674	24561-24564	DT	denotes	the
T5676	24565-24578	RB	denotes	spontaneously
T5677	24579-24588	VBG	denotes	occurring
T5678	24589-24594	NN	denotes	mouse
T5675	24595-24601	NN	denotes	mutant
T5679	24602-24604	IN	denotes	in
T5680	24605-24609	NN	denotes	CRB1
T5681	24609-24611	,	denotes	,
T5682	24611-24614	DT	denotes	the
T5684	24615-24618	NN	denotes	Rd8
T5683	24619-24624	NN	denotes	mouse
T5685	24624-24626	,	denotes	,
T5672	24626-24634	VBZ	denotes	develops
T5686	24635-24644	VBN	denotes	shortened
T5688	24645-24650	JJ	denotes	outer
T5687	24651-24659	NNS	denotes	segments
T5689	24660-24664	WDT	denotes	that
T5691	24665-24677	RB	denotes	subsequently
T5690	24678-24688	VBP	denotes	degenerate
T5692	24689-24690	-LRB-	denotes	[
T5693	24690-24692	CD	denotes	48
T5694	24692-24693	-RRB-	denotes	]
T5695	24693-24695	,	denotes	,
T5696	24695-24705	VBG	denotes	suggesting
T5697	24706-24710	IN	denotes	that
T5699	24711-24724	NN	denotes	photoreceptor
T5700	24725-24737	NN	denotes	polarization
T5701	24738-24741	CC	denotes	and
T5702	24742-24756	NN	denotes	synaptogenesis
T5698	24757-24760	VBP	denotes	are
T5703	24761-24767	JJ	denotes	intact
T5704	24768-24770	IN	denotes	in
T5705	24771-24775	DT	denotes	this
T5706	24776-24782	NN	denotes	mutant
T5707	24782-24783	.	denotes	.
T5708	24783-24923	sentence	denotes	While CRB1 and Crx have been both linked to LCA, further work is necessary to determine if their function is linked in retinal development.
T5709	24784-24789	IN	denotes	While
T5711	24790-24794	NN	denotes	CRB1
T5712	24795-24798	CC	denotes	and
T5713	24799-24802	NN	denotes	Crx
T5714	24803-24807	VBP	denotes	have
T5715	24808-24812	VBN	denotes	been
T5716	24813-24817	RB	denotes	both
T5710	24818-24824	VBN	denotes	linked
T5718	24825-24827	IN	denotes	to
T5719	24828-24831	NN	denotes	LCA
T5720	24831-24833	,	denotes	,
T5721	24833-24840	JJ	denotes	further
T5722	24841-24845	NN	denotes	work
T5717	24846-24848	VBZ	denotes	is
T5723	24849-24858	JJ	denotes	necessary
T5724	24859-24861	TO	denotes	to
T5725	24862-24871	VB	denotes	determine
T5726	24872-24874	IN	denotes	if
T5728	24875-24880	PRP$	denotes	their
T5729	24881-24889	NN	denotes	function
T5730	24890-24892	VBZ	denotes	is
T5727	24893-24899	VBN	denotes	linked
T5731	24900-24902	IN	denotes	in
T5732	24903-24910	JJ	denotes	retinal
T5733	24911-24922	NN	denotes	development
T5734	24922-24923	.	denotes	.
T6165	24925-24939	NN	denotes	Synaptogenesis
T6167	24940-24942	VBZ	denotes	is
T6166	24943-24952	VBN	denotes	perturbed
T6168	24953-24955	IN	denotes	in
T6169	24956-24959	NN	denotes	Crx
T6171	24959-24960	SYM	denotes	-
T6172	24960-24961	HYPH	denotes	/
T6173	24961-24962	SYM	denotes	-
T6170	24963-24977	NNS	denotes	photoreceptors
T6174	24977-25079	sentence	denotes	The Crx-/- mouse demonstrates the most severe abnormality of photoreceptor synapses reported to date.
T6175	24978-24981	DT	denotes	The
T6177	24982-24985	NN	denotes	Crx
T6178	24985-24986	SYM	denotes	-
T6179	24986-24987	HYPH	denotes	/
T6180	24987-24988	SYM	denotes	-
T6176	24989-24994	NN	denotes	mouse
T6181	24995-25007	VBZ	denotes	demonstrates
T6182	25008-25011	DT	denotes	the
T6184	25012-25016	RBS	denotes	most
T6185	25017-25023	JJ	denotes	severe
T6183	25024-25035	NN	denotes	abnormality
T6186	25036-25038	IN	denotes	of
T6187	25039-25052	NN	denotes	photoreceptor
T6188	25053-25061	NNS	denotes	synapses
T6189	25062-25070	VBN	denotes	reported
T6190	25071-25073	IN	denotes	to
T6191	25074-25078	NN	denotes	date
T6192	25078-25079	.	denotes	.
T6193	25079-25218	sentence	denotes	The peripherin-/- mouse develops a normal complement of photoreceptor terminals which then degenerate as the photoreceptors are lost [30].
T6194	25080-25083	DT	denotes	The
T6196	25084-25094	NN	denotes	peripherin
T6197	25094-25095	SYM	denotes	-
T6198	25095-25096	HYPH	denotes	/
T6199	25096-25097	SYM	denotes	-
T6195	25098-25103	NN	denotes	mouse
T6200	25104-25112	VBZ	denotes	develops
T6201	25113-25114	DT	denotes	a
T6203	25115-25121	JJ	denotes	normal
T6202	25122-25132	NN	denotes	complement
T6204	25133-25135	IN	denotes	of
T6205	25136-25149	NN	denotes	photoreceptor
T6206	25150-25159	NNS	denotes	terminals
T6207	25160-25165	WDT	denotes	which
T6209	25166-25170	RB	denotes	then
T6208	25171-25181	VBP	denotes	degenerate
T6210	25182-25184	IN	denotes	as
T6212	25185-25188	DT	denotes	the
T6213	25189-25203	NNS	denotes	photoreceptors
T6214	25204-25207	VBP	denotes	are
T6211	25208-25212	VBN	denotes	lost
T6215	25213-25214	-LRB-	denotes	[
T6216	25214-25216	CD	denotes	30
T6217	25216-25217	-RRB-	denotes	]
T6218	25217-25218	.	denotes	.
T6219	25218-25392	sentence	denotes	Also, similarly in rhodopsin (Rho) and cyclic nucleotide-gated channel, alpha-3 (CNGA3) double knockout mice (Rho-/-, CNGA3-/-), synapses are reported to form normally [49].
T6220	25219-25223	RB	denotes	Also
T6222	25223-25225	,	denotes	,
T6223	25225-25234	RB	denotes	similarly
T6224	25235-25237	IN	denotes	in
T6225	25238-25247	NN	denotes	rhodopsin
T6226	25248-25249	-LRB-	denotes	(
T6227	25249-25252	NN	denotes	Rho
T6228	25252-25253	-RRB-	denotes	)
T6229	25254-25257	CC	denotes	and
T6230	25258-25264	JJ	denotes	cyclic
T6232	25265-25275	NN	denotes	nucleotide
T6234	25275-25276	HYPH	denotes	-
T6233	25276-25281	VBN	denotes	gated
T6231	25282-25289	NN	denotes	channel
T6236	25289-25291	,	denotes	,
T6235	25291-25296	NN	denotes	alpha
T6238	25296-25297	HYPH	denotes	-
T6239	25297-25298	CD	denotes	3
T6240	25299-25300	-LRB-	denotes	(
T6241	25300-25305	NN	denotes	CNGA3
T6242	25305-25306	-RRB-	denotes	)
T6243	25307-25313	JJ	denotes	double
T6244	25314-25322	NN	denotes	knockout
T6237	25323-25327	NNS	denotes	mice
T6245	25328-25329	-LRB-	denotes	(
T6246	25329-25332	NN	denotes	Rho
T6247	25332-25333	SYM	denotes	-
T6248	25333-25334	HYPH	denotes	/
T6249	25334-25335	SYM	denotes	-
T6250	25335-25337	,	denotes	,
T6251	25337-25342	NN	denotes	CNGA3
T6252	25342-25343	SYM	denotes	-
T6253	25343-25344	HYPH	denotes	/
T6254	25344-25345	SYM	denotes	-
T6255	25345-25346	-RRB-	denotes	)
T6256	25346-25348	,	denotes	,
T6257	25348-25356	NNS	denotes	synapses
T6258	25357-25360	VBP	denotes	are
T6221	25361-25369	VBN	denotes	reported
T6259	25370-25372	TO	denotes	to
T6260	25373-25377	VB	denotes	form
T6261	25378-25386	RB	denotes	normally
T6262	25387-25388	-LRB-	denotes	[
T6263	25388-25390	CD	denotes	49
T6264	25390-25391	-RRB-	denotes	]
T6265	25391-25392	.	denotes	.
T6266	25392-25510	sentence	denotes	These observations demonstrate that photoreceptor synaptogenesis can occur in the absence of outer segment formation.
T6267	25393-25398	DT	denotes	These
T6268	25399-25411	NNS	denotes	observations
T6269	25412-25423	VBP	denotes	demonstrate
T6270	25424-25428	IN	denotes	that
T6272	25429-25442	NN	denotes	photoreceptor
T6273	25443-25457	NN	denotes	synaptogenesis
T6274	25458-25461	MD	denotes	can
T6271	25462-25467	VB	denotes	occur
T6275	25468-25470	IN	denotes	in
T6276	25471-25474	DT	denotes	the
T6277	25475-25482	NN	denotes	absence
T6278	25483-25485	IN	denotes	of
T6279	25486-25491	JJ	denotes	outer
T6280	25492-25499	NN	denotes	segment
T6281	25500-25509	NN	denotes	formation
T6282	25509-25510	.	denotes	.
T6283	25510-25749	sentence	denotes	In keeping with this observation is the fact that some electroretinogram activity is present in peripherin-/- mice, suggesting that minimal phototransduction is present in these mice, enough to drive activity at the photoreceptor synapse.
T6284	25511-25513	IN	denotes	In
T6286	25514-25521	VBG	denotes	keeping
T6287	25522-25526	IN	denotes	with
T6288	25527-25531	DT	denotes	this
T6289	25532-25543	NN	denotes	observation
T6285	25544-25546	VBZ	denotes	is
T6290	25547-25550	DT	denotes	the
T6291	25551-25555	NN	denotes	fact
T6292	25556-25560	IN	denotes	that
T6294	25561-25565	DT	denotes	some
T6296	25566-25583	NN	denotes	electroretinogram
T6295	25584-25592	NN	denotes	activity
T6293	25593-25595	VBZ	denotes	is
T6297	25596-25603	JJ	denotes	present
T6298	25604-25606	IN	denotes	in
T6299	25607-25617	NN	denotes	peripherin
T6301	25617-25618	SYM	denotes	-
T6302	25618-25619	HYPH	denotes	/
T6303	25619-25620	SYM	denotes	-
T6300	25621-25625	NNS	denotes	mice
T6304	25625-25627	,	denotes	,
T6305	25627-25637	VBG	denotes	suggesting
T6306	25638-25642	IN	denotes	that
T6308	25643-25650	JJ	denotes	minimal
T6309	25651-25668	NN	denotes	phototransduction
T6307	25669-25671	VBZ	denotes	is
T6310	25672-25679	JJ	denotes	present
T6311	25680-25682	IN	denotes	in
T6312	25683-25688	DT	denotes	these
T6313	25689-25693	NNS	denotes	mice
T6314	25693-25695	,	denotes	,
T6315	25695-25701	RB	denotes	enough
T6316	25702-25704	TO	denotes	to
T6317	25705-25710	VB	denotes	drive
T6318	25711-25719	NN	denotes	activity
T6319	25720-25722	IN	denotes	at
T6320	25723-25726	DT	denotes	the
T6322	25727-25740	NN	denotes	photoreceptor
T6321	25741-25748	NN	denotes	synapse
T6323	25748-25749	.	denotes	.
T6324	25749-26046	sentence	denotes	In vitro studies wherein synapse elements are formed in the absence of proper outer segment development and, therefore, possible absence of light-dependent photoreceptor activity, have indicated the independence of phototransduction and synapse formation, at least for the initial stages [50,51].
T6325	25750-25752	FW	denotes	In
T6326	25753-25758	FW	denotes	vitro
T6327	25759-25766	NNS	denotes	studies
T6329	25767-25774	IN	denotes	wherein
T6331	25775-25782	NN	denotes	synapse
T6332	25783-25791	NNS	denotes	elements
T6333	25792-25795	VBP	denotes	are
T6330	25796-25802	VBN	denotes	formed
T6334	25803-25805	IN	denotes	in
T6335	25806-25809	DT	denotes	the
T6336	25810-25817	NN	denotes	absence
T6337	25818-25820	IN	denotes	of
T6338	25821-25827	JJ	denotes	proper
T6340	25828-25833	JJ	denotes	outer
T6341	25834-25841	NN	denotes	segment
T6339	25842-25853	NN	denotes	development
T6342	25854-25857	CC	denotes	and
T6343	25857-25859	,	denotes	,
T6344	25859-25868	RB	denotes	therefore
T6346	25868-25870	,	denotes	,
T6347	25870-25878	JJ	denotes	possible
T6345	25879-25886	NN	denotes	absence
T6348	25887-25889	IN	denotes	of
T6349	25890-25895	NN	denotes	light
T6351	25895-25896	HYPH	denotes	-
T6350	25896-25905	JJ	denotes	dependent
T6353	25906-25919	NN	denotes	photoreceptor
T6352	25920-25928	NN	denotes	activity
T6354	25928-25930	,	denotes	,
T6355	25930-25934	VBP	denotes	have
T6328	25935-25944	VBN	denotes	indicated
T6356	25945-25948	DT	denotes	the
T6357	25949-25961	NN	denotes	independence
T6358	25962-25964	IN	denotes	of
T6359	25965-25982	NN	denotes	phototransduction
T6360	25983-25986	CC	denotes	and
T6361	25987-25994	NN	denotes	synapse
T6362	25995-26004	NN	denotes	formation
T6363	26004-26006	,	denotes	,
T6364	26006-26008	RB	denotes	at
T6365	26009-26014	RBS	denotes	least
T6366	26015-26018	IN	denotes	for
T6367	26019-26022	DT	denotes	the
T6369	26023-26030	JJ	denotes	initial
T6368	26031-26037	NNS	denotes	stages
T6370	26038-26039	-LRB-	denotes	[
T6372	26039-26041	CD	denotes	50
T6373	26041-26042	,	denotes	,
T6371	26042-26044	CD	denotes	51
T6374	26044-26045	-RRB-	denotes	]
T6375	26045-26046	.	denotes	.
T6376	26046-26200	sentence	denotes	These data then suggest that the fact that the Crx-/- photoreceptors do not have proper synaptic endings is not due to a lack of outer segment formation.
T6377	26047-26052	DT	denotes	These
T6378	26053-26057	NNS	denotes	data
T6380	26058-26062	RB	denotes	then
T6379	26063-26070	VBP	denotes	suggest
T6381	26071-26075	IN	denotes	that
T6383	26076-26079	DT	denotes	the
T6384	26080-26084	NN	denotes	fact
T6385	26085-26089	IN	denotes	that
T6387	26090-26093	DT	denotes	the
T6389	26094-26097	NN	denotes	Crx
T6390	26097-26098	SYM	denotes	-
T6391	26098-26099	HYPH	denotes	/
T6392	26099-26100	SYM	denotes	-
T6388	26101-26115	NNS	denotes	photoreceptors
T6393	26116-26118	VBP	denotes	do
T6394	26119-26122	RB	denotes	not
T6386	26123-26127	VB	denotes	have
T6395	26128-26134	JJ	denotes	proper
T6397	26135-26143	JJ	denotes	synaptic
T6396	26144-26151	NNS	denotes	endings
T6382	26152-26154	VBZ	denotes	is
T6398	26155-26158	RB	denotes	not
T6399	26159-26162	IN	denotes	due
T6400	26163-26165	IN	denotes	to
T6401	26166-26167	DT	denotes	a
T6402	26168-26172	NN	denotes	lack
T6403	26173-26175	IN	denotes	of
T6404	26176-26181	JJ	denotes	outer
T6405	26182-26189	NN	denotes	segment
T6406	26190-26199	NN	denotes	formation
T6407	26199-26200	.	denotes	.
T6408	26200-26367	sentence	denotes	A more likely explanation is that Crx plays a role in photoreceptor synapse formation, perhaps by regulating directly, or indirectly, important genes in this process.
T6409	26201-26202	DT	denotes	A
T6411	26203-26207	RBR	denotes	more
T6412	26208-26214	JJ	denotes	likely
T6410	26215-26226	NN	denotes	explanation
T6413	26227-26229	VBZ	denotes	is
T6414	26230-26234	IN	denotes	that
T6416	26235-26238	NN	denotes	Crx
T6415	26239-26244	VBZ	denotes	plays
T6417	26245-26246	DT	denotes	a
T6418	26247-26251	NN	denotes	role
T6419	26252-26254	IN	denotes	in
T6420	26255-26268	NN	denotes	photoreceptor
T6421	26269-26276	NN	denotes	synapse
T6422	26277-26286	NN	denotes	formation
T6423	26286-26288	,	denotes	,
T6424	26288-26295	RB	denotes	perhaps
T6425	26296-26298	IN	denotes	by
T6426	26299-26309	VBG	denotes	regulating
T6427	26310-26318	RB	denotes	directly
T6428	26318-26320	,	denotes	,
T6429	26320-26322	CC	denotes	or
T6430	26323-26333	RB	denotes	indirectly
T6431	26333-26335	,	denotes	,
T6432	26335-26344	JJ	denotes	important
T6433	26345-26350	NNS	denotes	genes
T6434	26351-26353	IN	denotes	in
T6435	26354-26358	DT	denotes	this
T6436	26359-26366	NN	denotes	process
T6437	26366-26367	.	denotes	.
T6438	26367-26615	sentence	denotes	Using immunohistochemistry, we examined the expression of common pre-synaptic terminal proteins, including KIF3a, SV2, and synaptophysin, and were unable to observe qualitative differences between Crx-/- and control tissue at P14 (data not shown).
T6439	26368-26373	VBG	denotes	Using
T6441	26374-26394	NN	denotes	immunohistochemistry
T6442	26394-26396	,	denotes	,
T6443	26396-26398	PRP	denotes	we
T6440	26399-26407	VBD	denotes	examined
T6444	26408-26411	DT	denotes	the
T6445	26412-26422	NN	denotes	expression
T6446	26423-26425	IN	denotes	of
T6447	26426-26432	JJ	denotes	common
T6449	26433-26445	JJ	denotes	pre-synaptic
T6450	26446-26454	JJ	denotes	terminal
T6448	26455-26463	NN	denotes	proteins
T6451	26463-26465	,	denotes	,
T6452	26465-26474	VBG	denotes	including
T6453	26475-26480	NN	denotes	KIF3a
T6454	26480-26482	,	denotes	,
T6455	26482-26485	NN	denotes	SV2
T6456	26485-26487	,	denotes	,
T6457	26487-26490	CC	denotes	and
T6458	26491-26504	NN	denotes	synaptophysin
T6459	26504-26506	,	denotes	,
T6460	26506-26509	CC	denotes	and
T6461	26510-26514	VBD	denotes	were
T6462	26515-26521	JJ	denotes	unable
T6463	26522-26524	TO	denotes	to
T6464	26525-26532	VB	denotes	observe
T6465	26533-26544	JJ	denotes	qualitative
T6466	26545-26556	NNS	denotes	differences
T6467	26557-26564	IN	denotes	between
T6468	26565-26568	NN	denotes	Crx
T6470	26568-26569	SYM	denotes	-
T6471	26569-26570	HYPH	denotes	/
T6472	26570-26571	SYM	denotes	-
T6473	26572-26575	CC	denotes	and
T6474	26576-26583	NN	denotes	control
T6469	26584-26590	NN	denotes	tissue
T6475	26591-26593	IN	denotes	at
T6476	26594-26597	NN	denotes	P14
T6477	26598-26599	-LRB-	denotes	(
T6479	26599-26603	NNS	denotes	data
T6480	26604-26607	RB	denotes	not
T6478	26608-26613	VBN	denotes	shown
T6481	26613-26614	-RRB-	denotes	)
T6482	26614-26615	.	denotes	.
T6483	26615-26823	sentence	denotes	Examination of their RNA levels by SAGE showed no significant difference for all 3 genes, though very few tags were recovered from these genes and thus the analysis of RNA levels may not be significant [35].
T6484	26616-26627	NN	denotes	Examination
T6486	26628-26630	IN	denotes	of
T6487	26631-26636	PRP$	denotes	their
T6489	26637-26640	NN	denotes	RNA
T6488	26641-26647	NNS	denotes	levels
T6490	26648-26650	IN	denotes	by
T6491	26651-26655	NN	denotes	SAGE
T6485	26656-26662	VBD	denotes	showed
T6492	26663-26665	DT	denotes	no
T6494	26666-26677	JJ	denotes	significant
T6493	26678-26688	NN	denotes	difference
T6495	26689-26692	IN	denotes	for
T6496	26693-26696	DT	denotes	all
T6498	26697-26698	CD	denotes	3
T6497	26699-26704	NNS	denotes	genes
T6499	26704-26706	,	denotes	,
T6500	26706-26712	IN	denotes	though
T6502	26713-26717	RB	denotes	very
T6503	26718-26721	JJ	denotes	few
T6504	26722-26726	NNS	denotes	tags
T6505	26727-26731	VBD	denotes	were
T6501	26732-26741	VBN	denotes	recovered
T6506	26742-26746	IN	denotes	from
T6507	26747-26752	DT	denotes	these
T6508	26753-26758	NNS	denotes	genes
T6509	26759-26762	CC	denotes	and
T6510	26763-26767	RB	denotes	thus
T6512	26768-26771	DT	denotes	the
T6513	26772-26780	NN	denotes	analysis
T6514	26781-26783	IN	denotes	of
T6515	26784-26787	NN	denotes	RNA
T6516	26788-26794	NNS	denotes	levels
T6517	26795-26798	MD	denotes	may
T6518	26799-26802	RB	denotes	not
T6511	26803-26805	VB	denotes	be
T6519	26806-26817	JJ	denotes	significant
T6520	26818-26819	-LRB-	denotes	[
T6521	26819-26821	CD	denotes	35
T6522	26821-26822	-RRB-	denotes	]
T6523	26822-26823	.	denotes	.
T6524	26823-27035	sentence	denotes	However, since other genes expressed in photoreceptors were significantly altered in their expression level in the Crx-/- mouse, there are many candidates that could be important for photoreceptor morphogenesis.
T6525	26824-26831	RB	denotes	However
T6527	26831-26833	,	denotes	,
T6528	26833-26838	IN	denotes	since
T6530	26839-26844	JJ	denotes	other
T6531	26845-26850	NNS	denotes	genes
T6532	26851-26860	VBN	denotes	expressed
T6533	26861-26863	IN	denotes	in
T6534	26864-26878	NNS	denotes	photoreceptors
T6535	26879-26883	VBD	denotes	were
T6536	26884-26897	RB	denotes	significantly
T6529	26898-26905	VBN	denotes	altered
T6537	26906-26908	IN	denotes	in
T6538	26909-26914	PRP$	denotes	their
T6540	26915-26925	NN	denotes	expression
T6539	26926-26931	NN	denotes	level
T6541	26932-26934	IN	denotes	in
T6542	26935-26938	DT	denotes	the
T6544	26939-26942	NN	denotes	Crx
T6545	26942-26943	SYM	denotes	-
T6546	26943-26944	HYPH	denotes	/
T6547	26944-26945	SYM	denotes	-
T6543	26946-26951	NN	denotes	mouse
T6548	26951-26953	,	denotes	,
T6549	26953-26958	EX	denotes	there
T6526	26959-26962	VBP	denotes	are
T6550	26963-26967	JJ	denotes	many
T6551	26968-26978	NNS	denotes	candidates
T6552	26979-26983	WDT	denotes	that
T6554	26984-26989	MD	denotes	could
T6553	26990-26992	VB	denotes	be
T6555	26993-27002	JJ	denotes	important
T6556	27003-27006	IN	denotes	for
T6557	27007-27020	NN	denotes	photoreceptor
T6558	27021-27034	NN	denotes	morphogenesis
T6559	27034-27035	.	denotes	.
T6560	27035-27307	sentence	denotes	Tags from three genes from proteins expressed in photoreceptor terminals were found to be decreased in a statistically significant fashion, namely the HGF-regulated tyrosine kinase substrate, the CRIPT protein, and synaptotagmin 1 (Blackshaw and Cepko, unpublished data).
T6561	27036-27040	NNS	denotes	Tags
T6563	27041-27045	IN	denotes	from
T6564	27046-27051	CD	denotes	three
T6565	27052-27057	NNS	denotes	genes
T6566	27058-27062	IN	denotes	from
T6567	27063-27071	NN	denotes	proteins
T6568	27072-27081	VBN	denotes	expressed
T6569	27082-27084	IN	denotes	in
T6570	27085-27098	NN	denotes	photoreceptor
T6571	27099-27108	NNS	denotes	terminals
T6572	27109-27113	VBD	denotes	were
T6562	27114-27119	VBN	denotes	found
T6573	27120-27122	TO	denotes	to
T6575	27123-27125	VB	denotes	be
T6574	27126-27135	VBN	denotes	decreased
T6576	27136-27138	IN	denotes	in
T6577	27139-27140	DT	denotes	a
T6579	27141-27154	RB	denotes	statistically
T6580	27155-27166	JJ	denotes	significant
T6578	27167-27174	NN	denotes	fashion
T6581	27174-27176	,	denotes	,
T6582	27176-27182	RB	denotes	namely
T6584	27183-27186	DT	denotes	the
T6585	27187-27190	NN	denotes	HGF
T6587	27190-27191	HYPH	denotes	-
T6586	27191-27200	VBN	denotes	regulated
T6588	27201-27209	NN	denotes	tyrosine
T6589	27210-27216	NN	denotes	kinase
T6583	27217-27226	NN	denotes	substrate
T6590	27226-27228	,	denotes	,
T6591	27228-27231	DT	denotes	the
T6593	27232-27237	NN	denotes	CRIPT
T6592	27238-27245	NN	denotes	protein
T6594	27245-27247	,	denotes	,
T6595	27247-27250	CC	denotes	and
T6596	27251-27264	NN	denotes	synaptotagmin
T6597	27265-27266	CD	denotes	1
T6598	27267-27268	-LRB-	denotes	(
T6599	27268-27277	NNP	denotes	Blackshaw
T6600	27278-27281	CC	denotes	and
T6601	27282-27287	NNP	denotes	Cepko
T6602	27287-27289	,	denotes	,
T6603	27289-27300	JJ	denotes	unpublished
T6604	27301-27305	NNS	denotes	data
T6605	27305-27306	-RRB-	denotes	)
T6606	27306-27307	.	denotes	.
T6607	27307-27514	sentence	denotes	An example of a gene that was increased in the Crx-/- retina is HRG4 (a homologue of the C. elegans Unc119 gene) (Blackshaw and Cepko, unpublished data) which encodes a component of the ribbon synapse [33].
T6608	27308-27310	DT	denotes	An
T6609	27311-27318	NN	denotes	example
T6611	27319-27321	IN	denotes	of
T6612	27322-27323	DT	denotes	a
T6613	27324-27328	NN	denotes	gene
T6614	27329-27333	WDT	denotes	that
T6616	27334-27337	VBD	denotes	was
T6615	27338-27347	VBN	denotes	increased
T6617	27348-27350	IN	denotes	in
T6618	27351-27354	DT	denotes	the
T6620	27355-27358	NN	denotes	Crx
T6621	27358-27359	SYM	denotes	-
T6622	27359-27360	HYPH	denotes	/
T6623	27360-27361	SYM	denotes	-
T6619	27362-27368	NN	denotes	retina
T6610	27369-27371	VBZ	denotes	is
T6624	27372-27376	NN	denotes	HRG4
T6625	27377-27378	-LRB-	denotes	(
T6626	27378-27379	DT	denotes	a
T6627	27380-27389	NN	denotes	homologue
T6628	27390-27392	IN	denotes	of
T6629	27393-27396	DT	denotes	the
T6631	27397-27399	NNP	denotes	C.
T6632	27400-27407	NNP	denotes	elegans
T6633	27408-27414	NN	denotes	Unc119
T6630	27415-27419	NN	denotes	gene
T6634	27419-27420	-RRB-	denotes	)
T6635	27421-27422	-LRB-	denotes	(
T6636	27422-27431	NNP	denotes	Blackshaw
T6637	27432-27435	CC	denotes	and
T6638	27436-27441	NNP	denotes	Cepko
T6639	27441-27443	,	denotes	,
T6640	27443-27454	JJ	denotes	unpublished
T6641	27455-27459	NNS	denotes	data
T6642	27459-27460	-RRB-	denotes	)
T6643	27461-27466	WDT	denotes	which
T6644	27467-27474	VBZ	denotes	encodes
T6645	27475-27476	DT	denotes	a
T6646	27477-27486	NN	denotes	component
T6647	27487-27489	IN	denotes	of
T6648	27490-27493	DT	denotes	the
T6650	27494-27500	NN	denotes	ribbon
T6649	27501-27508	NN	denotes	synapse
T6651	27509-27510	-LRB-	denotes	[
T6652	27510-27512	CD	denotes	33
T6653	27512-27513	-RRB-	denotes	]
T6654	27513-27514	.	denotes	.
T6655	27514-27615	sentence	denotes	The fact that it is upregulated might indicate a response to the lack of proper terminal structures.
T6656	27515-27518	DT	denotes	The
T6657	27519-27523	NN	denotes	fact
T6659	27524-27528	IN	denotes	that
T6661	27529-27531	PRP	denotes	it
T6662	27532-27534	VBZ	denotes	is
T6660	27535-27546	VBN	denotes	upregulated
T6663	27547-27552	MD	denotes	might
T6658	27553-27561	VB	denotes	indicate
T6664	27562-27563	DT	denotes	a
T6665	27564-27572	NN	denotes	response
T6666	27573-27575	IN	denotes	to
T6667	27576-27579	DT	denotes	the
T6668	27580-27584	NN	denotes	lack
T6669	27585-27587	IN	denotes	of
T6670	27588-27594	JJ	denotes	proper
T6672	27595-27603	JJ	denotes	terminal
T6671	27604-27614	NNS	denotes	structures
T6673	27614-27615	.	denotes	.
T6674	27615-27811	sentence	denotes	Several other genes encoding putative cytoskeletal elements also were increased (e.g. microtubule associated protein 4) or decreased (e.g. cofilin 1) in the Crx-/- retina, with P values of <.005.
T6675	27616-27623	JJ	denotes	Several
T6677	27624-27629	JJ	denotes	other
T6676	27630-27635	NNS	denotes	genes
T6679	27636-27644	VBG	denotes	encoding
T6680	27645-27653	JJ	denotes	putative
T6682	27654-27666	JJ	denotes	cytoskeletal
T6681	27667-27675	NNS	denotes	elements
T6683	27676-27680	RB	denotes	also
T6684	27681-27685	VBD	denotes	were
T6678	27686-27695	VBN	denotes	increased
T6685	27696-27697	-LRB-	denotes	(
T6687	27697-27701	FW	denotes	e.g.
T6688	27702-27713	NN	denotes	microtubule
T6689	27714-27724	VBN	denotes	associated
T6686	27725-27732	NN	denotes	protein
T6690	27733-27734	CD	denotes	4
T6691	27734-27735	-RRB-	denotes	)
T6692	27736-27738	CC	denotes	or
T6693	27739-27748	VBN	denotes	decreased
T6694	27749-27750	-LRB-	denotes	(
T6696	27750-27754	FW	denotes	e.g.
T6695	27755-27762	NN	denotes	cofilin
T6697	27763-27764	CD	denotes	1
T6698	27764-27765	-RRB-	denotes	)
T6699	27766-27768	IN	denotes	in
T6700	27769-27772	DT	denotes	the
T6702	27773-27776	NN	denotes	Crx
T6703	27776-27777	SYM	denotes	-
T6704	27777-27778	HYPH	denotes	/
T6705	27778-27779	SYM	denotes	-
T6701	27780-27786	NN	denotes	retina
T6706	27786-27788	,	denotes	,
T6707	27788-27792	IN	denotes	with
T6708	27793-27794	NN	denotes	P
T6709	27795-27801	NNS	denotes	values
T6710	27802-27804	IN	denotes	of
T6711	27805-27806	SYM	denotes	<
T6712	27806-27810	CD	denotes	.005
T6713	27810-27811	.	denotes	.
T6714	27811-28070	sentence	denotes	It is not known whether any of these genes are involved in building or regulating synaptic structures, but they are now genes that might lead to a better understanding of the construction and function of the relatively unique structure of the ribbon synapse.
T6715	27812-27814	PRP	denotes	It
T6717	27815-27817	VBZ	denotes	is
T6718	27818-27821	RB	denotes	not
T6716	27822-27827	VBN	denotes	known
T6719	27828-27835	IN	denotes	whether
T6721	27836-27839	DT	denotes	any
T6722	27840-27842	IN	denotes	of
T6723	27843-27848	DT	denotes	these
T6724	27849-27854	NNS	denotes	genes
T6725	27855-27858	VBP	denotes	are
T6720	27859-27867	VBN	denotes	involved
T6726	27868-27870	IN	denotes	in
T6727	27871-27879	VBG	denotes	building
T6728	27880-27882	CC	denotes	or
T6729	27883-27893	VBG	denotes	regulating
T6730	27894-27902	JJ	denotes	synaptic
T6731	27903-27913	NNS	denotes	structures
T6732	27913-27915	,	denotes	,
T6733	27915-27918	CC	denotes	but
T6734	27919-27923	PRP	denotes	they
T6735	27924-27927	VBP	denotes	are
T6736	27928-27931	RB	denotes	now
T6737	27932-27937	NNS	denotes	genes
T6738	27938-27942	WDT	denotes	that
T6740	27943-27948	MD	denotes	might
T6739	27949-27953	VB	denotes	lead
T6741	27954-27956	IN	denotes	to
T6742	27957-27958	DT	denotes	a
T6744	27959-27965	JJR	denotes	better
T6743	27966-27979	NN	denotes	understanding
T6745	27980-27982	IN	denotes	of
T6746	27983-27986	DT	denotes	the
T6747	27987-27999	NN	denotes	construction
T6748	28000-28003	CC	denotes	and
T6749	28004-28012	NN	denotes	function
T6750	28013-28015	IN	denotes	of
T6751	28016-28019	DT	denotes	the
T6753	28020-28030	RB	denotes	relatively
T6754	28031-28037	JJ	denotes	unique
T6752	28038-28047	NN	denotes	structure
T6755	28048-28050	IN	denotes	of
T6756	28051-28054	DT	denotes	the
T6758	28055-28061	NN	denotes	ribbon
T6757	28062-28069	NN	denotes	synapse
T6759	28069-28070	.	denotes	.
T6760	28070-28216	sentence	denotes	Abnormal photoreceptor terminal formation was noted in a study that examined retinal development in the laminin beta2 chain-deficient mouse [52].
T6761	28071-28079	JJ	denotes	Abnormal
T6763	28080-28093	NN	denotes	photoreceptor
T6764	28094-28102	NN	denotes	terminal
T6762	28103-28112	NN	denotes	formation
T6766	28113-28116	VBD	denotes	was
T6765	28117-28122	VBN	denotes	noted
T6767	28123-28125	IN	denotes	in
T6768	28126-28127	DT	denotes	a
T6769	28128-28133	NN	denotes	study
T6770	28134-28138	WDT	denotes	that
T6771	28139-28147	VBD	denotes	examined
T6772	28148-28155	JJ	denotes	retinal
T6773	28156-28167	NN	denotes	development
T6774	28168-28170	IN	denotes	in
T6775	28171-28174	DT	denotes	the
T6777	28175-28182	NN	denotes	laminin
T6779	28183-28188	NN	denotes	beta2
T6778	28189-28194	NN	denotes	chain
T6781	28194-28195	HYPH	denotes	-
T6780	28195-28204	JJ	denotes	deficient
T6776	28205-28210	NN	denotes	mouse
T6782	28211-28212	-LRB-	denotes	[
T6783	28212-28214	CD	denotes	52
T6784	28214-28215	-RRB-	denotes	]
T6785	28215-28216	.	denotes	.
T6786	28216-28262	sentence	denotes	Several pathologies were noted in these mice.
T6787	28217-28224	JJ	denotes	Several
T6788	28225-28236	NNS	denotes	pathologies
T6790	28237-28241	VBD	denotes	were
T6789	28242-28247	VBN	denotes	noted
T6791	28248-28250	IN	denotes	in
T6792	28251-28256	DT	denotes	these
T6793	28257-28261	NNS	denotes	mice
T6794	28261-28262	.	denotes	.
T6795	28262-28455	sentence	denotes	First, laminin beta2 chain-deficient mice displayed abnormal outer segment elongation, but a more mild phenotype than that of the Crx-/- mice; the outer segments were reduced by 50% in length.
T6796	28263-28268	RB	denotes	First
T6798	28268-28270	,	denotes	,
T6799	28270-28277	NN	denotes	laminin
T6801	28278-28283	NN	denotes	beta2
T6800	28284-28289	NN	denotes	chain
T6803	28289-28290	HYPH	denotes	-
T6802	28290-28299	JJ	denotes	deficient
T6804	28300-28304	NNS	denotes	mice
T6797	28305-28314	VBD	denotes	displayed
T6806	28315-28323	JJ	denotes	abnormal
T6808	28324-28329	JJ	denotes	outer
T6809	28330-28337	NN	denotes	segment
T6807	28338-28348	NN	denotes	elongation
T6810	28348-28350	,	denotes	,
T6811	28350-28353	CC	denotes	but
T6812	28354-28355	DT	denotes	a
T6814	28356-28360	RBR	denotes	more
T6815	28361-28365	JJ	denotes	mild
T6813	28366-28375	NN	denotes	phenotype
T6816	28376-28380	IN	denotes	than
T6817	28381-28385	DT	denotes	that
T6818	28386-28388	IN	denotes	of
T6819	28389-28392	DT	denotes	the
T6821	28393-28396	NN	denotes	Crx
T6822	28396-28397	SYM	denotes	-
T6823	28397-28398	HYPH	denotes	/
T6824	28398-28399	SYM	denotes	-
T6820	28400-28404	NNS	denotes	mice
T6825	28404-28405	:	denotes	;
T6826	28406-28409	DT	denotes	the
T6828	28410-28415	JJ	denotes	outer
T6827	28416-28424	NNS	denotes	segments
T6829	28425-28429	VBD	denotes	were
T6805	28430-28437	VBN	denotes	reduced
T6830	28438-28440	IN	denotes	by
T6831	28441-28443	CD	denotes	50
T6832	28443-28444	NN	denotes	%
T6833	28445-28447	IN	denotes	in
T6834	28448-28454	NN	denotes	length
T6835	28454-28455	.	denotes	.
T6836	28455-28591	sentence	denotes	Also photoreceptor terminals were perturbed in laminin beta2 mutants, but again the phenotype was more subtle then that of Crx-/- mice.
T6837	28456-28460	RB	denotes	Also
T6839	28461-28474	NN	denotes	photoreceptor
T6840	28475-28484	NNS	denotes	terminals
T6841	28485-28489	VBD	denotes	were
T6838	28490-28499	VBN	denotes	perturbed
T6842	28500-28502	IN	denotes	in
T6843	28503-28510	NN	denotes	laminin
T6844	28511-28516	NN	denotes	beta2
T6845	28517-28524	NNS	denotes	mutants
T6846	28524-28526	,	denotes	,
T6847	28526-28529	CC	denotes	but
T6848	28530-28535	RB	denotes	again
T6850	28536-28539	DT	denotes	the
T6851	28540-28549	NN	denotes	phenotype
T6849	28550-28553	VBD	denotes	was
T6852	28554-28558	RBR	denotes	more
T6853	28559-28565	JJ	denotes	subtle
T6854	28566-28570	IN	denotes	then
T6855	28571-28575	DT	denotes	that
T6856	28576-28578	IN	denotes	of
T6857	28579-28582	NN	denotes	Crx
T6859	28582-28583	SYM	denotes	-
T6860	28583-28584	HYPH	denotes	/
T6861	28584-28585	SYM	denotes	-
T6858	28586-28590	NNS	denotes	mice
T6862	28590-28591	.	denotes	.
T6863	28591-28795	sentence	denotes	The outer plexiform layer of the beta2-deficient retinas demonstrated only 7% normal invaginating synapses, while the remainder had various pathologies, including floating synaptic ribbons, as seen here.
T6864	28592-28595	DT	denotes	The
T6866	28596-28601	JJ	denotes	outer
T6867	28602-28611	NN	denotes	plexiform
T6865	28612-28617	NN	denotes	layer
T6869	28618-28620	IN	denotes	of
T6870	28621-28624	DT	denotes	the
T6872	28625-28630	NN	denotes	beta2
T6874	28630-28631	HYPH	denotes	-
T6873	28631-28640	JJ	denotes	deficient
T6871	28641-28648	NNS	denotes	retinas
T6868	28649-28661	VBD	denotes	demonstrated
T6875	28662-28666	RB	denotes	only
T6876	28667-28668	CD	denotes	7
T6877	28668-28669	NN	denotes	%
T6879	28670-28676	JJ	denotes	normal
T6880	28677-28689	VBG	denotes	invaginating
T6878	28690-28698	NNS	denotes	synapses
T6881	28698-28700	,	denotes	,
T6882	28700-28705	IN	denotes	while
T6884	28706-28709	DT	denotes	the
T6885	28710-28719	NN	denotes	remainder
T6883	28720-28723	VBD	denotes	had
T6886	28724-28731	JJ	denotes	various
T6887	28732-28743	NNS	denotes	pathologies
T6888	28743-28745	,	denotes	,
T6889	28745-28754	VBG	denotes	including
T6890	28755-28763	VBG	denotes	floating
T6892	28764-28772	JJ	denotes	synaptic
T6891	28773-28780	NNS	denotes	ribbons
T6893	28780-28782	,	denotes	,
T6894	28782-28784	IN	denotes	as
T6895	28785-28789	VBN	denotes	seen
T6896	28790-28794	RB	denotes	here
T6897	28794-28795	.	denotes	.
T6898	28795-28907	sentence	denotes	The mechanistic relationship of these two molecules, if any, in photoreceptor morphogenesis is unknown to date.
T6899	28796-28799	DT	denotes	The
T6901	28800-28811	JJ	denotes	mechanistic
T6900	28812-28824	NN	denotes	relationship
T6903	28825-28827	IN	denotes	of
T6904	28828-28833	DT	denotes	these
T6906	28834-28837	CD	denotes	two
T6905	28838-28847	NNS	denotes	molecules
T6907	28847-28849	,	denotes	,
T6909	28849-28851	IN	denotes	if
T6908	28852-28855	DT	denotes	any
T6910	28855-28857	,	denotes	,
T6911	28857-28859	IN	denotes	in
T6912	28860-28873	NN	denotes	photoreceptor
T6913	28874-28887	NN	denotes	morphogenesis
T6902	28888-28890	VBZ	denotes	is
T6914	28891-28898	JJ	denotes	unknown
T6915	28899-28901	IN	denotes	to
T6916	28902-28906	NN	denotes	date
T6917	28906-28907	.	denotes	.
T6918	28907-29105	sentence	denotes	The mRNA for laminin beta2 was not detected in the SAGE study of the relative RNA levels in Crx-/- and Crx+/+ and thus we cannot comment on whether the levels of RNA for laminin beta2 were altered.
T6919	28908-28911	DT	denotes	The
T6920	28912-28916	NN	denotes	mRNA
T6922	28917-28920	IN	denotes	for
T6923	28921-28928	NN	denotes	laminin
T6924	28929-28934	NN	denotes	beta2
T6925	28935-28938	VBD	denotes	was
T6926	28939-28942	RB	denotes	not
T6921	28943-28951	VBN	denotes	detected
T6927	28952-28954	IN	denotes	in
T6928	28955-28958	DT	denotes	the
T6930	28959-28963	NN	denotes	SAGE
T6929	28964-28969	NN	denotes	study
T6931	28970-28972	IN	denotes	of
T6932	28973-28976	DT	denotes	the
T6934	28977-28985	JJ	denotes	relative
T6935	28986-28989	NN	denotes	RNA
T6933	28990-28996	NNS	denotes	levels
T6936	28997-28999	IN	denotes	in
T6937	29000-29003	NN	denotes	Crx
T6938	29003-29004	SYM	denotes	-
T6939	29004-29005	HYPH	denotes	/
T6940	29005-29006	SYM	denotes	-
T6941	29007-29010	CC	denotes	and
T6942	29011-29014	NN	denotes	Crx
T6943	29014-29015	SYM	denotes	+
T6944	29015-29016	HYPH	denotes	/
T6945	29016-29017	SYM	denotes	+
T6946	29018-29021	CC	denotes	and
T6947	29022-29026	RB	denotes	thus
T6949	29027-29029	PRP	denotes	we
T6950	29030-29033	MD	denotes	can
T6951	29033-29036	RB	denotes	not
T6948	29037-29044	VB	denotes	comment
T6952	29045-29047	IN	denotes	on
T6953	29048-29055	IN	denotes	whether
T6955	29056-29059	DT	denotes	the
T6956	29060-29066	NNS	denotes	levels
T6957	29067-29069	IN	denotes	of
T6958	29070-29073	NN	denotes	RNA
T6959	29074-29077	IN	denotes	for
T6960	29078-29085	NN	denotes	laminin
T6961	29086-29091	NN	denotes	beta2
T6962	29092-29096	VBD	denotes	were
T6954	29097-29104	VBN	denotes	altered
T6963	29104-29105	.	denotes	.
T7157	29107-29110	NN	denotes	Crx
T7159	29110-29111	SYM	denotes	-
T7160	29111-29112	HYPH	denotes	/
T7161	29112-29113	SYM	denotes	-
T7158	29114-29118	NNS	denotes	mice
T7162	29119-29122	VBP	denotes	are
T7163	29123-29124	DT	denotes	a
T7164	29125-29130	NN	denotes	model
T7165	29131-29134	IN	denotes	for
T7166	29135-29138	NN	denotes	LCA
T7167	29138-29326	sentence	denotes	Crx has been implicated in three photoreceptor diseases that result in human blindness, cone-rod dystrophy2, Leber's congenital amaurosis, and retinitis pigmentosa (for review, see [53]).
T7168	29139-29142	NN	denotes	Crx
T7170	29143-29146	VBZ	denotes	has
T7171	29147-29151	VBN	denotes	been
T7169	29152-29162	VBN	denotes	implicated
T7172	29163-29165	IN	denotes	in
T7173	29166-29171	CD	denotes	three
T7175	29172-29185	NN	denotes	photoreceptor
T7174	29186-29194	NNS	denotes	diseases
T7176	29195-29199	WDT	denotes	that
T7177	29200-29206	VBP	denotes	result
T7178	29207-29209	IN	denotes	in
T7179	29210-29215	JJ	denotes	human
T7180	29216-29225	NN	denotes	blindness
T7181	29225-29227	,	denotes	,
T7182	29227-29231	NN	denotes	cone
T7184	29231-29232	HYPH	denotes	-
T7183	29232-29235	NN	denotes	rod
T7185	29236-29246	NN	denotes	dystrophy2
T7186	29246-29248	,	denotes	,
T7187	29248-29253	NNP	denotes	Leber
T7189	29253-29255	POS	denotes	's
T7190	29256-29266	JJ	denotes	congenital
T7188	29267-29276	NN	denotes	amaurosis
T7191	29276-29278	,	denotes	,
T7192	29278-29281	CC	denotes	and
T7193	29282-29291	NN	denotes	retinitis
T7194	29292-29302	NN	denotes	pigmentosa
T7195	29303-29304	-LRB-	denotes	(
T7197	29304-29307	IN	denotes	for
T7198	29308-29314	NN	denotes	review
T7199	29314-29316	,	denotes	,
T7196	29316-29319	VB	denotes	see
T7200	29320-29321	-LRB-	denotes	[
T7201	29321-29323	CD	denotes	53
T7202	29323-29324	-RRB-	denotes	]
T7203	29324-29325	-RRB-	denotes	)
T7204	29325-29326	.	denotes	.
T7205	29326-29511	sentence	denotes	The cone-rod dystrophies (CRDs) are characterized by loss of cone-mediated vision in the first decade of life or later, with concomitant or subsequent loss of rod-mediated vision [54].
T7206	29327-29330	DT	denotes	The
T7208	29331-29335	NN	denotes	cone
T7210	29335-29336	HYPH	denotes	-
T7209	29336-29339	NN	denotes	rod
T7207	29340-29351	NNS	denotes	dystrophies
T7212	29352-29353	-LRB-	denotes	(
T7213	29353-29357	NNS	denotes	CRDs
T7214	29357-29358	-RRB-	denotes	)
T7215	29359-29362	VBP	denotes	are
T7211	29363-29376	VBN	denotes	characterized
T7216	29377-29379	IN	denotes	by
T7217	29380-29384	NN	denotes	loss
T7218	29385-29387	IN	denotes	of
T7219	29388-29392	NN	denotes	cone
T7221	29392-29393	HYPH	denotes	-
T7220	29393-29401	VBN	denotes	mediated
T7222	29402-29408	NN	denotes	vision
T7223	29409-29411	IN	denotes	in
T7224	29412-29415	DT	denotes	the
T7226	29416-29421	JJ	denotes	first
T7225	29422-29428	NN	denotes	decade
T7227	29429-29431	IN	denotes	of
T7228	29432-29436	NN	denotes	life
T7229	29437-29439	CC	denotes	or
T7230	29440-29445	RB	denotes	later
T7232	29445-29447	,	denotes	,
T7231	29447-29451	IN	denotes	with
T7233	29452-29463	JJ	denotes	concomitant
T7235	29464-29466	CC	denotes	or
T7236	29467-29477	JJ	denotes	subsequent
T7234	29478-29482	NN	denotes	loss
T7237	29483-29485	IN	denotes	of
T7238	29486-29489	NN	denotes	rod
T7240	29489-29490	HYPH	denotes	-
T7239	29490-29498	VBN	denotes	mediated
T7241	29499-29505	NN	denotes	vision
T7242	29506-29507	-LRB-	denotes	[
T7243	29507-29509	CD	denotes	54
T7244	29509-29510	-RRB-	denotes	]
T7245	29510-29511	.	denotes	.
T7246	29511-29618	sentence	denotes	Conversely, RP is notable for initial loss of rod function, followed by loss of cone-mediated vision [55].
T7247	29512-29522	RB	denotes	Conversely
T7249	29522-29524	,	denotes	,
T7250	29524-29526	NN	denotes	RP
T7248	29527-29529	VBZ	denotes	is
T7251	29530-29537	JJ	denotes	notable
T7252	29538-29541	IN	denotes	for
T7253	29542-29549	JJ	denotes	initial
T7254	29550-29554	NN	denotes	loss
T7255	29555-29557	IN	denotes	of
T7256	29558-29561	NN	denotes	rod
T7257	29562-29570	NN	denotes	function
T7258	29570-29572	,	denotes	,
T7259	29572-29580	VBN	denotes	followed
T7260	29581-29583	IN	denotes	by
T7261	29584-29588	NN	denotes	loss
T7262	29589-29591	IN	denotes	of
T7263	29592-29596	NN	denotes	cone
T7265	29596-29597	HYPH	denotes	-
T7264	29597-29605	VBN	denotes	mediated
T7266	29606-29612	NN	denotes	vision
T7267	29613-29614	-LRB-	denotes	[
T7268	29614-29616	CD	denotes	55
T7269	29616-29617	-RRB-	denotes	]
T7270	29617-29618	.	denotes	.
T7271	29618-29808	sentence	denotes	The majority of known genes responsible for human genetic blindness, encode proteins expressed almost exclusively, or exclusively, in photoreceptors, particularly in the outer segment [35].
T7272	29619-29622	DT	denotes	The
T7273	29623-29631	NN	denotes	majority
T7275	29632-29634	IN	denotes	of
T7276	29635-29640	JJ	denotes	known
T7277	29641-29646	NNS	denotes	genes
T7278	29647-29658	JJ	denotes	responsible
T7279	29659-29662	IN	denotes	for
T7280	29663-29668	JJ	denotes	human
T7282	29669-29676	JJ	denotes	genetic
T7281	29677-29686	NN	denotes	blindness
T7283	29686-29688	,	denotes	,
T7274	29688-29694	VBP	denotes	encode
T7284	29695-29703	NN	denotes	proteins
T7285	29704-29713	VBN	denotes	expressed
T7286	29714-29720	RB	denotes	almost
T7287	29721-29732	RB	denotes	exclusively
T7289	29732-29734	,	denotes	,
T7290	29734-29736	CC	denotes	or
T7291	29737-29748	RB	denotes	exclusively
T7292	29748-29750	,	denotes	,
T7288	29750-29752	IN	denotes	in
T7293	29753-29767	NNS	denotes	photoreceptors
T7294	29767-29769	,	denotes	,
T7295	29769-29781	RB	denotes	particularly
T7296	29782-29784	IN	denotes	in
T7297	29785-29788	DT	denotes	the
T7299	29789-29794	JJ	denotes	outer
T7298	29795-29802	NN	denotes	segment
T7300	29803-29804	-LRB-	denotes	[
T7301	29804-29806	CD	denotes	35
T7302	29806-29807	-RRB-	denotes	]
T7303	29807-29808	.	denotes	.
T7304	29808-29894	sentence	denotes	Many of these proteins are required for phototransduction or outer segment structure.
T7305	29809-29813	JJ	denotes	Many
T7307	29814-29816	IN	denotes	of
T7308	29817-29822	DT	denotes	these
T7309	29823-29831	NN	denotes	proteins
T7310	29832-29835	VBP	denotes	are
T7306	29836-29844	VBN	denotes	required
T7311	29845-29848	IN	denotes	for
T7312	29849-29866	NN	denotes	phototransduction
T7313	29867-29869	CC	denotes	or
T7314	29870-29875	JJ	denotes	outer
T7315	29876-29883	NN	denotes	segment
T7316	29884-29893	NN	denotes	structure
T7317	29893-29894	.	denotes	.
T7318	29894-30028	sentence	denotes	The mechanisms whereby mutations in rod-specific genes, such as rhodopsin, lead eventually to cone degeneration in RP remain obscure.
T7319	29895-29898	DT	denotes	The
T7320	29899-29909	NNS	denotes	mechanisms
T7322	29910-29917	WRB	denotes	whereby
T7324	29918-29927	NNS	denotes	mutations
T7325	29928-29930	IN	denotes	in
T7326	29931-29934	NN	denotes	rod
T7328	29934-29935	HYPH	denotes	-
T7327	29935-29943	JJ	denotes	specific
T7329	29944-29949	NNS	denotes	genes
T7330	29949-29951	,	denotes	,
T7331	29951-29955	JJ	denotes	such
T7332	29956-29958	IN	denotes	as
T7333	29959-29968	NN	denotes	rhodopsin
T7334	29968-29970	,	denotes	,
T7323	29970-29974	VBP	denotes	lead
T7335	29975-29985	RB	denotes	eventually
T7336	29986-29988	IN	denotes	to
T7337	29989-29993	NN	denotes	cone
T7338	29994-30006	NN	denotes	degeneration
T7339	30007-30009	IN	denotes	in
T7340	30010-30012	NN	denotes	RP
T7321	30013-30019	VBP	denotes	remain
T7341	30020-30027	JJ	denotes	obscure
T7342	30027-30028	.	denotes	.
T7343	30028-30167	sentence	denotes	Mutations in Crx were the first, and still one of a very few examples of a transcription factor mutation leading to photoreceptor disease.
T7344	30029-30038	NNS	denotes	Mutations
T7346	30039-30041	IN	denotes	in
T7347	30042-30045	NN	denotes	Crx
T7345	30046-30050	VBD	denotes	were
T7348	30051-30054	DT	denotes	the
T7349	30055-30060	JJ	denotes	first
T7350	30060-30062	,	denotes	,
T7351	30062-30065	CC	denotes	and
T7352	30066-30071	RB	denotes	still
T7353	30072-30075	CD	denotes	one
T7355	30076-30078	IN	denotes	of
T7356	30079-30080	DT	denotes	a
T7358	30081-30085	RB	denotes	very
T7357	30086-30089	JJ	denotes	few
T7354	30090-30098	NNS	denotes	examples
T7359	30099-30101	IN	denotes	of
T7360	30102-30103	DT	denotes	a
T7362	30104-30117	NN	denotes	transcription
T7363	30118-30124	NN	denotes	factor
T7361	30125-30133	NN	denotes	mutation
T7364	30134-30141	VBG	denotes	leading
T7365	30142-30144	IN	denotes	to
T7366	30145-30158	NN	denotes	photoreceptor
T7367	30159-30166	NN	denotes	disease
T7368	30166-30167	.	denotes	.
T7369	30167-30314	sentence	denotes	LCA is a disease in which there is little or no photoreceptor function in infancy; thereby, likely developmental in etiology ([17,56] for review).
T7370	30168-30171	NN	denotes	LCA
T7371	30172-30174	VBZ	denotes	is
T7372	30175-30176	DT	denotes	a
T7373	30177-30184	NN	denotes	disease
T7374	30185-30187	IN	denotes	in
T7376	30188-30193	WDT	denotes	which
T7377	30194-30199	EX	denotes	there
T7375	30200-30202	VBZ	denotes	is
T7378	30203-30209	JJ	denotes	little
T7380	30210-30212	CC	denotes	or
T7381	30213-30215	DT	denotes	no
T7382	30216-30229	NN	denotes	photoreceptor
T7379	30230-30238	NN	denotes	function
T7383	30239-30241	IN	denotes	in
T7384	30242-30249	NN	denotes	infancy
T7385	30249-30250	:	denotes	;
T7386	30251-30258	RB	denotes	thereby
T7388	30258-30260	,	denotes	,
T7389	30260-30266	RB	denotes	likely
T7387	30267-30280	JJ	denotes	developmental
T7390	30281-30283	IN	denotes	in
T7391	30284-30292	NN	denotes	etiology
T7392	30293-30294	-LRB-	denotes	(
T7394	30294-30295	-LRB-	denotes	[
T7395	30295-30297	CD	denotes	17
T7396	30297-30298	,	denotes	,
T7393	30298-30300	CD	denotes	56
T7397	30300-30301	-RRB-	denotes	]
T7398	30302-30305	IN	denotes	for
T7399	30306-30312	NN	denotes	review
T7400	30312-30313	-RRB-	denotes	)
T7401	30313-30314	.	denotes	.
T7402	30314-30477	sentence	denotes	The Crx-/- mouse may be an excellent model for studying the pathology of this disorder, particularly the subtype of the disorder where Crx mutations are involved.
T7403	30315-30318	DT	denotes	The
T7405	30319-30322	NN	denotes	Crx
T7406	30322-30323	SYM	denotes	-
T7407	30323-30324	HYPH	denotes	/
T7408	30324-30325	SYM	denotes	-
T7404	30326-30331	NN	denotes	mouse
T7410	30332-30335	MD	denotes	may
T7409	30336-30338	VB	denotes	be
T7411	30339-30341	DT	denotes	an
T7413	30342-30351	JJ	denotes	excellent
T7412	30352-30357	NN	denotes	model
T7414	30358-30361	IN	denotes	for
T7415	30362-30370	VBG	denotes	studying
T7416	30371-30374	DT	denotes	the
T7417	30375-30384	NN	denotes	pathology
T7418	30385-30387	IN	denotes	of
T7419	30388-30392	DT	denotes	this
T7420	30393-30401	NN	denotes	disorder
T7421	30401-30403	,	denotes	,
T7422	30403-30415	RB	denotes	particularly
T7424	30416-30419	DT	denotes	the
T7423	30420-30427	NN	denotes	subtype
T7425	30428-30430	IN	denotes	of
T7426	30431-30434	DT	denotes	the
T7427	30435-30443	NN	denotes	disorder
T7428	30444-30449	WRB	denotes	where
T7430	30450-30453	NN	denotes	Crx
T7431	30454-30463	NNS	denotes	mutations
T7432	30464-30467	VBP	denotes	are
T7429	30468-30476	VBN	denotes	involved
T7433	30476-30477	.	denotes	.
T7434	30477-30644	sentence	denotes	The vast majority of histopathological studies of LCA in human tissue have been derived from adult patients with LCA where secondary changes are likely to be present.
T7435	30478-30481	DT	denotes	The
T7437	30482-30486	JJ	denotes	vast
T7436	30487-30495	NN	denotes	majority
T7439	30496-30498	IN	denotes	of
T7440	30499-30516	JJ	denotes	histopathological
T7441	30517-30524	NNS	denotes	studies
T7442	30525-30527	IN	denotes	of
T7443	30528-30531	NN	denotes	LCA
T7444	30532-30534	IN	denotes	in
T7445	30535-30540	JJ	denotes	human
T7446	30541-30547	NN	denotes	tissue
T7447	30548-30552	VBP	denotes	have
T7448	30553-30557	VBN	denotes	been
T7438	30558-30565	VBN	denotes	derived
T7449	30566-30570	IN	denotes	from
T7450	30571-30576	JJ	denotes	adult
T7451	30577-30585	NNS	denotes	patients
T7452	30586-30590	IN	denotes	with
T7453	30591-30594	NN	denotes	LCA
T7454	30595-30600	WRB	denotes	where
T7456	30601-30610	JJ	denotes	secondary
T7457	30611-30618	NNS	denotes	changes
T7455	30619-30622	VBP	denotes	are
T7458	30623-30629	JJ	denotes	likely
T7459	30630-30632	TO	denotes	to
T7460	30633-30635	VB	denotes	be
T7461	30636-30643	JJ	denotes	present
T7462	30643-30644	.	denotes	.
T7463	30644-30788	sentence	denotes	Indeed in animal models of LCA, secondary reactive and/or degenerative changes occur early after the abnormal formation of retinal tissue [57].
T7464	30645-30651	RB	denotes	Indeed
T7466	30652-30654	IN	denotes	in
T7467	30655-30661	NN	denotes	animal
T7468	30662-30668	NNS	denotes	models
T7469	30669-30671	IN	denotes	of
T7470	30672-30675	NN	denotes	LCA
T7471	30675-30677	,	denotes	,
T7472	30677-30686	JJ	denotes	secondary
T7474	30687-30695	JJ	denotes	reactive
T7475	30696-30699	CC	denotes	and
T7476	30699-30700	HYPH	denotes	/
T7477	30700-30702	CC	denotes	or
T7478	30703-30715	JJ	denotes	degenerative
T7473	30716-30723	NNS	denotes	changes
T7465	30724-30729	VBP	denotes	occur
T7479	30730-30735	RB	denotes	early
T7480	30736-30741	IN	denotes	after
T7481	30742-30745	DT	denotes	the
T7483	30746-30754	JJ	denotes	abnormal
T7482	30755-30764	NN	denotes	formation
T7484	30765-30767	IN	denotes	of
T7485	30768-30775	JJ	denotes	retinal
T7486	30776-30782	NN	denotes	tissue
T7487	30783-30784	-LRB-	denotes	[
T7488	30784-30786	CD	denotes	57
T7489	30786-30787	-RRB-	denotes	]
T7490	30787-30788	.	denotes	.
T7491	30788-30949	sentence	denotes	The only study in human tissue derived from a human 33-week retina with proposed RPE65 mutations was reported to have abnormal retinae at this early stage [24].
T7492	30789-30792	DT	denotes	The
T7494	30793-30797	JJ	denotes	only
T7493	30798-30803	NN	denotes	study
T7496	30804-30806	IN	denotes	in
T7497	30807-30812	JJ	denotes	human
T7498	30813-30819	NN	denotes	tissue
T7499	30820-30827	VBN	denotes	derived
T7500	30828-30832	IN	denotes	from
T7501	30833-30834	DT	denotes	a
T7503	30835-30840	JJ	denotes	human
T7504	30841-30843	CD	denotes	33
T7506	30843-30844	HYPH	denotes	-
T7505	30844-30848	NN	denotes	week
T7502	30849-30855	NN	denotes	retina
T7507	30856-30860	IN	denotes	with
T7508	30861-30869	VBN	denotes	proposed
T7510	30870-30875	NN	denotes	RPE65
T7509	30876-30885	NNS	denotes	mutations
T7511	30886-30889	VBD	denotes	was
T7495	30890-30898	VBN	denotes	reported
T7512	30899-30901	TO	denotes	to
T7513	30902-30906	VB	denotes	have
T7514	30907-30915	JJ	denotes	abnormal
T7515	30916-30923	NNS	denotes	retinae
T7516	30924-30926	IN	denotes	at
T7517	30927-30931	DT	denotes	this
T7519	30932-30937	JJ	denotes	early
T7518	30938-30943	NN	denotes	stage
T7520	30944-30945	-LRB-	denotes	[
T7521	30945-30947	CD	denotes	24
T7522	30947-30948	-RRB-	denotes	]
T7523	30948-30949	.	denotes	.
T7524	30949-31028	sentence	denotes	These authors report cell loss, including thinning of the photoreceptor layer.
T7525	30950-30955	DT	denotes	These
T7526	30956-30963	NNS	denotes	authors
T7527	30964-30970	VBP	denotes	report
T7528	30971-30975	NN	denotes	cell
T7529	30976-30980	NN	denotes	loss
T7530	30980-30982	,	denotes	,
T7531	30982-30991	VBG	denotes	including
T7532	30992-31000	NN	denotes	thinning
T7533	31001-31003	IN	denotes	of
T7534	31004-31007	DT	denotes	the
T7536	31008-31021	NN	denotes	photoreceptor
T7535	31022-31027	NN	denotes	layer
T7537	31027-31028	.	denotes	.
T7538	31028-31246	sentence	denotes	In addition, they claim in the text to have seen aberrant synaptic and inner retinal organization, although their examination of photoreceptor synapses unfortunately are not presented in the data section of the paper.
T7539	31029-31031	IN	denotes	In
T7541	31032-31040	NN	denotes	addition
T7542	31040-31042	,	denotes	,
T7543	31042-31046	PRP	denotes	they
T7540	31047-31052	VBP	denotes	claim
T7544	31053-31055	IN	denotes	in
T7545	31056-31059	DT	denotes	the
T7546	31060-31064	NN	denotes	text
T7547	31065-31067	TO	denotes	to
T7549	31068-31072	VB	denotes	have
T7548	31073-31077	VBN	denotes	seen
T7550	31078-31086	JJ	denotes	aberrant
T7552	31087-31095	JJ	denotes	synaptic
T7553	31096-31099	CC	denotes	and
T7554	31100-31105	JJ	denotes	inner
T7555	31106-31113	JJ	denotes	retinal
T7551	31114-31126	NN	denotes	organization
T7556	31126-31128	,	denotes	,
T7557	31128-31136	IN	denotes	although
T7559	31137-31142	PRP$	denotes	their
T7560	31143-31154	NN	denotes	examination
T7561	31155-31157	IN	denotes	of
T7562	31158-31171	NN	denotes	photoreceptor
T7563	31172-31180	NNS	denotes	synapses
T7564	31181-31194	RB	denotes	unfortunately
T7565	31195-31198	VBP	denotes	are
T7566	31199-31202	RB	denotes	not
T7558	31203-31212	VBN	denotes	presented
T7567	31213-31215	IN	denotes	in
T7568	31216-31219	DT	denotes	the
T7570	31220-31224	NNS	denotes	data
T7569	31225-31232	NN	denotes	section
T7571	31233-31235	IN	denotes	of
T7572	31236-31239	DT	denotes	the
T7573	31240-31245	NN	denotes	paper
T7574	31245-31246	.	denotes	.
T7575	31246-31373	sentence	denotes	Given the scarcity of available human tissue, the characterization of the primary pathology of LCA will require animal models.
T7576	31247-31252	VBN	denotes	Given
T7578	31253-31256	DT	denotes	the
T7579	31257-31265	NN	denotes	scarcity
T7580	31266-31268	IN	denotes	of
T7581	31269-31278	JJ	denotes	available
T7583	31279-31284	JJ	denotes	human
T7582	31285-31291	NN	denotes	tissue
T7584	31291-31293	,	denotes	,
T7585	31293-31296	DT	denotes	the
T7586	31297-31313	NN	denotes	characterization
T7587	31314-31316	IN	denotes	of
T7588	31317-31320	DT	denotes	the
T7590	31321-31328	JJ	denotes	primary
T7589	31329-31338	NN	denotes	pathology
T7591	31339-31341	IN	denotes	of
T7592	31342-31345	NN	denotes	LCA
T7593	31346-31350	MD	denotes	will
T7577	31351-31358	VB	denotes	require
T7594	31359-31365	NN	denotes	animal
T7595	31366-31372	NNS	denotes	models
T7596	31372-31373	.	denotes	.
T7597	31373-31548	sentence	denotes	In the current study, we present data that argue that, in addition to outer segment morphogenesis, synaptogenesis may also be critically impaired in at least a subset of LCA.
T7598	31374-31376	IN	denotes	In
T7600	31377-31380	DT	denotes	the
T7602	31381-31388	JJ	denotes	current
T7601	31389-31394	NN	denotes	study
T7603	31394-31396	,	denotes	,
T7604	31396-31398	PRP	denotes	we
T7599	31399-31406	VBP	denotes	present
T7605	31407-31411	NNS	denotes	data
T7606	31412-31416	WDT	denotes	that
T7607	31417-31422	VBP	denotes	argue
T7608	31423-31427	IN	denotes	that
T7610	31427-31429	,	denotes	,
T7611	31429-31431	IN	denotes	in
T7612	31432-31440	NN	denotes	addition
T7613	31441-31443	IN	denotes	to
T7614	31444-31449	JJ	denotes	outer
T7615	31450-31457	NN	denotes	segment
T7616	31458-31471	NN	denotes	morphogenesis
T7617	31471-31473	,	denotes	,
T7618	31473-31487	NN	denotes	synaptogenesis
T7619	31488-31491	MD	denotes	may
T7620	31492-31496	RB	denotes	also
T7609	31497-31499	VB	denotes	be
T7621	31500-31510	RB	denotes	critically
T7622	31511-31519	JJ	denotes	impaired
T7623	31520-31522	IN	denotes	in
T7624	31523-31525	RB	denotes	at
T7626	31526-31531	RBS	denotes	least
T7625	31532-31533	DT	denotes	a
T7627	31534-31540	NN	denotes	subset
T7628	31541-31543	IN	denotes	of
T7629	31544-31547	NN	denotes	LCA
T7630	31547-31548	.	denotes	.
T7656	31559-31563	NNS	denotes	Mice
T7657	31563-31618	sentence	denotes	Crx-/- mice were generated as reported elsewhere [34].
T7658	31564-31567	NN	denotes	Crx
T7660	31567-31568	SYM	denotes	-
T7661	31568-31569	HYPH	denotes	/
T7662	31569-31570	SYM	denotes	-
T7659	31571-31575	NNS	denotes	mice
T7664	31576-31580	VBD	denotes	were
T7663	31581-31590	VBN	denotes	generated
T7665	31591-31593	IN	denotes	as
T7666	31594-31602	VBN	denotes	reported
T7667	31603-31612	RB	denotes	elsewhere
T7668	31613-31614	-LRB-	denotes	[
T7669	31614-31616	CD	denotes	34
T7670	31616-31617	-RRB-	denotes	]
T7671	31617-31618	.	denotes	.
T7672	31618-31700	sentence	denotes	Rhodosin-null mice [29] were obtained from Paul Sieving (University of Michigan).
T7673	31619-31627	NN	denotes	Rhodosin
T7675	31627-31628	HYPH	denotes	-
T7674	31628-31632	JJ	denotes	null
T7676	31633-31637	NNS	denotes	mice
T7678	31638-31639	-LRB-	denotes	[
T7679	31639-31641	CD	denotes	29
T7680	31641-31642	-RRB-	denotes	]
T7681	31643-31647	VBD	denotes	were
T7677	31648-31656	VBN	denotes	obtained
T7682	31657-31661	IN	denotes	from
T7683	31662-31666	NNP	denotes	Paul
T7684	31667-31674	NNP	denotes	Sieving
T7685	31675-31676	-LRB-	denotes	(
T7686	31676-31686	NNP	denotes	University
T7687	31687-31689	IN	denotes	of
T7688	31690-31698	NNP	denotes	Michigan
T7689	31698-31699	-RRB-	denotes	)
T7690	31699-31700	.	denotes	.
T7691	31700-31748	sentence	denotes	Rds mice were acquired from Jackson Laboratory.
T7692	31701-31704	NN	denotes	Rds
T7693	31705-31709	NNS	denotes	mice
T7695	31710-31714	VBD	denotes	were
T7694	31715-31723	VBN	denotes	acquired
T7696	31724-31728	IN	denotes	from
T7697	31729-31736	NNP	denotes	Jackson
T7698	31737-31747	NNP	denotes	Laboratory
T7699	31747-31748	.	denotes	.
T7779	31750-31762	NN	denotes	Transmission
T7781	31763-31771	NN	denotes	electron
T7780	31772-31782	NN	denotes	microscopy
T7782	31782-31904	sentence	denotes	Littermate Crx-/- and wildtype pups were perfused in 1% formaldehyde and 0.5% glutaraldehyde at various postnatal stages.
T7783	31783-31793	NN	denotes	Littermate
T7785	31794-31797	NN	denotes	Crx
T7786	31797-31798	SYM	denotes	-
T7787	31798-31799	HYPH	denotes	/
T7788	31799-31800	SYM	denotes	-
T7789	31801-31804	CC	denotes	and
T7790	31805-31813	JJ	denotes	wildtype
T7784	31814-31818	NNS	denotes	pups
T7792	31819-31823	VBD	denotes	were
T7791	31824-31832	VBN	denotes	perfused
T7793	31833-31835	IN	denotes	in
T7794	31836-31837	CD	denotes	1
T7795	31837-31838	NN	denotes	%
T7796	31839-31851	NN	denotes	formaldehyde
T7797	31852-31855	CC	denotes	and
T7798	31856-31859	CD	denotes	0.5
T7799	31859-31860	NN	denotes	%
T7800	31861-31875	NN	denotes	glutaraldehyde
T7801	31876-31878	IN	denotes	at
T7802	31879-31886	JJ	denotes	various
T7804	31887-31896	JJ	denotes	postnatal
T7803	31897-31903	NNS	denotes	stages
T7805	31903-31904	.	denotes	.
T7806	31904-31973	sentence	denotes	The eyes were then enucleated, and the cornea and lens were removed.
T7807	31905-31908	DT	denotes	The
T7808	31909-31913	NNS	denotes	eyes
T7810	31914-31918	VBD	denotes	were
T7811	31919-31923	RB	denotes	then
T7809	31924-31934	VBN	denotes	enucleated
T7812	31934-31936	,	denotes	,
T7813	31936-31939	CC	denotes	and
T7814	31940-31943	DT	denotes	the
T7815	31944-31950	NN	denotes	cornea
T7817	31951-31954	CC	denotes	and
T7818	31955-31959	NN	denotes	lens
T7819	31960-31964	VBD	denotes	were
T7816	31965-31972	VBN	denotes	removed
T7820	31972-31973	.	denotes	.
T7821	31973-32077	sentence	denotes	The eye cup was immersed in fixative (1% formaldehyde and 2.5% glutaraldehyde) for 3 to 4 hours at 4°C.
T7822	31974-31977	DT	denotes	The
T7824	31978-31981	NN	denotes	eye
T7823	31982-31985	NN	denotes	cup
T7826	31986-31989	VBD	denotes	was
T7825	31990-31998	VBN	denotes	immersed
T7827	31999-32001	IN	denotes	in
T7828	32002-32010	NN	denotes	fixative
T7829	32011-32012	-LRB-	denotes	(
T7830	32012-32013	CD	denotes	1
T7831	32013-32014	NN	denotes	%
T7832	32015-32027	NN	denotes	formaldehyde
T7833	32028-32031	CC	denotes	and
T7834	32032-32035	CD	denotes	2.5
T7835	32035-32036	NN	denotes	%
T7836	32037-32051	NN	denotes	glutaraldehyde
T7837	32051-32052	-RRB-	denotes	)
T7838	32053-32056	IN	denotes	for
T7839	32057-32058	CD	denotes	3
T7841	32059-32061	IN	denotes	to
T7840	32062-32063	CD	denotes	4
T7842	32064-32069	NNS	denotes	hours
T7843	32070-32072	IN	denotes	at
T7844	32073-32074	CD	denotes	4
T7845	32074-32076	NN	denotes	°C
T7846	32076-32077	.	denotes	.
T7847	32077-32235	sentence	denotes	The sclera was then partially removed and the retinas were sliced into small pieces and fixed (1% paraformaldehyde and 2.5% glutaraldehyde) overnight at 4°C.
T7848	32078-32081	DT	denotes	The
T7849	32082-32088	NN	denotes	sclera
T7851	32089-32092	VBD	denotes	was
T7852	32093-32097	RB	denotes	then
T7853	32098-32107	RB	denotes	partially
T7850	32108-32115	VBN	denotes	removed
T7854	32116-32119	CC	denotes	and
T7855	32120-32123	DT	denotes	the
T7856	32124-32131	NNS	denotes	retinas
T7858	32132-32136	VBD	denotes	were
T7857	32137-32143	VBN	denotes	sliced
T7859	32144-32148	IN	denotes	into
T7860	32149-32154	JJ	denotes	small
T7861	32155-32161	NNS	denotes	pieces
T7862	32162-32165	CC	denotes	and
T7863	32166-32171	VBN	denotes	fixed
T7864	32172-32173	-LRB-	denotes	(
T7866	32173-32174	CD	denotes	1
T7867	32174-32175	NN	denotes	%
T7865	32176-32192	NN	denotes	paraformaldehyde
T7868	32193-32196	CC	denotes	and
T7869	32197-32200	CD	denotes	2.5
T7870	32200-32201	NN	denotes	%
T7871	32202-32216	NN	denotes	glutaraldehyde
T7872	32216-32217	-RRB-	denotes	)
T7873	32218-32227	RB	denotes	overnight
T7874	32228-32230	IN	denotes	at
T7875	32231-32232	CD	denotes	4
T7876	32232-32234	NN	denotes	°C
T7877	32234-32235	.	denotes	.
T7878	32235-32349	sentence	denotes	These procedures were found optimal for maintaining the structural integrity of the photoreceptor outer segments.
T7879	32236-32241	DT	denotes	These
T7880	32242-32252	NNS	denotes	procedures
T7882	32253-32257	VBD	denotes	were
T7881	32258-32263	VBN	denotes	found
T7883	32264-32271	JJ	denotes	optimal
T7884	32272-32275	IN	denotes	for
T7885	32276-32287	VBG	denotes	maintaining
T7886	32288-32291	DT	denotes	the
T7888	32292-32302	JJ	denotes	structural
T7887	32303-32312	NN	denotes	integrity
T7889	32313-32315	IN	denotes	of
T7890	32316-32319	DT	denotes	the
T7892	32320-32333	NN	denotes	photoreceptor
T7893	32334-32339	JJ	denotes	outer
T7891	32340-32348	NNS	denotes	segments
T7894	32348-32349	.	denotes	.
T7895	32349-32424	sentence	denotes	After fixing, the tissue was washed 2X in PBS for thirty minutes per wash.
T7896	32350-32355	IN	denotes	After
T7898	32356-32362	NN	denotes	fixing
T7899	32362-32364	,	denotes	,
T7900	32364-32367	DT	denotes	the
T7901	32368-32374	NN	denotes	tissue
T7902	32375-32378	VBD	denotes	was
T7897	32379-32385	VBN	denotes	washed
T7903	32386-32387	CD	denotes	2
T7904	32387-32388	SYM	denotes	X
T7905	32389-32391	IN	denotes	in
T7906	32392-32395	NN	denotes	PBS
T7907	32396-32399	IN	denotes	for
T7908	32400-32406	CD	denotes	thirty
T7909	32407-32414	NNS	denotes	minutes
T7910	32415-32418	IN	denotes	per
T7911	32419-32423	NN	denotes	wash
T7912	32423-32424	.	denotes	.
T7913	32424-32535	sentence	denotes	The tissue was then postfixed in a 1% osmium tetroxide/1.5% potassium ferrocyanide mixture for 2 hours at 4°C.
T7914	32425-32428	DT	denotes	The
T7915	32429-32435	NN	denotes	tissue
T7917	32436-32439	VBD	denotes	was
T7918	32440-32444	RB	denotes	then
T7916	32445-32454	VBN	denotes	postfixed
T7919	32455-32457	IN	denotes	in
T7920	32458-32459	DT	denotes	a
T7922	32460-32461	CD	denotes	1
T7923	32461-32462	NN	denotes	%
T7925	32463-32469	NN	denotes	osmium
T7924	32470-32479	NN	denotes	tetroxide
T7926	32479-32480	HYPH	denotes	/
T7927	32480-32483	CD	denotes	1.5
T7928	32483-32484	NN	denotes	%
T7930	32485-32494	NN	denotes	potassium
T7929	32495-32507	NN	denotes	ferrocyanide
T7921	32508-32515	NN	denotes	mixture
T7931	32516-32519	IN	denotes	for
T7932	32520-32521	CD	denotes	2
T7933	32522-32527	NNS	denotes	hours
T7934	32528-32530	IN	denotes	at
T7935	32531-32532	CD	denotes	4
T7936	32532-32534	NN	denotes	°C
T7937	32534-32535	.	denotes	.
T7938	32535-32730	sentence	denotes	Staining was carried out for 30 minutes in 1% uranyl acetate in maleate buffer (pH = 6.0) at room temperature followed by 1% tannic acid in 0.1 M cacodylate buffer (pH = 7.4) for thirty minutes.
T7939	32536-32544	NN	denotes	Staining
T7941	32545-32548	VBD	denotes	was
T7940	32549-32556	VBN	denotes	carried
T7942	32557-32560	RP	denotes	out
T7943	32561-32564	IN	denotes	for
T7944	32565-32567	CD	denotes	30
T7945	32568-32575	NNS	denotes	minutes
T7946	32576-32578	IN	denotes	in
T7947	32579-32580	CD	denotes	1
T7948	32580-32581	NN	denotes	%
T7950	32582-32588	NN	denotes	uranyl
T7949	32589-32596	NN	denotes	acetate
T7951	32597-32599	IN	denotes	in
T7952	32600-32607	NN	denotes	maleate
T7953	32608-32614	NN	denotes	buffer
T7954	32615-32616	-LRB-	denotes	(
T7956	32616-32618	NN	denotes	pH
T7957	32619-32620	SYM	denotes	=
T7955	32621-32624	CD	denotes	6.0
T7958	32624-32625	-RRB-	denotes	)
T7959	32626-32628	IN	denotes	at
T7960	32629-32633	NN	denotes	room
T7961	32634-32645	NN	denotes	temperature
T7962	32646-32654	VBN	denotes	followed
T7963	32655-32657	IN	denotes	by
T7964	32658-32659	CD	denotes	1
T7965	32659-32660	NN	denotes	%
T7967	32661-32667	JJ	denotes	tannic
T7966	32668-32672	NN	denotes	acid
T7968	32673-32675	IN	denotes	in
T7969	32676-32679	CD	denotes	0.1
T7970	32680-32681	NN	denotes	M
T7972	32682-32692	NN	denotes	cacodylate
T7971	32693-32699	NN	denotes	buffer
T7973	32700-32701	-LRB-	denotes	(
T7975	32701-32703	NN	denotes	pH
T7976	32704-32705	SYM	denotes	=
T7974	32706-32709	CD	denotes	7.4
T7977	32709-32710	-RRB-	denotes	)
T7978	32711-32714	IN	denotes	for
T7979	32715-32721	CD	denotes	thirty
T7980	32722-32729	NNS	denotes	minutes
T7981	32729-32730	.	denotes	.
T7982	32730-32796	sentence	denotes	The specimens were then dehydrated and embedded in Epon/Araldite.
T7983	32731-32734	DT	denotes	The
T7984	32735-32744	NNS	denotes	specimens
T7986	32745-32749	VBD	denotes	were
T7987	32750-32754	RB	denotes	then
T7985	32755-32765	VBN	denotes	dehydrated
T7988	32766-32769	CC	denotes	and
T7989	32770-32778	VBN	denotes	embedded
T7990	32779-32781	IN	denotes	in
T7991	32782-32786	NN	denotes	Epon
T7993	32786-32787	HYPH	denotes	/
T7992	32787-32795	NN	denotes	Araldite
T7994	32795-32796	.	denotes	.
T7995	32796-32916	sentence	denotes	Thin sections were stained with uranyl acetate and lead citrate, and examined in a Jeol JEM-1200EX electron microscope.
T7996	32797-32801	JJ	denotes	Thin
T7997	32802-32810	NNS	denotes	sections
T7999	32811-32815	VBD	denotes	were
T7998	32816-32823	VBN	denotes	stained
T8000	32824-32828	IN	denotes	with
T8001	32829-32835	NN	denotes	uranyl
T8002	32836-32843	NN	denotes	acetate
T8003	32844-32847	CC	denotes	and
T8004	32848-32852	NN	denotes	lead
T8005	32853-32860	NN	denotes	citrate
T8006	32860-32862	,	denotes	,
T8007	32862-32865	CC	denotes	and
T8008	32866-32874	VBN	denotes	examined
T8009	32875-32877	IN	denotes	in
T8010	32878-32879	DT	denotes	a
T8012	32880-32884	NNP	denotes	Jeol
T8014	32885-32888	NNP	denotes	JEM
T8015	32888-32889	HYPH	denotes	-
T8013	32889-32895	NNP	denotes	1200EX
T8016	32896-32904	NN	denotes	electron
T8011	32905-32915	NN	denotes	microscope
T8017	32915-32916	.	denotes	.
T8072	32918-32926	VBG	denotes	Scanning
T8074	32927-32935	NN	denotes	electron
T8073	32936-32946	NN	denotes	microscopy
T8075	32946-33092	sentence	denotes	Specimens used for SEM required removal of the retinal pigment epithelium (PE), enabling visualization of the outer surface of the neural retina.
T8076	32947-32956	NNS	denotes	Specimens
T8078	32957-32961	VBN	denotes	used
T8079	32962-32965	IN	denotes	for
T8080	32966-32969	NN	denotes	SEM
T8077	32970-32978	VBD	denotes	required
T8081	32979-32986	NN	denotes	removal
T8082	32987-32989	IN	denotes	of
T8083	32990-32993	DT	denotes	the
T8085	32994-33001	JJ	denotes	retinal
T8086	33002-33009	NN	denotes	pigment
T8084	33010-33020	NN	denotes	epithelium
T8087	33021-33022	-LRB-	denotes	(
T8088	33022-33024	NN	denotes	PE
T8089	33024-33025	-RRB-	denotes	)
T8090	33025-33027	,	denotes	,
T8091	33027-33035	VBG	denotes	enabling
T8092	33036-33049	NN	denotes	visualization
T8093	33050-33052	IN	denotes	of
T8094	33053-33056	DT	denotes	the
T8096	33057-33062	JJ	denotes	outer
T8095	33063-33070	NN	denotes	surface
T8097	33071-33073	IN	denotes	of
T8098	33074-33077	DT	denotes	the
T8100	33078-33084	JJ	denotes	neural
T8099	33085-33091	NN	denotes	retina
T8101	33091-33092	.	denotes	.
T8102	33092-33273	sentence	denotes	Retinae from Crx-/-, rhodopsin-/-, RDS, or wildtype eyes were dissected free from PE in a dispase solution and fixed in 1.25% glutaraldehyde and 1.0% formaldehyde overnight at 4°C.
T8103	33093-33100	NNS	denotes	Retinae
T8105	33101-33105	IN	denotes	from
T8106	33106-33109	NN	denotes	Crx
T8108	33109-33110	SYM	denotes	-
T8109	33110-33111	HYPH	denotes	/
T8110	33111-33112	SYM	denotes	-
T8111	33112-33114	,	denotes	,
T8112	33114-33123	NN	denotes	rhodopsin
T8113	33123-33124	SYM	denotes	-
T8114	33124-33125	HYPH	denotes	/
T8115	33125-33126	SYM	denotes	-
T8116	33126-33128	,	denotes	,
T8117	33128-33131	NN	denotes	RDS
T8118	33131-33133	,	denotes	,
T8119	33133-33135	CC	denotes	or
T8120	33136-33144	NN	denotes	wildtype
T8107	33145-33149	NNS	denotes	eyes
T8121	33150-33154	VBD	denotes	were
T8104	33155-33164	VBN	denotes	dissected
T8122	33165-33169	JJ	denotes	free
T8123	33170-33174	IN	denotes	from
T8124	33175-33177	NN	denotes	PE
T8125	33178-33180	IN	denotes	in
T8126	33181-33182	DT	denotes	a
T8128	33183-33190	NN	denotes	dispase
T8127	33191-33199	NN	denotes	solution
T8129	33200-33203	CC	denotes	and
T8130	33204-33209	VBN	denotes	fixed
T8131	33210-33212	IN	denotes	in
T8132	33213-33217	CD	denotes	1.25
T8133	33217-33218	NN	denotes	%
T8134	33219-33233	NN	denotes	glutaraldehyde
T8135	33234-33237	CC	denotes	and
T8136	33238-33241	CD	denotes	1.0
T8137	33241-33242	NN	denotes	%
T8138	33243-33255	NN	denotes	formaldehyde
T8139	33256-33265	RB	denotes	overnight
T8140	33266-33268	IN	denotes	at
T8141	33269-33270	CD	denotes	4
T8142	33270-33272	NN	denotes	°C
T8143	33272-33273	.	denotes	.
T8144	33273-33367	sentence	denotes	Tissue was then washed 5X in cacodylate buffer and dehydrated in ascending grades of ethanol.
T8145	33274-33280	NN	denotes	Tissue
T8147	33281-33284	VBD	denotes	was
T8148	33285-33289	RB	denotes	then
T8146	33290-33296	VBN	denotes	washed
T8149	33297-33298	CD	denotes	5
T8150	33298-33299	SYM	denotes	X
T8151	33300-33302	IN	denotes	in
T8152	33303-33313	NN	denotes	cacodylate
T8153	33314-33320	NN	denotes	buffer
T8154	33321-33324	CC	denotes	and
T8155	33325-33335	VBN	denotes	dehydrated
T8156	33336-33338	IN	denotes	in
T8157	33339-33348	VBG	denotes	ascending
T8158	33349-33355	NNS	denotes	grades
T8159	33356-33358	IN	denotes	of
T8160	33359-33366	NN	denotes	ethanol
T8161	33366-33367	.	denotes	.
T8162	33367-33433	sentence	denotes	Tissues were subsequently critical point dried in carbon dioxide.
T8163	33368-33375	NNS	denotes	Tissues
T8165	33376-33380	VBD	denotes	were
T8166	33381-33393	RB	denotes	subsequently
T8167	33394-33402	JJ	denotes	critical
T8168	33403-33408	NN	denotes	point
T8164	33409-33414	VBN	denotes	dried
T8169	33415-33417	IN	denotes	in
T8170	33418-33424	NN	denotes	carbon
T8171	33425-33432	NN	denotes	dioxide
T8172	33432-33433	.	denotes	.
T8173	33433-33531	sentence	denotes	All specimens were mounted and coated with sublimated gold-palladium by the sputtering technique.
T8174	33434-33437	DT	denotes	All
T8175	33438-33447	NNS	denotes	specimens
T8177	33448-33452	VBD	denotes	were
T8176	33453-33460	VBN	denotes	mounted
T8178	33461-33464	CC	denotes	and
T8179	33465-33471	VBN	denotes	coated
T8180	33472-33476	IN	denotes	with
T8181	33477-33487	VBN	denotes	sublimated
T8183	33488-33492	NN	denotes	gold
T8184	33492-33493	HYPH	denotes	-
T8182	33493-33502	NN	denotes	palladium
T8185	33503-33505	IN	denotes	by
T8186	33506-33509	DT	denotes	the
T8188	33510-33520	NN	denotes	sputtering
T8187	33521-33530	NN	denotes	technique
T8189	33530-33531	.	denotes	.
T8190	33531-33608	sentence	denotes	Micrographs were obtained with a Jeol JSM-35CF scanning electron microscope.
T8191	33532-33543	NNS	denotes	Micrographs
T8193	33544-33548	VBD	denotes	were
T8192	33549-33557	VBN	denotes	obtained
T8194	33558-33562	IN	denotes	with
T8195	33563-33564	DT	denotes	a
T8197	33565-33569	NNP	denotes	Jeol
T8199	33570-33573	NNP	denotes	JSM
T8200	33573-33574	HYPH	denotes	-
T8198	33574-33578	NNP	denotes	35CF
T8201	33579-33587	VBG	denotes	scanning
T8202	33588-33596	NN	denotes	electron
T8196	33597-33607	NN	denotes	microscope
T8203	33607-33608	.	denotes	.
R10	T123	T116	prep	in,perturbed
R100	T228	T226	dobj	insight,provide
R1000	T1630	T1618	cc	and,make
R1001	T1732	T1731	pcomp	understanding,of
R1002	T1733	T1734	det	the,neuropathology
R1003	T1734	T1732	dobj	neuropathology,understanding
R1004	T1735	T1734	prep	of,neuropathology
R1005	T1631	T1632	amod	horizontal,cells
R1006	T1736	T1735	pobj	LCA,of
R1007	T1737	T1732	prep	in,understanding
R1008	T1738	T1739	amod	greater,detail
R1009	T1632	T1618	conj	cells,make
R101	T229	T228	prep	into,insight
R1010	T1739	T1737	pobj	detail,in
R1011	T1740	T1728	punct	", ",analyzed
R1012	T1741	T1728	nsubj	we,analyzed
R1013	T1633	T1632	cc	and,cells
R1014	T1742	T1728	aux	have,analyzed
R1015	T1743	T1744	det	the,differentiation
R1016	T1634	T1635	amod	basal,junctions
R1017	T1744	T1728	dobj	differentiation,analyzed
R1018	T1745	T1744	prep	of,differentiation
R1019	T1746	T1747	det	the,retina
R102	T230	T231	poss	Crx,function
R1020	T1635	T1632	conj	junctions,cells
R1021	T1747	T1745	pobj	retina,of
R1022	T1748	T1747	amod	outer,retina
R1023	T1749	T1744	prep	in,differentiation
R1024	T1636	T1632	prep	with,cells
R1025	T1750	T1751	nmod	Crx,mice
R1026	T1751	T1749	pobj	mice,in
R1027	T1752	T1750	punct	-,Crx
R1028	T1637	T1638	det	the,dendrites
R1029	T1753	T1750	punct	/,Crx
R103	T231	T229	pobj	function,into
R1030	T1754	T1750	punct	-,Crx
R1031	T1755	T1728	prep	at,analyzed
R1032	T1638	T1636	pobj	dendrites,with
R1033	T1756	T1757	det	the,level
R1034	T1757	T1755	pobj	level,at
R1035	T1639	T1638	prep	of,dendrites
R1036	T1758	T1757	amod	ultrastructural,level
R1037	T1759	T1728	punct	.,analyzed
R1038	T1761	T1762	det	These,retinas
R1039	T1762	T1763	nsubj	retinas,exhibit
R104	T232	T230	case	's,Crx
R1040	T1764	T1765	amod	several,defects
R1041	T1640	T1641	nmod	off,cells
R1042	T1765	T1763	dobj	defects,exhibit
R1043	T1766	T1765	amod	prominent,defects
R1044	T1767	T1763	punct	.,exhibit
R1045	T1641	T1639	pobj	cells,of
R1046	T1769	T1770	nmod	Crx,photoreceptors
R1047	T1770	T1774	nsubj	photoreceptors,demonstrate
R1048	T1642	T1640	punct	-,off
R1049	T1771	T1769	punct	-,Crx
R105	T233	T213	punct	.,created
R1050	T1772	T1769	punct	/,Crx
R1051	T1643	T1640	pobj	cone,off
R1052	T1773	T1769	punct	-,Crx
R1053	T1775	T1776	det	a,block
R1054	T1644	T1641	amod	bipolar,cells
R1055	T1776	T1774	dobj	block,demonstrate
R1056	T1777	T1776	amod	complete,block
R1057	T1778	T1776	prep	in,block
R1058	T1645	T1618	punct	.,make
R1059	T1779	T1780	amod	outer,segment
R106	T235	T236	prep	In,performed
R1060	T1647	T1648	det	The,factors
R1061	T1780	T1781	compound	segment,formation
R1062	T1648	T1649	nsubj	factors,are
R1063	T1781	T1778	pobj	formation,in
R1064	T1782	T1774	prep	at,demonstrate
R1065	T1650	T1648	acl	regulating,factors
R1066	T1783	T1784	det	the,stage
R1067	T1784	T1782	pobj	stage,at
R1068	T1785	T1784	compound	elongation,stage
R1069	T1786	T1774	punct	.,demonstrate
R107	T237	T238	det	this,study
R1070	T1651	T1652	det	the,formation
R1071	T1788	T1789	advmod	Further,exhibit
R1072	T1652	T1650	dobj	formation,regulating
R1073	T1790	T1789	punct	", ",exhibit
R1074	T1653	T1652	prep	of,formation
R1075	T1791	T1792	det	these,cells
R1076	T1792	T1789	nsubj	cells,exhibit
R1077	T1793	T1794	amod	abnormal,morphology
R1078	T1794	T1789	dobj	morphology,exhibit
R1079	T1654	T1655	det	the,synapses
R108	T238	T235	pobj	study,In
R1080	T1795	T1794	amod	synaptic,morphology
R1081	T1655	T1653	pobj	synapses,of
R1082	T1796	T1789	punct	", ",exhibit
R1083	T1797	T1798	advmod	thereby,broadening
R1084	T1798	T1789	advcl	broadening,exhibit
R1085	T1656	T1655	compound	photoreceptor,synapses
R1086	T1799	T1800	det	the,function
R1087	T1800	T1798	dobj	function,broadening
R1088	T1657	T1658	advmod	completely,unknown
R1089	T1658	T1649	acomp	unknown,are
R109	T239	T236	punct	", ",performed
R1090	T1801	T1800	prep	of,function
R1091	T1802	T1801	pobj	Crx,of
R1092	T1803	T1798	prep	to,broadening
R1093	T1804	T1805	compound	photoreceptor,synaptogenesis
R1094	T1805	T1803	pobj	synaptogenesis,to
R1095	T1659	T1649	punct	.,are
R1096	T1806	T1789	punct	.,exhibit
R1097	T1808	T1809	nsubj	This,represents
R1098	T1661	T1662	advmod	At,one
R1099	T1810	T1811	det	the,report
R11	T124	T125	det	the,retina
R110	T240	T241	det	an,analysis
R1100	T1811	T1809	dobj	report,represents
R1101	T1662	T1664	nummod	one,protein
R1102	T1812	T1811	amod	first,report
R1103	T1813	T1814	advmod	strongly,implicating
R1104	T1814	T1811	acl	implicating,report
R1105	T1663	T1662	advmod	least,one
R1106	T1664	T1667	nsubj	protein,contains
R1107	T1815	T1816	det	the,process
R1108	T1816	T1814	dobj	process,implicating
R1109	T1665	T1664	nmod	photoreceptor,protein
R111	T241	T236	nsubjpass	analysis,performed
R1110	T1817	T1816	prep	of,process
R1111	T1818	T1819	compound	synapse,formation
R1112	T1819	T1817	pobj	formation,of
R1113	T1666	T1664	amod	synaptic,protein
R1114	T1820	T1814	prep	in,implicating
R1115	T1821	T1820	pobj	LCA,in
R1116	T1822	T1809	punct	.,represents
R1117	T1668	T1664	punct	", ",protein
R1118	T1669	T1664	appos	HRG4,protein
R1119	T1670	T1667	punct	", ",contains
R112	T242	T241	amod	ultrastructural,analysis
R1120	T1671	T1672	det	a,sequence
R1121	T1672	T1667	dobj	sequence,contains
R1122	T1673	T1672	amod	potential,sequence
R1123	T1674	T1672	compound	Crx,sequence
R1124	T1675	T1672	compound	target,sequence
R1125	T1676	T1667	prep	in,contains
R1126	T1677	T1678	poss	its,sequence
R1127	T1678	T1676	pobj	sequence,in
R1128	T1679	T1678	amod	transcriptional,sequence
R1129	T1680	T1678	amod	regulatory,sequence
R113	T243	T241	prep	of,analysis
R1130	T1681	T1682	punct	[,33
R1131	T1682	T1667	parataxis	33,contains
R1132	T1683	T1682	punct	],33
R1133	T1684	T1667	punct	.,contains
R1134	T1686	T1687	amod	Few,studies
R1135	T1687	T1688	nsubj	studies,extended
R1136	T1689	T1687	prep	of,studies
R1137	T1690	T1691	compound	LCA,models
R1138	T1691	T1689	pobj	models,of
R1139	T1692	T1691	compound	animal,models
R114	T244	T245	det	the,retina
R1140	T1693	T1688	aux	have,extended
R1141	T1694	T1695	poss	their,examination
R1144	T2359	T2360	amod	Multiple,pathologies
R1145	T2361	T2360	prep	in,pathologies
R1146	T2362	T2363	det	the,layer
R1147	T2363	T2361	pobj	layer,in
R1148	T2364	T2365	amod	outer,segment
R1149	T2365	T2363	compound	segment,layer
R115	T245	T243	pobj	retina,of
R1150	T2366	T2360	prep	in,pathologies
R1151	T2367	T2368	nmod	Crx,mice
R1152	T2368	T2366	pobj	mice,in
R1153	T2369	T2367	punct	-,Crx
R1154	T2370	T2367	punct	/,Crx
R1155	T2371	T2367	punct	-,Crx
R1156	T2373	T2374	det	A,protocol
R1157	T2374	T2379	nsubjpass	protocol,used
R1158	T2375	T2374	amod	standard,protocol
R1159	T2376	T2374	amod	knock,protocol
R116	T246	T245	amod	developing,retina
R1160	T2377	T2376	punct	-,knock
R1161	T2378	T2376	prt	out,knock
R1162	T2380	T2379	auxpass	was,used
R1163	T2381	T2382	aux	to,generate
R1164	T2382	T2379	advcl	generate,used
R1165	T2383	T2382	dobj	mice,generate
R1166	T2384	T2385	prep	in,targeted
R1167	T2385	T2383	relcl	targeted,mice
R1168	T2386	T2384	pobj	which,in
R1169	T2387	T2388	det	the,homeodomain
R117	T247	T245	prep	in,retina
R1170	T2388	T2385	nsubjpass	homeodomain,targeted
R1171	T2389	T2388	prep	of,homeodomain
R1172	T2390	T2389	pobj	Crx,of
R1173	T2391	T2390	punct	-,Crx
R1174	T2392	T2390	punct	/,Crx
R1175	T2393	T2390	punct	-,Crx
R1176	T2394	T2385	auxpass	was,targeted
R1177	T2395	T2385	cc	and,targeted
R1178	T2396	T2385	conj	deleted,targeted
R1179	T2397	T2379	punct	.,used
R118	T248	T249	compound	Crx,mice
R1180	T2399	T2400	nsubjpass	Generation,reported
R1181	T2401	T2399	prep	of,Generation
R1182	T2402	T2403	det	these,mice
R1183	T2403	T2401	pobj	mice,of
R1184	T2404	T2403	nmod	Crx,mice
R1185	T2405	T2404	punct	-,Crx
R1186	T2406	T2404	punct	/,Crx
R1187	T2407	T2404	punct	-,Crx
R1188	T2408	T2400	aux	has,reported
R1189	T2409	T2400	auxpass	been,reported
R119	T249	T247	pobj	mice,in
R1190	T2410	T2400	advmod	elsewhere,reported
R1191	T2411	T2412	punct	[,34
R1192	T2412	T2400	parataxis	34,reported
R1193	T2413	T2412	punct	],34
R1194	T2414	T2400	punct	.,reported
R1195	T2416	T2417	prep	In,examined
R1196	T2418	T2419	det	this,study
R1197	T2419	T2416	pobj	study,In
R1198	T2420	T2417	punct	", ",examined
R1199	T2421	T2417	prep	in,examined
R12	T125	T123	pobj	retina,in
R120	T250	T249	compound	mutant,mice
R1200	T2422	T2421	pobj	order,in
R1201	T2423	T2424	aux	to,characterize
R1202	T2424	T2422	acl	characterize,order
R1203	T2425	T2424	advmod	further,characterize
R1204	T2426	T2427	det	the,role
R1205	T2427	T2424	dobj	role,characterize
R1206	T2428	T2427	prep	of,role
R1207	T2429	T2428	pobj	Crx,of
R1208	T2430	T2427	prep	in,role
R1209	T2431	T2432	compound	photoreceptor,morphogenesis
R121	T251	T236	auxpass	was,performed
R1210	T2432	T2430	pobj	morphogenesis,in
R1211	T2433	T2417	punct	", ",examined
R1212	T2434	T2435	det	the,retinae
R1213	T2435	T2417	nsubjpass	retinae,examined
R1214	T2436	T2435	amod	outer,retinae
R1215	T2437	T2435	prep	from,retinae
R1216	T2438	T2439	nmod	Crx,mice
R1217	T2439	T2437	pobj	mice,from
R1218	T2440	T2438	punct	-,Crx
R1219	T2441	T2438	punct	/,Crx
R122	T252	T236	punct	.,performed
R1220	T2442	T2438	punct	-,Crx
R1221	T2443	T2417	auxpass	were,examined
R1222	T2444	T2417	advcl	using,examined
R1223	T2445	T2446	compound	transmission,microscopy
R1224	T2446	T2444	dobj	microscopy,using
R1225	T2447	T2446	compound	electron,microscopy
R1226	T2448	T2417	punct	.,examined
R1227	T2450	T2451	prep	At,were
R1228	T2452	T2453	amod	postnatal,day
R1229	T2453	T2450	pobj	day,At
R123	T254	T255	amod	Outer,morphogenesis
R1230	T2454	T2453	nummod	21,day
R1231	T2455	T2453	punct	(,day
R1232	T2456	T2453	appos	P21,day
R1233	T2457	T2451	punct	),were
R1234	T2458	T2451	punct	", ",were
R1235	T2459	T2460	advmod	when,exhibited
R1236	T2460	T2451	advcl	exhibited,were
R1237	T2461	T2462	nmod	Crx,photoreceptors
R1238	T2462	T2460	nsubj	photoreceptors,exhibited
R1239	T2463	T2461	punct	+,Crx
R124	T255	T257	nsubjpass	morphogenesis,found
R1240	T2464	T2461	punct	/,Crx
R1241	T2465	T2461	punct	+,Crx
R1242	T2466	T2467	amod	robust,segments
R1243	T2467	T2460	dobj	segments,exhibited
R1244	T2468	T2467	amod	outer,segments
R1245	T2469	T2470	punct	(,os
R1246	T2470	T2460	parataxis	os,exhibited
R1247	T2471	T2472	compound	Figure,1A
R1248	T2472	T2470	dep	1A,os
R1249	T2473	T2470	punct	", ",os
R125	T256	T255	compound	segment,morphogenesis
R1250	T2474	T2470	punct	),os
R1251	T2475	T2451	punct	", ",were
R1252	T2476	T2477	nmod	Crx,retinas
R1253	T2477	T2451	nsubj	retinas,were
R1254	T2478	T2476	punct	-,Crx
R1255	T2479	T2476	punct	/,Crx
R1256	T2480	T2476	punct	-,Crx
R1257	T2481	T2451	prep	without,were
R1258	T2482	T2483	det	a,layer
R1259	T2483	T2481	pobj	layer,without
R126	T258	T257	auxpass	was,found
R1260	T2484	T2483	amod	recognizable,layer
R1261	T2485	T2486	amod	outer,segment
R1262	T2486	T2483	compound	segment,layer
R1263	T2487	T2488	punct	(,Figure
R1264	T2488	T2451	parataxis	Figure,were
R1265	T2489	T2488	nummod	1B,Figure
R1266	T2490	T2488	punct	),Figure
R1267	T2491	T2451	punct	.,were
R1268	T2493	T2494	nmod	Crx,photoreceptors
R1269	T2494	T2498	nsubj	photoreceptors,had
R127	T259	T260	aux	to,blocked
R1270	T2495	T2493	punct	-,Crx
R1271	T2496	T2493	punct	/,Crx
R1272	T2497	T2493	punct	-,Crx
R1273	T2499	T2500	amod	inner,segments
R1274	T2500	T2498	dobj	segments,had
R1275	T2501	T2498	punct	", ",had
R1276	T2502	T2498	advcl	demonstrating,had
R1277	T2503	T2504	advmod	at,least
R1278	T2504	T2505	advmod	least,limited
R1279	T2505	T2506	amod	limited,polarization
R128	T260	T257	xcomp	blocked,found
R1280	T2506	T2502	dobj	polarization,demonstrating
R1281	T2507	T2506	compound	photoreceptor,polarization
R1282	T2508	T2506	prep	in,polarization
R1283	T2509	T2510	det	the,mutant
R1284	T2510	T2508	pobj	mutant,in
R1285	T2511	T2510	compound	Crx,mutant
R1286	T2512	T2498	punct	", ",had
R1287	T2513	T2498	cc	but,had
R1288	T2514	T2515	det	the,segments
R1289	T2515	T2517	nsubj	segments,were
R129	T261	T260	auxpass	be,blocked
R1290	T2516	T2515	amod	inner,segments
R1291	T2517	T2498	conj	were,had
R1292	T2518	T2519	advmod	extremely,short
R1293	T2519	T2517	acomp	short,were
R1294	T2520	T2521	punct	(,Figure
R1295	T2521	T2517	parataxis	Figure,were
R1296	T2522	T2521	nummod	2,Figure
R1297	T2523	T2521	punct	),Figure
R1298	T2524	T2517	punct	.,were
R1299	T2526	T2527	advmod	Furthermore,showed
R13	T126	T125	amod	neural,retina
R130	T262	T260	prep	at,blocked
R1300	T2528	T2527	punct	", ",showed
R1301	T2529	T2530	det	the,majority
R1302	T2530	T2527	nsubj	majority,showed
R1303	T2531	T2530	prep	of,majority
R1304	T2532	T2533	amod	inner,segments
R1305	T2533	T2531	pobj	segments,of
R1306	T2534	T2535	det	some,differentiation
R1307	T2535	T2527	dobj	differentiation,showed
R1308	T2536	T2535	amod	morphological,differentiation
R1309	T2537	T2527	punct	", ",showed
R131	T263	T264	det	the,stage
R1310	T2538	T2527	advcl	having,showed
R1311	T2539	T2540	advmod	approximately,many
R1312	T2540	T2542	amod	many,mitochondria
R1313	T2541	T2540	advmod	as,many
R1314	T2542	T2538	dobj	mitochondria,having
R1315	T2543	T2542	prep	as,mitochondria
R1316	T2544	T2545	det	the,control
R1317	T2545	T2543	pobj	control,as
R1318	T2546	T2547	punct	(,1
R1319	T2547	T2538	parataxis	1,having
R132	T264	T262	pobj	stage,at
R1320	T2548	T2547	nmod	Figure,1
R1321	T2549	T2547	cc	and,1
R1322	T2550	T2547	conj	2,1
R1323	T2551	T2547	punct	),1
R1324	T2552	T2527	punct	.,showed
R1325	T2554	T2555	advmod	Occasionally,noted
R1326	T2556	T2555	punct	", ",noted
R1327	T2557	T2558	det	an,segment
R1328	T2558	T2555	nsubjpass	segment,noted
R1329	T2559	T2558	amod	inner,segment
R133	T265	T264	compound	elongation,stage
R1330	T2560	T2558	acl	undergoing,segment
R1331	T2561	T2560	dobj	lysis,undergoing
R1332	T2562	T2555	auxpass	was,noted
R1333	T2563	T2555	punct	", ",noted
R1334	T2564	T2555	advcl	appearing,noted
R1335	T2565	T2564	oprd	swollen,appearing
R1336	T2566	T2565	cc	or,swollen
R1337	T2567	T2565	conj	with,swollen
R1338	T2568	T2567	pobj	vacuoles,with
R1339	T2569	T2568	cc	and,vacuoles
R134	T266	T260	punct	", ",blocked
R1340	T2570	T2571	amod	swollen,mitochondria
R1341	T2571	T2568	conj	mitochondria,vacuoles
R1342	T2572	T2573	punct	(,shown
R1343	T2573	T2564	parataxis	shown,appearing
R1344	T2574	T2573	nsubj	data,shown
R1345	T2575	T2573	neg	not,shown
R1346	T2576	T2573	punct	),shown
R1347	T2577	T2555	punct	.,noted
R1348	T2590	T2591	compound	ceptor,i
R1349	T2601	T2600	parataxis	nd,a
R135	T267	T260	advcl	leading,blocked
R1350	T2607	T2608	amod	r,segments
R1351	T2611	T2610	amod	ar,e
R1352	T2615	T2614	agent	by,joined
R1353	T2616	T2617	det	a,cilium
R1354	T2617	T2615	pobj	cilium,by
R1355	T2618	T2617	amod	non-motile,cilium
R1356	T2619	T2617	amod	connecting,cilium
R1357	T2620	T2621	dep	that,exhibits
R1358	T2621	T2617	relcl	exhibits,cilium
R1359	T2622	T2623	det	a,arrangement
R136	T268	T267	prep	to,leading
R1360	T2623	T2621	dobj	arrangement,exhibits
R1361	T2624	T2623	amod	characteristic,arrangement
R1362	T2625	T2626	nummod	9,0
R1363	T2626	T2623	nummod	0,arrangement
R1364	T2627	T2626	punct	+,0
R1365	T2628	T2623	prep	of,arrangement
R1366	T2629	T2630	compound	microtubule,doublets
R1367	T2630	T2628	pobj	doublets,of
R1368	T2631	T2632	advmod	when,viewed
R1369	T2632	T2621	advcl	viewed,exhibits
R137	T269	T270	det	a,failure
R1370	T2633	T2632	prep	in,viewed
R1371	T2634	T2633	pobj	cross-section,in
R1372	T2635	T2614	punct	.,joined
R1373	T2637	T2638	prep	At,noted
R1374	T2639	T2637	pobj	P21,At
R1375	T2640	T2638	punct	", ",noted
R1376	T2641	T2638	prep	in,noted
R1377	T2642	T2643	nmod	Crx,retinas
R1378	T2643	T2641	pobj	retinas,in
R1379	T2644	T2642	punct	-,Crx
R138	T270	T268	pobj	failure,to
R1380	T2645	T2642	punct	/,Crx
R1381	T2646	T2642	punct	-,Crx
R1382	T2647	T2638	punct	", ",noted
R1383	T2648	T2649	amod	numerous,sections
R1384	T2649	T2638	nsubjpass	sections,noted
R1385	T2650	T2649	compound	cross,sections
R1386	T2651	T2649	prep	of,sections
R1387	T2652	T2653	amod	connecting,cilia
R1388	T2653	T2651	pobj	cilia,of
R1389	T2654	T2638	auxpass	were,noted
R139	T271	T270	prep	in,failure
R1390	T2655	T2656	punct	(,3A
R1391	T2656	T2638	parataxis	3A,noted
R1392	T2657	T2656	nmod	Figure,3A
R1393	T2658	T2656	cc	and,3A
R1394	T2659	T2656	conj	3B,3A
R1395	T2660	T2656	punct	),3A
R1396	T2661	T2638	punct	.,noted
R1397	T2663	T2664	advmod	Sporadically,contained
R1398	T2665	T2664	punct	", ",contained
R1399	T2666	T2667	amod	connecting,cilia
R14	T127	T125	prep	of,retina
R140	T272	T271	pobj	production,in
R1400	T2667	T2664	nsubj	cilia,contained
R1401	T2668	T2664	dobj	other,contained
R1402	T2669	T2668	prep	than,other
R1403	T2670	T2671	det	the,complement
R1404	T2671	T2669	pobj	complement,than
R1405	T2672	T2671	amod	typical,complement
R1406	T2673	T2671	prep	of,complement
R1407	T2674	T2675	compound	microtubule,doublets
R1408	T2675	T2673	pobj	doublets,of
R1409	T2676	T2664	punct	.,contained
R141	T273	T272	prep	of,production
R1410	T2678	T2679	prep	For,shows
R1411	T2680	T2678	pobj	example,For
R1412	T2681	T2679	punct	", ",shows
R1413	T2682	T2679	prep	in,shows
R1414	T2683	T2684	compound	Figure,3A
R1415	T2684	T2682	pobj	3A,in
R1416	T2685	T2679	punct	", ",shows
R1417	T2686	T2687	det	the,cilium
R1418	T2687	T2679	nsubj	cilium,shows
R1419	T2688	T2687	amod	connecting,cilium
R142	T274	T275	det	the,apparatus
R1420	T2689	T2687	acl	labelled,cilium
R1421	T2690	T2689	agent	by,labelled
R1422	T2691	T2690	pobj	arrowhead,by
R1423	T2692	T2691	nummod	1,arrowhead
R1424	T2693	T2679	punct	", ",shows
R1425	T2694	T2695	nummod	7,0
R1426	T2695	T2697	nummod	0,doublets
R1427	T2696	T2695	punct	+,0
R1428	T2697	T2679	dobj	doublets,shows
R1429	T2698	T2679	punct	.,shows
R143	T275	T273	pobj	apparatus,of
R1430	T2700	T2701	det	The,majority
R1431	T2701	T2702	nsubj	majority,exhibited
R1432	T2703	T2704	det	the,doublets
R1433	T2704	T2702	dobj	doublets,exhibited
R1434	T2705	T2704	amod	characteristic,doublets
R1435	T2706	T2707	nummod	9,0
R1436	T2707	T2704	nummod	0,doublets
R1437	T2708	T2707	punct	+,0
R1438	T2709	T2710	punct	(,2
R1439	T2710	T2702	parataxis	2,exhibited
R144	T276	T275	compound	phototransduction,apparatus
R1440	T2711	T2710	nmod	arrowhead,2
R1441	T2712	T2710	cc	and,2
R1442	T2713	T2710	conj	3,2
R1443	T2714	T2710	prep	in,2
R1444	T2715	T2716	compound	Figure,3A
R1445	T2716	T2714	pobj	3A,in
R1446	T2717	T2716	cc	and,3A
R1447	T2718	T2719	compound	Figure,3B
R1448	T2719	T2716	conj	3B,3A
R1449	T2720	T2710	punct	),2
R145	T277	T257	punct	.,found
R1450	T2721	T2702	punct	.,exhibited
R1451	T2723	T2724	det	These,observations
R1452	T2724	T2725	nsubj	observations,indicate
R1453	T2726	T2727	mark	that,is
R1454	T2727	T2725	ccomp	is,indicate
R1455	T2728	T2727	prep	in,is
R1456	T2729	T2728	pobj	addition,in
R1457	T2730	T2729	prep	to,addition
R1458	T2731	T2732	amod	inner,segment
R1459	T2732	T2733	compound	segment,formation
R146	T279	T280	advmod	Further,demonstrated
R1460	T2733	T2730	pobj	formation,to
R1461	T2734	T2727	punct	", ",is
R1462	T2735	T2727	nsubj	ciliogenesis,is
R1463	T2736	T2727	advmod	also,is
R1464	T2737	T2738	advmod	largely,intact
R1465	T2738	T2727	acomp	intact,is
R1466	T2739	T2727	prep	in,is
R1467	T2740	T2741	nmod	Crx,photoreceptors
R1468	T2741	T2739	pobj	photoreceptors,in
R1469	T2742	T2740	punct	-,Crx
R147	T281	T280	punct	", ",demonstrated
R1470	T2743	T2740	punct	/,Crx
R1471	T2744	T2740	punct	-,Crx
R1472	T2745	T2725	punct	.,indicate
R1473	T2747	T2748	advmod	Further,appeared
R1474	T2749	T2748	punct	", ",appeared
R1475	T2750	T2748	prep	in,appeared
R1476	T2751	T2752	nmod	Crx,retinas
R1477	T2752	T2750	pobj	retinas,in
R1478	T2753	T2751	punct	-,Crx
R1479	T2754	T2751	punct	/,Crx
R148	T282	T283	nmod	Crx,photoreceptors
R1480	T2755	T2751	punct	-,Crx
R1481	T2756	T2757	det	the,epithelium
R1482	T2757	T2748	nsubj	epithelium,appeared
R1483	T2758	T2757	nmod	retinal,epithelium
R1484	T2759	T2757	amod	pigmented,epithelium
R1485	T2760	T2757	punct	(,epithelium
R1486	T2761	T2757	appos	PE,epithelium
R1487	T2762	T2748	punct	),appeared
R1488	T2763	T2748	oprd	normal,appeared
R1489	T2764	T2748	punct	", ",appeared
R149	T283	T280	nsubj	photoreceptors,demonstrated
R1490	T2765	T2766	advmod	at,least
R1491	T2766	T2767	advmod	least,up
R1492	T2767	T2748	prep	up,appeared
R1493	T2768	T2767	prep	to,up
R1494	T2769	T2768	pobj	P21,to
R1495	T2770	T2771	punct	(,shown
R1496	T2771	T2769	parataxis	shown,P21
R1497	T2772	T2771	nsubj	data,shown
R1498	T2773	T2771	neg	not,shown
R1499	T2774	T2771	punct	),shown
R15	T128	T129	compound	Crx,mice
R150	T284	T282	punct	-,Crx
R1500	T2775	T2769	punct	", ",P21
R1501	T2776	T2777	det	the,age
R1502	T2777	T2769	appos	age,P21
R1503	T2778	T2777	amod	oldest,age
R1504	T2779	T2777	acl	examined,age
R1505	T2780	T2748	punct	.,appeared
R1506	T2787	T2786	oprd	ti,i
R1507	T2788	T2789	amod	o,n
R1508	T2792	T2791	pobj	t,o
R1509	T2796	T2795	parataxis	o,c
R151	T285	T282	punct	/,Crx
R1510	T2801	T2802	compound	e,t
R1511	T2804	T2805	compound	e,a
R1512	T2807	T2808	amod	bs,e
R1513	T2814	T2812	advcl	o,o
R1514	T2817	T2818	amod	uter,segments
R1515	T2819	T2816	punct	", ",exhibited
R1516	T2820	T2821	nmod	Crx,retinas
R1517	T2821	T2816	nsubj	retinas,exhibited
R1518	T2822	T2820	punct	-,Crx
R1519	T2823	T2820	punct	/,Crx
R152	T286	T282	punct	-,Crx
R1520	T2824	T2820	punct	-,Crx
R1521	T2825	T2826	nummod	three,pathologies
R1522	T2826	T2816	dobj	pathologies,exhibited
R1523	T2827	T2826	amod	other,pathologies
R1524	T2828	T2826	amod	notable,pathologies
R1525	T2829	T2816	prep	in,exhibited
R1526	T2830	T2831	det	the,layer
R1527	T2831	T2829	pobj	layer,in
R1528	T2832	T2833	amod	outer,segment
R1529	T2833	T2831	compound	segment,layer
R153	T287	T288	advmod	severely,abnormal
R1530	T2834	T2816	punct	.,exhibited
R1531	T2836	T2837	advmod	First,noted
R1532	T2838	T2837	punct	", ",noted
R1533	T2839	T2840	det	an,deposition
R1534	T2840	T2837	nsubjpass	deposition,noted
R1535	T2841	T2840	amod	abnormal,deposition
R1536	T2842	T2840	prep	of,deposition
R1537	T2843	T2842	pobj	matrix,of
R1538	T2844	T2843	prep	of,matrix
R1539	T2845	T2846	amod	unknown,identity
R154	T288	T289	amod	abnormal,endings
R1540	T2846	T2844	pobj	identity,of
R1541	T2847	T2837	auxpass	was,noted
R1542	T2848	T2849	punct	(,mx
R1543	T2849	T2837	parataxis	mx,noted
R1544	T2850	T2851	compound	Figure,3A
R1545	T2851	T2849	dep	3A,mx
R1546	T2852	T2849	punct	", ",mx
R1547	T2853	T2849	punct	),mx
R1548	T2854	T2837	punct	.,noted
R1549	T2856	T2857	advmod	Second,found
R155	T289	T280	dobj	endings,demonstrated
R1550	T2858	T2857	punct	", ",found
R1551	T2859	T2860	advmod	sporadically,displaced
R1552	T2860	T2861	amod	displaced,nuclei
R1553	T2861	T2857	nsubjpass	nuclei,found
R1554	T2862	T2857	auxpass	were,found
R1555	T2863	T2857	advcl	residing,found
R1556	T2864	T2863	prep	in,residing
R1557	T2865	T2866	det	the,space
R1558	T2866	T2864	pobj	space,in
R1559	T2867	T2866	acl	abutting,space
R156	T290	T289	amod	synaptic,endings
R1560	T2868	T2869	det	the,PE
R1561	T2869	T2867	dobj	PE,abutting
R1562	T2870	T2857	punct	.,found
R1563	T2872	T2873	advmod	Occasionally,appeared
R1564	T2874	T2873	punct	", ",appeared
R1565	T2875	T2876	det	these,nuclei
R1566	T2876	T2873	nsubj	nuclei,appeared
R1567	T2877	T2873	oprd	pyknotic,appeared
R1568	T2878	T2879	punct	(,n
R1569	T2879	T2873	parataxis	n,appeared
R157	T291	T289	prep	in,endings
R1570	T2880	T2881	compound	Figure,3A
R1571	T2881	T2879	dep	3A,n
R1572	T2882	T2879	punct	", ",n
R1573	T2883	T2879	punct	),n
R1574	T2884	T2873	punct	;,appeared
R1575	T2885	T2873	cc	but,appeared
R1576	T2886	T2873	punct	", ",appeared
R1577	T2887	T2888	advmod	more,frequently
R1578	T2888	T2889	advmod	frequently,exhibited
R1579	T2889	T2873	conj	exhibited,appeared
R158	T292	T293	det	the,layer
R1580	T2890	T2891	det	the,pattern
R1581	T2891	T2889	dobj	pattern,exhibited
R1582	T2892	T2891	compound	heterochromatin,pattern
R1583	T2893	T2891	amod	typical,pattern
R1584	T2894	T2893	prep	of,typical
R1585	T2895	T2894	pobj	photoreceptors,of
R1586	T2896	T2897	punct	(,shown
R1587	T2897	T2889	parataxis	shown,exhibited
R1588	T2898	T2897	nsubj	data,shown
R1589	T2899	T2897	neg	not,shown
R159	T293	T291	pobj	layer,in
R1590	T2900	T2897	punct	),shown
R1591	T2901	T2889	punct	", ",exhibited
R1592	T2902	T2903	advmod	strongly,suggesting
R1593	T2903	T2889	advcl	suggesting,exhibited
R1594	T2904	T2905	mark	that,belonged
R1595	T2905	T2903	ccomp	belonged,suggesting
R1596	T2906	T2905	nsubj	they,belonged
R1597	T2907	T2905	prep	to,belonged
R1598	T2908	T2909	amod	ectopic,photoreceptors
R1599	T2909	T2907	pobj	photoreceptors,to
R16	T129	T127	pobj	mice,of
R160	T294	T293	amod	outer,layer
R1600	T2910	T2873	punct	.,appeared
R1601	T2912	T2913	det	The,entity
R1602	T2913	T2916	nsubj	entity,were
R1603	T2914	T2913	amod	third,entity
R1604	T2915	T2913	amod	pathological,entity
R1605	T2917	T2913	acl	noted,entity
R1606	T2918	T2917	prep	in,noted
R1607	T2919	T2920	det	the,layer
R1608	T2920	T2918	pobj	layer,in
R1609	T2921	T2922	amod	outer,segment
R161	T295	T293	compound	plexiform,layer
R1610	T2922	T2920	compound	segment,layer
R1611	T2923	T2924	amod	numerous,vesicles
R1612	T2924	T2916	attr	vesicles,were
R1613	T2925	T2924	amod	small,vesicles
R1614	T2926	T2927	punct	(,arrow
R1615	T2927	T2924	parataxis	arrow,vesicles
R1616	T2928	T2929	compound	Figure,3A
R1617	T2929	T2927	compound	3A,arrow
R1618	T2930	T2927	punct	),arrow
R1619	T2931	T2932	quantmod	100,200
R162	T296	T280	punct	.,demonstrated
R1620	T2932	T2934	nummod	200,nm
R1621	T2933	T2932	quantmod	to,200
R1622	T2934	T2924	appos	nm,vesicles
R1623	T2935	T2934	prep	in,nm
R1624	T2936	T2935	pobj	diameter,in
R1625	T2937	T2916	punct	.,were
R1626	T2939	T2940	nsubj	They,appeared
R1627	T2941	T2942	aux	to,emerging
R1628	T2942	T2940	xcomp	emerging,appeared
R1629	T2943	T2942	aux	be,emerging
R163	T300	T301	nsubj	This,is
R1630	T2944	T2942	prep	from,emerging
R1631	T2945	T2946	det	the,segments
R1632	T2946	T2944	pobj	segments,from
R1633	T2947	T2946	amod	inner,segments
R1634	T2948	T2940	punct	", ",appeared
R1635	T2949	T2950	mark	as,showed
R1636	T2950	T2940	advcl	showed,appeared
R1637	T2951	T2952	amod	scanning,electron
R1638	T2952	T2953	npadvmod	electron,microscopic
R1639	T2953	T2954	amod	microscopic,images
R164	T302	T303	det	the,report
R1640	T2954	T2950	nsubj	images,showed
R1641	T2955	T2956	amod	spherical,structures
R1642	T2956	T2950	dobj	structures,showed
R1643	T2957	T2956	acl	budding,structures
R1644	T2958	T2957	prep	from,budding
R1645	T2959	T2960	det	the,segments
R1646	T2960	T2958	pobj	segments,from
R1647	T2961	T2960	amod	inner,segments
R1648	T2962	T2963	punct	(,arrow
R1649	T2963	T2950	parataxis	arrow,showed
R165	T303	T301	attr	report,is
R1650	T2964	T2965	compound	Figure,3C
R1651	T2965	T2963	dep	3C,arrow
R1652	T2966	T2963	punct	", ",arrow
R1653	T2967	T2963	punct	),arrow
R1654	T2968	T2940	punct	.,appeared
R1655	T2970	T2971	prep	In,viewed
R1656	T2972	T2970	pobj	order,In
R1657	T2973	T2974	aux	to,characterize
R1658	T2974	T2972	acl	characterize,order
R1659	T2975	T2974	advmod	further,characterize
R166	T304	T303	amod	first,report
R1660	T2976	T2977	det	the,morphogenesis
R1661	T2977	T2974	dobj	morphogenesis,characterize
R1662	T2978	T2977	prep	of,morphogenesis
R1663	T2979	T2980	nmod	Crx,photoreceptors
R1664	T2980	T2978	pobj	photoreceptors,of
R1665	T2981	T2979	punct	-,Crx
R1666	T2982	T2979	punct	/,Crx
R1667	T2983	T2979	punct	-,Crx
R1668	T2984	T2971	punct	", ",viewed
R1669	T2985	T2986	det	the,layer
R167	T305	T303	prep	of,report
R1670	T2986	T2971	nsubjpass	layer,viewed
R1671	T2987	T2986	amod	developing,layer
R1672	T2988	T2989	amod	outer,segment
R1673	T2989	T2986	compound	segment,layer
R1674	T2990	T2971	auxpass	was,viewed
R1675	T2991	T2971	prep	by,viewed
R1676	T2992	T2993	amod	scanning,microscopy
R1677	T2993	T2991	pobj	microscopy,by
R1678	T2994	T2993	compound	electron,microscopy
R1679	T2995	T2971	prep	at,viewed
R168	T306	T307	det	a,defect
R1680	T2996	T2995	pobj	P7,at
R1681	T2997	T2996	punct	", ",P7
R1682	T2998	T2996	conj	P14,P7
R1683	T2999	T2998	cc	and,P14
R1684	T3000	T2998	conj	P21,P14
R1685	T3001	T3002	punct	(,Figure
R1686	T3002	T2971	parataxis	Figure,viewed
R1687	T3003	T3002	nummod	4,Figure
R1688	T3004	T3002	punct	),Figure
R1689	T3005	T2971	punct	.,viewed
R169	T307	T305	pobj	defect,of
R1690	T3007	T3008	prep	In,noted
R1691	T3009	T3010	nmod	Crx,retinas
R1692	T3010	T3007	pobj	retinas,In
R1693	T3011	T3009	punct	+,Crx
R1694	T3012	T3009	punct	/,Crx
R1695	T3013	T3009	punct	+,Crx
R1696	T3014	T3008	punct	", ",noted
R1697	T3015	T3016	nmod	photoreceptor,segments
R1698	T3016	T3008	nsubjpass	segments,noted
R1699	T3017	T3016	amod	inner,segments
R17	T130	T129	compound	mutant,mice
R170	T308	T307	compound	synaptogenesis,defect
R1700	T3018	T3016	punct	", ",segments
R1701	T3019	T3020	amod	connecting,cilia
R1702	T3020	T3016	conj	cilia,segments
R1703	T3021	T3020	punct	", ",cilia
R1704	T3022	T3020	cc	and,cilia
R1705	T3023	T3024	det	the,structures
R1706	T3024	T3020	conj	structures,cilia
R1707	T3025	T3024	amod	first,structures
R1708	T3026	T3024	amod	rudimentary,structures
R1709	T3027	T3028	amod	outer,segment
R171	T309	T307	prep	in,defect
R1710	T3028	T3024	compound	segment,structures
R1711	T3029	T3008	auxpass	were,noted
R1712	T3030	T3008	prep	at,noted
R1713	T3031	T3030	pobj	P7,at
R1714	T3032	T3008	punct	.,noted
R1715	T3034	T3035	prep	In,emerging
R1716	T3036	T3037	det	the,retina
R1717	T3037	T3034	pobj	retina,In
R1718	T3038	T3037	nmod	Crx,retina
R1719	T3039	T3038	punct	-,Crx
R172	T310	T311	det	an,model
R1720	T3040	T3038	punct	/,Crx
R1721	T3041	T3038	punct	-,Crx
R1722	T3042	T3035	punct	", ",emerging
R1723	T3043	T3044	advmod	only,cilium
R1724	T3044	T3035	nsubjpass	cilium,emerging
R1725	T3045	T3044	det	an,cilium
R1726	T3046	T3044	amod	occassional,cilium
R1727	T3047	T3044	amod	connecting,cilium
R1728	T3048	T3035	auxpass	was,emerging
R1729	T3049	T3035	aux	noted,emerging
R173	T311	T309	pobj	model,in
R1730	T3050	T3035	prep	from,emerging
R1731	T3051	T3052	amod	inner,segments
R1732	T3052	T3050	pobj	segments,from
R1733	T3053	T3035	prep	at,emerging
R1734	T3054	T3055	det	this,stage
R1735	T3055	T3053	pobj	stage,at
R1736	T3056	T3057	punct	(,4A
R1737	T3057	T3035	parataxis	4A,emerging
R1738	T3058	T3057	compound	Figure,4A
R1739	T3059	T3057	cc	and,4A
R174	T312	T311	compound	animal,model
R1740	T3060	T3057	conj	4B,4A
R1741	T3061	T3057	punct	),4A
R1742	T3062	T3035	punct	.,emerging
R1743	T3064	T3065	det	This,observation
R1744	T3065	T3066	nsubjpass	observation,confirmed
R1745	T3067	T3066	auxpass	was,confirmed
R1746	T3068	T3066	prep	by,confirmed
R1747	T3069	T3068	pobj	comparison,by
R1748	T3070	T3069	prep	with,comparison
R1749	T3071	T3072	compound	transmission,micrographs
R175	T313	T311	prep	for,model
R1750	T3072	T3070	pobj	micrographs,with
R1751	T3073	T3072	compound	electron,micrographs
R1752	T3074	T3075	punct	(,Figure
R1753	T3075	T3066	parataxis	Figure,confirmed
R1754	T3076	T3075	nummod	5,Figure
R1755	T3077	T3075	punct	),Figure
R1756	T3078	T3066	punct	.,confirmed
R1757	T3080	T3081	det	These,differences
R1758	T3081	T3082	nsubj	differences,are
R1759	T3083	T3084	det	the,differences
R176	T314	T313	pobj	LCA,for
R1760	T3084	T3082	attr	differences,are
R1761	T3085	T3084	amod	earliest,differences
R1762	T3086	T3084	amod	noted,differences
R1763	T3087	T3084	prep	between,differences
R1764	T3088	T3089	nmod	Crx,photoreceptors
R1765	T3089	T3087	pobj	photoreceptors,between
R1766	T3090	T3088	punct	+,Crx
R1767	T3091	T3088	punct	/,Crx
R1768	T3092	T3088	punct	+,Crx
R1769	T3093	T3088	cc	and,Crx
R177	T315	T301	punct	.,is
R1770	T3094	T3088	conj	Crx,Crx
R1771	T3095	T3094	punct	-,Crx
R1772	T3096	T3094	punct	/,Crx
R1773	T3097	T3094	punct	-,Crx
R1774	T3098	T3082	punct	.,are
R1775	T3100	T3101	prep	At,noted
R1776	T3102	T3100	pobj	P14,At
R1777	T3103	T3101	punct	", ",noted
R1778	T3104	T3105	amod	elongating,segments
R1779	T3105	T3101	nsubjpass	segments,noted
R178	T317	T318	det	These,data
R1780	T3106	T3105	amod	outer,segments
R1781	T3107	T3101	auxpass	were,noted
R1782	T3108	T3101	prep	on,noted
R1783	T3109	T3110	nmod	Crx,photoreceptors
R1784	T3110	T3108	pobj	photoreceptors,on
R1785	T3111	T3109	punct	+,Crx
R1786	T3112	T3109	punct	/,Crx
R1787	T3113	T3109	punct	+,Crx
R1788	T3114	T3101	punct	", ",noted
R1789	T3115	T3116	advmod	occasionally,demonstrating
R179	T318	T319	nsubj	data,confirm
R1790	T3116	T3101	advcl	demonstrating,noted
R1791	T3117	T3118	det	a,structure
R1792	T3118	T3116	dobj	structure,demonstrating
R1793	T3119	T3120	npadvmod	paddle,like
R1794	T3120	T3118	amod	like,structure
R1795	T3121	T3120	punct	-,like
R1796	T3122	T3116	prep	at,demonstrating
R1797	T3123	T3124	poss	their,apex
R1798	T3124	T3122	pobj	apex,at
R1799	T3125	T3126	punct	(,os
R18	T135	T136	prep	In,are
R180	T320	T321	det	the,role
R1800	T3126	T3116	parataxis	os,demonstrating
R1801	T3127	T3128	compound	Figure,4C
R1802	T3128	T3126	dep	4C,os
R1803	T3129	T3126	punct	", ",os
R1804	T3130	T3126	punct	),os
R1805	T3131	T3101	punct	.,noted
R1806	T3133	T3134	prep	In,demonstrated
R1807	T3135	T3136	nmod	Crx,retinae
R1808	T3136	T3133	pobj	retinae,In
R1809	T3137	T3135	punct	-,Crx
R181	T321	T319	dobj	role,confirm
R1810	T3138	T3135	punct	/,Crx
R1811	T3139	T3135	punct	-,Crx
R1812	T3140	T3134	punct	", ",demonstrated
R1813	T3141	T3142	det	the,majority
R1814	T3142	T3134	nsubj	majority,demonstrated
R1815	T3143	T3142	amod	vast,majority
R1816	T3144	T3142	prep	of,majority
R1817	T3145	T3144	pobj	photoreceptors,of
R1818	T3153	T3151	pobj	segments,without
R1819	T3146	T3145	prep	at,photoreceptors
R182	T322	T321	amod	essential,role
R1820	T3154	T3155	punct	(,cc
R1821	T3147	T3148	det	this,stage
R1822	T3155	T3134	parataxis	cc,demonstrated
R1823	T3156	T3157	compound	Figure,4D
R1824	T3148	T3146	pobj	stage,at
R1825	T3157	T3155	dep	4D,cc
R1826	T3158	T3155	punct	", ",cc
R1827	T3149	T3150	amod	connecting,cilia
R1828	T3159	T3155	punct	),cc
R1829	T3160	T3134	punct	.,demonstrated
R183	T323	T324	det	this,gene
R1830	T3150	T3134	dobj	cilia,demonstrated
R1831	T3162	T3163	advmod	Sporadically,exhibit
R1832	T3151	T3150	prep	without,cilia
R1833	T3164	T3163	punct	", ",exhibit
R1834	T3165	T3166	nmod	Crx,photoreceptors
R1835	T3166	T3163	nsubj	photoreceptors,exhibit
R1836	T3152	T3153	amod	outer,segments
R1837	T3167	T3165	punct	-,Crx
R1838	T3168	T3165	punct	/,Crx
R1839	T3258	T3259	compound	Figure,4F
R184	T324	T325	nsubj	gene,plays
R1840	T3169	T3165	punct	-,Crx
R1841	T3170	T3163	aux	would,exhibit
R1842	T3171	T3172	det	an,structure
R1843	T3259	T3257	dep	4F,cc
R1844	T3172	T3163	dobj	structure,exhibit
R1845	T3173	T3172	amod	irregular,structure
R1846	T3174	T3172	acl	extending,structure
R1847	T3260	T3257	punct	", ",cc
R1848	T3175	T3174	prep	from,extending
R1849	T3176	T3177	det	a,cilium
R185	T325	T321	advcl	plays,role
R1850	T3177	T3175	pobj	cilium,from
R1851	T3261	T3257	punct	),cc
R1852	T3178	T3177	amod	connecting,cilium
R1853	T3179	T3180	punct	(,cc*
R1854	T3262	T3242	punct	.,noted
R1855	T3180	T3174	parataxis	cc*,extending
R1856	T3181	T3182	compound	Figure,4D
R1857	T3182	T3180	dep	4D,cc*
R1858	T3183	T3180	punct	", ",cc*
R1859	T3264	T3265	amod	Serial,examination
R186	T326	T325	prep	in,plays
R1860	T3184	T3180	punct	),cc*
R1861	T3185	T3186	advmod	perhaps,representing
R1862	T3186	T3172	acl	representing,structure
R1863	T3265	T3266	nsubj	examination,demonstrated
R1864	T3187	T3188	det	a,segment
R1865	T3188	T3186	dobj	segment,representing
R1866	T3189	T3188	amod	malformed,segment
R1867	T3190	T3188	amod	outer,segment
R1868	T3191	T3163	punct	.,exhibit
R1869	T3267	T3265	prep	of,examination
R187	T327	T328	amod	multiple,aspects
R1870	T3193	T3194	amod	Such,structures
R1871	T3194	T3195	nsubjpass	structures,observed
R1872	T3196	T3195	auxpass	were,observed
R1873	T3197	T3195	dobj	also,observed
R1874	T3268	T3269	nmod	Crx,photoreceptors
R1875	T3198	T3195	prep	at,observed
R1876	T3199	T3198	pobj	P21,at
R1877	T3269	T3267	pobj	photoreceptors,of
R1878	T3200	T3201	punct	(,cc*
R1879	T3201	T3195	parataxis	cc*,observed
R188	T328	T326	pobj	aspects,in
R1880	T3202	T3203	compound	Figure,4F
R1881	T3270	T3268	punct	-,Crx
R1882	T3203	T3201	dep	4F,cc*
R1883	T3204	T3201	punct	", ",cc*
R1884	T3205	T3201	punct	),cc*
R1885	T3271	T3268	punct	/,Crx
R1886	T3206	T3195	punct	.,observed
R1887	T3272	T3268	punct	-,Crx
R1888	T3208	T3209	det	These,segments
R1889	T3209	T3214	nsubjpass	segments,noted
R189	T329	T328	prep	of,aspects
R1890	T3210	T3209	amod	putative,segments
R1891	T3273	T3265	prep	at,examination
R1892	T3211	T3209	punct	", ",segments
R1893	T3212	T3209	amod	abnormal,segments
R1894	T3213	T3209	amod	outer,segments
R1895	T3274	T3273	pobj	P7,at
R1896	T3215	T3214	auxpass	were,noted
R1897	T3216	T3217	advmod	only,rarely
R1898	T3275	T3274	punct	", ",P7
R1899	T3217	T3214	advmod	rarely,noted
R19	T137	T138	poss	Leber,amaurosis
R190	T330	T331	compound	photoreceptor,development
R1900	T3276	T3274	conj	P10,P7
R1901	T3277	T3276	punct	", ",P10
R1902	T3218	T3214	prep	in,noted
R1903	T3219	T3218	pobj	Crx,in
R1904	T3278	T3276	conj	P14,P10
R1905	T3220	T3219	punct	+,Crx
R1906	T3221	T3219	punct	/,Crx
R1907	T3222	T3219	punct	+,Crx
R1908	T3279	T3278	punct	", ",P14
R1909	T3280	T3278	cc	and,P14
R191	T331	T329	pobj	development,of
R1910	T3223	T3214	prep	at,noted
R1911	T3224	T3223	pobj	P14,at
R1912	T3281	T3278	conj	P21,P14
R1913	T3225	T3214	punct	", ",noted
R1914	T3226	T3214	cc	and,noted
R1915	T3282	T3265	prep	by,examination
R1916	T3227	T3214	conj	never,noted
R1917	T3228	T3227	prep	at,never
R1918	T3229	T3228	pobj	P21,at
R1919	T3230	T3231	punct	(,cc
R192	T332	T319	cc	and,confirm
R1920	T3231	T3227	parataxis	cc,never
R1921	T3283	T3282	pobj	TEM,by
R1922	T3232	T3233	compound	Figure,4C
R1923	T3233	T3231	dep	4C,cc
R1924	T3234	T3233	cc	and,4C
R1925	T3284	T3266	punct	", ",demonstrated
R1926	T3235	T3233	conj	4E,4C
R1927	T3236	T3231	punct	", ",cc
R1928	T3237	T3231	punct	*,cc
R1929	T3285	T3286	det	a,lack
R193	T333	T319	conj	extend,confirm
R1930	T3238	T3231	punct	),cc
R1931	T3239	T3214	punct	.,noted
R1932	T3286	T3266	dobj	lack,demonstrated
R1933	T3241	T3242	advmod	Further,noted
R1934	T3243	T3242	punct	", ",noted
R1935	T3287	T3286	amod	distinctive,lack
R1936	T3244	T3242	prep	in,noted
R1937	T3245	T3246	nmod	Crx,photoreceptors
R1938	T3246	T3244	pobj	photoreceptors,in
R1939	T3288	T3286	prep	of,lack
R194	T334	T335	poss	our,understanding
R1940	T3247	T3245	punct	-,Crx
R1941	T3248	T3245	punct	/,Crx
R1942	T3249	T3245	punct	-,Crx
R1943	T3289	T3290	det	any,structure
R1944	T3250	T3242	punct	", ",noted
R1945	T3251	T3252	advmod	unusually,long
R1946	T3290	T3288	pobj	structure,of
R1947	T3252	T3253	amod	long,cilia
R1948	T3253	T3242	nsubjpass	cilia,noted
R1949	T3254	T3253	amod	connecting,cilia
R195	T335	T333	dobj	understanding,extend
R1950	T3291	T3290	amod	interpretable,structure
R1951	T3255	T3242	auxpass	were,noted
R1952	T3256	T3257	punct	(,cc
R1953	T3257	T3242	parataxis	cc,noted
R1954	T3292	T3291	prep	as,interpretable
R1955	T3293	T3294	amod	orderly,stacks
R1956	T3294	T3292	pobj	stacks,as
R1957	T3295	T3294	prep	of,stacks
R1958	T3296	T3295	pobj	discs,of
R1959	T3297	T3296	cc	or,discs
R196	T336	T335	prep	of,understanding
R1960	T3298	T3299	amod	forming,discs
R1961	T3299	T3296	conj	discs,discs
R1962	T3300	T3266	punct	.,demonstrated
R1963	T3302	T3303	det	These,data
R1964	T3356	T3355	prep	o,ph
R1965	T3303	T3304	nsubj	data,demonstrate
R1966	T3305	T3306	det	a,absence
R1967	T3306	T3304	dobj	absence,demonstrate
R1968	T3307	T3306	amod	complete,absence
R1969	T3308	T3306	prep	of,absence
R197	T337	T338	det	the,pathology
R1970	T3309	T3310	amod	normal,formation
R1971	T3310	T3308	pobj	formation,of
R1972	T3367	T3368	det	the,photoreceptors
R1973	T3311	T3312	amod	outer,segment
R1974	T3368	T3366	pobj	photoreceptors,f
R1975	T3369	T3368	amod	malformed,photoreceptors
R1976	T3312	T3310	compound	segment,formation
R1977	T3370	T3368	nmod	Crx,photoreceptors
R1978	T3371	T3370	punct	-,Crx
R1979	T3313	T3306	prep	in,absence
R198	T338	T336	pobj	pathology,of
R1980	T3372	T3370	punct	/,Crx
R1981	T3373	T3370	punct	-,Crx
R1982	T3374	T3365	auxpass	was,compared
R1983	T3314	T3315	det	the,mouse
R1984	T3375	T3365	prep	to,compared
R1985	T3376	T3377	nmod	rhodopsin,photoreceptors
R1986	T3315	T3313	pobj	mouse,in
R1987	T3316	T3315	compound	Crx,mouse
R1988	T3377	T3375	pobj	photoreceptors,to
R1989	T3317	T3315	compound	mutant,mouse
R199	T339	T338	amod	basic,pathology
R1990	T3378	T3376	punct	-,rhodopsin
R1991	T3379	T3376	punct	/,rhodopsin
R1992	T3380	T3376	punct	-,rhodopsin
R1993	T3318	T3306	punct	", ",absence
R1994	T3381	T3376	cc	and,rhodopsin
R1995	T3382	T3376	conj	peripherin,rhodopsin
R1996	T3383	T3382	punct	-,peripherin
R1997	T3319	T3306	cc	and,absence
R1998	T3384	T3382	punct	/,peripherin
R1999	T3385	T3382	punct	-,peripherin
R20	T138	T135	pobj	amaurosis,In
R200	T340	T338	prep	of,pathology
R2000	T3386	T3365	punct	.,compared
R2001	T3320	T3321	det	the,arrest
R2002	T3321	T3306	conj	arrest,absence
R2003	T3322	T3321	prep	of,arrest
R2004	T3323	T3322	pobj	development,of
R2005	T3388	T3389	nsubj	Rhodopsin,are
R2006	T3390	T3388	cc	and,Rhodopsin
R2007	T3324	T3323	prep	of,development
R2008	T3391	T3388	conj	peripherin,Rhodopsin
R2009	T3392	T3393	nummod	two,genes
R201	T341	T340	pobj	LCA,of
R2010	T3325	T3326	det	the,appendage
R2011	T3393	T3389	attr	genes,are
R2012	T3394	T3395	npadvmod	photoreceptor,specific
R2013	T3395	T3393	amod	specific,genes
R2014	T3326	T3324	pobj	appendage,of
R2015	T3396	T3395	punct	-,specific
R2016	T3397	T3398	poss	whose,expression
R2017	T3398	T3399	dep	expression,downregulated
R2018	T3327	T3326	compound	photoreceptor,appendage
R2019	T3399	T3393	relcl	downregulated,genes
R202	T342	T319	punct	.,confirm
R2020	T3400	T3399	auxpass	is,downregulated
R2021	T3401	T3399	advmod	significantly,downregulated
R2022	T3328	T3321	prep	at,arrest
R2023	T3402	T3399	prep	in,downregulated
R2024	T3403	T3404	det	the,retinae
R2025	T3404	T3402	pobj	retinae,in
R2026	T3405	T3404	nmod	Crx,retinae
R2027	T3406	T3405	punct	-,Crx
R2028	T3329	T3330	det	the,stage
R2029	T3407	T3405	punct	/,Crx
R203	T115	T116	nsubjpass	Synaptogenesis,perturbed
R2030	T3408	T3405	punct	-,Crx
R2031	T3409	T3410	punct	[,35
R2032	T3410	T3399	parataxis	35,downregulated
R2033	T3330	T3328	pobj	stage,at
R2034	T3411	T3410	nummod	10,35
R2035	T3412	T3410	punct	",",35
R2036	T3331	T3330	compound	elongation,stage
R2037	T3413	T3410	nummod	34,35
R2038	T3414	T3410	punct	",",35
R2039	T3415	T3410	punct	],35
R2040	T3332	T3330	prep	of,stage
R2041	T3416	T3389	punct	.,are
R2042	T3333	T3334	amod	outer,segment
R2043	T3418	T3419	nmod	Loss,mutations
R2044	T3419	T3422	nsubjpass	mutations,reported
R2045	T3420	T3418	prep	of,Loss
R2046	T3334	T3335	compound	segment,formation
R2047	T3421	T3420	pobj	function,of
R2048	T3423	T3419	prep	in,mutations
R2049	T3335	T3332	pobj	formation,of
R2050	T3424	T3423	pobj	each,in
R2051	T3425	T3424	prep	of,each
R2052	T3426	T3427	det	these,genes
R2053	T3336	T3304	punct	.,demonstrate
R2054	T3427	T3425	pobj	genes,of
R2055	T3428	T3422	advmod	separately,reported
R2056	T3429	T3422	aux	have,reported
R2057	T3430	T3422	auxpass	been,reported
R2058	T3431	T3432	aux	to,result
R2059	T3432	T3422	xcomp	result,reported
R2060	T3433	T3432	prep	in,result
R2061	T3434	T3435	det	a,failure
R2062	T3435	T3433	pobj	failure,in
R2063	T3436	T3437	aux	to,elaborate
R2064	T3437	T3435	acl	elaborate,failure
R2065	T3438	T3439	amod	outer,segments
R2066	T3439	T3437	dobj	segments,elaborate
R2067	T3440	T3441	punct	[,30
R2068	T3441	T3422	parataxis	30,reported
R2069	T3442	T3441	nummod	29,30
R2070	T3443	T3441	punct	",",30
R2071	T3444	T3441	punct	],30
R2072	T3445	T3422	punct	.,reported
R2073	T3447	T3448	nsubj	Photoreceptors,appeared
R2074	T3449	T3447	prep	from,Photoreceptors
R2075	T3450	T3451	det	these,mice
R2076	T3451	T3449	pobj	mice,from
R2077	T3452	T3451	nummod	two,mice
R2078	T3453	T3451	amod	mutant,mice
R2079	T3454	T3451	acl	examined,mice
R2080	T3455	T3454	prep	by,examined
R2081	T3456	T3455	pobj	SEM,by
R2082	T3457	T3454	prep	from,examined
R2083	T3458	T3459	det	the,side
R2084	T3459	T3457	pobj	side,from
R2085	T3460	T3459	amod	scleral,side
R2086	T3461	T3462	advmod	highly,similar
R2087	T3462	T3448	oprd	similar,appeared
R2088	T3463	T3462	prep	to,similar
R2089	T3464	T3465	nmod	Crx,photoreceptors
R2090	T3465	T3463	pobj	photoreceptors,to
R2091	T3466	T3464	punct	-,Crx
R2092	T3467	T3464	punct	/,Crx
R2093	T3468	T3464	punct	-,Crx
R2094	T3469	T3470	punct	(,compare
R2095	T3470	T3448	parataxis	compare,appeared
R2096	T3471	T3472	compound	Figure,4F
R2097	T3472	T3470	dobj	4F,compare
R2098	T3473	T3470	prep	to,compare
R2099	T3474	T3475	compound	Figure,6A
R21	T139	T137	case	's,Leber
R2100	T3475	T3473	pobj	6A,to
R2101	T3476	T3475	cc	and,6A
R2102	T3477	T3475	conj	6B,6A
R2103	T3478	T3470	punct	),compare
R2104	T3479	T3448	punct	.,appeared
R2111	T3638	T3639	nsubj	Crx,is
R2112	T3640	T3639	acomp	necessary,is
R2113	T3641	T3640	prep	for,necessary
R2114	T3642	T3643	det	the,formation
R2115	T3643	T3641	pobj	formation,for
R2116	T3644	T3643	prep	of,formation
R2117	T3645	T3646	compound	photoreceptor,terminals
R2118	T3646	T3644	pobj	terminals,of
R2119	T3648	T3649	prep	In,demonstrated
R2120	T3650	T3651	det	a,study
R2121	T3651	T3648	pobj	study,In
R2122	T3652	T3651	amod	previous,study
R2123	T3653	T3649	punct	", ",demonstrated
R2124	T3654	T3649	nsubj	we,demonstrated
R2125	T3655	T3656	mark	that,blocked
R2126	T3656	T3649	ccomp	blocked,demonstrated
R2127	T3657	T3658	amod	forced,expression
R2128	T3658	T3656	nsubj	expression,blocked
R2129	T3659	T3658	prep	of,expression
R2130	T3660	T3661	det	a,allele
R2131	T3661	T3659	pobj	allele,of
R2132	T3662	T3663	amod	dominant,negative
R2133	T3663	T3661	amod	negative,allele
R2134	T3664	T3663	punct	-,negative
R2135	T3665	T3661	prep	of,allele
R2136	T3666	T3665	pobj	Crx,of
R2137	T3667	T3658	prep	in,expression
R2138	T3668	T3669	amod	developing,rods
R2139	T3669	T3667	pobj	rods,in
R2140	T3670	T3656	dobj	formation,blocked
R2141	T3671	T3670	prep	of,formation
R2142	T3672	T3673	det	both,spherules
R2143	T3673	T3671	pobj	spherules,of
R2144	T3674	T3673	compound	rod,spherules
R2145	T3675	T3656	prep	in,blocked
R2146	T3676	T3677	det	the,layer
R2147	T3677	T3675	pobj	layer,in
R2148	T3678	T3677	amod	outer,layer
R2149	T3679	T3677	compound	plexiform,layer
R2150	T3680	T3677	punct	(,layer
R2151	T3681	T3677	appos	OPL,layer
R2152	T3682	T3677	punct	),layer
R2153	T3683	T3677	cc	and,layer
R2154	T3684	T3685	amod	outer,segments
R2155	T3685	T3677	conj	segments,layer
R2156	T3686	T3687	punct	[,7
R2157	T3687	T3649	parataxis	7,demonstrated
R2158	T3688	T3687	punct	],7
R2159	T3689	T3649	punct	.,demonstrated
R2160	T3691	T3692	aux	To,expand
R2161	T3692	T3693	advcl	expand,examined
R2162	T3694	T3692	prep	on,expand
R2163	T3695	T3696	det	these,studies
R2164	T3696	T3694	pobj	studies,on
R2165	T3697	T3693	punct	", ",examined
R2166	T3698	T3699	det	the,ultrastructure
R2167	T3699	T3693	nsubjpass	ultrastructure,examined
R2168	T3700	T3699	prep	of,ultrastructure
R2169	T3701	T3702	compound	photoreceptor,synapses
R2170	T3702	T3700	pobj	synapses,of
R2171	T3703	T3693	auxpass	was,examined
R2172	T3704	T3693	prep	in,examined
R2173	T3705	T3706	nmod	Crx,retinas
R2174	T3706	T3704	pobj	retinas,in
R2175	T3707	T3705	punct	-,Crx
R2176	T3708	T3705	punct	/,Crx
R2177	T3709	T3705	punct	-,Crx
R2178	T3710	T3693	punct	.,examined
R2179	T3712	T3713	prep	In,were
R2180	T3714	T3715	nmod	Crx,retinas
R2181	T3715	T3712	pobj	retinas,In
R2182	T3716	T3714	punct	+,Crx
R2183	T3717	T3714	punct	/,Crx
R2184	T3718	T3714	punct	+,Crx
R2185	T3719	T3713	prep	at,were
R2186	T3720	T3719	pobj	P21,at
R2187	T3721	T3713	punct	", ",were
R2188	T3722	T3723	advmod	newly,mature
R2189	T3723	T3724	amod	mature,spherules
R2190	T3724	T3713	nsubj	spherules,were
R2191	T3725	T3724	compound	rod,spherules
R2192	T3726	T3713	acomp	abundant,were
R2193	T3727	T3728	punct	(,7A
R2194	T3728	T3713	parataxis	7A,were
R2195	T3729	T3728	compound	Figure,7A
R2196	T3730	T3728	punct	),7A
R2197	T3731	T3713	punct	.,were
R2198	T3733	T3734	det	The,sperules
R2199	T3734	T3735	nsubj	sperules,were
R22	T140	T138	amod	congenital,amaurosis
R220	T822	T823	compound	Photoreceptor,cells
R2200	T3736	T3737	amod	blunt,structures
R2201	T3737	T3735	attr	structures,were
R2202	T3738	T3736	cc	or,blunt
R2203	T3739	T3740	npadvmod	club,shaped
R2204	T3740	T3736	conj	shaped,blunt
R2205	T3741	T3740	punct	-,shaped
R2206	T3742	T3737	prep	with,structures
R2207	T3743	T3744	det	a,ribbon
R2208	T3744	T3742	pobj	ribbon,with
R2209	T3745	T3744	amod	single,ribbon
R221	T823	T824	nsubj	cells,play
R2210	T3746	T3744	acl	associated,ribbon
R2211	T3747	T3746	prep	with,associated
R2212	T3748	T3749	det	a,synapse
R2213	T3749	T3747	pobj	synapse,with
R2214	T3750	T3749	amod	single,synapse
R2215	T3751	T3749	amod	invaginating,synapse
R2216	T3752	T3753	punct	(,8A
R2217	T3753	T3735	parataxis	8A,were
R2218	T3754	T3755	compound	Figure,7A
R2219	T3755	T3753	dep	7A,8A
R222	T825	T826	det	a,role
R2220	T3756	T3753	punct	", ",8A
R2221	T3757	T3758	nsubj	arrow,indicates
R2222	T3758	T3753	ccomp	indicates,8A
R2223	T3759	T3760	nummod	one,example
R2224	T3760	T3758	dobj	example,indicates
R2225	T3761	T3753	punct	;,8A
R2226	T3762	T3753	compound	Figure,8A
R2227	T3763	T3753	cc	and,8A
R2228	T3764	T3753	conj	8B,8A
R2229	T3765	T3753	punct	),8A
R223	T826	T824	dobj	role,play
R2230	T3766	T3735	punct	.,were
R2231	T3768	T3769	nummod	Two,processes
R2232	T3769	T3770	nsubjpass	processes,situated
R2233	T3771	T3769	prep	from,processes
R2234	T3772	T3773	amod	horizontal,cells
R2235	T3773	T3771	pobj	cells,from
R2236	T3774	T3770	auxpass	were,situated
R2237	T3775	T3770	prep	on,situated
R2238	T3776	T3777	det	either,side
R2239	T3777	T3775	pobj	side,on
R224	T827	T826	amod	primary,role
R2240	T3778	T3777	prep	of,side
R2241	T3779	T3780	det	the,ridge
R2242	T3780	T3778	pobj	ridge,of
R2243	T3781	T3780	amod	synaptic,ridge
R2244	T3782	T3783	punct	(,8B
R2245	T3783	T3770	parataxis	8B,situated
R2246	T3784	T3783	compound	Figure,8B
R2247	T3785	T3783	punct	", ",8B
R2248	T3786	T3783	advcl	labelled,8B
R2249	T3787	T3786	ccomp	H,labelled
R225	T828	T824	prep	in,play
R2250	T3788	T3783	punct	),8B
R2251	T3789	T3770	cc	and,situated
R2252	T3790	T3791	nummod	one,dendrites
R2253	T3791	T3794	nsubj	dendrites,occupied
R2254	T3792	T3790	cc	or,one
R2255	T3793	T3790	conj	more,one
R2256	T3794	T3770	conj	occupied,situated
R2257	T3795	T3791	prep	of,dendrites
R2258	T3796	T3797	nmod	rod,cells
R2259	T3797	T3795	pobj	cells,of
R226	T829	T828	pobj	vision,in
R2260	T3798	T3797	amod	bipolar,cells
R2261	T3799	T3800	det	a,position
R2262	T3800	T3794	dobj	position,occupied
R2263	T3801	T3800	amod	central,position
R2264	T3802	T3803	punct	(,B
R2265	T3803	T3794	parataxis	B,occupied
R2266	T3804	T3805	compound	Figure,8B
R2267	T3805	T3803	dep	8B,B
R2268	T3806	T3803	punct	", ",B
R2269	T3807	T3808	amod	bipolar,labelled
R227	T830	T824	prep	by,play
R2270	T3808	T3803	amod	labelled,B
R2271	T3809	T3794	punct	),occupied
R2272	T3810	T3794	punct	.,occupied
R2273	T3812	T3813	compound	Cone,terminals
R2274	T3813	T3814	nsubj	terminals,are
R2275	T3815	T3816	amod	large,flat
R2276	T3816	T3818	amod	flat,pedicles
R2277	T3817	T3816	punct	", ",flat
R2278	T3818	T3814	attr	pedicles,are
R2279	T3819	T3820	dep	that,exhibit
R228	T831	T830	pcomp	capturing,by
R2280	T3820	T3818	relcl	exhibit,pedicles
R2281	T3821	T3822	amod	many,synapses
R2282	T3822	T3820	dobj	synapses,exhibit
R2283	T3823	T3822	amod	invaginating,synapses
R2284	T3824	T3822	acl	containing,synapses
R2285	T3825	T3826	amod	separate,sets
R2286	T3826	T3824	dobj	sets,containing
R2287	T3827	T3826	prep	of,sets
R2288	T3828	T3829	amod	horizontal,processes
R2289	T3829	T3827	pobj	processes,of
R229	T832	T833	compound	light,energy
R2290	T3830	T3828	cc	and,horizontal
R2291	T3831	T3828	conj	bipolar,horizontal
R2292	T3832	T3829	compound	cell,processes
R2293	T3833	T3814	punct	.,are
R2294	T3835	T3836	det	Each,pedicle
R2295	T3836	T3837	nsubj	pedicle,contains
R2296	T3838	T3839	amod	numerous,ribbons
R2297	T3839	T3837	dobj	ribbons,contains
R2298	T3840	T3837	punct	.,contains
R2299	T3842	T3843	det	These,terminals
R23	T141	T138	punct	(,amaurosis
R230	T833	T831	dobj	energy,capturing
R2300	T3843	T3844	nsubj	terminals,were
R2301	T3845	T3846	advmod	much,less
R2302	T3846	T3847	advmod	less,common
R2303	T3847	T3844	acomp	common,were
R2304	T3848	T3847	prep	than,common
R2305	T3849	T3848	pobj	spherules,than
R2306	T3850	T3849	prep	in,spherules
R2307	T3851	T3852	nmod	Crx,retinas
R2308	T3852	T3850	pobj	retinas,in
R2309	T3853	T3851	punct	+,Crx
R231	T834	T831	cc	and,capturing
R2310	T3854	T3851	punct	/,Crx
R2311	T3855	T3851	punct	+,Crx
R2312	T3856	T3849	prep	at,spherules
R2313	T3857	T3856	pobj	P21,at
R2314	T3858	T3859	punct	(,box
R2315	T3859	T3844	parataxis	box,were
R2316	T3860	T3859	dep	Figure,box
R2317	T3861	T3860	nummod	7,Figure
R2318	T3862	T3859	punct	", ",box
R2319	T3863	T3859	punct	),box
R232	T835	T831	conj	converting,capturing
R2320	T3864	T3844	punct	.,were
R2321	T3866	T3867	prep	In,were
R2322	T3868	T3869	det	the,OPL
R2323	T3869	T3866	pobj	OPL,In
R2324	T3870	T3869	prep	of,OPL
R2325	T3871	T3872	nmod	Crx,retinas
R2326	T3872	T3870	pobj	retinas,of
R2327	T3873	T3871	punct	-,Crx
R2328	T3874	T3871	punct	/,Crx
R2329	T3875	T3871	punct	-,Crx
R233	T836	T835	dobj	it,converting
R2330	T3876	T3867	punct	", ",were
R2331	T3877	T3878	compound	photoreceptor,terminals
R2332	T3878	T3867	nsubj	terminals,were
R2333	T3879	T3880	advmod	highly,disorganized
R2334	T3880	T3867	acomp	disorganized,were
R2335	T3881	T3867	prep	at,were
R2336	T3882	T3881	pobj	P21,at
R2337	T3883	T3884	punct	(,arrows
R2338	T3884	T3867	parataxis	arrows,were
R2339	T3885	T3886	compound	Figure,7B
R234	T837	T835	prep	into,converting
R2340	T3886	T3884	dep	7B,arrows
R2341	T3887	T3884	punct	", ",arrows
R2342	T3888	T3884	punct	),arrows
R2343	T3889	T3867	punct	.,were
R2344	T3891	T3892	nsubj	Processes,were
R2345	T3893	T3891	acl	containing,Processes
R2346	T3894	T3895	amod	synaptic,vesicles
R2347	T3895	T3893	dobj	vesicles,containing
R2348	T3896	T3895	cc	and,vesicles
R2349	T3897	T3898	npadvmod	ribbon,like
R235	T838	T839	amod	neural,stimuli
R2350	T3898	T3900	amod	like,structures
R2351	T3899	T3898	punct	-,like
R2352	T3900	T3895	conj	structures,vesicles
R2353	T3901	T3892	acomp	apparent,were
R2354	T3902	T3892	punct	", ",were
R2355	T3903	T3892	advcl	suggesting,were
R2356	T3904	T3905	advmod	at,least
R2357	T3905	T3906	advmod	least,limited
R2358	T3906	T3907	amod	limited,generation
R2359	T3907	T3903	dobj	generation,suggesting
R236	T839	T837	pobj	stimuli,into
R2360	T3908	T3907	prep	of,generation
R2361	T3909	T3910	compound	synapse,components
R2362	T3910	T3908	pobj	components,of
R2363	T3911	T3892	punct	.,were
R2364	T3913	T3914	advmod	However,observed
R2365	T3915	T3914	punct	", ",observed
R2366	T3916	T3917	advmod	well,formed
R2367	T3917	T3918	amod	formed,spherules
R2368	T3918	T3914	nsubjpass	spherules,observed
R2369	T3919	T3918	cc	and,spherules
R237	T840	T824	punct	.,play
R2370	T3920	T3918	conj	pedicles,spherules
R2371	T3921	T3914	auxpass	were,observed
R2372	T3922	T3914	neg	not,observed
R2373	T3923	T3914	punct	.,observed
R2374	T3925	T3926	prep	In,appeared
R2375	T3927	T3925	pobj	addition,In
R2376	T3928	T3926	punct	", ",appeared
R2377	T3929	T3930	amod	many,terminals
R2378	T3930	T3926	nsubj	terminals,appeared
R2379	T3931	T3932	aux	to,contain
R238	T842	T843	det	These,neurons
R2380	T3932	T3926	xcomp	contain,appeared
R2381	T3933	T3934	amod	multiple,ribbons
R2382	T3934	T3932	dobj	ribbons,contain
R2383	T3935	T3936	punct	(,r
R2384	T3936	T3934	parataxis	r,ribbons
R2385	T3937	T3938	compound	Figure,8C
R2386	T3938	T3936	dep	8C,r
R2387	T3939	T3938	cc	and,8C
R2388	T3940	T3938	conj	8D,8C
R2389	T3941	T3936	punct	", ",r
R239	T843	T845	nsubj	neurons,are
R2390	T3942	T3936	punct	),r
R2391	T3943	T3944	neg	not,tethered
R2392	T3944	T3934	acl	tethered,ribbons
R2393	T3945	T3944	prep	to,tethered
R2394	T3946	T3947	det	the,membrane
R2395	T3947	T3945	pobj	membrane,to
R2396	T3948	T3947	compound	plasma,membrane
R2397	T3949	T3944	cc	and,tethered
R2398	T3950	T3951	advmod	occasionally,in
R2399	T3951	T3944	conj	in,tethered
R24	T142	T138	appos	LCA,amaurosis
R240	T844	T843	amod	sensory,neurons
R2400	T3952	T3953	amod	perinuclear,positions
R2401	T3953	T3951	pobj	positions,in
R2402	T3954	T3955	punct	(,8D
R2403	T3955	T3932	parataxis	8D,contain
R2404	T3956	T3955	compound	Figure,8D
R2405	T3957	T3955	punct	),8D
R2406	T3958	T3926	punct	.,appeared
R2407	T4008	T4009	prep	In,carried
R2408	T4010	T4011	det	this,study
R2409	T4011	T4008	pobj	study,In
R241	T846	T847	det	a,element
R2410	T4012	T4009	punct	", ",carried
R2411	T4013	T4014	det	an,analysis
R2412	T4014	T4009	nsubjpass	analysis,carried
R2413	T4015	T4014	amod	ultrastructural,analysis
R2414	T4016	T4014	prep	of,analysis
R2415	T4017	T4018	nmod	Crx,photoreceptors
R2416	T4018	T4016	pobj	photoreceptors,of
R2417	T4019	T4017	punct	-,Crx
R2418	T4020	T4017	punct	/,Crx
R2419	T4021	T4017	punct	-,Crx
R242	T847	T845	attr	element,are
R2420	T4022	T4009	auxpass	was,carried
R2421	T4023	T4009	prt	out,carried
R2422	T4024	T4009	punct	.,carried
R2423	T4026	T4027	mark	As,associated
R2424	T4027	T4032	advcl	associated,broaden
R2425	T4028	T4029	compound	Crx,mutations
R2426	T4029	T4027	nsubjpass	mutations,associated
R2427	T4030	T4027	aux	have,associated
R2428	T4031	T4027	auxpass	been,associated
R2429	T4033	T4027	prep	with,associated
R243	T848	T847	amod	shared,element
R2430	T4034	T4035	poss	Leber,amaurosis
R2431	T4035	T4033	pobj	amaurosis,with
R2432	T4036	T4034	case	's,Leber
R2433	T4037	T4035	amod	congenital,amaurosis
R2434	T4038	T4032	punct	", ",broaden
R2435	T4039	T4040	det	the,findings
R2436	T4040	T4032	nsubj	findings,broaden
R2437	T4041	T4040	prep	in,findings
R2438	T4042	T4043	det	this,study
R2439	T4043	T4041	pobj	study,in
R244	T849	T845	prep	in,are
R2440	T4044	T4045	poss	our,understanding
R2441	T4045	T4032	dobj	understanding,broaden
R2442	T4046	T4045	prep	of,understanding
R2443	T4047	T4048	det	the,pathology
R2444	T4048	T4046	pobj	pathology,of
R2445	T4049	T4048	prep	of,pathology
R2446	T4050	T4051	det	this,disease
R2447	T4051	T4049	pobj	disease,of
R2448	T4052	T4032	punct	.,broaden
R2449	T4054	T4055	nummod	Two,pathologies
R245	T850	T851	det	all,organisms
R2450	T4055	T4057	nsubjpass	pathologies,characterized
R2451	T4056	T4055	amod	prominent,pathologies
R2452	T4057	T4059	ccomp	characterized,exhibited
R2453	T4058	T4057	auxpass	were,characterized
R2454	T4060	T4057	prep	in,characterized
R2455	T4061	T4062	det	the,retina
R2456	T4062	T4060	pobj	retina,in
R2457	T4063	T4062	nmod	Crx,retina
R2458	T4064	T4063	punct	-,Crx
R2459	T4065	T4063	punct	/,Crx
R246	T851	T849	pobj	organisms,in
R2460	T4066	T4063	punct	-,Crx
R2461	T4067	T4059	punct	: ,exhibited
R2462	T4068	T4069	punct	(,1
R2463	T4069	T4070	meta	1,noted
R2464	T4070	T4059	ccomp	noted,exhibited
R2465	T4071	T4069	punct	),1
R2466	T4072	T4073	det	An,block
R2467	T4073	T4070	nsubjpass	block,noted
R2468	T4074	T4073	amod	absolute,block
R2469	T4075	T4073	prep	in,block
R247	T852	T851	amod	capable,organisms
R2470	T4076	T4077	amod	outer,segment
R2471	T4077	T4078	compound	segment,morphogenesis
R2472	T4078	T4075	pobj	morphogenesis,in
R2473	T4079	T4070	auxpass	was,noted
R2474	T4080	T4070	punct	", ",noted
R2475	T4081	T4070	prep	with,noted
R2476	T4082	T4083	det	the,block
R2477	T4083	T4084	nsubj	block,occuring
R2478	T4084	T4081	pcomp	occuring,with
R2479	T4085	T4084	prep	at,occuring
R248	T853	T852	prep	of,capable
R2480	T4086	T4087	det	the,stage
R2481	T4087	T4085	pobj	stage,at
R2482	T4088	T4087	compound	elongation,stage
R2483	T4089	T4087	prep	of,stage
R2484	T4090	T4091	amod	outer,segment
R2485	T4091	T4092	compound	segment,formation
R2486	T4092	T4089	pobj	formation,of
R2487	T4093	T4059	punct	;,exhibited
R2488	T4094	T4095	punct	(,2
R2489	T4095	T4059	meta	2,exhibited
R249	T854	T853	pcomp	sensing,of
R2490	T4096	T4095	punct	),2
R2491	T4097	T4098	nmod	Crx,photoreceptors
R2492	T4098	T4059	nsubj	photoreceptors,exhibited
R2493	T4099	T4097	punct	-,Crx
R2494	T4100	T4097	punct	/,Crx
R2495	T4101	T4097	punct	-,Crx
R2496	T4102	T4103	det	a,perturbation
R2497	T4103	T4059	dobj	perturbation,exhibited
R2498	T4104	T4103	amod	severe,perturbation
R2499	T4105	T4103	prep	in,perturbation
R25	T143	T136	punct	),are
R250	T855	T854	dobj	light,sensing
R2500	T4106	T4107	compound	synapse,formation
R2501	T4107	T4105	pobj	formation,in
R2502	T4108	T4059	punct	.,exhibited
R2503	T4110	T4111	nsubj	This,represents
R2504	T4112	T4113	det	the,report
R2505	T4113	T4111	dobj	report,represents
R2506	T4114	T4113	amod	first,report
R2507	T4115	T4113	prep	of,report
R2508	T4116	T4117	det	a,defect
R2509	T4117	T4115	pobj	defect,of
R251	T856	T845	punct	.,are
R2510	T4118	T4117	compound	synaptogenesis,defect
R2511	T4119	T4117	prep	in,defect
R2512	T4120	T4121	det	an,model
R2513	T4121	T4119	pobj	model,in
R2514	T4122	T4121	compound	animal,model
R2515	T4123	T4121	prep	of,model
R2516	T4124	T4123	pobj	LCA,of
R2517	T4125	T4111	punct	.,represents
R252	T858	T859	prep	In,are
R2524	T4696	T4697	nmod	Crx,photoreceptors
R2525	T4697	T4701	nsubj	photoreceptors,complete
R2526	T4698	T4696	punct	-,Crx
R2527	T4699	T4696	punct	/,Crx
R2528	T4700	T4696	punct	-,Crx
R2529	T4702	T4701	aux	can,complete
R253	T860	T858	pobj	humans,In
R2530	T4703	T4701	neg	not,complete
R2531	T4704	T4705	amod	outer,segment
R2532	T4705	T4706	compound	segment,morphogenesis
R2533	T4706	T4701	dobj	morphogenesis,complete
R2534	T4708	T4709	nsubj	Mutations,represent
R2535	T4710	T4708	prep	in,Mutations
R2536	T4711	T4710	pobj	Crx,in
R2537	T4712	T4709	dobj	one,represent
R2538	T4713	T4712	prep	of,one
R2539	T4714	T4715	det	a,collection
R254	T861	T859	punct	", ",are
R2540	T4715	T4713	pobj	collection,of
R2541	T4716	T4715	prep	of,collection
R2542	T4717	T4718	compound	gene,mutations
R2543	T4718	T4716	pobj	mutations,of
R2544	T4719	T4720	dep	that,lead
R2545	T4720	T4718	relcl	lead,mutations
R2546	T4721	T4720	prep	to,lead
R2547	T4722	T4723	det	an,defect
R2548	T4723	T4721	pobj	defect,to
R2549	T4724	T4725	amod	outer,segment
R255	T862	T863	amod	genetic,diseases
R2550	T4725	T4723	compound	segment,defect
R2551	T4726	T4723	compound	formation,defect
R2552	T4727	T4709	punct	.,represent
R2553	T4729	T4730	amod	Homozygous,mutations
R2554	T4730	T4732	nsubj	mutations,lead
R2555	T4731	T4730	amod	null,mutations
R2556	T4733	T4730	prep	in,mutations
R2557	T4734	T4735	det	the,gene
R2558	T4735	T4733	pobj	gene,in
R2559	T4736	T4737	compound	peripherin,RDS
R256	T863	T859	nsubj	diseases,are
R2560	T4737	T4735	compound	RDS,gene
R2561	T4738	T4737	punct	/,RDS
R2562	T4739	T4740	punct	[,36
R2563	T4740	T4735	parataxis	36,gene
R2564	T4741	T4740	punct	],36
R2565	T4742	T4733	cc	or,in
R2566	T4743	T4733	conj	in,in
R2567	T4744	T4743	pobj	rhodopsin,in
R2568	T4745	T4746	punct	[,29
R2569	T4746	T4744	parataxis	29,rhodopsin
R257	T864	T863	prep	of,diseases
R2570	T4747	T4746	punct	],29
R2571	T4748	T4732	prep	to,lead
R2572	T4749	T4750	det	a,failure
R2573	T4750	T4748	pobj	failure,to
R2574	T4751	T4750	prep	of,failure
R2575	T4752	T4753	amod	outer,segment
R2576	T4753	T4754	compound	segment,formation
R2577	T4754	T4751	pobj	formation,of
R2578	T4755	T4732	punct	.,lead
R2579	T4757	T4758	det	The,deficits
R258	T865	T866	det	the,eye
R2580	T4758	T4759	nsubjpass	deficits,found
R2581	T4760	T4758	prep	in,deficits
R2582	T4761	T4762	nmod	peripherin,morphogenesis
R2583	T4762	T4760	pobj	morphogenesis,in
R2584	T4763	T4761	punct	-,peripherin
R2585	T4764	T4761	punct	/,peripherin
R2586	T4765	T4761	punct	-,peripherin
R2587	T4766	T4761	cc	and,peripherin
R2588	T4767	T4761	conj	Crx,peripherin
R2589	T4768	T4767	punct	-,Crx
R259	T866	T864	pobj	eye,of
R2590	T4769	T4767	punct	/,Crx
R2591	T4770	T4767	punct	-,Crx
R2592	T4771	T4762	compound	photoreceptor,morphogenesis
R2593	T4772	T4759	auxpass	were,found
R2594	T4773	T4774	aux	to,be
R2595	T4774	T4759	xcomp	be,found
R2596	T4775	T4776	advmod	very,similar
R2597	T4776	T4774	acomp	similar,be
R2598	T4777	T4759	punct	.,found
R2599	T4779	T4780	amod	Vesicular,structures
R26	T144	T136	punct	", ",are
R260	T867	T859	acomp	common,are
R2600	T4780	T4781	nsubjpass	structures,observed
R2601	T4782	T4780	prep	in,structures
R2602	T4783	T4784	nmod	Crx,photoreceptors
R2603	T4784	T4782	pobj	photoreceptors,in
R2604	T4785	T4783	punct	-,Crx
R2605	T4786	T4783	punct	/,Crx
R2606	T4787	T4783	punct	-,Crx
R2607	T4788	T4781	auxpass	were,observed
R2608	T4789	T4790	dep	that,were
R2609	T4790	T4781	ccomp	were,observed
R261	T868	T859	cc	and,are
R2610	T4791	T4790	acomp	similar,were
R2611	T4792	T4791	prep	to,similar
R2612	T4793	T4792	pobj	those,to
R2613	T4794	T4795	advmod	previously,noted
R2614	T4795	T4793	acl	noted,those
R2615	T4796	T4795	prep	in,noted
R2616	T4797	T4798	det	the,mouse
R2617	T4798	T4796	pobj	mouse,in
R2618	T4799	T4800	nmod	rds,peripherin
R2619	T4800	T4798	nmod	peripherin,mouse
R262	T869	T870	det	the,site
R2620	T4801	T4800	punct	/,peripherin
R2621	T4802	T4800	punct	-,peripherin
R2622	T4803	T4800	punct	/,peripherin
R2623	T4804	T4800	punct	-,peripherin
R2624	T4805	T4781	punct	.,observed
R2625	T4807	T4808	nsubjpass	It,proposed
R2626	T4809	T4808	auxpass	was,proposed
R2627	T4810	T4808	advmod	initially,proposed
R2628	T4811	T4812	mark	that,were
R2629	T4812	T4808	ccomp	were,proposed
R263	T870	T872	nsubj	site,is
R2630	T4813	T4814	det	these,vesicles
R2631	T4814	T4812	nsubj	vesicles,were
R2632	T4815	T4812	prep	due,were
R2633	T4816	T4815	pcomp	to,due
R2634	T4817	T4818	det	the,breakdown
R2635	T4818	T4815	pobj	breakdown,due
R2636	T4819	T4818	prep	of,breakdown
R2637	T4820	T4821	amod	outer,segment
R2638	T4821	T4822	compound	segment,membranes
R2639	T4822	T4819	pobj	membranes,of
R264	T871	T870	amod	primary,site
R2640	T4823	T4824	dep	that,recruited
R2641	T4824	T4822	relcl	recruited,membranes
R2642	T4825	T4824	auxpass	were,recruited
R2643	T4826	T4824	neg	not,recruited
R2644	T4827	T4824	advmod	properly,recruited
R2645	T4828	T4824	prep	to,recruited
R2646	T4829	T4830	det	the,segments
R2647	T4830	T4828	pobj	segments,to
R2648	T4831	T4830	amod	outer,segments
R2649	T4832	T4824	prep	in,recruited
R265	T872	T859	conj	is,are
R2650	T4833	T4834	det	the,absence
R2651	T4834	T4832	pobj	absence,in
R2652	T4835	T4834	prep	of,absence
R2653	T4836	T4835	pobj	peripherin,of
R2654	T4837	T4812	punct	", ",were
R2655	T4838	T4812	cc	or,were
R2656	T4839	T4812	conj	were,were
R2657	T4840	T4839	prep	from,were
R2658	T4841	T4842	det	the,result
R2659	T4842	T4840	pobj	result,from
R266	T873	T870	prep	of,site
R2660	T4843	T4842	prep	of,result
R2661	T4844	T4845	det	the,breakdown
R2662	T4845	T4843	pobj	breakdown,of
R2663	T4846	T4845	prep	of,breakdown
R2664	T4847	T4848	det	the,microvilli
R2665	T4848	T4846	pobj	microvilli,of
R2666	T4849	T4848	prep	of,microvilli
R2667	T4850	T4851	compound	Müller,cells
R2668	T4851	T4849	pobj	cells,of
R2669	T4852	T4853	punct	[,30
R267	T874	T873	pobj	disease,of
R2670	T4853	T4839	parataxis	30,were
R2671	T4854	T4853	punct	],30
R2672	T4855	T4808	punct	.,proposed
R2673	T4857	T4858	amod	Strong,support
R2674	T4858	T4859	nsubjpass	support,provided
R2675	T4860	T4858	prep	in,support
R2676	T4861	T4860	pobj	favor,in
R2677	T4862	T4861	prep	of,favor
R2678	T4863	T4864	det	the,explanation
R2679	T4864	T4862	pobj	explanation,of
R268	T875	T876	advmod	most,frequently
R2680	T4865	T4864	amod	former,explanation
R2681	T4866	T4859	auxpass	was,provided
R2682	T4867	T4859	agent	by,provided
R2683	T4868	T4867	pobj	Nir,by
R2684	T4869	T4868	cc	and,Nir
R2685	T4870	T4868	conj	colleagues,Nir
R2686	T4871	T4872	dep	who,demonstrated
R2687	T4872	T4868	relcl	demonstrated,Nir
R2688	T4873	T4874	det	the,presence
R2689	T4874	T4872	dobj	presence,demonstrated
R269	T876	T872	advmod	frequently,is
R2690	T4875	T4874	prep	of,presence
R2691	T4876	T4877	compound	rhodopsin,protein
R2692	T4877	T4875	pobj	protein,of
R2693	T4878	T4874	prep	in,presence
R2694	T4879	T4880	det	these,vesicles
R2695	T4880	T4878	pobj	vesicles,in
R2696	T4881	T4872	advcl	using,demonstrated
R2697	T4882	T4883	compound	immunoelectron,microscopy
R2698	T4883	T4881	dobj	microscopy,using
R2699	T4884	T4881	prep	against,using
R27	T145	T146	amod	affected,individuals
R270	T877	T872	attr	photoreceptors,is
R2700	T4885	T4886	det	a,epitope
R2701	T4886	T4884	pobj	epitope,against
R2702	T4887	T4886	compound	rhodopsin,epitope
R2703	T4888	T4889	punct	[,37
R2704	T4889	T4872	parataxis	37,demonstrated
R2705	T4890	T4889	punct	],37
R2706	T4891	T4859	punct	.,provided
R2707	T4893	T4894	advmod	Further,appear
R2708	T4895	T4894	punct	", ",appear
R2709	T4896	T4897	mark	as,shown
R271	T878	T879	punct	(,see
R2710	T4897	T4894	advcl	shown,appear
R2711	T4898	T4897	advmod	here,shown
R2712	T4899	T4894	punct	", ",appear
R2713	T4900	T4901	det	the,vesicles
R2714	T4901	T4894	nsubj	vesicles,appear
R2715	T4902	T4903	aux	to,bud
R2716	T4903	T4894	xcomp	bud,appear
R2717	T4904	T4903	prep	from,bud
R2718	T4905	T4906	det	the,segments
R2719	T4906	T4904	pobj	segments,from
R272	T879	T872	parataxis	see,is
R2720	T4907	T4906	amod	inner,segments
R2721	T4908	T4906	appos	themselves,segments
R2722	T4909	T4894	punct	.,appear
R2723	T4911	T4912	prep	In,occurs
R2724	T4913	T4914	amod	developing,photoreceptors
R2725	T4914	T4911	pobj	photoreceptors,In
R2726	T4915	T4912	punct	", ",occurs
R2727	T4916	T4917	det	an,process
R2728	T4917	T4912	nsubj	process,occurs
R2729	T4918	T4917	amod	extraordinary,process
R273	T880	T879	prep	for,see
R2730	T4919	T4917	compound	growth,process
R2731	T4920	T4921	advmod	whereby,generated
R2732	T4921	T4912	ccomp	generated,occurs
R2733	T4922	T4923	det	the,segment
R2734	T4923	T4921	nsubjpass	segment,generated
R2735	T4924	T4923	amod	outer,segment
R2736	T4925	T4921	auxpass	is,generated
R2737	T4926	T4921	prep	from,generated
R2738	T4927	T4928	det	the,cilium
R2739	T4928	T4926	pobj	cilium,from
R274	T881	T880	pobj	review,for
R2740	T4929	T4928	amod	nascent,cilium
R2741	T4930	T4928	amod	connecting,cilium
R2742	T4931	T4932	punct	(,see
R2743	T4932	T4912	parataxis	see,occurs
R2744	T4933	T4934	punct	[,38
R2745	T4934	T4932	dobj	38,see
R2746	T4935	T4934	punct	],38
R2747	T4936	T4934	cc	and,38
R2748	T4937	T4934	conj	references,38
R2749	T4938	T4937	advmod	therein,references
R275	T882	T879	punct	[,see
R2750	T4939	T4932	punct	),see
R2751	T4940	T4912	punct	.,occurs
R2752	T4942	T4943	nmod	Peripherin,RDS
R2753	T4943	T4945	nmod	RDS,proteins
R2754	T4944	T4943	punct	/,RDS
R2755	T4945	T4950	nsubj	proteins,have
R2756	T4946	T4943	cc	and,RDS
R2757	T4947	T4943	conj	ROM,RDS
R2758	T4948	T4947	punct	-,ROM
R2759	T4949	T4947	nummod	1,ROM
R276	T883	T879	dobj	1,see
R2760	T4951	T4945	punct	(,proteins
R2761	T4952	T4945	acl	localized,proteins
R2762	T4953	T4952	prep	in,localized
R2763	T4954	T4955	compound	disc,rims
R2764	T4955	T4953	pobj	rims,in
R2765	T4956	T4945	punct	),proteins
R2766	T4957	T4945	cc	and,proteins
R2767	T4958	T4959	det	the,proteins
R2768	T4959	T4945	conj	proteins,proteins
R2769	T4960	T4959	compound	opsin,proteins
R277	T884	T885	punct	-,3
R2770	T4961	T4959	punct	(,proteins
R2771	T4962	T4959	acl	localized,proteins
R2772	T4963	T4962	prep	throughout,localized
R2773	T4964	T4965	det	the,discs
R2774	T4965	T4963	pobj	discs,throughout
R2775	T4966	T4950	punct	),have
R2776	T4967	T4968	amod	important,roles
R2777	T4968	T4950	dobj	roles,have
R2778	T4969	T4968	prep	in,roles
R2779	T4970	T4971	det	the,integrity
R278	T885	T883	prep	3,1
R2780	T4971	T4969	pobj	integrity,in
R2781	T4972	T4971	amod	structural,integrity
R2782	T4973	T4971	prep	of,integrity
R2783	T4974	T4975	amod	mature,segments
R2784	T4975	T4973	pobj	segments,of
R2785	T4976	T4975	amod	outer,segments
R2786	T4977	T4978	punct	(,see
R2787	T4978	T4950	parataxis	see,have
R2788	T4979	T4978	punct	[,see
R2789	T4980	T4981	nummod	39,29
R279	T886	T879	punct	],see
R2790	T4981	T4978	dobj	29,see
R2791	T4982	T4981	punct	",",29
R2792	T4983	T4978	punct	],see
R2793	T4984	T4978	punct	),see
R2794	T4985	T4950	punct	.,have
R2795	T4987	T4988	nmod	ROM,mice
R2796	T4988	T4994	nsubj	mice,produce
R2797	T4989	T4987	punct	-,ROM
R2798	T4990	T4987	nummod	1,ROM
R2799	T4991	T4987	punct	-,ROM
R28	T146	T136	nsubj	individuals,are
R280	T887	T879	punct	),see
R2800	T4992	T4987	punct	/,ROM
R2801	T4993	T4987	punct	-,ROM
R2802	T4995	T4996	amod	disorganized,segments
R2803	T4996	T4994	dobj	segments,produce
R2804	T4997	T4996	amod	outer,segments
R2805	T4998	T4996	prep	with,segments
R2806	T4999	T5000	amod	large,disks
R2807	T5000	T4998	pobj	disks,with
R2808	T5001	T5002	punct	[,40
R2809	T5002	T4994	parataxis	40,produce
R281	T888	T859	punct	.,are
R2810	T5003	T5002	punct	],40
R2811	T5004	T4994	punct	.,produce
R2812	T5006	T5007	nsubj	Crx,controls
R2813	T5008	T5007	punct	", ",controls
R2814	T5009	T5007	prep	by,controls
R2815	T5010	T5009	pobj	virtue,by
R2816	T5011	T5010	prep	of,virtue
R2817	T5012	T5011	pcomp	being,of
R2818	T5013	T5014	det	a,factor
R2819	T5014	T5012	attr	factor,being
R282	T890	T891	nsubjpass	Photoreceptors,studied
R2820	T5015	T5014	compound	transcription,factor
R2821	T5016	T5007	punct	", ",controls
R2822	T5017	T5007	advmod	presumably,controls
R2823	T5018	T5007	dobj	genes,controls
R2824	T5019	T5020	dep	that,are
R2825	T5020	T5018	relcl	are,genes
R2826	T5021	T5020	acomp	responsible,are
R2827	T5022	T5021	prep	for,responsible
R2828	T5023	T5024	det	the,building
R2829	T5024	T5022	pobj	building,for
R283	T892	T891	aux	have,studied
R2830	T5025	T5024	cc	and,building
R2831	T5026	T5027	advmod	perhaps,maintenance
R2832	T5027	T5024	conj	maintenance,building
R2833	T5028	T5024	prep	of,building
R2834	T5029	T5030	det	the,structure
R2835	T5030	T5028	pobj	structure,of
R2836	T5031	T5032	amod	outer,segment
R2837	T5032	T5030	compound	segment,structure
R2838	T5033	T5018	punct	", ",genes
R2839	T5034	T5018	prep	including,genes
R284	T893	T891	auxpass	been,studied
R2840	T5035	T5034	pobj	rhodopsin,including
R2841	T5036	T5035	cc	and,rhodopsin
R2842	T5037	T5035	conj	peripherin,rhodopsin
R2843	T5038	T5007	punct	.,controls
R2844	T5040	T5041	advcl	Using,defined
R2845	T5042	T5043	compound	northern,blots
R2846	T5043	T5040	dobj	blots,Using
R2847	T5044	T5045	punct	[,34
R2848	T5045	T5043	parataxis	34,blots
R2849	T5046	T5045	punct	],34
R285	T894	T891	advmod	well,studied
R2850	T5047	T5043	punct	", ",blots
R2851	T5048	T5043	conj	microarrays,blots
R2852	T5049	T5050	punct	[,10
R2853	T5050	T5048	parataxis	10,microarrays
R2854	T5051	T5050	punct	],10
R2855	T5052	T5048	punct	", ",microarrays
R2856	T5053	T5048	cc	and,microarrays
R2857	T5054	T5055	amod	serial,analysis
R2858	T5055	T5048	conj	analysis,microarrays
R2859	T5056	T5055	prep	of,analysis
R286	T895	T891	punct	", ",studied
R2860	T5057	T5058	compound	gene,expression
R2861	T5058	T5056	pobj	expression,of
R2862	T5059	T5055	punct	(,analysis
R2863	T5060	T5055	appos	SAGE,analysis
R2864	T5061	T5055	punct	),analysis
R2865	T5062	T5063	punct	[,35
R2866	T5063	T5055	parataxis	35,analysis
R2867	T5064	T5063	punct	],35
R2868	T5065	T5041	punct	", ",defined
R2869	T5066	T5041	nsubj	we,defined
R287	T896	T897	advmod	particularly,with
R2870	T5067	T5041	aux	have,defined
R2871	T5068	T5069	det	a,number
R2872	T5069	T5041	dobj	number,defined
R2873	T5070	T5069	amod	large,number
R2874	T5071	T5069	prep	of,number
R2875	T5072	T5071	pobj	genes,of
R2876	T5073	T5074	dep	that,altered
R2877	T5074	T5072	relcl	altered,genes
R2878	T5075	T5074	auxpass	are,altered
R2879	T5076	T5074	prep	in,altered
R288	T897	T891	prep	with,studied
R2880	T5077	T5078	poss	their,level
R2881	T5078	T5076	pobj	level,in
R2882	T5079	T5078	compound	expression,level
R2883	T5080	T5074	prep	in,altered
R2884	T5081	T5082	nmod	Crx,mice
R2885	T5082	T5080	pobj	mice,in
R2886	T5083	T5081	punct	-,Crx
R2887	T5084	T5081	punct	/,Crx
R2888	T5085	T5081	punct	-,Crx
R2889	T5086	T5041	punct	.,defined
R289	T898	T897	pobj	respect,with
R2890	T5088	T5089	nsubj	We,found
R2891	T5090	T5091	mark	that,diminished
R2892	T5091	T5089	ccomp	diminished,found
R2893	T5092	T5093	compound	rhodopsin,expression
R2894	T5093	T5091	nsubjpass	expression,diminished
R2895	T5094	T5091	auxpass	was,diminished
R2896	T5095	T5091	advmod	severely,diminished
R2897	T5096	T5091	prep	in,diminished
R2898	T5097	T5098	nmod	Crx,animals
R2899	T5098	T5096	pobj	animals,in
R29	T147	T136	acomp	blind,are
R290	T899	T898	prep	to,respect
R2900	T5099	T5097	punct	-,Crx
R2901	T5100	T5097	punct	/,Crx
R2902	T5101	T5097	punct	-,Crx
R2903	T5102	T5091	punct	", ",diminished
R2904	T5103	T5091	cc	and,diminished
R2905	T5104	T5105	compound	peripherin,mRNA
R2906	T5105	T5106	nsubjpass	mRNA,reduced
R2907	T5106	T5091	conj	reduced,diminished
R2908	T5107	T5106	auxpass	was,reduced
R2909	T5108	T5106	prep	by,reduced
R291	T900	T901	det	the,biochemistry
R2910	T5109	T5110	advmod	approximately,30
R2911	T5110	T5111	nummod	30,%
R2912	T5111	T5108	pobj	%,by
R2913	T5112	T5089	punct	.,found
R2914	T5114	T5115	amod	Transgenic,mice
R2915	T5115	T5116	nsubj	mice,exhibit
R2916	T5117	T5115	prep	with,mice
R2917	T5118	T5119	amod	variable,levels
R2918	T5119	T5117	pobj	levels,with
R2919	T5120	T5119	prep	of,levels
R292	T901	T899	pobj	biochemistry,to
R2920	T5121	T5120	pobj	expression,of
R2921	T5122	T5121	prep	of,expression
R2922	T5123	T5124	amod	wild,type
R2923	T5124	T5125	compound	type,rhodopsin
R2924	T5125	T5122	pobj	rhodopsin,of
R2925	T5126	T5127	compound	rod,degeneration
R2926	T5127	T5116	dobj	degeneration,exhibit
R2927	T5128	T5129	punct	[,41
R2928	T5129	T5116	parataxis	41,exhibit
R2929	T5130	T5129	punct	],41
R293	T902	T901	cc	and,biochemistry
R2930	T5131	T5116	punct	", ",exhibit
R2931	T5132	T5116	advcl	indicating,exhibit
R2932	T5133	T5134	det	the,importance
R2933	T5134	T5132	dobj	importance,indicating
R2934	T5135	T5134	prep	of,importance
R2935	T5136	T5137	det	the,level
R2936	T5137	T5135	pobj	level,of
R2937	T5138	T5137	prep	of,level
R2938	T5139	T5140	compound	rhodopsin,expression
R2939	T5140	T5138	pobj	expression,of
R294	T903	T901	conj	physiology,biochemistry
R2940	T5141	T5116	punct	.,exhibit
R2941	T5143	T5144	prep	In,be
R2942	T5145	T5143	pobj	addition,In
R2943	T5146	T5144	punct	", ",be
R2944	T5147	T5148	det	the,timing
R2945	T5148	T5144	nsubj	timing,be
R2946	T5149	T5148	prep	of,timing
R2947	T5150	T5151	compound	rhodopsin,expression
R2948	T5151	T5149	pobj	expression,of
R2949	T5152	T5144	aux	may,be
R295	T904	T901	prep	of,biochemistry
R2950	T5153	T5154	advmod	very,important
R2951	T5154	T5144	acomp	important,be
R2952	T5155	T5144	punct	", ",be
R2953	T5156	T5157	mark	as,indicated
R2954	T5157	T5144	advcl	indicated,be
R2955	T5158	T5157	agent	by,indicated
R2956	T5159	T5158	pobj	studies,by
R2957	T5160	T5159	prep	in,studies
R2958	T5161	T5160	pobj	Drosophila,in
R2959	T5162	T5144	punct	.,be
R296	T905	T904	pobj	phototransduction,of
R2960	T5164	T5165	prep	In,expressed
R2961	T5166	T5164	pobj	Drosophila,In
R2962	T5167	T5165	punct	", ",expressed
R2963	T5168	T5165	nsubjpass	rhodopsin,expressed
R2964	T5169	T5170	punct	(,ninaE
R2965	T5170	T5168	parataxis	ninaE,rhodopsin
R2966	T5171	T5170	punct	),ninaE
R2967	T5172	T5165	auxpass	is,expressed
R2968	T5173	T5165	prep	in,expressed
R2969	T5174	T5175	compound	photoreceptors,R1
R297	T906	T891	punct	.,studied
R2970	T5175	T5173	pobj	R1,in
R2971	T5176	T5177	punct	–,R6
R2972	T5177	T5175	prep	R6,R1
R2973	T5178	T5165	punct	.,expressed
R2974	T5180	T5181	prep	In,fails
R2975	T5182	T5183	npadvmod	ninaE,null
R2976	T5183	T5184	amod	null,mutants
R2977	T5184	T5180	pobj	mutants,In
R2978	T5185	T5181	punct	", ",fails
R2979	T5186	T5187	det	the,rhabdomere
R298	T908	T909	nsubj	Insight,lagged
R2980	T5187	T5181	nsubj	rhabdomere,fails
R2981	T5188	T5187	punct	", ",rhabdomere
R2982	T5189	T5190	det	a,structure
R2983	T5190	T5187	appos	structure,rhabdomere
R2984	T5191	T5190	amod	analogous,structure
R2985	T5192	T5191	prep	to,analogous
R2986	T5193	T5194	nmod	vertebrate,segments
R2987	T5194	T5192	pobj	segments,to
R2988	T5195	T5194	amod	outer,segments
R2989	T5196	T5181	punct	", ",fails
R299	T910	T908	prep	into,Insight
R2990	T5197	T5198	aux	to,develop
R2991	T5198	T5181	xcomp	develop,fails
R2992	T5199	T5198	prep	in,develop
R2993	T5200	T5201	nmod	R1,photoreceptors
R2994	T5201	T5199	pobj	photoreceptors,in
R2995	T5202	T5203	punct	–,R6
R2996	T5203	T5200	prep	R6,R1
R2997	T5204	T5205	punct	[,42
R2998	T5205	T5198	parataxis	42,develop
R2999	T5206	T5205	punct	],42
R30	T148	T147	punct	", ",blind
R300	T911	T912	det	the,development
R3000	T5207	T5198	punct	", ",develop
R3001	T5208	T5198	advcl	reminiscent,develop
R3002	T5209	T5208	prep	of,reminiscent
R3003	T5210	T5211	det	the,situation
R3004	T5211	T5209	pobj	situation,of
R3005	T5212	T5211	prep	in,situation
R3006	T5213	T5214	nmod	rhodopsin,mice
R3007	T5214	T5212	pobj	mice,in
R3008	T5215	T5213	punct	-,rhodopsin
R3009	T5216	T5213	punct	/,rhodopsin
R301	T912	T910	pobj	development,into
R3010	T5217	T5213	punct	-,rhodopsin
R3011	T5218	T5219	punct	[,29
R3012	T5219	T5208	parataxis	29,reminiscent
R3013	T5220	T5219	punct	],29
R3014	T5221	T5181	punct	.,fails
R3015	T5223	T5224	det	An,experiment
R3016	T5224	T5226	nsubj	experiment,demonstrated
R3017	T5225	T5224	amod	intriguing,experiment
R3018	T5227	T5224	prep	by,experiment
R3019	T5228	T5227	pobj	Kumar,by
R302	T913	T912	prep	of,development
R3020	T5229	T5230	advmod	et,al.
R3021	T5230	T5228	advmod	al.,Kumar
R3022	T5231	T5232	punct	[,43
R3023	T5232	T5228	parataxis	43,Kumar
R3024	T5233	T5232	punct	],43
R3025	T5234	T5235	det	a,requirement
R3026	T5235	T5226	dobj	requirement,demonstrated
R3027	T5236	T5235	amod	temporal,requirement
R3028	T5237	T5235	prep	for,requirement
R3029	T5238	T5239	compound	rhodopsin,expression
R303	T914	T915	compound	vertebrate,photoreceptors
R3030	T5239	T5237	pobj	expression,for
R3031	T5240	T5235	prep	during,requirement
R3032	T5241	T5242	compound	rhabdomere,development
R3033	T5242	T5240	pobj	development,during
R3034	T5243	T5226	punct	.,demonstrated
R3035	T5245	T5246	prep	In,subjected
R3036	T5247	T5248	npadvmod	ninaE,null
R3037	T5248	T5249	amod	null,flies
R3038	T5249	T5245	pobj	flies,In
R3039	T5250	T5246	punct	", ",subjected
R304	T915	T913	pobj	photoreceptors,of
R3040	T5251	T5252	det	a,transgene
R3041	T5252	T5246	nsubjpass	transgene,subjected
R3042	T5253	T5252	compound	ninaE,transgene
R3043	T5254	T5252	prep	under,transgene
R3044	T5255	T5256	det	the,control
R3045	T5256	T5254	pobj	control,under
R3046	T5257	T5256	prep	of,control
R3047	T5258	T5259	det	a,promoter
R3048	T5259	T5257	pobj	promoter,of
R3049	T5260	T5261	compound	heat,shock
R305	T916	T909	punct	", ",lagged
R3050	T5261	T5259	compound	shock,promoter
R3051	T5262	T5246	auxpass	was,subjected
R3052	T5263	T5246	prep	to,subjected
R3053	T5264	T5265	amod	various,shifts
R3054	T5265	T5263	pobj	shifts,to
R3055	T5266	T5265	compound	temperature,shifts
R3056	T5267	T5246	prep	during,subjected
R3057	T5268	T5267	pobj	development,during
R3058	T5269	T5246	punct	.,subjected
R3059	T5271	T5272	compound	Heat,shock
R306	T917	T909	advmod	however,lagged
R3060	T5272	T5273	nsubj	shock,resulted
R3061	T5274	T5272	prep	during,shock
R3062	T5275	T5276	det	the,time
R3063	T5276	T5274	pobj	time,during
R3064	T5277	T5276	amod	normal,time
R3065	T5278	T5276	prep	of,time
R3066	T5279	T5280	compound	rhodopsin,onset
R3067	T5280	T5278	pobj	onset,of
R3068	T5281	T5273	prep	in,resulted
R3069	T5282	T5283	amod	substantial,rescue
R307	T918	T909	punct	", ",lagged
R3070	T5283	T5281	pobj	rescue,in
R3071	T5284	T5282	cc	and,substantial
R3072	T5285	T5286	advmod	long,lasting
R3073	T5286	T5282	conj	lasting,substantial
R3074	T5287	T5286	punct	-,lasting
R3075	T5288	T5283	prep	of,rescue
R3076	T5289	T5290	compound	photoreceptor,structure
R3077	T5290	T5288	pobj	structure,of
R3078	T5291	T5283	cc	and,rescue
R3079	T5292	T5293	amod	transient,rescue
R308	T919	T909	aux	has,lagged
R3080	T5293	T5283	conj	rescue,rescue
R3081	T5294	T5293	prep	of,rescue
R3082	T5295	T5296	compound	photoreceptor,physiology
R3083	T5296	T5294	pobj	physiology,of
R3084	T5297	T5273	punct	.,resulted
R3085	T5299	T5300	advmod	However,failed
R3086	T5301	T5300	punct	", ",failed
R3087	T5302	T5300	nsubj	expression,failed
R3088	T5303	T5304	advmod	shortly,before
R3089	T5304	T5302	prep	before,expression
R309	T920	T909	prep	behind,lagged
R3090	T5305	T5304	cc	or,before
R3091	T5306	T5304	conj	after,before
R3092	T5307	T5308	det	this,period
R3093	T5308	T5306	pobj	period,after
R3094	T5309	T5308	amod	critical,period
R3095	T5310	T5311	aux	to,rescue
R3096	T5311	T5300	xcomp	rescue,failed
R3097	T5312	T5300	punct	", ",failed
R3098	T5313	T5300	advcl	suggesting,failed
R3099	T5314	T5315	mark	that,is
R31	T149	T147	cc	or,blind
R310	T921	T922	poss	our,understanding
R3100	T5315	T5313	ccomp	is,suggesting
R3101	T5316	T5317	compound	rhodopsin,expression
R3102	T5317	T5315	nsubj	expression,is
R3103	T5318	T5317	prep	during,expression
R3104	T5319	T5320	det	a,window
R3105	T5320	T5318	pobj	window,during
R3106	T5321	T5320	amod	discrete,window
R3107	T5322	T5320	prep	of,window
R3108	T5323	T5322	pobj	time,of
R3109	T5324	T5320	prep	in,window
R311	T922	T920	pobj	understanding,behind
R3110	T5325	T5324	pobj	development,in
R3111	T5326	T5315	acomp	essential,is
R3112	T5327	T5326	prep	for,essential
R3113	T5328	T5329	amod	proper,morphogenesis
R3114	T5329	T5327	pobj	morphogenesis,for
R3115	T5330	T5329	amod	rhabdomere,morphogenesis
R3116	T5331	T5300	punct	.,failed
R3117	T5333	T5334	det	This,result
R3118	T5334	T5335	nsubj	result,is
R3119	T5336	T5335	acomp	consistent,is
R312	T923	T922	prep	of,understanding
R3120	T5337	T5336	prep	with,consistent
R3121	T5338	T5337	pobj	observations,with
R3122	T5339	T5338	prep	in,observations
R3123	T5340	T5341	det	the,rat
R3124	T5341	T5339	pobj	rat,in
R3125	T5342	T5343	prep	wherein,occurs
R3126	T5343	T5338	relcl	occurs,observations
R3127	T5344	T5345	compound	rhodopsin,onset
R3128	T5345	T5343	nsubj	onset,occurs
R3129	T5346	T5343	prep	with,occurs
R313	T924	T923	pobj	function,of
R3130	T5347	T5348	amod	strict,timing
R3131	T5348	T5346	pobj	timing,with
R3132	T5349	T5343	prep	in,occurs
R3133	T5350	T5351	det	the,history
R3134	T5351	T5349	pobj	history,in
R3135	T5352	T5351	amod	developmental,history
R3136	T5353	T5351	prep	of,history
R3137	T5354	T5355	amod	most,rods
R3138	T5355	T5353	pobj	rods,of
R3139	T5356	T5357	advmod	in,vivo
R314	T925	T909	punct	.,lagged
R3140	T5357	T5343	advmod	vivo,occurs
R3141	T5358	T5359	punct	[,44
R3142	T5359	T5338	parataxis	44,observations
R3143	T5360	T5359	punct	],44
R3144	T5361	T5335	punct	.,is
R3145	T5363	T5364	advmod	Thus,regulating
R3146	T5365	T5364	punct	", ",regulating
R3147	T5366	T5364	prep	through,regulating
R3148	T5367	T5368	poss	its,regulation
R3149	T5368	T5366	pobj	regulation,through
R315	T927	T928	advmod	Only,recently
R3150	T5369	T5368	prep	of,regulation
R3151	T5370	T5371	compound	rhodopsin,levels
R3152	T5371	T5369	pobj	levels,of
R3153	T5372	T5366	punct	", ",through
R3154	T5373	T5366	cc	or,through
R3155	T5374	T5375	advmod	perhaps,through
R3156	T5375	T5366	conj	through,through
R3157	T5376	T5375	pobj	control,through
R3158	T5377	T5376	prep	of,control
R3159	T5378	T5379	det	the,kinetics
R316	T928	T929	advmod	recently,identified
R3160	T5379	T5377	pobj	kinetics,of
R3161	T5380	T5379	prep	of,kinetics
R3162	T5381	T5382	det	the,regulation
R3163	T5382	T5380	pobj	regulation,of
R3164	T5383	T5382	amod	up,regulation
R3165	T5384	T5382	punct	-,regulation
R3166	T5385	T5382	prep	of,regulation
R3167	T5386	T5385	pobj	rhodopsin,of
R3168	T5387	T5382	acl	beginning,regulation
R3169	T5388	T5387	prep	at,beginning
R317	T930	T929	aux	have,identified
R3170	T5389	T5390	advmod	about,P6
R3171	T5390	T5388	pobj	P6,at
R3172	T5391	T5364	punct	", ",regulating
R3173	T5392	T5364	nsubj	Crx,regulating
R3174	T5393	T5364	aux	may,regulating
R3175	T5394	T5364	aux	be,regulating
R3176	T5395	T5396	amod	outer,segment
R3177	T5396	T5397	compound	segment,morphogenesis
R3178	T5397	T5364	dobj	morphogenesis,regulating
R3179	T5398	T5364	punct	.,regulating
R318	T931	T932	det	the,mechanisms
R3180	T5400	T5401	det	The,similarty
R3181	T5401	T5402	nsubj	similarty,extend
R3182	T5403	T5401	prep	of,similarty
R3183	T5404	T5405	det	the,cases
R3184	T5405	T5403	pobj	cases,of
R3185	T5406	T5405	nummod	two,cases
R3186	T5407	T5402	aux	may,extend
R3187	T5408	T5402	advmod	further,extend
R3188	T5409	T5402	punct	.,extend
R3189	T5411	T5412	prep	At,is
R319	T932	T929	nsubjpass	mechanisms,identified
R3190	T5413	T5411	amod	present,At
R3191	T5414	T5412	punct	", ",is
R3192	T5415	T5416	det	the,Crx
R3193	T5416	T5412	nsubj	Crx,is
R3194	T5417	T5416	amod	closest,Crx
R3195	T5418	T5416	amod	relative,Crx
R3196	T5419	T5416	prep	in,Crx
R3197	T5420	T5419	pobj	Drosophila,in
R3198	T5421	T5412	attr	Otd,is
R3199	T5422	T5421	punct	", ",Otd
R32	T150	T151	advmod	nearly,so
R320	T933	T932	amod	first,mechanisms
R3200	T5423	T5424	det	the,member
R3201	T5424	T5421	appos	member,Otd
R3202	T5425	T5424	amod	founding,member
R3203	T5426	T5424	prep	of,member
R3204	T5427	T5428	det	the,class
R3205	T5428	T5426	pobj	class,of
R3206	T5429	T5428	prep	of,class
R3207	T5430	T5431	compound	homeobox,genes
R3208	T5431	T5429	pobj	genes,of
R3209	T5432	T5433	prep	to,belongs
R321	T934	T932	amod	molecular,mechanisms
R3210	T5433	T5431	relcl	belongs,genes
R3211	T5434	T5432	pobj	which,to
R3212	T5435	T5433	nsubj	Crx,belongs
R3213	T5436	T5412	punct	.,is
R3214	T5438	T5439	advmod	Interestingly,disrupted
R3215	T5440	T5439	punct	", ",disrupted
R3216	T5441	T5439	prep	in,disrupted
R3217	T5442	T5443	nummod	one,allele
R3218	T5443	T5441	pobj	allele,in
R3219	T5444	T5443	amod	hypomorphic,allele
R322	T935	T932	acl	regulating,mechanisms
R3220	T5445	T5443	prep	of,allele
R3221	T5446	T5447	compound	Drosophila,otd
R3222	T5447	T5445	pobj	otd,of
R3223	T5448	T5443	punct	", ",allele
R3224	T5449	T5443	appos	otduvi,allele
R3225	T5450	T5439	punct	", ",disrupted
R3226	T5451	T5452	compound	photoreceptor,morphogenesis
R3227	T5452	T5439	nsubjpass	morphogenesis,disrupted
R3228	T5453	T5439	auxpass	is,disrupted
R3229	T5454	T5439	advmod	also,disrupted
R323	T936	T937	compound	photoreceptor,development
R3230	T5455	T5456	punct	[,45
R3231	T5456	T5439	parataxis	45,disrupted
R3232	T5457	T5456	punct	],45
R3233	T5458	T5439	punct	.,disrupted
R3234	T5460	T5461	nsubj	We,found
R3235	T5462	T5463	mark	that,are
R3236	T5463	T5461	ccomp	are,found
R3237	T5464	T5463	expl	there,are
R3238	T5465	T5466	amod	many,genes
R3239	T5466	T5463	attr	genes,are
R324	T937	T935	dobj	development,regulating
R3240	T5467	T5466	amod	other,genes
R3241	T5468	T5469	dep	that,are
R3242	T5469	T5466	relcl	are,genes
R3243	T5470	T5469	acomp	dependent,are
R3244	T5471	T5470	prep	upon,dependent
R3245	T5472	T5471	pobj	Crx,upon
R3246	T5473	T5461	punct	.,found
R3247	T5475	T5476	nsubj	Those,comprise
R3248	T5477	T5478	dep	that,expressed
R3249	T5478	T5475	relcl	expressed,Those
R325	T938	T929	auxpass	been,identified
R3250	T5479	T5478	auxpass	are,expressed
R3251	T5480	T5478	prep	at,expressed
R3252	T5481	T5482	det	a,level
R3253	T5482	T5480	pobj	level,at
R3254	T5483	T5482	amod	lower,level
R3255	T5484	T5478	prep	in,expressed
R3256	T5485	T5486	det	the,retina
R3257	T5486	T5484	pobj	retina,in
R3258	T5487	T5486	nmod	Crx,retina
R3259	T5488	T5487	punct	-,Crx
R326	T939	T940	punct	(,see
R3260	T5489	T5487	punct	/,Crx
R3261	T5490	T5487	punct	-,Crx
R3262	T5491	T5475	punct	", ",Those
R3263	T5492	T5493	amod	such,as
R3264	T5493	T5475	prep	as,Those
R3265	T5494	T5493	pobj	rhodopsin,as
R3266	T5495	T5494	cc	and,rhodopsin
R3267	T5496	T5494	conj	peripherin,rhodopsin
R3268	T5497	T5476	punct	", ",comprise
R3269	T5498	T5476	dobj	many,comprise
R327	T940	T929	parataxis	see,identified
R3270	T5499	T5500	dep	that,are
R3271	T5500	T5498	relcl	are,many
R3272	T5501	T5502	advmod	either,enriched
R3273	T5502	T5500	acomp	enriched,are
R3274	T5503	T5502	cc	or,enriched
R3275	T5504	T5502	conj	specific,enriched
R3276	T5505	T5504	prep	to,specific
R3277	T5506	T5505	pobj	photoreceptors,to
R3278	T5507	T5500	prep	in,are
R3279	T5508	T5509	poss	their,expression
R328	T941	T940	prep	for,see
R3280	T5509	T5507	pobj	expression,in
R3281	T5510	T5511	punct	[,35
R3282	T5511	T5476	parataxis	35,comprise
R3283	T5512	T5511	punct	],35
R3284	T5513	T5476	punct	.,comprise
R3285	T5515	T5516	nsubj	They,include
R3286	T5517	T5516	dobj	enzymes,include
R3287	T5518	T5519	dep	that,are
R3288	T5519	T5517	relcl	are,enzymes
R3289	T5520	T5519	acomp	important,are
R329	T942	T941	pobj	review,for
R3290	T5521	T5520	prep	in,important
R3291	T5522	T5523	compound	lipid,metabolism
R3292	T5523	T5521	pobj	metabolism,in
R3293	T5524	T5523	punct	", ",metabolism
R3294	T5525	T5526	compound	protein,folding
R3295	T5526	T5523	appos	folding,metabolism
R3296	T5527	T5526	cc	and,folding
R3297	T5528	T5526	conj	transport,folding
R3298	T5529	T5521	punct	", ",in
R3299	T5530	T5531	advmod	as,as
R33	T151	T147	conj	so,blind
R330	T943	T940	punct	", ",see
R3300	T5531	T5521	cc	as,in
R3301	T5532	T5531	advmod	well,as
R3302	T5533	T5521	conj	in,in
R3303	T5534	T5535	amod	other,processes
R3304	T5535	T5533	pobj	processes,in
R3305	T5536	T5537	dep	that,envision
R3306	T5537	T5535	relcl	envision,processes
R3307	T5538	T5537	nsubj	one,envision
R3308	T5539	T5537	aux	might,envision
R3309	T5540	T5541	aux	would,be
R331	T944	T940	punct	[,see
R3310	T5541	T5537	xcomp	be,envision
R3311	T5542	T5541	acomp	important,be
R3312	T5543	T5541	prep	in,be
R3313	T5544	T5543	pcomp	building,in
R3314	T5545	T5546	det	a,structure
R3315	T5546	T5544	dobj	structure,building
R3316	T5547	T5548	amod	such,as
R3317	T5548	T5546	prep	as,structure
R3318	T5549	T5550	det	the,segment
R3319	T5550	T5548	pobj	segment,as
R332	T945	T946	nummod	2,4
R3320	T5551	T5550	amod	outer,segment
R3321	T5552	T5516	punct	.,include
R3322	T5554	T5555	advmod	In,situ
R3323	T5555	T5556	amod	situ,hybridization
R3324	T5556	T5557	nsubj	hybridization,revealed
R3325	T5558	T5556	acl	using,hybridization
R3326	T5559	T5558	dobj	probes,using
R3327	T5560	T5559	prep	from,probes
R3328	T5561	T5562	det	this,collection
R3329	T5562	T5560	pobj	collection,from
R333	T946	T940	dobj	4,see
R3330	T5563	T5562	prep	of,collection
R3331	T5564	T5563	pobj	genes,of
R3332	T5565	T5557	aux	has,revealed
R3333	T5566	T5567	mark	that,have
R3334	T5567	T5557	ccomp	have,revealed
R3335	T5568	T5567	nsubj	some,have
R3336	T5569	T5568	prep	of,some
R3337	T5570	T5569	pobj	them,of
R3338	T5571	T5572	poss	their,RNA
R3339	T5572	T5573	nsubj	RNA,localized
R334	T947	T946	punct	",",4
R3340	T5573	T5567	ccomp	localized,have
R3341	T5574	T5573	prep	to,localized
R3342	T5575	T5576	det	the,segment
R3343	T5576	T5574	pobj	segment,to
R3344	T5577	T5576	amod	inner,segment
R3345	T5578	T5557	punct	", ",revealed
R3346	T5579	T5580	det	a,finding
R3347	T5580	T5557	npadvmod	finding,revealed
R3348	T5581	T5580	amod	typical,finding
R3349	T5582	T5581	prep	for,typical
R335	T948	T940	punct	],see
R3350	T5583	T5582	pobj	proteins,for
R3351	T5584	T5583	acl	targeted,proteins
R3352	T5585	T5584	prep	to,targeted
R3353	T5586	T5587	det	the,segment
R3354	T5587	T5585	pobj	segment,to
R3355	T5588	T5587	amod	outer,segment
R3356	T5589	T5557	punct	.,revealed
R3357	T5591	T5592	amod	Future,analyses
R3358	T5592	T5593	nsubj	analyses,reveal
R3359	T5594	T5592	prep	of,analyses
R336	T949	T940	punct	),see
R3360	T5595	T5596	det	the,function
R3361	T5596	T5594	pobj	function,of
R3362	T5597	T5596	prep	of,function
R3363	T5598	T5599	det	these,genes
R3364	T5599	T5597	pobj	genes,of
R3365	T5600	T5593	aux	might,reveal
R3366	T5601	T5602	poss	their,role
R3367	T5602	T5593	dobj	role,reveal
R3368	T5603	T5602	prep	in,role
R3369	T5604	T5605	amod	outer,segment
R337	T950	T929	punct	.,identified
R3370	T5605	T5606	compound	segment,biogenesis
R3371	T5606	T5603	pobj	biogenesis,in
R3372	T5607	T5593	punct	.,reveal
R3373	T5609	T5610	advmod	Finally,found
R3374	T5611	T5610	punct	", ",found
R3375	T5612	T5610	nsubjpass	polarization,found
R3376	T5613	T5612	prep	of,polarization
R3377	T5614	T5613	pobj	photoreceptors,of
R3378	T5615	T5610	auxpass	was,found
R3379	T5616	T5617	aux	to,be
R338	T952	T953	nsubj	Crx,is
R3380	T5617	T5610	xcomp	be,found
R3381	T5618	T5619	advmod	largely,intact
R3382	T5619	T5617	acomp	intact,be
R3383	T5620	T5617	punct	", ",be
R3384	T5621	T5622	mark	as,was
R3385	T5622	T5617	advcl	was,be
R3386	T5623	T5622	nsubj	ciliogenesis,was
R3387	T5624	T5610	punct	.,found
R3388	T5626	T5627	det	Another,gene
R3389	T5627	T5629	nsubjpass	gene,implicated
R339	T954	T952	punct	(,Crx
R3390	T5628	T5627	compound	LCA,gene
R3391	T5630	T5627	punct	", ",gene
R3392	T5631	T5627	appos	CRB1,gene
R3393	T5632	T5627	punct	", ",gene
R3394	T5633	T5627	cc	and,gene
R3395	T5634	T5635	det	a,gene
R3396	T5635	T5627	conj	gene,gene
R3397	T5636	T5635	amod	related,gene
R3398	T5637	T5635	appos	CRB3,gene
R3399	T5638	T5629	punct	", ",implicated
R34	T152	T136	punct	", ",are
R340	T955	T956	compound	cone,rod
R3400	T5639	T5629	aux	have,implicated
R3401	T5640	T5629	auxpass	been,implicated
R3402	T5641	T5629	prep	in,implicated
R3403	T5642	T5641	pobj	ciliogenesis,in
R3404	T5643	T5629	prep	in,implicated
R3405	T5644	T5645	advmod	in,vitro
R3406	T5645	T5646	amod	vitro,models
R3407	T5646	T5643	pobj	models,in
R3408	T5647	T5648	punct	[,46
R3409	T5648	T5629	parataxis	46,implicated
R341	T956	T958	compound	rod,homeobox
R3410	T5649	T5648	punct	],46
R3411	T5650	T5629	punct	.,implicated
R3412	T5652	T5653	det	The,homologue
R3413	T5653	T5655	nsubjpass	homologue,implicated
R3414	T5654	T5653	compound	Drosophila,homologue
R3415	T5656	T5653	prep	of,homologue
R3416	T5657	T5656	pobj	CRB1,of
R3417	T5658	T5653	punct	", ",homologue
R3418	T5659	T5653	appos	Crumbs,homologue
R3419	T5660	T5655	punct	", ",implicated
R342	T957	T956	punct	-,rod
R3420	T5661	T5655	aux	has,implicated
R3421	T5662	T5655	auxpass	been,implicated
R3422	T5663	T5655	prep	in,implicated
R3423	T5664	T5665	compound	photoreceptor,morphogenesis
R3424	T5665	T5663	pobj	morphogenesis,in
R3425	T5666	T5667	punct	[,47
R3426	T5667	T5655	parataxis	47,implicated
R3427	T5668	T5667	punct	],47
R3428	T5669	T5655	punct	.,implicated
R3429	T5671	T5672	advmod	However,develops
R343	T958	T952	appos	homeobox,Crx
R3430	T5673	T5672	punct	", ",develops
R3431	T5674	T5675	det	the,mutant
R3432	T5675	T5672	nsubj	mutant,develops
R3433	T5676	T5677	advmod	spontaneously,occurring
R3434	T5677	T5675	amod	occurring,mutant
R3435	T5678	T5675	compound	mouse,mutant
R3436	T5679	T5675	prep	in,mutant
R3437	T5680	T5679	pobj	CRB1,in
R3438	T5681	T5675	punct	", ",mutant
R3439	T5682	T5683	det	the,mouse
R344	T959	T953	punct	),is
R3440	T5683	T5675	appos	mouse,mutant
R3441	T5684	T5683	compound	Rd8,mouse
R3442	T5685	T5672	punct	", ",develops
R3443	T5686	T5687	amod	shortened,segments
R3444	T5687	T5672	dobj	segments,develops
R3445	T5688	T5687	amod	outer,segments
R3446	T5689	T5690	dep	that,degenerate
R3447	T5690	T5687	relcl	degenerate,segments
R3448	T5691	T5690	advmod	subsequently,degenerate
R3449	T5692	T5693	punct	[,48
R345	T960	T961	det	an,gene
R3450	T5693	T5672	parataxis	48,develops
R3451	T5694	T5693	punct	],48
R3452	T5695	T5672	punct	", ",develops
R3453	T5696	T5672	advcl	suggesting,develops
R3454	T5697	T5698	mark	that,are
R3455	T5698	T5696	ccomp	are,suggesting
R3456	T5699	T5700	compound	photoreceptor,polarization
R3457	T5700	T5698	nsubj	polarization,are
R3458	T5701	T5700	cc	and,polarization
R3459	T5702	T5700	conj	synaptogenesis,polarization
R346	T961	T953	attr	gene,is
R3460	T5703	T5698	acomp	intact,are
R3461	T5704	T5698	prep	in,are
R3462	T5705	T5706	det	this,mutant
R3463	T5706	T5704	pobj	mutant,in
R3464	T5707	T5672	punct	.,develops
R3465	T5709	T5710	mark	While,linked
R3466	T5710	T5717	advcl	linked,is
R3467	T5711	T5710	nsubjpass	CRB1,linked
R3468	T5712	T5711	cc	and,CRB1
R3469	T5713	T5711	conj	Crx,CRB1
R347	T962	T963	compound	otx,family
R3470	T5714	T5710	aux	have,linked
R3471	T5715	T5710	auxpass	been,linked
R3472	T5716	T5710	advmod	both,linked
R3473	T5718	T5710	prep	to,linked
R3474	T5719	T5718	pobj	LCA,to
R3475	T5720	T5717	punct	", ",is
R3476	T5721	T5722	amod	further,work
R3477	T5722	T5717	nsubj	work,is
R3478	T5723	T5717	acomp	necessary,is
R3479	T5724	T5725	aux	to,determine
R348	T963	T965	compound	family,homeobox
R3480	T5725	T5723	xcomp	determine,necessary
R3481	T5726	T5727	mark	if,linked
R3482	T5727	T5725	ccomp	linked,determine
R3483	T5728	T5729	poss	their,function
R3484	T5729	T5727	nsubjpass	function,linked
R3485	T5730	T5727	auxpass	is,linked
R3486	T5731	T5727	prep	in,linked
R3487	T5732	T5733	amod	retinal,development
R3488	T5733	T5731	pobj	development,in
R3489	T5734	T5717	punct	.,is
R349	T964	T963	punct	-,family
R3492	T6165	T6166	nsubjpass	Synaptogenesis,perturbed
R3493	T6167	T6166	auxpass	is,perturbed
R3494	T6168	T6166	prep	in,perturbed
R3495	T6169	T6170	nmod	Crx,photoreceptors
R3496	T6170	T6168	pobj	photoreceptors,in
R3497	T6171	T6169	punct	-,Crx
R3498	T6172	T6169	punct	/,Crx
R3499	T6173	T6169	punct	-,Crx
R35	T153	T136	prep	from,are
R350	T965	T961	compound	homeobox,gene
R3500	T6175	T6176	det	The,mouse
R3501	T6176	T6181	nsubj	mouse,demonstrates
R3502	T6177	T6176	nmod	Crx,mouse
R3503	T6178	T6177	punct	-,Crx
R3504	T6179	T6177	punct	/,Crx
R3505	T6180	T6177	punct	-,Crx
R3506	T6182	T6183	det	the,abnormality
R3507	T6183	T6181	dobj	abnormality,demonstrates
R3508	T6184	T6185	advmod	most,severe
R3509	T6185	T6183	amod	severe,abnormality
R351	T966	T961	acl	expressed,gene
R3510	T6186	T6183	prep	of,abnormality
R3511	T6187	T6188	compound	photoreceptor,synapses
R3512	T6188	T6186	pobj	synapses,of
R3513	T6189	T6183	acl	reported,abnormality
R3514	T6190	T6189	prep	to,reported
R3515	T6191	T6190	pobj	date,to
R3516	T6192	T6181	punct	.,demonstrates
R3517	T6194	T6195	det	The,mouse
R3518	T6195	T6200	nsubj	mouse,develops
R3519	T6196	T6195	nmod	peripherin,mouse
R352	T967	T966	advmod	predominantly,expressed
R3520	T6197	T6196	punct	-,peripherin
R3521	T6198	T6196	punct	/,peripherin
R3522	T6199	T6196	punct	-,peripherin
R3523	T6201	T6202	det	a,complement
R3524	T6202	T6200	dobj	complement,develops
R3525	T6203	T6202	amod	normal,complement
R3526	T6204	T6202	prep	of,complement
R3527	T6205	T6206	compound	photoreceptor,terminals
R3528	T6206	T6204	pobj	terminals,of
R3529	T6207	T6208	dep	which,degenerate
R353	T968	T966	prep	in,expressed
R3530	T6208	T6202	relcl	degenerate,complement
R3531	T6209	T6208	advmod	then,degenerate
R3532	T6210	T6211	mark	as,lost
R3533	T6211	T6208	advcl	lost,degenerate
R3534	T6212	T6213	det	the,photoreceptors
R3535	T6213	T6211	nsubjpass	photoreceptors,lost
R3536	T6214	T6211	auxpass	are,lost
R3537	T6215	T6216	punct	[,30
R3538	T6216	T6200	parataxis	30,develops
R3539	T6217	T6216	punct	],30
R354	T969	T968	pobj	photoreceptors,in
R3540	T6218	T6200	punct	.,develops
R3541	T6220	T6221	advmod	Also,reported
R3542	T6222	T6221	punct	", ",reported
R3543	T6223	T6221	advmod	similarly,reported
R3544	T6224	T6221	prep	in,reported
R3545	T6225	T6224	pobj	rhodopsin,in
R3546	T6226	T6225	punct	(,rhodopsin
R3547	T6227	T6225	appos	Rho,rhodopsin
R3548	T6228	T6225	punct	),rhodopsin
R3549	T6229	T6225	cc	and,rhodopsin
R355	T970	T966	punct	", ",expressed
R3550	T6230	T6231	amod	cyclic,channel
R3551	T6231	T6235	nmod	channel,alpha
R3552	T6232	T6233	npadvmod	nucleotide,gated
R3553	T6233	T6231	amod	gated,channel
R3554	T6234	T6233	punct	-,gated
R3555	T6235	T6237	nmod	alpha,mice
R3556	T6236	T6235	punct	", ",alpha
R3557	T6237	T6225	conj	mice,rhodopsin
R3558	T6238	T6235	punct	-,alpha
R3559	T6239	T6235	nummod	3,alpha
R356	T971	T966	prep	from,expressed
R3560	T6240	T6235	punct	(,alpha
R3561	T6241	T6235	appos	CNGA3,alpha
R3562	T6242	T6237	punct	),mice
R3563	T6243	T6244	amod	double,knockout
R3564	T6244	T6237	compound	knockout,mice
R3565	T6245	T6237	punct	(,mice
R3566	T6246	T6237	appos	Rho,mice
R3567	T6247	T6246	punct	-,Rho
R3568	T6248	T6246	punct	/,Rho
R3569	T6249	T6246	punct	-,Rho
R357	T972	T971	pcomp	early,from
R3570	T6250	T6246	punct	", ",Rho
R3571	T6251	T6246	appos	CNGA3,Rho
R3572	T6252	T6251	punct	-,CNGA3
R3573	T6253	T6251	punct	/,CNGA3
R3574	T6254	T6251	punct	-,CNGA3
R3575	T6255	T6221	punct	),reported
R3576	T6256	T6221	punct	", ",reported
R3577	T6257	T6221	nsubjpass	synapses,reported
R3578	T6258	T6221	auxpass	are,reported
R3579	T6259	T6260	aux	to,form
R358	T973	T972	prep	in,early
R3580	T6260	T6221	xcomp	form,reported
R3581	T6261	T6260	advmod	normally,form
R3582	T6262	T6263	punct	[,49
R3583	T6263	T6221	parataxis	49,reported
R3584	T6264	T6263	punct	],49
R3585	T6265	T6221	punct	.,reported
R3586	T6267	T6268	det	These,observations
R3587	T6268	T6269	nsubj	observations,demonstrate
R3588	T6270	T6271	mark	that,occur
R3589	T6271	T6269	ccomp	occur,demonstrate
R359	T974	T975	poss	their,development
R3590	T6272	T6273	compound	photoreceptor,synaptogenesis
R3591	T6273	T6271	nsubj	synaptogenesis,occur
R3592	T6274	T6271	aux	can,occur
R3593	T6275	T6271	prep	in,occur
R3594	T6276	T6277	det	the,absence
R3595	T6277	T6275	pobj	absence,in
R3596	T6278	T6277	prep	of,absence
R3597	T6279	T6280	amod	outer,segment
R3598	T6280	T6281	compound	segment,formation
R3599	T6281	T6278	pobj	formation,of
R36	T154	T153	pobj	birth,from
R360	T975	T973	pobj	development,in
R3600	T6282	T6269	punct	.,demonstrate
R3601	T6284	T6285	prep	In,is
R3602	T6286	T6284	pcomp	keeping,In
R3603	T6287	T6286	prep	with,keeping
R3604	T6288	T6289	det	this,observation
R3605	T6289	T6287	pobj	observation,with
R3606	T6290	T6291	det	the,fact
R3607	T6291	T6285	nsubj	fact,is
R3608	T6292	T6293	mark	that,is
R3609	T6293	T6291	acl	is,fact
R361	T976	T971	prep	through,from
R3610	T6294	T6295	det	some,activity
R3611	T6295	T6293	nsubj	activity,is
R3612	T6296	T6295	compound	electroretinogram,activity
R3613	T6297	T6293	acomp	present,is
R3614	T6298	T6293	prep	in,is
R3615	T6299	T6300	nmod	peripherin,mice
R3616	T6300	T6298	pobj	mice,in
R3617	T6301	T6299	punct	-,peripherin
R3618	T6302	T6299	punct	/,peripherin
R3619	T6303	T6299	punct	-,peripherin
R362	T977	T976	prep	to,through
R3620	T6304	T6293	punct	", ",is
R3621	T6305	T6293	advcl	suggesting,is
R3622	T6306	T6307	mark	that,is
R3623	T6307	T6305	ccomp	is,suggesting
R3624	T6308	T6309	amod	minimal,phototransduction
R3625	T6309	T6307	nsubj	phototransduction,is
R3626	T6310	T6307	acomp	present,is
R3627	T6311	T6307	prep	in,is
R3628	T6312	T6313	det	these,mice
R3629	T6313	T6311	pobj	mice,in
R363	T978	T979	det	the,ages
R3630	T6314	T6307	punct	", ",is
R3631	T6315	T6307	advmod	enough,is
R3632	T6316	T6317	aux	to,drive
R3633	T6317	T6315	xcomp	drive,enough
R3634	T6318	T6317	dobj	activity,drive
R3635	T6319	T6317	prep	at,drive
R3636	T6320	T6321	det	the,synapse
R3637	T6321	T6319	pobj	synapse,at
R3638	T6322	T6321	compound	photoreceptor,synapse
R3639	T6323	T6285	punct	.,is
R364	T979	T977	pobj	ages,to
R3640	T6325	T6326	advmod	In,vitro
R3641	T6326	T6327	amod	vitro,studies
R3642	T6327	T6328	nsubj	studies,indicated
R3643	T6329	T6330	prep	wherein,formed
R3644	T6330	T6327	relcl	formed,studies
R3645	T6331	T6332	compound	synapse,elements
R3646	T6332	T6330	nsubjpass	elements,formed
R3647	T6333	T6330	auxpass	are,formed
R3648	T6334	T6330	prep	in,formed
R3649	T6335	T6336	det	the,absence
R365	T980	T979	amod	adult,ages
R3650	T6336	T6334	pobj	absence,in
R3651	T6337	T6336	prep	of,absence
R3652	T6338	T6339	amod	proper,development
R3653	T6339	T6337	pobj	development,of
R3654	T6340	T6341	amod	outer,segment
R3655	T6341	T6339	compound	segment,development
R3656	T6342	T6336	cc	and,absence
R3657	T6343	T6336	punct	", ",absence
R3658	T6344	T6345	advmod	therefore,absence
R3659	T6345	T6336	conj	absence,absence
R366	T981	T982	punct	[,5
R3660	T6346	T6345	punct	", ",absence
R3661	T6347	T6345	amod	possible,absence
R3662	T6348	T6345	prep	of,absence
R3663	T6349	T6350	npadvmod	light,dependent
R3664	T6350	T6352	amod	dependent,activity
R3665	T6351	T6350	punct	-,dependent
R3666	T6352	T6348	pobj	activity,of
R3667	T6353	T6352	compound	photoreceptor,activity
R3668	T6354	T6328	punct	", ",indicated
R3669	T6355	T6328	aux	have,indicated
R367	T982	T966	parataxis	5,expressed
R3670	T6356	T6357	det	the,independence
R3671	T6357	T6328	dobj	independence,indicated
R3672	T6358	T6357	prep	of,independence
R3673	T6359	T6358	pobj	phototransduction,of
R3674	T6360	T6359	cc	and,phototransduction
R3675	T6361	T6362	compound	synapse,formation
R3676	T6362	T6359	conj	formation,phototransduction
R3677	T6363	T6328	punct	", ",indicated
R3678	T6364	T6365	advmod	at,least
R3679	T6365	T6366	advmod	least,for
R368	T983	T984	punct	-,7
R3680	T6366	T6328	prep	for,indicated
R3681	T6367	T6368	det	the,stages
R3682	T6368	T6366	pobj	stages,for
R3683	T6369	T6368	amod	initial,stages
R3684	T6370	T6371	punct	[,51
R3685	T6371	T6328	parataxis	51,indicated
R3686	T6372	T6371	nummod	50,51
R3687	T6373	T6371	punct	",",51
R3688	T6374	T6371	punct	],51
R3689	T6375	T6328	punct	.,indicated
R369	T984	T982	prep	7,5
R3690	T6377	T6378	det	These,data
R3691	T6378	T6379	nsubj	data,suggest
R3692	T6380	T6379	advmod	then,suggest
R3693	T6381	T6382	mark	that,is
R3694	T6382	T6379	ccomp	is,suggest
R3695	T6383	T6384	det	the,fact
R3696	T6384	T6382	nsubj	fact,is
R3697	T6385	T6386	mark	that,have
R3698	T6386	T6384	acl	have,fact
R3699	T6387	T6388	det	the,photoreceptors
R37	T155	T136	punct	.,are
R370	T985	T982	punct	],5
R3700	T6388	T6386	nsubj	photoreceptors,have
R3701	T6389	T6388	nmod	Crx,photoreceptors
R3702	T6390	T6389	punct	-,Crx
R3703	T6391	T6389	punct	/,Crx
R3704	T6392	T6389	punct	-,Crx
R3705	T6393	T6386	aux	do,have
R3706	T6394	T6386	neg	not,have
R3707	T6395	T6396	amod	proper,endings
R3708	T6396	T6386	dobj	endings,have
R3709	T6397	T6396	amod	synaptic,endings
R371	T986	T953	punct	.,is
R3710	T6398	T6382	neg	not,is
R3711	T6399	T6382	prep	due,is
R3712	T6400	T6399	pcomp	to,due
R3713	T6401	T6402	det	a,lack
R3714	T6402	T6399	pobj	lack,due
R3715	T6403	T6402	prep	of,lack
R3716	T6404	T6405	amod	outer,segment
R3717	T6405	T6406	compound	segment,formation
R3718	T6406	T6403	pobj	formation,of
R3719	T6407	T6379	punct	.,suggest
R372	T988	T989	compound	Crx,expression
R3720	T6409	T6410	det	A,explanation
R3721	T6410	T6413	nsubj	explanation,is
R3722	T6411	T6412	advmod	more,likely
R3723	T6412	T6410	amod	likely,explanation
R3724	T6414	T6415	mark	that,plays
R3725	T6415	T6413	ccomp	plays,is
R3726	T6416	T6415	nsubj	Crx,plays
R3727	T6417	T6418	det	a,role
R3728	T6418	T6415	dobj	role,plays
R3729	T6419	T6415	prep	in,plays
R373	T989	T991	nsubj	expression,is
R3730	T6420	T6421	compound	photoreceptor,synapse
R3731	T6421	T6422	compound	synapse,formation
R3732	T6422	T6419	pobj	formation,in
R3733	T6423	T6415	punct	", ",plays
R3734	T6424	T6425	advmod	perhaps,by
R3735	T6425	T6415	prep	by,plays
R3736	T6426	T6425	pcomp	regulating,by
R3737	T6427	T6426	advmod	directly,regulating
R3738	T6428	T6427	punct	", ",directly
R3739	T6429	T6427	cc	or,directly
R374	T990	T989	compound	gene,expression
R3740	T6430	T6427	conj	indirectly,directly
R3741	T6431	T6426	punct	", ",regulating
R3742	T6432	T6433	amod	important,genes
R3743	T6433	T6426	dobj	genes,regulating
R3744	T6434	T6433	prep	in,genes
R3745	T6435	T6436	det	this,process
R3746	T6436	T6434	pobj	process,in
R3747	T6437	T6413	punct	.,is
R3748	T6439	T6440	advcl	Using,examined
R3749	T6441	T6439	dobj	immunohistochemistry,Using
R375	T992	T993	advmod	critically,dependent
R3750	T6442	T6440	punct	", ",examined
R3751	T6443	T6440	nsubj	we,examined
R3752	T6444	T6445	det	the,expression
R3753	T6445	T6440	dobj	expression,examined
R3754	T6446	T6440	prep	of,examined
R3755	T6447	T6448	amod	common,proteins
R3756	T6448	T6446	pobj	proteins,of
R3757	T6449	T6448	amod	pre-synaptic,proteins
R3758	T6450	T6448	amod	terminal,proteins
R3759	T6451	T6448	punct	", ",proteins
R376	T993	T991	acomp	dependent,is
R3760	T6452	T6448	prep	including,proteins
R3761	T6453	T6452	pobj	KIF3a,including
R3762	T6454	T6453	punct	", ",KIF3a
R3763	T6455	T6453	conj	SV2,KIF3a
R3764	T6456	T6455	punct	", ",SV2
R3765	T6457	T6455	cc	and,SV2
R3766	T6458	T6455	conj	synaptophysin,SV2
R3767	T6459	T6440	punct	", ",examined
R3768	T6460	T6440	cc	and,examined
R3769	T6461	T6440	conj	were,examined
R377	T994	T993	prep	upon,dependent
R3770	T6462	T6461	acomp	unable,were
R3771	T6463	T6464	aux	to,observe
R3772	T6464	T6462	xcomp	observe,unable
R3773	T6465	T6466	amod	qualitative,differences
R3774	T6466	T6464	dobj	differences,observe
R3775	T6467	T6466	prep	between,differences
R3776	T6468	T6469	nmod	Crx,tissue
R3777	T6469	T6467	pobj	tissue,between
R3778	T6470	T6468	punct	-,Crx
R3779	T6471	T6468	punct	/,Crx
R378	T995	T994	pobj	Otx2,upon
R3780	T6472	T6468	punct	-,Crx
R3781	T6473	T6468	cc	and,Crx
R3782	T6474	T6468	conj	control,Crx
R3783	T6475	T6464	prep	at,observe
R3784	T6476	T6475	pobj	P14,at
R3785	T6477	T6478	punct	(,shown
R3786	T6478	T6464	parataxis	shown,observe
R3787	T6479	T6478	nsubj	data,shown
R3788	T6480	T6478	neg	not,shown
R3789	T6481	T6478	punct	),shown
R379	T996	T995	punct	", ",Otx2
R3790	T6482	T6440	punct	.,examined
R3791	T6484	T6485	nsubj	Examination,showed
R3792	T6486	T6484	prep	of,Examination
R3793	T6487	T6488	poss	their,levels
R3794	T6488	T6486	pobj	levels,of
R3795	T6489	T6488	compound	RNA,levels
R3796	T6490	T6484	prep	by,Examination
R3797	T6491	T6490	pobj	SAGE,by
R3798	T6492	T6493	det	no,difference
R3799	T6493	T6485	dobj	difference,showed
R38	T157	T158	det	This,onset
R380	T997	T998	det	another,member
R3800	T6494	T6493	amod	significant,difference
R3801	T6495	T6485	prep	for,showed
R3802	T6496	T6497	det	all,genes
R3803	T6497	T6495	pobj	genes,for
R3804	T6498	T6497	nummod	3,genes
R3805	T6499	T6485	punct	", ",showed
R3806	T6500	T6501	mark	though,recovered
R3807	T6501	T6485	advcl	recovered,showed
R3808	T6502	T6503	advmod	very,few
R3809	T6503	T6504	amod	few,tags
R381	T998	T995	appos	member,Otx2
R3810	T6504	T6501	nsubjpass	tags,recovered
R3811	T6505	T6501	auxpass	were,recovered
R3812	T6506	T6501	prep	from,recovered
R3813	T6507	T6508	det	these,genes
R3814	T6508	T6506	pobj	genes,from
R3815	T6509	T6501	cc	and,recovered
R3816	T6510	T6511	advmod	thus,be
R3817	T6511	T6501	conj	be,recovered
R3818	T6512	T6513	det	the,analysis
R3819	T6513	T6511	nsubj	analysis,be
R382	T999	T998	prep	of,member
R3820	T6514	T6513	prep	of,analysis
R3821	T6515	T6516	compound	RNA,levels
R3822	T6516	T6514	pobj	levels,of
R3823	T6517	T6511	aux	may,be
R3824	T6518	T6511	neg	not,be
R3825	T6519	T6511	acomp	significant,be
R3826	T6520	T6521	punct	[,35
R3827	T6521	T6511	parataxis	35,be
R3828	T6522	T6521	punct	],35
R3829	T6523	T6485	punct	.,showed
R383	T1000	T1001	det	the,family
R3830	T6525	T6526	advmod	However,are
R3831	T6527	T6526	punct	", ",are
R3832	T6528	T6529	mark	since,altered
R3833	T6529	T6526	advcl	altered,are
R3834	T6530	T6531	amod	other,genes
R3835	T6531	T6529	nsubjpass	genes,altered
R3836	T6532	T6531	acl	expressed,genes
R3837	T6533	T6532	prep	in,expressed
R3838	T6534	T6533	pobj	photoreceptors,in
R3839	T6535	T6529	auxpass	were,altered
R384	T1001	T999	pobj	family,of
R3840	T6536	T6529	advmod	significantly,altered
R3841	T6537	T6529	prep	in,altered
R3842	T6538	T6539	poss	their,level
R3843	T6539	T6537	pobj	level,in
R3844	T6540	T6539	compound	expression,level
R3845	T6541	T6529	prep	in,altered
R3846	T6542	T6543	det	the,mouse
R3847	T6543	T6541	pobj	mouse,in
R3848	T6544	T6543	nmod	Crx,mouse
R3849	T6545	T6544	punct	-,Crx
R385	T1002	T1001	amod	same,family
R3850	T6546	T6544	punct	/,Crx
R3851	T6547	T6544	punct	-,Crx
R3852	T6548	T6526	punct	", ",are
R3853	T6549	T6526	expl	there,are
R3854	T6550	T6551	amod	many,candidates
R3855	T6551	T6526	attr	candidates,are
R3856	T6552	T6553	dep	that,be
R3857	T6553	T6551	relcl	be,candidates
R3858	T6554	T6553	aux	could,be
R3859	T6555	T6553	acomp	important,be
R386	T1003	T1001	compound	homeobox,family
R3860	T6556	T6555	prep	for,important
R3861	T6557	T6558	compound	photoreceptor,morphogenesis
R3862	T6558	T6556	pobj	morphogenesis,for
R3863	T6559	T6526	punct	.,are
R3864	T6561	T6562	nsubjpass	Tags,found
R3865	T6563	T6561	prep	from,Tags
R3866	T6564	T6565	nummod	three,genes
R3867	T6565	T6563	pobj	genes,from
R3868	T6566	T6565	prep	from,genes
R3869	T6567	T6566	pobj	proteins,from
R387	T1004	T1005	dep	which,expressed
R3870	T6568	T6567	acl	expressed,proteins
R3871	T6569	T6568	prep	in,expressed
R3872	T6570	T6571	compound	photoreceptor,terminals
R3873	T6571	T6569	pobj	terminals,in
R3874	T6572	T6562	auxpass	were,found
R3875	T6573	T6574	aux	to,decreased
R3876	T6574	T6562	xcomp	decreased,found
R3877	T6575	T6574	auxpass	be,decreased
R3878	T6576	T6574	prep	in,decreased
R3879	T6577	T6578	det	a,fashion
R388	T1005	T998	relcl	expressed,member
R3880	T6578	T6576	pobj	fashion,in
R3881	T6579	T6580	advmod	statistically,significant
R3882	T6580	T6578	amod	significant,fashion
R3883	T6581	T6562	punct	", ",found
R3884	T6582	T6583	advmod	namely,substrate
R3885	T6583	T6562	dobj	substrate,found
R3886	T6584	T6583	det	the,substrate
R3887	T6585	T6586	npadvmod	HGF,regulated
R3888	T6586	T6583	amod	regulated,substrate
R3889	T6587	T6586	punct	-,regulated
R389	T1006	T1005	auxpass	is,expressed
R3890	T6588	T6589	compound	tyrosine,kinase
R3891	T6589	T6583	compound	kinase,substrate
R3892	T6590	T6583	punct	", ",substrate
R3893	T6591	T6592	det	the,protein
R3894	T6592	T6583	conj	protein,substrate
R3895	T6593	T6592	compound	CRIPT,protein
R3896	T6594	T6592	punct	", ",protein
R3897	T6595	T6592	cc	and,protein
R3898	T6596	T6592	conj	synaptotagmin,protein
R3899	T6597	T6596	nummod	1,synaptotagmin
R39	T158	T160	nsubj	onset,suggests
R390	T1007	T1005	prep	in,expressed
R3900	T6598	T6599	punct	(,Blackshaw
R3901	T6599	T6562	meta	Blackshaw,found
R3902	T6600	T6599	cc	and,Blackshaw
R3903	T6601	T6599	conj	Cepko,Blackshaw
R3904	T6602	T6601	punct	", ",Cepko
R3905	T6603	T6604	amod	unpublished,data
R3906	T6604	T6601	conj	data,Cepko
R3907	T6605	T6604	punct	),data
R3908	T6606	T6562	punct	.,found
R3909	T6608	T6609	det	An,example
R391	T1008	T1009	amod	early,cells
R3910	T6609	T6610	nsubj	example,is
R3911	T6611	T6609	prep	of,example
R3912	T6612	T6613	det	a,gene
R3913	T6613	T6611	pobj	gene,of
R3914	T6614	T6615	dep	that,increased
R3915	T6615	T6613	relcl	increased,gene
R3916	T6616	T6615	auxpass	was,increased
R3917	T6617	T6615	prep	in,increased
R3918	T6618	T6619	det	the,retina
R3919	T6619	T6617	pobj	retina,in
R392	T1009	T1007	pobj	cells,in
R3920	T6620	T6619	nmod	Crx,retina
R3921	T6621	T6620	punct	-,Crx
R3922	T6622	T6620	punct	/,Crx
R3923	T6623	T6620	punct	-,Crx
R3924	T6624	T6610	attr	HRG4,is
R3925	T6625	T6624	punct	(,HRG4
R3926	T6626	T6627	det	a,homologue
R3927	T6627	T6624	appos	homologue,HRG4
R3928	T6628	T6627	prep	of,homologue
R3929	T6629	T6630	det	the,gene
R393	T1010	T1009	compound	photoreceptor,cells
R3930	T6630	T6628	pobj	gene,of
R3931	T6631	T6632	compound	C.,elegans
R3932	T6632	T6630	compound	elegans,gene
R3933	T6633	T6630	compound	Unc119,gene
R3934	T6634	T6624	punct	),HRG4
R3935	T6635	T6636	punct	(,Blackshaw
R3936	T6636	T6624	meta	Blackshaw,HRG4
R3937	T6637	T6636	cc	and,Blackshaw
R3938	T6638	T6636	conj	Cepko,Blackshaw
R3939	T6639	T6638	punct	", ",Cepko
R394	T1011	T1012	punct	[,8
R3940	T6640	T6641	amod	unpublished,data
R3941	T6641	T6638	conj	data,Cepko
R3942	T6642	T6641	punct	),data
R3943	T6643	T6644	dep	which,encodes
R3944	T6644	T6624	relcl	encodes,HRG4
R3945	T6645	T6646	det	a,component
R3946	T6646	T6644	dobj	component,encodes
R3947	T6647	T6646	prep	of,component
R3948	T6648	T6649	det	the,synapse
R3949	T6649	T6647	pobj	synapse,of
R395	T1012	T991	parataxis	8,is
R3950	T6650	T6649	compound	ribbon,synapse
R3951	T6651	T6652	punct	[,33
R3952	T6652	T6610	parataxis	33,is
R3953	T6653	T6652	punct	],33
R3954	T6654	T6610	punct	.,is
R3955	T6656	T6657	det	The,fact
R3956	T6657	T6658	nsubj	fact,indicate
R3957	T6659	T6660	mark	that,upregulated
R3958	T6660	T6657	acl	upregulated,fact
R3959	T6661	T6660	nsubjpass	it,upregulated
R396	T1013	T1012	punct	],8
R3960	T6662	T6660	auxpass	is,upregulated
R3961	T6663	T6658	aux	might,indicate
R3962	T6664	T6665	det	a,response
R3963	T6665	T6658	dobj	response,indicate
R3964	T6666	T6665	prep	to,response
R3965	T6667	T6668	det	the,lack
R3966	T6668	T6666	pobj	lack,to
R3967	T6669	T6668	prep	of,lack
R3968	T6670	T6671	amod	proper,structures
R3969	T6671	T6669	pobj	structures,of
R397	T1014	T991	punct	.,is
R3970	T6672	T6671	amod	terminal,structures
R3971	T6673	T6658	punct	.,indicate
R3972	T6675	T6676	amod	Several,genes
R3973	T6676	T6678	nsubj	genes,increased
R3974	T6677	T6676	amod	other,genes
R3975	T6679	T6676	acl	encoding,genes
R3976	T6680	T6681	amod	putative,elements
R3977	T6681	T6679	dobj	elements,encoding
R3978	T6682	T6681	amod	cytoskeletal,elements
R3979	T6683	T6678	advmod	also,increased
R398	T1016	T1017	prep	In,appears
R3980	T6684	T6678	aux	were,increased
R3981	T6685	T6686	punct	(,protein
R3982	T6686	T6678	parataxis	protein,increased
R3983	T6687	T6686	advmod	e.g.,protein
R3984	T6688	T6689	npadvmod	microtubule,associated
R3985	T6689	T6686	amod	associated,protein
R3986	T6690	T6686	nummod	4,protein
R3987	T6691	T6686	punct	),protein
R3988	T6692	T6678	cc	or,increased
R3989	T6693	T6678	conj	decreased,increased
R399	T1018	T1019	compound	rod,photoreceptors
R3990	T6694	T6695	punct	(,cofilin
R3991	T6695	T6693	parataxis	cofilin,decreased
R3992	T6696	T6695	advmod	e.g.,cofilin
R3993	T6697	T6695	nummod	1,cofilin
R3994	T6698	T6695	punct	),cofilin
R3995	T6699	T6678	prep	in,increased
R3996	T6700	T6701	det	the,retina
R3997	T6701	T6699	pobj	retina,in
R3998	T6702	T6701	nmod	Crx,retina
R3999	T6703	T6702	punct	-,Crx
R40	T159	T158	amod	early,onset
R400	T1019	T1016	pobj	photoreceptors,In
R4000	T6704	T6702	punct	/,Crx
R4001	T6705	T6702	punct	-,Crx
R4002	T6706	T6678	punct	", ",increased
R4003	T6707	T6678	prep	with,increased
R4004	T6708	T6709	compound	P,values
R4005	T6709	T6707	pobj	values,with
R4006	T6710	T6709	prep	of,values
R4007	T6711	T6712	punct	<,.005
R4008	T6712	T6710	pobj	.005,of
R4009	T6713	T6678	punct	.,increased
R401	T1020	T1017	punct	", ",appears
R4010	T6715	T6716	nsubjpass	It,known
R4011	T6717	T6716	auxpass	is,known
R4012	T6718	T6716	neg	not,known
R4013	T6719	T6720	mark	whether,involved
R4014	T6720	T6716	ccomp	involved,known
R4015	T6721	T6720	nsubjpass	any,involved
R4016	T6722	T6721	prep	of,any
R4017	T6723	T6724	det	these,genes
R4018	T6724	T6722	pobj	genes,of
R4019	T6725	T6720	auxpass	are,involved
R402	T1021	T1017	nsubj	Crx,appears
R4020	T6726	T6720	prep	in,involved
R4021	T6727	T6726	pcomp	building,in
R4022	T6728	T6727	cc	or,building
R4023	T6729	T6727	conj	regulating,building
R4024	T6730	T6731	amod	synaptic,structures
R4025	T6731	T6729	dobj	structures,regulating
R4026	T6732	T6716	punct	", ",known
R4027	T6733	T6716	cc	but,known
R4028	T6734	T6735	nsubj	they,are
R4029	T6735	T6716	conj	are,known
R403	T1022	T1023	aux	to,work
R4030	T6736	T6735	advmod	now,are
R4031	T6737	T6735	attr	genes,are
R4032	T6738	T6739	dep	that,lead
R4033	T6739	T6737	relcl	lead,genes
R4034	T6740	T6739	aux	might,lead
R4035	T6741	T6739	prep	to,lead
R4036	T6742	T6743	det	a,understanding
R4037	T6743	T6741	pobj	understanding,to
R4038	T6744	T6743	amod	better,understanding
R4039	T6745	T6743	prep	of,understanding
R404	T1023	T1017	xcomp	work,appears
R4040	T6746	T6747	det	the,construction
R4041	T6747	T6745	pobj	construction,of
R4042	T6748	T6747	cc	and,construction
R4043	T6749	T6747	conj	function,construction
R4044	T6750	T6747	prep	of,construction
R4045	T6751	T6752	det	the,structure
R4046	T6752	T6750	pobj	structure,of
R4047	T6753	T6754	advmod	relatively,unique
R4048	T6754	T6752	amod	unique,structure
R4049	T6755	T6752	prep	of,structure
R405	T1024	T1023	prep	in,work
R4050	T6756	T6757	det	the,synapse
R4051	T6757	T6755	pobj	synapse,of
R4052	T6758	T6757	compound	ribbon,synapse
R4053	T6759	T6735	punct	.,are
R4054	T6761	T6762	amod	Abnormal,formation
R4055	T6762	T6765	nsubjpass	formation,noted
R4056	T6763	T6764	compound	photoreceptor,terminal
R4057	T6764	T6762	compound	terminal,formation
R4058	T6766	T6765	auxpass	was,noted
R4059	T6767	T6765	prep	in,noted
R406	T1025	T1024	pobj	concert,in
R4060	T6768	T6769	det	a,study
R4061	T6769	T6767	pobj	study,in
R4062	T6770	T6771	dep	that,examined
R4063	T6771	T6769	relcl	examined,study
R4064	T6772	T6773	amod	retinal,development
R4065	T6773	T6771	dobj	development,examined
R4066	T6774	T6771	prep	in,examined
R4067	T6775	T6776	det	the,mouse
R4068	T6776	T6774	pobj	mouse,in
R4069	T6777	T6778	compound	laminin,chain
R407	T1026	T1025	prep	with,concert
R4070	T6778	T6780	npadvmod	chain,deficient
R4071	T6779	T6778	compound	beta2,chain
R4072	T6780	T6776	amod	deficient,mouse
R4073	T6781	T6780	punct	-,deficient
R4074	T6782	T6783	punct	[,52
R4075	T6783	T6765	parataxis	52,noted
R4076	T6784	T6783	punct	],52
R4077	T6785	T6765	punct	.,noted
R4078	T6787	T6788	amod	Several,pathologies
R4079	T6788	T6789	nsubjpass	pathologies,noted
R408	T1027	T1026	pobj	Nrl,with
R4080	T6790	T6789	auxpass	were,noted
R4081	T6791	T6789	prep	in,noted
R4082	T6792	T6793	det	these,mice
R4083	T6793	T6791	pobj	mice,in
R4084	T6794	T6789	punct	.,noted
R4085	T6796	T6797	advmod	First,displayed
R4086	T6797	T6805	ccomp	displayed,reduced
R4087	T6798	T6797	punct	", ",displayed
R4088	T6799	T6800	compound	laminin,chain
R4089	T6800	T6802	npadvmod	chain,deficient
R409	T1028	T1027	punct	", ",Nrl
R4090	T6801	T6800	compound	beta2,chain
R4091	T6802	T6804	amod	deficient,mice
R4092	T6803	T6802	punct	-,deficient
R4093	T6804	T6797	nsubj	mice,displayed
R4094	T6806	T6807	amod	abnormal,elongation
R4095	T6807	T6797	dobj	elongation,displayed
R4096	T6808	T6809	amod	outer,segment
R4097	T6809	T6807	compound	segment,elongation
R4098	T6810	T6807	punct	", ",elongation
R4099	T6811	T6807	cc	but,elongation
R41	T161	T162	amod	abnormal,development
R410	T1029	T1030	det	a,protein
R4100	T6812	T6813	det	a,phenotype
R4101	T6813	T6807	conj	phenotype,elongation
R4102	T6814	T6815	advmod	more,mild
R4103	T6815	T6813	nmod	mild,phenotype
R4104	T6816	T6813	prep	than,phenotype
R4105	T6817	T6816	pobj	that,than
R4106	T6818	T6817	prep	of,that
R4107	T6819	T6820	det	the,mice
R4108	T6820	T6818	pobj	mice,of
R4109	T6821	T6820	nmod	Crx,mice
R411	T1030	T1027	appos	protein,Nrl
R4110	T6822	T6821	punct	-,Crx
R4111	T6823	T6821	punct	/,Crx
R4112	T6824	T6821	punct	-,Crx
R4113	T6825	T6805	punct	;,reduced
R4114	T6826	T6827	det	the,segments
R4115	T6827	T6805	nsubjpass	segments,reduced
R4116	T6828	T6827	amod	outer,segments
R4117	T6829	T6805	auxpass	were,reduced
R4118	T6830	T6805	prep	by,reduced
R4119	T6831	T6832	nummod	50,%
R412	T1031	T1032	compound	leucine,zipper
R4120	T6832	T6830	pobj	%,by
R4121	T6833	T6805	prep	in,reduced
R4122	T6834	T6833	pobj	length,in
R4123	T6835	T6805	punct	.,reduced
R4124	T6837	T6838	advmod	Also,perturbed
R4125	T6839	T6840	compound	photoreceptor,terminals
R4126	T6840	T6838	nsubjpass	terminals,perturbed
R4127	T6841	T6838	auxpass	were,perturbed
R4128	T6842	T6838	prep	in,perturbed
R4129	T6843	T6844	compound	laminin,beta2
R413	T1032	T1030	compound	zipper,protein
R4130	T6844	T6845	compound	beta2,mutants
R4131	T6845	T6842	pobj	mutants,in
R4132	T6846	T6838	punct	", ",perturbed
R4133	T6847	T6838	cc	but,perturbed
R4134	T6848	T6849	advmod	again,was
R4135	T6849	T6838	conj	was,perturbed
R4136	T6850	T6851	det	the,phenotype
R4137	T6851	T6849	nsubj	phenotype,was
R4138	T6852	T6853	advmod	more,subtle
R4139	T6853	T6849	acomp	subtle,was
R414	T1033	T1034	dep	that,restricted
R4140	T6854	T6853	prep	then,subtle
R4141	T6855	T6854	pobj	that,then
R4142	T6856	T6855	prep	of,that
R4143	T6857	T6858	nmod	Crx,mice
R4144	T6858	T6856	pobj	mice,of
R4145	T6859	T6857	punct	-,Crx
R4146	T6860	T6857	punct	/,Crx
R4147	T6861	T6857	punct	-,Crx
R4148	T6862	T6849	punct	.,was
R4149	T6864	T6865	det	The,layer
R415	T1034	T1030	relcl	restricted,protein
R4150	T6865	T6868	nsubj	layer,demonstrated
R4151	T6866	T6867	amod	outer,plexiform
R4152	T6867	T6865	compound	plexiform,layer
R4153	T6869	T6865	prep	of,layer
R4154	T6870	T6871	det	the,retinas
R4155	T6871	T6869	pobj	retinas,of
R4156	T6872	T6873	npadvmod	beta2,deficient
R4157	T6873	T6871	amod	deficient,retinas
R4158	T6874	T6873	punct	-,deficient
R4159	T6875	T6876	advmod	only,7
R416	T1035	T1034	auxpass	is,restricted
R4160	T6876	T6877	nummod	7,%
R4161	T6877	T6878	nmod	%,synapses
R4162	T6878	T6868	dobj	synapses,demonstrated
R4163	T6879	T6878	amod	normal,synapses
R4164	T6880	T6878	amod	invaginating,synapses
R4165	T6881	T6868	punct	", ",demonstrated
R4166	T6882	T6883	mark	while,had
R4167	T6883	T6868	advcl	had,demonstrated
R4168	T6884	T6885	det	the,remainder
R4169	T6885	T6883	nsubj	remainder,had
R417	T1036	T1034	advmod	also,restricted
R4170	T6886	T6887	amod	various,pathologies
R4171	T6887	T6883	dobj	pathologies,had
R4172	T6888	T6887	punct	", ",pathologies
R4173	T6889	T6887	prep	including,pathologies
R4174	T6890	T6891	amod	floating,ribbons
R4175	T6891	T6889	pobj	ribbons,including
R4176	T6892	T6891	amod	synaptic,ribbons
R4177	T6893	T6883	punct	", ",had
R4178	T6894	T6895	mark	as,seen
R4179	T6895	T6883	advcl	seen,had
R418	T1037	T1034	prep	in,restricted
R4180	T6896	T6895	advmod	here,seen
R4181	T6897	T6868	punct	.,demonstrated
R4182	T6899	T6900	det	The,relationship
R4183	T6900	T6902	nsubj	relationship,is
R4184	T6901	T6900	amod	mechanistic,relationship
R4185	T6903	T6900	prep	of,relationship
R4186	T6904	T6905	det	these,molecules
R4187	T6905	T6903	pobj	molecules,of
R4188	T6906	T6905	nummod	two,molecules
R4189	T6907	T6908	punct	", ",any
R419	T1038	T1039	poss	its,expression
R4190	T6908	T6900	parataxis	any,relationship
R4191	T6909	T6908	mark	if,any
R4192	T6910	T6908	punct	", ",any
R4193	T6911	T6900	prep	in,relationship
R4194	T6912	T6913	compound	photoreceptor,morphogenesis
R4195	T6913	T6911	pobj	morphogenesis,in
R4196	T6914	T6902	acomp	unknown,is
R4197	T6915	T6902	prep	to,is
R4198	T6916	T6915	pobj	date,to
R4199	T6917	T6902	punct	.,is
R42	T162	T160	dobj	development,suggests
R420	T1039	T1037	pobj	expression,in
R4200	T6919	T6920	det	The,mRNA
R4201	T6920	T6921	nsubjpass	mRNA,detected
R4202	T6922	T6920	prep	for,mRNA
R4203	T6923	T6924	compound	laminin,beta2
R4204	T6924	T6922	pobj	beta2,for
R4205	T6925	T6921	auxpass	was,detected
R4206	T6926	T6921	neg	not,detected
R4207	T6927	T6921	prep	in,detected
R4208	T6928	T6929	det	the,study
R4209	T6929	T6927	pobj	study,in
R421	T1040	T1039	prep	in,expression
R4210	T6930	T6929	compound	SAGE,study
R4211	T6931	T6929	prep	of,study
R4212	T6932	T6933	det	the,levels
R4213	T6933	T6931	pobj	levels,of
R4214	T6934	T6933	amod	relative,levels
R4215	T6935	T6933	compound	RNA,levels
R4216	T6936	T6933	prep	in,levels
R4217	T6937	T6936	pobj	Crx,in
R4218	T6938	T6937	punct	-,Crx
R4219	T6939	T6937	punct	/,Crx
R422	T1041	T1042	det	the,retina
R4220	T6940	T6937	punct	-,Crx
R4221	T6941	T6937	cc	and,Crx
R4222	T6942	T6937	conj	Crx,Crx
R4223	T6943	T6942	punct	+,Crx
R4224	T6944	T6942	punct	/,Crx
R4225	T6945	T6942	punct	+,Crx
R4226	T6946	T6921	cc	and,detected
R4227	T6947	T6948	advmod	thus,comment
R4228	T6948	T6921	conj	comment,detected
R4229	T6949	T6948	nsubj	we,comment
R423	T1042	T1040	pobj	retina,in
R4230	T6950	T6948	aux	can,comment
R4231	T6951	T6948	neg	not,comment
R4232	T6952	T6948	prep	on,comment
R4233	T6953	T6954	mark	whether,altered
R4234	T6954	T6952	pcomp	altered,on
R4235	T6955	T6956	det	the,levels
R4236	T6956	T6954	nsubjpass	levels,altered
R4237	T6957	T6956	prep	of,levels
R4238	T6958	T6957	pobj	RNA,of
R4239	T6959	T6956	prep	for,levels
R424	T1043	T1034	prep	to,restricted
R4240	T6960	T6961	compound	laminin,beta2
R4241	T6961	T6959	pobj	beta2,for
R4242	T6962	T6954	auxpass	were,altered
R4243	T6963	T6948	punct	.,comment
R4246	T7157	T7158	nmod	Crx,mice
R4247	T7158	T7162	nsubj	mice,are
R4248	T7159	T7157	punct	-,Crx
R4249	T7160	T7157	punct	/,Crx
R425	T1044	T1045	compound	rod,photoreceptors
R4250	T7161	T7157	punct	-,Crx
R4251	T7163	T7164	det	a,model
R4252	T7164	T7162	attr	model,are
R4253	T7165	T7164	prep	for,model
R4254	T7166	T7165	pobj	LCA,for
R4255	T7168	T7169	nsubjpass	Crx,implicated
R4256	T7170	T7169	aux	has,implicated
R4257	T7171	T7169	auxpass	been,implicated
R4258	T7172	T7169	prep	in,implicated
R4259	T7173	T7174	nummod	three,diseases
R426	T1045	T1043	pobj	photoreceptors,to
R4260	T7174	T7172	pobj	diseases,in
R4261	T7175	T7174	compound	photoreceptor,diseases
R4262	T7176	T7177	dep	that,result
R4263	T7177	T7174	relcl	result,diseases
R4264	T7178	T7177	prep	in,result
R4265	T7179	T7180	amod	human,blindness
R4266	T7180	T7178	pobj	blindness,in
R4267	T7181	T7180	punct	", ",blindness
R4268	T7182	T7183	compound	cone,rod
R4269	T7183	T7185	compound	rod,dystrophy2
R427	T1046	T1047	punct	[,9
R4270	T7184	T7183	punct	-,rod
R4271	T7185	T7180	conj	dystrophy2,blindness
R4272	T7186	T7185	punct	", ",dystrophy2
R4273	T7187	T7188	poss	Leber,amaurosis
R4274	T7188	T7185	conj	amaurosis,dystrophy2
R4275	T7189	T7187	case	's,Leber
R4276	T7190	T7188	amod	congenital,amaurosis
R4277	T7191	T7188	punct	", ",amaurosis
R4278	T7192	T7188	cc	and,amaurosis
R4279	T7193	T7194	compound	retinitis,pigmentosa
R428	T1047	T1034	parataxis	9,restricted
R4280	T7194	T7188	conj	pigmentosa,amaurosis
R4281	T7195	T7196	punct	(,see
R4282	T7196	T7169	parataxis	see,implicated
R4283	T7197	T7196	prep	for,see
R4284	T7198	T7197	pobj	review,for
R4285	T7199	T7196	punct	", ",see
R4286	T7200	T7196	punct	[,see
R4287	T7201	T7196	dobj	53,see
R4288	T7202	T7196	punct	],see
R4289	T7203	T7196	punct	),see
R429	T1048	T1047	punct	],9
R4290	T7204	T7169	punct	.,implicated
R4291	T7206	T7207	det	The,dystrophies
R4292	T7207	T7211	nsubjpass	dystrophies,characterized
R4293	T7208	T7209	compound	cone,rod
R4294	T7209	T7207	compound	rod,dystrophies
R4295	T7210	T7209	punct	-,rod
R4296	T7212	T7207	punct	(,dystrophies
R4297	T7213	T7207	appos	CRDs,dystrophies
R4298	T7214	T7207	punct	),dystrophies
R4299	T7215	T7211	auxpass	are,characterized
R43	T163	T162	prep	of,development
R430	T1049	T1017	punct	.,appears
R4300	T7216	T7211	agent	by,characterized
R4301	T7217	T7216	pobj	loss,by
R4302	T7218	T7217	prep	of,loss
R4303	T7219	T7220	npadvmod	cone,mediated
R4304	T7220	T7222	amod	mediated,vision
R4305	T7221	T7220	punct	-,mediated
R4306	T7222	T7218	pobj	vision,of
R4307	T7223	T7211	prep	in,characterized
R4308	T7224	T7225	det	the,decade
R4309	T7225	T7223	pobj	decade,in
R431	T1051	T1052	amod	Many,genes
R4310	T7226	T7225	amod	first,decade
R4311	T7227	T7225	prep	of,decade
R4312	T7228	T7227	pobj	life,of
R4313	T7229	T7211	cc	or,characterized
R4314	T7230	T7231	advmod	later,with
R4315	T7231	T7211	conj	with,characterized
R4316	T7232	T7231	punct	", ",with
R4317	T7233	T7234	amod	concomitant,loss
R4318	T7234	T7231	pobj	loss,with
R4319	T7235	T7233	cc	or,concomitant
R432	T1052	T1056	nsubj	genes,have
R4320	T7236	T7233	conj	subsequent,concomitant
R4321	T7237	T7234	prep	of,loss
R4322	T7238	T7239	npadvmod	rod,mediated
R4323	T7239	T7241	amod	mediated,vision
R4324	T7240	T7239	punct	-,mediated
R4325	T7241	T7237	pobj	vision,of
R4326	T7242	T7243	punct	[,54
R4327	T7243	T7231	parataxis	54,with
R4328	T7244	T7243	punct	],54
R4329	T7245	T7211	punct	.,characterized
R433	T1053	T1054	npadvmod	photoreceptor,specific
R4330	T7247	T7248	advmod	Conversely,is
R4331	T7249	T7248	punct	", ",is
R4332	T7250	T7248	nsubj	RP,is
R4333	T7251	T7248	acomp	notable,is
R4334	T7252	T7251	prep	for,notable
R4335	T7253	T7254	amod	initial,loss
R4336	T7254	T7252	pobj	loss,for
R4337	T7255	T7254	prep	of,loss
R4338	T7256	T7257	compound	rod,function
R4339	T7257	T7255	pobj	function,of
R434	T1054	T1052	amod	specific,genes
R4340	T7258	T7254	punct	", ",loss
R4341	T7259	T7254	acl	followed,loss
R4342	T7260	T7259	agent	by,followed
R4343	T7261	T7260	pobj	loss,by
R4344	T7262	T7261	prep	of,loss
R4345	T7263	T7264	npadvmod	cone,mediated
R4346	T7264	T7266	amod	mediated,vision
R4347	T7265	T7264	punct	-,mediated
R4348	T7266	T7262	pobj	vision,of
R4349	T7267	T7268	punct	[,55
R435	T1055	T1054	punct	-,specific
R4350	T7268	T7248	parataxis	55,is
R4351	T7269	T7268	punct	],55
R4352	T7270	T7248	punct	.,is
R4353	T7272	T7273	det	The,majority
R4354	T7273	T7274	nsubj	majority,encode
R4355	T7275	T7273	prep	of,majority
R4356	T7276	T7277	amod	known,genes
R4357	T7277	T7275	pobj	genes,of
R4358	T7278	T7277	amod	responsible,genes
R4359	T7279	T7278	prep	for,responsible
R436	T1057	T1058	amod	putative,elements
R4360	T7280	T7281	amod	human,blindness
R4361	T7281	T7279	pobj	blindness,for
R4362	T7282	T7281	amod	genetic,blindness
R4363	T7283	T7274	punct	", ",encode
R4364	T7284	T7274	dobj	proteins,encode
R4365	T7285	T7284	acl	expressed,proteins
R4366	T7286	T7287	advmod	almost,exclusively
R4367	T7287	T7288	advmod	exclusively,in
R4368	T7288	T7285	prep	in,expressed
R4369	T7289	T7287	punct	", ",exclusively
R437	T1058	T1056	dobj	elements,have
R4370	T7290	T7287	cc	or,exclusively
R4371	T7291	T7287	conj	exclusively,exclusively
R4372	T7292	T7288	punct	", ",in
R4373	T7293	T7288	pobj	photoreceptors,in
R4374	T7294	T7293	punct	", ",photoreceptors
R4375	T7295	T7296	advmod	particularly,in
R4376	T7296	T7293	prep	in,photoreceptors
R4377	T7297	T7298	det	the,segment
R4378	T7298	T7296	pobj	segment,in
R4379	T7299	T7298	amod	outer,segment
R438	T1059	T1060	npadvmod	Crx,binding
R4380	T7300	T7301	punct	[,35
R4381	T7301	T7274	parataxis	35,encode
R4382	T7302	T7301	punct	],35
R4383	T7303	T7274	punct	.,encode
R4384	T7305	T7306	nsubjpass	Many,required
R4385	T7307	T7305	prep	of,Many
R4386	T7308	T7309	det	these,proteins
R4387	T7309	T7307	pobj	proteins,of
R4388	T7310	T7306	auxpass	are,required
R4389	T7311	T7306	prep	for,required
R439	T1060	T1058	amod	binding,elements
R4390	T7312	T7311	pobj	phototransduction,for
R4391	T7313	T7312	cc	or,phototransduction
R4392	T7314	T7315	amod	outer,segment
R4393	T7315	T7316	compound	segment,structure
R4394	T7316	T7312	conj	structure,phototransduction
R4395	T7317	T7306	punct	.,required
R4396	T7319	T7320	det	The,mechanisms
R4397	T7320	T7321	nsubj	mechanisms,remain
R4398	T7322	T7323	advmod	whereby,lead
R4399	T7323	T7320	relcl	lead,mechanisms
R44	T164	T165	det	the,retina
R440	T1061	T1060	punct	-,binding
R4400	T7324	T7323	nsubj	mutations,lead
R4401	T7325	T7324	prep	in,mutations
R4402	T7326	T7327	npadvmod	rod,specific
R4403	T7327	T7329	amod	specific,genes
R4404	T7328	T7327	punct	-,specific
R4405	T7329	T7325	pobj	genes,in
R4406	T7330	T7329	punct	", ",genes
R4407	T7331	T7332	amod	such,as
R4408	T7332	T7329	prep	as,genes
R4409	T7333	T7332	pobj	rhodopsin,as
R441	T1062	T1056	prep	in,have
R4410	T7334	T7323	punct	", ",lead
R4411	T7335	T7323	advmod	eventually,lead
R4412	T7336	T7323	prep	to,lead
R4413	T7337	T7338	compound	cone,degeneration
R4414	T7338	T7336	pobj	degeneration,to
R4415	T7339	T7323	prep	in,lead
R4416	T7340	T7339	pobj	RP,in
R4417	T7341	T7321	acomp	obscure,remain
R4418	T7342	T7321	punct	.,remain
R4419	T7344	T7345	nsubj	Mutations,were
R442	T1063	T1064	poss	their,regions
R4420	T7346	T7344	prep	in,Mutations
R4421	T7347	T7346	pobj	Crx,in
R4422	T7348	T7349	det	the,first
R4423	T7349	T7345	attr	first,were
R4424	T7350	T7349	punct	", ",first
R4425	T7351	T7349	cc	and,first
R4426	T7352	T7353	advmod	still,one
R4427	T7353	T7354	nummod	one,examples
R4428	T7354	T7349	conj	examples,first
R4429	T7355	T7353	prep	of,one
R443	T1064	T1062	pobj	regions,in
R4430	T7356	T7357	det	a,few
R4431	T7357	T7355	pobj	few,of
R4432	T7358	T7357	advmod	very,few
R4433	T7359	T7349	prep	of,first
R4434	T7360	T7361	det	a,mutation
R4435	T7361	T7359	pobj	mutation,of
R4436	T7362	T7363	compound	transcription,factor
R4437	T7363	T7361	compound	factor,mutation
R4438	T7364	T7361	acl	leading,mutation
R4439	T7365	T7364	prep	to,leading
R444	T1065	T1064	amod	regulatory,regions
R4440	T7366	T7367	compound	photoreceptor,disease
R4441	T7367	T7365	pobj	disease,to
R4442	T7368	T7345	punct	.,were
R4443	T7370	T7371	nsubj	LCA,is
R4444	T7372	T7373	det	a,disease
R4445	T7373	T7371	attr	disease,is
R4446	T7374	T7375	prep	in,is
R4447	T7375	T7373	relcl	is,disease
R4448	T7376	T7374	pobj	which,in
R4449	T7377	T7375	expl	there,is
R445	T1066	T1067	punct	[,10
R4450	T7378	T7379	amod	little,function
R4451	T7379	T7375	attr	function,is
R4452	T7380	T7378	cc	or,little
R4453	T7381	T7378	conj	no,little
R4454	T7382	T7379	compound	photoreceptor,function
R4455	T7383	T7375	prep	in,is
R4456	T7384	T7383	pobj	infancy,in
R4457	T7385	T7373	punct	;,disease
R4458	T7386	T7387	advmod	thereby,developmental
R4459	T7387	T7373	conj	developmental,disease
R446	T1067	T1056	parataxis	10,have
R4460	T7388	T7387	punct	", ",developmental
R4461	T7389	T7387	advmod	likely,developmental
R4462	T7390	T7387	prep	in,developmental
R4463	T7391	T7390	pobj	etiology,in
R4464	T7392	T7393	punct	(,56
R4465	T7393	T7371	parataxis	56,is
R4466	T7394	T7393	punct	[,56
R4467	T7395	T7393	nummod	17,56
R4468	T7396	T7393	punct	",",56
R4469	T7397	T7393	punct	],56
R447	T1068	T1067	punct	],10
R4470	T7398	T7393	prep	for,56
R4471	T7399	T7398	pobj	review,for
R4472	T7400	T7393	punct	),56
R4473	T7401	T7371	punct	.,is
R4474	T7403	T7404	det	The,mouse
R4475	T7404	T7409	nsubj	mouse,be
R4476	T7405	T7404	nmod	Crx,mouse
R4477	T7406	T7405	punct	-,Crx
R4478	T7407	T7405	punct	/,Crx
R4479	T7408	T7405	punct	-,Crx
R448	T1069	T1056	punct	", ",have
R4480	T7410	T7409	aux	may,be
R4481	T7411	T7412	det	an,model
R4482	T7412	T7409	attr	model,be
R4483	T7413	T7412	amod	excellent,model
R4484	T7414	T7412	prep	for,model
R4485	T7415	T7414	pcomp	studying,for
R4486	T7416	T7417	det	the,pathology
R4487	T7417	T7415	dobj	pathology,studying
R4488	T7418	T7417	prep	of,pathology
R4489	T7419	T7420	det	this,disorder
R449	T1070	T1056	prep	including,have
R4490	T7420	T7418	pobj	disorder,of
R4491	T7421	T7420	punct	", ",disorder
R4492	T7422	T7423	advmod	particularly,subtype
R4493	T7423	T7420	appos	subtype,disorder
R4494	T7424	T7423	det	the,subtype
R4495	T7425	T7423	prep	of,subtype
R4496	T7426	T7427	det	the,disorder
R4497	T7427	T7425	pobj	disorder,of
R4498	T7428	T7429	advmod	where,involved
R4499	T7429	T7423	relcl	involved,subtype
R45	T165	T163	pobj	retina,of
R450	T1071	T1070	pobj	rhodopsin,including
R4500	T7430	T7431	compound	Crx,mutations
R4501	T7431	T7429	nsubjpass	mutations,involved
R4502	T7432	T7429	auxpass	are,involved
R4503	T7433	T7409	punct	.,be
R4504	T7435	T7436	det	The,majority
R4505	T7436	T7438	nsubjpass	majority,derived
R4506	T7437	T7436	amod	vast,majority
R4507	T7439	T7436	prep	of,majority
R4508	T7440	T7441	amod	histopathological,studies
R4509	T7441	T7439	pobj	studies,of
R451	T1072	T1073	punct	[,11
R4510	T7442	T7441	prep	of,studies
R4511	T7443	T7442	pobj	LCA,of
R4512	T7444	T7441	prep	in,studies
R4513	T7445	T7446	amod	human,tissue
R4514	T7446	T7444	pobj	tissue,in
R4515	T7447	T7438	aux	have,derived
R4516	T7448	T7438	auxpass	been,derived
R4517	T7449	T7438	prep	from,derived
R4518	T7450	T7451	amod	adult,patients
R4519	T7451	T7449	pobj	patients,from
R452	T1073	T1071	parataxis	11,rhodopsin
R4520	T7452	T7451	prep	with,patients
R4521	T7453	T7452	pobj	LCA,with
R4522	T7454	T7455	advmod	where,are
R4523	T7455	T7451	relcl	are,patients
R4524	T7456	T7457	amod	secondary,changes
R4525	T7457	T7455	nsubj	changes,are
R4526	T7458	T7455	acomp	likely,are
R4527	T7459	T7460	aux	to,be
R4528	T7460	T7458	xcomp	be,likely
R4529	T7461	T7460	acomp	present,be
R453	T1074	T1073	punct	],11
R4530	T7462	T7438	punct	.,derived
R4531	T7464	T7465	advmod	Indeed,occur
R4532	T7466	T7465	prep	in,occur
R4533	T7467	T7468	compound	animal,models
R4534	T7468	T7466	pobj	models,in
R4535	T7469	T7468	prep	of,models
R4536	T7470	T7469	pobj	LCA,of
R4537	T7471	T7465	punct	", ",occur
R4538	T7472	T7473	amod	secondary,changes
R4539	T7473	T7465	nsubj	changes,occur
R454	T1075	T1071	cc	and,rhodopsin
R4540	T7474	T7473	amod	reactive,changes
R4541	T7475	T7474	cc	and,reactive
R4542	T7476	T7475	punct	/,and
R4543	T7477	T7475	cc	or,and
R4544	T7478	T7474	conj	degenerative,reactive
R4545	T7479	T7480	advmod	early,after
R4546	T7480	T7465	prep	after,occur
R4547	T7481	T7482	det	the,formation
R4548	T7482	T7480	pobj	formation,after
R4549	T7483	T7482	amod	abnormal,formation
R455	T1076	T1071	conj	arrestin,rhodopsin
R4550	T7484	T7482	prep	of,formation
R4551	T7485	T7486	amod	retinal,tissue
R4552	T7486	T7484	pobj	tissue,of
R4553	T7487	T7488	punct	[,57
R4554	T7488	T7465	parataxis	57,occur
R4555	T7489	T7488	punct	],57
R4556	T7490	T7465	punct	.,occur
R4557	T7492	T7493	det	The,study
R4558	T7493	T7495	nsubjpass	study,reported
R4559	T7494	T7493	amod	only,study
R456	T1077	T1078	punct	[,12
R4560	T7496	T7493	prep	in,study
R4561	T7497	T7498	amod	human,tissue
R4562	T7498	T7496	pobj	tissue,in
R4563	T7499	T7498	acl	derived,tissue
R4564	T7500	T7499	prep	from,derived
R4565	T7501	T7502	det	a,retina
R4566	T7502	T7500	pobj	retina,from
R4567	T7503	T7502	amod	human,retina
R4568	T7504	T7505	nummod	33,week
R4569	T7505	T7502	compound	week,retina
R457	T1078	T1076	parataxis	12,arrestin
R4570	T7506	T7505	punct	-,week
R4571	T7507	T7502	prep	with,retina
R4572	T7508	T7509	amod	proposed,mutations
R4573	T7509	T7507	pobj	mutations,with
R4574	T7510	T7509	compound	RPE65,mutations
R4575	T7511	T7495	auxpass	was,reported
R4576	T7512	T7513	aux	to,have
R4577	T7513	T7495	xcomp	have,reported
R4578	T7514	T7515	amod	abnormal,retinae
R4579	T7515	T7513	dobj	retinae,have
R458	T1079	T1078	punct	],12
R4580	T7516	T7513	prep	at,have
R4581	T7517	T7518	det	this,stage
R4582	T7518	T7516	pobj	stage,at
R4583	T7519	T7518	amod	early,stage
R4584	T7520	T7521	punct	[,24
R4585	T7521	T7495	parataxis	24,reported
R4586	T7522	T7521	punct	],24
R4587	T7523	T7495	punct	.,reported
R4588	T7525	T7526	det	These,authors
R4589	T7526	T7527	nsubj	authors,report
R459	T1080	T1056	punct	.,have
R4590	T7528	T7529	compound	cell,loss
R4591	T7529	T7527	dobj	loss,report
R4592	T7530	T7529	punct	", ",loss
R4593	T7531	T7529	prep	including,loss
R4594	T7532	T7531	pobj	thinning,including
R4595	T7533	T7532	prep	of,thinning
R4596	T7534	T7535	det	the,layer
R4597	T7535	T7533	pobj	layer,of
R4598	T7536	T7535	compound	photoreceptor,layer
R4599	T7537	T7527	punct	.,report
R46	T166	T165	amod	neural,retina
R460	T1082	T1083	nsubjpass	Mutations,associated
R4600	T7539	T7540	prep	In,claim
R4601	T7541	T7539	pobj	addition,In
R4602	T7542	T7540	punct	", ",claim
R4603	T7543	T7540	nsubj	they,claim
R4604	T7544	T7540	prep	in,claim
R4605	T7545	T7546	det	the,text
R4606	T7546	T7544	pobj	text,in
R4607	T7547	T7548	aux	to,seen
R4608	T7548	T7540	xcomp	seen,claim
R4609	T7549	T7548	aux	have,seen
R461	T1084	T1082	prep	in,Mutations
R4610	T7550	T7551	amod	aberrant,organization
R4611	T7551	T7548	dobj	organization,seen
R4612	T7552	T7551	amod	synaptic,organization
R4613	T7553	T7552	cc	and,synaptic
R4614	T7554	T7555	amod	inner,retinal
R4615	T7555	T7552	conj	retinal,synaptic
R4616	T7556	T7548	punct	", ",seen
R4617	T7557	T7558	mark	although,presented
R4618	T7558	T7548	advcl	presented,seen
R4619	T7559	T7560	poss	their,examination
R462	T1085	T1084	pobj	Crx,in
R4620	T7560	T7558	nsubjpass	examination,presented
R4621	T7561	T7560	prep	of,examination
R4622	T7562	T7563	compound	photoreceptor,synapses
R4623	T7563	T7561	pobj	synapses,of
R4624	T7564	T7558	advmod	unfortunately,presented
R4625	T7565	T7558	auxpass	are,presented
R4626	T7566	T7558	neg	not,presented
R4627	T7567	T7558	prep	in,presented
R4628	T7568	T7569	det	the,section
R4629	T7569	T7567	pobj	section,in
R463	T1086	T1083	aux	have,associated
R4630	T7570	T7569	compound	data,section
R4631	T7571	T7569	prep	of,section
R4632	T7572	T7573	det	the,paper
R4633	T7573	T7571	pobj	paper,of
R4634	T7574	T7540	punct	.,claim
R4635	T7576	T7577	prep	Given,require
R4636	T7578	T7579	det	the,scarcity
R4637	T7579	T7576	pobj	scarcity,Given
R4638	T7580	T7579	prep	of,scarcity
R4639	T7581	T7582	amod	available,tissue
R464	T1087	T1083	auxpass	been,associated
R4640	T7582	T7580	pobj	tissue,of
R4641	T7583	T7582	amod	human,tissue
R4642	T7584	T7577	punct	", ",require
R4643	T7585	T7586	det	the,characterization
R4644	T7586	T7577	nsubj	characterization,require
R4645	T7587	T7586	prep	of,characterization
R4646	T7588	T7589	det	the,pathology
R4647	T7589	T7587	pobj	pathology,of
R4648	T7590	T7589	amod	primary,pathology
R4649	T7591	T7589	prep	of,pathology
R465	T1088	T1083	prep	with,associated
R4650	T7592	T7591	pobj	LCA,of
R4651	T7593	T7577	aux	will,require
R4652	T7594	T7595	compound	animal,models
R4653	T7595	T7577	dobj	models,require
R4654	T7596	T7577	punct	.,require
R4655	T7598	T7599	prep	In,present
R4656	T7600	T7601	det	the,study
R4657	T7601	T7598	pobj	study,In
R4658	T7602	T7601	amod	current,study
R4659	T7603	T7599	punct	", ",present
R466	T1089	T1090	amod	several,diseases
R4660	T7604	T7599	nsubj	we,present
R4661	T7605	T7599	dobj	data,present
R4662	T7606	T7607	dep	that,argue
R4663	T7607	T7605	relcl	argue,data
R4664	T7608	T7609	mark	that,be
R4665	T7609	T7607	ccomp	be,argue
R4666	T7610	T7609	punct	", ",be
R4667	T7611	T7609	prep	in,be
R4668	T7612	T7611	pobj	addition,in
R4669	T7613	T7612	prep	to,addition
R467	T1090	T1088	pobj	diseases,with
R4670	T7614	T7615	amod	outer,segment
R4671	T7615	T7616	compound	segment,morphogenesis
R4672	T7616	T7613	pobj	morphogenesis,to
R4673	T7617	T7609	punct	", ",be
R4674	T7618	T7609	nsubj	synaptogenesis,be
R4675	T7619	T7609	aux	may,be
R4676	T7620	T7609	advmod	also,be
R4677	T7621	T7622	advmod	critically,impaired
R4678	T7622	T7609	acomp	impaired,be
R4679	T7623	T7609	prep	in,be
R468	T1091	T1090	amod	human,diseases
R4680	T7624	T7625	advmod	at,a
R4681	T7625	T7627	nummod	a,subset
R4682	T7626	T7625	advmod	least,a
R4683	T7627	T7623	pobj	subset,in
R4684	T7628	T7627	prep	of,subset
R4685	T7629	T7628	pobj	LCA,of
R4686	T7630	T7599	punct	.,present
R4687	T7658	T7659	nmod	Crx,mice
R4688	T7659	T7663	nsubjpass	mice,generated
R4689	T7660	T7658	punct	-,Crx
R469	T1092	T1093	dep	that,lead
R4690	T7661	T7658	punct	/,Crx
R4691	T7662	T7658	punct	-,Crx
R4692	T7664	T7663	auxpass	were,generated
R4693	T7665	T7666	mark	as,reported
R4694	T7666	T7663	advcl	reported,generated
R4695	T7667	T7666	advmod	elsewhere,reported
R4696	T7668	T7669	punct	[,34
R4697	T7669	T7663	parataxis	34,generated
R4698	T7670	T7669	punct	],34
R4699	T7671	T7663	punct	.,generated
R47	T167	T160	punct	.,suggests
R470	T1093	T1090	relcl	lead,diseases
R4700	T7673	T7674	npadvmod	Rhodosin,null
R4701	T7674	T7676	amod	null,mice
R4702	T7675	T7674	punct	-,null
R4703	T7676	T7677	nsubjpass	mice,obtained
R4704	T7678	T7679	punct	[,29
R4705	T7679	T7676	parataxis	29,mice
R4706	T7680	T7679	punct	],29
R4707	T7681	T7677	auxpass	were,obtained
R4708	T7682	T7677	prep	from,obtained
R4709	T7683	T7684	compound	Paul,Sieving
R471	T1094	T1093	prep	to,lead
R4710	T7684	T7682	pobj	Sieving,from
R4711	T7685	T7686	punct	(,University
R4712	T7686	T7677	parataxis	University,obtained
R4713	T7687	T7686	prep	of,University
R4714	T7688	T7687	pobj	Michigan,of
R4715	T7689	T7686	punct	),University
R4716	T7690	T7677	punct	.,obtained
R4717	T7692	T7693	compound	Rds,mice
R4718	T7693	T7694	nsubjpass	mice,acquired
R4719	T7695	T7694	auxpass	were,acquired
R472	T1095	T1094	pobj	blindness,to
R4720	T7696	T7694	prep	from,acquired
R4721	T7697	T7698	compound	Jackson,Laboratory
R4722	T7698	T7696	pobj	Laboratory,from
R4723	T7699	T7694	punct	.,acquired
R4724	T7779	T7780	compound	Transmission,microscopy
R4725	T7781	T7780	compound	electron,microscopy
R4726	T7783	T7784	nmod	Littermate,pups
R4727	T7784	T7791	nsubjpass	pups,perfused
R4728	T7785	T7784	nmod	Crx,pups
R4729	T7786	T7785	punct	-,Crx
R473	T1096	T1090	punct	", ",diseases
R4730	T7787	T7785	punct	/,Crx
R4731	T7788	T7785	punct	-,Crx
R4732	T7789	T7785	cc	and,Crx
R4733	T7790	T7785	conj	wildtype,Crx
R4734	T7792	T7791	auxpass	were,perfused
R4735	T7793	T7791	prep	in,perfused
R4736	T7794	T7795	nummod	1,%
R4737	T7795	T7796	compound	%,formaldehyde
R4738	T7796	T7793	pobj	formaldehyde,in
R4739	T7797	T7796	cc	and,formaldehyde
R474	T1097	T1090	prep	including,diseases
R4740	T7798	T7799	nummod	0.5,%
R4741	T7799	T7800	compound	%,glutaraldehyde
R4742	T7800	T7796	conj	glutaraldehyde,formaldehyde
R4743	T7801	T7791	prep	at,perfused
R4744	T7802	T7803	amod	various,stages
R4745	T7803	T7801	pobj	stages,at
R4746	T7804	T7803	amod	postnatal,stages
R4747	T7805	T7791	punct	.,perfused
R4748	T7807	T7808	det	The,eyes
R4749	T7808	T7809	nsubjpass	eyes,enucleated
R475	T1098	T1099	compound	cone,rod
R4750	T7810	T7809	auxpass	were,enucleated
R4751	T7811	T7809	advmod	then,enucleated
R4752	T7812	T7809	punct	", ",enucleated
R4753	T7813	T7809	cc	and,enucleated
R4754	T7814	T7815	det	the,cornea
R4755	T7815	T7816	nsubjpass	cornea,removed
R4756	T7816	T7809	conj	removed,enucleated
R4757	T7817	T7815	cc	and,cornea
R4758	T7818	T7815	conj	lens,cornea
R4759	T7819	T7816	auxpass	were,removed
R476	T1099	T1101	compound	rod,dystrophy
R4760	T7820	T7816	punct	.,removed
R4761	T7822	T7823	det	The,cup
R4762	T7823	T7825	nsubjpass	cup,immersed
R4763	T7824	T7823	compound	eye,cup
R4764	T7826	T7825	auxpass	was,immersed
R4765	T7827	T7825	prep	in,immersed
R4766	T7828	T7827	pobj	fixative,in
R4767	T7829	T7828	punct	(,fixative
R4768	T7830	T7831	nummod	1,%
R4769	T7831	T7832	compound	%,formaldehyde
R477	T1100	T1099	punct	-,rod
R4770	T7832	T7828	appos	formaldehyde,fixative
R4771	T7833	T7832	cc	and,formaldehyde
R4772	T7834	T7835	nummod	2.5,%
R4773	T7835	T7836	compound	%,glutaraldehyde
R4774	T7836	T7832	conj	glutaraldehyde,formaldehyde
R4775	T7837	T7828	punct	),fixative
R4776	T7838	T7825	prep	for,immersed
R4777	T7839	T7840	quantmod	3,4
R4778	T7840	T7842	nummod	4,hours
R4779	T7841	T7840	quantmod	to,4
R478	T1101	T1097	pobj	dystrophy,including
R4780	T7842	T7838	pobj	hours,for
R4781	T7843	T7825	prep	at,immersed
R4782	T7844	T7845	nummod	4,°C
R4783	T7845	T7843	pobj	°C,at
R4784	T7846	T7825	punct	.,immersed
R4785	T7848	T7849	det	The,sclera
R4786	T7849	T7850	nsubjpass	sclera,removed
R4787	T7851	T7850	auxpass	was,removed
R4788	T7852	T7850	advmod	then,removed
R4789	T7853	T7850	advmod	partially,removed
R479	T1102	T1101	nummod	2,dystrophy
R4790	T7854	T7850	cc	and,removed
R4791	T7855	T7856	det	the,retinas
R4792	T7856	T7857	nsubjpass	retinas,sliced
R4793	T7857	T7850	conj	sliced,removed
R4794	T7858	T7857	auxpass	were,sliced
R4795	T7859	T7857	prep	into,sliced
R4796	T7860	T7861	amod	small,pieces
R4797	T7861	T7859	pobj	pieces,into
R4798	T7862	T7857	cc	and,sliced
R4799	T7863	T7857	conj	fixed,sliced
R48	T169	T170	nsubjpass	Mutations,found
R480	T1103	T1104	punct	[,14
R4800	T7864	T7865	punct	(,paraformaldehyde
R4801	T7865	T7863	parataxis	paraformaldehyde,fixed
R4802	T7866	T7867	nummod	1,%
R4803	T7867	T7865	compound	%,paraformaldehyde
R4804	T7868	T7865	cc	and,paraformaldehyde
R4805	T7869	T7870	nummod	2.5,%
R4806	T7870	T7871	compound	%,glutaraldehyde
R4807	T7871	T7865	conj	glutaraldehyde,paraformaldehyde
R4808	T7872	T7865	punct	),paraformaldehyde
R4809	T7873	T7863	advmod	overnight,fixed
R481	T1104	T1101	parataxis	14,dystrophy
R4810	T7874	T7863	prep	at,fixed
R4811	T7875	T7876	nummod	4,°C
R4812	T7876	T7874	pobj	°C,at
R4813	T7877	T7857	punct	.,sliced
R4814	T7879	T7880	det	These,procedures
R4815	T7880	T7881	nsubjpass	procedures,found
R4816	T7882	T7881	auxpass	were,found
R4817	T7883	T7881	oprd	optimal,found
R4818	T7884	T7883	prep	for,optimal
R4819	T7885	T7884	pcomp	maintaining,for
R482	T1105	T1104	nummod	6,14
R4820	T7886	T7887	det	the,integrity
R4821	T7887	T7885	dobj	integrity,maintaining
R4822	T7888	T7887	amod	structural,integrity
R4823	T7889	T7887	prep	of,integrity
R4824	T7890	T7891	det	the,segments
R4825	T7891	T7889	pobj	segments,of
R4826	T7892	T7891	nmod	photoreceptor,segments
R4827	T7893	T7891	amod	outer,segments
R4828	T7894	T7881	punct	.,found
R4829	T7896	T7897	prep	After,washed
R483	T1106	T1104	punct	",",14
R4830	T7898	T7896	pobj	fixing,After
R4831	T7899	T7897	punct	", ",washed
R4832	T7900	T7901	det	the,tissue
R4833	T7901	T7897	nsubjpass	tissue,washed
R4834	T7902	T7897	auxpass	was,washed
R4835	T7903	T7897	npadvmod	2,washed
R4836	T7904	T7903	punct	X,2
R4837	T7905	T7897	prep	in,washed
R4838	T7906	T7905	pobj	PBS,in
R4839	T7907	T7897	prep	for,washed
R484	T1107	T1104	nummod	13,14
R4840	T7908	T7909	nummod	thirty,minutes
R4841	T7909	T7907	pobj	minutes,for
R4842	T7910	T7909	prep	per,minutes
R4843	T7911	T7910	pobj	wash,per
R4844	T7912	T7897	punct	.,washed
R4845	T7914	T7915	det	The,tissue
R4846	T7915	T7916	nsubjpass	tissue,postfixed
R4847	T7917	T7916	auxpass	was,postfixed
R4848	T7918	T7916	advmod	then,postfixed
R4849	T7919	T7916	prep	in,postfixed
R485	T1108	T1104	punct	",",14
R4850	T7920	T7921	det	a,mixture
R4851	T7921	T7919	pobj	mixture,in
R4852	T7922	T7923	nummod	1,%
R4853	T7923	T7924	nmod	%,tetroxide
R4854	T7924	T7921	nmod	tetroxide,mixture
R4855	T7925	T7924	nmod	osmium,tetroxide
R4856	T7926	T7924	punct	/,tetroxide
R4857	T7927	T7928	nummod	1.5,%
R4858	T7928	T7929	compound	%,ferrocyanide
R4859	T7929	T7924	appos	ferrocyanide,tetroxide
R486	T1109	T1104	punct	],14
R4860	T7930	T7929	compound	potassium,ferrocyanide
R4861	T7931	T7916	prep	for,postfixed
R4862	T7932	T7933	nummod	2,hours
R4863	T7933	T7931	pobj	hours,for
R4864	T7934	T7916	prep	at,postfixed
R4865	T7935	T7936	nummod	4,°C
R4866	T7936	T7934	pobj	°C,at
R4867	T7937	T7916	punct	.,postfixed
R4868	T7939	T7940	nsubjpass	Staining,carried
R4869	T7941	T7940	auxpass	was,carried
R487	T1110	T1101	punct	", ",dystrophy
R4870	T7942	T7940	prt	out,carried
R4871	T7943	T7940	prep	for,carried
R4872	T7944	T7945	nummod	30,minutes
R4873	T7945	T7943	pobj	minutes,for
R4874	T7946	T7940	prep	in,carried
R4875	T7947	T7948	nummod	1,%
R4876	T7948	T7949	compound	%,acetate
R4877	T7949	T7946	pobj	acetate,in
R4878	T7950	T7949	compound	uranyl,acetate
R4879	T7951	T7940	prep	in,carried
R488	T1111	T1112	compound	retinitis,pigmentosa
R4880	T7952	T7953	compound	maleate,buffer
R4881	T7953	T7951	pobj	buffer,in
R4882	T7954	T7955	punct	(,6.0
R4883	T7955	T7953	parataxis	6.0,buffer
R4884	T7956	T7955	nsubj	pH,6.0
R4885	T7957	T7955	punct	=,6.0
R4886	T7958	T7955	punct	),6.0
R4887	T7959	T7953	prep	at,buffer
R4888	T7960	T7961	compound	room,temperature
R4889	T7961	T7959	pobj	temperature,at
R489	T1112	T1101	conj	pigmentosa,dystrophy
R4890	T7962	T7953	acl	followed,buffer
R4891	T7963	T7962	agent	by,followed
R4892	T7964	T7965	nummod	1,%
R4893	T7965	T7966	nmod	%,acid
R4894	T7966	T7963	pobj	acid,by
R4895	T7967	T7966	amod	tannic,acid
R4896	T7968	T7966	prep	in,acid
R4897	T7969	T7970	nummod	0.1,M
R4898	T7970	T7971	compound	M,buffer
R4899	T7971	T7968	pobj	buffer,in
R49	T171	T169	prep	in,Mutations
R490	T1113	T1114	punct	[,14
R4900	T7972	T7971	compound	cacodylate,buffer
R4901	T7973	T7974	punct	(,7.4
R4902	T7974	T7966	parataxis	7.4,acid
R4903	T7975	T7974	nsubj	pH,7.4
R4904	T7976	T7974	punct	=,7.4
R4905	T7977	T7974	punct	),7.4
R4906	T7978	T7966	prep	for,acid
R4907	T7979	T7980	nummod	thirty,minutes
R4908	T7980	T7978	pobj	minutes,for
R4909	T7981	T7940	punct	.,carried
R491	T1114	T1112	parataxis	14,pigmentosa
R4910	T7983	T7984	det	The,specimens
R4911	T7984	T7985	nsubjpass	specimens,dehydrated
R4912	T7986	T7985	auxpass	were,dehydrated
R4913	T7987	T7985	advmod	then,dehydrated
R4914	T7988	T7985	cc	and,dehydrated
R4915	T7989	T7985	conj	embedded,dehydrated
R4916	T7990	T7989	prep	in,embedded
R4917	T7991	T7992	compound	Epon,Araldite
R4918	T7992	T7990	pobj	Araldite,in
R4919	T7993	T7992	punct	/,Araldite
R492	T1115	T1114	punct	],14
R4920	T7994	T7985	punct	.,dehydrated
R4921	T7996	T7997	amod	Thin,sections
R4922	T7997	T7998	nsubjpass	sections,stained
R4923	T7999	T7998	auxpass	were,stained
R4924	T8000	T7998	prep	with,stained
R4925	T8001	T8002	compound	uranyl,acetate
R4926	T8002	T8000	pobj	acetate,with
R4927	T8003	T8002	cc	and,acetate
R4928	T8004	T8005	compound	lead,citrate
R4929	T8005	T8002	conj	citrate,acetate
R493	T1116	T1112	punct	", ",pigmentosa
R4930	T8006	T7998	punct	", ",stained
R4931	T8007	T7998	cc	and,stained
R4932	T8008	T7998	conj	examined,stained
R4933	T8009	T8008	prep	in,examined
R4934	T8010	T8011	det	a,microscope
R4935	T8011	T8009	pobj	microscope,in
R4936	T8012	T8013	compound	Jeol,1200EX
R4937	T8013	T8011	compound	1200EX,microscope
R4938	T8014	T8013	compound	JEM,1200EX
R4939	T8015	T8013	punct	-,1200EX
R494	T1117	T1112	cc	and,pigmentosa
R4940	T8016	T8011	compound	electron,microscope
R4941	T8017	T7998	punct	.,stained
R4942	T8072	T8073	amod	Scanning,microscopy
R4943	T8074	T8073	compound	electron,microscopy
R4944	T8076	T8077	nsubj	Specimens,required
R4945	T8078	T8076	acl	used,Specimens
R4946	T8079	T8078	prep	for,used
R4947	T8080	T8079	pobj	SEM,for
R4948	T8081	T8077	dobj	removal,required
R4949	T8082	T8081	prep	of,removal
R495	T1118	T1112	conj	LCA,pigmentosa
R4950	T8083	T8084	det	the,epithelium
R4951	T8084	T8082	pobj	epithelium,of
R4952	T8085	T8084	amod	retinal,epithelium
R4953	T8086	T8084	compound	pigment,epithelium
R4954	T8087	T8084	punct	(,epithelium
R4955	T8088	T8084	appos	PE,epithelium
R4956	T8089	T8077	punct	),required
R4957	T8090	T8077	punct	", ",required
R4958	T8091	T8077	advcl	enabling,required
R4959	T8092	T8091	dobj	visualization,enabling
R496	T1119	T1120	punct	[,14
R4960	T8093	T8092	prep	of,visualization
R4961	T8094	T8095	det	the,surface
R4962	T8095	T8093	pobj	surface,of
R4963	T8096	T8095	amod	outer,surface
R4964	T8097	T8095	prep	of,surface
R4965	T8098	T8099	det	the,retina
R4966	T8099	T8097	pobj	retina,of
R4967	T8100	T8099	amod	neural,retina
R4968	T8101	T8077	punct	.,required
R4969	T8103	T8104	nsubjpass	Retinae,dissected
R497	T1120	T1118	parataxis	14,LCA
R4970	T8105	T8103	prep	from,Retinae
R4971	T8106	T8107	nmod	Crx,eyes
R4972	T8107	T8105	pobj	eyes,from
R4973	T8108	T8106	punct	-,Crx
R4974	T8109	T8106	punct	/,Crx
R4975	T8110	T8106	punct	-,Crx
R4976	T8111	T8106	punct	", ",Crx
R4977	T8112	T8106	conj	rhodopsin,Crx
R4978	T8113	T8112	punct	-,rhodopsin
R4979	T8114	T8112	punct	/,rhodopsin
R498	T1121	T1122	punct	-,16
R4980	T8115	T8112	punct	-,rhodopsin
R4981	T8116	T8112	punct	", ",rhodopsin
R4982	T8117	T8112	conj	RDS,rhodopsin
R4983	T8118	T8117	punct	", ",RDS
R4984	T8119	T8117	cc	or,RDS
R4985	T8120	T8117	conj	wildtype,RDS
R4986	T8121	T8104	auxpass	were,dissected
R4987	T8122	T8104	oprd	free,dissected
R4988	T8123	T8122	prep	from,free
R4989	T8124	T8123	pobj	PE,from
R499	T1122	T1120	prep	16,14
R4990	T8125	T8104	prep	in,dissected
R4991	T8126	T8127	det	a,solution
R4992	T8127	T8125	pobj	solution,in
R4993	T8128	T8127	compound	dispase,solution
R4994	T8129	T8104	cc	and,dissected
R4995	T8130	T8104	conj	fixed,dissected
R4996	T8131	T8130	prep	in,fixed
R4997	T8132	T8133	nummod	1.25,%
R4998	T8133	T8134	compound	%,glutaraldehyde
R4999	T8134	T8131	pobj	glutaraldehyde,in
R5	T118	T115	cc	and,Synaptogenesis
R50	T172	T171	pobj	genes,in
R500	T1123	T1120	punct	],14
R5000	T8135	T8134	cc	and,glutaraldehyde
R5001	T8136	T8137	nummod	1.0,%
R5002	T8137	T8138	compound	%,formaldehyde
R5003	T8138	T8134	conj	formaldehyde,glutaraldehyde
R5004	T8139	T8130	advmod	overnight,fixed
R5005	T8140	T8130	prep	at,fixed
R5006	T8141	T8142	nummod	4,°C
R5007	T8142	T8140	pobj	°C,at
R5008	T8143	T8104	punct	.,dissected
R5009	T8145	T8146	nsubjpass	Tissue,washed
R501	T1124	T1083	punct	.,associated
R5010	T8147	T8146	auxpass	was,washed
R5011	T8148	T8146	advmod	then,washed
R5012	T8149	T8146	npadvmod	5,washed
R5013	T8150	T8149	punct	X,5
R5014	T8151	T8146	prep	in,washed
R5015	T8152	T8153	compound	cacodylate,buffer
R5016	T8153	T8151	pobj	buffer,in
R5017	T8154	T8146	cc	and,washed
R5018	T8155	T8146	conj	dehydrated,washed
R5019	T8156	T8155	prep	in,dehydrated
R502	T1126	T1127	prep	Based,hypothesized
R5020	T8157	T8158	amod	ascending,grades
R5021	T8158	T8156	pobj	grades,in
R5022	T8159	T8158	prep	of,grades
R5023	T8160	T8159	pobj	ethanol,of
R5024	T8161	T8146	punct	.,washed
R5025	T8163	T8164	nsubjpass	Tissues,dried
R5026	T8165	T8164	auxpass	were,dried
R5027	T8166	T8164	advmod	subsequently,dried
R5028	T8167	T8168	amod	critical,point
R5029	T8168	T8164	npadvmod	point,dried
R503	T1128	T1126	prep	on,Based
R5030	T8169	T8164	prep	in,dried
R5031	T8170	T8171	compound	carbon,dioxide
R5032	T8171	T8169	pobj	dioxide,in
R5033	T8172	T8164	punct	.,dried
R5034	T8174	T8175	det	All,specimens
R5035	T8175	T8176	nsubjpass	specimens,mounted
R5036	T8177	T8176	auxpass	were,mounted
R5037	T8178	T8176	cc	and,mounted
R5038	T8179	T8176	conj	coated,mounted
R5039	T8180	T8179	prep	with,coated
R504	T1129	T1130	det	these,data
R5040	T8181	T8182	amod	sublimated,palladium
R5041	T8182	T8180	pobj	palladium,with
R5042	T8183	T8182	compound	gold,palladium
R5043	T8184	T8182	punct	-,palladium
R5044	T8185	T8179	prep	by,coated
R5045	T8186	T8187	det	the,technique
R5046	T8187	T8185	pobj	technique,by
R5047	T8188	T8187	compound	sputtering,technique
R5048	T8189	T8176	punct	.,mounted
R5049	T8191	T8192	nsubjpass	Micrographs,obtained
R505	T1130	T1128	pobj	data,on
R5050	T8193	T8192	auxpass	were,obtained
R5051	T8194	T8192	prep	with,obtained
R5052	T8195	T8196	det	a,microscope
R5053	T8196	T8194	pobj	microscope,with
R5054	T8197	T8198	nmod	Jeol,35CF
R5055	T8198	T8196	nmod	35CF,microscope
R5056	T8199	T8198	nmod	JSM,35CF
R5057	T8200	T8198	punct	-,35CF
R5058	T8201	T8196	amod	scanning,microscope
R5059	T8202	T8196	compound	electron,microscope
R506	T1131	T1127	punct	", ",hypothesized
R5060	T8203	T8192	punct	.,obtained
R5061	T8250	T8251	compound	Transmission,microscopy
R5062	T8252	T8251	compound	electron,microscopy
R5063	T8253	T8251	prep	of,microscopy
R5064	T8254	T8255	det	the,retina
R5065	T8255	T8253	pobj	retina,of
R5066	T8256	T8255	amod	outer,retina
R5067	T8257	T8251	prep	at,microscopy
R5068	T8258	T8257	pobj	P21,at
R5069	T8259	T8251	prep	in,microscopy
R507	T1132	T1127	nsubjpass	Crx,hypothesized
R5070	T8260	T8261	punct	(,A
R5071	T8261	T8262	meta	A,Crx
R5072	T8262	T8264	nmod	Crx,retinas
R5073	T8263	T8261	punct	),A
R5074	T8264	T8259	pobj	retinas,in
R5075	T8265	T8262	punct	+,Crx
R5076	T8266	T8262	punct	/,Crx
R5077	T8267	T8262	punct	+,Crx
R5078	T8268	T8262	cc	and,Crx
R5079	T8269	T8270	punct	(,B
R508	T1133	T1127	auxpass	was,hypothesized
R5080	T8270	T8271	meta	B,Crx
R5081	T8271	T8262	conj	Crx,Crx
R5082	T8272	T8270	punct	),B
R5083	T8273	T8271	punct	-,Crx
R5084	T8274	T8271	punct	/,Crx
R5085	T8275	T8271	punct	-,Crx
R5086	T8276	T8251	punct	.,microscopy
R5087	T8279	T8278	punct	", ",pe
R5088	T8280	T8281	amod	pigmented,epithelium
R5089	T8281	T8278	appos	epithelium,pe
R509	T1134	T1135	aux	to,play
R5090	T8282	T8278	punct	.,pe
R5091	T8285	T8284	punct	", ",os
R5092	T8286	T8287	amod	outer,segments
R5093	T8287	T8284	appos	segments,os
R5094	T8288	T8284	punct	.,os
R5095	T8291	T8290	punct	", ",is
R5096	T8292	T8293	amod	inner,segments
R5097	T8293	T8290	appos	segments,is
R5098	T8294	T8290	punct	.,is
R5099	T8297	T8296	punct	", ",onl
R51	T173	T174	dep	that,affect
R510	T1135	T1127	xcomp	play,hypothesized
R5100	T8298	T8299	amod	outer,layer
R5101	T8299	T8296	appos	layer,onl
R5102	T8300	T8299	amod	nuclear,layer
R5103	T8301	T8299	prep	with,layer
R5104	T8302	T8303	compound	photoreceptor,nuclei
R5105	T8303	T8301	pobj	nuclei,with
R5106	T8304	T8296	punct	.,onl
R5107	T8306	T8307	compound	Scale,bar
R5108	T8307	T8308	nsubj	bar,μm
R5109	T8309	T8308	punct	=,μm
R511	T1136	T1137	det	a,role
R5110	T8310	T8308	nummod	5,μm
R5111	T8311	T8308	prep	for,μm
R5112	T8312	T8311	pobj	A,for
R5113	T8313	T8312	cc	and,A
R5114	T8314	T8312	conj	B,A
R5115	T8315	T8308	punct	.,μm
R5118	T8372	T8373	compound	Transmission,micrograph
R5119	T8374	T8373	compound	electron,micrograph
R512	T1137	T1135	dobj	role,play
R5120	T8375	T8373	prep	of,micrograph
R5121	T8376	T8377	det	the,layer
R5122	T8377	T8375	pobj	layer,of
R5123	T8378	T8379	amod	outer,segment
R5124	T8379	T8377	compound	segment,layer
R5125	T8380	T8377	prep	of,layer
R5126	T8381	T8382	nmod	Crx,retina
R5127	T8382	T8380	pobj	retina,of
R5128	T8383	T8381	punct	-,Crx
R5129	T8384	T8381	punct	/,Crx
R513	T1138	T1137	amod	critical,role
R5130	T8385	T8381	punct	-,Crx
R5131	T8386	T8373	prep	at,micrograph
R5132	T8387	T8386	pobj	P21,at
R5133	T8388	T8373	punct	.,micrograph
R5134	T8390	T8391	amod	Inner,segments
R5135	T8391	T8392	nsubj	segments,exhibit
R5136	T8393	T8391	prep	of,segments
R5137	T8394	T8395	nmod	Crx,photoreceptors
R5138	T8395	T8393	pobj	photoreceptors,of
R5139	T8396	T8394	punct	-,Crx
R514	T1139	T1135	prep	in,play
R5140	T8397	T8394	punct	/,Crx
R5141	T8398	T8394	punct	-,Crx
R5142	T8399	T8400	amod	numerous,mitochondria
R5143	T8400	T8392	dobj	mitochondria,exhibit
R5144	T8401	T8402	punct	(,indicated
R5145	T8402	T8400	parataxis	indicated,mitochondria
R5146	T8403	T8402	nsubj	m,indicated
R5147	T8404	T8402	agent	by,indicated
R5148	T8405	T8404	pobj	arrow,by
R5149	T8406	T8402	punct	),indicated
R515	T1140	T1141	det	the,differentiation
R5150	T8407	T8392	prep	as,exhibit
R5151	T8408	T8407	prep	in,as
R5152	T8409	T8408	pobj	Crx,in
R5153	T8410	T8409	punct	+,Crx
R5154	T8411	T8409	punct	/,Crx
R5155	T8412	T8409	punct	+,Crx
R5156	T8413	T8414	punct	(,Figure
R5157	T8414	T8392	parataxis	Figure,exhibit
R5158	T8415	T8414	nummod	1A,Figure
R5159	T8416	T8414	punct	),Figure
R516	T1141	T1139	pobj	differentiation,in
R5160	T8417	T8392	punct	.,exhibit
R5161	T8420	T8419	punct	", ",pe
R5162	T8421	T8422	amod	pigmented,epithelium
R5163	T8422	T8419	appos	epithelium,pe
R5164	T8423	T8419	punct	.,pe
R5165	T8426	T8425	punct	", ",is
R5166	T8427	T8428	amod	inner,segments
R5167	T8428	T8425	appos	segments,is
R5168	T8429	T8425	punct	.,is
R5169	T8432	T8431	punct	", ",onl
R517	T1142	T1141	cc	and,differentiation
R5170	T8433	T8434	amod	outer,layer
R5171	T8434	T8431	appos	layer,onl
R5172	T8435	T8434	amod	nuclear,layer
R5173	T8436	T8431	punct	.,onl
R5174	T8438	T8439	compound	Scale,bar
R5175	T8439	T8440	nsubj	bar,μm
R5176	T8441	T8440	punct	=,μm
R5177	T8442	T8440	nummod	2,μm
R5178	T8443	T8440	punct	.,μm
R518	T1143	T1141	conj	maintainance,differentiation
R5181	T8570	T8571	compound	Transmission,micrograph
R5182	T8572	T8571	compound	electron,micrograph
R5183	T8573	T8571	prep	of,micrograph
R5184	T8574	T8575	nmod	Crx,retina
R5185	T8575	T8573	pobj	retina,of
R5186	T8576	T8574	punct	-,Crx
R5187	T8577	T8574	punct	/,Crx
R5188	T8578	T8574	punct	-,Crx
R5189	T8579	T8575	prep	at,retina
R519	T1144	T1141	prep	of,differentiation
R5190	T8580	T8579	pobj	P21,at
R5191	T8581	T8582	punct	(,A
R5192	T8582	T8571	parataxis	A,micrograph
R5193	T8583	T8582	cc	and,A
R5194	T8584	T8582	conj	B,A
R5195	T8585	T8582	punct	),A
R5196	T8586	T8571	punct	", ",micrograph
R5197	T8587	T8571	cc	and,micrograph
R5198	T8588	T8589	amod	scanning,micrograph
R5199	T8589	T8571	conj	micrograph,micrograph
R52	T174	T172	relcl	affect,genes
R520	T1145	T1146	compound	photoreceptor,cells
R5200	T8590	T8589	compound	electron,micrograph
R5201	T8591	T8589	prep	of,micrograph
R5202	T8592	T8591	pobj	Crx,of
R5203	T8593	T8592	punct	-,Crx
R5204	T8594	T8592	punct	/,Crx
R5205	T8595	T8592	punct	-,Crx
R5206	T8596	T8592	prep	at,Crx
R5207	T8597	T8596	pobj	P10,at
R5208	T8598	T8599	punct	(,C
R5209	T8599	T8589	parataxis	C,micrograph
R521	T1146	T1144	pobj	cells,of
R5210	T8600	T8599	punct	),C
R5211	T8601	T8571	prep	of,micrograph
R5212	T8602	T8603	amod	outer,segment
R5213	T8603	T8604	compound	segment,layer
R5214	T8604	T8601	pobj	layer,of
R5215	T8605	T8571	punct	.,micrograph
R5216	T8607	T8608	punct	(,A
R5217	T8608	T8609	meta	A,Evidence
R5218	T8610	T8608	punct	),A
R5219	T8611	T8609	prep	of,Evidence
R522	T1147	T1148	punct	[,7
R5220	T8612	T8611	pobj	ciliogenesis,of
R5221	T8613	T8609	prep	in,Evidence
R5222	T8614	T8615	det	the,layer
R5223	T8615	T8613	pobj	layer,in
R5224	T8616	T8615	compound	photoreceptor,layer
R5225	T8617	T8615	prep	of,layer
R5226	T8618	T8619	nmod	Crx,retina
R5227	T8619	T8617	pobj	retina,of
R5228	T8620	T8618	punct	-,Crx
R5229	T8621	T8618	punct	/,Crx
R523	T1148	T1135	parataxis	7,play
R5230	T8622	T8618	punct	-,Crx
R5231	T8623	T8609	punct	.,Evidence
R5232	T8625	T8626	amod	Nonmotile,cilia
R5233	T8626	T8628	nsubjpass	cilia,observed
R5234	T8627	T8626	amod	connecting,cilia
R5235	T8629	T8628	auxpass	were,observed
R5236	T8630	T8628	prep	in,observed
R5237	T8631	T8632	compound	cross,section
R5238	T8632	T8630	pobj	section,in
R5239	T8633	T8634	punct	(,1
R524	T1149	T1148	nummod	5,7
R5240	T8634	T8628	parataxis	1,observed
R5241	T8635	T8634	nmod	arrowheads,1
R5242	T8636	T8634	punct	",",1
R5243	T8637	T8634	conj	2,1
R5244	T8638	T8637	punct	", ",2
R5245	T8639	T8637	cc	and,2
R5246	T8640	T8637	conj	3,2
R5247	T8641	T8634	punct	", ",1
R5248	T8642	T8634	prep	for,1
R5249	T8643	T8642	pobj	examples,for
R525	T1150	T1148	punct	",",7
R5250	T8644	T8634	punct	),1
R5251	T8645	T8628	punct	.,observed
R5252	T8647	T8648	amod	Connecting,cilium
R5253	T8648	T8649	nsubj	cilium,demonstrated
R5254	T8650	T8648	nummod	1,cilium
R5255	T8651	T8652	punct	(,arrowhead
R5256	T8652	T8648	parataxis	arrowhead,cilium
R5257	T8653	T8652	nummod	1,arrowhead
R5258	T8654	T8652	punct	),arrowhead
R5259	T8655	T8656	nummod	seven,doublets
R526	T1151	T1148	punct	],7
R5260	T8656	T8649	dobj	doublets,demonstrated
R5261	T8657	T8656	amod	microtuble,doublets
R5262	T8658	T8649	punct	", ",demonstrated
R5263	T8659	T8660	mark	while,exhibited
R5264	T8660	T8649	advcl	exhibited,demonstrated
R5265	T8661	T8660	nsubj	cilium,exhibited
R5266	T8662	T8661	nummod	2,cilium
R5267	T8663	T8661	cc	and,cilium
R5268	T8664	T8661	conj	cilium,cilium
R5269	T8665	T8664	nummod	3,cilium
R527	T1152	T1127	punct	.,hypothesized
R5270	T8666	T8660	dobj	nine,exhibited
R5271	T8667	T8649	punct	.,demonstrated
R5272	T8669	T8670	prep	In,seen
R5273	T8671	T8669	pobj	A,In
R5274	T8672	T8670	punct	", ",seen
R5275	T8673	T8674	det	a,nucleus
R5276	T8674	T8670	nsubjpass	nucleus,seen
R5277	T8675	T8674	amod	displaced,nucleus
R5278	T8676	T8674	compound	cell,nucleus
R5279	T8677	T8674	punct	(,nucleus
R528	T1154	T1155	nsubj	LCA,is
R5280	T8678	T8674	appos	n,nucleus
R5281	T8679	T8674	punct	),nucleus
R5282	T8680	T8674	acl	appearing,nucleus
R5283	T8681	T8680	oprd	pyknotic,appearing
R5284	T8682	T8674	cc	and,nucleus
R5285	T8683	T8684	amod	abnormal,deposition
R5286	T8684	T8674	conj	deposition,nucleus
R5287	T8685	T8684	prep	of,deposition
R5288	T8686	T8687	nmod	matrix,material
R5289	T8687	T8685	pobj	material,of
R529	T1156	T1157	det	the,disease
R5290	T8688	T8686	punct	(,matrix
R5291	T8689	T8686	appos	mx,matrix
R5292	T8690	T8687	punct	),material
R5293	T8691	T8687	prep	of,material
R5294	T8692	T8693	amod	unknown,identity
R5295	T8693	T8691	pobj	identity,of
R5296	T8694	T8670	auxpass	were,seen
R5297	T8695	T8670	punct	", ",seen
R5298	T8696	T8670	prep	along,seen
R5299	T8697	T8696	prep	with,along
R53	T175	T176	det	the,development
R530	T1157	T1155	attr	disease,is
R5300	T8698	T8699	amod	large,amounts
R5301	T8699	T8697	pobj	amounts,with
R5302	T8700	T8699	prep	of,amounts
R5303	T8701	T8702	amod	membranous,vesicles
R5304	T8702	T8700	pobj	vesicles,of
R5305	T8703	T8704	punct	(,arrow
R5306	T8704	T8702	parataxis	arrow,vesicles
R5307	T8705	T8704	punct	),arrow
R5308	T8706	T8707	dep	which,filled
R5309	T8707	T8699	relcl	filled,amounts
R531	T1158	T1159	advmod	most,severe
R5310	T8708	T8709	det	the,space
R5311	T8709	T8707	dobj	space,filled
R5312	T8710	T8709	compound	photoreceptor,space
R5313	T8711	T8707	cc	and,filled
R5314	T8712	T8707	conj	appeared,filled
R5315	T8713	T8714	aux	to,released
R5316	T8714	T8712	xcomp	released,appeared
R5317	T8715	T8714	auxpass	be,released
R5318	T8716	T8714	prep	from,released
R5319	T8717	T8718	amod	inner,segments
R532	T1159	T1157	amod	severe,disease
R5320	T8718	T8716	pobj	segments,from
R5321	T8719	T8670	punct	.,seen
R5322	T8721	T8722	compound	Scale,bar
R5323	T8722	T8723	nsubj	bar,μm
R5324	T8724	T8723	punct	=,μm
R5325	T8725	T8723	nummod	3.7,μm
R5326	T8726	T8723	punct	.,μm
R5327	T8728	T8729	punct	(,B
R5328	T8729	T8730	meta	B,cilium
R5329	T8731	T8729	punct	),B
R533	T1160	T1157	amod	genetic,disease
R5330	T8732	T8730	amod	Nonmotile,cilium
R5331	T8733	T8730	amod	connecting,cilium
R5332	T8734	T8730	prep	in,cilium
R5333	T8735	T8736	compound	cross,section
R5334	T8736	T8734	pobj	section,in
R5335	T8737	T8730	punct	", ",cilium
R5336	T8738	T8730	prep	from,cilium
R5337	T8739	T8740	det	a,photoreceptor
R5338	T8740	T8738	pobj	photoreceptor,from
R5339	T8741	T8740	nmod	Crx,photoreceptor
R534	T1161	T1157	prep	of,disease
R5340	T8742	T8741	punct	-,Crx
R5341	T8743	T8741	punct	/,Crx
R5342	T8744	T8741	punct	-,Crx
R5343	T8745	T8730	punct	", ",cilium
R5344	T8746	T8730	acl	demonstrating,cilium
R5345	T8747	T8748	amod	characteristic,array
R5346	T8748	T8746	dobj	array,demonstrating
R5347	T8749	T8750	nummod	9,0
R5348	T8750	T8748	nummod	0,array
R5349	T8751	T8750	punct	+,0
R535	T1162	T1161	pobj	photoreceptors,of
R5350	T8752	T8748	amod	radial,array
R5351	T8753	T8748	prep	of,array
R5352	T8754	T8755	compound	microtubule,doublets
R5353	T8755	T8753	pobj	doublets,of
R5354	T8756	T8730	punct	.,cilium
R5355	T8758	T8759	compound	Scale,bar
R5356	T8759	T8760	nsubj	bar,nm
R5357	T8761	T8760	punct	=,nm
R5358	T8762	T8760	nummod	88,nm
R5359	T8763	T8760	punct	.,nm
R536	T1163	T1164	punct	(,see
R5360	T8765	T8766	punct	(,C
R5361	T8766	T8767	meta	C,micrograph
R5362	T8768	T8766	punct	),C
R5363	T8769	T8767	amod	Scanning,micrograph
R5364	T8770	T8767	compound	electron,micrograph
R5365	T8771	T8772	punct	(,SEM
R5366	T8772	T8767	appos	SEM,micrograph
R5367	T8773	T8767	punct	),micrograph
R5368	T8774	T8767	prep	of,micrograph
R5369	T8775	T8776	amod	membranous,vesicles
R537	T1164	T1155	parataxis	see,is
R5370	T8776	T8774	pobj	vesicles,of
R5371	T8777	T8778	punct	(,shows
R5372	T8778	T8776	parataxis	shows,vesicles
R5373	T8779	T8778	nsubj	arrow,shows
R5374	T8780	T8781	nummod	one,example
R5375	T8781	T8778	dobj	example,shows
R5376	T8782	T8778	punct	),shows
R5377	T8783	T8776	acl	shed,vesicles
R5378	T8784	T8783	prep	from,shed
R5379	T8785	T8786	amod	inner,segments
R538	T1165	T1164	punct	[,see
R5380	T8786	T8784	pobj	segments,from
R5381	T8787	T8786	prep	of,segments
R5382	T8788	T8789	nmod	Crx,photoreceptors
R5383	T8789	T8787	pobj	photoreceptors,of
R5384	T8790	T8788	punct	-,Crx
R5385	T8791	T8788	punct	/,Crx
R5386	T8792	T8788	punct	-,Crx
R5387	T8793	T8783	prep	at,shed
R5388	T8794	T8793	pobj	P10,at
R5389	T8795	T8767	punct	.,micrograph
R539	T1166	T1164	dobj	17,see
R5390	T8797	T8798	nsubj	Figure,shows
R5391	T8799	T8800	amod	inner,segments
R5392	T8800	T8798	dobj	segments,shows
R5393	T8801	T8800	acl	viewed,segments
R5394	T8802	T8801	prep	from,viewed
R5395	T8803	T8804	det	the,side
R5396	T8804	T8802	pobj	side,from
R5397	T8805	T8804	amod	scleral,side
R5398	T8806	T8807	mark	with,removed
R5399	T8807	T8798	advcl	removed,shows
R54	T176	T174	dobj	development,affect
R540	T1167	T1164	punct	],see
R5400	T8808	T8809	det	the,epithelium
R5401	T8809	T8807	nsubj	epithelium,removed
R5402	T8810	T8809	amod	pigmented,epithelium
R5403	T8811	T8798	punct	.,shows
R5404	T8813	T8814	compound	Scale,bar
R5405	T8814	T8815	nsubj	bar,μm
R5406	T8816	T8815	punct	=,μm
R5407	T8817	T8815	nummod	1,μm
R5408	T8818	T8815	punct	.,μm
R5409	T8923	T8924	compound	Outer,segment
R541	T1168	T1164	punct	", ",see
R5410	T8924	T8925	compound	segment,morphogenesis
R5411	T8926	T8925	prep	in,morphogenesis
R5412	T8927	T8928	nmod	Crx,photoreceptors
R5413	T8928	T8926	pobj	photoreceptors,in
R5414	T8929	T8927	punct	-,Crx
R5415	T8930	T8927	punct	/,Crx
R5416	T8931	T8927	punct	-,Crx
R5417	T8932	T8925	punct	.,morphogenesis
R5418	T8934	T8935	amod	Scanning,microscopy
R5419	T8936	T8935	compound	electron,microscopy
R542	T1169	T1164	prep	for,see
R5420	T8937	T8935	prep	of,microscopy
R5421	T8938	T8939	amod	developing,photoreceptors
R5422	T8939	T8937	pobj	photoreceptors,of
R5423	T8940	T8939	acl	viewed,photoreceptors
R5424	T8941	T8940	prep	from,viewed
R5425	T8942	T8943	det	the,side
R5426	T8943	T8941	pobj	side,from
R5427	T8944	T8943	amod	scleral,side
R5428	T8945	T8946	mark	with,removed
R5429	T8946	T8940	advcl	removed,viewed
R543	T1170	T1171	amod	recent,review
R5430	T8947	T8948	det	the,epithelium
R5431	T8948	T8946	nsubj	epithelium,removed
R5432	T8949	T8948	amod	pigmented,epithelium
R5433	T8950	T8946	prep	at,removed
R5434	T8951	T8950	pobj	P7,at
R5435	T8952	T8951	punct	", ",P7
R5436	T8953	T8951	conj	P14,P7
R5437	T8954	T8953	punct	", ",P14
R5438	T8955	T8953	cc	and,P14
R5439	T8956	T8953	conj	P21,P14
R544	T1171	T1169	pobj	review,for
R5440	T8957	T8946	prep	for,removed
R5441	T8958	T8959	nmod	Crx,littermates
R5442	T8959	T8957	pobj	littermates,for
R5443	T8960	T8958	punct	+,Crx
R5444	T8961	T8958	punct	/,Crx
R5445	T8962	T8958	punct	+,Crx
R5446	T8963	T8964	punct	(,A
R5447	T8964	T8958	parataxis	A,Crx
R5448	T8965	T8964	punct	", ",A
R5449	T8966	T8964	conj	C,A
R545	T1172	T1164	punct	),see
R5450	T8967	T8966	punct	", ",C
R5451	T8968	T8966	cc	and,C
R5452	T8969	T8966	conj	E,C
R5453	T8970	T8964	punct	),A
R5454	T8971	T8958	cc	and,Crx
R5455	T8972	T8958	conj	Crx,Crx
R5456	T8973	T8972	punct	-,Crx
R5457	T8974	T8972	punct	/,Crx
R5458	T8975	T8972	punct	-,Crx
R5459	T8976	T8977	punct	(,F
R546	T1173	T1155	punct	.,is
R5460	T8977	T8972	parataxis	F,Crx
R5461	T8978	T8977	nmod	B,F
R5462	T8979	T8977	punct	", ",F
R5463	T8980	T8977	nmod	D,F
R5464	T8981	T8977	punct	", ",F
R5465	T8982	T8977	punct	),F
R5466	T8983	T8935	punct	.,microscopy
R5467	T8985	T8986	prep	In,were
R5468	T8987	T8988	nmod	Crx,retina
R5469	T8988	T8985	pobj	retina,In
R547	T1175	T1176	amod	Affected,infants
R5470	T8989	T8987	punct	+,Crx
R5471	T8990	T8987	punct	/,Crx
R5472	T8991	T8987	punct	+,Crx
R5473	T8992	T8986	punct	", ",were
R5474	T8993	T8994	amod	numerous,cilia
R5475	T8994	T8986	nsubj	cilia,were
R5476	T8995	T8994	amod	connecting,cilia
R5477	T8996	T8997	punct	(,cc
R5478	T8997	T8994	parataxis	cc,cilia
R5479	T8998	T8997	dep	A,cc
R548	T1176	T1177	nsubj	infants,exhibit
R5480	T8999	T8997	punct	", ",cc
R5481	T9000	T8997	punct	),cc
R5482	T9001	T8986	acomp	evident,were
R5483	T9002	T8986	prep	at,were
R5484	T9003	T9002	pobj	P7,at
R5485	T9004	T8986	prep	with,were
R5486	T9005	T9006	amod	rudimentary,segments
R5487	T9006	T9004	pobj	segments,with
R5488	T9007	T9006	amod	outer,segments
R5489	T9008	T8986	punct	.,were
R549	T1178	T1179	det	a,absence
R5490	T9010	T9011	prep	After,occurs
R5491	T9012	T9010	pobj	P7,After
R5492	T9013	T9011	punct	", ",occurs
R5493	T9014	T9011	prep	in,occurs
R5494	T9015	T9014	pobj	Crx,in
R5495	T9016	T9015	punct	+,Crx
R5496	T9017	T9015	punct	/,Crx
R5497	T9018	T9015	punct	+,Crx
R5498	T9019	T9020	amod	outer,segment
R5499	T9020	T9021	compound	segment,elongation
R55	T177	T176	cc	and,development
R550	T1179	T1177	dobj	absence,exhibit
R5500	T9021	T9011	nsubj	elongation,occurs
R5501	T9022	T9011	punct	.,occurs
R5502	T9024	T9025	advmod	Initially,have
R5503	T9026	T9025	punct	", ",have
R5504	T9027	T9028	amod	outer,segments
R5505	T9028	T9025	nsubj	segments,have
R5506	T9029	T9030	det	a,structure
R5507	T9030	T9025	dobj	structure,have
R5508	T9031	T9032	npadvmod	paddle,like
R5509	T9032	T9030	amod	like,structure
R551	T1180	T1179	amod	complete,absence
R5510	T9033	T9032	punct	-,like
R5511	T9034	T9035	punct	(,os
R5512	T9035	T9030	parataxis	os,structure
R5513	T9036	T9035	dep	C,os
R5514	T9037	T9035	punct	", ",os
R5515	T9038	T9035	punct	),os
R5516	T9039	T9040	dep	which,shed
R5517	T9040	T9030	relcl	shed,structure
R5518	T9041	T9040	auxpass	is,shed
R5519	T9042	T9040	advmod	later,shed
R552	T1181	T1180	cc	or,complete
R5520	T9043	T9044	punct	(,os
R5521	T9044	T9040	parataxis	os,shed
R5522	T9045	T9044	dep	E,os
R5523	T9046	T9044	punct	", ",os
R5524	T9047	T9044	punct	),os
R5525	T9048	T9025	punct	.,have
R5526	T9050	T9051	prep	In,observed
R5527	T9052	T9053	nmod	Crx,photoreceptors
R5528	T9053	T9050	pobj	photoreceptors,In
R5529	T9054	T9052	punct	-,Crx
R553	T1182	T1183	advmod	near,complete
R5530	T9055	T9052	punct	/,Crx
R5531	T9056	T9052	punct	-,Crx
R5532	T9057	T9051	punct	", ",observed
R5533	T9058	T9059	amod	few,cilia
R5534	T9059	T9051	nsubjpass	cilia,observed
R5535	T9060	T9059	amod	connecting,cilia
R5536	T9061	T9051	auxpass	were,observed
R5537	T9062	T9051	prep	at,observed
R5538	T9063	T9062	pobj	P7,at
R5539	T9064	T9065	punct	(,cc
R554	T1183	T1180	conj	complete,complete
R5540	T9065	T9051	parataxis	cc,observed
R5541	T9066	T9065	dep	B,cc
R5542	T9067	T9065	punct	", ",cc
R5543	T9068	T9065	punct	),cc
R5544	T9069	T9051	punct	.,observed
R5545	T9071	T9072	prep	After,were
R5546	T9073	T9071	pobj	P7,After
R5547	T9074	T9072	punct	", ",were
R5548	T9075	T9076	amod	connecting,cilia
R5549	T9076	T9072	nsubj	cilia,were
R555	T1184	T1179	prep	of,absence
R5550	T9077	T9078	advmod	more,numerous
R5551	T9078	T9072	acomp	numerous,were
R5552	T9079	T9072	cc	and,were
R5553	T9080	T9081	advmod	occasionally,noted
R5554	T9081	T9072	conj	noted,were
R5555	T9082	T9083	det	a,segment
R5556	T9083	T9081	nsubjpass	segment,noted
R5557	T9084	T9083	amod	malformed,segment
R5558	T9085	T9083	amod	outer,segment
R5559	T9086	T9081	auxpass	was,noted
R556	T1185	T1184	pobj	vision,of
R5560	T9087	T9081	advcl	extending,noted
R5561	T9088	T9087	prep	from,extending
R5562	T9089	T9090	det	a,cilium
R5563	T9090	T9088	pobj	cilium,from
R5564	T9091	T9090	amod	connecting,cilium
R5565	T9092	T9093	punct	(,cc*
R5566	T9093	T9081	parataxis	cc*,noted
R5567	T9094	T9093	dep	D,cc*
R5568	T9095	T9094	cc	and,D
R5569	T9096	T9094	conj	F,D
R557	T1186	T1177	prep	from,exhibit
R5570	T9097	T9093	punct	", ",cc*
R5571	T9098	T9093	punct	),cc*
R5572	T9099	T9081	punct	.,noted
R5573	T9101	T9102	nsubjpass	These,observed
R5574	T9103	T9102	auxpass	were,observed
R5575	T9104	T9102	advmod	rarely,observed
R5576	T9105	T9102	prep	in,observed
R5577	T9106	T9105	pobj	Crx,in
R5578	T9107	T9106	punct	+,Crx
R5579	T9108	T9106	punct	/,Crx
R558	T1187	T1186	pobj	birth,from
R5580	T9109	T9106	punct	+,Crx
R5581	T9110	T9102	cc	and,observed
R5582	T9111	T9112	advmod	only,at
R5583	T9112	T9110	prep	at,and
R5584	T9113	T9112	pobj	P14,at
R5585	T9114	T9115	punct	(,cc*
R5586	T9115	T9102	parataxis	cc*,observed
R5587	T9116	T9115	dep	C,cc*
R5588	T9117	T9115	punct	", ",cc*
R5589	T9118	T9115	punct	),cc*
R559	T1188	T1177	punct	.,exhibit
R5590	T9119	T9102	punct	.,observed
R5591	T9121	T9122	prep	At,noted
R5592	T9123	T9121	pobj	P21,At
R5593	T9124	T9122	punct	", ",noted
R5594	T9125	T9126	advmod	abnormally,long
R5595	T9126	T9127	amod	long,cilia
R5596	T9127	T9122	nsubjpass	cilia,noted
R5597	T9128	T9127	amod	connecting,cilia
R5598	T9129	T9122	auxpass	are,noted
R5599	T9130	T9122	prep	in,noted
R56	T178	T177	punct	/,and
R560	T1190	T1191	nsubjpass	Mutations,associated
R5600	T9131	T9130	pobj	Crx,in
R5601	T9132	T9131	punct	-,Crx
R5602	T9133	T9131	punct	/,Crx
R5603	T9134	T9131	punct	-,Crx
R5604	T9135	T9136	punct	(,cc
R5605	T9136	T9122	parataxis	cc,noted
R5606	T9137	T9136	dep	F,cc
R5607	T9138	T9136	punct	", ",cc
R5608	T9139	T9136	punct	),cc
R5609	T9140	T9122	punct	.,noted
R561	T1192	T1190	prep	in,Mutations
R5610	T9142	T9143	compound	Scale,bars
R5611	T9143	T9144	nsubj	bars,μm
R5612	T9145	T9144	punct	=,μm
R5613	T9146	T9144	nummod	10,μm
R5616	T9204	T9205	compound	Transmission,micrographs
R5617	T9206	T9205	compound	electron,micrographs
R5618	T9207	T9205	prep	of,micrographs
R5619	T9208	T9209	nmod	Crx,photoreceptors
R562	T1193	T1194	npadvmod	retinal,specific
R5620	T9209	T9207	pobj	photoreceptors,of
R5621	T9210	T9208	punct	-,Crx
R5622	T9211	T9208	punct	/,Crx
R5623	T9212	T9208	punct	-,Crx
R5624	T9213	T9205	prep	in,micrographs
R5625	T9214	T9215	det	the,layer
R5626	T9215	T9213	pobj	layer,in
R5627	T9216	T9215	compound	photoreceptor,layer
R5628	T9217	T9205	prep	at,micrographs
R5629	T9218	T9217	pobj	P7,at
R563	T1194	T1195	amod	specific,genes
R5630	T9219	T9205	punct	.,micrographs
R5631	T9221	T9222	punct	(,A
R5632	T9222	T9223	meta	A,layer
R5633	T9224	T9222	punct	),A
R5634	T9225	T9223	compound	Photoreceptor,layer
R5635	T9226	T9223	prep	of,layer
R5636	T9227	T9228	nmod	Crx,retina
R5637	T9228	T9226	pobj	retina,of
R5638	T9229	T9227	punct	+,Crx
R5639	T9230	T9227	punct	/,Crx
R564	T1195	T1192	pobj	genes,in
R5640	T9231	T9227	punct	+,Crx
R5641	T9232	T9223	acl	demonstrating,layer
R5642	T9233	T9234	amod	nascent,structures
R5643	T9234	T9237	nsubj	structures,emerging
R5644	T9235	T9236	amod	outer,segment
R5645	T9236	T9234	compound	segment,structures
R5646	T9237	T9232	ccomp	emerging,demonstrating
R5647	T9238	T9239	punct	(,arrow
R5648	T9239	T9237	parataxis	arrow,emerging
R5649	T9240	T9239	punct	),arrow
R565	T1196	T1195	punct	", ",genes
R5650	T9241	T9237	prep	from,emerging
R5651	T9242	T9243	nmod	photoreceptor,cilia
R5652	T9243	T9241	pobj	cilia,from
R5653	T9244	T9243	amod	connecting,cilia
R5654	T9245	T9243	punct	(,cilia
R5655	T9246	T9243	appos	cc,cilia
R5656	T9247	T9243	punct	),cilia
R5657	T9248	T9223	punct	.,layer
R5658	T9250	T9251	punct	(,B
R5659	T9251	T9252	meta	B,observed
R566	T1197	T1198	amod	such,as
R5660	T9253	T9251	punct	),B
R5661	T9254	T9255	nmod	Crx,photoreceptors
R5662	T9255	T9259	nsubj	photoreceptors,exhibited
R5663	T9256	T9254	punct	-,Crx
R5664	T9257	T9254	punct	/,Crx
R5665	T9258	T9254	punct	-,Crx
R5666	T9259	T9252	ccomp	exhibited,observed
R5667	T9260	T9261	amod	connecting,cilia
R5668	T9261	T9259	dobj	cilia,exhibited
R5669	T9262	T9261	punct	(,cilia
R567	T1198	T1195	prep	as,genes
R5670	T9263	T9261	appos	cc,cilia
R5671	T9264	T9259	punct	),exhibited
R5672	T9265	T9259	prep	at,exhibited
R5673	T9266	T9267	det	this,stage
R5674	T9267	T9265	pobj	stage,at
R5675	T9268	T9267	amod	early,stage
R5676	T9269	T9252	punct	", ",observed
R5677	T9270	T9252	advmod	however,observed
R5678	T9271	T9252	punct	", ",observed
R5679	T9272	T9273	amod	nascent,structures
R568	T1199	T1198	pobj	Crx,as
R5680	T9273	T9252	nsubjpass	structures,observed
R5681	T9274	T9275	amod	outer,segment
R5682	T9275	T9273	compound	segment,structures
R5683	T9276	T9252	auxpass	were,observed
R5684	T9277	T9252	neg	not,observed
R5685	T9278	T9252	punct	.,observed
R5686	T9280	T9281	compound	Scale,Bar
R5687	T9281	T9282	nsubj	Bar,μm
R5688	T9283	T9282	punct	=,μm
R5689	T9284	T9282	nummod	1,μm
R569	T1200	T1191	punct	", ",associated
R5690	T9285	T9282	punct	.,μm
R5691	T9319	T9320	amod	Scanning,microscopy
R5692	T9321	T9320	compound	electron,microscopy
R5693	T9322	T9320	prep	of,microscopy
R5694	T9323	T9324	nmod	peripherin,photoreceptors
R5695	T9324	T9322	pobj	photoreceptors,of
R5696	T9325	T9323	punct	-,peripherin
R5697	T9326	T9323	punct	/,peripherin
R5698	T9327	T9323	punct	-,peripherin
R5699	T9328	T9329	punct	(,A
R57	T179	T177	cc	or,and
R570	T1201	T1191	aux	have,associated
R5700	T9329	T9323	parataxis	A,peripherin
R5701	T9330	T9329	punct	),A
R5702	T9331	T9323	cc	and,peripherin
R5703	T9332	T9323	conj	rhodopsin,peripherin
R5704	T9333	T9332	punct	-,rhodopsin
R5705	T9334	T9332	punct	/,rhodopsin
R5706	T9335	T9332	punct	-,rhodopsin
R5707	T9336	T9337	punct	(,B
R5708	T9337	T9332	parataxis	B,rhodopsin
R5709	T9338	T9337	punct	),B
R571	T1202	T1191	auxpass	been,associated
R5710	T9339	T9320	prep	at,microscopy
R5711	T9340	T9339	pobj	P21,at
R5712	T9341	T9320	punct	", ",microscopy
R5713	T9342	T9320	acl	viewed,microscopy
R5714	T9343	T9342	prep	from,viewed
R5715	T9344	T9345	det	the,side
R5716	T9345	T9343	pobj	side,from
R5717	T9346	T9345	amod	scleral,side
R5718	T9347	T9348	mark	with,removed
R5719	T9348	T9342	advcl	removed,viewed
R572	T1203	T1191	prep	with,associated
R5720	T9349	T9350	det	the,epithelium
R5721	T9350	T9348	nsubj	epithelium,removed
R5722	T9351	T9350	amod	pigmented,epithelium
R5723	T9352	T9320	punct	.,microscopy
R5724	T9355	T9354	punct	", ",cc
R5725	T9356	T9357	amod	connecting,cilium
R5726	T9357	T9354	appos	cilium,cc
R5727	T9358	T9354	punct	.,cc
R5728	T9361	T9360	punct	", ",is
R5729	T9362	T9363	amod	inner,segment
R573	T1204	T1203	pobj	LCA,with
R5730	T9363	T9360	appos	segment,is
R5731	T9364	T9360	punct	.,is
R5732	T9366	T9367	compound	Scale,bar
R5733	T9367	T9368	nsubj	bar,μm
R5734	T9369	T9368	punct	=,μm
R5735	T9370	T9368	nummod	10,μm
R5736	T9371	T9368	punct	.,μm
R574	T1205	T1206	punct	[,15
R5743	T9460	T9461	compound	Transmission,micrographs
R5744	T9462	T9461	compound	electron,micrographs
R5745	T9463	T9461	prep	of,micrographs
R5746	T9464	T9465	det	the,layer
R5747	T9465	T9463	pobj	layer,of
R5748	T9466	T9467	amod	outer,plexiform
R5749	T9467	T9465	compound	plexiform,layer
R575	T1206	T1204	parataxis	15,LCA
R5750	T9468	T9461	prep	in,micrographs
R5751	T9469	T9470	nmod	Crx,retinas
R5752	T9470	T9468	pobj	retinas,in
R5753	T9471	T9469	punct	-,Crx
R5754	T9472	T9469	punct	/,Crx
R5755	T9473	T9469	punct	-,Crx
R5756	T9474	T9461	punct	.,micrographs
R5757	T9476	T9477	punct	(,A
R5758	T9477	T9478	meta	A,were
R5759	T9479	T9477	punct	),A
R576	T1207	T1206	nummod	14,15
R5760	T9480	T9478	prep	In,were
R5761	T9481	T9482	nmod	Crx,retina
R5762	T9482	T9480	pobj	retina,In
R5763	T9483	T9481	punct	+,Crx
R5764	T9484	T9481	punct	/,Crx
R5765	T9485	T9481	punct	+,Crx
R5766	T9486	T9478	prep	at,were
R5767	T9487	T9486	pobj	P21,at
R5768	T9488	T9478	punct	", ",were
R5769	T9489	T9490	advmod	newly,formed
R577	T1208	T1206	punct	",",15
R5770	T9490	T9491	amod	formed,spherules
R5771	T9491	T9478	nsubj	spherules,were
R5772	T9492	T9491	compound	rod,spherules
R5773	T9493	T9478	acomp	abundant,were
R5774	T9494	T9495	punct	(,demonstrates
R5775	T9495	T9478	parataxis	demonstrates,were
R5776	T9496	T9495	nsubj	arrow,demonstrates
R5777	T9497	T9498	nummod	one,example
R5778	T9498	T9495	dobj	example,demonstrates
R5779	T9499	T9495	punct	),demonstrates
R578	T1209	T1206	punct	],15
R5780	T9500	T9478	punct	.,were
R5781	T9502	T9503	det	The,spherules
R5782	T9503	T9504	nsubj	spherules,were
R5783	T9505	T9506	npadvmod	club,shaped
R5784	T9506	T9504	acomp	shaped,were
R5785	T9507	T9506	punct	-,shaped
R5786	T9508	T9504	cc	and,were
R5787	T9509	T9504	conj	contained,were
R5788	T9510	T9511	det	a,synapse
R5789	T9511	T9509	dobj	synapse,contained
R579	T1210	T1204	punct	", ",LCA
R5790	T9512	T9511	amod	single,synapse
R5791	T9513	T9511	amod	invaginating,synapse
R5792	T9514	T9511	prep	with,synapse
R5793	T9515	T9516	nummod	one,complex
R5794	T9516	T9514	pobj	complex,with
R5795	T9517	T9516	compound	ribbon,complex
R5796	T9518	T9504	punct	.,were
R5797	T9520	T9521	compound	Cone,terminals
R5798	T9521	T9522	nsubj	terminals,form
R5799	T9523	T9524	amod	large,pedicles
R58	T180	T176	conj	function,development
R580	T1211	T1212	advmod	as,as
R5800	T9524	T9522	dobj	pedicles,form
R5801	T9525	T9524	punct	", ",pedicles
R5802	T9526	T9524	amod	flat,pedicles
R5803	T9527	T9528	dep	that,contain
R5804	T9528	T9524	relcl	contain,pedicles
R5805	T9529	T9530	amod	many,synapses
R5806	T9530	T9528	dobj	synapses,contain
R5807	T9531	T9530	amod	invaginating,synapses
R5808	T9532	T9530	prep	with,synapses
R5809	T9533	T9534	amod	separate,structures
R581	T1212	T1204	cc	as,LCA
R5810	T9534	T9532	pobj	structures,with
R5811	T9535	T9534	compound	ribbon,structures
R5812	T9536	T9522	punct	.,form
R5813	T9538	T9539	det	These,terminals
R5814	T9539	T9540	nsubj	terminals,were
R5815	T9541	T9542	advmod	more,scarce
R5816	T9542	T9540	acomp	scarce,were
R5817	T9543	T9542	punct	", ",scarce
R5818	T9544	T9542	cc	but,scarce
R5819	T9545	T9542	conj	apparent,scarce
R582	T1213	T1212	advmod	well,as
R5820	T9546	T9540	prep	in,were
R5821	T9547	T9548	nmod	Crx,retinas
R5822	T9548	T9546	pobj	retinas,in
R5823	T9549	T9547	punct	+,Crx
R5824	T9550	T9547	punct	/,Crx
R5825	T9551	T9547	punct	+,Crx
R5826	T9552	T9540	prep	at,were
R5827	T9553	T9552	pobj	P21,at
R5828	T9554	T9555	punct	(,example
R5829	T9555	T9553	parataxis	example,P21
R583	T1214	T1204	conj	GUCY2D,LCA
R5830	T9556	T9555	nummod	one,example
R5831	T9557	T9555	prep	in,example
R5832	T9558	T9557	pobj	box,in
R5833	T9559	T9555	punct	),example
R5834	T9560	T9540	punct	.,were
R5835	T9562	T9563	punct	(,B
R5836	T9563	T9564	meta	B,appeared
R5837	T9565	T9563	punct	),B
R5838	T9566	T9564	prep	In,appeared
R5839	T9567	T9568	det	the,layer
R584	T1215	T1216	punct	[,18
R5840	T9568	T9566	pobj	layer,In
R5841	T9569	T9568	amod	outer,layer
R5842	T9570	T9568	compound	plexiform,layer
R5843	T9571	T9568	punct	(,layer
R5844	T9572	T9568	appos	OPL,layer
R5845	T9573	T9568	punct	),layer
R5846	T9574	T9568	prep	of,layer
R5847	T9575	T9576	nmod	Crx,retinas
R5848	T9576	T9574	pobj	retinas,of
R5849	T9577	T9575	punct	-,Crx
R585	T1216	T1214	parataxis	18,GUCY2D
R5850	T9578	T9575	punct	/,Crx
R5851	T9579	T9575	punct	-,Crx
R5852	T9580	T9564	punct	", ",appeared
R5853	T9581	T9582	compound	photoreceptor,terminals
R5854	T9582	T9564	nsubj	terminals,appeared
R5855	T9583	T9584	advmod	highly,disorganized
R5856	T9584	T9564	oprd	disorganized,appeared
R5857	T9585	T9564	prep	at,appeared
R5858	T9586	T9585	pobj	P21,at
R5859	T9587	T9588	punct	(,arrows
R586	T1217	T1216	punct	],18
R5860	T9588	T9564	parataxis	arrows,appeared
R5861	T9589	T9588	punct	),arrows
R5862	T9590	T9564	punct	.,appeared
R5863	T9592	T9593	advmod	Well,formed
R5864	T9593	T9595	amod	formed,pedicles
R5865	T9594	T9593	punct	-,formed
R5866	T9595	T9596	nsubj	pedicles,were
R5867	T9597	T9595	cc	and,pedicles
R5868	T9598	T9595	conj	spherules,pedicles
R5869	T9599	T9596	neg	not,were
R587	T1218	T1214	punct	", ",GUCY2D
R5870	T9600	T9596	acomp	evident,were
R5871	T9601	T9596	punct	.,were
R5872	T9603	T9604	amod	Putative,terminals
R5873	T9604	T9605	nsubj	terminals,were
R5874	T9606	T9604	acl	containing,terminals
R5875	T9607	T9608	npadvmod	ribbon,like
R5876	T9608	T9610	amod	like,structures
R5877	T9609	T9608	punct	-,like
R5878	T9610	T9606	dobj	structures,containing
R5879	T9611	T9605	acomp	apparent,were
R588	T1219	T1214	conj	RPE65,GUCY2D
R5880	T9612	T9605	punct	", ",were
R5881	T9613	T9605	advcl	suggesting,were
R5882	T9614	T9615	advmod	at,least
R5883	T9615	T9616	advmod	least,limited
R5884	T9616	T9617	amod	limited,generation
R5885	T9617	T9613	dobj	generation,suggesting
R5886	T9618	T9617	prep	of,generation
R5887	T9619	T9620	compound	synapse,components
R5888	T9620	T9618	pobj	components,of
R5889	T9621	T9605	punct	.,were
R589	T1220	T1221	punct	[,19
R5890	T9623	T9624	amod	Many,terminals
R5891	T9624	T9625	nsubj	terminals,appeared
R5892	T9626	T9627	aux	to,contain
R5893	T9627	T9625	xcomp	contain,appeared
R5894	T9628	T9629	amod	multiple,structures
R5895	T9629	T9627	dobj	structures,contain
R5896	T9630	T9631	npadvmod	ribbon,like
R5897	T9631	T9629	amod	like,structures
R5898	T9632	T9631	punct	-,like
R5899	T9633	T9629	punct	", ",structures
R59	T181	T176	prep	of,development
R590	T1221	T1219	parataxis	19,RPE65
R5900	T9634	T9635	advmod	instead,of
R5901	T9635	T9629	prep	of,structures
R5902	T9636	T9637	det	a,ribbon
R5903	T9637	T9635	pobj	ribbon,of
R5904	T9638	T9637	amod	singule,ribbon
R5905	T9639	T9625	punct	.,appeared
R5906	T9641	T9642	prep	For,contained
R5907	T9643	T9641	pobj	example,For
R5908	T9644	T9642	punct	", ",contained
R5909	T9645	T9646	nmod	terminal,1
R591	T1222	T1221	punct	],19
R5910	T9646	T9642	nsubj	1,contained
R5911	T9647	T9646	cc	and,1
R5912	T9648	T9646	conj	2,1
R5913	T9649	T9650	nummod	two,ribbons
R5914	T9650	T9642	dobj	ribbons,contained
R5915	T9651	T9650	appos	each,ribbons
R5916	T9652	T9642	punct	", ",contained
R5917	T9653	T9654	mark	whereas,appeared
R5918	T9654	T9642	advcl	appeared,contained
R5919	T9655	T9654	nsubj	terminal,appeared
R592	T1223	T1219	punct	", ",RPE65
R5920	T9656	T9655	nummod	3,terminal
R5921	T9657	T9658	aux	to,contain
R5922	T9658	T9654	xcomp	contain,appeared
R5923	T9659	T9660	advmod	only,one
R5924	T9660	T9658	dobj	one,contain
R5925	T9661	T9642	punct	.,contained
R5926	T9664	T9663	punct	", ",opl
R5927	T9665	T9666	amod	outer,layer
R5928	T9666	T9663	appos	layer,opl
R5929	T9667	T9666	compound	plexiform,layer
R593	T1224	T1219	conj	AIPL,RPE65
R5930	T9668	T9663	punct	.,opl
R5931	T9670	T9671	compound	Scale,bar
R5932	T9671	T9672	nsubj	bar,μm
R5933	T9673	T9672	punct	=,μm
R5934	T9674	T9672	nummod	2,μm
R5935	T9675	T9672	punct	.,μm
R5938	T9811	T9812	compound	Transmission,micrographs
R5939	T9813	T9812	compound	electron,micrographs
R594	T1225	T1224	punct	-,AIPL
R5940	T9814	T9812	prep	of,micrographs
R5941	T9815	T9816	det	the,layer
R5942	T9816	T9814	pobj	layer,of
R5943	T9817	T9818	amod	outer,plexiform
R5944	T9818	T9816	compound	plexiform,layer
R5945	T9819	T9812	prep	in,micrographs
R5946	T9820	T9821	nmod	Crx,retinas
R5947	T9821	T9819	pobj	retinas,in
R5948	T9822	T9820	punct	-,Crx
R5949	T9823	T9820	punct	/,Crx
R595	T1226	T1224	nummod	1,AIPL
R5950	T9824	T9820	punct	-,Crx
R5951	T9825	T9812	prep	at,micrographs
R5952	T9826	T9825	pobj	P21,at
R5953	T9827	T9812	punct	.,micrographs
R5954	T9829	T9830	punct	(,A
R5955	T9830	T9831	meta	A,contained
R5956	T9832	T9830	punct	),A
R5957	T9833	T9834	nmod	Crx,spherules
R5958	T9834	T9831	nsubj	spherules,contained
R5959	T9835	T9833	punct	+,Crx
R596	T1227	T1228	punct	[,20
R5960	T9836	T9833	punct	/,Crx
R5961	T9837	T9833	punct	+,Crx
R5962	T9838	T9834	compound	rod,spherules
R5963	T9839	T9840	det	a,synapse
R5964	T9840	T9831	dobj	synapse,contained
R5965	T9841	T9840	amod	single,synapse
R5966	T9842	T9840	amod	invaginating,synapse
R5967	T9843	T9840	prep	with,synapse
R5968	T9844	T9845	nummod	one,complex
R5969	T9845	T9843	pobj	complex,with
R597	T1228	T1224	parataxis	20,AIPL
R5970	T9846	T9845	compound	ribbon,complex
R5971	T9847	T9831	punct	.,contained
R5972	T9849	T9850	det	The,spherule
R5973	T9850	T9851	nsubj	spherule,was
R5974	T9852	T9853	det	a,structure
R5975	T9853	T9851	attr	structure,was
R5976	T9854	T9853	amod	blunt,structure
R5977	T9855	T9854	cc	or,blunt
R5978	T9856	T9857	npadvmod	club,shaped
R5979	T9857	T9854	conj	shaped,blunt
R598	T1229	T1228	punct	],20
R5980	T9858	T9857	punct	-,shaped
R5981	T9859	T9851	punct	.,was
R5982	T9861	T9862	punct	(,B
R5983	T9862	T9863	meta	B,contained
R5984	T9864	T9862	punct	),B
R5985	T9865	T9866	nmod	Crx,terminals
R5986	T9866	T9863	nsubj	terminals,contained
R5987	T9867	T9865	punct	+,Crx
R5988	T9868	T9865	punct	/,Crx
R5989	T9869	T9865	punct	+,Crx
R599	T1230	T1224	punct	", ",AIPL
R5990	T9870	T9866	compound	rod,terminals
R5991	T9871	T9872	det	a,structure
R5992	T9872	T9863	dobj	structure,contained
R5993	T9873	T9872	amod	single,structure
R5994	T9874	T9872	compound	ribbon,structure
R5995	T9875	T9872	punct	(,structure
R5996	T9876	T9872	appos	r,structure
R5997	T9877	T9863	punct	),contained
R5998	T9878	T9863	punct	.,contained
R5999	T9880	T9881	nummod	Two,processes
R6	T119	T120	amod	outer,segment
R60	T182	T183	compound	photoreceptor,cells
R600	T1231	T1224	conj	CRB,AIPL
R6000	T9881	T9882	nsubj	processes,contacted
R6001	T9883	T9881	punct	", ",processes
R6002	T9884	T9881	prep	from,processes
R6003	T9885	T9886	amod	horizontal,cells
R6004	T9886	T9884	pobj	cells,from
R6005	T9887	T9886	punct	(,cells
R6006	T9888	T9886	appos	h,cells
R6007	T9889	T9882	punct	),contacted
R6008	T9890	T9882	punct	", ",contacted
R6009	T9891	T9892	det	the,rod
R601	T1232	T1231	punct	-,CRB
R6010	T9892	T9882	dobj	rod,contacted
R6011	T9893	T9882	advmod	laterally,contacted
R6012	T9894	T9882	punct	.,contacted
R6013	T9896	T9897	det	An,process
R6014	T9897	T9899	nsubjpass	process,situated
R6015	T9898	T9897	amod	additional,process
R6016	T9900	T9897	punct	", ",process
R6017	T9901	T9902	det	the,dendrite
R6018	T9902	T9897	appos	dendrite,process
R6019	T9903	T9902	amod	postsynaptic,dendrite
R602	T1233	T1231	nummod	1,CRB
R6020	T9904	T9902	amod	bipolar,dendrite
R6021	T9905	T9902	punct	(,dendrite
R6022	T9906	T9902	appos	b,dendrite
R6023	T9907	T9899	punct	),situated
R6024	T9908	T9899	punct	", ",situated
R6025	T9909	T9899	auxpass	was,situated
R6026	T9910	T9911	advmod	more,centrally
R6027	T9911	T9899	advmod	centrally,situated
R6028	T9912	T9899	punct	.,situated
R6029	T9914	T9915	nsubjpass	Terminals,filled
R603	T1234	T1235	punct	[,21
R6030	T9916	T9915	auxpass	were,filled
R6031	T9917	T9915	prep	with,filled
R6032	T9918	T9919	amod	synaptic,vesicles
R6033	T9919	T9917	pobj	vesicles,with
R6034	T9920	T9915	punct	.,filled
R6035	T9922	T9923	nummod	One,vesicle
R6036	T9923	T9925	nsubjpass	vesicle,observed
R6037	T9924	T9923	amod	coated,vesicle
R6038	T9926	T9923	acl	originatinf,vesicle
R6039	T9927	T9926	prep	from,originatinf
R604	T1235	T1231	parataxis	21,CRB
R6040	T9928	T9929	det	the,membrane
R6041	T9929	T9927	pobj	membrane,from
R6042	T9930	T9929	compound	cell,membrane
R6043	T9931	T9925	auxpass	was,observed
R6044	T9932	T9933	punct	(,arrow
R6045	T9933	T9925	parataxis	arrow,observed
R6046	T9934	T9933	punct	),arrow
R6047	T9935	T9925	punct	.,observed
R6048	T9937	T9938	punct	(,C
R6049	T9938	T9939	meta	C,appeared
R605	T1236	T1235	punct	],21
R6050	T9940	T9938	punct	),C
R6051	T9941	T9939	prep	In,appeared
R6052	T9942	T9943	det	the,OPL
R6053	T9943	T9941	pobj	OPL,In
R6054	T9944	T9943	prep	of,OPL
R6055	T9945	T9946	nmod	Crx,retinas
R6056	T9946	T9944	pobj	retinas,of
R6057	T9947	T9945	punct	-,Crx
R6058	T9948	T9945	punct	/,Crx
R6059	T9949	T9945	punct	-,Crx
R606	T1237	T1231	punct	", ",CRB
R6060	T9950	T9939	punct	", ",appeared
R6061	T9951	T9952	compound	photoreceptor,terminals
R6062	T9952	T9939	nsubj	terminals,appeared
R6063	T9953	T9954	advmod	highly,disorganized
R6064	T9954	T9939	oprd	disorganized,appeared
R6065	T9955	T9939	punct	.,appeared
R6066	T9957	T9958	amod	Putative,terminals
R6067	T9958	T9959	nsubj	terminals,were
R6068	T9960	T9958	acl	containing,terminals
R6069	T9961	T9962	amod	synaptic,vesicles
R607	T1238	T1231	cc	and,CRB
R6070	T9962	T9960	dobj	vesicles,containing
R6071	T9963	T9962	cc	and,vesicles
R6072	T9964	T9965	npadvmod	ribbon,like
R6073	T9965	T9967	amod	like,structures
R6074	T9966	T9965	punct	-,like
R6075	T9967	T9962	conj	structures,vesicles
R6076	T9968	T9959	acomp	apparent,were
R6077	T9969	T9970	punct	(,arrows
R6078	T9970	T9959	parataxis	arrows,were
R6079	T9971	T9970	punct	),arrows
R608	T1239	T1231	conj	RPGRIP,CRB
R6080	T9972	T9959	punct	", ",were
R6081	T9973	T9959	advcl	suggesting,were
R6082	T9974	T9975	advmod	at,least
R6083	T9975	T9976	advmod	least,limited
R6084	T9976	T9977	amod	limited,generation
R6085	T9977	T9973	dobj	generation,suggesting
R6086	T9978	T9977	prep	of,generation
R6087	T9979	T9980	compound	synapse,components
R6088	T9980	T9978	pobj	components,of
R6089	T9981	T9959	punct	.,were
R609	T1240	T1239	punct	-,RPGRIP
R6090	T9983	T9984	advmod	However,observed
R6091	T9985	T9984	punct	", ",observed
R6092	T9986	T9987	advmod	well,formed
R6093	T9987	T9988	amod	formed,spherules
R6094	T9988	T9984	nsubjpass	spherules,observed
R6095	T9989	T9988	cc	and,spherules
R6096	T9990	T9988	conj	pedicles,spherules
R6097	T9991	T9984	auxpass	were,observed
R6098	T9992	T9984	neg	not,observed
R6099	T9993	T9984	punct	.,observed
R61	T183	T181	pobj	cells,of
R610	T1241	T1239	nummod	1,RPGRIP
R6100	T9995	T9996	advmod	Further,appeared
R6101	T9997	T9996	punct	", ",appeared
R6102	T9998	T9999	amod	many,terminals
R6103	T9999	T9996	nsubj	terminals,appeared
R6104	T10000	T10001	aux	to,contain
R6105	T10001	T9996	xcomp	contain,appeared
R6106	T10002	T10003	amod	multiple,structures
R6107	T10003	T10001	dobj	structures,contain
R6108	T10004	T10005	npadvmod	ribbon,like
R6109	T10005	T10003	amod	like,structures
R611	T1242	T1243	punct	[,22
R6110	T10006	T10005	punct	-,like
R6111	T10007	T10003	punct	(,structures
R6112	T10008	T10003	appos	r,structures
R6113	T10009	T9996	punct	),appeared
R6114	T10010	T9996	punct	.,appeared
R6115	T10012	T10013	det	The,majority
R6116	T10013	T10014	nsubjpass	majority,associated
R6117	T10015	T10013	prep	of,majority
R6118	T10016	T10017	det	these,ribbons
R6119	T10017	T10015	pobj	ribbons,of
R612	T1243	T1239	parataxis	22,RPGRIP
R6120	T10018	T10014	auxpass	were,associated
R6121	T10019	T10014	neg	not,associated
R6122	T10020	T10014	prep	with,associated
R6123	T10021	T10022	det	the,membrane
R6124	T10022	T10020	pobj	membrane,with
R6125	T10023	T10022	amod	synaptic,membrane
R6126	T10024	T10014	punct	", ",associated
R6127	T10025	T10014	cc	but,associated
R6128	T10026	T10025	advmod	instead,but
R6129	T10027	T10028	auxpass	were,found
R613	T1244	T1243	punct	],22
R6130	T10028	T10014	conj	found,associated
R6131	T10029	T10030	amod	free,floating
R6132	T10030	T10028	advcl	floating,found
R6133	T10031	T10028	cc	and,found
R6134	T10032	T10028	punct	", ",found
R6135	T10033	T10034	prep	in,were
R6136	T10034	T10028	conj	were,found
R6137	T10035	T10036	det	some,instances
R6138	T10036	T10033	pobj	instances,in
R6139	T10037	T10034	punct	", ",were
R614	T1245	T1191	punct	.,associated
R6140	T10038	T10034	acomp	perinuclear,were
R6141	T10039	T10040	punct	(,arrow
R6142	T10040	T10034	parataxis	arrow,were
R6143	T10041	T10040	dep	D,arrow
R6144	T10042	T10040	punct	", ",arrow
R6145	T10043	T10040	punct	),arrow
R6146	T10044	T10014	punct	.,associated
R6147	T10047	T10046	punct	", ",H
R6148	T10048	T10049	amod	horizontal,cell
R6149	T10049	T10046	appos	cell,H
R615	T1247	T1248	expl	There,be
R6150	T10050	T10046	punct	;,H
R6151	T10051	T10046	appos	B,H
R6152	T10052	T10051	punct	", ",B
R6153	T10053	T10054	amod	bipolar,cell
R6154	T10054	T10051	appos	cell,B
R6155	T10055	T10046	punct	;,H
R6156	T10056	T10046	appos	N,H
R6157	T10057	T10056	punct	", ",N
R6158	T10058	T10056	appos	nucleus,N
R6159	T10059	T10046	punct	;,H
R616	T1249	T1248	advmod	also,be
R6160	T10060	T10046	appos	r,H
R6161	T10061	T10060	punct	", ",r
R6162	T10062	T10060	appos	ribbon,r
R6163	T10063	T10046	punct	.,H
R6164	T10065	T10066	punct	(,A
R6165	T10066	T10067	meta	A,nm
R6166	T10067	T10073	ccomp	nm,nm
R6167	T10068	T10066	punct	),A
R6168	T10069	T10070	compound	Scale,bar
R6169	T10070	T10067	nsubj	bar,nm
R617	T1250	T1248	aux	may,be
R6170	T10071	T10067	punct	=,nm
R6171	T10072	T10067	nummod	500,nm
R6172	T10074	T10073	punct	", ",nm
R6173	T10075	T10076	punct	(,B
R6174	T10076	T10077	meta	B,nm
R6175	T10077	T10073	ccomp	nm,nm
R6176	T10078	T10076	punct	),B
R6177	T10079	T10080	compound	Scale,bar
R6178	T10080	T10077	nsubj	bar,nm
R6179	T10081	T10077	punct	=,nm
R618	T1251	T1252	advmod	as,three
R6180	T10082	T10077	nummod	250,nm
R6181	T10083	T10073	punct	", ",nm
R6182	T10084	T10085	punct	(,C
R6183	T10085	T10073	meta	C,nm
R6184	T10086	T10085	cc	and,C
R6185	T10087	T10085	conj	D,C
R6186	T10088	T10087	punct	),D
R6187	T10089	T10090	compound	Scale,bar
R6188	T10090	T10073	nsubj	bar,nm
R6189	T10091	T10073	punct	=,nm
R619	T1252	T1255	nummod	three,loci
R6190	T10092	T10073	nummod	500,nm
R6191	T10093	T10073	punct	.,nm
R62	T184	T170	aux	have,found
R620	T1253	T1252	amod	many,three
R621	T1254	T1252	quantmod	as,three
R622	T1255	T1248	attr	loci,be
R623	T1256	T1255	amod	additional,loci
R624	T1257	T1258	advmod	genetically,linked
R625	T1258	T1255	amod	linked,loci
R626	T1259	T1260	advmod	where,identified
R627	T1260	T1255	relcl	identified,loci
R628	T1261	T1260	nsubjpass	genes,identified
R629	T1262	T1260	aux	have,identified
R63	T185	T170	auxpass	been,found
R630	T1263	T1260	neg	not,identified
R631	T1264	T1260	auxpass	been,identified
R632	T1265	T1266	punct	[,23
R633	T1266	T1255	parataxis	23,loci
R634	T1267	T1266	punct	],23
R635	T1268	T1248	punct	.,be
R636	T1270	T1271	compound	Crx,mutations
R637	T1271	T1272	nsubj	mutations,are
R638	T1273	T1271	prep	in,mutations
R639	T1274	T1273	pobj	LCA,in
R64	T186	T187	aux	to,be
R640	T1275	T1272	acomp	varied,are
R641	T1276	T1272	punct	", ",are
R642	T1277	T1272	cc	and,are
R643	T1278	T1272	conj	include,are
R644	T1279	T1280	det	a,mutation
R645	T1280	T1278	dobj	mutation,include
R646	T1281	T1280	amod	putative,mutation
R647	T1282	T1280	amod	dominant,mutation
R648	T1283	T1284	dep	that,proposed
R649	T1284	T1280	relcl	proposed,mutation
R65	T187	T170	xcomp	be,found
R650	T1285	T1284	auxpass	is,proposed
R651	T1286	T1287	aux	to,encode
R652	T1287	T1284	xcomp	encode,proposed
R653	T1288	T1289	det	a,form
R654	T1289	T1287	dobj	form,encode
R655	T1290	T1291	amod	dominant,negative
R656	T1291	T1289	nmod	negative,form
R657	T1292	T1291	punct	-,negative
R658	T1293	T1289	prep	of,form
R659	T1294	T1293	pobj	Crx,of
R66	T188	T187	acomp	responsible,be
R660	T1295	T1296	punct	[,15
R661	T1296	T1287	parataxis	15,encode
R662	T1297	T1296	nummod	14,15
R663	T1298	T1296	punct	",",15
R664	T1299	T1296	punct	],15
R665	T1300	T1272	punct	.,are
R666	T1302	T1303	amod	Recessive,mutations
R667	T1303	T1304	nsubjpass	mutations,reported
R668	T1305	T1304	advmod	also,reported
R669	T1306	T1304	aux	have,reported
R67	T189	T170	prep	in,found
R670	T1307	T1304	auxpass	been,reported
R671	T1308	T1304	cc	and,reported
R672	T1309	T1310	advmod	at,one
R673	T1310	T1312	nummod	one,allele
R674	T1311	T1310	advmod	least,one
R675	T1312	T1313	nsubj	allele,encodes
R676	T1313	T1304	conj	encodes,reported
R677	T1314	T1315	det	a,protein
R678	T1315	T1313	dobj	protein,encodes
R679	T1316	T1315	prep	with,protein
R68	T190	T191	det	some,families
R680	T1317	T1318	amod	decreased,activity
R681	T1318	T1316	pobj	activity,with
R682	T1319	T1318	nmod	DNA,activity
R683	T1320	T1319	punct	-,DNA
R684	T1321	T1319	amod	binding,DNA
R685	T1322	T1323	punct	[,16
R686	T1323	T1313	parataxis	16,encodes
R687	T1324	T1323	punct	],16
R688	T1325	T1313	punct	.,encodes
R689	T1327	T1328	amod	Histopathological,studies
R69	T191	T189	pobj	families,in
R690	T1328	T1331	nsubj	studies,enable
R691	T1329	T1327	cc	and,Histopathological
R692	T1330	T1327	conj	ultrastructural,Histopathological
R693	T1332	T1328	prep	of,studies
R694	T1333	T1332	pobj	LCA,of
R695	T1334	T1331	aux	should,enable
R696	T1335	T1336	det	a,understanding
R697	T1336	T1331	dobj	understanding,enable
R698	T1337	T1336	amod	better,understanding
R699	T1338	T1336	prep	of,understanding
R7	T120	T121	compound	segment,formation
R70	T192	T170	punct	.,found
R700	T1339	T1340	det	the,process
R701	T1340	T1338	pobj	process,of
R702	T1341	T1340	compound	disease,process
R703	T1342	T1336	punct	", ",understanding
R704	T1343	T1336	cc	and,understanding
R705	T1344	T1345	det	the,design
R706	T1345	T1336	conj	design,understanding
R707	T1346	T1345	prep	of,design
R708	T1347	T1348	amod	suitable,therapies
R709	T1348	T1346	pobj	therapies,of
R71	T194	T195	det	These,examples
R710	T1349	T1331	punct	.,enable
R711	T1351	T1352	amod	Few,studies
R712	T1352	T1354	nsubj	studies,exist
R713	T1353	T1352	amod	such,studies
R714	T1355	T1354	prep	for,exist
R715	T1356	T1357	amod	human,LCA
R716	T1357	T1355	pobj	LCA,for
R717	T1358	T1359	punct	(,reviewed
R718	T1359	T1354	parataxis	reviewed,exist
R719	T1360	T1359	prep	in,reviewed
R72	T195	T196	nsubj	examples,include
R720	T1361	T1360	punct	[,in
R721	T1362	T1360	pobj	17,in
R722	T1363	T1359	punct	],reviewed
R723	T1364	T1359	punct	),reviewed
R724	T1365	T1354	cc	and,exist
R725	T1366	T1367	det	the,majority
R726	T1367	T1368	nsubj	majority,examine
R727	T1368	T1354	conj	examine,exist
R728	T1369	T1367	prep	of,majority
R729	T1370	T1371	amod	such,studies
R73	T197	T196	dobj	mutations,include
R730	T1371	T1369	pobj	studies,of
R731	T1372	T1373	det	the,globes
R732	T1373	T1368	dobj	globes,examine
R733	T1374	T1373	prep	of,globes
R734	T1375	T1374	pobj	adults,of
R735	T1376	T1375	prep	with,adults
R736	T1377	T1376	pobj	LCA,with
R737	T1378	T1368	punct	", ",examine
R738	T1379	T1380	mark	after,undergone
R739	T1380	T1368	advcl	undergone,examine
R74	T198	T197	prep	in,mutations
R740	T1381	T1382	det	the,tissue
R741	T1382	T1380	nsubj	tissue,undergone
R742	T1383	T1380	aux	has,undergone
R743	T1384	T1385	amod	secondary,changes
R744	T1385	T1380	dobj	changes,undergone
R745	T1386	T1368	punct	.,examine
R746	T1388	T1389	advmod	Only,study
R747	T1389	T1392	nsubj	study,exists
R748	T1390	T1389	det	a,study
R749	T1391	T1389	amod	single,study
R75	T199	T200	det	the,factor
R750	T1393	T1394	advmod	where,examined
R751	T1394	T1392	ccomp	examined,exists
R752	T1395	T1396	det	the,eye
R753	T1396	T1394	nsubjpass	eye,examined
R754	T1397	T1396	amod	developing,eye
R755	T1398	T1396	prep	of,eye
R756	T1399	T1400	det	an,infant
R757	T1400	T1398	pobj	infant,of
R758	T1401	T1394	auxpass	was,examined
R759	T1402	T1403	punct	[,24
R76	T200	T198	pobj	factor,in
R760	T1403	T1394	parataxis	24,examined
R761	T1404	T1403	punct	],24
R762	T1405	T1392	punct	.,exists
R763	T1407	T1408	compound	Animal,models
R764	T1408	T1409	nsubjpass	models,reported
R765	T1410	T1408	prep	for,models
R766	T1411	T1410	pobj	LCA,for
R767	T1412	T1409	aux	have,reported
R768	T1413	T1409	advmod	recently,reported
R769	T1414	T1409	auxpass	been,reported
R77	T201	T202	compound	photoreceptor,transcription
R770	T1415	T1409	cc	and,reported
R771	T1416	T1417	aux	have,served
R772	T1417	T1409	conj	served,reported
R773	T1418	T1417	advmod	already,served
R774	T1419	T1420	aux	to,broaden
R775	T1420	T1417	xcomp	broaden,served
R776	T1421	T1422	poss	our,understanding
R777	T1422	T1420	dobj	understanding,broaden
R778	T1423	T1422	prep	of,understanding
R779	T1424	T1425	det	the,pathology
R78	T202	T200	compound	transcription,factor
R780	T1425	T1423	pobj	pathology,of
R781	T1426	T1425	prep	of,pathology
R782	T1427	T1428	det	this,disease
R783	T1428	T1426	pobj	disease,of
R784	T1429	T1430	punct	[,25
R785	T1430	T1420	parataxis	25,broaden
R786	T1431	T1432	punct	-,28
R787	T1432	T1430	prep	28,25
R788	T1433	T1430	punct	],25
R789	T1434	T1409	punct	.,reported
R79	T203	T200	punct	", ",factor
R790	T1436	T1437	mark	Since,is
R791	T1437	T1439	advcl	is,are
R792	T1438	T1437	nsubj	LCA,is
R793	T1440	T1441	det	a,disorder
R794	T1441	T1437	attr	disorder,is
R795	T1442	T1443	advmod	clinically,heterogeneous
R796	T1443	T1441	amod	heterogeneous,disorder
R797	T1444	T1442	cc	and,clinically
R798	T1445	T1442	conj	genetically,clinically
R799	T1446	T1439	punct	", ",are
R8	T121	T115	conj	formation,Synaptogenesis
R80	T204	T200	appos	Crx,factor
R800	T1447	T1448	amod	additional,models
R801	T1448	T1439	nsubj	models,are
R802	T1449	T1448	compound	mouse,models
R803	T1450	T1439	prep	in,are
R804	T1451	T1450	pobj	order,in
R805	T1452	T1453	aux	to,allow
R806	T1453	T1439	advcl	allow,are
R807	T1454	T1455	det	a,understanding
R808	T1455	T1453	dobj	understanding,allow
R809	T1456	T1455	amod	full,understanding
R81	T205	T196	punct	.,include
R810	T1457	T1455	prep	of,understanding
R811	T1458	T1459	det	the,ways
R812	T1459	T1457	pobj	ways,of
R813	T1460	T1459	amod	many,ways
R814	T1461	T1462	prep	in,go
R815	T1462	T1459	relcl	go,ways
R816	T1463	T1461	pobj	which,in
R817	T1464	T1465	compound	photoreceptor,development
R818	T1465	T1462	nsubj	development,go
R819	T1466	T1462	aux	can,go
R82	T209	T210	det	A,strain
R820	T1483	T1471	nsubj	cells,serve
R821	T1467	T1462	advcl	awry,go
R822	T1484	T1471	prep	as,serve
R823	T1468	T1439	punct	.,are
R824	T1485	T1486	det	an,model
R825	T1486	T1484	pobj	model,as
R826	T1470	T1471	prep	In,serve
R827	T1487	T1486	amod	excellent,model
R828	T1488	T1486	prep	for,model
R829	T1489	T1488	pobj	studies,for
R83	T210	T213	nsubjpass	strain,created
R830	T1490	T1489	prep	in,studies
R831	T1491	T1492	amod	neuronal,differentiation
R832	T1492	T1490	pobj	differentiation,in
R833	T1493	T1471	punct	.,serve
R834	T1472	T1470	pobj	addition,In
R835	T1495	T1496	compound	Photoreceptor,cells
R836	T1496	T1497	nsubj	cells,are
R837	T1473	T1472	prep	to,addition
R838	T1498	T1499	advmod	highly,polarized
R839	T1499	T1497	acomp	polarized,are
R84	T211	T210	nmod	Crx,strain
R840	T1474	T1475	poss	their,importance
R841	T1500	T1497	punct	.,are
R842	T1475	T1473	pobj	importance,to
R843	T1502	T1503	prep	At,have
R844	T1504	T1505	poss	their,apex
R845	T1476	T1475	prep	as,importance
R846	T1505	T1502	pobj	apex,At
R847	T1506	T1503	punct	", ",have
R848	T1477	T1478	det	a,locus
R849	T1507	T1508	det	these,neurons
R85	T212	T210	amod	mutant,strain
R850	T1508	T1503	nsubj	neurons,have
R851	T1509	T1510	det	a,segment
R852	T1478	T1476	pobj	locus,as
R853	T1510	T1503	dobj	segment,have
R854	T1511	T1510	amod	membranous,segment
R855	T1479	T1478	prep	of,locus
R856	T1512	T1510	amod	outer,segment
R857	T1480	T1479	pobj	disease,of
R858	T1481	T1471	punct	", ",serve
R859	T1513	T1510	punct	", ",segment
R86	T214	T210	prep	of,strain
R860	T1514	T1515	dep	which,contains
R861	T1515	T1510	relcl	contains,segment
R862	T1482	T1483	compound	photoreceptor,cells
R863	T1516	T1515	dobj	proteins,contains
R864	T1589	T1590	nmod	rod,dendrites
R865	T1517	T1516	acl	involved,proteins
R866	T1518	T1517	prep	in,involved
R867	T1519	T1520	det	the,cascade
R868	T1520	T1518	pobj	cascade,in
R869	T1521	T1520	compound	phototransduction,cascade
R87	T215	T214	pobj	mice,of
R870	T1590	T1588	pobj	dendrites,with
R871	T1522	T1503	punct	.,have
R872	T1591	T1590	amod	bipolar,dendrites
R873	T1524	T1525	nmod	Loss,mutations
R874	T1525	T1528	nsubj	mutations,result
R875	T1592	T1590	cc	and,dendrites
R876	T1526	T1524	prep	of,Loss
R877	T1527	T1526	pobj	function,of
R878	T1593	T1594	amod	axonal,endings
R879	T1529	T1525	prep	in,mutations
R88	T216	T213	auxpass	was,created
R880	T1530	T1529	pobj	rhodopsin,in
R881	T1531	T1532	punct	[,29
R882	T1532	T1530	parataxis	29,rhodopsin
R883	T1533	T1532	punct	],29
R884	T1534	T1530	punct	", ",rhodopsin
R885	T1594	T1590	conj	endings,dendrites
R886	T1535	T1530	cc	or,rhodopsin
R887	T1536	T1537	det	the,protein
R888	T1537	T1530	conj	protein,rhodopsin
R889	T1538	T1537	amod	structural,protein
R89	T217	T218	aux	to,serve
R890	T1595	T1594	prep	of,endings
R891	T1539	T1537	punct	", ",protein
R892	T1540	T1537	appos	peripherin,protein
R893	T1596	T1597	amod	horizontal,cells
R894	T1541	T1542	punct	[,30
R895	T1542	T1540	parataxis	30,peripherin
R896	T1597	T1595	pobj	cells,of
R897	T1543	T1542	punct	],30
R898	T1544	T1528	punct	", ",result
R899	T1545	T1528	prep	in,result
R9	T122	T116	auxpass	are,perturbed
R90	T218	T213	advcl	serve,created
R900	T1598	T1584	punct	.,establish
R901	T1546	T1547	det	an,inability
R902	T1547	T1545	pobj	inability,in
R903	T1548	T1549	aux	to,form
R904	T1600	T1601	det	This,synapse
R905	T1549	T1547	acl	form,inability
R906	T1550	T1551	amod	outer,segments
R907	T1551	T1549	dobj	segments,form
R908	T1552	T1528	punct	.,result
R909	T1601	T1602	nsubjpass	synapse,characterized
R91	T219	T218	prep	as,serve
R910	T1554	T1555	prep	At,terminate
R911	T1556	T1557	det	the,extremity
R912	T1603	T1602	auxpass	is,characterized
R913	T1557	T1554	pobj	extremity,At
R914	T1558	T1557	amod	other,extremity
R915	T1559	T1555	punct	", ",terminate
R916	T1604	T1602	agent	by,characterized
R917	T1560	T1555	nsubj	photoreceptors,terminate
R918	T1561	T1555	prep	with,terminate
R919	T1562	T1563	amod	synaptic,endings
R92	T220	T221	det	a,model
R920	T1563	T1561	pobj	endings,with
R921	T1605	T1606	det	the,presence
R922	T1564	T1565	dep	that,make
R923	T1565	T1563	relcl	make,endings
R924	T1566	T1565	dobj	contact,make
R925	T1606	T1604	pobj	presence,by
R926	T1567	T1565	prep	with,make
R927	T1568	T1569	det	the,processes
R928	T1569	T1567	pobj	processes,with
R929	T1607	T1606	prep	of,presence
R93	T221	T219	pobj	model,as
R930	T1570	T1569	prep	of,processes
R931	T1571	T1572	amod	horizontal,cells
R932	T1572	T1570	pobj	cells,of
R933	T1573	T1571	cc	and,horizontal
R934	T1574	T1571	conj	bipolar,horizontal
R935	T1575	T1576	punct	[,32
R936	T1608	T1609	det	a,ribbon
R937	T1576	T1565	parataxis	32,make
R938	T1577	T1576	nummod	31,32
R939	T1578	T1576	punct	",",32
R94	T222	T221	prep	for,model
R940	T1579	T1576	punct	],32
R941	T1609	T1607	pobj	ribbon,of
R942	T1580	T1555	punct	.,terminate
R943	T1582	T1583	compound	Rod,spherules
R944	T1610	T1606	prep	in,presence
R945	T1583	T1584	nsubj	spherules,establish
R946	T1611	T1612	det	the,cytoplasm
R947	T1585	T1586	det	an,synapse
R948	T1586	T1584	dobj	synapse,establish
R949	T1587	T1586	amod	invaginating,synapse
R95	T223	T222	pobj	LCA,for
R950	T1588	T1586	prep	with,synapse
R951	T1612	T1610	pobj	cytoplasm,in
R952	T1613	T1612	amod	presynaptic,cytoplasm
R953	T1614	T1602	punct	.,characterized
R954	T1616	T1617	compound	Cone,pedicles
R955	T1695	T1688	dobj	examination,extended
R956	T1696	T1695	prep	of,examination
R957	T1617	T1618	nsubj	pedicles,make
R958	T1697	T1698	amod	retinal,pathology
R959	T1698	T1696	pobj	pathology,of
R96	T224	T218	cc	and,serve
R960	T1619	T1620	amod	invaginating,synapses
R961	T1699	T1688	prep	to,extended
R962	T1700	T1701	det	the,level
R963	T1701	T1699	pobj	level,to
R964	T1702	T1701	amod	ultrastructural,level
R965	T1620	T1618	dobj	synapses,make
R966	T1703	T1688	punct	.,extended
R967	T1621	T1618	prep	with,make
R968	T1705	T1706	amod	Certain,features
R969	T1706	T1707	nsubjpass	features,detected
R97	T225	T226	aux	to,provide
R970	T1622	T1623	det	the,dendrites
R971	T1708	T1706	prep	of,features
R972	T1709	T1710	amod	neuronal,differentiation
R973	T1623	T1621	pobj	dendrites,with
R974	T1710	T1708	pobj	differentiation,of
R975	T1711	T1706	punct	", ",features
R976	T1624	T1623	prep	of,dendrites
R977	T1712	T1713	amod	such,as
R978	T1713	T1706	prep	as,features
R979	T1714	T1715	compound	synapse,formation
R98	T226	T218	conj	provide,serve
R980	T1625	T1626	nmod	on,cells
R981	T1715	T1713	pobj	formation,as
R982	T1716	T1707	punct	", ",detected
R983	T1717	T1707	aux	can,detected
R984	T1626	T1624	pobj	cells,of
R985	T1718	T1707	auxpass	be,detected
R986	T1719	T1707	advmod	definitively,detected
R987	T1720	T1707	prep	at,detected
R988	T1721	T1722	det	this,level
R989	T1722	T1720	pobj	level,at
R99	T227	T228	amod	more,insight
R990	T1723	T1722	prep	of,level
R991	T1627	T1625	punct	-,on
R992	T1724	T1723	pobj	analysis,of
R993	T1725	T1707	punct	.,detected
R994	T1628	T1625	pobj	cone,on
R995	T1727	T1728	prep	With,analyzed
R996	T1729	T1730	det	the,hope
R997	T1629	T1626	amod	bipolar,cells
R998	T1730	T1727	pobj	hope,With
R999	T1731	T1730	prep	of,hope

PMC:548520 JSONTXT 8 Projects

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PMC:548520 JSON TXT 8 Projects