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PMC:539297 / 582-1416 JSONTXT 4 Projects

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Id Subject Object Predicate Lexical cue
T272 0-7 NNS denotes Results
T273 7-315 sentence denotes To elucidate the consequences of the common JNCL mutation in neuronal cells, we used P4 knock-in mouse cerebella to establish conditionally immortalized CbCln3 wild-type, heterozygous, and homozygous neuronal precursor cell lines, which can be differentiated into MAP-2 and NeuN-positive, neuron-like cells.
T274 8-10 TO denotes To
T275 11-20 VB denotes elucidate
T277 21-24 DT denotes the
T278 25-37 NNS denotes consequences
T279 38-40 IN denotes of
T280 41-44 DT denotes the
T282 45-51 JJ denotes common
T283 52-56 NN denotes JNCL
T281 57-65 NN denotes mutation
T284 66-68 IN denotes in
T285 69-77 JJ denotes neuronal
T286 78-83 NNS denotes cells
T287 83-85 , denotes ,
T288 85-87 PRP denotes we
T276 88-92 VBD denotes used
T289 93-95 NN denotes P4
T291 96-101 VB denotes knock
T292 101-102 HYPH denotes -
T293 102-104 RP denotes in
T294 105-110 NN denotes mouse
T290 111-120 NNS denotes cerebella
T295 121-123 TO denotes to
T296 124-133 VB denotes establish
T297 134-147 RB denotes conditionally
T298 148-160 VBN denotes immortalized
T300 161-167 NN denotes CbCln3
T301 168-172 JJ denotes wild
T303 172-173 HYPH denotes -
T302 173-177 NN denotes type
T304 177-179 , denotes ,
T305 179-191 JJ denotes heterozygous
T306 191-193 , denotes ,
T307 193-196 CC denotes and
T308 197-207 JJ denotes homozygous
T309 208-216 JJ denotes neuronal
T310 217-226 NN denotes precursor
T311 227-231 NN denotes cell
T299 232-237 NNS denotes lines
T312 237-239 , denotes ,
T313 239-244 WDT denotes which
T315 245-248 MD denotes can
T316 249-251 VB denotes be
T314 252-266 VBN denotes differentiated
T317 267-271 IN denotes into
T318 272-275 NN denotes MAP
T320 275-276 HYPH denotes -
T321 276-277 CD denotes 2
T322 278-281 CC denotes and
T323 282-286 NN denotes NeuN
T324 286-287 HYPH denotes -
T319 287-295 JJ denotes positive
T326 295-297 , denotes ,
T327 297-303 NN denotes neuron
T329 303-304 HYPH denotes -
T328 304-308 JJ denotes like
T325 309-314 NNS denotes cells
T330 314-315 . denotes .
T331 315-452 sentence denotes Homozygous CbCln3Δex7/8 precursor cells express low levels of mutant battenin and, when aged at confluency, accumulate ATPase subunit c.
T332 316-326 JJ denotes Homozygous
T334 327-337 NN denotes CbCln3Δex7
T335 337-338 HYPH denotes /
T336 338-339 CD denotes 8
T337 340-349 NN denotes precursor
T333 350-355 NNS denotes cells
T338 356-363 VBP denotes express
T339 364-367 JJ denotes low
T340 368-374 NNS denotes levels
T341 375-377 IN denotes of
T342 378-384 NN denotes mutant
T343 385-393 NN denotes battenin
T344 394-397 CC denotes and
T345 397-399 , denotes ,
T346 399-403 WRB denotes when
T347 404-408 VBN denotes aged
T349 409-411 IN denotes at
T350 412-422 NN denotes confluency
T351 422-424 , denotes ,
T348 424-434 VBP denotes accumulate
T352 435-441 NN denotes ATPase
T354 442-449 NN denotes subunit
T353 450-451 NN denotes c
T355 451-452 . denotes .
T356 452-695 sentence denotes Recessive phenotypes are also observed at sub-confluent growth; cathepsin D transport and processing are altered, although enzyme activity is not significantly affected, lysosomal size and distribution are altered, and endocytosis is reduced.
T357 453-462 JJ denotes Recessive
T358 463-473 NNS denotes phenotypes
T360 474-477 VBP denotes are
T361 478-482 RB denotes also
T359 483-491 VBN denotes observed
T362 492-494 IN denotes at
T363 495-508 JJ denotes sub-confluent
T364 509-515 NN denotes growth
T365 515-516 : denotes ;
T366 517-526 NN denotes cathepsin
T367 527-528 NN denotes D
T369 529-538 NN denotes transport
T370 539-542 CC denotes and
T371 543-553 NN denotes processing
T372 554-557 VBP denotes are
T368 558-565 VBN denotes altered
T373 565-567 , denotes ,
T374 567-575 IN denotes although
T376 576-582 NN denotes enzyme
T377 583-591 NN denotes activity
T378 592-594 VBZ denotes is
T379 595-598 RB denotes not
T380 599-612 RB denotes significantly
T375 613-621 VBN denotes affected
T382 621-623 , denotes ,
T383 623-632 JJ denotes lysosomal
T384 633-637 NN denotes size
T385 638-641 CC denotes and
T386 642-654 NN denotes distribution
T387 655-658 VBP denotes are
T381 659-666 VBN denotes altered
T388 666-668 , denotes ,
T389 668-671 CC denotes and
T390 672-683 NN denotes endocytosis
T392 684-686 VBZ denotes is
T391 687-694 VBN denotes reduced
T393 694-695 . denotes .
T394 695-834 sentence denotes In addition, mitochondria are abnormally elongated, cellular ATP levels are decreased, and survival following oxidative stress is reduced.
T395 696-698 IN denotes In
T397 699-707 NN denotes addition
T398 707-709 , denotes ,
T399 709-721 NNS denotes mitochondria
T396 722-725 VBP denotes are
T400 726-736 RB denotes abnormally
T401 737-746 JJ denotes elongated
T402 746-748 , denotes ,
T403 748-756 JJ denotes cellular
T405 757-760 NN denotes ATP
T404 761-767 NNS denotes levels
T407 768-771 VBP denotes are
T406 772-781 VBN denotes decreased
T408 781-783 , denotes ,
T409 783-786 CC denotes and
T410 787-795 NN denotes survival
T412 796-805 VBG denotes following
T413 806-815 JJ denotes oxidative
T414 816-822 NN denotes stress
T415 823-825 VBZ denotes is
T411 826-833 VBN denotes reduced
T416 833-834 . denotes .
R100 T283 T281 compound JNCL,mutation
R101 T284 T278 prep in,consequences
R102 T285 T286 amod neuronal,cells
R103 T286 T284 pobj cells,in
R104 T287 T276 punct ", ",used
R105 T288 T276 nsubj we,used
R106 T289 T290 nmod P4,cerebella
R107 T290 T276 dobj cerebella,used
R108 T291 T290 amod knock,cerebella
R109 T292 T291 punct -,knock
R110 T293 T291 prt in,knock
R111 T294 T290 compound mouse,cerebella
R112 T295 T296 aux to,establish
R113 T296 T276 advcl establish,used
R114 T297 T298 advmod conditionally,immortalized
R115 T298 T299 amod immortalized,lines
R116 T299 T296 dobj lines,establish
R117 T300 T299 nmod CbCln3,lines
R118 T301 T302 amod wild,type
R119 T302 T299 nmod type,lines
R120 T303 T302 punct -,type
R121 T304 T302 punct ", ",type
R122 T305 T302 conj heterozygous,type
R123 T306 T305 punct ", ",heterozygous
R124 T307 T305 cc and,heterozygous
R125 T308 T305 conj homozygous,heterozygous
R126 T309 T310 amod neuronal,precursor
R127 T310 T299 compound precursor,lines
R128 T311 T299 compound cell,lines
R129 T312 T299 punct ", ",lines
R130 T313 T314 dep which,differentiated
R131 T314 T299 relcl differentiated,lines
R132 T315 T314 aux can,differentiated
R133 T316 T314 auxpass be,differentiated
R134 T317 T314 prep into,differentiated
R135 T318 T319 npadvmod MAP,positive
R136 T319 T325 amod positive,cells
R137 T320 T318 punct -,MAP
R138 T321 T318 nummod 2,MAP
R139 T322 T318 cc and,MAP
R140 T323 T318 conj NeuN,MAP
R141 T324 T319 punct -,positive
R142 T325 T317 pobj cells,into
R143 T326 T325 punct ", ",cells
R144 T327 T328 npadvmod neuron,like
R145 T328 T325 amod like,cells
R146 T329 T328 punct -,like
R147 T330 T276 punct .,used
R148 T332 T333 amod Homozygous,cells
R149 T333 T338 nsubj cells,express
R150 T334 T333 nmod CbCln3Δex7,cells
R151 T335 T334 punct /,CbCln3Δex7
R152 T336 T334 nummod 8,CbCln3Δex7
R153 T337 T333 compound precursor,cells
R154 T339 T340 amod low,levels
R155 T340 T338 dobj levels,express
R156 T341 T340 prep of,levels
R157 T342 T343 compound mutant,battenin
R158 T343 T341 pobj battenin,of
R159 T344 T338 cc and,express
R160 T345 T338 punct ", ",express
R161 T346 T347 advmod when,aged
R162 T347 T348 advcl aged,accumulate
R163 T348 T338 conj accumulate,express
R164 T349 T347 prep at,aged
R165 T350 T349 pobj confluency,at
R166 T351 T348 punct ", ",accumulate
R167 T352 T353 compound ATPase,c
R168 T353 T348 dobj c,accumulate
R169 T354 T353 compound subunit,c
R170 T355 T338 punct .,express
R171 T357 T358 amod Recessive,phenotypes
R172 T358 T359 nsubjpass phenotypes,observed
R173 T360 T359 auxpass are,observed
R174 T361 T359 advmod also,observed
R175 T362 T359 prep at,observed
R176 T363 T364 amod sub-confluent,growth
R177 T364 T362 pobj growth,at
R178 T365 T359 punct ;,observed
R179 T366 T367 compound cathepsin,D
R180 T367 T368 nsubjpass D,altered
R181 T368 T359 conj altered,observed
R182 T369 T367 appos transport,D
R183 T370 T369 cc and,transport
R184 T371 T369 conj processing,transport
R185 T372 T368 auxpass are,altered
R186 T373 T368 punct ", ",altered
R187 T374 T375 mark although,affected
R188 T375 T381 advcl affected,altered
R189 T376 T377 compound enzyme,activity
R190 T377 T375 nsubjpass activity,affected
R191 T378 T375 auxpass is,affected
R192 T379 T375 neg not,affected
R193 T380 T375 advmod significantly,affected
R194 T381 T368 conj altered,altered
R195 T382 T381 punct ", ",altered
R196 T383 T384 amod lysosomal,size
R197 T384 T381 nsubjpass size,altered
R198 T385 T384 cc and,size
R199 T386 T384 conj distribution,size
R200 T387 T381 auxpass are,altered
R201 T388 T381 punct ", ",altered
R202 T389 T381 cc and,altered
R203 T390 T391 nsubjpass endocytosis,reduced
R204 T391 T381 conj reduced,altered
R205 T392 T391 auxpass is,reduced
R206 T393 T391 punct .,reduced
R207 T395 T396 prep In,are
R208 T397 T395 pobj addition,In
R209 T398 T396 punct ", ",are
R210 T399 T396 nsubj mitochondria,are
R211 T400 T401 advmod abnormally,elongated
R212 T401 T396 acomp elongated,are
R213 T402 T396 punct ", ",are
R214 T403 T404 amod cellular,levels
R215 T404 T406 nsubjpass levels,decreased
R216 T405 T404 compound ATP,levels
R217 T406 T396 conj decreased,are
R218 T407 T406 auxpass are,decreased
R219 T408 T406 punct ", ",decreased
R220 T409 T406 cc and,decreased
R221 T410 T411 nsubjpass survival,reduced
R222 T411 T406 conj reduced,decreased
R223 T412 T410 prep following,survival
R224 T413 T414 amod oxidative,stress
R225 T414 T412 pobj stress,following
R226 T415 T411 auxpass is,reduced
R227 T416 T396 punct .,are
R92 T274 T275 aux To,elucidate
R93 T275 T276 advcl elucidate,used
R94 T277 T278 det the,consequences
R95 T278 T275 dobj consequences,elucidate
R96 T279 T278 prep of,consequences
R97 T280 T281 det the,mutation
R98 T281 T279 pobj mutation,of
R99 T282 T281 amod common,mutation