| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T4515 |
0-8 |
JJ |
denotes |
Abnormal |
| T4517 |
9-18 |
NN |
denotes |
cathepsin |
| T4516 |
19-20 |
NN |
denotes |
D |
| T4519 |
21-33 |
NN |
denotes |
localization |
| T4520 |
34-37 |
CC |
denotes |
and |
| T4521 |
38-48 |
NN |
denotes |
processing |
| T4522 |
49-51 |
IN |
denotes |
in |
| T4523 |
52-62 |
JJ |
denotes |
homozygous |
| T4525 |
63-73 |
NN |
denotes |
CbCln3Δex7 |
| T4526 |
73-74 |
HYPH |
denotes |
/ |
| T4527 |
74-75 |
CD |
denotes |
8 |
| T4524 |
76-81 |
NNS |
denotes |
cells |
| T4528 |
82-85 |
CC |
denotes |
and |
| T4529 |
86-94 |
NN |
denotes |
Cln3Δex7 |
| T4531 |
94-95 |
HYPH |
denotes |
/ |
| T4532 |
95-96 |
CD |
denotes |
8 |
| T4530 |
97-101 |
NNS |
denotes |
mice |
| T4533 |
102-108 |
RB |
denotes |
likely |
| T4518 |
109-117 |
VBZ |
denotes |
reflects |
| T4534 |
118-125 |
VBN |
denotes |
altered |
| T4536 |
126-135 |
JJ |
denotes |
vesicular |
| T4535 |
136-147 |
NN |
denotes |
trafficking |
| T4537 |
148-151 |
CC |
denotes |
and |
| T4538 |
151-152 |
HYPH |
denotes |
/ |
| T4539 |
152-154 |
CC |
denotes |
or |
| T4540 |
155-164 |
JJ |
denotes |
lysosomal |
| T4541 |
165-167 |
NN |
denotes |
pH |
| T4542 |
167-169 |
, |
denotes |
, |
| T4543 |
169-174 |
WDT |
denotes |
which |
| T4545 |
175-177 |
VBZ |
denotes |
is |
| T4544 |
178-183 |
VBN |
denotes |
known |
| T4546 |
184-186 |
TO |
denotes |
to |
| T4547 |
187-193 |
VB |
denotes |
impact |
| T4548 |
194-203 |
NN |
denotes |
cathepsin |
| T4549 |
204-205 |
NN |
denotes |
D |
| T4550 |
206-216 |
NN |
denotes |
processing |
| T4551 |
217-218 |
-LRB- |
denotes |
[ |
| T4553 |
218-220 |
CD |
denotes |
14 |
| T4554 |
220-221 |
, |
denotes |
, |
| T4552 |
221-223 |
CD |
denotes |
16 |
| T4555 |
223-224 |
-RRB- |
denotes |
] |
| T4556 |
224-225 |
. |
denotes |
. |
| T4557 |
225-383 |
sentence |
denotes |
Indeed, CLN3 overexpression in HEK-293 cells altered lysosomal pH and cathepsin D processing [17], and lysosomal pH homeostasis is disrupted in JNCL [10,15]. |
| T4558 |
226-232 |
RB |
denotes |
Indeed |
| T4560 |
232-234 |
, |
denotes |
, |
| T4561 |
234-238 |
NN |
denotes |
CLN3 |
| T4562 |
239-253 |
NN |
denotes |
overexpression |
| T4563 |
254-256 |
IN |
denotes |
in |
| T4564 |
257-260 |
NN |
denotes |
HEK |
| T4566 |
260-261 |
HYPH |
denotes |
- |
| T4567 |
261-264 |
CD |
denotes |
293 |
| T4565 |
265-270 |
NNS |
denotes |
cells |
| T4559 |
271-278 |
VBD |
denotes |
altered |
| T4568 |
279-288 |
JJ |
denotes |
lysosomal |
| T4569 |
289-291 |
NN |
denotes |
pH |
| T4571 |
292-295 |
CC |
denotes |
and |
| T4572 |
296-305 |
NN |
denotes |
cathepsin |
| T4573 |
306-307 |
NN |
denotes |
D |
| T4570 |
308-318 |
NN |
denotes |
processing |
| T4574 |
319-320 |
-LRB- |
denotes |
[ |
| T4575 |
320-322 |
CD |
denotes |
17 |
| T4576 |
322-323 |
-RRB- |
denotes |
] |
| T4577 |
323-325 |
, |
denotes |
, |
| T4578 |
325-328 |
CC |
denotes |
and |
| T4579 |
329-338 |
JJ |
denotes |
lysosomal |
| T4580 |
339-341 |
NN |
denotes |
pH |
| T4581 |
342-353 |
NN |
denotes |
homeostasis |
| T4583 |
354-356 |
VBZ |
denotes |
is |
| T4582 |
357-366 |
VBN |
denotes |
disrupted |
| T4584 |
367-369 |
IN |
denotes |
in |
| T4585 |
370-374 |
NN |
denotes |
JNCL |
| T4586 |
375-376 |
-LRB- |
denotes |
[ |
| T4588 |
376-378 |
CD |
denotes |
10 |
| T4589 |
378-379 |
, |
denotes |
, |
| T4587 |
379-381 |
CD |
denotes |
15 |
| T4590 |
381-382 |
-RRB- |
denotes |
] |
| T4591 |
382-383 |
. |
denotes |
. |
| T4592 |
383-486 |
sentence |
denotes |
It is noteworthy that cathepsin B and the CLN2-encoded enzyme, TPPI, are also altered in JNCL [18-20]. |
| T4593 |
384-386 |
PRP |
denotes |
It |
| T4594 |
387-389 |
VBZ |
denotes |
is |
| T4595 |
390-400 |
JJ |
denotes |
noteworthy |
| T4596 |
401-405 |
IN |
denotes |
that |
| T4598 |
406-415 |
NN |
denotes |
cathepsin |
| T4599 |
416-417 |
NN |
denotes |
B |
| T4600 |
418-421 |
CC |
denotes |
and |
| T4601 |
422-425 |
DT |
denotes |
the |
| T4603 |
426-430 |
NN |
denotes |
CLN2 |
| T4605 |
430-431 |
HYPH |
denotes |
- |
| T4604 |
431-438 |
VBN |
denotes |
encoded |
| T4602 |
439-445 |
NN |
denotes |
enzyme |
| T4606 |
445-447 |
, |
denotes |
, |
| T4607 |
447-451 |
NN |
denotes |
TPPI |
| T4608 |
451-453 |
, |
denotes |
, |
| T4609 |
453-456 |
VBP |
denotes |
are |
| T4610 |
457-461 |
RB |
denotes |
also |
| T4597 |
462-469 |
VBN |
denotes |
altered |
| T4611 |
470-472 |
IN |
denotes |
in |
| T4612 |
473-477 |
NN |
denotes |
JNCL |
| T4613 |
478-479 |
-LRB- |
denotes |
[ |
| T4614 |
479-481 |
CD |
denotes |
18 |
| T4615 |
481-482 |
SYM |
denotes |
- |
| T4616 |
482-484 |
CD |
denotes |
20 |
| T4617 |
484-485 |
-RRB- |
denotes |
] |
| T4618 |
485-486 |
. |
denotes |
. |
| T4619 |
486-658 |
sentence |
denotes |
Nevertheless, despite the cathepsin D protein alterations that are observed in homozygous CbCln3Δex7/8 cells, cathepsin D enzymatic activity does not appear to be reduced. |
| T4620 |
487-499 |
RB |
denotes |
Nevertheless |
| T4622 |
499-501 |
, |
denotes |
, |
| T4623 |
501-508 |
IN |
denotes |
despite |
| T4624 |
509-512 |
DT |
denotes |
the |
| T4626 |
513-522 |
NN |
denotes |
cathepsin |
| T4627 |
523-524 |
NN |
denotes |
D |
| T4628 |
525-532 |
NN |
denotes |
protein |
| T4625 |
533-544 |
NNS |
denotes |
alterations |
| T4629 |
545-549 |
WDT |
denotes |
that |
| T4631 |
550-553 |
VBP |
denotes |
are |
| T4630 |
554-562 |
VBN |
denotes |
observed |
| T4632 |
563-565 |
IN |
denotes |
in |
| T4633 |
566-576 |
JJ |
denotes |
homozygous |
| T4635 |
577-587 |
NN |
denotes |
CbCln3Δex7 |
| T4636 |
587-588 |
HYPH |
denotes |
/ |
| T4637 |
588-589 |
CD |
denotes |
8 |
| T4634 |
590-595 |
NNS |
denotes |
cells |
| T4638 |
595-597 |
, |
denotes |
, |
| T4639 |
597-606 |
NN |
denotes |
cathepsin |
| T4640 |
607-608 |
NN |
denotes |
D |
| T4642 |
609-618 |
JJ |
denotes |
enzymatic |
| T4641 |
619-627 |
NN |
denotes |
activity |
| T4643 |
628-632 |
VBZ |
denotes |
does |
| T4644 |
633-636 |
RB |
denotes |
not |
| T4621 |
637-643 |
VB |
denotes |
appear |
| T4645 |
644-646 |
TO |
denotes |
to |
| T4647 |
647-649 |
VB |
denotes |
be |
| T4646 |
650-657 |
VBN |
denotes |
reduced |
| T4648 |
657-658 |
. |
denotes |
. |
| T4649 |
658-754 |
sentence |
denotes |
Thus, decreased cathepsin D activity is unlikely to account for subunit c accumulation in JNCL. |
| T4650 |
659-663 |
RB |
denotes |
Thus |
| T4652 |
663-665 |
, |
denotes |
, |
| T4653 |
665-674 |
VBN |
denotes |
decreased |
| T4655 |
675-684 |
NN |
denotes |
cathepsin |
| T4656 |
685-686 |
NN |
denotes |
D |
| T4654 |
687-695 |
NN |
denotes |
activity |
| T4651 |
696-698 |
VBZ |
denotes |
is |
| T4657 |
699-707 |
JJ |
denotes |
unlikely |
| T4658 |
708-710 |
TO |
denotes |
to |
| T4659 |
711-718 |
VB |
denotes |
account |
| T4660 |
719-722 |
IN |
denotes |
for |
| T4661 |
723-730 |
NN |
denotes |
subunit |
| T4662 |
731-732 |
NN |
denotes |
c |
| T4663 |
733-745 |
NN |
denotes |
accumulation |
| T4664 |
746-748 |
IN |
denotes |
in |
| T4665 |
749-753 |
NN |
denotes |
JNCL |
| T4666 |
753-754 |
. |
denotes |
. |
| R2474 |
T4515 |
T4516 |
amod |
Abnormal,D |
| R2475 |
T4516 |
T4518 |
nsubj |
D,reflects |
| R2476 |
T4517 |
T4516 |
compound |
cathepsin,D |
| R2477 |
T4519 |
T4516 |
appos |
localization,D |
| R2478 |
T4520 |
T4519 |
cc |
and,localization |
| R2479 |
T4521 |
T4519 |
conj |
processing,localization |
| R2480 |
T4522 |
T4516 |
prep |
in,D |
| R2481 |
T4523 |
T4524 |
amod |
homozygous,cells |
| R2482 |
T4524 |
T4522 |
pobj |
cells,in |
| R2483 |
T4525 |
T4524 |
nmod |
CbCln3Δex7,cells |
| R2484 |
T4526 |
T4525 |
punct |
/,CbCln3Δex7 |
| R2485 |
T4527 |
T4525 |
nummod |
8,CbCln3Δex7 |
| R2486 |
T4528 |
T4524 |
cc |
and,cells |
| R2487 |
T4529 |
T4530 |
nmod |
Cln3Δex7,mice |
| R2488 |
T4530 |
T4524 |
conj |
mice,cells |
| R2489 |
T4531 |
T4529 |
punct |
/,Cln3Δex7 |
| R2490 |
T4532 |
T4529 |
nummod |
8,Cln3Δex7 |
| R2491 |
T4533 |
T4518 |
advmod |
likely,reflects |
| R2492 |
T4534 |
T4535 |
amod |
altered,trafficking |
| R2493 |
T4535 |
T4518 |
dobj |
trafficking,reflects |
| R2494 |
T4536 |
T4535 |
amod |
vesicular,trafficking |
| R2495 |
T4537 |
T4535 |
cc |
and,trafficking |
| R2496 |
T4538 |
T4535 |
punct |
/,trafficking |
| R2497 |
T4539 |
T4535 |
cc |
or,trafficking |
| R2498 |
T4540 |
T4541 |
amod |
lysosomal,pH |
| R2499 |
T4541 |
T4535 |
conj |
pH,trafficking |
| R2500 |
T4542 |
T4535 |
punct |
", ",trafficking |
| R2501 |
T4543 |
T4544 |
dep |
which,known |
| R2502 |
T4544 |
T4535 |
relcl |
known,trafficking |
| R2503 |
T4545 |
T4544 |
auxpass |
is,known |
| R2504 |
T4546 |
T4547 |
aux |
to,impact |
| R2505 |
T4547 |
T4544 |
xcomp |
impact,known |
| R2506 |
T4548 |
T4549 |
compound |
cathepsin,D |
| R2507 |
T4549 |
T4550 |
compound |
D,processing |
| R2508 |
T4550 |
T4547 |
dobj |
processing,impact |
| R2509 |
T4551 |
T4552 |
punct |
[,16 |
| R2510 |
T4552 |
T4544 |
parataxis |
16,known |
| R2511 |
T4553 |
T4552 |
nummod |
14,16 |
| R2512 |
T4554 |
T4552 |
punct |
",",16 |
| R2513 |
T4555 |
T4552 |
punct |
],16 |
| R2514 |
T4556 |
T4518 |
punct |
.,reflects |
| R2515 |
T4558 |
T4559 |
advmod |
Indeed,altered |
| R2516 |
T4560 |
T4559 |
punct |
", ",altered |
| R2517 |
T4561 |
T4562 |
compound |
CLN3,overexpression |
| R2518 |
T4562 |
T4559 |
nsubj |
overexpression,altered |
| R2519 |
T4563 |
T4562 |
prep |
in,overexpression |
| R2520 |
T4564 |
T4565 |
nmod |
HEK,cells |
| R2521 |
T4565 |
T4563 |
pobj |
cells,in |
| R2522 |
T4566 |
T4564 |
punct |
-,HEK |
| R2523 |
T4567 |
T4564 |
nummod |
293,HEK |
| R2524 |
T4568 |
T4569 |
amod |
lysosomal,pH |
| R2525 |
T4569 |
T4570 |
nmod |
pH,processing |
| R2526 |
T4570 |
T4559 |
dobj |
processing,altered |
| R2527 |
T4571 |
T4569 |
cc |
and,pH |
| R2528 |
T4572 |
T4573 |
compound |
cathepsin,D |
| R2529 |
T4573 |
T4569 |
conj |
D,pH |
| R2530 |
T4574 |
T4575 |
punct |
[,17 |
| R2531 |
T4575 |
T4559 |
parataxis |
17,altered |
| R2532 |
T4576 |
T4575 |
punct |
],17 |
| R2533 |
T4577 |
T4559 |
punct |
", ",altered |
| R2534 |
T4578 |
T4559 |
cc |
and,altered |
| R2535 |
T4579 |
T4580 |
amod |
lysosomal,pH |
| R2536 |
T4580 |
T4581 |
compound |
pH,homeostasis |
| R2537 |
T4581 |
T4582 |
nsubjpass |
homeostasis,disrupted |
| R2538 |
T4582 |
T4559 |
conj |
disrupted,altered |
| R2539 |
T4583 |
T4582 |
auxpass |
is,disrupted |
| R2540 |
T4584 |
T4582 |
prep |
in,disrupted |
| R2541 |
T4585 |
T4584 |
pobj |
JNCL,in |
| R2542 |
T4586 |
T4587 |
punct |
[,15 |
| R2543 |
T4587 |
T4582 |
parataxis |
15,disrupted |
| R2544 |
T4588 |
T4587 |
nummod |
10,15 |
| R2545 |
T4589 |
T4587 |
punct |
",",15 |
| R2546 |
T4590 |
T4587 |
punct |
],15 |
| R2547 |
T4591 |
T4582 |
punct |
.,disrupted |
| R2548 |
T4593 |
T4594 |
nsubj |
It,is |
| R2549 |
T4595 |
T4594 |
acomp |
noteworthy,is |
| R2550 |
T4596 |
T4597 |
mark |
that,altered |
| R2551 |
T4597 |
T4594 |
ccomp |
altered,is |
| R2552 |
T4598 |
T4599 |
compound |
cathepsin,B |
| R2553 |
T4599 |
T4597 |
nsubjpass |
B,altered |
| R2554 |
T4600 |
T4599 |
cc |
and,B |
| R2555 |
T4601 |
T4602 |
det |
the,enzyme |
| R2556 |
T4602 |
T4599 |
conj |
enzyme,B |
| R2557 |
T4603 |
T4604 |
npadvmod |
CLN2,encoded |
| R2558 |
T4604 |
T4602 |
amod |
encoded,enzyme |
| R2559 |
T4605 |
T4604 |
punct |
-,encoded |
| R2560 |
T4606 |
T4602 |
punct |
", ",enzyme |
| R2561 |
T4607 |
T4602 |
appos |
TPPI,enzyme |
| R2562 |
T4608 |
T4597 |
punct |
", ",altered |
| R2563 |
T4609 |
T4597 |
auxpass |
are,altered |
| R2564 |
T4610 |
T4597 |
advmod |
also,altered |
| R2565 |
T4611 |
T4597 |
prep |
in,altered |
| R2566 |
T4612 |
T4611 |
pobj |
JNCL,in |
| R2567 |
T4613 |
T4614 |
punct |
[,18 |
| R2568 |
T4614 |
T4597 |
parataxis |
18,altered |
| R2569 |
T4615 |
T4616 |
punct |
-,20 |
| R2570 |
T4616 |
T4614 |
prep |
20,18 |
| R2571 |
T4617 |
T4614 |
punct |
],18 |
| R2572 |
T4618 |
T4594 |
punct |
.,is |
| R2573 |
T4620 |
T4621 |
advmod |
Nevertheless,appear |
| R2574 |
T4622 |
T4621 |
punct |
", ",appear |
| R2575 |
T4623 |
T4621 |
prep |
despite,appear |
| R2576 |
T4624 |
T4625 |
det |
the,alterations |
| R2577 |
T4625 |
T4623 |
pobj |
alterations,despite |
| R2578 |
T4626 |
T4627 |
compound |
cathepsin,D |
| R2579 |
T4627 |
T4625 |
compound |
D,alterations |
| R2580 |
T4628 |
T4625 |
compound |
protein,alterations |
| R2581 |
T4629 |
T4630 |
dep |
that,observed |
| R2582 |
T4630 |
T4625 |
relcl |
observed,alterations |
| R2583 |
T4631 |
T4630 |
auxpass |
are,observed |
| R2584 |
T4632 |
T4630 |
prep |
in,observed |
| R2585 |
T4633 |
T4634 |
amod |
homozygous,cells |
| R2586 |
T4634 |
T4632 |
pobj |
cells,in |
| R2587 |
T4635 |
T4634 |
nmod |
CbCln3Δex7,cells |
| R2588 |
T4636 |
T4635 |
punct |
/,CbCln3Δex7 |
| R2589 |
T4637 |
T4635 |
nummod |
8,CbCln3Δex7 |
| R2590 |
T4638 |
T4621 |
punct |
", ",appear |
| R2591 |
T4639 |
T4640 |
nmod |
cathepsin,D |
| R2592 |
T4640 |
T4641 |
nmod |
D,activity |
| R2593 |
T4641 |
T4621 |
nsubj |
activity,appear |
| R2594 |
T4642 |
T4641 |
amod |
enzymatic,activity |
| R2595 |
T4643 |
T4621 |
aux |
does,appear |
| R2596 |
T4644 |
T4621 |
neg |
not,appear |
| R2597 |
T4645 |
T4646 |
aux |
to,reduced |
| R2598 |
T4646 |
T4621 |
xcomp |
reduced,appear |
| R2599 |
T4647 |
T4646 |
auxpass |
be,reduced |
| R2600 |
T4648 |
T4621 |
punct |
.,appear |
| R2601 |
T4650 |
T4651 |
advmod |
Thus,is |
| R2602 |
T4652 |
T4651 |
punct |
", ",is |
| R2603 |
T4653 |
T4654 |
amod |
decreased,activity |
| R2604 |
T4654 |
T4651 |
nsubj |
activity,is |
| R2605 |
T4655 |
T4656 |
compound |
cathepsin,D |
| R2606 |
T4656 |
T4654 |
compound |
D,activity |
| R2607 |
T4657 |
T4651 |
acomp |
unlikely,is |
| R2608 |
T4658 |
T4659 |
aux |
to,account |
| R2609 |
T4659 |
T4657 |
xcomp |
account,unlikely |
| R2610 |
T4660 |
T4659 |
prep |
for,account |
| R2611 |
T4661 |
T4662 |
compound |
subunit,c |
| R2612 |
T4662 |
T4663 |
compound |
c,accumulation |
| R2613 |
T4663 |
T4660 |
pobj |
accumulation,for |
| R2614 |
T4664 |
T4659 |
prep |
in,account |
| R2615 |
T4665 |
T4664 |
pobj |
JNCL,in |
| R2616 |
T4666 |
T4651 |
punct |
.,is |
