Id |
Subject |
Object |
Predicate |
Lexical cue |
T194 |
0-4 |
NN |
denotes |
JNCL |
T195 |
5-7 |
VBZ |
denotes |
is |
T196 |
8-9 |
DT |
denotes |
a |
T198 |
10-21 |
RB |
denotes |
recessively |
T199 |
22-31 |
VBN |
denotes |
inherited |
T200 |
31-33 |
, |
denotes |
, |
T201 |
33-42 |
NN |
denotes |
childhood |
T203 |
42-43 |
HYPH |
denotes |
- |
T202 |
43-48 |
NN |
denotes |
onset |
T204 |
49-66 |
JJ |
denotes |
neurodegenerative |
T197 |
67-74 |
NN |
denotes |
disease |
T205 |
75-79 |
RBS |
denotes |
most |
T207 |
79-80 |
HYPH |
denotes |
- |
T206 |
80-88 |
RB |
denotes |
commonly |
T208 |
89-95 |
VBN |
denotes |
caused |
T209 |
96-98 |
IN |
denotes |
by |
T210 |
99-100 |
DT |
denotes |
a |
T212 |
101-102 |
SYM |
denotes |
~ |
T213 |
102-103 |
CD |
denotes |
1 |
T214 |
104-106 |
NN |
denotes |
kb |
T215 |
107-111 |
NN |
denotes |
CLN3 |
T211 |
112-120 |
NN |
denotes |
mutation |
T216 |
120-121 |
. |
denotes |
. |
T217 |
121-258 |
sentence |
denotes |
The resulting loss of battenin activity leads to deposition of mitochondrial ATP synthase, subunit c and a specific loss of CNS neurons. |
T218 |
122-125 |
DT |
denotes |
The |
T220 |
126-135 |
JJ |
denotes |
resulting |
T219 |
136-140 |
NN |
denotes |
loss |
T222 |
141-143 |
IN |
denotes |
of |
T223 |
144-152 |
NN |
denotes |
battenin |
T224 |
153-161 |
NN |
denotes |
activity |
T221 |
162-167 |
VBZ |
denotes |
leads |
T225 |
168-170 |
IN |
denotes |
to |
T226 |
171-181 |
NN |
denotes |
deposition |
T227 |
182-184 |
IN |
denotes |
of |
T228 |
185-198 |
JJ |
denotes |
mitochondrial |
T230 |
199-202 |
NN |
denotes |
ATP |
T229 |
203-211 |
NN |
denotes |
synthase |
T231 |
211-213 |
, |
denotes |
, |
T232 |
213-220 |
NN |
denotes |
subunit |
T233 |
221-222 |
NN |
denotes |
c |
T234 |
223-226 |
CC |
denotes |
and |
T235 |
227-228 |
DT |
denotes |
a |
T237 |
229-237 |
JJ |
denotes |
specific |
T236 |
238-242 |
NN |
denotes |
loss |
T238 |
243-245 |
IN |
denotes |
of |
T239 |
246-249 |
NN |
denotes |
CNS |
T240 |
250-257 |
NNS |
denotes |
neurons |
T241 |
257-258 |
. |
denotes |
. |
T242 |
258-407 |
sentence |
denotes |
We previously generated Cln3Δex7/8 knock-in mice, which replicate the common JNCL mutation, express mutant battenin and display JNCL-like pathology. |
T243 |
259-261 |
PRP |
denotes |
We |
T245 |
262-272 |
RB |
denotes |
previously |
T244 |
273-282 |
VBD |
denotes |
generated |
T246 |
283-291 |
NN |
denotes |
Cln3Δex7 |
T248 |
291-292 |
HYPH |
denotes |
/ |
T249 |
292-293 |
CD |
denotes |
8 |
T250 |
294-299 |
VB |
denotes |
knock |
T251 |
299-300 |
HYPH |
denotes |
- |
T252 |
300-302 |
RP |
denotes |
in |
T247 |
303-307 |
NNS |
denotes |
mice |
T253 |
307-309 |
, |
denotes |
, |
T254 |
309-314 |
WDT |
denotes |
which |
T255 |
315-324 |
VBP |
denotes |
replicate |
T256 |
325-328 |
DT |
denotes |
the |
T258 |
329-335 |
JJ |
denotes |
common |
T259 |
336-340 |
NN |
denotes |
JNCL |
T257 |
341-349 |
NN |
denotes |
mutation |
T260 |
349-351 |
, |
denotes |
, |
T261 |
351-358 |
VBP |
denotes |
express |
T262 |
359-365 |
NN |
denotes |
mutant |
T263 |
366-374 |
NN |
denotes |
battenin |
T264 |
375-378 |
CC |
denotes |
and |
T265 |
379-386 |
VBP |
denotes |
display |
T266 |
387-391 |
NN |
denotes |
JNCL |
T268 |
391-392 |
HYPH |
denotes |
- |
T267 |
392-396 |
JJ |
denotes |
like |
T269 |
397-406 |
NN |
denotes |
pathology |
T270 |
406-407 |
. |
denotes |
. |
R20 |
T194 |
T195 |
nsubj |
JNCL,is |
R21 |
T196 |
T197 |
det |
a,disease |
R22 |
T197 |
T195 |
attr |
disease,is |
R23 |
T198 |
T199 |
advmod |
recessively,inherited |
R24 |
T199 |
T197 |
amod |
inherited,disease |
R25 |
T200 |
T197 |
punct |
", ",disease |
R26 |
T201 |
T202 |
nmod |
childhood,onset |
R27 |
T202 |
T197 |
nmod |
onset,disease |
R28 |
T203 |
T202 |
punct |
-,onset |
R29 |
T204 |
T197 |
amod |
neurodegenerative,disease |
R30 |
T205 |
T206 |
advmod |
most,commonly |
R31 |
T206 |
T208 |
advmod |
commonly,caused |
R32 |
T207 |
T206 |
punct |
-,commonly |
R33 |
T208 |
T197 |
acl |
caused,disease |
R34 |
T209 |
T208 |
agent |
by,caused |
R35 |
T210 |
T211 |
det |
a,mutation |
R36 |
T211 |
T209 |
pobj |
mutation,by |
R37 |
T212 |
T213 |
punct |
~,1 |
R38 |
T213 |
T214 |
nummod |
1,kb |
R39 |
T214 |
T211 |
compound |
kb,mutation |
R40 |
T215 |
T211 |
compound |
CLN3,mutation |
R41 |
T216 |
T195 |
punct |
.,is |
R42 |
T218 |
T219 |
det |
The,loss |
R43 |
T219 |
T221 |
nsubj |
loss,leads |
R44 |
T220 |
T219 |
amod |
resulting,loss |
R45 |
T222 |
T219 |
prep |
of,loss |
R46 |
T223 |
T224 |
compound |
battenin,activity |
R47 |
T224 |
T222 |
pobj |
activity,of |
R48 |
T225 |
T221 |
prep |
to,leads |
R49 |
T226 |
T225 |
pobj |
deposition,to |
R50 |
T227 |
T226 |
prep |
of,deposition |
R51 |
T228 |
T229 |
amod |
mitochondrial,synthase |
R52 |
T229 |
T227 |
pobj |
synthase,of |
R53 |
T230 |
T229 |
compound |
ATP,synthase |
R54 |
T231 |
T229 |
punct |
", ",synthase |
R55 |
T232 |
T233 |
compound |
subunit,c |
R56 |
T233 |
T229 |
npadvmod |
c,synthase |
R57 |
T234 |
T226 |
cc |
and,deposition |
R58 |
T235 |
T236 |
det |
a,loss |
R59 |
T236 |
T226 |
conj |
loss,deposition |
R60 |
T237 |
T236 |
amod |
specific,loss |
R61 |
T238 |
T236 |
prep |
of,loss |
R62 |
T239 |
T240 |
compound |
CNS,neurons |
R63 |
T240 |
T238 |
pobj |
neurons,of |
R64 |
T241 |
T221 |
punct |
.,leads |
R65 |
T243 |
T244 |
nsubj |
We,generated |
R66 |
T245 |
T244 |
advmod |
previously,generated |
R67 |
T246 |
T247 |
nmod |
Cln3Δex7,mice |
R68 |
T247 |
T244 |
dobj |
mice,generated |
R69 |
T248 |
T246 |
punct |
/,Cln3Δex7 |
R70 |
T249 |
T246 |
nummod |
8,Cln3Δex7 |
R71 |
T250 |
T247 |
amod |
knock,mice |
R72 |
T251 |
T250 |
punct |
-,knock |
R73 |
T252 |
T250 |
prt |
in,knock |
R74 |
T253 |
T247 |
punct |
", ",mice |
R75 |
T254 |
T255 |
dep |
which,replicate |
R76 |
T255 |
T247 |
relcl |
replicate,mice |
R77 |
T256 |
T257 |
det |
the,mutation |
R78 |
T257 |
T255 |
dobj |
mutation,replicate |
R79 |
T258 |
T257 |
amod |
common,mutation |
R80 |
T259 |
T257 |
compound |
JNCL,mutation |
R81 |
T260 |
T255 |
punct |
", ",replicate |
R82 |
T261 |
T255 |
conj |
express,replicate |
R83 |
T262 |
T263 |
compound |
mutant,battenin |
R84 |
T263 |
T261 |
dobj |
battenin,express |
R85 |
T264 |
T261 |
cc |
and,express |
R86 |
T265 |
T261 |
conj |
display,express |
R87 |
T266 |
T267 |
npadvmod |
JNCL,like |
R88 |
T267 |
T269 |
amod |
like,pathology |
R89 |
T268 |
T267 |
punct |
-,like |
R90 |
T269 |
T265 |
dobj |
pathology,display |
R91 |
T270 |
T244 |
punct |
.,generated |