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PMC:539061 / 53646-54489 JSONTXT 5 Projects

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Id Subject Object Predicate Lexical cue
T11466 0-3 PRP$ denotes Our
T11468 4-6 NN denotes Tg
T11467 7-14 NNS denotes studies
T11469 15-24 VBD denotes suggested
T11470 25-29 IN denotes that
T11472 29-31 , denotes ,
T11473 31-33 RB denotes at
T11474 34-39 RBS denotes least
T11475 40-42 IN denotes in
T11477 43-47 NN denotes part
T11476 48-55 IN denotes through
T11478 56-59 PRP$ denotes its
T11479 60-70 NN denotes regulation
T11480 71-73 IN denotes of
T11481 74-75 NN denotes E
T11483 75-76 HYPH denotes -
T11482 76-84 NN denotes cadherin
T11484 84-86 , denotes ,
T11485 86-91 NN denotes Snail
T11471 92-94 VBZ denotes is
T11486 95-99 JJ denotes able
T11487 100-102 TO denotes to
T11488 103-112 VB denotes influence
T11489 113-116 DT denotes the
T11491 117-128 JJ denotes subcellular
T11490 129-141 NN denotes localization
T11492 142-144 IN denotes of
T11493 145-146 DT denotes a
T11494 147-154 NN denotes variety
T11495 155-157 IN denotes of
T11496 158-160 NN denotes AJ
T11498 160-161 HYPH denotes -
T11497 161-171 VBN denotes associated
T11499 172-180 NN denotes proteins
T11500 180-181 . denotes .
T11501 181-311 sentence denotes One of these appears to be Ajuba, which was previously shown to have the dual capacity to bind Grb-2 as well as α-catenin [9,10].
T11502 182-185 CD denotes One
T11504 186-188 IN denotes of
T11505 189-194 DT denotes these
T11503 195-202 VBZ denotes appears
T11506 203-205 TO denotes to
T11507 206-208 VB denotes be
T11508 209-214 NN denotes Ajuba
T11509 214-216 , denotes ,
T11510 216-221 WDT denotes which
T11512 222-225 VBD denotes was
T11513 226-236 RB denotes previously
T11511 237-242 VBN denotes shown
T11514 243-245 TO denotes to
T11515 246-250 VB denotes have
T11516 251-254 DT denotes the
T11518 255-259 JJ denotes dual
T11517 260-268 NN denotes capacity
T11519 269-271 TO denotes to
T11520 272-276 VB denotes bind
T11521 277-280 NN denotes Grb
T11522 280-281 HYPH denotes -
T11523 281-282 CD denotes 2
T11524 283-285 RB denotes as
T11526 286-290 RB denotes well
T11525 291-293 IN denotes as
T11527 294-295 NN denotes α
T11529 295-296 HYPH denotes -
T11528 296-303 NN denotes catenin
T11530 304-305 -LRB- denotes [
T11532 305-306 CD denotes 9
T11533 306-307 , denotes ,
T11531 307-309 CD denotes 10
T11534 309-310 -RRB- denotes ]
T11535 310-311 . denotes .
T11536 311-539 sentence denotes Our studies revealed that in skin keratinocytes that either harbor a conditional null mutation in α-catenin or that overexpress Snail, Ajuba develops an interaction with Grb-2 that is otherwise not observed in WT keratinocytes.
T11537 312-315 PRP$ denotes Our
T11538 316-323 NNS denotes studies
T11539 324-332 VBD denotes revealed
T11540 333-337 IN denotes that
T11542 338-340 IN denotes in
T11543 341-345 NN denotes skin
T11544 346-359 NNS denotes keratinocytes
T11545 360-364 WDT denotes that
T11547 365-371 CC denotes either
T11546 372-378 VBP denotes harbor
T11548 379-380 DT denotes a
T11550 381-392 JJ denotes conditional
T11551 393-397 JJ denotes null
T11549 398-406 NN denotes mutation
T11552 407-409 IN denotes in
T11553 410-411 NN denotes α
T11555 411-412 HYPH denotes -
T11554 412-419 NN denotes catenin
T11556 420-422 CC denotes or
T11557 423-427 WDT denotes that
T11558 428-439 VBP denotes overexpress
T11559 440-445 NN denotes Snail
T11560 445-447 , denotes ,
T11561 447-452 NN denotes Ajuba
T11541 453-461 VBZ denotes develops
T11562 462-464 DT denotes an
T11563 465-476 NN denotes interaction
T11564 477-481 IN denotes with
T11565 482-485 NN denotes Grb
T11566 485-486 HYPH denotes -
T11567 486-487 CD denotes 2
T11568 488-492 WDT denotes that
T11570 493-495 VBZ denotes is
T11571 496-505 RB denotes otherwise
T11572 506-509 RB denotes not
T11569 510-518 VBN denotes observed
T11573 519-521 IN denotes in
T11574 522-524 NN denotes WT
T11575 525-538 NNS denotes keratinocytes
T11576 538-539 . denotes .
T11577 539-843 sentence denotes The corresponding abilities of either Snail-transfected or Ajuba-transfected keratinocytes to exhibit elevated activation of the Ras-MAPK pathway suggest that the Grb-2 association of Ajuba under conditions of reduced levels of AJ proteins may be directly relevant to the parallel in hyperproliferation.
T11578 540-543 DT denotes The
T11580 544-557 VBG denotes corresponding
T11579 558-567 NNS denotes abilities
T11582 568-570 IN denotes of
T11583 571-577 CC denotes either
T11585 578-583 NN denotes Snail
T11587 583-584 HYPH denotes -
T11586 584-595 VBN denotes transfected
T11588 596-598 CC denotes or
T11589 599-604 NN denotes Ajuba
T11591 604-605 HYPH denotes -
T11590 605-616 VBN denotes transfected
T11584 617-630 NNS denotes keratinocytes
T11592 631-633 TO denotes to
T11593 634-641 VB denotes exhibit
T11594 642-650 JJ denotes elevated
T11595 651-661 NN denotes activation
T11596 662-664 IN denotes of
T11597 665-668 DT denotes the
T11599 669-672 NN denotes Ras
T11601 672-673 HYPH denotes -
T11600 673-677 NN denotes MAPK
T11598 678-685 NN denotes pathway
T11581 686-693 VBP denotes suggest
T11602 694-698 IN denotes that
T11604 699-702 DT denotes the
T11606 703-706 NN denotes Grb
T11607 706-707 HYPH denotes -
T11608 707-708 CD denotes 2
T11605 709-720 NN denotes association
T11609 721-723 IN denotes of
T11610 724-729 NN denotes Ajuba
T11611 730-735 IN denotes under
T11612 736-746 NNS denotes conditions
T11613 747-749 IN denotes of
T11614 750-757 JJ denotes reduced
T11615 758-764 NNS denotes levels
T11616 765-767 IN denotes of
T11617 768-770 NN denotes AJ
T11618 771-779 NN denotes proteins
T11619 780-783 MD denotes may
T11603 784-786 VB denotes be
T11620 787-795 RB denotes directly
T11621 796-804 JJ denotes relevant
T11622 805-807 IN denotes to
T11623 808-811 DT denotes the
T11624 812-820 NN denotes parallel
T11625 821-823 IN denotes in
T11626 824-842 NN denotes hyperproliferation
T11627 842-843 . denotes .
R7263 T11466 T11467 poss Our,studies
R7264 T11467 T11469 nsubj studies,suggested
R7265 T11468 T11467 compound Tg,studies
R7266 T11470 T11471 mark that,is
R7267 T11471 T11469 ccomp is,suggested
R7268 T11472 T11471 punct ", ",is
R7269 T11473 T11474 advmod at,least
R7270 T11474 T11475 advmod least,in
R7271 T11475 T11476 prep in,through
R7272 T11476 T11471 prep through,is
R7273 T11477 T11475 pobj part,in
R7274 T11478 T11479 poss its,regulation
R7275 T11479 T11476 pobj regulation,through
R7276 T11480 T11479 prep of,regulation
R7277 T11481 T11482 compound E,cadherin
R7278 T11482 T11480 pobj cadherin,of
R7279 T11483 T11482 punct -,cadherin
R7280 T11484 T11471 punct ", ",is
R7281 T11485 T11471 nsubj Snail,is
R7282 T11486 T11471 acomp able,is
R7283 T11487 T11488 aux to,influence
R7284 T11488 T11486 xcomp influence,able
R7285 T11489 T11490 det the,localization
R7286 T11490 T11488 dobj localization,influence
R7287 T11491 T11490 amod subcellular,localization
R7288 T11492 T11490 prep of,localization
R7289 T11493 T11494 det a,variety
R7290 T11494 T11492 pobj variety,of
R7291 T11495 T11494 prep of,variety
R7292 T11496 T11497 npadvmod AJ,associated
R7293 T11497 T11499 amod associated,proteins
R7294 T11498 T11497 punct -,associated
R7295 T11499 T11495 pobj proteins,of
R7296 T11500 T11469 punct .,suggested
R7297 T11502 T11503 nsubj One,appears
R7298 T11504 T11502 prep of,One
R7299 T11505 T11504 pobj these,of
R7300 T11506 T11507 aux to,be
R7301 T11507 T11503 xcomp be,appears
R7302 T11508 T11507 attr Ajuba,be
R7303 T11509 T11508 punct ", ",Ajuba
R7304 T11510 T11511 dep which,shown
R7305 T11511 T11508 relcl shown,Ajuba
R7306 T11512 T11511 auxpass was,shown
R7307 T11513 T11511 advmod previously,shown
R7308 T11514 T11515 aux to,have
R7309 T11515 T11511 xcomp have,shown
R7310 T11516 T11517 det the,capacity
R7311 T11517 T11515 dobj capacity,have
R7312 T11518 T11517 amod dual,capacity
R7313 T11519 T11520 aux to,bind
R7314 T11520 T11517 acl bind,capacity
R7315 T11521 T11520 dobj Grb,bind
R7316 T11522 T11521 punct -,Grb
R7317 T11523 T11521 nummod 2,Grb
R7318 T11524 T11525 advmod as,as
R7319 T11525 T11521 cc as,Grb
R7320 T11526 T11525 advmod well,as
R7321 T11527 T11528 compound α,catenin
R7322 T11528 T11521 conj catenin,Grb
R7323 T11529 T11528 punct -,catenin
R7324 T11530 T11531 punct [,10
R7325 T11531 T11503 parataxis 10,appears
R7326 T11532 T11531 nummod 9,10
R7327 T11533 T11531 punct ",",10
R7328 T11534 T11531 punct ],10
R7329 T11535 T11503 punct .,appears
R7330 T11537 T11538 poss Our,studies
R7331 T11538 T11539 nsubj studies,revealed
R7332 T11540 T11541 mark that,develops
R7333 T11541 T11539 ccomp develops,revealed
R7334 T11542 T11541 prep in,develops
R7335 T11543 T11544 compound skin,keratinocytes
R7336 T11544 T11542 pobj keratinocytes,in
R7337 T11545 T11546 dep that,harbor
R7338 T11546 T11544 advcl harbor,keratinocytes
R7339 T11547 T11546 preconj either,harbor
R7340 T11548 T11549 det a,mutation
R7341 T11549 T11546 dobj mutation,harbor
R7342 T11550 T11549 amod conditional,mutation
R7343 T11551 T11549 amod null,mutation
R7344 T11552 T11546 prep in,harbor
R7345 T11553 T11554 compound α,catenin
R7346 T11554 T11552 pobj catenin,in
R7347 T11555 T11554 punct -,catenin
R7348 T11556 T11546 cc or,harbor
R7349 T11557 T11558 dep that,overexpress
R7350 T11558 T11546 conj overexpress,harbor
R7351 T11559 T11558 dobj Snail,overexpress
R7352 T11560 T11541 punct ", ",develops
R7353 T11561 T11541 nsubj Ajuba,develops
R7354 T11562 T11563 det an,interaction
R7355 T11563 T11541 dobj interaction,develops
R7356 T11564 T11563 prep with,interaction
R7357 T11565 T11564 pobj Grb,with
R7358 T11566 T11565 punct -,Grb
R7359 T11567 T11565 nummod 2,Grb
R7360 T11568 T11569 dep that,observed
R7361 T11569 T11563 relcl observed,interaction
R7362 T11570 T11569 auxpass is,observed
R7363 T11571 T11569 advmod otherwise,observed
R7364 T11572 T11569 neg not,observed
R7365 T11573 T11569 prep in,observed
R7366 T11574 T11575 compound WT,keratinocytes
R7367 T11575 T11573 pobj keratinocytes,in
R7368 T11576 T11539 punct .,revealed
R7369 T11578 T11579 det The,abilities
R7370 T11579 T11581 nsubj abilities,suggest
R7371 T11580 T11579 amod corresponding,abilities
R7372 T11582 T11579 prep of,abilities
R7373 T11583 T11584 preconj either,keratinocytes
R7374 T11584 T11582 pobj keratinocytes,of
R7375 T11585 T11586 npadvmod Snail,transfected
R7376 T11586 T11584 amod transfected,keratinocytes
R7377 T11587 T11586 punct -,transfected
R7378 T11588 T11586 cc or,transfected
R7379 T11589 T11590 npadvmod Ajuba,transfected
R7380 T11590 T11586 conj transfected,transfected
R7381 T11591 T11590 punct -,transfected
R7382 T11592 T11593 aux to,exhibit
R7383 T11593 T11579 acl exhibit,abilities
R7384 T11594 T11595 amod elevated,activation
R7385 T11595 T11593 dobj activation,exhibit
R7386 T11596 T11595 prep of,activation
R7387 T11597 T11598 det the,pathway
R7388 T11598 T11596 pobj pathway,of
R7389 T11599 T11600 compound Ras,MAPK
R7390 T11600 T11598 compound MAPK,pathway
R7391 T11601 T11600 punct -,MAPK
R7392 T11602 T11603 mark that,be
R7393 T11603 T11581 ccomp be,suggest
R7394 T11604 T11605 det the,association
R7395 T11605 T11603 nsubj association,be
R7396 T11606 T11605 nmod Grb,association
R7397 T11607 T11606 punct -,Grb
R7398 T11608 T11606 nummod 2,Grb
R7399 T11609 T11605 prep of,association
R7400 T11610 T11609 pobj Ajuba,of
R7401 T11611 T11603 prep under,be
R7402 T11612 T11611 pobj conditions,under
R7403 T11613 T11612 prep of,conditions
R7404 T11614 T11615 amod reduced,levels
R7405 T11615 T11613 pobj levels,of
R7406 T11616 T11615 prep of,levels
R7407 T11617 T11618 compound AJ,proteins
R7408 T11618 T11616 pobj proteins,of
R7409 T11619 T11603 aux may,be
R7410 T11620 T11621 advmod directly,relevant
R7411 T11621 T11603 acomp relevant,be
R7412 T11622 T11621 prep to,relevant
R7413 T11623 T11624 det the,parallel
R7414 T11624 T11622 pobj parallel,to
R7415 T11625 T11624 prep in,parallel
R7416 T11626 T11625 pobj hyperproliferation,in
R7417 T11627 T11581 punct .,suggest