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PMC:539061 / 50388-51521 JSONTXT 4 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T10471 0-2 IN denotes At
T10473 3-8 JJ denotes first
T10474 9-15 NN denotes glance
T10475 15-17 , denotes ,
T10476 17-20 DT denotes the
T10477 21-29 NN denotes sparsity
T10478 30-32 IN denotes in
T10479 33-37 NN denotes hair
T10480 38-42 NN denotes coat
T10481 43-45 IN denotes of
T10482 46-49 NN denotes K14
T10484 49-50 HYPH denotes -
T10483 50-55 NN denotes Snail
T10486 56-58 NN denotes Tg
T10485 59-63 NNS denotes mice
T10472 64-70 VBD denotes seemed
T10487 71-81 JJ denotes indicative
T10488 82-84 IN denotes of
T10489 85-86 DT denotes a
T10490 87-93 NN denotes defect
T10491 94-96 IN denotes in
T10492 97-105 NN denotes follicle
T10493 106-115 NN denotes formation
T10494 116-117 -LRB- denotes (
T10495 117-120 VB denotes see
T10496 121-127 NN denotes Figure
T10497 128-130 NN denotes 2A
T10498 130-131 -RRB- denotes )
T10499 131-132 . denotes .
T10500 132-232 sentence denotes Closer inspection, however, revealed that not all hairs penetrated the hyperthickened Tg epidermis.
T10501 133-139 JJR denotes Closer
T10502 140-150 NN denotes inspection
T10504 150-152 , denotes ,
T10505 152-159 RB denotes however
T10506 159-161 , denotes ,
T10503 161-169 VBD denotes revealed
T10507 170-174 IN denotes that
T10509 175-178 RB denotes not
T10511 179-182 DT denotes all
T10510 183-188 NNS denotes hairs
T10508 189-199 VBD denotes penetrated
T10512 200-203 DT denotes the
T10514 204-218 VBN denotes hyperthickened
T10515 219-221 NN denotes Tg
T10513 222-231 NN denotes epidermis
T10516 231-232 . denotes .
T10517 232-323 sentence denotes Several factors may contribute to the seemingly normal follicle development in these mice.
T10518 233-240 JJ denotes Several
T10519 241-248 NNS denotes factors
T10521 249-252 MD denotes may
T10520 253-263 VB denotes contribute
T10522 264-266 IN denotes to
T10523 267-270 DT denotes the
T10525 271-280 RB denotes seemingly
T10526 281-287 JJ denotes normal
T10527 288-296 NN denotes follicle
T10524 297-308 NN denotes development
T10528 309-311 IN denotes in
T10529 312-317 DT denotes these
T10530 318-322 NNS denotes mice
T10531 322-323 . denotes .
T10532 323-587 sentence denotes One obvious factor is the K14 promoter, which is elevated in the basal layer of the epidermis and the outer root sheath (ORS) of the hair follicle, but is markedly down-regulated in developing embryonic hair buds as well as in the postnatal hair progenitor cells.
T10533 324-327 CD denotes One
T10535 328-335 JJ denotes obvious
T10534 336-342 NN denotes factor
T10536 343-345 VBZ denotes is
T10537 346-349 DT denotes the
T10539 350-353 NN denotes K14
T10538 354-362 NN denotes promoter
T10540 362-364 , denotes ,
T10541 364-369 WDT denotes which
T10542 370-372 VBZ denotes is
T10543 373-381 JJ denotes elevated
T10544 382-384 IN denotes in
T10545 385-388 DT denotes the
T10547 389-394 JJ denotes basal
T10546 395-400 NN denotes layer
T10548 401-403 IN denotes of
T10549 404-407 DT denotes the
T10550 408-417 NN denotes epidermis
T10551 418-421 CC denotes and
T10552 422-425 DT denotes the
T10554 426-431 JJ denotes outer
T10555 432-436 NN denotes root
T10553 437-443 NN denotes sheath
T10556 444-445 -LRB- denotes (
T10557 445-448 NN denotes ORS
T10558 448-449 -RRB- denotes )
T10559 450-452 IN denotes of
T10560 453-456 DT denotes the
T10562 457-461 NN denotes hair
T10561 462-470 NN denotes follicle
T10563 470-472 , denotes ,
T10564 472-475 CC denotes but
T10565 476-478 VBZ denotes is
T10567 479-487 RB denotes markedly
T10568 488-492 RB denotes down
T10569 492-493 HYPH denotes -
T10566 493-502 VBN denotes regulated
T10570 503-505 IN denotes in
T10571 506-516 JJ denotes developing
T10573 517-526 JJ denotes embryonic
T10574 527-531 NN denotes hair
T10572 532-536 NNS denotes buds
T10575 537-539 RB denotes as
T10577 540-544 RB denotes well
T10576 545-547 IN denotes as
T10578 548-550 IN denotes in
T10579 551-554 DT denotes the
T10581 555-564 JJ denotes postnatal
T10582 565-569 NN denotes hair
T10583 570-580 NN denotes progenitor
T10580 581-586 NNS denotes cells
T10584 586-587 . denotes .
T10585 587-747 sentence denotes The K14 promoter is also less active in the ORS than epidermis and hence this might also account for the lack of apparent response of the ORS to ectopic Snail.
T10586 588-591 DT denotes The
T10588 592-595 NN denotes K14
T10587 596-604 NN denotes promoter
T10589 605-607 VBZ denotes is
T10590 608-612 RB denotes also
T10591 613-617 RBR denotes less
T10592 618-624 JJ denotes active
T10593 625-627 IN denotes in
T10594 628-631 DT denotes the
T10595 632-635 NN denotes ORS
T10596 636-640 IN denotes than
T10597 641-650 NN denotes epidermis
T10598 651-654 CC denotes and
T10599 655-660 RB denotes hence
T10601 661-665 DT denotes this
T10602 666-671 MD denotes might
T10603 672-676 RB denotes also
T10600 677-684 VB denotes account
T10604 685-688 IN denotes for
T10605 689-692 DT denotes the
T10606 693-697 NN denotes lack
T10607 698-700 IN denotes of
T10608 701-709 JJ denotes apparent
T10609 710-718 NN denotes response
T10610 719-721 IN denotes of
T10611 722-725 DT denotes the
T10612 726-729 NN denotes ORS
T10613 730-732 IN denotes to
T10614 733-740 JJ denotes ectopic
T10615 741-746 NN denotes Snail
T10616 746-747 . denotes .
T10617 747-998 sentence denotes Additional contributing factors could be the multiplicity of Snail family members and their differential expression, the saturation, and/or diversity of regulatory mechanisms that govern AJ formation, migration, and proliferation in the follicle ORS.
T10618 748-758 JJ denotes Additional
T10620 759-771 VBG denotes contributing
T10619 772-779 NNS denotes factors
T10622 780-785 MD denotes could
T10621 786-788 VB denotes be
T10623 789-792 DT denotes the
T10624 793-805 NN denotes multiplicity
T10625 806-808 IN denotes of
T10626 809-814 NN denotes Snail
T10628 815-821 NN denotes family
T10627 822-829 NNS denotes members
T10629 830-833 CC denotes and
T10630 834-839 PRP$ denotes their
T10632 840-852 JJ denotes differential
T10631 853-863 NN denotes expression
T10633 863-865 , denotes ,
T10634 865-868 DT denotes the
T10635 869-879 NN denotes saturation
T10636 879-881 , denotes ,
T10637 881-884 CC denotes and
T10638 884-885 HYPH denotes /
T10639 885-887 CC denotes or
T10640 888-897 NN denotes diversity
T10641 898-900 IN denotes of
T10642 901-911 JJ denotes regulatory
T10643 912-922 NNS denotes mechanisms
T10644 923-927 WDT denotes that
T10645 928-934 VBP denotes govern
T10646 935-937 NN denotes AJ
T10647 938-947 NN denotes formation
T10648 947-949 , denotes ,
T10649 949-958 NN denotes migration
T10650 958-960 , denotes ,
T10651 960-963 CC denotes and
T10652 964-977 NN denotes proliferation
T10653 978-980 IN denotes in
T10654 981-984 DT denotes the
T10656 985-993 NN denotes follicle
T10655 994-997 NN denotes ORS
T10657 997-998 . denotes .
T10658 998-1133 sentence denotes Distinguishing between these possibilities must await the generation of mice harboring skin-specific loss-of-function Snail mutations.
T10659 999-1013 VBG denotes Distinguishing
T10661 1014-1021 IN denotes between
T10662 1022-1027 DT denotes these
T10663 1028-1041 NNS denotes possibilities
T10664 1042-1046 MD denotes must
T10660 1047-1052 VB denotes await
T10665 1053-1056 DT denotes the
T10666 1057-1067 NN denotes generation
T10667 1068-1070 IN denotes of
T10668 1071-1075 NNS denotes mice
T10669 1076-1085 VBG denotes harboring
T10670 1086-1090 NN denotes skin
T10672 1090-1091 HYPH denotes -
T10671 1091-1099 JJ denotes specific
T10674 1100-1104 NN denotes loss
T10675 1104-1105 HYPH denotes -
T10676 1105-1107 IN denotes of
T10677 1107-1108 HYPH denotes -
T10678 1108-1116 NN denotes function
T10679 1117-1122 NN denotes Snail
T10673 1123-1132 NNS denotes mutations
T10680 1132-1133 . denotes .
R6671 T10471 T10472 prep At,seemed
R6672 T10473 T10474 amod first,glance
R6673 T10474 T10471 pobj glance,At
R6674 T10475 T10472 punct ", ",seemed
R6675 T10476 T10477 det the,sparsity
R6676 T10477 T10472 nsubj sparsity,seemed
R6677 T10478 T10477 prep in,sparsity
R6678 T10479 T10480 compound hair,coat
R6679 T10480 T10478 pobj coat,in
R6680 T10481 T10480 prep of,coat
R6681 T10482 T10483 compound K14,Snail
R6682 T10483 T10485 compound Snail,mice
R6683 T10484 T10483 punct -,Snail
R6684 T10485 T10481 pobj mice,of
R6685 T10486 T10485 compound Tg,mice
R6686 T10487 T10472 oprd indicative,seemed
R6687 T10488 T10487 prep of,indicative
R6688 T10489 T10490 det a,defect
R6689 T10490 T10488 pobj defect,of
R6690 T10491 T10490 prep in,defect
R6691 T10492 T10493 compound follicle,formation
R6692 T10493 T10491 pobj formation,in
R6693 T10494 T10495 punct (,see
R6694 T10495 T10472 parataxis see,seemed
R6695 T10496 T10497 compound Figure,2A
R6696 T10497 T10495 dobj 2A,see
R6697 T10498 T10495 punct ),see
R6698 T10499 T10472 punct .,seemed
R6699 T10501 T10502 amod Closer,inspection
R6700 T10502 T10503 nsubj inspection,revealed
R6701 T10504 T10503 punct ", ",revealed
R6702 T10505 T10503 advmod however,revealed
R6703 T10506 T10503 punct ", ",revealed
R6704 T10507 T10508 mark that,penetrated
R6705 T10508 T10503 ccomp penetrated,revealed
R6706 T10509 T10510 neg not,hairs
R6707 T10510 T10508 nsubj hairs,penetrated
R6708 T10511 T10510 det all,hairs
R6709 T10512 T10513 det the,epidermis
R6710 T10513 T10508 dobj epidermis,penetrated
R6711 T10514 T10513 amod hyperthickened,epidermis
R6712 T10515 T10513 compound Tg,epidermis
R6713 T10516 T10503 punct .,revealed
R6714 T10518 T10519 amod Several,factors
R6715 T10519 T10520 nsubj factors,contribute
R6716 T10521 T10520 aux may,contribute
R6717 T10522 T10520 prep to,contribute
R6718 T10523 T10524 det the,development
R6719 T10524 T10522 pobj development,to
R6720 T10525 T10526 advmod seemingly,normal
R6721 T10526 T10524 amod normal,development
R6722 T10527 T10524 compound follicle,development
R6723 T10528 T10524 prep in,development
R6724 T10529 T10530 det these,mice
R6725 T10530 T10528 pobj mice,in
R6726 T10531 T10520 punct .,contribute
R6727 T10533 T10534 nummod One,factor
R6728 T10534 T10536 nsubj factor,is
R6729 T10535 T10534 amod obvious,factor
R6730 T10537 T10538 det the,promoter
R6731 T10538 T10536 attr promoter,is
R6732 T10539 T10538 compound K14,promoter
R6733 T10540 T10538 punct ", ",promoter
R6734 T10541 T10542 dep which,is
R6735 T10542 T10538 relcl is,promoter
R6736 T10543 T10542 acomp elevated,is
R6737 T10544 T10542 prep in,is
R6738 T10545 T10546 det the,layer
R6739 T10546 T10544 pobj layer,in
R6740 T10547 T10546 amod basal,layer
R6741 T10548 T10546 prep of,layer
R6742 T10549 T10550 det the,epidermis
R6743 T10550 T10548 pobj epidermis,of
R6744 T10551 T10546 cc and,layer
R6745 T10552 T10553 det the,sheath
R6746 T10553 T10546 conj sheath,layer
R6747 T10554 T10553 amod outer,sheath
R6748 T10555 T10553 compound root,sheath
R6749 T10556 T10553 punct (,sheath
R6750 T10557 T10553 appos ORS,sheath
R6751 T10558 T10553 punct ),sheath
R6752 T10559 T10553 prep of,sheath
R6753 T10560 T10561 det the,follicle
R6754 T10561 T10559 pobj follicle,of
R6755 T10562 T10561 compound hair,follicle
R6756 T10563 T10536 punct ", ",is
R6757 T10564 T10536 cc but,is
R6758 T10565 T10566 auxpass is,regulated
R6759 T10566 T10536 conj regulated,is
R6760 T10567 T10566 advmod markedly,regulated
R6761 T10568 T10566 advmod down,regulated
R6762 T10569 T10566 punct -,regulated
R6763 T10570 T10566 prep in,regulated
R6764 T10571 T10572 amod developing,buds
R6765 T10572 T10570 pobj buds,in
R6766 T10573 T10572 amod embryonic,buds
R6767 T10574 T10572 compound hair,buds
R6768 T10575 T10576 advmod as,as
R6769 T10576 T10570 cc as,in
R6770 T10577 T10576 advmod well,as
R6771 T10578 T10570 conj in,in
R6772 T10579 T10580 det the,cells
R6773 T10580 T10578 pobj cells,in
R6774 T10581 T10580 amod postnatal,cells
R6775 T10582 T10580 compound hair,cells
R6776 T10583 T10580 compound progenitor,cells
R6777 T10584 T10536 punct .,is
R6778 T10586 T10587 det The,promoter
R6779 T10587 T10589 nsubj promoter,is
R6780 T10588 T10587 compound K14,promoter
R6781 T10590 T10589 advmod also,is
R6782 T10591 T10592 advmod less,active
R6783 T10592 T10589 acomp active,is
R6784 T10593 T10592 prep in,active
R6785 T10594 T10595 det the,ORS
R6786 T10595 T10593 pobj ORS,in
R6787 T10596 T10592 prep than,active
R6788 T10597 T10596 pcomp epidermis,than
R6789 T10598 T10589 cc and,is
R6790 T10599 T10600 advmod hence,account
R6791 T10600 T10589 conj account,is
R6792 T10601 T10600 nsubj this,account
R6793 T10602 T10600 aux might,account
R6794 T10603 T10600 advmod also,account
R6795 T10604 T10600 prep for,account
R6796 T10605 T10606 det the,lack
R6797 T10606 T10604 pobj lack,for
R6798 T10607 T10606 prep of,lack
R6799 T10608 T10609 amod apparent,response
R6800 T10609 T10607 pobj response,of
R6801 T10610 T10609 prep of,response
R6802 T10611 T10612 det the,ORS
R6803 T10612 T10610 pobj ORS,of
R6804 T10613 T10609 prep to,response
R6805 T10614 T10615 amod ectopic,Snail
R6806 T10615 T10613 pobj Snail,to
R6807 T10616 T10600 punct .,account
R6808 T10618 T10619 amod Additional,factors
R6809 T10619 T10621 nsubj factors,be
R6810 T10620 T10619 amod contributing,factors
R6811 T10622 T10621 aux could,be
R6812 T10623 T10624 det the,multiplicity
R6813 T10624 T10621 attr multiplicity,be
R6814 T10625 T10624 prep of,multiplicity
R6815 T10626 T10627 compound Snail,members
R6816 T10627 T10625 pobj members,of
R6817 T10628 T10627 compound family,members
R6818 T10629 T10627 cc and,members
R6819 T10630 T10631 poss their,expression
R6820 T10631 T10627 conj expression,members
R6821 T10632 T10631 amod differential,expression
R6822 T10633 T10627 punct ", ",members
R6823 T10634 T10635 det the,saturation
R6824 T10635 T10627 appos saturation,members
R6825 T10636 T10635 punct ", ",saturation
R6826 T10637 T10635 cc and,saturation
R6827 T10638 T10637 punct /,and
R6828 T10639 T10637 cc or,and
R6829 T10640 T10635 conj diversity,saturation
R6830 T10641 T10635 prep of,saturation
R6831 T10642 T10643 amod regulatory,mechanisms
R6832 T10643 T10641 pobj mechanisms,of
R6833 T10644 T10645 dep that,govern
R6834 T10645 T10643 relcl govern,mechanisms
R6835 T10646 T10647 compound AJ,formation
R6836 T10647 T10645 dobj formation,govern
R6837 T10648 T10647 punct ", ",formation
R6838 T10649 T10647 conj migration,formation
R6839 T10650 T10649 punct ", ",migration
R6840 T10651 T10649 cc and,migration
R6841 T10652 T10649 conj proliferation,migration
R6842 T10653 T10645 prep in,govern
R6843 T10654 T10655 det the,ORS
R6844 T10655 T10653 pobj ORS,in
R6845 T10656 T10655 compound follicle,ORS
R6846 T10657 T10621 punct .,be
R6847 T10659 T10660 csubj Distinguishing,await
R6848 T10661 T10659 prep between,Distinguishing
R6849 T10662 T10663 det these,possibilities
R6850 T10663 T10661 pobj possibilities,between
R6851 T10664 T10660 aux must,await
R6852 T10665 T10666 det the,generation
R6853 T10666 T10660 dobj generation,await
R6854 T10667 T10666 prep of,generation
R6855 T10668 T10667 pobj mice,of
R6856 T10669 T10668 acl harboring,mice
R6857 T10670 T10671 npadvmod skin,specific
R6858 T10671 T10673 amod specific,mutations
R6859 T10672 T10671 punct -,specific
R6860 T10673 T10669 dobj mutations,harboring
R6861 T10674 T10673 nmod loss,mutations
R6862 T10675 T10674 punct -,loss
R6863 T10676 T10674 prep of,loss
R6864 T10677 T10676 punct -,of
R6865 T10678 T10676 pobj function,of
R6866 T10679 T10673 compound Snail,mutations
R6867 T10680 T10660 punct .,await