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PMC:539061 / 49297-50387 JSONTXT 5 Projects

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Id Subject Object Predicate Lexical cue
T10280 0-3 DT denotes The
T10282 4-9 JJ denotes prior
T10281 10-24 NN denotes identification
T10284 25-27 IN denotes of
T10285 28-31 DT denotes the
T10287 32-37 NN denotes Snail
T10286 38-42 NN denotes gene
T10288 43-45 IN denotes as
T10289 46-47 DT denotes a
T10291 48-57 JJ denotes potential
T10290 58-64 NN denotes target
T10292 65-67 IN denotes of
T10293 68-71 NN denotes TGF
T10295 71-72 HYPH denotes -
T10294 72-73 NN denotes β
T10296 74-83 NN denotes signaling
T10297 84-85 -LRB- denotes [
T10298 85-87 CD denotes 15
T10299 87-88 -RRB- denotes ]
T10283 89-92 VBD denotes was
T10300 93-103 JJ denotes intriguing
T10301 103-105 , denotes ,
T10302 105-110 VBN denotes given
T10303 111-114 DT denotes the
T10305 115-123 JJ denotes temporal
T10304 124-128 NN denotes wave
T10306 129-131 IN denotes of
T10307 132-137 NN denotes Snail
T10309 138-142 NN denotes gene
T10308 143-153 NN denotes expression
T10310 154-158 WDT denotes that
T10311 159-165 VBZ denotes occurs
T10312 166-168 IN denotes in
T10313 169-172 DT denotes the
T10315 173-183 VBG denotes developing
T10316 184-188 NN denotes hair
T10314 189-192 NN denotes bud
T10317 192-193 . denotes .
T10318 193-364 sentence denotes The additional correlation between epithelial hyperproliferation and Snail transgene expression further fostered our interest in a possible link between TGF-β2 and Snail.
T10319 194-197 DT denotes The
T10321 198-208 JJ denotes additional
T10320 209-220 NN denotes correlation
T10323 221-228 IN denotes between
T10324 229-239 JJ denotes epithelial
T10325 240-258 NN denotes hyperproliferation
T10326 259-262 CC denotes and
T10327 263-268 NN denotes Snail
T10329 269-278 NN denotes transgene
T10328 279-289 NN denotes expression
T10330 290-297 RB denotes further
T10322 298-306 VBD denotes fostered
T10331 307-310 PRP$ denotes our
T10332 311-319 NN denotes interest
T10333 320-322 IN denotes in
T10334 323-324 DT denotes a
T10336 325-333 JJ denotes possible
T10335 334-338 NN denotes link
T10337 339-346 IN denotes between
T10338 347-350 NN denotes TGF
T10340 350-351 HYPH denotes -
T10339 351-353 NN denotes β2
T10341 354-357 CC denotes and
T10342 358-363 NN denotes Snail
T10343 363-364 . denotes .
T10344 364-542 sentence denotes Our functional studies demonstrate that without TGF-β2, Snail expression is abolished in the mutant hair buds, and conversely, in K14-Smad2 skin, Snail is ectopically activated.
T10345 365-368 PRP$ denotes Our
T10347 369-379 JJ denotes functional
T10346 380-387 NNS denotes studies
T10348 388-399 VBP denotes demonstrate
T10349 400-404 IN denotes that
T10351 405-412 IN denotes without
T10352 413-416 NN denotes TGF
T10354 416-417 HYPH denotes -
T10353 417-419 NN denotes β2
T10355 419-421 , denotes ,
T10356 421-426 NN denotes Snail
T10357 427-437 NN denotes expression
T10358 438-440 VBZ denotes is
T10350 441-450 VBN denotes abolished
T10359 451-453 IN denotes in
T10360 454-457 DT denotes the
T10362 458-464 NN denotes mutant
T10363 465-469 NN denotes hair
T10361 470-474 NNS denotes buds
T10364 474-476 , denotes ,
T10365 476-479 CC denotes and
T10366 480-490 RB denotes conversely
T10368 490-492 , denotes ,
T10369 492-494 IN denotes in
T10370 495-498 NN denotes K14
T10372 498-499 HYPH denotes -
T10371 499-504 NN denotes Smad2
T10373 505-509 NN denotes skin
T10374 509-511 , denotes ,
T10375 511-516 NN denotes Snail
T10376 517-519 VBZ denotes is
T10377 520-531 RB denotes ectopically
T10367 532-541 VBN denotes activated
T10378 541-542 . denotes .
T10379 542-773 sentence denotes Moreover, our in vitro studies indicate that even sustained TGF-β2 exposure may cause only a transient induction of Snail, offering a possible explanation as to why Snail is so briefly expressed during hair follicle morphogenesis.
T10380 543-551 RB denotes Moreover
T10382 551-553 , denotes ,
T10383 553-556 PRP$ denotes our
T10385 557-559 FW denotes in
T10386 560-565 FW denotes vitro
T10384 566-573 NNS denotes studies
T10381 574-582 VBP denotes indicate
T10387 583-587 IN denotes that
T10389 588-592 RB denotes even
T10391 593-602 JJ denotes sustained
T10392 603-606 NN denotes TGF
T10394 606-607 HYPH denotes -
T10393 607-609 NN denotes β2
T10390 610-618 NN denotes exposure
T10395 619-622 MD denotes may
T10388 623-628 VB denotes cause
T10396 629-633 RB denotes only
T10398 634-635 DT denotes a
T10399 636-645 JJ denotes transient
T10397 646-655 NN denotes induction
T10400 656-658 IN denotes of
T10401 659-664 NN denotes Snail
T10402 664-666 , denotes ,
T10403 666-674 VBG denotes offering
T10404 675-676 DT denotes a
T10406 677-685 JJ denotes possible
T10405 686-697 NN denotes explanation
T10407 698-700 IN denotes as
T10408 701-703 IN denotes to
T10409 704-707 WRB denotes why
T10411 708-713 NN denotes Snail
T10412 714-716 VBZ denotes is
T10413 717-719 RB denotes so
T10414 720-727 RB denotes briefly
T10410 728-737 VBN denotes expressed
T10415 738-744 IN denotes during
T10416 745-749 NN denotes hair
T10417 750-758 NN denotes follicle
T10418 759-772 NN denotes morphogenesis
T10419 772-773 . denotes .
T10420 773-1090 sentence denotes An additional point worth mentioning is that prolonged expression of Tg Snail in postnatal skin resulted in morphological and biochemical signs of epithelial to mesenchymal transitions (unpublished data), underscoring why transient Snail expression may be so important during normal hair follicle morphogenesis [18].
T10421 774-776 DT denotes An
T10423 777-787 JJ denotes additional
T10422 788-793 NN denotes point
T10425 794-799 JJ denotes worth
T10426 800-810 VBG denotes mentioning
T10424 811-813 VBZ denotes is
T10427 814-818 IN denotes that
T10429 819-828 VBN denotes prolonged
T10430 829-839 NN denotes expression
T10431 840-842 IN denotes of
T10432 843-845 NN denotes Tg
T10433 846-851 NN denotes Snail
T10434 852-854 IN denotes in
T10435 855-864 JJ denotes postnatal
T10436 865-869 NN denotes skin
T10428 870-878 VBD denotes resulted
T10437 879-881 IN denotes in
T10438 882-895 JJ denotes morphological
T10440 896-899 CC denotes and
T10441 900-911 JJ denotes biochemical
T10439 912-917 NNS denotes signs
T10442 918-920 IN denotes of
T10443 921-931 JJ denotes epithelial
T10445 932-934 IN denotes to
T10446 935-946 JJ denotes mesenchymal
T10444 947-958 NNS denotes transitions
T10447 959-960 -LRB- denotes (
T10449 960-971 JJ denotes unpublished
T10448 972-976 NNS denotes data
T10450 976-977 -RRB- denotes )
T10451 977-979 , denotes ,
T10452 979-991 VBG denotes underscoring
T10453 992-995 WRB denotes why
T10455 996-1005 JJ denotes transient
T10457 1006-1011 NN denotes Snail
T10456 1012-1022 NN denotes expression
T10458 1023-1026 MD denotes may
T10454 1027-1029 VB denotes be
T10459 1030-1032 RB denotes so
T10460 1033-1042 JJ denotes important
T10461 1043-1049 IN denotes during
T10462 1050-1056 JJ denotes normal
T10464 1057-1061 NN denotes hair
T10465 1062-1070 NN denotes follicle
T10463 1071-1084 NN denotes morphogenesis
T10466 1085-1086 -LRB- denotes [
T10467 1086-1088 CD denotes 18
T10468 1088-1089 -RRB- denotes ]
T10469 1089-1090 . denotes .
R6490 T10280 T10281 det The,identification
R6491 T10281 T10283 nsubj identification,was
R6492 T10282 T10281 amod prior,identification
R6493 T10284 T10281 prep of,identification
R6494 T10285 T10286 det the,gene
R6495 T10286 T10284 pobj gene,of
R6496 T10287 T10286 compound Snail,gene
R6497 T10288 T10281 prep as,identification
R6498 T10289 T10290 det a,target
R6499 T10290 T10288 pobj target,as
R6500 T10291 T10290 amod potential,target
R6501 T10292 T10290 prep of,target
R6502 T10293 T10294 compound TGF,β
R6503 T10294 T10296 compound β,signaling
R6504 T10295 T10294 punct -,β
R6505 T10296 T10292 pobj signaling,of
R6506 T10297 T10298 punct [,15
R6507 T10298 T10281 parataxis 15,identification
R6508 T10299 T10298 punct ],15
R6509 T10300 T10283 acomp intriguing,was
R6510 T10301 T10283 punct ", ",was
R6511 T10302 T10283 prep given,was
R6512 T10303 T10304 det the,wave
R6513 T10304 T10302 pobj wave,given
R6514 T10305 T10304 amod temporal,wave
R6515 T10306 T10304 prep of,wave
R6516 T10307 T10308 compound Snail,expression
R6517 T10308 T10306 pobj expression,of
R6518 T10309 T10308 compound gene,expression
R6519 T10310 T10311 dep that,occurs
R6520 T10311 T10304 relcl occurs,wave
R6521 T10312 T10311 prep in,occurs
R6522 T10313 T10314 det the,bud
R6523 T10314 T10312 pobj bud,in
R6524 T10315 T10314 amod developing,bud
R6525 T10316 T10314 compound hair,bud
R6526 T10317 T10283 punct .,was
R6527 T10319 T10320 det The,correlation
R6528 T10320 T10322 nsubj correlation,fostered
R6529 T10321 T10320 amod additional,correlation
R6530 T10323 T10320 prep between,correlation
R6531 T10324 T10325 amod epithelial,hyperproliferation
R6532 T10325 T10323 pobj hyperproliferation,between
R6533 T10326 T10325 cc and,hyperproliferation
R6534 T10327 T10328 compound Snail,expression
R6535 T10328 T10325 conj expression,hyperproliferation
R6536 T10329 T10328 compound transgene,expression
R6537 T10330 T10322 advmod further,fostered
R6538 T10331 T10332 poss our,interest
R6539 T10332 T10322 dobj interest,fostered
R6540 T10333 T10332 prep in,interest
R6541 T10334 T10335 det a,link
R6542 T10335 T10333 pobj link,in
R6543 T10336 T10335 amod possible,link
R6544 T10337 T10335 prep between,link
R6545 T10338 T10339 compound TGF,β2
R6546 T10339 T10337 pobj β2,between
R6547 T10340 T10339 punct -,β2
R6548 T10341 T10339 cc and,β2
R6549 T10342 T10339 conj Snail,β2
R6550 T10343 T10322 punct .,fostered
R6551 T10345 T10346 poss Our,studies
R6552 T10346 T10348 nsubj studies,demonstrate
R6553 T10347 T10346 amod functional,studies
R6554 T10349 T10350 mark that,abolished
R6555 T10350 T10348 ccomp abolished,demonstrate
R6556 T10351 T10350 prep without,abolished
R6557 T10352 T10353 compound TGF,β2
R6558 T10353 T10351 pobj β2,without
R6559 T10354 T10353 punct -,β2
R6560 T10355 T10350 punct ", ",abolished
R6561 T10356 T10357 compound Snail,expression
R6562 T10357 T10350 nsubjpass expression,abolished
R6563 T10358 T10350 auxpass is,abolished
R6564 T10359 T10350 prep in,abolished
R6565 T10360 T10361 det the,buds
R6566 T10361 T10359 pobj buds,in
R6567 T10362 T10361 compound mutant,buds
R6568 T10363 T10361 compound hair,buds
R6569 T10364 T10350 punct ", ",abolished
R6570 T10365 T10350 cc and,abolished
R6571 T10366 T10367 advmod conversely,activated
R6572 T10367 T10350 conj activated,abolished
R6573 T10368 T10367 punct ", ",activated
R6574 T10369 T10367 prep in,activated
R6575 T10370 T10371 compound K14,Smad2
R6576 T10371 T10373 compound Smad2,skin
R6577 T10372 T10371 punct -,Smad2
R6578 T10373 T10369 pobj skin,in
R6579 T10374 T10367 punct ", ",activated
R6580 T10375 T10367 nsubjpass Snail,activated
R6581 T10376 T10367 auxpass is,activated
R6582 T10377 T10367 advmod ectopically,activated
R6583 T10378 T10348 punct .,demonstrate
R6584 T10380 T10381 advmod Moreover,indicate
R6585 T10382 T10381 punct ", ",indicate
R6586 T10383 T10384 poss our,studies
R6587 T10384 T10381 nsubj studies,indicate
R6588 T10385 T10386 advmod in,vitro
R6589 T10386 T10384 amod vitro,studies
R6590 T10387 T10388 mark that,cause
R6591 T10388 T10381 ccomp cause,indicate
R6592 T10389 T10390 advmod even,exposure
R6593 T10390 T10388 nsubj exposure,cause
R6594 T10391 T10390 amod sustained,exposure
R6595 T10392 T10393 compound TGF,β2
R6596 T10393 T10390 compound β2,exposure
R6597 T10394 T10393 punct -,β2
R6598 T10395 T10388 aux may,cause
R6599 T10396 T10397 advmod only,induction
R6600 T10397 T10388 dobj induction,cause
R6601 T10398 T10397 det a,induction
R6602 T10399 T10397 amod transient,induction
R6603 T10400 T10397 prep of,induction
R6604 T10401 T10400 pobj Snail,of
R6605 T10402 T10381 punct ", ",indicate
R6606 T10403 T10381 advcl offering,indicate
R6607 T10404 T10405 det a,explanation
R6608 T10405 T10403 dobj explanation,offering
R6609 T10406 T10405 amod possible,explanation
R6610 T10407 T10405 prep as,explanation
R6611 T10408 T10407 prep to,as
R6612 T10409 T10410 advmod why,expressed
R6613 T10410 T10408 pcomp expressed,to
R6614 T10411 T10410 nsubjpass Snail,expressed
R6615 T10412 T10410 auxpass is,expressed
R6616 T10413 T10414 advmod so,briefly
R6617 T10414 T10410 advmod briefly,expressed
R6618 T10415 T10410 prep during,expressed
R6619 T10416 T10417 compound hair,follicle
R6620 T10417 T10418 compound follicle,morphogenesis
R6621 T10418 T10415 pobj morphogenesis,during
R6622 T10419 T10381 punct .,indicate
R6623 T10421 T10422 det An,point
R6624 T10422 T10424 nsubj point,is
R6625 T10423 T10422 amod additional,point
R6626 T10425 T10422 amod worth,point
R6627 T10426 T10425 advcl mentioning,worth
R6628 T10427 T10428 mark that,resulted
R6629 T10428 T10424 ccomp resulted,is
R6630 T10429 T10430 amod prolonged,expression
R6631 T10430 T10428 nsubj expression,resulted
R6632 T10431 T10430 prep of,expression
R6633 T10432 T10433 compound Tg,Snail
R6634 T10433 T10431 pobj Snail,of
R6635 T10434 T10430 prep in,expression
R6636 T10435 T10436 amod postnatal,skin
R6637 T10436 T10434 pobj skin,in
R6638 T10437 T10428 prep in,resulted
R6639 T10438 T10439 amod morphological,signs
R6640 T10439 T10437 pobj signs,in
R6641 T10440 T10438 cc and,morphological
R6642 T10441 T10438 conj biochemical,morphological
R6643 T10442 T10439 prep of,signs
R6644 T10443 T10444 amod epithelial,transitions
R6645 T10444 T10442 pobj transitions,of
R6646 T10445 T10443 prep to,epithelial
R6647 T10446 T10445 amod mesenchymal,to
R6648 T10447 T10448 punct (,data
R6649 T10448 T10428 meta data,resulted
R6650 T10449 T10448 amod unpublished,data
R6651 T10450 T10448 punct ),data
R6652 T10451 T10428 punct ", ",resulted
R6653 T10452 T10428 advcl underscoring,resulted
R6654 T10453 T10454 advmod why,be
R6655 T10454 T10452 ccomp be,underscoring
R6656 T10455 T10456 amod transient,expression
R6657 T10456 T10454 nsubj expression,be
R6658 T10457 T10456 compound Snail,expression
R6659 T10458 T10454 aux may,be
R6660 T10459 T10460 advmod so,important
R6661 T10460 T10454 acomp important,be
R6662 T10461 T10454 prep during,be
R6663 T10462 T10463 amod normal,morphogenesis
R6664 T10463 T10461 pobj morphogenesis,during
R6665 T10464 T10465 compound hair,follicle
R6666 T10465 T10463 compound follicle,morphogenesis
R6667 T10466 T10467 punct [,18
R6668 T10467 T10424 parataxis 18,is
R6669 T10468 T10467 punct ],18
R6670 T10469 T10424 punct .,is