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PMC:539061 / 4463-6112 JSONTXT 5 Projects

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Id Subject Object Predicate Lexical cue
T1505 0-10 RB denotes Previously
T1507 10-12 , denotes ,
T1508 12-14 PRP denotes we
T1506 15-25 VBD denotes delineated
T1509 26-29 WRB denotes how
T1511 30-33 CD denotes two
T1513 34-44 JJ denotes respective
T1514 45-55 JJ denotes epithelial
T1515 56-59 CC denotes and
T1516 60-71 JJ denotes mesenchymal
T1512 72-79 NNS denotes signals
T1517 79-81 , denotes ,
T1518 81-85 NNS denotes Wnts
T1519 86-89 CC denotes and
T1520 90-93 DT denotes the
T1522 94-97 NN denotes BMP
T1524 97-98 HYPH denotes -
T1523 98-108 JJ denotes inhibitory
T1521 109-115 NN denotes factor
T1525 116-122 NN denotes noggin
T1526 122-124 , denotes ,
T1510 124-132 VBP denotes function
T1527 133-135 IN denotes in
T1528 136-143 NN denotes concert
T1529 144-146 TO denotes to
T1530 147-153 VB denotes induce
T1531 154-162 JJ denotes lymphoid
T1533 163-171 NN denotes enhancer
T1532 172-178 NN denotes factor
T1535 178-179 HYPH denotes -
T1536 179-180 CD denotes 1
T1537 180-181 HYPH denotes /
T1538 181-182 NN denotes β
T1540 182-183 HYPH denotes -
T1539 183-190 NN denotes catenin
T1541 191-192 -LRB- denotes (
T1542 192-195 NN denotes LEF
T1543 195-196 HYPH denotes -
T1544 196-197 CD denotes 1
T1545 197-198 HYPH denotes /
T1546 198-199 NN denotes β
T1548 199-200 HYPH denotes -
T1547 200-207 NN denotes catenin
T1549 207-208 -RRB- denotes )
T1550 208-209 HYPH denotes -
T1534 209-217 VBN denotes mediated
T1552 218-222 NN denotes gene
T1551 223-236 NN denotes transcription
T1553 237-243 IN denotes within
T1554 244-247 DT denotes the
T1556 248-256 NN denotes follicle
T1555 257-264 NN denotes placode
T1557 265-266 -LRB- denotes [
T1558 266-267 CD denotes 4
T1559 267-268 -RRB- denotes ]
T1560 268-269 . denotes .
T1561 269-534 sentence denotes The downstream changes elicited through convergence of these two early signaling pathways include down-regulation of the gene encoding E-cadherin, the prototypical epithelial cadherin that forms the transmembrane core of intercellular adherens junctions (AJs) [5].
T1562 270-273 DT denotes The
T1564 274-284 JJ denotes downstream
T1563 285-292 NNS denotes changes
T1566 293-301 VBN denotes elicited
T1567 302-309 IN denotes through
T1568 310-321 NN denotes convergence
T1569 322-324 IN denotes of
T1570 325-330 DT denotes these
T1572 331-334 CD denotes two
T1573 335-340 JJ denotes early
T1574 341-350 NN denotes signaling
T1571 351-359 NNS denotes pathways
T1565 360-367 VBP denotes include
T1575 368-372 JJ denotes down
T1577 372-373 HYPH denotes -
T1576 373-383 NN denotes regulation
T1578 384-386 IN denotes of
T1579 387-390 DT denotes the
T1580 391-395 NN denotes gene
T1581 396-404 VBG denotes encoding
T1582 405-406 NN denotes E
T1584 406-407 HYPH denotes -
T1583 407-415 NN denotes cadherin
T1585 415-417 , denotes ,
T1586 417-420 DT denotes the
T1588 421-433 JJ denotes prototypical
T1589 434-444 JJ denotes epithelial
T1587 445-453 NN denotes cadherin
T1590 454-458 WDT denotes that
T1591 459-464 VBZ denotes forms
T1592 465-468 DT denotes the
T1594 469-482 JJ denotes transmembrane
T1593 483-487 NN denotes core
T1595 488-490 IN denotes of
T1596 491-504 JJ denotes intercellular
T1598 505-513 NN denotes adherens
T1597 514-523 NNS denotes junctions
T1599 524-525 -LRB- denotes (
T1600 525-528 NNS denotes AJs
T1601 528-529 -RRB- denotes )
T1602 530-531 -LRB- denotes [
T1603 531-532 CD denotes 5
T1604 532-533 -RRB- denotes ]
T1605 533-534 . denotes .
T1606 534-799 sentence denotes We subsequently showed that when E-cadherin is transgenically elevated in mouse skin, hair follicle morphogenesis is blocked, suggesting that E-cadherin down-regulation is a critical event in governing the adhesion dynamics necessary for budding morphogenesis [4].
T1607 535-537 PRP denotes We
T1609 538-550 RB denotes subsequently
T1608 551-557 VBD denotes showed
T1610 558-562 IN denotes that
T1612 563-567 WRB denotes when
T1614 568-569 NN denotes E
T1616 569-570 HYPH denotes -
T1615 570-578 NN denotes cadherin
T1617 579-581 VBZ denotes is
T1618 582-596 RB denotes transgenically
T1613 597-605 VBN denotes elevated
T1619 606-608 IN denotes in
T1620 609-614 NN denotes mouse
T1621 615-619 NN denotes skin
T1622 619-621 , denotes ,
T1623 621-625 NN denotes hair
T1624 626-634 NN denotes follicle
T1625 635-648 NN denotes morphogenesis
T1626 649-651 VBZ denotes is
T1611 652-659 VBN denotes blocked
T1627 659-661 , denotes ,
T1628 661-671 VBG denotes suggesting
T1629 672-676 IN denotes that
T1631 677-678 NN denotes E
T1633 678-679 HYPH denotes -
T1632 679-687 NN denotes cadherin
T1635 688-692 JJ denotes down
T1636 692-693 HYPH denotes -
T1634 693-703 NN denotes regulation
T1630 704-706 VBZ denotes is
T1637 707-708 DT denotes a
T1639 709-717 JJ denotes critical
T1638 718-723 NN denotes event
T1640 724-726 IN denotes in
T1641 727-736 VBG denotes governing
T1642 737-740 DT denotes the
T1644 741-749 NN denotes adhesion
T1643 750-758 NNS denotes dynamics
T1645 759-768 JJ denotes necessary
T1646 769-772 IN denotes for
T1647 773-780 NN denotes budding
T1648 781-794 NN denotes morphogenesis
T1649 795-796 -LRB- denotes [
T1650 796-797 CD denotes 4
T1651 797-798 -RRB- denotes ]
T1652 798-799 . denotes .
T1653 799-847 sentence denotes Like LEF-1, E-cadherin also binds to β-catenin.
T1654 800-804 IN denotes Like
T1656 805-808 NN denotes LEF
T1657 808-809 HYPH denotes -
T1658 809-810 CD denotes 1
T1659 810-812 , denotes ,
T1660 812-813 NN denotes E
T1662 813-814 HYPH denotes -
T1661 814-822 NN denotes cadherin
T1663 823-827 RB denotes also
T1655 828-833 VBZ denotes binds
T1664 834-836 IN denotes to
T1665 837-838 NN denotes β
T1667 838-839 HYPH denotes -
T1666 839-846 NN denotes catenin
T1668 846-847 . denotes .
T1669 847-1110 sentence denotes At sites of cell-cell contact, however, E-cadherin-β-catenin complexes recruit α-catenin, which in turn coordinates the associated actin polymerization dynamics necessary to stabilize nascent AJs and integrate the cytoskeleton across an epithelial sheet [6,7,8].
T1670 848-850 IN denotes At
T1672 851-856 NNS denotes sites
T1673 857-859 IN denotes of
T1674 860-864 NN denotes cell
T1676 864-865 HYPH denotes -
T1675 865-869 NN denotes cell
T1677 870-877 NN denotes contact
T1678 877-879 , denotes ,
T1679 879-886 RB denotes however
T1680 886-888 , denotes ,
T1681 888-889 NN denotes E
T1683 889-890 HYPH denotes -
T1682 890-898 NN denotes cadherin
T1685 898-899 HYPH denotes -
T1686 899-900 NN denotes β
T1688 900-901 HYPH denotes -
T1687 901-908 NN denotes catenin
T1684 909-918 NNS denotes complexes
T1671 919-926 VBP denotes recruit
T1689 927-928 NN denotes α
T1691 928-929 HYPH denotes -
T1690 929-936 NN denotes catenin
T1692 936-938 , denotes ,
T1693 938-943 WDT denotes which
T1695 944-946 IN denotes in
T1696 947-951 NN denotes turn
T1694 952-963 VBZ denotes coordinates
T1697 964-967 DT denotes the
T1699 968-978 VBN denotes associated
T1700 979-984 NN denotes actin
T1701 985-999 NN denotes polymerization
T1698 1000-1008 NNS denotes dynamics
T1702 1009-1018 JJ denotes necessary
T1703 1019-1021 TO denotes to
T1704 1022-1031 VB denotes stabilize
T1705 1032-1039 JJ denotes nascent
T1706 1040-1043 NNS denotes AJs
T1707 1044-1047 CC denotes and
T1708 1048-1057 VB denotes integrate
T1709 1058-1061 DT denotes the
T1710 1062-1074 NN denotes cytoskeleton
T1711 1075-1081 IN denotes across
T1712 1082-1084 DT denotes an
T1714 1085-1095 JJ denotes epithelial
T1713 1096-1101 NN denotes sheet
T1715 1102-1103 -LRB- denotes [
T1717 1103-1104 CD denotes 6
T1718 1104-1105 , denotes ,
T1719 1105-1106 CD denotes 7
T1720 1106-1107 , denotes ,
T1716 1107-1108 CD denotes 8
T1721 1108-1109 -RRB- denotes ]
T1722 1109-1110 . denotes .
T1723 1110-1367 sentence denotes α-Catenin also binds to the class III Lin-1, Isl-1, Mec-3 (LIM) protein Ajuba (a member of the zyxin family of proteins), which appears to function dually in both adhesion and in activation of the Ras-mitogen-activated protein kinase (MAPK) pathway [9,10].
T1724 1111-1112 NN denotes α
T1726 1112-1113 HYPH denotes -
T1725 1113-1120 NN denotes Catenin
T1728 1121-1125 RB denotes also
T1727 1126-1131 VBZ denotes binds
T1729 1132-1134 IN denotes to
T1730 1135-1138 DT denotes the
T1732 1139-1144 NN denotes class
T1733 1145-1148 CD denotes III
T1734 1149-1152 NN denotes Lin
T1735 1152-1153 HYPH denotes -
T1736 1153-1154 CD denotes 1
T1737 1154-1156 , denotes ,
T1738 1156-1159 NN denotes Isl
T1739 1159-1160 HYPH denotes -
T1740 1160-1161 CD denotes 1
T1741 1161-1163 , denotes ,
T1742 1163-1166 NN denotes Mec
T1743 1166-1167 HYPH denotes -
T1744 1167-1168 CD denotes 3
T1745 1169-1170 -LRB- denotes (
T1746 1170-1173 NN denotes LIM
T1747 1173-1174 -RRB- denotes )
T1731 1175-1182 NN denotes protein
T1748 1183-1188 NN denotes Ajuba
T1749 1189-1190 -LRB- denotes (
T1750 1190-1191 DT denotes a
T1751 1192-1198 NN denotes member
T1752 1199-1201 IN denotes of
T1753 1202-1205 DT denotes the
T1755 1206-1211 NN denotes zyxin
T1754 1212-1218 NN denotes family
T1756 1219-1221 IN denotes of
T1757 1222-1230 NN denotes proteins
T1758 1230-1231 -RRB- denotes )
T1759 1231-1233 , denotes ,
T1760 1233-1238 WDT denotes which
T1761 1239-1246 VBZ denotes appears
T1762 1247-1249 TO denotes to
T1763 1250-1258 VB denotes function
T1764 1259-1265 RB denotes dually
T1765 1266-1268 IN denotes in
T1766 1269-1273 CC denotes both
T1767 1274-1282 NN denotes adhesion
T1768 1283-1286 CC denotes and
T1769 1287-1289 IN denotes in
T1770 1290-1300 NN denotes activation
T1771 1301-1303 IN denotes of
T1772 1304-1307 DT denotes the
T1774 1308-1311 NN denotes Ras
T1775 1311-1312 HYPH denotes -
T1776 1312-1319 NN denotes mitogen
T1778 1319-1320 HYPH denotes -
T1777 1320-1329 VBN denotes activated
T1780 1330-1337 NN denotes protein
T1779 1338-1344 NN denotes kinase
T1781 1345-1346 -LRB- denotes (
T1782 1346-1350 NN denotes MAPK
T1783 1350-1351 -RRB- denotes )
T1773 1352-1359 NN denotes pathway
T1784 1360-1361 -LRB- denotes [
T1786 1361-1362 CD denotes 9
T1787 1362-1363 , denotes ,
T1785 1363-1365 CD denotes 10
T1788 1365-1366 -RRB- denotes ]
T1789 1366-1367 . denotes .
T1790 1367-1501 sentence denotes Through these links, AJs appear able to couple adhesion with cytoskeletal dynamics as well as with nuclear and cytoplasmic signaling.
T1791 1368-1375 IN denotes Through
T1793 1376-1381 DT denotes these
T1794 1382-1387 NNS denotes links
T1795 1387-1389 , denotes ,
T1796 1389-1392 NNS denotes AJs
T1792 1393-1399 VBP denotes appear
T1797 1400-1404 JJ denotes able
T1798 1405-1407 TO denotes to
T1799 1408-1414 VB denotes couple
T1800 1415-1423 NN denotes adhesion
T1801 1424-1428 IN denotes with
T1802 1429-1441 JJ denotes cytoskeletal
T1803 1442-1450 NNS denotes dynamics
T1804 1451-1453 RB denotes as
T1806 1454-1458 RB denotes well
T1805 1459-1461 IN denotes as
T1807 1462-1466 IN denotes with
T1808 1467-1474 JJ denotes nuclear
T1810 1475-1478 CC denotes and
T1811 1479-1490 JJ denotes cytoplasmic
T1809 1491-1500 NN denotes signaling
T1812 1500-1501 . denotes .
T1813 1501-1649 sentence denotes This provides a framework for conceptualizing why E-cadherin levels appear to impact upon a plethora of developmental processes (reviewed in [11]).
T1814 1502-1506 DT denotes This
T1815 1507-1515 VBZ denotes provides
T1816 1516-1517 DT denotes a
T1817 1518-1527 NN denotes framework
T1818 1528-1531 IN denotes for
T1819 1532-1547 VBG denotes conceptualizing
T1820 1548-1551 WRB denotes why
T1822 1552-1553 NN denotes E
T1824 1553-1554 HYPH denotes -
T1823 1554-1562 NN denotes cadherin
T1825 1563-1569 NNS denotes levels
T1821 1570-1576 VBP denotes appear
T1826 1577-1579 TO denotes to
T1827 1580-1586 VB denotes impact
T1828 1587-1591 IN denotes upon
T1829 1592-1593 DT denotes a
T1830 1594-1602 NN denotes plethora
T1831 1603-1605 IN denotes of
T1832 1606-1619 JJ denotes developmental
T1833 1620-1629 NNS denotes processes
T1834 1630-1631 -LRB- denotes (
T1835 1631-1639 VBN denotes reviewed
T1836 1640-1642 IN denotes in
T1837 1643-1644 -LRB- denotes [
T1838 1644-1646 CD denotes 11
T1839 1646-1647 -RRB- denotes ]
T1840 1647-1648 -RRB- denotes )
T1841 1648-1649 . denotes .
R1002 T1757 T1756 pobj proteins,of
R1005 T1758 T1731 punct ),protein
R1006 T1759 T1731 punct ", ",protein
R1010 T1760 T1761 dep which,appears
R1013 T1761 T1731 relcl appears,protein
R1015 T1762 T1763 aux to,function
R1019 T1763 T1761 xcomp function,appears
R1023 T1764 T1763 advmod dually,function
R1026 T1765 T1763 prep in,function
R1030 T1766 T1765 preconj both,in
R1031 T1767 T1765 conj adhesion,in
R1032 T1768 T1765 cc and,in
R1033 T1769 T1765 conj in,in
R1036 T1770 T1769 pobj activation,in
R1040 T1771 T1770 prep of,activation
R1043 T1772 T1773 det the,pathway
R1047 T1773 T1771 pobj pathway,of
R1054 T1774 T1773 nmod Ras,pathway
R1058 T1775 T1774 punct -,Ras
R1060 T1776 T1777 npadvmod mitogen,activated
R1063 T1777 T1779 amod activated,kinase
R1067 T1778 T1777 punct -,activated
R1071 T1779 T1774 appos kinase,Ras
R681 T1505 T1506 advmod Previously,delineated
R682 T1507 T1506 punct ", ",delineated
R683 T1508 T1506 nsubj we,delineated
R684 T1509 T1510 advmod how,function
R685 T1510 T1506 ccomp function,delineated
R686 T1511 T1512 nummod two,signals
R687 T1512 T1510 nsubj signals,function
R688 T1513 T1512 amod respective,signals
R689 T1514 T1512 amod epithelial,signals
R690 T1515 T1514 cc and,epithelial
R691 T1516 T1514 conj mesenchymal,epithelial
R692 T1517 T1512 punct ", ",signals
R693 T1518 T1512 appos Wnts,signals
R694 T1519 T1518 cc and,Wnts
R695 T1520 T1521 det the,factor
R696 T1521 T1518 conj factor,Wnts
R697 T1522 T1523 npadvmod BMP,inhibitory
R698 T1523 T1521 amod inhibitory,factor
R699 T1524 T1523 punct -,inhibitory
R700 T1525 T1521 appos noggin,factor
R701 T1526 T1510 punct ", ",function
R702 T1527 T1510 prep in,function
R703 T1528 T1527 pobj concert,in
R704 T1529 T1530 aux to,induce
R705 T1530 T1510 advcl induce,function
R706 T1531 T1532 amod lymphoid,factor
R707 T1532 T1534 npadvmod factor,mediated
R708 T1533 T1532 compound enhancer,factor
R709 T1534 T1551 amod mediated,transcription
R710 T1535 T1532 punct -,factor
R711 T1536 T1532 nummod 1,factor
R712 T1537 T1532 punct /,factor
R713 T1538 T1539 compound β,catenin
R714 T1539 T1532 appos catenin,factor
R715 T1540 T1539 punct -,catenin
R716 T1541 T1532 punct (,factor
R717 T1542 T1532 appos LEF,factor
R718 T1543 T1542 punct -,LEF
R719 T1544 T1542 nummod 1,LEF
R720 T1545 T1542 punct /,LEF
R721 T1546 T1547 compound β,catenin
R722 T1547 T1542 appos catenin,LEF
R723 T1548 T1547 punct -,catenin
R724 T1549 T1534 punct ),mediated
R725 T1550 T1534 punct -,mediated
R726 T1551 T1530 dobj transcription,induce
R727 T1552 T1551 compound gene,transcription
R728 T1553 T1530 prep within,induce
R729 T1554 T1555 det the,placode
R730 T1555 T1553 pobj placode,within
R731 T1556 T1555 compound follicle,placode
R732 T1557 T1558 punct [,4
R733 T1558 T1506 parataxis 4,delineated
R734 T1559 T1558 punct ],4
R735 T1560 T1506 punct .,delineated
R736 T1562 T1563 det The,changes
R737 T1563 T1565 nsubj changes,include
R738 T1564 T1563 amod downstream,changes
R739 T1566 T1563 acl elicited,changes
R740 T1567 T1566 prep through,elicited
R741 T1568 T1567 pobj convergence,through
R742 T1569 T1568 prep of,convergence
R743 T1675 T1677 compound cell,contact
R744 T1676 T1675 punct -,cell
R745 T1677 T1673 pobj contact,of
R746 T1678 T1671 punct ", ",recruit
R747 T1679 T1671 advmod however,recruit
R748 T1570 T1571 det these,pathways
R749 T1680 T1671 punct ", ",recruit
R750 T1571 T1569 pobj pathways,of
R751 T1681 T1682 nmod E,cadherin
R752 T1572 T1571 nummod two,pathways
R753 T1573 T1571 amod early,pathways
R754 T1682 T1684 nmod cadherin,complexes
R755 T1574 T1571 compound signaling,pathways
R756 T1575 T1576 amod down,regulation
R757 T1683 T1682 punct -,cadherin
R758 T1576 T1565 dobj regulation,include
R759 T1577 T1576 punct -,regulation
R760 T1578 T1576 prep of,regulation
R761 T1684 T1671 nsubj complexes,recruit
R762 T1579 T1580 det the,gene
R763 T1580 T1578 pobj gene,of
R764 T1685 T1682 punct -,cadherin
R765 T1581 T1580 acl encoding,gene
R766 T1582 T1583 compound E,cadherin
R767 T1583 T1581 dobj cadherin,encoding
R768 T1686 T1687 compound β,catenin
R769 T1584 T1583 punct -,cadherin
R770 T1585 T1583 punct ", ",cadherin
R771 T1586 T1587 det the,cadherin
R772 T1687 T1682 appos catenin,cadherin
R773 T1587 T1583 appos cadherin,cadherin
R774 T1588 T1587 amod prototypical,cadherin
R775 T1688 T1687 punct -,catenin
R776 T1589 T1587 amod epithelial,cadherin
R777 T1590 T1591 dep that,forms
R778 T1591 T1587 relcl forms,cadherin
R779 T1689 T1690 compound α,catenin
R780 T1592 T1593 det the,core
R781 T1593 T1591 dobj core,forms
R782 T1690 T1671 dobj catenin,recruit
R783 T1594 T1593 amod transmembrane,core
R784 T1595 T1593 prep of,core
R785 T1596 T1597 amod intercellular,junctions
R786 T1691 T1690 punct -,catenin
R787 T1597 T1595 pobj junctions,of
R788 T1598 T1597 compound adherens,junctions
R789 T1599 T1597 punct (,junctions
R790 T1692 T1690 punct ", ",catenin
R791 T1600 T1597 appos AJs,junctions
R792 T1601 T1565 punct ),include
R793 T1602 T1603 punct [,5
R794 T1603 T1565 parataxis 5,include
R795 T1604 T1603 punct ],5
R796 T1693 T1694 dep which,coordinates
R797 T1605 T1565 punct .,include
R798 T1607 T1608 nsubj We,showed
R799 T1694 T1690 relcl coordinates,catenin
R800 T1609 T1608 advmod subsequently,showed
R801 T1695 T1694 prep in,coordinates
R802 T1610 T1611 mark that,blocked
R803 T1696 T1695 pobj turn,in
R804 T1611 T1608 ccomp blocked,showed
R805 T1697 T1698 det the,dynamics
R806 T1612 T1613 advmod when,elevated
R807 T1613 T1611 advcl elevated,blocked
R808 T1698 T1694 dobj dynamics,coordinates
R809 T1614 T1615 compound E,cadherin
R810 T1615 T1613 nsubjpass cadherin,elevated
R811 T1616 T1615 punct -,cadherin
R812 T1699 T1698 amod associated,dynamics
R813 T1617 T1613 auxpass is,elevated
R814 T1618 T1613 advmod transgenically,elevated
R815 T1700 T1698 compound actin,dynamics
R816 T1619 T1613 prep in,elevated
R817 T1620 T1621 compound mouse,skin
R818 T1621 T1619 pobj skin,in
R819 T1701 T1698 compound polymerization,dynamics
R820 T1622 T1611 punct ", ",blocked
R821 T1623 T1624 compound hair,follicle
R822 T1624 T1625 compound follicle,morphogenesis
R823 T1702 T1698 amod necessary,dynamics
R824 T1625 T1611 nsubjpass morphogenesis,blocked
R825 T1626 T1611 auxpass is,blocked
R826 T1627 T1611 punct ", ",blocked
R827 T1703 T1704 aux to,stabilize
R828 T1628 T1611 advcl suggesting,blocked
R829 T1629 T1630 mark that,is
R830 T1630 T1628 ccomp is,suggesting
R831 T1704 T1702 xcomp stabilize,necessary
R832 T1631 T1632 nmod E,cadherin
R833 T1632 T1634 nmod cadherin,regulation
R834 T1705 T1706 amod nascent,AJs
R835 T1633 T1632 punct -,cadherin
R836 T1634 T1630 nsubj regulation,is
R837 T1635 T1634 amod down,regulation
R838 T1706 T1704 dobj AJs,stabilize
R839 T1636 T1634 punct -,regulation
R840 T1637 T1638 det a,event
R841 T1638 T1630 attr event,is
R842 T1639 T1638 amod critical,event
R843 T1640 T1638 prep in,event
R844 T1707 T1704 cc and,stabilize
R845 T1708 T1704 conj integrate,stabilize
R846 T1641 T1640 pcomp governing,in
R847 T1709 T1710 det the,cytoskeleton
R848 T1642 T1643 det the,dynamics
R849 T1643 T1641 dobj dynamics,governing
R850 T1644 T1643 compound adhesion,dynamics
R851 T1710 T1708 dobj cytoskeleton,integrate
R852 T1645 T1643 amod necessary,dynamics
R853 T1646 T1645 prep for,necessary
R854 T1647 T1648 compound budding,morphogenesis
R855 T1711 T1708 prep across,integrate
R856 T1648 T1646 pobj morphogenesis,for
R857 T1649 T1650 punct [,4
R858 T1712 T1713 det an,sheet
R859 T1650 T1608 parataxis 4,showed
R860 T1651 T1650 punct ],4
R861 T1652 T1608 punct .,showed
R862 T1713 T1711 pobj sheet,across
R863 T1654 T1655 prep Like,binds
R864 T1714 T1713 amod epithelial,sheet
R865 T1656 T1654 pobj LEF,Like
R866 T1657 T1656 punct -,LEF
R867 T1715 T1716 punct [,8
R868 T1658 T1656 nummod 1,LEF
R869 T1659 T1655 punct ", ",binds
R870 T1660 T1661 compound E,cadherin
R871 T1661 T1655 nsubj cadherin,binds
R872 T1716 T1694 parataxis 8,coordinates
R873 T1662 T1661 punct -,cadherin
R874 T1663 T1655 advmod also,binds
R875 T1717 T1716 nummod 6,8
R876 T1664 T1655 prep to,binds
R877 T1665 T1666 compound β,catenin
R878 T1666 T1664 pobj catenin,to
R879 T1718 T1716 punct ",",8
R880 T1667 T1666 punct -,catenin
R881 T1668 T1655 punct .,binds
R882 T1719 T1716 nummod 7,8
R883 T1670 T1671 prep At,recruit
R884 T1720 T1716 punct ",",8
R885 T1672 T1670 pobj sites,At
R886 T1673 T1672 prep of,sites
R887 T1674 T1675 compound cell,cell
R888 T1721 T1716 punct ],8
R889 T1722 T1671 punct .,recruit
R890 T1724 T1725 compound α,Catenin
R891 T1725 T1727 nsubj Catenin,binds
R892 T1726 T1725 punct -,Catenin
R893 T1780 T1779 compound protein,kinase
R894 T1781 T1779 punct (,kinase
R895 T1782 T1779 appos MAPK,kinase
R896 T1728 T1727 advmod also,binds
R897 T1783 T1773 punct ),pathway
R898 T1784 T1785 punct [,10
R899 T1729 T1727 prep to,binds
R900 T1785 T1727 parataxis 10,binds
R901 T1786 T1785 nummod 9,10
R902 T1730 T1731 det the,protein
R903 T1787 T1785 punct ",",10
R904 T1788 T1785 punct ],10
R905 T1731 T1729 pobj protein,to
R906 T1789 T1727 punct .,binds
R907 T1732 T1731 nmod class,protein
R908 T1791 T1792 prep Through,appear
R909 T1793 T1794 det these,links
R910 T1733 T1732 nummod III,class
R911 T1794 T1791 pobj links,Through
R912 T1795 T1792 punct ", ",appear
R913 T1734 T1731 nmod Lin,protein
R914 T1796 T1792 nsubj AJs,appear
R915 T1797 T1792 oprd able,appear
R916 T1798 T1799 aux to,couple
R917 T1735 T1734 punct -,Lin
R918 T1799 T1797 xcomp couple,able
R919 T1800 T1799 dobj adhesion,couple
R920 T1736 T1734 nummod 1,Lin
R921 T1801 T1799 prep with,couple
R922 T1802 T1803 amod cytoskeletal,dynamics
R923 T1803 T1801 pobj dynamics,with
R924 T1737 T1734 punct ", ",Lin
R925 T1804 T1805 advmod as,as
R926 T1805 T1801 cc as,with
R927 T1806 T1805 advmod well,as
R928 T1738 T1734 appos Isl,Lin
R929 T1807 T1801 conj with,with
R930 T1808 T1809 amod nuclear,signaling
R931 T1739 T1738 punct -,Isl
R932 T1809 T1807 pobj signaling,with
R933 T1810 T1808 cc and,nuclear
R934 T1811 T1808 conj cytoplasmic,nuclear
R935 T1740 T1738 nummod 1,Isl
R936 T1812 T1792 punct .,appear
R937 T1814 T1815 nsubj This,provides
R938 T1741 T1734 punct ", ",Lin
R939 T1816 T1817 det a,framework
R940 T1742 T1734 appos Mec,Lin
R941 T1817 T1815 dobj framework,provides
R942 T1818 T1817 prep for,framework
R943 T1819 T1818 pcomp conceptualizing,for
R944 T1820 T1821 advmod why,appear
R945 T1821 T1819 ccomp appear,conceptualizing
R946 T1822 T1823 compound E,cadherin
R947 T1743 T1742 punct -,Mec
R948 T1823 T1825 compound cadherin,levels
R949 T1824 T1823 punct -,cadherin
R950 T1825 T1821 nsubj levels,appear
R951 T1826 T1827 aux to,impact
R952 T1744 T1742 nummod 3,Mec
R953 T1827 T1821 xcomp impact,appear
R954 T1828 T1827 prep upon,impact
R955 T1745 T1734 punct (,Lin
R956 T1829 T1830 det a,plethora
R957 T1830 T1828 pobj plethora,upon
R958 T1831 T1830 prep of,plethora
R959 T1746 T1734 appos LIM,Lin
R960 T1832 T1833 amod developmental,processes
R961 T1833 T1831 pobj processes,of
R962 T1834 T1835 punct (,reviewed
R963 T1747 T1731 punct ),protein
R964 T1835 T1815 parataxis reviewed,provides
R965 T1836 T1835 prep in,reviewed
R966 T1837 T1836 punct [,in
R967 T1748 T1731 appos Ajuba,protein
R968 T1838 T1836 pobj 11,in
R969 T1839 T1835 punct ],reviewed
R970 T1840 T1835 punct ),reviewed
R971 T1749 T1731 punct (,protein
R972 T1841 T1815 punct .,provides
R973 T1750 T1751 det a,member
R977 T1751 T1731 appos member,protein
R980 T1752 T1751 prep of,member
R984 T1753 T1754 det the,family
R988 T1754 T1752 pobj family,of
R992 T1755 T1754 compound zyxin,family
R995 T1756 T1754 prep of,family