craft-sa-dev Home  

PMC:539061 / 39641-40523 JSONTXT 4 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T8080 0-6 IN denotes Within
T8082 7-10 CD denotes 0.5
T8083 11-12 NN denotes h
T8084 13-15 IN denotes of
T8085 16-19 NN denotes TGF
T8087 19-20 HYPH denotes -
T8086 20-22 NN denotes β2
T8088 23-32 NN denotes treatment
T8089 32-34 , denotes ,
T8090 34-39 NN denotes Snail
T8091 40-48 NN denotes promoter
T8092 49-57 NN denotes activity
T8093 58-61 VBD denotes had
T8081 62-71 VBN denotes increased
T8094 72-78 RB denotes 3-fold
T8095 78-80 , denotes ,
T8096 80-83 CC denotes and
T8097 84-86 IN denotes by
T8099 87-88 CD denotes 2
T8100 89-90 NN denotes h
T8101 90-92 , denotes ,
T8102 92-94 PRP denotes it
T8098 95-101 VBD denotes peaked
T8103 102-104 IN denotes to
T8104 105-118 RB denotes approximately
T8105 119-126 RB denotes 10-fold
T8106 127-131 IN denotes over
T8107 132-139 NN denotes control
T8108 140-146 NNS denotes levels
T8109 147-148 -LRB- denotes (
T8111 148-154 NN denotes Figure
T8110 155-157 NN denotes 5D
T8112 157-158 -RRB- denotes )
T8113 158-159 . denotes .
T8114 159-268 sentence denotes Thereafter, Snail promoter activity rapidly returned to the basal levels seen in unstimulated keratinocytes.
T8115 160-170 RB denotes Thereafter
T8117 170-172 , denotes ,
T8118 172-177 NN denotes Snail
T8119 178-186 NN denotes promoter
T8120 187-195 NN denotes activity
T8121 196-203 RB denotes rapidly
T8116 204-212 VBD denotes returned
T8122 213-215 IN denotes to
T8123 216-219 DT denotes the
T8125 220-225 JJ denotes basal
T8124 226-232 NNS denotes levels
T8126 233-237 VBN denotes seen
T8127 238-240 IN denotes in
T8128 241-253 JJ denotes unstimulated
T8129 254-267 NNS denotes keratinocytes
T8130 267-268 . denotes .
T8131 268-371 sentence denotes The kinetics of Snail promoter activity closely paralleled those observed for Snail protein induction.
T8132 269-272 DT denotes The
T8133 273-281 NNS denotes kinetics
T8135 282-284 IN denotes of
T8136 285-290 NN denotes Snail
T8137 291-299 NN denotes promoter
T8138 300-308 NN denotes activity
T8139 309-316 RB denotes closely
T8134 317-327 VBD denotes paralleled
T8140 328-333 DT denotes those
T8141 334-342 VBN denotes observed
T8142 343-346 IN denotes for
T8143 347-352 NN denotes Snail
T8144 353-360 NN denotes protein
T8145 361-370 NN denotes induction
T8146 370-371 . denotes .
T8147 371-643 sentence denotes Moreover, the stimulatory effects appeared to be specific to TGF-β2, since they were abrogated either by heat inactivation of the TGF-β2 protein or by mutation of a putative SMAD binding element located about 1.8 kb 5′ from the Snail transcription start site (Figure 5D).
T8148 372-380 RB denotes Moreover
T8150 380-382 , denotes ,
T8151 382-385 DT denotes the
T8153 386-397 JJ denotes stimulatory
T8152 398-405 NNS denotes effects
T8149 406-414 VBD denotes appeared
T8154 415-417 TO denotes to
T8155 418-420 VB denotes be
T8156 421-429 JJ denotes specific
T8157 430-432 IN denotes to
T8158 433-436 NN denotes TGF
T8160 436-437 HYPH denotes -
T8159 437-439 NN denotes β2
T8161 439-441 , denotes ,
T8162 441-446 IN denotes since
T8164 447-451 PRP denotes they
T8165 452-456 VBD denotes were
T8163 457-466 VBN denotes abrogated
T8166 467-473 CC denotes either
T8167 474-476 IN denotes by
T8168 477-481 NN denotes heat
T8169 482-494 NN denotes inactivation
T8170 495-497 IN denotes of
T8171 498-501 DT denotes the
T8173 502-505 NN denotes TGF
T8175 505-506 HYPH denotes -
T8174 506-508 NN denotes β2
T8172 509-516 NN denotes protein
T8176 517-519 CC denotes or
T8177 520-522 IN denotes by
T8178 523-531 NN denotes mutation
T8179 532-534 IN denotes of
T8180 535-536 DT denotes a
T8182 537-545 JJ denotes putative
T8183 546-550 NN denotes SMAD
T8184 551-558 NN denotes binding
T8181 559-566 NN denotes element
T8185 567-574 VBN denotes located
T8186 575-580 IN denotes about
T8187 581-584 CD denotes 1.8
T8188 585-587 NN denotes kb
T8189 588-589 CD denotes 5
T8190 589-590 SYM denotes ′
T8191 591-595 IN denotes from
T8192 596-599 DT denotes the
T8194 600-605 NN denotes Snail
T8195 606-619 NN denotes transcription
T8196 620-625 NN denotes start
T8193 626-630 NN denotes site
T8197 631-632 -LRB- denotes (
T8199 632-638 NN denotes Figure
T8198 639-641 NN denotes 5D
T8200 641-642 -RRB- denotes )
T8201 642-643 . denotes .
T8202 643-882 sentence denotes Taken together, these results suggested that in keratinocytes, TGF-β2 signaling results in a pSMAD2-dependent transient activation of the Snail gene, and that maintenance of Snail protein relies, in part, upon sustained promoter activity.
T8203 644-649 VBN denotes Taken
T8205 650-658 RB denotes together
T8206 658-660 , denotes ,
T8207 660-665 DT denotes these
T8208 666-673 NNS denotes results
T8204 674-683 VBD denotes suggested
T8209 684-688 IN denotes that
T8211 689-691 IN denotes in
T8212 692-705 NNS denotes keratinocytes
T8213 705-707 , denotes ,
T8214 707-710 NN denotes TGF
T8216 710-711 HYPH denotes -
T8215 711-713 NN denotes β2
T8217 714-723 NN denotes signaling
T8210 724-731 VBZ denotes results
T8218 732-734 IN denotes in
T8219 735-736 DT denotes a
T8221 737-743 NN denotes pSMAD2
T8223 743-744 HYPH denotes -
T8222 744-753 JJ denotes dependent
T8224 754-763 JJ denotes transient
T8220 764-774 NN denotes activation
T8225 775-777 IN denotes of
T8226 778-781 DT denotes the
T8228 782-787 NN denotes Snail
T8227 788-792 NN denotes gene
T8229 792-794 , denotes ,
T8230 794-797 CC denotes and
T8231 798-802 IN denotes that
T8233 803-814 NN denotes maintenance
T8234 815-817 IN denotes of
T8235 818-823 NN denotes Snail
T8236 824-831 NN denotes protein
T8232 832-838 VBZ denotes relies
T8237 838-840 , denotes ,
T8238 840-842 IN denotes in
T8239 843-847 NN denotes part
T8240 847-849 , denotes ,
T8241 849-853 IN denotes upon
T8242 854-863 JJ denotes sustained
T8244 864-872 NN denotes promoter
T8243 873-881 NN denotes activity
T8245 881-882 . denotes .
R4854 T8080 T8081 prep Within,increased
R4855 T8082 T8083 nummod 0.5,h
R4856 T8083 T8080 pobj h,Within
R4857 T8084 T8083 prep of,h
R4858 T8085 T8086 compound TGF,β2
R4859 T8086 T8088 compound β2,treatment
R4860 T8087 T8086 punct -,β2
R4861 T8088 T8084 pobj treatment,of
R4862 T8089 T8081 punct ", ",increased
R4863 T8090 T8091 compound Snail,promoter
R4864 T8091 T8092 compound promoter,activity
R4865 T8092 T8081 nsubj activity,increased
R4866 T8093 T8081 aux had,increased
R4867 T8094 T8081 advmod 3-fold,increased
R4868 T8095 T8081 punct ", ",increased
R4869 T8096 T8081 cc and,increased
R4870 T8097 T8098 prep by,peaked
R4871 T8098 T8081 conj peaked,increased
R4872 T8099 T8100 nummod 2,h
R4873 T8100 T8097 pobj h,by
R4874 T8101 T8098 punct ", ",peaked
R4875 T8102 T8098 nsubj it,peaked
R4876 T8103 T8098 prep to,peaked
R4877 T8104 T8105 advmod approximately,10-fold
R4878 T8105 T8103 pcomp 10-fold,to
R4879 T8106 T8105 prep over,10-fold
R4880 T8107 T8108 compound control,levels
R4881 T8108 T8106 pobj levels,over
R4882 T8109 T8110 punct (,5D
R4883 T8110 T8098 parataxis 5D,peaked
R4884 T8111 T8110 compound Figure,5D
R4885 T8112 T8110 punct ),5D
R4886 T8113 T8098 punct .,peaked
R4887 T8115 T8116 advmod Thereafter,returned
R4888 T8117 T8116 punct ", ",returned
R4889 T8118 T8119 compound Snail,promoter
R4890 T8119 T8120 compound promoter,activity
R4891 T8120 T8116 nsubj activity,returned
R4892 T8121 T8116 advmod rapidly,returned
R4893 T8122 T8116 prep to,returned
R4894 T8123 T8124 det the,levels
R4895 T8124 T8122 pobj levels,to
R4896 T8125 T8124 amod basal,levels
R4897 T8126 T8124 acl seen,levels
R4898 T8127 T8126 prep in,seen
R4899 T8128 T8129 amod unstimulated,keratinocytes
R4900 T8129 T8127 pobj keratinocytes,in
R4901 T8130 T8116 punct .,returned
R4902 T8132 T8133 det The,kinetics
R4903 T8133 T8134 nsubj kinetics,paralleled
R4904 T8135 T8133 prep of,kinetics
R4905 T8136 T8137 compound Snail,promoter
R4906 T8137 T8138 compound promoter,activity
R4907 T8138 T8135 pobj activity,of
R4908 T8139 T8134 advmod closely,paralleled
R4909 T8140 T8134 dobj those,paralleled
R4910 T8141 T8140 acl observed,those
R4911 T8142 T8141 prep for,observed
R4912 T8143 T8144 compound Snail,protein
R4913 T8144 T8145 compound protein,induction
R4914 T8145 T8142 pobj induction,for
R4915 T8146 T8134 punct .,paralleled
R4916 T8148 T8149 advmod Moreover,appeared
R4917 T8150 T8149 punct ", ",appeared
R4918 T8151 T8152 det the,effects
R4919 T8152 T8149 nsubj effects,appeared
R4920 T8153 T8152 amod stimulatory,effects
R4921 T8154 T8155 aux to,be
R4922 T8155 T8149 xcomp be,appeared
R4923 T8156 T8155 acomp specific,be
R4924 T8157 T8156 prep to,specific
R4925 T8158 T8159 compound TGF,β2
R4926 T8159 T8157 pobj β2,to
R4927 T8160 T8159 punct -,β2
R4928 T8161 T8155 punct ", ",be
R4929 T8162 T8163 mark since,abrogated
R4930 T8163 T8155 advcl abrogated,be
R4931 T8164 T8163 nsubjpass they,abrogated
R4932 T8165 T8163 auxpass were,abrogated
R4933 T8166 T8167 preconj either,by
R4934 T8167 T8163 prep by,abrogated
R4935 T8168 T8169 compound heat,inactivation
R4936 T8169 T8167 pobj inactivation,by
R4937 T8170 T8169 prep of,inactivation
R4938 T8171 T8172 det the,protein
R4939 T8172 T8170 pobj protein,of
R4940 T8173 T8174 compound TGF,β2
R4941 T8174 T8172 compound β2,protein
R4942 T8175 T8174 punct -,β2
R4943 T8176 T8167 cc or,by
R4944 T8177 T8167 conj by,by
R4945 T8178 T8177 pobj mutation,by
R4946 T8179 T8178 prep of,mutation
R4947 T8180 T8181 det a,element
R4948 T8181 T8179 pobj element,of
R4949 T8182 T8181 amod putative,element
R4950 T8183 T8184 compound SMAD,binding
R4951 T8184 T8181 compound binding,element
R4952 T8185 T8181 acl located,element
R4953 T8186 T8187 quantmod about,1.8
R4954 T8187 T8188 nummod 1.8,kb
R4955 T8188 T8185 npadvmod kb,located
R4956 T8189 T8188 nummod 5,kb
R4957 T8190 T8188 punct ′,kb
R4958 T8191 T8188 prep from,kb
R4959 T8192 T8193 det the,site
R4960 T8193 T8191 pobj site,from
R4961 T8194 T8193 compound Snail,site
R4962 T8195 T8193 compound transcription,site
R4963 T8196 T8193 compound start,site
R4964 T8197 T8198 punct (,5D
R4965 T8198 T8163 parataxis 5D,abrogated
R4966 T8199 T8198 compound Figure,5D
R4967 T8200 T8198 punct ),5D
R4968 T8201 T8149 punct .,appeared
R4969 T8203 T8204 advcl Taken,suggested
R4970 T8205 T8203 advmod together,Taken
R4971 T8206 T8204 punct ", ",suggested
R4972 T8207 T8208 det these,results
R4973 T8208 T8204 nsubj results,suggested
R4974 T8209 T8210 mark that,results
R4975 T8210 T8204 advcl results,suggested
R4976 T8211 T8210 prep in,results
R4977 T8212 T8211 pobj keratinocytes,in
R4978 T8213 T8210 punct ", ",results
R4979 T8214 T8215 compound TGF,β2
R4980 T8215 T8217 compound β2,signaling
R4981 T8216 T8215 punct -,β2
R4982 T8217 T8210 nsubj signaling,results
R4983 T8218 T8210 prep in,results
R4984 T8219 T8220 det a,activation
R4985 T8220 T8218 pobj activation,in
R4986 T8221 T8222 npadvmod pSMAD2,dependent
R4987 T8222 T8220 amod dependent,activation
R4988 T8223 T8222 punct -,dependent
R4989 T8224 T8220 amod transient,activation
R4990 T8225 T8220 prep of,activation
R4991 T8226 T8227 det the,gene
R4992 T8227 T8225 pobj gene,of
R4993 T8228 T8227 compound Snail,gene
R4994 T8229 T8210 punct ", ",results
R4995 T8230 T8210 cc and,results
R4996 T8231 T8232 mark that,relies
R4997 T8232 T8210 conj relies,results
R4998 T8233 T8232 nsubj maintenance,relies
R4999 T8234 T8233 prep of,maintenance
R5000 T8235 T8236 compound Snail,protein
R5001 T8236 T8234 pobj protein,of
R5002 T8237 T8232 punct ", ",relies
R5003 T8238 T8232 prep in,relies
R5004 T8239 T8238 pobj part,in
R5005 T8240 T8232 punct ", ",relies
R5006 T8241 T8232 prep upon,relies
R5007 T8242 T8243 amod sustained,activity
R5008 T8243 T8241 pobj activity,upon
R5009 T8244 T8243 compound promoter,activity
R5010 T8245 T8204 punct .,suggested